Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SLC2A10 Gene

protein-coding   GIFtS: 58
GCID: GC20P045338

Solute Carrier Family 2 (Facilitated Glucose Transporter),...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Solute Carrier Family 2 (Facilitated Glucose Transporter), Member
101 2
GLUT102 3 5
Glucose Transporter Type 102 3
GLUT-102 3
ATS2 5
Solute Carrier Family 2, Facilitated Glucose Transporter Member 102

External Ids:    HGNC: 134441   Entrez Gene: 810312   Ensembl: ENSG000001974967   OMIM: 6061455   UniProtKB: O955283   

Export aliases for SLC2A10 gene to outside databases

Previous GC identifers: GC20P045066 GC20P045976 GC20P046023 GC20P044771 GC20P042079


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SLC2A10 Gene:
This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a
role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity
syndrome.(provided by RefSeq, Dec 2009)

GeneCards Summary for SLC2A10 Gene:
SLC2A10 (solute carrier family 2 (facilitated glucose transporter), member 10) is a protein-coding gene. Diseases associated with SLC2A10 include arterial tortuosity syndrome, and loeys-dietz syndrome. GO annotations related to this gene include sugar:hydrogen symporter activity. An important paralog of this gene is SLC2A13.

UniProtKB/Swiss-Prot: GTR10_HUMAN, O95528
Function: Facilitative glucose transporter

Gene Wiki entry for SLC2A10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000020.11  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC2A10 gene promoter:
         RFX1   NCX/Ncx   FOXD3   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   POU2F1   POU2F1a   HSF2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC2A10 promoter sequence
   Search Chromatin IP Primers for SLC2A10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC2A10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.1   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

SLC2A10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC2A10 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P045338:  view genomic region     (about GC identifiers)

Start:
45,338,126 bp from pter      End:
45,364,986 bp from pter
Size:
26,861 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GTR10_HUMAN, O95528 (See protein sequence)
Recommended Name: Solute carrier family 2, facilitated glucose transporter member 10  
Size: 541 amino acids; 56911 Da
Secondary accessions: A8K4J6 Q3MIX5 Q9H4I6

Explore the universe of human proteins at neXtProt for SLC2A10: NX_O95528

Explore proteomics data for SLC2A10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys208
  • Glycosylation2 at Asn334
  • Modification sites at PhosphoSitePlus

  • See SLC2A10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_110404.1  
    ENSEMBL proteins: 
     ENSP00000352216  
    Reactome Protein details: O95528

    SLC2A10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SLC2A10
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SLC2A10
    GenScript Custom Purified and Recombinant Proteins Services for SLC2A10
    Novus Biologicals SLC2A10 Proteins
    Novus Biologicals SLC2A10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    SLC2A10 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SLC2A10
    OriGene Custom Antibody Services for SLC2A10
    Novus Biologicals SLC2A10 Antibodies
    Search for Antibodies for SLC2A10 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for SLC2A10
    LSBio Antibodies in human, mouse, rat for SLC2A10

    SLC2A10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC2A10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC2A10
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Glucose transporter 10
    Class II transporters

    5 InterPro protein domains:
     IPR005829 Sugar_transporter_CS
     IPR005828 Sub_transporter
     IPR003663 Sugar/inositol_transpt
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry O95528

    ProtoNet protein and cluster: O95528

    2 Blocks protein domains:
    IPB003663 Sugar transporter signature
    IPB005829 Sugar transporter superfamily


    UniProtKB/Swiss-Prot: GTR10_HUMAN, O95528
    Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose
    transporter subfamily


    SLC2A10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GTR10_HUMAN, O95528
    Function: Facilitative glucose transporter
    Biophysicochemical properties: Kinetic parameters: KM=0.28 mM for 2-deoxy-D-glucose;

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005351sugar:hydrogen symporter activity NAS11247674
    GO:0022857transmembrane transporter activity ----
         
    SLC2A10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC2A10:
     Decreased viability with pacli 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc2a10):
     cardiovascular system  hematopoietic system  immune system  renal/urinary system  respiratory system 

    SLC2A10 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC2A10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC2A10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC2A10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC2A10

