Aliases for SLC29A3 Gene
Aliases for SLC29A3 Gene
External Ids for SLC29A3 Gene
- HGNC: 23096
- Entrez Gene: 55315
- Ensembl: ENSG00000198246
- OMIM: 612373
- UniProtKB: Q9BZD2
Previous GeneCards Identifiers for SLC29A3 Gene
- GC10P072971
- GC10P072427
- GC10P072423
- GC10P072749
- GC10P073080
- GC10P067074
Summaries for SLC29A3 Gene
-
This gene encodes a nucleoside transporter. The encoded protein plays a role in cellular uptake of nucleosides, nucleobases, and their related analogs. Mutations in this gene have been associated with H syndrome, which is characterized by cutaneous hyperpigmentation and hypertrichosis, hepatosplenomegaly, heart anomalies, and hypogonadism. A related disorder, PHID (pigmented hypertrichosis with insulin-dependent diabetes mellitus), has also been associated with mutations at this locus. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2010]
GeneCards Summary for SLC29A3 Gene
SLC29A3 (Solute Carrier Family 29 Member 3) is a Protein Coding gene. Diseases associated with SLC29A3 include Histiocytosis-Lymphadenopathy Plus Syndrome and Dysosteosclerosis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of vitamins, nucleosides, and related molecules. GO annotations related to this gene include nucleoside transmembrane transporter activity. An important paralog of this gene is SLC29A1.
UniProtKB/Swiss-Prot for SLC29A3 Gene
-
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine, as well as several nucleoside analog drugs, such as anticancer and antiviral agents, including cladribine, cordycepin, tubercidin and AZT. Does not transport hypoxanthine.
-
Nucleoside transporters are divided into two families: the Na+-dependent solute carrier family 28 (SLC28) and the equilibrative solute carrier family 29 (SLC29). SLC28 family transporters (CNT1, 2 and 3) display subtype-selective tissue expression patterns.
No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC29A3 Gene
Genomics for SLC29A3 Gene
Regulatory Elements for SLC29A3 Gene
Enhancers for SLC29A3 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around SLC29A3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the SLC29A3 gene promoter:
Regulatory Element Products
Genomic Location for SLC29A3 Gene
- Chromosome:
- 10
- Start:
- 71,319,253 bp from pter
- End:
- 71,363,396 bp from pter
- Size:
- 44,144 bases
- Orientation:
- Plus strand
Genomic View for SLC29A3 Gene
Genes around SLC29A3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q22.1 by Ensembl
- 10q22.1 by Entrez Gene
- 10q22.1 by HGNC
SLC29A3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC29A3 Gene
Proteins for SLC29A3 Gene
-
Protein details for SLC29A3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BZD2-S29A3_HUMAN
- Recommended name:
- Equilibrative nucleoside transporter 3
- Protein Accession:
- Q9BZD2
- B2RB50
- B4E2Z9
- B7ZA37
- Q0VAM9
- Q5T465
- Q7RTT8
- Q8IVZ0
- Q9BWI2
- Q9NUS9
Protein attributes for SLC29A3 Gene
- Size:
- 475 amino acids
- Molecular mass:
- 51815 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA92041.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for SLC29A3 Gene
Post-translational modifications for SLC29A3 Gene
Other Protein References for SLC29A3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for SLC29A3
- Novus Biologicals Antibodies for SLC29A3
-
Abcam antibodies for SLC29A3
- Invitrogen Antibodies for SLC29A3
- antibodies-online Antibodies for SLC29A3: See all 22
- GeneTex SLC29A3 antibody for SLC29A3
-
Custom Antibody ServicesProSci Antibodies for SLC29A3
Protein Products
-
OriGene Purified Proteins for SLC29A3
- Search Origene for MassSpec and Protein Over-expression Lysates for SLC29A3
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- Search GeneTex for Proteins for SLC29A3
Assay Products
No data available for DME Specific Peptides for SLC29A3 Gene
Domains & Families for SLC29A3 Gene
Gene Families for SLC29A3 Gene
- HGNC:
- IUPHAR :
Protein Domains for SLC29A3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC29A3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BZD2- Family:
-
- Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
Function for SLC29A3 Gene
Molecular function for SLC29A3 Gene
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=1.86 mM for adenosine {ECO:0000269 PubMed:15701636}; KM=2.02 mM for uridine {ECO:0000269 PubMed:15701636}; pH dependence: Optimum pH is 5.5 for adenosine uptake. {ECO:0000269 PubMed:15701636};
- UniProtKB/Swiss-Prot Function:
- Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine, as well as several nucleoside analog drugs, such as anticancer and antiviral agents, including cladribine, cordycepin, tubercidin and AZT. Does not transport hypoxanthine.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005337 | nucleoside transmembrane transporter activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 25910212 |
Phenotypes for SLC29A3 Gene
