Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SLC28A3 Gene

protein-coding   GIFtS: 52
GCID: GC09M086890

Solute Carrier Family 28 (Concentrative Nucleoside Transporter),...

(Previous names: solute carrier family 28 (sodium-coupled nucleoside transporter),...)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Solute Carrier Family 28 (Concentrative Nucleoside Transporter), Member
31 2
     Concentrative Na+-Nucleoside Cotransporter2
CNT32 3 5     Solute Carrier Family 28 Member 32
Solute Carrier Family 28 (Sodium-Coupled Nucleoside Transporter), Member 31 2     CNT 33
Concentrative Na(+)-Nucleoside Cotransporter 32 3     hCNT33

External Ids:    HGNC: 164841   Entrez Gene: 640782   Ensembl: ENSG000001975067   OMIM: 6082695   UniProtKB: Q9HAS33   

Export aliases for SLC28A3 gene to outside databases

Previous GC identifers: GC09M077936 GC09M078744 GC09M080445 GC09M082350 GC09M084122 GC09M086080 GC09M056719


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SLC28A3 Gene:
Nucleoside transporters, such as SLC28A3, regulate multiple cellular processes, including neurotransmission,
vascular tone, adenosine concentration in the vicinity of cell surface receptors, and transport and metabolism of
nucleoside drugs. SLC28A3 shows broad specificity for pyrimidine and purine nucleosides (Ritzel et al., 2001
(PubMed 11032837)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SLC28A3 Gene:
SLC28A3 (solute carrier family 28 (concentrative nucleoside transporter), member 3) is a protein-coding gene. GO annotations related to this gene include purine-specific nucleoside:sodium symporter activity and nucleoside binding. An important paralog of this gene is SLC28A2.

UniProtKB/Swiss-Prot: S28A3_HUMAN, Q9HAS3
Function: Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous
nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib)
(with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to
transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SLC28A3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC28A3 promoter sequence
   Search Chromatin IP Primers for SLC28A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC28A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.2   Ensembl cytogenetic band:  9q21.33   HGNC cytogenetic band: 9q21.33

SLC28A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC28A3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M086890:  view genomic region     (about GC identifiers)

Start:
86,890,372 bp from pter      End:
86,983,413 bp from pter
Size:
93,042 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: S28A3_HUMAN, Q9HAS3 (See protein sequence)
Recommended Name: Solute carrier family 28 member 3  
Size: 691 amino acids; 76930 Da
Secondary accessions: A8K9Y4 B1AML0 B2RA51 B4E2S8 F5GYE3
Alternative splicing: 2 isoforms:  Q9HAS3-1   Q9HAS3-2   (Exhibits a shorter half-life than isoform 1, degraded via a proteasome-dependent pathway)

Explore the universe of human proteins at neXtProt for SLC28A3: NX_Q9HAS3

Explore proteomics data for SLC28A3 at MOPED


See SLC28A3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001186562.1  NP_071410.1  

ENSEMBL proteins: 
 ENSP00000365413   ENSP00000446438  
Reactome Protein details: Q9HAS3

SLC28A3 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for SLC28A3
OriGene Custom MassSpec
OriGene Custom Protein Services for SLC28A3
GenScript Custom Purified and Recombinant Proteins Services for SLC28A3
Novus Biologicals SLC28A3 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for SLC28A3

 
Search eBioscience for Proteins for SLC28A3 

 
Search antibodies-online for proteins for SLC28A3 

 
Search antibodies-online for peptides for SLC28A3

SLC28A3 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for SLC28A3
Novus Biologicals SLC28A3 Antibodies
Search for Antibodies for SLC28A3 at Abcam
Cloud-Clone Corp. Antibodies for SLC28A3
Search ThermoFisher Antibodies for SLC28A3
Search LSBio for Antibodies for SLC28A3
Search antibodies-online for antibodies for SLC28A3 

SLC28A3 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for SLC28A3
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for SLC28A3
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for SLC28A3
Cloud-Clone Corp. CLIAs for SLC28A3
Search eBioscience for ELISAs for SLC28A3 
antibodies-online kits for SLC28A3 (6 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
SLC: Solute carriers

IUPHAR Guide to PHARMACOLOGY protein family classification: CNT3
SLC28 family

5 InterPro protein domains:
 IPR018270 C_nuclsd_transpt_met_bac
 IPR008276 C_nuclsd_transpt
 IPR002668 Nuclsd_transpt2
 IPR011657 Nucleos_tra2_C
 IPR011642 Nucleoside_recog_Gate