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLC2A10:
    hsa-mir-335-5p (MIRT018588)

    Block miRNA regulation of human, mouse, rat SLC2A10 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate SLC2A10:
    hsa-miR-4324 hsa-miR-873 hsa-miR-509-5p hsa-miR-2110 hsa-miR-4330 hsa-miR-3065-5p hsa-miR-1827 hsa-miR-509-3-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLC2A10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC2A10
    Predesigned siRNA for gene silencing in human, mouse, rat SLC2A10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC2A10

    Clone
    Products:
         
    OriGene clones in human, mouse for SLC2A10 (see all 6)
    OriGene ORF clones in mouse, rat for SLC2A10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC2A10 (NM_030777)
    Sino Biological Human cDNA Clone for SLC2A10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC2A10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC2A10

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC2A10
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLC2A10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC2A10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GTR10_HUMAN, O95528: Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane TAS--
    GO:0012505endomembrane system IEA--
    GO:0016021integral component of membrane NAS11247674
    GO:0048471perinuclear region of cytoplasm IEA--

    SLC2A10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SLC2A10 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    Facilitative Na+-independent glucose transporters0.00
    2PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    3HIF1Alpha Pathway
    HIF1Alpha Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SLC2A10
        Antioxidant Action of Vitamin-C
    HIF1Alpha Pathway


    1 Reactome Pathway for SLC2A10
        Facilitative Na+-independent glucose transporters



    SLC2A10 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC2A10
    Interactions:

        Search GeneGlobe Interaction Network for SLC2A10

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SLC2A10 (ENSP000003522164) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GALTENSP000003681194STRING: ENSP00000368119
    GALMENSP000002722524STRING: ENSP00000272252
    DHDHENSP000002214034STRING: ENSP00000221403
    --ENSP000003130264STRING: ENSP00000313026
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015758glucose transport NAS11247674
    GO:0015992proton transport NAS11247674
    GO:0055085transmembrane transport TAS--

    SLC2A10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC2A10 (GTR10)

    1 Novoseek inferred chemical compound relationship for SLC2A10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 49 29 18774132 (1), 16550171 (1), 16586067 (1), 18693279 (1) (see all 11)



    SLC2A10 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SLC2A10 gene: 
    NM_030777.3  

    Unigene Cluster for SLC2A10:

    Solute carrier family 2 (facilitated glucose transporter), member 10
    Hs.305971  [show with all ESTs]
    Unigene Representative Sequence: AF248053
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359271(uc002xsl.3) ENST00000486000
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC2A10 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate SLC2A10:
    hsa-miR-4324 hsa-miR-873 hsa-miR-509-5p hsa-miR-2110 hsa-miR-4330 hsa-miR-3065-5p hsa-miR-1827 hsa-miR-509-3-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLC2A10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLC2A10
    Predesigned siRNA for gene silencing in human, mouse, rat SLC2A10
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC2A10 (see all 6)
    OriGene ORF clones in mouse, rat for SLC2A10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC2A10 (NM_030777)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC2A10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC2A10
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLC2A10
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC2A10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC2A10
      QuantiTect SYBR Green Assays in human, mouse, rat SLC2A10
      QuantiFast Probe-based Assays in human, mouse, rat SLC2A10

    Additional mRNA sequence: 

    AF248053.1 AF321240.1 AF479407.1 AK055548.1 AK290961.1 AK315269.1 AL137188.3 BC101657.1 
    BC113423.1 

    7 DOTS entries:

    DT.412509  DT.95112248  DT.100767685  DT.120823140  DT.86835913  DT.92427962  DT.120823143 

    Selected AceView cDNA sequences (see all 104):

    AF321240 BU739858 AL449903 AU280287 AF479407 BM720038 BU676601 BX100500 
    W31204 CB053561 AI289525 CK820177 NM_030777 AK055548 BQ002484 AI334230 
    AW194341 BQ639648 AL137188 BP351705 AA233364 BG563879 BF477797 AL449909 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SLC2A10 expression in normal human tissues (normalized intensities)      SLC2A10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAAATCGC
    SLC2A10 Expression
    About this image


