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SLC29A2 Gene

protein-coding   GIFtS: 61
GCID: GC11M066129

Solute Carrier Family 29 (Equilibrative Nucleoside Transporter),...

(Previous names: solute carrier family 29 (nucleoside transporters), member...)
(Previous symbols: ENT2, HNP36)
  See SLC29A2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 29 (Equilibrative Nucleoside Transporter), Member
21 2
     Equilibrative Nitrobenzylmercaptopurine Riboside-Insensitive Nucleoside
Transporter2 3
HNP361 2 3 5     Hydrophobic Nucleolar Protein, 36 KDa2 3
ENT21 2 3     Nucleoside Transporter, Ei-Type2 3
DER122 3 5     Solute Carrier Family 29 Member 22 3
Solute Carrier Family 29 (Nucleoside Transporters), Member 21 2     36 KDa Nucleolar Protein HNP362 3
Delayed-Early Response Protein 122 3     Equilibrative Nucleoside Transporter 22
Equilibrative NBMPR-Insensitive Nucleoside Transporter2 3     Hydrophobic Nucleolar Protein, 36kD2

External Ids:    HGNC: 110041   Entrez Gene: 31772   Ensembl: ENSG000001746697   OMIM: 6021105   UniProtKB: Q145423   

Export aliases for SLC29A2 gene to outside databases

Previous GC identifers: GC11M068664 GC11M067811 GC11M066379 GC11M065905 GC11M065886 GC11M062455


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC29A2 Gene:
The uptake of nucleosides by transporters, such as SLC29A2, is essential for nucleotide synthesis by salvage
pathways in cells that lack de novo biosynthetic pathways. Nucleoside transport also plays a key role in the
regulation of many physiologic processes through its effect on adenosine concentration at the cell surface
(Griffiths et al., 1997 (PubMed 9396714)).(supplied by OMIM, Nov 2008)

GeneCards Summary for SLC29A2 Gene:
SLC29A2 (solute carrier family 29 (equilibrative nucleoside transporter), member 2) is a protein-coding gene. Diseases associated with SLC29A2 include hyperglycemia, and b-cell chronic lymphocytic leukemia. GO annotations related to this gene include nucleoside transmembrane transporter activity. An important paralog of this gene is SLC29A4.

UniProtKB/Swiss-Prot: S29A2_HUMAN, Q14542
Function: Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine.
Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and
draflazine

summary for SLC29A2 Gene:
Nucleoside transporters are divided into two families; the Na+-dependent solute carrier family 28 (SLC28)
and the equilibrative solute carrier family 29 (SLC29). SLC28 family transporters (CNT1-3) display
subtype-selective expression patterns; CNT1 is localized primarily to epithelial tissue whereas CNT2 and
CNT3 have more widespread distributions. SLC29 family transporters (ENT1-4) are glycosylated proteins,
localized to the plasma and mitochondrial membranes. They are expressed in the heart, brain, mammary gland,
erythrocytes and placenta, and also in fetal liver and spleen. They mediate nucleoside influx and efflux and
exhibit highest affinity for adenosine. CNT and ENT transporters play critical roles in nucleoside salvage
pathways where they mediate the first step of nucleotide biosynthesis. In addition, these transporters work
in concert to terminate adenosine signaling and are vital determinants in the response to a variety of
anticancer and antiviral treatments, as they modulate the entry of these nucleoside analogs into target
tissues.

Gene Wiki entry for SLC29A2 (Equilibrative nucleoside transporter 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC29A2 gene promoter:
         STAT1   ATF-2   ARP-1   STAT1beta   c-Jun   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC29A2 promoter sequence
   Search Chromatin IP Primers for SLC29A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC29A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13

SLC29A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC29A2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M066129:  view genomic region     (about GC identifiers)

Start:
66,129,992 bp from pter      End:
66,139,685 bp from pter
Size:
9,694 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S29A2_HUMAN, Q14542 (See protein sequence)
Recommended Name: Equilibrative nucleoside transporter 2  
Size: 456 amino acids; 50113 Da
Sequence caution: Sequence=CAA60380.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: B3KPY7 O43530 Q52M84 Q96R00 Q9UPE0
Alternative splicing: 3 isoforms:  Q14542-1   Q14542-2   Q14542-3   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for SLC29A2: NX_Q14542

Explore proteomics data for SLC29A2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn48, Asn57, Asn225
  • Modification sites at PhosphoSitePlus