Graphical View of Domain Structure for InterPro Entry Q9HAS3

ProtoNet protein and cluster: Q9HAS3

2 Blocks protein domains:
IPB002668 Na+ dependent nucleoside transporter
IPB011642 Nucleoside recognition


UniProtKB/Swiss-Prot: S28A3_HUMAN, Q9HAS3
Similarity: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family


Find genes that share domains with SLC28A3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: S28A3_HUMAN, Q9HAS3
Function: Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous
nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib)
(with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to
transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine
Biophysicochemical properties: Kinetic parameters: KM=21.6 uM for uridine; KM=15.4 uM for cytidine; KM=21.2 uM for
thymidine; KM=15.1 uM for adenosine; KM=43 uM for guanosine; KM=52.5 uM for inosine; Vmax=25.8 pmol/min/mg enzyme
for uridine uptake; Vmax=32.8 pmol/min/mg enzyme for cytidine uptake; Vmax=24.2 pmol/min/mg enzyme for thymidine
uptake; Vmax=30.4 pmol/min/mg enzyme for adenosine uptake; Vmax=51.4 pmol/min/mg enzyme for guanosine uptake;
Vmax=44.8 pmol/min/mg enzyme for inosine uptake;
Induction: Up-regulated by phorbol myristate acetate (PMA) in HL-60 cells

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001882nucleoside binding IEA--
GO:0005415nucleoside:sodium symporter activity ----
GO:0015389pyrimidine- and adenine-specific:sodium symporter activity IEA--
GO:0015390purine-specific nucleoside:sodium symporter activity IEA--
     
Find genes that share ontologies with SLC28A3           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for SLC28A3:
 Elongated cells  Increased S DNA content 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC28A3
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC28A3

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC28A3
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC28A3

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat SLC28A3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate SLC28A3 (see all 30):
hsa-miR-320a hsa-miR-642a hsa-miR-197 hsa-miR-1205 hsa-miR-515-5p hsa-miR-4298 hsa-miR-1302 hsa-miR-3122
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for SLC28A3
Predesigned siRNA for gene silencing in human, mouse, rat SLC28A3

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for SLC28A3

Clone
Products:
     
OriGene clones in human, mouse for SLC28A3 (see all 5)
OriGene ORF clones in mouse, rat for SLC28A3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): SLC28A3 (NM_001199633)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC28A3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC28A3

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for SLC28A3
Browse ESI BIO Cell Lines and PureStem Progenitors for SLC28A3 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC28A3


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
S28A3_HUMAN, Q9HAS3: Isoform 1: Cell membrane; Multi-pass membrane protein
S28A3_HUMAN, Q9HAS3: Isoform 2: Endoplasmic reticulum membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane4
cytosol2
nucleus2
lysosome1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005789endoplasmic reticulum membrane IEA--
GO:0005886plasma membrane TAS--
GO:0016020membrane ----
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with SLC28A3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for SLC28A3 About    
See pathways by source

SuperPathContained pathways About
1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
SLC-mediated transmembrane transport0.47
Transmembrane transport of small molecules0.47
2Transport of vitamins, nucleosides, and related molecules
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane0.00
Transport of vitamins, nucleosides, and related molecules
3One carbon pool by folate
Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics0.34
4Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics
Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics
5Gemcitabine Pathway, Pharmacodynamics
Gemcitabine Pathway, Pharmacodynamics


Find genes that share SuperPaths with SLC28A3           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for SLC28A3
    Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

3 PharmGKB Pathways for SLC28A3
    Gemcitabine Pathway, Pharmacodynamics
Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics
Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics

    Pathway & Disease-focused RT2 Profiler PCR Array including SLC28A3: 
          Drug Transporters in human mouse rat

Interactions:

    GeneGlobe Interaction Network for SLC28A3

Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006810transport ----
GO:0015860purine nucleoside transmembrane transport ----
GO:0015864pyrimidine nucleoside transport IEA--
GO:0055085transmembrane transport TAS--

Find genes that share ontologies with SLC28A3           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SLC28A3 (S28A3)

