Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC29A2 Gene

Aliases for SLC29A2 Gene

  • Solute Carrier Family 29 Member 2 2 3 4
  • Solute Carrier Family 29 (Equilibrative Nucleoside Transporter), Member 2 2 3 5
  • Equilibrative Nitrobenzylmercaptopurine Riboside-Insensitive Nucleoside Transporter 3 4
  • Equilibrative NBMPR-Insensitive Nucleoside Transporter 3 4
  • Hydrophobic Nucleolar Protein, 36 KDa 3 4
  • Delayed-Early Response Protein 12 3 4
  • Nucleoside Transporter, Ei-Type 3 4
  • 36 KDa Nucleolar Protein HNP36 3 4
  • HNP36 3 4
  • DER12 3 4
  • ENT2 3 4
  • Solute Carrier Family 29 (Nucleoside Transporters), Member 2 3
  • Hydrophobic Nucleolar Protein, 36kD 3

External Ids for SLC29A2 Gene

Previous HGNC Symbols for SLC29A2 Gene

  • ENT2
  • HNP36

Previous GeneCards Identifiers for SLC29A2 Gene

  • GC11M068664
  • GC11M067811
  • GC11M066379
  • GC11M065905
  • GC11M065886
  • GC11M066129
  • GC11M062455

Summaries for SLC29A2 Gene

Entrez Gene Summary for SLC29A2 Gene

  • The uptake of nucleosides by transporters, such as SLC29A2, is essential for nucleotide synthesis by salvage pathways in cells that lack de novo biosynthetic pathways. Nucleoside transport also plays a key role in the regulation of many physiologic processes through its effect on adenosine concentration at the cell surface (Griffiths et al., 1997 [PubMed 9396714]).[supplied by OMIM, Nov 2008]

GeneCards Summary for SLC29A2 Gene

SLC29A2 (Solute Carrier Family 29 Member 2) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and One carbon pool by folate. GO annotations related to this gene include nucleoside transmembrane transporter activity. An important paralog of this gene is SLC29A3.

UniProtKB/Swiss-Prot for SLC29A2 Gene

  • Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine.

Tocris Summary for SLC29A2 Gene

  • Nucleoside transporters are divided into two families: the Na+-dependent solute carrier family 28 (SLC28) and the equilibrative solute carrier family 29 (SLC29). SLC28 family transporters (CNT1, 2 and 3) display subtype-selective tissue expression patterns.

Gene Wiki entry for SLC29A2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC29A2 Gene

Genomics for SLC29A2 Gene

Regulatory Elements for SLC29A2 Gene

Promoters for SLC29A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC29A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC29A2 Gene

Chromosome:
11
Start:
66,362,521 bp from pter
End:
66,372,476 bp from pter
Size:
9,956 bases
Orientation:
Minus strand

Genomic View for SLC29A2 Gene

Genes around SLC29A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC29A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC29A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC29A2 Gene

Proteins for SLC29A2 Gene

  • Protein details for SLC29A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14542-S29A2_HUMAN
    Recommended name:
    Equilibrative nucleoside transporter 2
    Protein Accession:
    Q14542
    Secondary Accessions:
    • B3KPY7
    • O43530
    • Q52M84
    • Q96R00
    • Q9UPE0

    Protein attributes for SLC29A2 Gene

    Size:
    456 amino acids
    Molecular mass:
    50113 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA60380.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC29A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC29A2 Gene

Proteomics data for SLC29A2 Gene at MOPED

Post-translational modifications for SLC29A2 Gene

  • Glycosylation at Asn 48, Asn 57, and Asn 225
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SLC29A2 Gene

Domains & Families for SLC29A2 Gene

Gene Families for SLC29A2 Gene

Suggested Antigen Peptide Sequences for SLC29A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14542

UniProtKB/Swiss-Prot:

S29A2_HUMAN :
  • Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
Family:
  • Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
genes like me logo Genes that share domains with SLC29A2: view