  • See SLC29A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001523.2  
    ENSEMBL proteins: 
     ENSP00000311250   ENSP00000350024   ENSP00000444870   ENSP00000439456   ENSP00000442116  
     ENSP00000440329  
    Reactome Protein details: Q14542

    SLC29A2 Human Recombinant Protein Products:

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    Novus Biologicals SLC29A2 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SLC29A2 

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    LSBio Antibodies in human, mouse, rat for SLC29A2

    SLC29A2 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for SLC29A2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Equilibrative nucleoside transporter 2
    SLC29 family

    2 InterPro protein domains:
     IPR002259 Eqnu_transpt
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q14542

    ProtoNet protein and cluster: Q14542

    1 Blocks protein domain: IPB002259 Delayed-early response protein/equilibrative nucleoside transporter signature

    UniProtKB/Swiss-Prot: S29A2_HUMAN, Q14542
    Similarity: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family


    Find genes that share domains with SLC29A2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S29A2_HUMAN, Q14542
    Function: Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine.
    Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and
    draflazine
    Biophysicochemical properties: Kinetic parameters: KM=0.2 mM for uridine; KM=0.75 mM for adenosine; Note=Vmax for
    adenosine uptake is about the same for SLC29A1 and SLC29A2;
    Induction: By PDGF/platelet derived growth factor and fibroblast growth factor (FGF)

         Genatlas biochemistry entry for SLC29A2:
    solute carrier family 29,member A2,equilibrative nucleoside transporter,growth factor responsive,delayed early
    response gene of unknown function,expressed in pituitary and parathyroid glands,not mutated in MEN1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005337nucleoside transmembrane transporter activity IEA--
         
    Find genes that share ontologies with SLC29A2           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Slc29a2 (no phenotypes)

    Find genes that share phenotypes with SLC29A2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC29A2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC29A2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC29A2

    miRNA
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    miRTarBase miRNAs that target SLC29A2:
    hsa-mir-93-5p (MIRT048863)

    Block miRNA regulation of human, mouse, rat SLC29A2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC29A2 (see all 15):
    hsa-miR-3607-3p hsa-miR-20a hsa-miR-519d hsa-miR-3065-3p hsa-miR-106a hsa-miR-106b hsa-miR-200a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidSLC29A2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SLC29A2 (NM_001532)
    Sino Biological Human cDNA Clone for SLC29A2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC29A2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC29A2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S29A2_HUMAN, Q14542: Basolateral cell membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass
    membrane protein. Note=Localized at the basolateral cell membrane in polarized MDCK cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    extracellular2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus TAS7639753
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7639753
    GO:0016021integral component of membrane ----
    GO:0016323basolateral plasma membrane IDA12527552

    Find genes that share ontologies with SLC29A2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC29A2 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transmembrane transport of small molecules0.47
    2Transport of vitamins, nucleosides, and related molecules
    Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane0.00
    Transport of vitamins, nucleosides, and related molecules
    3One carbon pool by folate
    Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics0.34


    Find genes that share SuperPaths with SLC29A2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for SLC29A2
        Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

    1 PharmGKB Pathway for SLC29A2
        Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC29A2: 
              Drug Transporters in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SLC29A2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for SLC29A2 (Q145423 ENSP000003500244) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438893I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    ABHD11ENSP000002228004STRING: ENSP00000222800
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process TAS9396714
    GO:0006810transport ----
    GO:0008283cell proliferation TAS7639753
    GO:0015858nucleoside transport IDA12527552
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with SLC29A2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for SLC29A2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DipyridamoleAdenosine transport inhibitor[58-32-2]
    NBMPREquilibrative nucleoside transporter 1 (ENT1) inhibitor[38048-32-7]
    Dilazep dihydrochlorideAdenosine uptake inhibitor[20153-98-4]
    Decynium 22PMAT inhibitor[977-96-8]

    2 HMDB Compounds for SLC29A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenine1,6-Dihydro-6-iminopurine (see all 19)73-24-5--
    Hypoxanthine1,7-Dihydro-6H-purin-6-one (see all 20)68-94-0--

    1 IUPHAR Ligand for SLC29A2 (Equilibrative nucleoside transporter 2)    About this table
    LigandTypeActionAffinityPubmed IDs
    [14C]adenosine
    NoneNone--