2 HMDB Compounds for SLC28A3    About this table
CompoundSynonyms CAS #PubMed Ids
SodiumSodium (see all 2)7440-23-5--
Thymidine1-(2-Deoxy-b-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione (see all 17)50-89-5--

7 DrugBank Compounds for SLC28A3    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Adenosine2'-Deoxyadenosine (see all 11)58-61-7transporter--15738947
Cladribine2-CdA (see all 5)4291-63-8transporter--15738947
Deoxythymidine2'-Deoxythymidine (see all 4)50-89-5transporter--15738947
FludarabineFAMP (see all 4)75607-67-9transporter--15738947
GemcitabinedFdC (see all 4)95058-81-4transportersubstrate19164483
RibavirinRBV (see all 4)36791-04-5transportersubstrate20096989
Mercaptopurine6 MP (see all 5)50-44-2transportersubstrate--

4 Novoseek inferred chemical compound relationships for SLC28A3 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
nucleoside 80.1 25 15738947 (2), 18827020 (2), 15861042 (2), 14668133 (1) (see all 10)
purine 59.1 2 11032837 (1), 15861042 (1)
pyrimidine 57.4 1 12856181 (1)
gemcitabine 44.3 1 14581375 (1)

2 PharmGKB related drug/compound annotations for SLC28A3 gene    About this table
Drug/compound PharmGKB Annotation
anthracyclines and related substancesCA  
gemcitabineCA  



Find genes that share compounds with SLC28A3           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for SLC28A3 gene (2 alternative transcripts): 
NM_001199633.1  NM_022127.2  

Unigene Cluster for SLC28A3:

Solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
Hs.535966  [show with all ESTs]
Unigene Representative Sequence: NR_037638
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000376238(uc011lsy.2 uc010mpz.3 uc004anu.2) ENST00000495823
ENST00000537648(uc010mqb.3)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat SLC28A3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate SLC28A3 (see all 30):
hsa-miR-320a hsa-miR-642a hsa-miR-197 hsa-miR-1205 hsa-miR-515-5p hsa-miR-4298 hsa-miR-1302 hsa-miR-3122
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for SLC28A3
Predesigned siRNA for gene silencing in human, mouse, rat SLC28A3
Clone
Products:
     
OriGene clones in human, mouse for SLC28A3 (see all 5)
OriGene ORF clones in mouse, rat for SLC28A3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): SLC28A3 (NM_001199633)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC28A3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC28A3
Primer
Products:
    
OriGene qPCR primer pairs and template standards for SLC28A3
OriGene qSTAR qPCR primer pairs in human, mouse for SLC28A3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC28A3
  QuantiTect SYBR Green Assays in human, mouse, rat SLC28A3
  QuantiFast Probe-based Assays in human, mouse, rat SLC28A3

Additional mRNA sequence: 

AF305210.1 AK022042.1 AK292849.1 AK304406.1 AK310861.1 AK314039.1 BC093821.1 BC093823.1 
NR_037638.2 

4 DOTS entries:

DT.40270630  DT.102821704  DT.95286447  DT.99927784 

Selected AceView cDNA sequences (see all 28):

AI274238 AF305210 AI304899 AK022042 CD356117 AU120734 BF433068 AI692813 
BF063569 BU685783 NM_022127 AW340625 BM766944 BX956954 BP364577 BF000546 
BF063097 AA643687 BX951041 CB241597 AU146721 AI091154 D20754 BM740922 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SLC28A3    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19
SP1:                    -                                                                       -                                             
SP2:                                                                                                                                          
SP3:                                                                                                                                          


ECgene alternative splicing isoforms for SLC28A3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

SLC28A3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
SLC28A3 Expression
About this image

SLC28A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SLC28A3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.535966

UniProtKB/Swiss-Prot: S28A3_HUMAN, Q9HAS3
Tissue specificity: Expressed in pancreas, bone marrow, trachea, mammary gland, liver, prostate, and regions of
intestine, brain, lung, placenta, testis, kidney, and heart

