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Aliases for SLC29A2 Gene

Aliases for SLC29A2 Gene

  • Solute Carrier Family 29 Member 2 2 3 4 5
  • Equilibrative Nitrobenzylmercaptopurine Riboside-Insensitive Nucleoside Transporter 3 4
  • Solute Carrier Family 29 (Equilibrative Nucleoside Transporter), Member 2 2 3
  • Equilibrative NBMPR-Insensitive Nucleoside Transporter 3 4
  • Hydrophobic Nucleolar Protein, 36 KDa 3 4
  • Delayed-Early Response Protein 12 3 4
  • Nucleoside Transporter, Ei-Type 3 4
  • 36 KDa Nucleolar Protein HNP36 3 4
  • HNP36 3 4
  • DER12 3 4
  • ENT2 3 4
  • Solute Carrier Family 29 (Nucleoside Transporters), Member 2 3
  • Equilibrative Nucleoside Transporter 2 3
  • Hydrophobic Nucleolar Protein, 36kD 3

External Ids for SLC29A2 Gene

Previous HGNC Symbols for SLC29A2 Gene

  • ENT2
  • HNP36

Previous GeneCards Identifiers for SLC29A2 Gene

  • GC11M068664
  • GC11M067811
  • GC11M066379
  • GC11M065905
  • GC11M065886
  • GC11M066129
  • GC11M062455

Summaries for SLC29A2 Gene

Entrez Gene Summary for SLC29A2 Gene

  • The uptake of nucleosides by transporters, such as SLC29A2, is essential for nucleotide synthesis by salvage pathways in cells that lack de novo biosynthetic pathways. Nucleoside transport also plays a key role in the regulation of many physiologic processes through its effect on adenosine concentration at the cell surface (Griffiths et al., 1997 [PubMed 9396714]).[supplied by OMIM, Nov 2008]

GeneCards Summary for SLC29A2 Gene

SLC29A2 (Solute Carrier Family 29 Member 2) is a Protein Coding gene. Among its related pathways are Transport of vitamins, nucleosides, and related molecules and Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics. GO annotations related to this gene include nucleoside transmembrane transporter activity. An important paralog of this gene is SLC29A1.

UniProtKB/Swiss-Prot for SLC29A2 Gene

  • Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine.

Tocris Summary for SLC29A2 Gene

  • Nucleoside transporters are divided into two families: the Na+-dependent solute carrier family 28 (SLC28) and the equilibrative solute carrier family 29 (SLC29). SLC28 family transporters (CNT1, 2 and 3) display subtype-selective tissue expression patterns.

Gene Wiki entry for SLC29A2 Gene

Additional gene information for SLC29A2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC29A2 Gene

Genomics for SLC29A2 Gene

Regulatory Elements for SLC29A2 Gene

Enhancers for SLC29A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H066324 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +45.6 45621 5.4 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ZNF143 RIN1 ACTN3 YIF1A TMEM151A LOC100505504 SLC29A2 ENSG00000255320 PACS1 ENSG00000201733 CTSF
GH11H066408 1 ENCODE 11.3 -37.3 -37320 2.8 ATF1 ARID4B SIN3A ZNF2 GLIS2 ZNF143 ATF7 RUNX3 DEK MIER2 RIN1 ACTN3 ENSG00000201733 SLC29A2 MRPL11 PELI3 LOC101928069 DPP3 ENSG00000255320 PACS1
GH11H066369 1.1 ENCODE 0.7 +1.2 1160 4.5 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZBTB7B ZNF766 ZNF143 SP3 EIF1AD ENSG00000258297 PCNX3 KDM2A RBM4 RBM14 SART1 RAD9A FRMD8 ENSG00000245156
GH11H066359 0.7 ENCODE 0.4 +12.6 12632 0.2 ESRRA NR2F1 USF2 RARA POLR2A MYNN NFYB NR2C1 NR2F6 KDM1A RIN1 GC11P066354 SLC29A2
GH11H066363 0.6 ENCODE 0.4 +8.4 8392 0.2 CTCF RB1 TRIM22 RAD21 CBX1 POLR2A NCOR1 ZNF143 SUPT5H GC11P066354 SLC29A2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC29A2 on UCSC Golden Path with GeneCards custom track

Promoters for SLC29A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040963 876 2001 PKNOX1 ARNT SIN3A ZBTB7B ZNF766 CBX5 ZNF143 SP3 SP5 REST

