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GIFtS

SLC29A2 Gene

protein-coding   GIFtS: 56
GCID: GC11M066129

solute carrier family 29 (nucleoside transporters), member...


(Previous symbols: ENT2, HNP36)
 Explore 14 diseases affiliated with
SLC29A2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC29A2    

Aliases
for SLC29A2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 29 (Nucleoside Transporters), Member 21 2     Hydrophobic Nucleolar Protein, 36 KDa2 3
DER121 2 3 5     Nucleoside Transporter, Ei-Type2 3
HNP361 2 3 5     Solute Carrier Family 29 Member 22 3
ENT21 2 3     36 KDa Nucleolar Protein HNP362 3
Delayed-Early Response Protein 122 3     Equilibrative Nucleoside Transporter 22
Equilibrative NBMPR-Insensitive Nucleoside Transporter2 3     Hydrophobic Nucleolar Protein, 36kD2
Equilibrative Nitrobenzylmercaptopurine Riboside-Insensitive Nucleoside
Transporter2 3
     

External Ids:    HGNC: 110041   Entrez Gene: 31772   Ensembl: ENSG000001746697   OMIM: 6021105   UniProtKB: Q145423   

Export aliases for SLC29A2 gene to outside databases

Previous GC identifers: GC11M068664 GC11M067811 GC11M066379 GC11M065905 GC11M065886 GC11M062455


Summaries
for SLC29A2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC29A2:
The uptake of nucleosides by transporters, such as SLC29A2, is essential for nucleotide synthesis by salvage pathways
in cells that lack de novo biosynthetic pathways. Nucleoside transport also plays a key role in the regulation of many
physiologic processes through its effect on adenosine concentration at the cell surface (Griffiths et al., 1997
(PubMed 9396714)).(supplied by OMIM, Nov 2008)

UniProtKB/Swiss-Prot: S29A2_HUMAN, Q14542
Function: Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very
less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine

summary for SLC29A2:
Nucleoside transporters are divided into two families; the Na+-dependent solute carrier family 28 (SLC28)
and the equilibrative solute carrier family 29 (SLC29). SLC28 family transporters (CNT1-3) display
subtype-selective expression patterns; CNT1 is localized primarily to epithelial tissue whereas CNT2 and
CNT3 have more widespread distributions. SLC29 family transporters (ENT1-4) are glycosylated proteins,
localized to the plasma and mitochondrial membranes. They are expressed in the heart, brain, mammary gland,
erythrocytes and placenta, and also in fetal liver and spleen. They mediate nucleoside influx and efflux and
exhibit highest affinity for adenosine. CNT and ENT transporters play critical roles in nucleoside salvage
pathways where they mediate the first step of nucleotide biosynthesis. In addition, these transporters work
in concert to terminate adenosine signaling and are vital determinants in the response to a variety of
anticancer and antiviral treatments, as they modulate the entry of these nucleoside analogs into target
tissues.

Gene Wiki entry for SLC29A2 (Equilibrative nucleoside transporter 2)


Genomic Views
for SLC29A2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC29A2 gene promoter:
         STAT1   ATF-2   ARP-1   STAT1beta   c-Jun   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC29A2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC29A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC29A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13

SLC29A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC29A2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M066129:  view genomic region     (about GC identifiers)

Start:
 66,129,992 bp from pter      End:
 66,139,685 bp from pter
Size:
 9,694 bases      Orientation:
 minus strand

Proteins
for SLC29A2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: S29A2_HUMAN, Q14542 (See protein sequence)
Recommended Name: Equilibrative nucleoside transporter 2  
Size: 456 amino acids; 50113 Da
Subcellular location: Basolateral cell membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane
protein. Note=Localized at the basolateral cell membrane in polarized MDCK cells
Sequence caution: Sequence=CAA60380.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: B3KPY7 O43530 Q52M84 Q96R00 Q9UPE0
Alternative splicing: 3 isoforms:  Q14542-1   Q14542-2   Q14542-3   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for SLC29A2: NX_Q14542

