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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC29A4 Gene

protein-coding GIFtS: 55
GCID: GC07P005289

solute carrier family 29 (nucleoside transporters), member...

Explore 4 diseases affiliated with
SLC29A4 via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 29 (Nucleoside Transporters), Member 4¹ ²		PMAT² ³
ENT4¹ ² ³		HENT4¹
Plasma Membrane Monoamine Transporter² ³		FLJ34923¹
Solute Carrier Family 29 Member 4² ³		Equilibrative Nucleoside Transporter 4²

External Ids:	HGNC: 23097¹	Entrez Gene: 222962²	Ensembl: ENSG00000164638⁷	OMIM: 609149⁵	UniProtKB: Q7RTT9³

Export aliases for SLC29A4 gene to outside databases

Previous GC identifers: GC07P005032 GC07P005066 GC07P005095

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC29A4:

This gene is a member of the SLC29 family and encodes a plasma membrane protein with 11 transmembrane helices. This

protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of

monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the

neurotoxin 1-methyl-4-phenylpyridinium. Alternate transcriptional splice variants which encode the same protein have

been characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: S29A4_HUMAN, Q7RTT9

Function: Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as

monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine,

norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine

neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal

proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs

such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718)

adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in

the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for

cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to changes in membrane

potential. Weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep,

and nitrobenzylthioinosine. May play a role in the regulation of extracellular adenosine concentrations in cardiac

tissues, in particular during ischemia

summary for SLC29A4:

Nucleoside transporters are divided into two families; the Na+-dependent solute carrier family 28 (SLC28)

and the equilibrative solute carrier family 29 (SLC29). SLC28 family transporters (CNT1-3) display

subtype-selective expression patterns; CNT1 is localized primarily to epithelial tissue whereas CNT2 and

CNT3 have more widespread distributions. SLC29 family transporters (ENT1-4) are glycosylated proteins,

localized to the plasma and mitochondrial membranes. They are expressed in the heart, brain, mammary gland,

erythrocytes and placenta, and also in fetal liver and spleen. They mediate nucleoside influx and efflux and

exhibit highest affinity for adenosine. CNT and ENT transporters play critical roles in nucleoside salvage

pathways where they mediate the first step of nucleotide biosynthesis. In addition, these transporters work

in concert to terminate adenosine signaling and are vital determinants in the response to a variety of

anticancer and antiviral treatments, as they modulate the entry of these nucleoside analogs into target

tissues.

Gene Wiki entry for SLC29A4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC29A4 gene promoter:
HOXA9 HOXA9B AP-4 GATA-1 HNF-4alpha1 Evi-1 Meis-1b FOXC1 Cart-1 Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC29A4 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC29A4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC29A4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1 Ensembl cytogenetic band: 7p22.1 HGNC cytogenetic band: 7p22.2

SLC29A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC29A4 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P005289: view genomic region (about GC identifiers)

Start:	5,314,000 bp from pter	End:	5,343,704 bp from pter
Size:	29,705 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 5,368,916-5,390,059

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S29A4_HUMAN, Q7RTT9 (See protein sequence)

Recommended Name: Equilibrative nucleoside transporter 4

Size: 530 amino acids; 58059 Da

Subcellular location: Cell membrane; Multi-pass membrane protein (Potential). Apical cell membrane; Multi-pass membrane

protein (Potential). Note=Located to the plasma membranes of ventricular myocytes and vascular endothelial cells.

Targeted to the apical membranes of differentiated kidney epithelial cells

Sequence caution: Sequence=BAC11612.1; Type=Erroneous initiation;

Secondary accessions: Q6PJ08 Q86WY8 Q8NAR3 Q8NBM2

Alternative splicing: 2 isoforms: Q7RTT9-1 Q7RTT9-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC29A4: NX_Q7RTT9

Post-translational modifications:

N-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q7RTT9

SLC29A4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001035751.1 NP_694979.2

ENSEMBL proteins:

ENSP00000406803 ENSP00000380081 ENSP00000413271 ENSP00000297195 ENSP00000385845

Reactome Protein details: Q7RTT9
Human Recombinant Protein Products for SLC29A4:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): SLC29A4 OriGene Custom Protein Services for SLC29A4
	GenScript Custom Purified and Recombinant Proteins Services for SLC29A4
	Novus Biologicals SLC29A4 Protein Novus Biologicals SLC29A4 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SLC29A4

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--
GO:0016324	apical plasma membrane	IEA	--

SLC29A4 for ontologies About GeneDecksing

SLC29A4 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for SLC29A4
	GenScript Custom Superior Antibodies Services for SLC29A4
	Novus Biologicals SLC29A4 Antibodies
	Abcam antibodies for SLC29A4
	Uscn Antibodies for SLC29A4
	ThermoFisher Antibody for SLC29A4

Assay Products for SLC29A4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SLC29A4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SLC29A4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC29A4 for domains About GeneDecksing

2 InterPro domains/families:

IPR002259 Eqnu_transpt

IPR016196 MFS_dom_general_subst_transpt

Graphical View of Domain Structure for InterPro Entry Q7RTT9

ProtoNet protein and cluster: Q7RTT9

1 Blocks protein family: IPB002259 Delayed-early response protein/equilibrative nucleoside transporter signature

UniProtKB/Swiss-Prot: S29A4_HUMAN, Q7RTT9

Similarity: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: S29A4_HUMAN, Q7RTT9