- MGI mutant phenotypes for SLC29A3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SLC29A3:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability in esophageal squamous lineage
- Decreased viability ratio
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased shRNA abundance
- Increased viability with SS1P at EC90
- Decreased Salmonella proliferation
- Increased Sindbis virus (SINV) infection
Animal Models for SLC29A3 Gene
- MGI Knock Outs for SLC29A3:
-
- Slc29a3 tm1Lex
Animal Model Products
-
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for SLC29A3 gene
-
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- Search ViGene Biosciences for SLC29A3
CRISPR Products
-
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-
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miRNA for SLC29A3 Gene
- miRTarBase miRNAs that target SLC29A3
miRNA Products
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Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for SLC29A3
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ViGene Biosciences ready-to-package AAV shRNAs for SLC29A3 gene
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SLC29A3
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for SLC29A3
-
ViGene Biosciences adenoviral particle packaged cDNA for SLC29A3 gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SLC29A3 Gene
Localization for SLC29A3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC29A3 Gene
- Membrane; Multi-pass membrane protein. Late endosome membrane. Lysosome membrane. Note=Observed in a punctate intracellular pattern showing partial colocalization with late endosomes/lysosomes. Not detected at the cell surface.
| Compartment | Confidence |
|---|---|
| lysosome | 5 |
| golgi apparatus | 5 |
| endosome | 5 |
| plasma membrane | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005764 | lysosome | IEA | -- |
| GO:0005765 | lysosomal membrane | TAS | -- |
| GO:0005768 | endosome | IEA | -- |
| GO:0005794 | Golgi apparatus | IDA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for SLC29A3 Gene
Pathways by source for SLC29A3 Gene
Interacting Proteins for SLC29A3 Gene
Selected Interacting proteins:
Q9BZD2-S29A3_HUMAN
ENSP00000362285
for SLC29A3 Gene via
IID
UniProtKB
STRING
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0015858 | nucleoside transport | IEA | -- |
| GO:1901642 | nucleoside transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for SLC29A3 Gene
Drugs & Compounds for SLC29A3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Adenine | Approved | Nutra | 0 | |||
| Dipyridamole | Approved | Pharma | Inhibition, Inhibitor | Adenosine transport inhibitor | 83 | |
| Decynium 22 | Pharma | PMAT inhibitor | 0 | |||
| Dilazep dihydrochloride | Pharma | Adenosine uptake inhibitor | 0 | |||
| NBMPR | Pharma | Equilibrative nucleoside transporter 1 (ENT1) inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 8MDP |
|
29491-75-6 |
|
|
(5) Tocris Compounds for SLC29A3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 8MDP | Potent equilibrative nucleoside transporter (ENT) inhibitor | 29491-75-6 |
| Decynium 22 | PMAT inhibitor | 977-96-8 |
| Dilazep dihydrochloride | Adenosine uptake inhibitor | 20153-98-4 |
| Dipyridamole | Adenosine transport inhibitor | 58-32-2 |
| NBMPR | Equilibrative nucleoside transporter 1 (ENT1) inhibitor | 38048-32-7 |
Transcripts for SLC29A3 Gene
mRNA/cDNA for SLC29A3 Gene
- (5) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (86) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SLC29A3 Gene
- Solute carrier family 29 (nucleoside transporters), member 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for SLC29A3
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC29A3
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miRNA Products
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Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for SLC29A3
- Browse OriGene Inhibitory RNA Products For SLC29A3
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC29A3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SLC29A3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SLC29A3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||
| SP2: | |||||||||||||||||||
| SP3: | - | - | |||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||
| SP5: | |||||||||||||||||||
| SP6: | - |
Expression for SLC29A3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Lung (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC29A3 Gene
NURSA nuclear receptor signaling pathways regulating expression of SLC29A3 Gene:
SLC29A3SOURCE GeneReport for Unigene cluster for SLC29A3 Gene:
Hs.438419mRNA Expression by UniProt/SwissProt for SLC29A3 Gene:
Q9BZD2-S29A3_HUMAN
Tissue specificity:
Widely expressed in both adult and fetal tissues. Highest levels in placenta, uterus, ovary, spleen, lymph node and bone marrow. Lowest levels in brain and heart.