    10 Novoseek inferred chemical compound relationships for SLC29A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nitrobenzylthioinosine 91.4 2 11085929 (1), 10366666 (1)
    nucleoside 87.2 67 19487253 (2), 16214850 (2), 16530731 (2), 10366666 (2) (see all 34)
    dipyridamole 75.2 4 15644498 (1), 10366666 (1), 17636949 (1)
    uridine 70.3 3 12440703 (1), 9478986 (1)
    cytidine 53.2 1 12440703 (1)
    purine 51.7 2 17473446 (1)
    hypoxanthine 49.6 1 10722669 (1)
    inosine 45 1 10722669 (1)
    fludarabine 40.9 2 15510196 (1), 15454483 (1)
    glucose 0 1 16924660 (1)



    Find genes that share compounds with SLC29A2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC29A2 gene: 
    NM_001532.2  

    Unigene Cluster for SLC29A2:

    Solute carrier family 29 (nucleoside transporters), member 2
    Hs.569017  [show with all ESTs]
    Unigene Representative Sequence: AK092328
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311161 ENST00000357440(uc001oht.3) ENST00000540386 ENST00000544554(uc009yrf.3 uc001ohu.3 uc001ohv.3)
    ENST00000541567 ENST00000546034
    miRNA
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    hsa-miR-3607-3p hsa-miR-20a hsa-miR-519d hsa-miR-3065-3p hsa-miR-106a hsa-miR-106b hsa-miR-200a hsa-miR-570
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC29A2
      QuantiFast Probe-based Assays in human, mouse, rat SLC29A2

    Additional mRNA sequence: 

    AF029358.1 AF034102.1 AF401235.1 AK057041.1 AK057987.1 AK092328.1 BC011387.1 BC093634.1 
    BC143335.1 X86681.1 

    16 DOTS entries:

    DT.95160962  DT.95160959  DT.100793793  DT.95160961  DT.120734067  DT.40196964  DT.100793791  DT.40273803 
    DT.99990259  DT.100735508  DT.86856348  DT.120734109  DT.97803296  DT.102826960  DT.120734125  DT.120734141 

    Selected AceView cDNA sequences (see all 110):

    BG469467 BX398760 AU132274 BQ437617 AU133242 CR621298 AU149796 CB243770 
    AI263032 BU191087 AI989929 NM_001532 BM980528 BQ688477 BE302173 BM762894 
    BQ689455 CA433513 AA081530 CB150549 AK057041 AW079391 AK092328 AF034102 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC29A2 (see all 18)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e · 3f · 3g · 3h ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^
    SP1:                                -     -     -     -     -     -     -                 -                       -                 -     -           -         
    SP2:                                -     -     -     -     -     -     -     -           -                       -                 -     -           -         
    SP3:                                                                                      -                       -                 -     -           -         
    SP4:                                                                                      -                       -                 -     -           -         
    SP5:                                                                                      -                       -     -           -     -           -         

    ExUns: 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17
    SP1:              -                                         -               
    SP2:              -     -                                   -               
    SP3:              -                                         -               
    SP4:              -           -                             -               
    SP5:              -                                         -               


    ECgene alternative splicing isoforms for SLC29A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC29A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC29A2 Expression
    About this image


    SLC29A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Heart (Cardiovascular System)
             Outflow Tract
    SLC29A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC29A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.569017

    UniProtKB/Swiss-Prot: S29A2_HUMAN, Q14542
    Tissue specificity: Expressed in skeletal muscle, liver, lung, placenta, brain, heart, kidney and ovarian tissues

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC29A2: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC29A2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc29a21 , 5 solute carrier family 29 (nucleoside transporters), more1, 5 87.42(n)1
    89.62(a)1
      19 (4.23 cM)5
    133401  NM_007854.31  NP_031880.21 
     50240065 
    African clawed frog
    (Xenopus laevis)
    Amphibia CF286408.12   -- 73.49(n)    CF286408.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc636182 similar to solute carrier family 29, member 2 74.27(n)   394022  BC055167.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BEST:LD049713 equilibrative nucleoside transporter,
    nitrobenzyl-thioinosine-insensitive
    29(a)   26E3   --
    worm
    (Caenorhabditis elegans)
    Secernentea ent-66
    ent-56
    (see all 4)
    Protein ENT-5 (ent-5) mRNA, complete cds
    (see all 4)
    23(a)
    23(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    IV(13726930-13732723) WBGene00008123
    X(4647523-4649194) WBGene00017532