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14542

    • SLC29A2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001523.2  
    ENSEMBL proteins: 
     ENSP00000311250   ENSP00000350024   ENSP00000444870   ENSP00000439456   ENSP00000442116  
     ENSP00000440329  
    Reactome Protein details: Q14542
    Human Recombinant Protein Products: 
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    Novus Biologicals SLC29A2 Protein
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC29A2

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus TAS7639753
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7639753
    GO:0016021integral to membrane ----
    GO:0016323basolateral plasma membrane IDA12527552


    SLC29A2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLC29A2

    Protein Domains /
    Families
    for SLC29A2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC29A2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002259 Eqnu_transpt

    Graphical View of Domain Structure for InterPro Entry Q14542

    ProtoNet protein and cluster: Q14542

    1 Blocks protein family: IPB002259 Delayed-early response protein/equilibrative nucleoside transporter signature

    UniProtKB/Swiss-Prot: S29A2_HUMAN, Q14542
    Similarity: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family


    Function
    for SLC29A2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: S29A2_HUMAN, Q14542
    Function: Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very
    less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine
    Biophysicochemical properties: Kinetic parameters: KM=0.2 mM for uridine; KM=0.75 mM for adenosine; Note=Vmax for
    adenosine uptake is about the same for SLC29A1 and SLC29A2;
    Induction: By PDGF/platelet derived growth factor and fibroblast growth factor (FGF)

         Genatlas biochemistry entry for SLC29A2:
    solute carrier family 29,member A2,equilibrative nucleoside transporter,growth factor responsive,delayed early response
    gene of unknown function,expressed in pituitary and parathyroid glands,not mutated in MEN1

    miRNA
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    hsa-miR-3607-3p hsa-miR-20a hsa-miR-519d hsa-miR-3065-3p hsa-miR-106a hsa-miR-106b hsa-miR-200a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: SLC29A2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005337nucleoside transmembrane transporter activity IEA--


    SLC29A2 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI phenotypic allele for Slc29a2 (no phenotypes)

    SLC29A2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLC29A2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transmembrane transport of small molecules0.50
    2Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
    		Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane1.00
    3Antimetabolite Pathway - Folate Cycle, Pharmacodynamics
    		Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics0.36
    4Transport of organic anions
    		Transport of vitamins, nucleosides, and related molecules0.35

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for SLC29A2
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
    Transport of vitamins, nucleosides, and related molecules

    1 PharmGKB Pathway for SLC29A2
        Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics


    SLC29A2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC29A2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for SLC29A2 (Q145423 ENSP000003500244) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438893I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process TAS9396714
    GO:0007595lactation ----
    GO:0008283cell proliferation TAS7639753
    GO:0015853adenine transport ----
    GO:0015854guanine transport ----


    SLC29A2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC29A2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC29A2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SLC29A2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DipyridamoleAdenosine transport inhibitor[58-32-2]
    CilostazolPDE3A inhibitor. Also adenosine uptake inhibitor[73963-72-1]
    Dilazep dihydrochlorideAdenosine uptake inhibitor[35898-87-4]

    2 HMDB Compounds for SLC29A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenine1,6-Dihydro-6-iminopurine (see all 19)73-24-5--
    Hypoxanthine1,7-Dihydro-6H-purin-6-one (see all 20)68-94-0--
    10 Novoseek chemical compound relationships for SLC29A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nitrobenzylthioinosine 91.4 2 11085929 (1), 10366666 (1)
    nucleoside 87.2 67 19487253 (2), 16214850 (2), 16530731 (2), 10366666 (2) (see all 34)
    dipyridamole 75.2 4 15644498 (1), 10366666 (1), 17636949 (1)
    uridine 70.3 3 12440703 (1), 9478986 (1)
    cytidine 53.2 1 12440703 (1)
    purine 51.7 2 17473446 (1)
    hypoxanthine 49.6 1 10722669 (1)
    inosine 45 1 10722669 (1)
    fludarabine 40.9 2 15510196 (1), 15454483 (1)
    glucose 0 1 16924660 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC29A2 / S29A2 

    Transcripts
    for SLC29A2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC29A2 gene: 
    NM_001532.2  

    Unigene Cluster for SLC29A2:

