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Aliases for SLC2A10 Gene

Aliases for SLC2A10 Gene

  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 10 2 3
  • GLUT10 3 4 6
  • Glucose Transporter Type 10 3 4
  • GLUT-10 3 4
  • ATS 3 6
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 10 3

External Ids for SLC2A10 Gene

Previous GeneCards Identifiers for SLC2A10 Gene

  • GC20P045066
  • GC20P045976
  • GC20P046023
  • GC20P044771
  • GC20P045338
  • GC20P042079

Summaries for SLC2A10 Gene

Entrez Gene Summary for SLC2A10 Gene

  • This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity syndrome.[provided by RefSeq, Dec 2009]

GeneCards Summary for SLC2A10 Gene

SLC2A10 (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 10) is a Protein Coding gene. Diseases associated with SLC2A10 include arterial tortuosity syndrome and loeys-dietz syndrome. Among its related pathways are PAK Pathway and HIF1Alpha Pathway. GO annotations related to this gene include sugar:proton symporter activity. An important paralog of this gene is SLC2A13.

UniProtKB/Swiss-Prot for SLC2A10 Gene

  • Facilitative glucose transporter

Gene Wiki entry for SLC2A10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A10 Gene

Genomics for SLC2A10 Gene

Regulatory Elements for SLC2A10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC2A10 Gene

46,709,487 bp from pter
46,736,347 bp from pter
26,861 bases
Plus strand

Genomic View for SLC2A10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC2A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A10 Gene

Proteins for SLC2A10 Gene

  • Protein details for SLC2A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 10
    Protein Accession:
    Secondary Accessions:
    • A8K4J6
    • Q3MIX5
    • Q9H4I6

    Protein attributes for SLC2A10 Gene

    541 amino acids
    Molecular mass:
    56911 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC2A10 Gene

Proteomics data for SLC2A10 Gene at MOPED

Post-translational modifications for SLC2A10 Gene

Other Protein References for SLC2A10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC2A10 Gene

Domains for SLC2A10 Gene

Gene Families for SLC2A10 Gene

Suggested Antigen Peptide Sequences for SLC2A10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A10: view

Function for SLC2A10 Gene

Molecular function for SLC2A10 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.28 mM for 2-deoxy-D-glucose;
UniProtKB/Swiss-Prot Function:
Facilitative glucose transporter

Gene Ontology (GO) - Molecular Function for SLC2A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 sugar:proton symporter activity NAS 11247674
GO:0005355 glucose transmembrane transporter activity IBA --
GO:0022857 transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC2A10: view
genes like me logo Genes that share phenotypes with SLC2A10: view

Animal Model Products

CRISPR Products

miRNA for SLC2A10 Gene

miRTarBase miRNAs that target SLC2A10

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC2A10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC2A10 Gene

Localization for SLC2A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A10 Gene

Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region.

Subcellular locations from

Jensen Localization Image for SLC2A10 Gene COMPARTMENTS Subcellular localization image for SLC2A10 gene
Compartment Confidence
plasma membrane 4
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC2A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0012505 endomembrane system IEA --
GO:0016021 integral component of membrane NAS 11247674
genes like me logo Genes that share ontologies with SLC2A10: view

Pathways for SLC2A10 Gene

genes like me logo Genes that share pathways with SLC2A10: view

Interacting Proteins for SLC2A10 Gene

Gene Ontology (GO) - Biological Process for SLC2A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015758 glucose transport NAS 11247674
GO:0015992 proton transport NAS 11247674
GO:0035428 hexose transmembrane transport IBA --
GO:0046323 glucose import IBA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC2A10: view

Drugs for SLC2A10 Gene

(1) Novoseek inferred chemical compound relationships for SLC2A10 Gene

Compound -log(P) Hits PubMed IDs
glucose 49 11
genes like me logo Genes that share compounds with SLC2A10: view

Transcripts for SLC2A10 Gene

Unigene Clusters for SLC2A10 Gene

Solute carrier family 2 (facilitated glucose transporter), member 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC2A10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A10 Gene

No ASD Table

Relevant External Links for SLC2A10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC2A10 Gene

mRNA expression in normal human tissues for SLC2A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC2A10 Gene

This gene is overexpressed in Liver (7.7).