Evidence on tissue expression from TISSUES for SLC29A3 Gene
- Skin(4.3)
- Intestine(4.2)
- Kidney(4.2)
- Eye(4)
- Nervous system(2.3)
Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC29A3 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Organs:
Head and neck:
- brain
- cheek
- chin
- cranial nerve
- ear
- eye
- eyelid
- face
- forehead
- head
- jaw
- mandible
- maxilla
- mouth
- neck
- pituitary gland
- sinus
- skull
- tooth
Thorax:
- breast
- chest wall
- clavicle
- heart
- lung
- rib
- rib cage
- scapula
- sternum
Abdomen:
- kidney
- liver
- pancreas
- spleen
Pelvis:
- ovary
- pelvis
- penis
- prostate
- testicle
- uterus
- vagina
- vulva
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- hair
- lymph node
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for SLC29A3
-
OriGene qPCR primer pairs and template standards for SLC29A3
No data available for mRNA differential expression in normal tissues for SLC29A3 Gene
Orthologs for SLC29A3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SLC29A3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | SLC29A3 34 35 |
|
||
| -- 35 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | SLC29A3 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Slc29a3 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Slc29a3 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SLC29A3 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SLC29A3 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | SLC29A3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | slc29a3 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC101887173 34 |
|
||
| slc29a3 35 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Ent1 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | ent-1 35 |
|
ManyToMany |
- Species where no ortholog for SLC29A3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SLC29A3 Gene
Variants for SLC29A3 Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs121912583 | Pathogenic, Histiocytosis-lymphadenopathy plus syndrome (HLAS) [MIM:602782] | 71,362,459(+) | GCAAC(A/G)GCTAC | nc-transcript-variant, reference, missense, utr-variant-3-prime | |
| rs121912584 | Pathogenic, Histiocytosis-lymphadenopathy plus syndrome (HLAS) [MIM:602782] | 71,362,489(+) | TCTAC(A/G)GGCCT | nc-transcript-variant, reference, missense, utr-variant-3-prime | |
| rs267607057 | Pathogenic, Histiocytosis-lymphadenopathy plus syndrome (HLAS) [MIM:602782] | 71,344,255(+) | CTCCA(G/T)GCTGT | intron-variant, upstream-variant-2KB, reference, missense | |
| rs267607058 | Pathogenic, Histiocytosis-lymphadenopathy plus syndrome (HLAS) [MIM:602782] | 71,362,526(+) | GGCCA(C/G/T)GGGAG | nc-transcript-variant, reference, missense, utr-variant-3-prime | |
| rs387907066 | Pathogenic, Histiocytosis-lymphadenopathy plus syndrome (HLAS) [MIM:602782] | 71,362,268(+) | TGGCC(A/G)GCAGC | nc-transcript-variant, reference, missense, utr-variant-3-prime |
Residual Variation Intolerance Score:
90.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
18.55;
98.60% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for SLC29A3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC29A3 Gene
Disorders for SLC29A3 Gene
(14) MalaCards diseases for SLC29A3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| histiocytosis-lymphadenopathy plus syndrome |
|
|
| dysosteosclerosis |
|
|
| hypertrichosis |
|
|
| histiocytosis |
|
|
| middle ear disease |
|
|
Search SLC29A3 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