    SLC2A10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Brain (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Spinal Cord (Nervous System)
    SLC2A10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC2A10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.305971

    UniProtKB/Swiss-Prot: GTR10_HUMAN, O95528
    Tissue specificity: Widely expressed; highest levels in liver and pancreas

        Custom PCR Arrays for SLC2A10
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLC2A10
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC2A10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC2A10
    QuantiTect SYBR Green Assays in human, mouse, rat SLC2A10
    QuantiFast Probe-based Assays in human, mouse, rat SLC2A10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC2A10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC2A10 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc2a101 , 5 solute carrier family 2 (facilitated glucose transporter), more1, 5 78.23(n)1
    78.17(a)1
      2 (85.66 cM)5
    1704411  NM_130451.21  NP_569718.11 
     1655037875 
    chicken
    (Gallus gallus)
    Aves SLC2A101 solute carrier family 2 (facilitated glucose transporter), more 64.56(n)
    60.99(a)
      419206  XM_417383.4  XP_417383.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLC2A106
    solute carrier family 2 (facilitated glucose trans...
    52(a)
    1 ↔ 1
    4(144690958-144710455)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.33282 Xenopus laevis transcribed sequence with weak similarity more 73.84(n)    48047084 
    zebrafish
    (Danio rerio)
    Actinopterygii BM777825.12   -- 73.78(n)    BM777825.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    ITR16
    (see all 3)
    Putative transporter, member of the sugar porter f...
    Myo-inositol transporter with strong similarity to...
    (see all 3)
    21(a)
    20(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    IV(1248154-1249821) YDR387C
    IV(1443713-1445467) YDR497C


    ENSEMBL Gene Tree for SLC2A10 (if available)
    TreeFam Gene Tree for SLC2A10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SLC2A10 gene
    SLC2A132  SLC2A122  
    9 SIMAP similar genes for SLC2A10 using alignment to 2 protein entries:     GTR10_HUMAN (see all proteins):
    SLC2A12    SLC2A7    SLC2A8    SLC2A14    SLC2A13    SLC2A5
    SLC2A1    SLC2A9    SLC2A2

    SLC2A10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SLC2A10 (see all 751)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0424244
    Arterial tortuosity syndrome (ATS)4--see VAR_0424242 G E mis40--------
    VAR_0295354
    Arterial tortuosity syndrome (ATS)4--see VAR_0295352 S R mis40--------
    VAR_0424234
    Arterial tortuosity syndrome (ATS)4--see VAR_0424232 E K mis40--------
    VAR_0424204
    Arterial tortuosity syndrome (ATS)4--see VAR_0424202 R Q mis40--------
    VAR_0424214
    Arterial tortuosity syndrome (ATS)4--see VAR_0424212 G E mis40--------
    VAR_0424184
    Arterial tortuosity syndrome (ATS)4--see VAR_0424182 G V mis40--------
    VAR_0424174
    Arterial tortuosity syndrome (ATS)4--see VAR_0424172 R W mis40--------
    VAR_0424224
    Arterial tortuosity syndrome (ATS)4--see VAR_0424222 G W mis40--------
    rs803582301,2
    Cpathogenic145324789(+) GGGAGC/GAACTT 2 S R mis10--------
    rs803582291,2
    Cpathogenic145325056(+) GGCTGA/GGCCAC 2 * W stg10--------

    HapMap Linkage Disequilibrium report for SLC2A10 (45338126 - 45364986 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SLC2A10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912901CNV Loss21882294

    Human Gene Mutation Database (HGMD): SLC2A10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC2A10
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC2A10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606145   
    OMIM disorders: 208050  
    UniProtKB/Swiss-Prot: GTR10_HUMAN, O95528
  • Arterial tortuosity syndrome (ATS) [MIM:208050]: An autosomal recessive disorder characterized by
    tortuosity and elongation of major arteries, often resulting in death at young age. Other typical features
    include aneurysms of large arteries and stenosis of the pulmonary artery, in association with facial features and
    several connective tissue manifestations such as soft skin and joint laxity. Histopathological findings include
    fragmentation of elastic fibers in the tunica media of large arteries. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 7 diseases for SLC2A10:    About MalaCards
    arterial tortuosity syndrome    loeys-dietz syndrome    aortic aneurysm    tuberculosis
    multiple myeloma    myeloma    endotheliitis