    Solute carrier family 29 (nucleoside transporters), member 2
    Hs.569017  [show with all ESTs]
    Unigene Representative Sequence: AK092328
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311161 ENST00000357440(uc001oht.3) ENST00000540386 ENST00000544554(uc009yrf.3 uc001ohu.3 uc001ohv.3)
    ENST00000541567 ENST00000546034

    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC29A2 (see all 15):
    hsa-miR-3607-3p hsa-miR-20a hsa-miR-519d hsa-miR-3065-3p hsa-miR-106a hsa-miR-106b hsa-miR-200a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: SLC29A2 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF029358.1 AF034102.1 AF401235.1 AK057041.1 AK057987.1 AK092328.1 BC011387.1 BC093634.1 
    BC143335.1 X86681.1 

    16 DOTS entries:

    DT.95160962  DT.95160959  DT.100793793  DT.95160961  DT.120734067  DT.40196964  DT.100793791  DT.40273803 
    DT.99990259  DT.100735508  DT.86856348  DT.120734109  DT.97803296  DT.102826960  DT.120734125  DT.120734141 

    24/110 AceView cDNA sequences (see all 110):

    BE302173 AU133242 AI263032 AU132274 CA433513 BG469467 BQ689455 BM762894 
    CR621298 BU191087 AU149796 AA081530 AI989929 BM980528 NM_001532 BQ437617 
    BQ688477 BX398760 CB243770 CB150549 AW079391 AF034102 AK057987 AI520689 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for SLC29A2 (see all 18)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e · 3f · 3g · 3h ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^
    SP1:                                -     -     -     -     -     -     -                 -                       -                 -     -           -         
    SP2:                                -     -     -     -     -     -     -     -           -                       -                 -     -           -         
    SP3:                                                                                      -                       -                 -     -           -         
    SP4:                                                                                      -                       -                 -     -           -         
    SP5:                                                                                      -                       -     -           -     -           -         

    ExUns: 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17
    SP1:              -                                         -               
    SP2:              -     -                                   -               
    SP3:              -                                         -               
    SP4:              -           -                             -               
    SP5:              -                                         -               


    ECgene alternative splicing isoforms for SLC29A2

    Expression
    for SLC29A2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC29A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SLC29A2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC29A2

    SOURCE GeneReport for Unigene cluster: Hs.569017

    UniProtKB/Swiss-Prot: S29A2_HUMAN, Q14542
    Tissue specificity: Expressed in skeletal muscle, liver, lung, placenta, brain, heart, kidney and ovarian tissues

        SABiosciences Expression via Pathway-Focused PCR Array including SLC29A2: 
              Drug Transporters in human mouse rat

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    Orthologs
    for SLC29A2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SLC29A2 gene from 4/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    African clawed frog
    (Xenopus laevis)    		 Amphibia CF286408.12   -- 73.49(n)    CF286408.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc636182 similar to solute carrier family 29, member 2 74.27(n)   394022  BC055167.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta BEST:LD049713 equilibrative nucleoside transporter,
    nitrobenzyl-thioinosine-insensitive    		 29(a)   26E3   --
    worm
    (Caenorhabditis elegans)    		 Secernentea CELE_F44D12.91 Protein F44D12.9 41.17(n)
    31.85(a)    		   177862  NM_069406.6  NP_501807.3 


    ENSEMBL Gene Tree for SLC29A2 (if available)
    TreeFam Gene Tree for SLC29A2 (if available) 

    Paralogs
    for SLC29A2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC29A2 gene
    SLC29A42  SLC29A32  SLC29A12  
    2 SIMAP similar genes for SLC29A2 using alignment to 2 protein entries:     S29A2_HUMAN (see all proteins):
    SLC29A1    SLC29A3