S29A3_HUMAN- Histiocytosis-lymphadenopathy plus syndrome (HLAS) [MIM:602782]: A syndrome characterized by the combination of features from 2 or more of four histiocytic disorders, originally thought to be distinct: Faisalabad histiocytosis (FHC), sinus histiocytosis with massive lymphadenopathy (SHML), H syndrome, and pigmented hypertrichosis with insulin-dependent diabetes mellitus syndrome (PHID). FHC features include joint deformities, sensorineural hearing loss, and subsequent development of generalized lymphadenopathy and swellings in the eyelids that contain histiocytes. SHML causes lymph node enlargement in children frequently accompanied by fever, leukocytosis, elevated erythrocyte sedimentation rate, and polyclonal hypergammaglobulinemia. H syndrome is characterized by cutaneous hyperpigmentation and hypertrichosis, hepatosplenomegaly, heart anomalies, and hypogonadism; hearing loss is found in about half of patients. PHID is characterized by predominantly antibody-negative insulin-dependent diabetes mellitus associated with pigmented hypertrichosis and variable occurrence of other features of H syndrome. {ECO:0000269 PubMed:18940313, ECO:0000269 PubMed:19336477, ECO:0000269 PubMed:19889517, ECO:0000269 PubMed:20140240, ECO:0000269 PubMed:20199539, ECO:0000269 PubMed:20399510, ECO:0000269 PubMed:20595384, ECO:0000269 PubMed:20619369, ECO:0000269 PubMed:21888995}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for SLC29A3
No data available for Genatlas for SLC29A3 Gene
Publications for SLC29A3 Gene
- The H syndrome is caused by mutations in the nucleoside transporter hENT3. (PMID: 18940313) Molho-Pessach V. … Zlotogorski A. (Am. J. Hum. Genet. 2008) 3 4 22 64
- The ENT family of eukaryote nucleoside and nucleobase transporters: recent advances in the investigation of structure/function relationships and the identification of novel isoforms. (PMID: 11396612) Hyde R.J. … Baldwin S.A. (Mol. Membr. Biol. 2001) 2 3 4 64
- The H syndrome: two novel mutations affecting the same amino acid residue of hENT3. (PMID: 19889517) Molho-Pessach V. … Zlotogorski A. (J. Dermatol. Sci. 2010) 3 4 64
- Mutations in SLC29A3, encoding an equilibrative nucleoside transporter ENT3, cause a familial histiocytosis syndrome (Faisalabad histiocytosis) and familial Rosai-Dorfman disease. (PMID: 20140240) Morgan N.V. … Maher E.R. (PLoS Genet. 2010) 3 4 64
- H syndrome: novel and recurrent mutations in SLC29A3. (PMID: 20199539) Priya T.P. … Zlotogorski A. (Br. J. Dermatol. 2010) 3 4 64
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- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for SLC29A3
- Novus Biologicals proteins and lysates for SLC29A3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for SLC29A3
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- ViGene Biosciences adenoviral particle packaged cDNA for SLC29A3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SLC29A3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SLC29A3 gene
- Search ViGene Biosciences for SLC29A3
- Custom Antibody ServicesProSci Antibodies for SLC29A3
- Search for SLC29A3 Proteins at ProSci
- Horizon Cell Lines for SLC29A3
- Cyagen custom Knockout/knockin (KOKI) mouse models for SLC29A3
- VectorBuilder custom plasmid, inducible vectors for SLC29A3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SLC29A3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for SLC29A3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer