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Aliases for SLC29A2 Gene

Aliases for SLC29A2 Gene

  • Solute Carrier Family 29 (Equilibrative Nucleoside Transporter), Member 2 2 3
  • HNP36 3 4 6
  • DER12 3 4 6
  • Equilibrative Nitrobenzylmercaptopurine Riboside-Insensitive Nucleoside Transporter 3 4
  • Solute Carrier Family 29 (Nucleoside Transporters), Member 2 2 3
  • Equilibrative NBMPR-Insensitive Nucleoside Transporter 3 4
  • Hydrophobic Nucleolar Protein, 36 KDa 3 4
  • Delayed-Early Response Protein 12 3 4
  • Solute Carrier Family 29 Member 2 3 4
  • Nucleoside Transporter, Ei-Type 3 4
  • 36 KDa Nucleolar Protein HNP36 3 4
  • ENT2 3 4
  • Equilibrative Nucleoside Transporter 2 3
  • Hydrophobic Nucleolar Protein, 36kD 3

External Ids for SLC29A2 Gene

Previous HGNC Symbols for SLC29A2 Gene

  • ENT2
  • HNP36

Previous GeneCards Identifiers for SLC29A2 Gene

  • GC11M068664
  • GC11M067811
  • GC11M066379
  • GC11M065905
  • GC11M065886
  • GC11M066129
  • GC11M062455

Summaries for SLC29A2 Gene

Entrez Gene Summary for SLC29A2 Gene

  • The uptake of nucleosides by transporters, such as SLC29A2, is essential for nucleotide synthesis by salvage pathways in cells that lack de novo biosynthetic pathways. Nucleoside transport also plays a key role in the regulation of many physiologic processes through its effect on adenosine concentration at the cell surface (Griffiths et al., 1997 [PubMed 9396714]).[supplied by OMIM, Nov 2008]

GeneCards Summary for SLC29A2 Gene

SLC29A2 (Solute Carrier Family 29 (Equilibrative Nucleoside Transporter), Member 2) is a Protein Coding gene. Diseases associated with SLC29A2 include hyperglycemia and chronic lymphocytic leukemia. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and One carbon pool by folate. GO annotations related to this gene include nucleoside transmembrane transporter activity. An important paralog of this gene is SLC29A3.

UniProtKB/Swiss-Prot for SLC29A2 Gene

  • Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine.

Tocris Summary for SLC29A2 Gene

  • Nucleoside transporters are divided into two families; the Na+-dependent solute carrier family 28 (SLC28) and the equilibrative solute carrier family 29 (SLC29). SLC28 family transporters (CNT1-3) display subtype-selective expression patterns; CNT1 is localized primarily to epithelial tissue whereas CNT2 and CNT3 have more widespread distributions. SLC29 family transporters (ENT1-4) are glycosylated proteins, localized to the plasma and mitochondrial membranes. They are expressed in the heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen. They mediate nucleoside influx and efflux and exhibit highest affinity for adenosine. CNT and ENT transporters play critical roles in nucleoside salvage pathways where they mediate the first step of nucleotide biosynthesis. In addition, these transporters work in concert to terminate adenosine signaling and are vital determinants in the response to a variety of anticancer and antiviral treatments, as they modulate the entry of these nucleoside analogs into target tissues.

Gene Wiki entry for SLC29A2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC29A2 Gene

Genomics for SLC29A2 Gene

Regulatory Elements for SLC29A2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC29A2 Gene

66,362,521 bp from pter
66,372,265 bp from pter
9,745 bases
Minus strand

Genomic View for SLC29A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC29A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC29A2 Gene

Proteins for SLC29A2 Gene

  • Protein details for SLC29A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Equilibrative nucleoside transporter 2
    Protein Accession:
    Secondary Accessions:
    • B3KPY7
    • O43530
    • Q52M84
    • Q96R00
    • Q9UPE0

    Protein attributes for SLC29A2 Gene

    456 amino acids
    Molecular mass:
    50113 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAA60380.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC29A2 Gene


neXtProt entry for SLC29A2 Gene

Proteomics data for SLC29A2 Gene at MOPED

Post-translational modifications for SLC29A2 Gene

  • Glycosylation at Asn48, Asn57, and Asn225
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC29A2 Gene

