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Aliases for SLC2A10 Gene

Aliases for SLC2A10 Gene

  • Solute Carrier Family 2 Member 10 2 3 5
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 10 2 3
  • Glucose Transporter Type 10 3 4
  • GLUT-10 3 4
  • GLUT10 3 4
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 10 3
  • ATS 3

External Ids for SLC2A10 Gene

Previous GeneCards Identifiers for SLC2A10 Gene

  • GC20P045066
  • GC20P045976
  • GC20P046023
  • GC20P044771
  • GC20P045338
  • GC20P042079

Summaries for SLC2A10 Gene

Entrez Gene Summary for SLC2A10 Gene

  • This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity syndrome.[provided by RefSeq, Dec 2009]

GeneCards Summary for SLC2A10 Gene

SLC2A10 (Solute Carrier Family 2 Member 10) is a Protein Coding gene. Diseases associated with SLC2A10 include Arterial Tortuosity Syndrome and Thoracic Aortic Aneurysms And Aortic Dissections. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and PAK Pathway. GO annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A12.

UniProtKB/Swiss-Prot for SLC2A10 Gene

  • Facilitative glucose transporter.

Gene Wiki entry for SLC2A10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A10 Gene

Genomics for SLC2A10 Gene

Regulatory Elements for SLC2A10 Gene

Enhancers for SLC2A10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G046708 1.1 ENCODE 13.4 +1.2 1170 2.7 FOXA2 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 SLC2A10 ENSG00000271784 GC20P046790
GH20G046606 1 ENCODE 14.3 -100.8 -100808 1.4 FOXA2 MLX ARID4B DMAP1 ZNF48 SLC30A9 SP5 ZHX2 MXD4 MIER2 SLC2A10 SLC13A3 OCSTAMP ENSG00000273893
GH20G046787 1.1 dbSUPER 10.9 +79.7 79677 1.8 FOXA2 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 NCOA5 TP53RK CD40 LOC100419565 PCIF1 SLC2A10 GC20P046790
GH20G046683 1 ENCODE 11.1 -24.4 -24378 2.3 ATF1 FOXA2 CREB3L1 ARNT ZNF2 YY1 TCF12 ZNF121 ZNF143 ZNF263 TP53RK ZNF335 SLC2A10 OCSTAMP SLC13A3 ENSG00000273893
GH20G046681 1 ENCODE 11.1 -27.0 -27031 0.2 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B YBX1 ZNF2 TCF12 SLC30A9 SLC2A10 ENSG00000273893 OCSTAMP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC2A10 on UCSC Golden Path with GeneCards custom track

Promoters for SLC2A10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000137829 1553 1001 FOXA2 CREB3L1 MLX ARID4B DMAP1 ZNF48 SLC30A9 GLIS2 ZNF207 SP5

Genomic Location for SLC2A10 Gene

46,708,347 bp from pter
46,736,347 bp from pter
28,001 bases
Plus strand

Genomic View for SLC2A10 Gene

Genes around SLC2A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A10 Gene

Proteins for SLC2A10 Gene

  • Protein details for SLC2A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 10
    Protein Accession:
    Secondary Accessions:
    • A8K4J6
    • Q3MIX5
    • Q9H4I6

    Protein attributes for SLC2A10 Gene

    541 amino acids
    Molecular mass:
    56911 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC2A10 Gene

Post-translational modifications for SLC2A10 Gene

  • Ubiquitination at isoforms=208
  • Glycosylation at isoforms=334
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC2A10 Gene

Domains & Families for SLC2A10 Gene

Gene Families for SLC2A10 Gene

Suggested Antigen Peptide Sequences for SLC2A10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A10: view

Function for SLC2A10 Gene

Molecular function for SLC2A10 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.28 mM for 2-deoxy-D-glucose;
UniProtKB/Swiss-Prot Function:
Facilitative glucose transporter.

Gene Ontology (GO) - Molecular Function for SLC2A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 sugar:proton symporter activity NAS 11247674
GO:0005355 glucose transmembrane transporter activity IBA --
GO:0022857 transmembrane transporter activity IEA --
GO:0022891 substrate-specific transmembrane transporter activity IEA --
GO:0055056 D-glucose transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLC2A10: view
genes like me logo Genes that share phenotypes with SLC2A10: view

Human Phenotype Ontology for SLC2A10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC2A10

CRISPR Products

miRNA for SLC2A10 Gene

miRTarBase miRNAs that target SLC2A10

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC2A10 Gene

Localization for SLC2A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A10 Gene

Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC2A10 gene
Compartment Confidence
plasma membrane 5
cytosol 5
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC2A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane TAS --
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC2A10: view

Pathways & Interactions for SLC2A10 Gene

genes like me logo Genes that share pathways with SLC2A10: view

Gene Ontology (GO) - Biological Process for SLC2A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008643 carbohydrate transport IEA --
GO:0015758 glucose transport NAS 11247674
GO:0015992 proton transport IEA --
GO:0035428 hexose transmembrane transport IBA --
genes like me logo Genes that share ontologies with SLC2A10: view

No data available for SIGNOR curated interactions for SLC2A10 Gene

Drugs & Compounds for SLC2A10 Gene

(2) Drugs for SLC2A10 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fludeoxyglucose F-18 Approved Pharma Transporter, substrate 0
genes like me logo Genes that share compounds with SLC2A10: view

Transcripts for SLC2A10 Gene

Unigene Clusters for SLC2A10 Gene

Solute carrier family 2 (facilitated glucose transporter), member 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A10 Gene

No ASD Table

Relevant External Links for SLC2A10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC2A10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC2A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC2A10 Gene

This gene is overexpressed in Liver (x7.7).