Genomic Locations for SLC29A2 Gene

Genomic Locations for SLC29A2 Gene
9,956 bases
Minus strand

Genomic View for SLC29A2 Gene

Genes around SLC29A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC29A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC29A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC29A2 Gene

Proteins for SLC29A2 Gene

  • Protein details for SLC29A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Equilibrative nucleoside transporter 2
    Protein Accession:
    Secondary Accessions:
    • B3KPY7
    • O43530
    • Q52M84
    • Q96R00
    • Q9UPE0

    Protein attributes for SLC29A2 Gene

    456 amino acids
    Molecular mass:
    50113 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAA60380.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC29A2 Gene


neXtProt entry for SLC29A2 Gene

Post-translational modifications for SLC29A2 Gene

  • Glycosylation at isoforms=2, 348, isoforms=2, 357, and Asn225
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC29A2 Gene

Domains & Families for SLC29A2 Gene

Gene Families for SLC29A2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for SLC29A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
  • Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
genes like me logo Genes that share domains with SLC29A2: view

Function for SLC29A2 Gene

Molecular function for SLC29A2 Gene

GENATLAS Biochemistry:
solute carrier family 29,member A2,equilibrative nucleoside transporter,growth factor responsive,delayed early response gene of unknown function,expressed in pituitary and parathyroid glands,not mutated in MEN1
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.2 mM for uridine {ECO:0000269 PubMed:12527552, ECO:0000269 PubMed:9396714}; KM=0.75 mM for adenosine {ECO:0000269 PubMed:12527552, ECO:0000269 PubMed:9396714}; Note=Vmax for adenosine uptake is about the same for SLC29A1 and SLC29A2.;
UniProtKB/Swiss-Prot Function:
Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine.
UniProtKB/Swiss-Prot Induction:
By PDGF/platelet derived growth factor and fibroblast growth factor (FGF).

Phenotypes From GWAS Catalog for SLC29A2 Gene

Gene Ontology (GO) - Molecular Function for SLC29A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005337 nucleoside transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLC29A2: view
genes like me logo Genes that share phenotypes with SLC29A2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC29A2 Gene

Localization for SLC29A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC29A2 Gene

Basolateral cell membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein. Note=Localized at the basolateral cell membrane in polarized MDCK cells.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC29A2 gene
Compartment Confidence
plasma membrane 5
nucleus 5
extracellular 2
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC29A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus TAS 7639753
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC29A2: view

Pathways & Interactions for SLC29A2 Gene

genes like me logo Genes that share pathways with SLC29A2: view

Interacting Proteins for SLC29A2 Gene

Gene Ontology (GO) - Biological Process for SLC29A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 9396714
GO:0006810 transport IEA --
GO:0008283 cell proliferation TAS 7639753
GO:0015858 nucleoside transport IEA,IDA 12527552
GO:1901642 nucleoside transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC29A2: view

No data available for SIGNOR curated interactions for SLC29A2 Gene

Drugs & Compounds for SLC29A2 Gene

(18) Drugs for SLC29A2 Gene - From: DrugBank, ApexBio, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Target 2226
Didanosine Approved Pharma Transporter 150
Gemcitabine Approved Pharma Transporter Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 2049
Mercaptopurine Approved Pharma Transporter, substrate 0
Zalcitabine Approved Pharma Transporter 47

(5) Additional Compounds for SLC29A2 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) Tocris Compounds for SLC29A2 Gene

Compound Action Cas Number
8MDP Potent equilibrative nucleoside transporter (ENT) inhibitor 29491-75-6
Dilazep dihydrochloride Adenosine uptake inhibitor 20153-98-4
Dipyridamole Adenosine transport inhibitor 58-32-2
NBMPR Equilibrative nucleoside transporter 1 (ENT1) inhibitor 38048-32-7

(3) ApexBio Compounds for SLC29A2 Gene

Compound Action Cas Number
Decynium 22 977-96-8
Dilazep dihydrochloride 20153-98-4
NBMPR 38048-32-7
genes like me logo Genes that share compounds with SLC29A2: view

Drug Products

Transcripts for SLC29A2 Gene

Unigene Clusters for SLC29A2 Gene

Solute carrier family 29 (nucleoside transporters), member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC29A2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e · 3f · 3g · 3h ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - - - -
SP9: - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - -
SP12: - - -
SP13: - - - - -
SP14: - -
SP15: -
SP17: -

ExUns: 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17
SP1: - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - -
SP7: -
SP8: -
SP18: - - - - - -

Relevant External Links for SLC29A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC29A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC29A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC29A2 Gene

This gene is overexpressed in Muscle - Skeletal (x12.7).