No data available for DME Specific Peptides for SLC29A2 Gene

Domains for SLC29A2 Gene

Gene Families for SLC29A2 Gene

  • SLC :Solute carriers

Suggested Antigen Peptide Sequences for SLC29A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q14542
  • Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
genes like me logo Genes that share domains with SLC29A2: view

Function for SLC29A2 Gene

Molecular function for SLC29A2 Gene

GENATLAS Biochemistry:
solute carrier family 29,member A2,equilibrative nucleoside transporter,growth factor responsive,delayed early response gene of unknown function,expressed in pituitary and parathyroid glands,not mutated in MEN1
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.2 mM for uridine {ECO:0000269 PubMed:12527552, ECO:0000269 PubMed:9396714}; KM=0.75 mM for adenosine {ECO:0000269 PubMed:12527552, ECO:0000269 PubMed:9396714}; Note=Vmax for adenosine uptake is about the same for SLC29A1 and SLC29A2.;
UniProtKB/Swiss-Prot Function:
Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine.
UniProtKB/Swiss-Prot Induction:
By PDGF/platelet derived growth factor and fibroblast growth factor (FGF)

Gene Ontology (GO) - Molecular Function for SLC29A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005337 nucleoside transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC29A2: view

Animal Model Products

CRISPR Products

miRNA for SLC29A2 Gene

miRTarBase miRNAs that target SLC29A2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC29A2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC29A2 Gene

Localization for SLC29A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC29A2 Gene

Basolateral cell membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein. Note=Localized at the basolateral cell membrane in polarized MDCK cells.

Subcellular locations from

Jensen Localization Image for SLC29A2 Gene COMPARTMENTS Subcellular localization image for SLC29A2 gene
Compartment Confidence
nucleus 5
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for SLC29A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus TAS 7639753
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016021 integral component of membrane --
GO:0016323 basolateral plasma membrane IDA 12527552
genes like me logo Genes that share ontologies with SLC29A2: view

Pathways for SLC29A2 Gene

genes like me logo Genes that share pathways with SLC29A2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for SLC29A2 Gene

Gene Ontology (GO) - Biological Process for SLC29A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 9396714
GO:0006810 transport --
GO:0008283 cell proliferation TAS 7639753
GO:0015858 nucleoside transport IDA 12527552
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC29A2: view

Compounds for SLC29A2 Gene

(4) Tocris Compounds for SLC29A2 Gene

Compound Action Cas Number
Decynium 22 PMAT inhibitor [977-96-8]
Dilazep dihydrochloride Adenosine uptake inhibitor [20153-98-4]
Dipyridamole Adenosine transport inhibitor [58-32-2]
NBMPR Equilibrative nucleoside transporter 1 (ENT1) inhibitor [38048-32-7]

(2) HMDB Compounds for SLC29A2 Gene

Compound Synonyms Cas Number PubMed IDs
  • 1,6-Dihydro-6-iminopurine
  • 1,7-Dihydro-6H-purin-6-one

(1) IUPHAR Ligand for SLC29A2 Gene

Ligand Type Action Affinity Pubmed IDs
[14C]adenosine None None

(10) Novoseek inferred chemical compound relationships for SLC29A2 Gene

Compound -log(P) Hits PubMed IDs
nitrobenzylthioinosine 91.4 2
nucleoside 87.2 41
dipyridamole 75.2 3
uridine 70.3 2
cytidine 53.2 1
genes like me logo Genes that share compounds with SLC29A2: view

Transcripts for SLC29A2 Gene

Unigene Clusters for SLC29A2 Gene

Solute carrier family 29 (nucleoside transporters), member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC29A2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC29A2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e · 3f · 3g · 3h ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - - - -
SP9: - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - -
SP12: - - -
SP13: - - - - -
SP14: - -
SP15: -
SP17: -

ExUns: 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17
SP1: - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - -
SP7: -
SP8: -
SP18: - - - - - -

Relevant External Links for SLC29A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC29A2 Gene

mRNA expression in normal human tissues for SLC29A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC29A2 Gene

This gene is overexpressed in Muscle - Skeletal (12.7).