    Pathway & Disease-focused RT2 Profiler PCR Array including SLC28A3: 
          Drug Transporters in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for SLC28A3
OriGene qSTAR qPCR primer pairs in human, mouse for SLC28A3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC28A3
QuantiTect SYBR Green Assays in human, mouse, rat SLC28A3
QuantiFast Probe-based Assays in human, mouse, rat SLC28A3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC28A3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for SLC28A3 gene from Selected species (see all 17)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Slc28a31 , 5 solute carrier family 28 (sodium-coupled nucleoside more1, 5 81.11(n)1
78.62(a)1
  13 (31.07 cM)5
1143041  NM_022317.31  NP_071712.31 
 585453995 
chicken
(Gallus gallus)
Aves SLC28A31 solute carrier family 28 (sodium-coupled nucleoside more 68.28(n)
64.85(a)
  427459  XM_004949211.1  XP_004949268.1 
lizard
(Anolis carolinensis)
Reptilia SLC28A36
solute carrier family 28 (concentrative nucleoside...
57(a)
1 ↔ 1
2(42432646-42492976)
tropical clawed frog
(Xenopus tropicalis)
Amphibia slc28a31 solute carrier family 28 (sodium-coupled nucleoside more 64.34(n)
64.49(a)
  100492606  XM_002934977.2  XP_002935023.2 
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.71002 Oncorhynchus mykiss transcribed sequence with moderate more 75.16(n)    BX872381.1 
fruit fly
(Drosophila melanogaster)
Insecta BEST:CK004593
CG80831
nucleoside:sodium symporter3
CG80831
44(a)
(best of 2)3
53.38(n)1
44.63(a)1
  45A13
359141  NM_136602.41  NP_610446.11 
worm
(Caenorhabditis elegans)
Secernentea F27E11.13
F27E11.21
nucleoside transporter3
F27E11.21
35(a)3
47.7(n)1
35.04(a)1
  V(3463660-3465965)3
1787691  NM_071565.41  NP_503966.21 


ENSEMBL Gene Tree for SLC28A3 (if available)
TreeFam Gene Tree for SLC28A3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for SLC28A3 gene
SLC28A22  SLC28A12  
2 SIMAP similar genes for SLC28A3 using alignment to 1 protein entry:     S28A3_HUMAN:
SLC28A1    SLC28A2

Find genes that share paralogs with SLC28A3           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for SLC28A3 (see all 2324)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs123466781,2
C,F,H--86890313(+) TGGGTG/AGACTG 3 -- int17Minor allele frequency- A:0.01NS EA NA 710
rs286751981,2
C--86890328(+) GAGTAC/TGGAGT 3 -- int10--------
rs1490124511,2
C--86890358(+) AGCCCC/TGGCTT 3 -- int10--------
rs1890147761,2
--86890376(+) GGTTGC/GGGAGC 3 -- int10--------
rs1438379751,2
--86890411(+) AACAGC/TGAGCG 3 -- int10--------
rs108681321,2
C,F,A,H--86890592(+) GCCACT/GTACGA 3 -- int124Minor allele frequency- G:0.14NA NS EA WA 2788
rs1385277241,2
--86890598(+) TACGAC/TGTTCA 3 -- int10--------
rs125542651,2
H--86890623(+) GGTTTC/TTGGGG 3 -- int14Minor allele frequency- T:0.00NS EA 420
rs1411765621,2
--86890749(+) TAATAA/CGGAAT 3 -- int10--------
rs174269611,2
C,F,H--86890758(+) ATCAAC/TGTAGG 3 -- int1 ese325Minor allele frequency- T:0.10NA NS EA WA 2908

HapMap Linkage Disequilibrium report for SLC28A3 (86890372 - 86983413 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for SLC28A3:    About this table    
Variant IDTypeSubtypePubMed ID
nsv893518CNV Loss21882294
esv34058CNV Loss18971310
nsv8542CNV Loss18304495
nsv893519CNV Gain21882294
nsv436717OTHER Inversion17901297

Human Gene Mutation Database (HGMD): SLC28A3
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SLC28A3
DNA2.0 Custom Variant and Variant Library Synthesis for SLC28A3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 608269    OMIM disorders: --


Find genes that share disorders with SLC28A3           About GenesLikeMe

Genetic Association Database (GAD): SLC28A3
Human Genome Epidemiology (HuGE) Navigator: SLC28A3 (4 documents)