Protein differential expression in normal tissues from HIPED for SLC2A10 Gene

This gene is overexpressed in Liver (51.9), Placenta (8.0), and Breast (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC2A10 Gene

Protein tissue co-expression partners for SLC2A10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC2A10 Gene:


SOURCE GeneReport for Unigene cluster for SLC2A10 Gene:


mRNA Expression by UniProt/SwissProt for SLC2A10 Gene:

Tissue specificity: Widely expressed; highest levels in liver and pancreas.

Evidence on tissue expression from TISSUES for SLC2A10 Gene

  • Liver(4.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC2A10 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • cheek
  • chin
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • outer ear
  • skull
  • aorta
  • chest wall
  • diaphragm
  • esophagus
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • sternum
  • abdominal wall
  • intestine
  • large intestine
  • liver
  • small intestine
  • stomach
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
  • blood
  • blood vessel
  • coagulation system
  • skin
genes like me logo Genes that share expression patterns with SLC2A10: view

Primer Products

Orthologs for SLC2A10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC2A10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC2A10 34 35
  • 98.58 (n)
(Canis familiaris)
Mammalia SLC2A10 34 35
  • 85.78 (n)
(Bos Taurus)
Mammalia SLC2A10 34 35
  • 84.51 (n)
(Rattus norvegicus)
Mammalia Slc2a10 34
  • 78.48 (n)
(Mus musculus)
Mammalia Slc2a10 34 16 35
  • 78.23 (n)
(Monodelphis domestica)
Mammalia SLC2A10 35
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia SLC2A10 35
  • 59 (a)
(Gallus gallus)
Aves SLC2A10 34 35
  • 64.56 (n)
(Anolis carolinensis)
Reptilia SLC2A10 35
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc2a10 34
  • 58.86 (n)
Str.16625 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.3328 34
(Danio rerio)
Actinopterygii slc2a10 34 35
  • 53.37 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 21 (a)
ITR1 35
  • 20 (a)
ITR2 35
  • 19 (a)
Species where no ortholog for SLC2A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC2A10 Gene

Gene Tree for SLC2A10 (if available)
Gene Tree for SLC2A10 (if available)

Paralogs for SLC2A10 Gene

Paralogs for SLC2A10 Gene

(9) SIMAP similar genes for SLC2A10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC2A10: view

Variants for SLC2A10 Gene

Sequence variations from dbSNP and Humsavar for SLC2A10 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs121908172 Pathogenic, Arterial tortuosity syndrome (ATS) [MIM:208050] 46,726,312(+) CCTTT(G/T)GGTTT nc-transcript-variant, reference, missense
rs121908173 Pathogenic, Arterial tortuosity syndrome (ATS) [MIM:208050] 46,725,430(+) GGCAG(C/T)GGGGA nc-transcript-variant, reference, missense
rs564317065 Pathogenic, Arterial tortuosity syndrome (ATS) [MIM:208050] 46,725,773(+) AACAG(A/G)GCAGC nc-transcript-variant, reference, missense
rs753723351 Pathogenic, Arterial tortuosity syndrome (ATS) [MIM:208050] 46,726,909(+) ACGAG(A/G)AAGAG nc-transcript-variant, reference, synonymous-codon, missense
rs763220502 Pathogenic, Arterial tortuosity syndrome (ATS) [MIM:208050] 46,726,884(+) TCAGC(A/G)AGATC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SLC2A10 Gene

Variant ID Type Subtype PubMed ID
nsv1061899 CNV loss 25217958
nsv1136547 CNV deletion 24896259

Variation tolerance for SLC2A10 Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.16; 75.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC2A10 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A10 Gene

Disorders for SLC2A10 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLC2A10 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
arterial tortuosity syndrome
  • arterial tortuosity
thoracic aortic aneurysms and aortic dissections
  • taad
gingival recession
  • gingival recession nos
- elite association - COSMIC cancer census association via MalaCards


  • Arterial tortuosity syndrome (ATS) [MIM:208050]: An autosomal recessive disorder characterized by tortuosity and elongation of major arteries, often resulting in death at young age. Other typical features include aneurysms of large arteries and stenosis of the pulmonary artery, in association with facial features and several connective tissue manifestations such as soft skin and joint laxity. Histopathological findings include fragmentation of elastic fibers in the tunica media of large arteries. {ECO:0000269 PubMed:16550171, ECO:0000269 PubMed:17935213}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SLC2A10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLC2A10: view

No data available for Genatlas for SLC2A10 Gene

Publications for SLC2A10 Gene

  1. Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits. (PMID: 12941788) Andersen G. … Pedersen O. (Diabetes 2003) 3 4 22 46 64
  2. Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in the Taiwanese population. (PMID: 16586067) Lin W.H. … Chen Y.T. (Diabetologia 2006) 3 22 46 64
  3. Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome. (PMID: 16550171) Coucke P.J. … De Paepe A. (Nat. Genet. 2006) 3 4 22 64
  4. Genetic analysis of the GLUT10 glucose transporter (SLC2A10) polymorphisms in Caucasian American type 2 diabetes. (PMID: 16336637) Bento J.L. … Segade F. (BMC Med. Genet. 2005) 3 22 46 64
  5. Evaluation of SLC2A10 (GLUT10) as a candidate gene for type 2 diabetes and related traits in Finns. (PMID: 15936967) Mohlke K.L. … Collins F.S. (Mol. Genet. Metab. 2005) 3 22 46 64

Products for SLC2A10 Gene

Sources for SLC2A10 Gene

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