    ENSEMBL Gene Tree for SLC29A2 (if available)
    TreeFam Gene Tree for SLC29A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC29A2 gene
    SLC29A42  SLC29A12  SLC29A32  
    2 SIMAP similar genes for SLC29A2 using alignment to 2 protein entries:     S29A2_HUMAN (see all proteins):
    SLC29A1    SLC29A3

    Find genes that share paralogs with SLC29A2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC29A2 (see all 305)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1409579891,2
    --66050167(+) GAGGAC/TGCTGG 1 -- int10--------
    rs756054651,2
    C,F--66050328(+) CCCCTC/TTCAGG 1 -- int12Minor allele frequency- T:0.03WA 120
    rs1835472441,2
    --66050530(+) CTGCCC/TCAAAC 1 -- ut310--------
    rs1884815601,2
    --66050623(+) TACCAC/TGGACC 1 -- ut310--------
    rs1497929411,2
    --66050674(+) GGGGGA/CAGCAC 1 -- ut310--------
    rs1457801801,2
    C--66050750(+) CTTTGC/TAAACT 1 -- ut310--------
    rs1161830861,2
    C,F--66050805(+) CCAGGC/TCCAGC 1 -- ut311Minor allele frequency- T:0.02WA 118
    rs31775141,2
    C,F--66050811(-) AGCCCC/AGCTGG 1 -- ut31 ese312Minor allele frequency- A:0.40MN NA CSA WA EA 558
    rs1928779861,2
    --66050820(+) CTCTGC/TGGAGT 1 -- ut310--------
    rs1168642521,2
    C,F--66050930(+) CACAAC/TTTCCC 1 -- ut311Minor allele frequency- T:0.02NA 120

    HapMap Linkage Disequilibrium report for SLC29A2 (66129992 - 66139685 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SLC29A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897772CNV Loss21882294
    nsv832193CNV Loss17160897
    dgv1187n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): SLC29A2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC29A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC29A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602110    OMIM disorders: --

    2 diseases for SLC29A2:    
    About MalaCards
    hyperglycemia    b-cell chronic lymphocytic leukemia


    Find genes that share disorders with SLC29A2           About GenesLikeMe

    3 Novoseek inferred disease relationships for SLC29A2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia lymphocytic chronic 30 1 15510196 (1)
    leukemia 29.9 5 16530731 (3), 15571274 (1), 18279955 (1)
    hyperglycemia 10.5 1 16085043 (1)

    Genetic Association Database (GAD): SLC29A2
    Human Genome Epidemiology (HuGE) Navigator: SLC29A2 (1 document)

    Export disorders for SLC29A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC29A2 gene, integrated from 10 sources (see all 71):
    (articles sorted by number of sources associating them with SLC29A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line. (PubMed id 9478986)1, 2, 3, 9 Crawford C.R.... Belt J.A. (J. Biol. Chem. 1998)
    2. Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2. (PubMed id 16214850)1, 2, 9 Owen R.P.... Giacomini K.M. (Drug Metab. Dispos. 2006)
    3. A mammalian delayed-early response gene encodes HNP36, a novel, conserved nucleolar protein. (PubMed id 7639753)1, 2, 9 Williams J.B. and Lanahan A.A. (Biochem. Biophys. Res. Commun. 1995)
    4. Functional analysis of site-directed glycosylation mutants of the human equilibrative nucleoside transporter-2. (PubMed id 12590919)1, 2, 9 Ward J.L.... Tse C.-M. (Arch. Biochem. Biophys. 2003)
    5. Contribution of adenosine related genes to the risk of depression with disturbed sleep. (PubMed id 20392501)1, 4 Gass N....Paunio T. (J Affect Disord 2010)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells. (PubMed id 12527552)1, 2 Mangravite L.M.... Giacomini K.M. (Am. J. Physiol. 2003)
    9. The human HNP36 gene is localized to chromosome 11q13 and produces alternative transcripts that are not mutated in multiple endocrine neoplasia, type 1 (MEN I) syndrome. (PubMed id 9192854)1, 3 Williams J.B....Gerhard D.S. (Genomics 1997)
    10. Molecular cloning and characterization of a nitrobenzylthioinosine- insensitive (ei) equilibrative nucleoside transporter from human placenta. (PubMed id 9396714)1, 2 Griffiths M.... Baldwin S.A. (Biochem. J. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3177 HGNC: 11004 AceView: SLC29A2 Ensembl:ENSG00000174669 euGenes: HUgn3177
    ECgene: SLC29A2 H-InvDB: SLC29A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SLC29A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC29A2 gene:
    Search GeneIP for patents involving SLC29A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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