Protein differential expression in normal tissues for SLC2A10 Gene

This gene is overexpressed in Liver (51.9), Placenta (8.0), and Breast (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC2A10 Gene

SOURCE GeneReport for Unigene cluster for SLC2A10 Gene Hs.305971

mRNA Expression by UniProt/SwissProt for SLC2A10 Gene

Tissue specificity: Widely expressed; highest levels in liver and pancreas.
genes like me logo Genes that share expressions with SLC2A10: view

Expression partners for SLC2A10 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for SLC2A10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC2A10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC2A10 35
  • 84.51 (n)
  • 82.65 (a)
SLC2A10 36
  • 82 (a)
(Canis familiaris)
Mammalia SLC2A10 35
  • 85.78 (n)
  • 84.23 (a)
SLC2A10 36
  • 83 (a)
(Mus musculus)
Mammalia Slc2a10 35
  • 78.23 (n)
  • 78.17 (a)
Slc2a10 16
Slc2a10 36
  • 77 (a)
(Pan troglodytes)
Mammalia SLC2A10 35
  • 98.58 (n)
  • 98.89 (a)
SLC2A10 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slc2a10 35
  • 78.48 (n)
  • 78.54 (a)
(Monodelphis domestica)
Mammalia SLC2A10 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia SLC2A10 36
  • 59 (a)
(Gallus gallus)
Aves SLC2A10 35
  • 64.56 (n)
  • 60.99 (a)
SLC2A10 36
  • 55 (a)
(Anolis carolinensis)
Reptilia SLC2A10 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc2a10 35
  • 58.86 (n)
  • 57.12 (a)
Str.16625 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3328 35
(Danio rerio)
Actinopterygii slc2a10 35
  • 53.37 (n)
  • 47.98 (a)
slc2a10 36
  • 45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 21 (a)
ITR1 36
  • 20 (a)
ITR2 36
  • 19 (a)
Species with no ortholog for SLC2A10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC2A10 Gene

Gene Tree for SLC2A10 (if available)
Gene Tree for SLC2A10 (if available)

Paralogs for SLC2A10 Gene

Paralogs for SLC2A10 Gene

(9) SIMAP similar genes for SLC2A10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC2A10: view

Variants for SLC2A10 Gene

Sequence variations from dbSNP and Humsavar for SLC2A10 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs145974990 -- 46,735,956(+) ATGCC(A/G)AACCT utr-variant-3-prime, downstream-variant-500B
rs145994112 -- 46,725,884(+) GGCAG(A/C)TACCC missense, reference, nc-transcript-variant
rs145764132 -- 46,730,012(+) TTTGA(C/T)TTTAA intron-variant
rs145683930 -- 46,726,233(+) CCCCC(A/T)CTGCC synonymous-codon, reference, nc-transcript-variant
rs145659556 -- 46,727,241(+) AGCAA(C/T)GTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC2A10 Gene

Variant ID Type Subtype PubMed ID
nsv912901 CNV Loss 21882294

Relevant External Links for SLC2A10 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A10 Gene

Disorders for SLC2A10 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SLC2A10 Gene in MalaCards »

(2) Diseases for SLC2A10 Gene

(1) OMIM Diseases for SLC2A10 Gene (606145)


  • Arterial tortuosity syndrome (ATS) [MIM:208050]: An autosomal recessive disorder characterized by tortuosity and elongation of major arteries, often resulting in death at young age. Other typical features include aneurysms of large arteries and stenosis of the pulmonary artery, in association with facial features and several connective tissue manifestations such as soft skin and joint laxity. Histopathological findings include fragmentation of elastic fibers in the tunica media of large arteries. {ECO:0000269 PubMed:16550171, ECO:0000269 PubMed:17935213}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for SLC2A10 Gene

Relevant External Links for SLC2A10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLC2A10: view

No data available for Novoseek inferred disease relationships and Genatlas for SLC2A10 Gene

Publications for SLC2A10 Gene

  1. Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits. (PMID: 12941788) Andersen G. … Pedersen O. (Diabetes 2003) 3 4 23 48
  2. Evaluation of SLC2A10 (GLUT10) as a candidate gene for type 2 diabetes and related traits in Finns. (PMID: 15936967) Mohlke K.L. … Collins F.S. (Mol. Genet. Metab. 2005) 3 23 48
  3. Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome. (PMID: 16550171) Coucke P.J. … De Paepe A. (Nat. Genet. 2006) 3 4 23
  4. Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in the Taiwanese population. (PMID: 16586067) Lin W.H. … Chen Y.T. (Diabetologia 2006) 3 23 48
  5. Molecular cloning of a novel member of the GLUT family of transporters, SLC2A10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility. (PMID: 11247674) McVie-Wylie A.J. … Chen Y.T. (Genomics 2001) 2 3 4

Products for SLC2A10 Gene

Sources for SLC2A10 Gene

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