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Aliases for SLC28A3 Gene

Aliases for SLC28A3 Gene

  • Solute Carrier Family 28 Member 3 2 3 5
  • Solute Carrier Family 28 (Sodium-Coupled Nucleoside Transporter), Member 3 2 3
  • Solute Carrier Family 28 (Concentrative Nucleoside Transporter), Member 3 2 3
  • Concentrative Na(+)-Nucleoside Cotransporter 3 3 4
  • CNT3 3 4
  • Concentrative Na+-Nucleoside Cotransporter 3
  • CNT 3 4
  • HCNT3 4

External Ids for SLC28A3 Gene

Previous GeneCards Identifiers for SLC28A3 Gene

  • GC09M077936
  • GC09M078744
  • GC09M080445
  • GC09M082350
  • GC09M084122
  • GC09M086080
  • GC09M086890
  • GC09M056719

Summaries for SLC28A3 Gene

Entrez Gene Summary for SLC28A3 Gene

  • Nucleoside transporters, such as SLC28A3, regulate multiple cellular processes, including neurotransmission, vascular tone, adenosine concentration in the vicinity of cell surface receptors, and transport and metabolism of nucleoside drugs. SLC28A3 shows broad specificity for pyrimidine and purine nucleosides (Ritzel et al., 2001 [PubMed 11032837]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC28A3 Gene

SLC28A3 (Solute Carrier Family 28 Member 3) is a Protein Coding gene. Among its related pathways are Gemcitabine Pathway, Pharmacokinetics/Pharmacodynamics and Transport of vitamins, nucleosides, and related molecules. GO annotations related to this gene include nucleoside binding and pyrimidine- and adenine-specific:sodium symporter activity. An important paralog of this gene is SLC28A1.

UniProtKB/Swiss-Prot for SLC28A3 Gene

  • Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3-azido-3-deoxythymidine (AZT), ribavirin and 3-deazauridine.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC28A3 Gene

Genomics for SLC28A3 Gene

Regulatory Elements for SLC28A3 Gene

Enhancers for SLC28A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F084366 1.1 Ensembl ENCODE 14.4 +0.8 784 2.5 INSM2 KLF17 FEZF1 ZNF2 ZEB1 ZNF335 ZNF366 ZNF391 EGR2 SP3 SLC28A3 LOC105376116
GH09F084322 0.8 Ensembl ENCODE 17.3 +44.8 44832 2.0 ZNF121 MAFK ATF2 PRDM1 SLC28A3 LOC105376116
GH09F084331 1.1 Ensembl ENCODE 6.4 +37.1 37096 1.1 CTCF ZSCAN5A ZNF837 SIN3A ZNF2 RAD21 ZNF335 HIC1 CTBP1 SCRT2 LOC105376116 SLC28A3
GH09F084342 1.1 Ensembl ENCODE 5.6 +25.5 25462 0.6 BCOR HDAC1 ZNF146 ATF1 TBL1XR1 TAL1 ZMYM3 ZNF175 CCNT2 GATA2 SLC28A3 LOC105376116
GH09F084340 0.6 Ensembl ENCODE 9.4 +28.0 27982 0.5 KLF1 SLC28A3 LOC105376116
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC28A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC28A3 Gene

Chromosome:
9
Start:
84,275,457 bp from pter
End:
84,368,632 bp from pter
Size:
93,176 bases
Orientation:
Minus strand

Genomic View for SLC28A3 Gene

Genes around SLC28A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC28A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC28A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC28A3 Gene

Proteins for SLC28A3 Gene

  • Protein details for SLC28A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAS3-S28A3_HUMAN
    Recommended name:
    Solute carrier family 28 member 3
    Protein Accession:
    Q9HAS3
    Secondary Accessions:
    • A8K9Y4
    • B1AML0
    • B2RA51
    • B4E2S8
    • F5GYE3

    Protein attributes for SLC28A3 Gene

    Size:
    691 amino acids
    Molecular mass:
    76930 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC28A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC28A3 Gene

Post-translational modifications for SLC28A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC28A3 Gene