    2 diseases from the University of Copenhagen DISEASES database for SLC2A10:
    Arterial tortuosity syndrome     Loeys-Dietz syndrome

    SLC2A10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC2A10
    Human Genome Epidemiology (HuGE) Navigator: SLC2A10 (10 documents)

    Export disorders for SLC2A10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SLC2A10 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with SLC2A10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits. (PubMed id 12941788)1, 2, 4, 9 Andersen G.... Pedersen O. (Diabetes 2003)
    2. Molecular cloning of a novel member of the GLUT family of transporters, SLC2A10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility. (PubMed id 11247674)1, 2, 3 McVie-Wylie A.J.... Chen Y.T. (Genomics 2001)
    3. Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in the Taiwanese population. (PubMed id 16586067)1, 4, 9 Lin W.H....Chen Y.T. (Diabetologia 2006)
    4. Genetic analysis of the GLUT10 glucose transporter (SLC2A10) polymorphisms in Caucasian American type 2 diabetes. (PubMed id 16336637)1, 4, 9 Bento J.L....Segade F. (BMC Med. Genet. 2005)
    5. Evaluation of SLC2A10 (GLUT10) as a candidate gene for type 2 diabetes and related traits in Finns. (PubMed id 15936967)1, 4, 9 Mohlke K.L....Collins F.S. (Mol. Genet. Metab. 2005)
    6. Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome. (PubMed id 16550171)1, 2, 9 Coucke P.J.... De Paepe A. (Nat. Genet. 2006)
    7. SLC2A10 genetic polymorphism predicts development of peripheral arterial disease in patients with type 2 diabetes. SLC2A10 and PAD in type 2 diabetes. (PubMed id 20735855)1, 4 Jiang Y.D....Chuang L.M. (BMC Med. Genet. 2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Studies of relationships between the GLUT10 Ala206Thr polymorphism and impaired insulin secretion. (PubMed id 15975113)1, 4 Rose C.S....Hansen T. (Diabet. Med. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 81031 HGNC: 13444 AceView: SLC2A10 Ensembl:ENSG00000197496 euGenes: HUgn81031
    ECgene: SLC2A10 H-InvDB: SLC2A10

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SLC2A10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SLC2A10 gene:
    Search GeneIP for patents involving SLC2A10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SLC2A10   OriGene RNAi products in human, mouse, rat for SLC2A10  
     OriGene qPCR primer pairs and template standards for SLC2A10   OriGene Protein Over-expression Lysate for SLC2A10  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC2A10  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC2A10   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC2A10   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC2A10   OriGene Custom Protein Services for SLC2A10  

     
     
     Block miRNA regulation of human, mouse, rat SLC2A10 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLC2A10
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC2A10 Predesigned siRNA for gene silencing in human, mouse, rat SLC2A10
     QuantiFast Probe-based Assays in human, mouse, rat SLC2A10 QuantiTect SYBR Green Assays in human, mouse, rat SLC2A10
     Custom PCR Arrays for SLC2A10 Search Chromatin IP Primers for SLC2A10
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC2A10  Search GeneGlobe Interaction Network for SLC2A10
     Regulatory tfbs in SLC2A10 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SLC2A10 GenScript cDNA clones with any tag delivered in your preferred vector for SLC2A10
     GenScript Custom Assay Services for SLC2A10 GenScript Custom overexpressing Cell Line Services for SLC2A10
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SLC2A10 (GTR10)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for SLC2A10
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SLC2A10 antibodies
     SLC2A10 proteins
     SLC2A10 lysates
     Search for Antibodies for SLC2A10 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SLC2A10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SLC2A10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC2A10
     SwitchGear 3'UTR luciferase reporter plasmids for SLC2A10
     SwitchGear Promoter luciferase reporter plasmids for SLC2A10
     ThermoFisher Antibody for SLC2A10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC2A10
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC2A10
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC2A10
     LSBio Antibodies in human, mouse, rat for SLC2A10
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC2A10 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4