    SLC29A2 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC29A2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/215 NCBI SNPs in SLC29A2 are shown (see all 215)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1409579891,2
    		--66129714(+) GAGGAC/TGCTGG 1 -- int10--------
    rs756054651,2
    		C,--66129875(+) CCCCTC/TTCAGG 1 -- int12Minor allele frequency- T:0.03WA 120
    rs1835472441,2
    		--66130077(+) CTGCCC/TCAAAC 1 -- ut310--------
    rs1884815601,2
    		--66130170(+) TACCAC/TGGACC 1 -- ut310--------
    rs1497929411,2
    		--66130221(+) GGGGGA/CAGCAC 1 -- ut310--------
    rs1457801801,2
    		--66130297(+) CTTTGC/TAAACT 1 -- ut310--------
    rs1161830861,2
    		F,--66130352(+) CCAGGC/TCCAGC 1 -- ut311Minor allele frequency- T:0.02WA 118
    rs31775141,2
    		C,F,--66130358(-) AGCCCC/AGCTGG 1 -- ut31 ese312Minor allele frequency- A:0.40MN NA CSA WA EA 558
    rs1928779861,2
    		--66130367(+) CTCTGC/TGGAGT 1 -- ut310--------
    rs1168642521,2
    		F,--66130477(+) CACAAC/TTTCCC 1 -- ut311Minor allele frequency- T:0.02NA 120

    HapMap Linkage Disequilibrium report for SLC29A2 (66129992 - 66139685 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLC29A2: --
    Human Gene Mutation Database (HGMD): SLC29A2

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    Disorders / Diseases
    for SLC29A2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC29A2 for disorders           About GeneDecksing

    OMIM gene information: 602110    OMIM disorders: --

    14 diseases for SLC29A2:    About MalaCards
    pre-eclampsia    multiple endocrine neoplasia    inflammatory bowel disease    chronic lymphocytic leukemia
    acute myeloid leukemia    lymphocytic leukemia    myeloid leukemia    eclampsia
    hyperglycemia    leukemia    choriocarcinoma    t-cell leukemia
    hypoxia    carcinoma

    3 Novoseek disease relationships for SLC29A2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia lymphocytic chronic 30 1 15510196 (1)
    leukemia 29.9 5 16530731 (3), 15571274 (1), 18279955 (1)
    hyperglycemia 10.5 1 16085043 (1)

    Human Genome Epidemiology (HuGE) Navigator: SLC29A2 (1 document)

    Export disorders for SLC29A2 gene to outside databases

    Publications
    for SLC29A2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC29A2 gene, integrated from 9 sources (see all 67):
    (articles sorted by number of sources associating them with SLC29A2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line. (PubMed id 9478986)1, 2, 3, 9 Crawford C.R.... Belt J.A. (1998)
    2. Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2. (PubMed id 16214850)1, 2, 9 Owen R.P.... Giacomini K.M. (2006)
    3. A mammalian delayed-early response gene encodes HNP36, a novel, conserved nucleolar protein. (PubMed id 7639753)1, 2, 9 Williams J.B. and Lanahan A.A. (1995)
    4. Functional analysis of site-directed glycosylation mutants of the human equilibrative nucleoside transporter-2. (PubMed id 12590919)1, 2, 9 Ward J.L.... Tse C.-M. (2003)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells. (PubMed id 12527552)1, 2 Mangravite L.M.... Giacomini K.M. (2003)
    8. The human HNP36 gene is localized to chromosome 11q13 and produces alternative transcripts that are not mutated in multiple endocrine neoplasia, type 1 (MEN I) syndrome. (PubMed id 9192854)1, 3 Williams J.B....Gerhard D.S. (1997)
    9. Molecular cloning and characterization of a nitrobenzylthioinosine- insensitive (ei) equilibrative nucleoside transporter from human placenta. (PubMed id 9396714)1, 2 Griffiths M.... Baldwin S.A. (1997)
    10. Hypoxia-inducible factor-dependent repression of equilibrative nucleoside transporter 2 attenuates mucosal inflammation during intestinal hypoxia. (PubMed id 19105964)1, 9 Morote-Garcia J.C....Eltzschig H.K. (2009)

    External Searches for SLC29A2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SLC29A2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3177 HGNC: 11004 AceView: SLC29A2 Ensembl:ENSG00000174669 euGenes: HUgn3177
    ECgene: SLC29A2 H-InvDB: SLC29A2

    Other Databases showing SLC29A2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC29A2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC29A2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC29A2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC29A2 gene:
    Search GeneIP for patents involving SLC29A2

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