Function for SLC29A2 Gene

Molecular function for SLC29A2 Gene

GENATLAS Biochemistry:
solute carrier family 29,member A2,equilibrative nucleoside transporter,growth factor responsive,delayed early response gene of unknown function,expressed in pituitary and parathyroid glands,not mutated in MEN1
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.2 mM for uridine {ECO:0000269 PubMed:12527552, ECO:0000269 PubMed:9396714}; KM=0.75 mM for adenosine {ECO:0000269 PubMed:12527552, ECO:0000269 PubMed:9396714}; Note=Vmax for adenosine uptake is about the same for SLC29A1 and SLC29A2.;
UniProtKB/Swiss-Prot Function:
Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine.
UniProtKB/Swiss-Prot Induction:
By PDGF/platelet derived growth factor and fibroblast growth factor (FGF).
genes like me logo Genes that share phenotypes with SLC29A2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC29A2

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC29A2 Gene

Localization for SLC29A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC29A2 Gene

Basolateral cell membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein. Note=Localized at the basolateral cell membrane in polarized MDCK cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC29A2 Gene COMPARTMENTS Subcellular localization image for SLC29A2 gene
Compartment Confidence
nucleus 5
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for SLC29A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus TAS 7639753
genes like me logo Genes that share ontologies with SLC29A2: view

Pathways & Interactions for SLC29A2 Gene

genes like me logo Genes that share pathways with SLC29A2: view

Interacting Proteins for SLC29A2 Gene

Gene Ontology (GO) - Biological Process for SLC29A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 9396714
GO:0006810 transport IEA --
GO:0015858 nucleoside transport IDA 12527552
genes like me logo Genes that share ontologies with SLC29A2: view

No data available for SIGNOR curated interactions for SLC29A2 Gene

Drugs & Compounds for SLC29A2 Gene

(16) Drugs for SLC29A2 Gene - From: Novoseek, HMDB, Tocris, DrugBank, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Target 1839
Dipyridamole Approved Pharma Inhibition, Inhibitor Adenosine transport inhibitor 76
Didanosine Approved Pharma Transporter 150
Gemcitabine Approved Pharma Transporter Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1881
Mercaptopurine Approved Pharma Transporter, substrate 0

(7) Additional Compounds for SLC29A2 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>14</sup>C]adenosine
Dilazep dihydrochloride
20153-98-4
NBMPR
38048-32-7

(5) Tocris Compounds for SLC29A2 Gene

Compound Action Cas Number
5-Iodotubercidin Potent adenosine kinase inhibitor; also inhibits nucleoside transporters and a range of other kinases 24386-93-4
Cilostazol PDE3A inhibitor. Also adenosine uptake inhibitor 73963-72-1
Dilazep dihydrochloride Adenosine uptake inhibitor 20153-98-4
Dipyridamole Adenosine transport inhibitor 58-32-2
NBMPR Equilibrative nucleoside transporter 1 (ENT1) inhibitor 38048-32-7
genes like me logo Genes that share compounds with SLC29A2: view

Transcripts for SLC29A2 Gene

Unigene Clusters for SLC29A2 Gene

Solute carrier family 29 (nucleoside transporters), member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC29A2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e · 3f · 3g · 3h ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - - - -
SP9: - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - -
SP12: - - -
SP13: - - - - -
SP14: - -
SP15: -
SP16:
SP17: -
SP18:

ExUns: 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17
SP1: - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - -
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - - - - - -

Relevant External Links for SLC29A2 Gene

GeneLoc Exon Structure for
SLC29A2
ECgene alternative splicing isoforms for
SLC29A2

Expression for SLC29A2 Gene

mRNA expression in normal human tissues for SLC29A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC29A2 Gene

This gene is overexpressed in Muscle - Skeletal (x12.7).