Protein differential expression in normal tissues from HIPED for SLC29A2 Gene

This gene is overexpressed in Fetal Liver (36.3) and Retina (32.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC29A2 Gene

Protein tissue co-expression partners for SLC29A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC29A2 Gene:


SOURCE GeneReport for Unigene cluster for SLC29A2 Gene:


mRNA Expression by UniProt/SwissProt for SLC29A2 Gene:

Tissue specificity: Expressed in skeletal muscle, liver, lung, placenta, brain, heart, kidney and ovarian tissues.

Evidence on tissue expression from TISSUES for SLC29A2 Gene

  • Heart(4.4)
  • Liver(4.2)
  • Muscle(2.7)
  • Intestine(2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with SLC29A2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC29A2 Gene

Orthologs for SLC29A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC29A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC29A2 33 34
  • 99.05 (n)
(Bos Taurus)
Mammalia SLC29A2 33 34
  • 90.18 (n)
(Canis familiaris)
Mammalia SLC29A2 33 34
  • 90.11 (n)
(Mus musculus)
Mammalia Slc29a2 33 16 34
  • 87.42 (n)
(Monodelphis domestica)
Mammalia SLC29A2 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia SLC29A2 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc29a2 33
  • 63.03 (n)
(Danio rerio)
Actinopterygii slc29a2 33 34
  • 57.11 (n)
SLC29A2 (2 of 2) 34
  • 56 (a)
zgc63618 33
fruit fly
(Drosophila melanogaster)
Insecta Ent1 34
  • 30 (a)
BEST:LD04971 35
  • 29 (a)
(Caenorhabditis elegans)
Secernentea ent-4 34
  • 23 (a)
ent-5 34
  • 23 (a)
ent-6 34
  • 23 (a)
ent-3 34
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
Species where no ortholog for SLC29A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC29A2 Gene

Gene Tree for SLC29A2 (if available)
Gene Tree for SLC29A2 (if available)

Paralogs for SLC29A2 Gene

Paralogs for SLC29A2 Gene

(2) SIMAP similar genes for SLC29A2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC29A2: view

Variants for SLC29A2 Gene

Sequence variations from dbSNP and Humsavar for SLC29A2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000180735 -- 66,362,107(+) CAGGG(C/T)AGTAT intron-variant, downstream-variant-500B
rs1000230951 -- 66,362,474(+) AGGCC(A/T)ATAGA intron-variant, downstream-variant-500B
rs1000266554 -- 66,370,121(+) TGATC(A/G)TCTCT intron-variant, upstream-variant-2KB
rs1000835181 -- 66,372,431(+) AGAGG(A/C)TCCAA nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000926450 -- 66,372,701(+) GGTCT(C/T)GAACT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC29A2 Gene

Variant ID Type Subtype PubMed ID
nsv832193 CNV loss 17160897
esv3626693 CNV loss 21293372

Variation tolerance for SLC29A2 Gene

Residual Variation Intolerance Score: 36.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC29A2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC29A2 Gene

Disorders for SLC29A2 Gene

Relevant External Links for SLC29A2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC29A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC29A2 Gene

Publications for SLC29A2 Gene

  1. Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line. (PMID: 9478986) Crawford CR … Belt JA (The Journal of biological chemistry 1998) 2 3 4 22 60
  2. Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2. (PMID: 16214850) Owen RP … Giacomini KM (Drug metabolism and disposition: the biological fate of chemicals 2006) 3 4 22 60
  3. Functional analysis of site-directed glycosylation mutants of the human equilibrative nucleoside transporter-2. (PMID: 12590919) Ward JL … Tse CM (Archives of biochemistry and biophysics 2003) 3 4 22 60
  4. A mammalian delayed-early response gene encodes HNP36, a novel, conserved nucleolar protein. (PMID: 7639753) Williams JB … Lanahan AA (Biochemical and biophysical research communications 1995) 3 4 22 60
  5. Contribution of adenosine related genes to the risk of depression with disturbed sleep. (PMID: 20392501) Gass N … Paunio T (Journal of affective disorders 2010) 3 45 60

Products for SLC29A2 Gene

Sources for SLC29A2 Gene

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