Export disorders for SLC28A3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for SLC28A3 gene, integrated from 10 sources (see all 52):
(articles sorted by number of sources associating them with SLC28A3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3). (PubMed id 15738947)1, 2, 7, 9 Badagnani I....Giacomini K.M. (Pharmacogenomics J. 2005)
  2. Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). (PubMed id 11032837)1, 2, 3, 9 Ritzel M.W.L.... Young J.D. (J. Biol. Chem. 2001)
  3. A splice variant of the SLC28A3 gene encodes a novel human concentrative nucleoside transporter-3 (hCNT3) protein localized in the endoplasmic reticulum. (PubMed id 18827020)1, 2, 9 Errasti-Murugarren E....Pastor-Anglada M. (FASEB J. 2009)
  4. Identification and functional characterization of variants in human concentrative nucleoside transporter 3, hCNT3 (SLC28A3), arising from single nucleotide polymorphisms in coding regions of the hCNT3 gene. (PubMed id 15861042)1, 2, 9 Damaraju S....Cass C.E. (Pharmacogenet. Genomics 2005)
  5. Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity. (PubMed id 20028759)1, 4 Okazaki T....Li D. (Clin. Cancer Res. 2010)
  6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  7. Genome-wide association of lipid-lowering response to statins in combined study populations. (PubMed id 20339536)1, 4 Barber M.J....Krauss R.M. (PLoS ONE 2010)
  8. Functional characterization of a nucleoside-derived drug transporter variant (hCNT3C602R) showing altered sodium-binding capacity. (PubMed id 17993510)1, 2 Errasti-Murugarren E....Casado F.J. (Mol. Pharmacol. 2008)
  9. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (Cancer Res. 2008)
  10. Electrophysiological characterization and modeling of the structure activity relationship of the human concentrative nucleoside transporter 3 (hCNT3). (PubMed id 16446384)1, 2 Hu H.... Unadkat J.D. (Mol. Pharmacol. 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 64078 HGNC: 16484 AceView: SLC28A3 Ensembl:ENSG00000197506 euGenes: HUgn64078
ECgene: SLC28A3 H-InvDB: SLC28A3

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for SLC28A3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for SLC28A3 gene:
Search GeneIP for patents involving SLC28A3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SLC28A3  
 OriGene qPCR primer pairs and template standards for SLC28A3   OriGene Protein Over-expression Lysate for SLC28A3  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC28A3  
 OriGene qSTAR qPCR primer pairs in human, mouse for SLC28A3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for SLC28A3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for SLC28A3   OriGene Custom Protein Services for SLC28A3  

 
 
 Block miRNA regulation of human, mouse, rat SLC28A3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLC28A3
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC28A3 Predesigned siRNA for gene silencing in human, mouse, rat SLC28A3
 QuantiFast Probe-based Assays in human, mouse, rat SLC28A3 QuantiTect SYBR Green Assays in human, mouse, rat SLC28A3
 PCR Arrays including human, mouse, rat SLC28A3 Search Chromatin IP Primers for SLC28A3
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC28A3  GeneGlobe Interaction Network for SLC28A3
 Search Regulatory tfbs for SLC28A3
 GenScript Custom Purified and Recombinant Proteins Services for SLC28A3 GenScript cDNA clones with any tag delivered in your preferred vector for SLC28A3
 GenScript Custom Assay Services for SLC28A3 GenScript Custom overexpressing Cell Line Services for SLC28A3
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for SLC28A3 (S28A3)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 SLC28A3 antibodies
 SLC28A3 lysates
 Search for Antibodies for SLC28A3 at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for SLC28A3
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for SLC28A3
 Antibodies for SLC28A3
 ELISAs for SLC28A3
 CLIAs for SLC28A3



 Browse ESI BIO Cell Lines and PureStem Progenitors for SLC28A3
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC28A3
 Browse SwitchGear 3'UTR luciferase reporter plasmids for SLC28A3
 SwitchGear Promoter luciferase reporter plasmids for SLC28A3
 Search ThermoFisher Antibodies for SLC28A3
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC28A3
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC28A3
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC28A3
 Search LSBio for Antibodies for SLC28A3
 Browse compounds at ApexBio
 Search Addgene for plasmids for SLC28A3
  Search eBioscience for proteins for SLC28A3
  Search eBioscience for elisas for SLC28A3
  eBioscience FlowRNA Probe Sets
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
  Search antibodies-online for antibodies for SLC28A3
 antibodies-online kits for SLC28A3 (6 products)
  Search antibodies-online for peptides for SLC28A3
  Search antibodies-online for proteins for SLC28A3
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      SLC28A3 gene at Home site.
Version: 3.12.234 23 Oct 2014
hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4