Protein differential expression in normal tissues from HIPED for SLC29A2 Gene

This gene is overexpressed in Fetal Liver (36.3) and Retina (32.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC29A2 Gene



SOURCE GeneReport for Unigene cluster for SLC29A2 Gene Hs.569017

mRNA Expression by UniProt/SwissProt for SLC29A2 Gene

Q14542-S29A2_HUMAN
Tissue specificity: Expressed in skeletal muscle, liver, lung, placenta, brain, heart, kidney and ovarian tissues.
genes like me logo Genes that share expression patterns with SLC29A2: view

Protein tissue co-expression partners for SLC29A2 Gene

Primer Products

In Situ Assay Products

Orthologs for SLC29A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC29A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC29A2 35
  • 90.18 (n)
  • 90.11 (a)
SLC29A2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC29A2 35
  • 90.11 (n)
  • 91.43 (a)
SLC29A2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc29a2 35
  • 87.42 (n)
  • 89.62 (a)
Slc29a2 16
Slc29a2 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC29A2 35
  • 99.05 (n)
  • 99.12 (a)
SLC29A2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC29A2 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC29A2 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc29a2 35
  • 63.03 (n)
  • 62.14 (a)
zebrafish
(Danio rerio)
Actinopterygii slc29a2 35
  • 57.11 (n)
  • 55.24 (a)
zgc63618 35
slc29a2 36
  • 50 (a)
OneToMany
SLC29A2 (2 of 2) 36
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta BEST:LD04971 37
  • 29 (a)
Ent1 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ent-3 36
  • 15 (a)
ManyToMany
ent-4 36
  • 23 (a)
ManyToMany
ent-5 36
  • 23 (a)
ManyToMany
ent-6 36
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for SLC29A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC29A2 Gene

ENSEMBL:
Gene Tree for SLC29A2 (if available)
TreeFam:
Gene Tree for SLC29A2 (if available)

Paralogs for SLC29A2 Gene

Paralogs for SLC29A2 Gene

(2) SIMAP similar genes for SLC29A2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC29A2: view

Variants for SLC29A2 Gene

Sequence variations from dbSNP and Humsavar for SLC29A2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs8187643 - 66,371,579(-) GAGGA(G/T)ACGCC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs8187644 - 66,369,440(-) TTCAA(A/C)MATTG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs8187648 - 66,369,194(-) CGTCC(C/T)GGAGA intron-variant, nc-transcript-variant, reference, missense
rs1344410 -- 66,366,673(+) AGCTC(A/G)GCATG intron-variant, downstream-variant-500B
rs1566871 -- 66,366,781(+) cccat(C/T)tctac intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SLC29A2 Gene

Variant ID Type Subtype PubMed ID
dgv1187n71 CNV Loss 21882294
nsv897772 CNV Loss 21882294
nsv832193 CNV Loss 17160897

Variation tolerance for SLC29A2 Gene

Residual Variation Intolerance Score: 36.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC29A2 Gene

HapMap Linkage Disequilibrium report
SLC29A2
Human Gene Mutation Database (HGMD)
SLC29A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC29A2 Gene

Disorders for SLC29A2 Gene

Relevant External Links for SLC29A2

Genetic Association Database (GAD)
SLC29A2
Human Genome Epidemiology (HuGE) Navigator
SLC29A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC29A2

No disorders were found for SLC29A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC29A2 Gene

Publications for SLC29A2 Gene

  1. Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line. (PMID: 9478986) Crawford C.R. … Belt J.A. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. Ethanol blocks adenosine uptake via inhibiting the nucleoside transport system in bronchial epithelial cells. (PMID: 19298329) Allen-Gipson D.S. … Wyatt T.A. (Alcohol. Clin. Exp. Res. 2009) 23 25 26
  3. Hypoxia-inducible factor-dependent repression of equilibrative nucleoside transporter 2 attenuates mucosal inflammation during intestinal hypoxia. (PMID: 19105964) Morote-Garcia J.C. … Eltzschig H.K. (Gastroenterology 2009) 3 23
  4. Insulin restores glucose inhibition of adenosine transport by increasing the expression and activity of the equilibrative nucleoside transporter 2 in human umbilical vein endothelium. (PMID: 16924660) MuA+oz G. … Sobrevia L. (J. Cell. Physiol. 2006) 3 23
  5. Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2. (PMID: 16214850) Owen R.P. … Giacomini K.M. (Drug Metab. Dispos. 2006) 3 23

Products for SLC29A2 Gene

Sources for SLC29A2 Gene

Back to Top

Content