Protein differential expression in normal tissues for SLC29A2 Gene

This gene is overexpressed in Fetal Liver (36.3) and Retina (32.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC29A2 Gene

SOURCE GeneReport for Unigene cluster for SLC29A2 Gene Hs.569017

mRNA Expression by UniProt/SwissProt for SLC29A2 Gene

Tissue specificity: Expressed in skeletal muscle, liver, lung, placenta, brain, heart, kidney and ovarian tissues.
genes like me logo Genes that share expressions with SLC29A2: view

Expression partners for SLC29A2 Gene

In Situ Assay Products

Orthologs for SLC29A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC29A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC29A2 35
  • 90.18 (n)
  • 90.11 (a)
SLC29A2 36
  • 87 (a)
(Canis familiaris)
Mammalia SLC29A2 35
  • 90.11 (n)
  • 91.43 (a)
SLC29A2 36
  • 91 (a)
(Mus musculus)
Mammalia Slc29a2 35
  • 87.42 (n)
  • 89.62 (a)
Slc29a2 16
Slc29a2 36
  • 89 (a)
(Pan troglodytes)
Mammalia SLC29A2 35
  • 99.05 (n)
  • 99.12 (a)
SLC29A2 36
  • 99 (a)
(Monodelphis domestica)
Mammalia SLC29A2 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia SLC29A2 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc29a2 35
  • 63.03 (n)
  • 62.14 (a)
(Danio rerio)
Actinopterygii slc29a2 35
  • 57.11 (n)
  • 55.24 (a)
zgc63618 35
slc29a2 36
  • 50 (a)
SLC29A2 (2 of 2) 36
  • 56 (a)
fruit fly
(Drosophila melanogaster)
Insecta BEST:LD04971 37
  • 29 (a)
Ent1 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea ent-3 36
  • 15 (a)
ent-4 36
  • 23 (a)
ent-5 36
  • 23 (a)
ent-6 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for SLC29A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC29A2 Gene

Gene Tree for SLC29A2 (if available)
Gene Tree for SLC29A2 (if available)

Paralogs for SLC29A2 Gene

Paralogs for SLC29A2 Gene

Selected SIMAP similar genes for SLC29A2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC29A2: view

Variants for SLC29A2 Gene

Sequence variations from dbSNP and Humsavar for SLC29A2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1344410 -- 66,366,673(+) AGCTC(A/G)GCATG intron-variant
rs1566871 -- 66,366,781(+) cccat(C/T)tctac intron-variant
rs1815807 -- 66,365,634(+) CCCAA(A/G)AACTA intron-variant, downstream-variant-500B
rs2279861 -- 66,365,865(+) CCTCC(A/G)TGCTC intron-variant, downstream-variant-500B
rs2279862 -- 66,367,708(+) AGGGC(C/T)TCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC29A2 Gene

Variant ID Type Subtype PubMed ID
dgv1187n71 CNV Loss 21882294
nsv897772 CNV Loss 21882294
nsv832193 CNV Loss 17160897

Relevant External Links for SLC29A2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC29A2 Gene

Disorders for SLC29A2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SLC29A2 Gene in MalaCards »

(2) Diseases for SLC29A2 Gene including...

(3) Novoseek inferred disease relationships for SLC29A2 Gene

Disease -log(P) Hits PubMed IDs
leukemia lymphocytic chronic 30 1
leukemia 29.9 5
hyperglycemia 10.5 1

Relevant External Links for SLC29A2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLC29A2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for SLC29A2 Gene

Publications for SLC29A2 Gene

  1. Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line. (PMID: 9478986) Crawford C.R. … Belt J.A. (J. Biol. Chem. 1998) 2 3 4 23
  2. Functional analysis of site-directed glycosylation mutants of the human equilibrative nucleoside transporter-2. (PMID: 12590919) Ward J.L. … Tse C.-M. (Arch. Biochem. Biophys. 2003) 3 4 23
  3. A mammalian delayed-early response gene encodes HNP36, a novel, conserved nucleolar protein. (PMID: 7639753) Williams J.B. … Lanahan A.A. (Biochem. Biophys. Res. Commun. 1995) 3 4 23
  4. Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2. (PMID: 16214850) Owen R.P. … Giacomini K.M. (Drug Metab. Dispos. 2006) 3 4 23
  5. The human HNP36 gene is localized to chromosome 11q13 and produces alternative transcripts that are not mutated in multiple endocrine neoplasia, type 1 (MEN I) syndrome. (PMID: 9192854) Williams J.B. … Gerhard D.S. (Genomics 1997) 2 3

Products for SLC29A2 Gene

Sources for SLC29A2 Gene

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