No data available for DME Specific Peptides for SLC28A3 Gene

Domains & Families for SLC28A3 Gene

Gene Families for SLC28A3 Gene

HGNC:
IUPHAR :

Suggested Antigen Peptide Sequences for SLC28A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HAS3

UniProtKB/Swiss-Prot:

S28A3_HUMAN :
  • Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
Family:
  • Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
genes like me logo Genes that share domains with SLC28A3: view

Function for SLC28A3 Gene

Molecular function for SLC28A3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=21.6 uM for uridine {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; KM=15.4 uM for cytidine {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; KM=21.2 uM for thymidine {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; KM=15.1 uM for adenosine {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; KM=43 uM for guanosine {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; KM=52.5 uM for inosine {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; Vmax=25.8 pmol/min/mg enzyme for uridine uptake {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; Vmax=32.8 pmol/min/mg enzyme for cytidine uptake {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; Vmax=24.2 pmol/min/mg enzyme for thymidine uptake {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; Vmax=30.4 pmol/min/mg enzyme for adenosine uptake {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; Vmax=51.4 pmol/min/mg enzyme for guanosine uptake {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; Vmax=44.8 pmol/min/mg enzyme for inosine uptake {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042};
UniProtKB/Swiss-Prot Function:
Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3-azido-3-deoxythymidine (AZT), ribavirin and 3-deazauridine.
UniProtKB/Swiss-Prot Induction:
Up-regulated by phorbol myristate acetate (PMA) in HL-60 cells.

Gene Ontology (GO) - Molecular Function for SLC28A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005415 nucleoside:sodium symporter activity TAS --
GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity IEA,IBA --
GO:0015390 purine-specific nucleoside:sodium symporter activity IEA,IBA --
genes like me logo Genes that share ontologies with SLC28A3: view
genes like me logo Genes that share phenotypes with SLC28A3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC28A3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC28A3 Gene

Localization for SLC28A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC28A3 Gene

Isoform 1: Cell membrane; Multi-pass membrane protein.
Isoform 2: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC28A3 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC28A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC28A3: view

Pathways & Interactions for SLC28A3 Gene

genes like me logo Genes that share pathways with SLC28A3: view

Interacting Proteins for SLC28A3 Gene

Gene Ontology (GO) - Biological Process for SLC28A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015855 pyrimidine nucleobase transport IEA --
GO:0015860 purine nucleoside transmembrane transport IEA --
GO:0015864 pyrimidine nucleoside transport IEA,IBA --
GO:0072531 pyrimidine-containing compound transmembrane transport IEA --
GO:1901642 nucleoside transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC28A3: view

No data available for SIGNOR curated interactions for SLC28A3 Gene

Drugs & Compounds for SLC28A3 Gene

(12) Drugs for SLC28A3 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gemcitabine Approved Pharma Transporter, substrate Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1974
Ribavirin Approved Pharma Transporter, substrate 984
Adenosine Approved, Investigational Pharma Agonist, Transporter 397
Cladribine Approved, Investigational Pharma Transporter Apoptosis inducer in CLL cells 71
Fludarabine Approved Pharma Transporter DNA synthsis inhibitor 1113,1113

(4) Additional Compounds for SLC28A3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC28A3: view

Transcripts for SLC28A3 Gene

Unigene Clusters for SLC28A3 Gene

Solute carrier family 28 (sodium-coupled nucleoside transporter), member 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC28A3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19
SP1: - -
SP2:
SP3:

Relevant External Links for SLC28A3 Gene

GeneLoc Exon Structure for
SLC28A3
ECgene alternative splicing isoforms for
SLC28A3

Expression for SLC28A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC28A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC28A3 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x7.7), Minor Salivary Gland (x7.4), Breast - Mammary Tissue (x7.3), Skin - Not Sun Exposed (Suprapubic) (x6.4), and Pancreas (x6.1).

Protein differential expression in normal tissues from HIPED for SLC28A3 Gene

This gene is overexpressed in Heart (38.3) and Brain (30.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC28A3 Gene



Protein tissue co-expression partners for SLC28A3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC28A3 Gene:

SLC28A3

SOURCE GeneReport for Unigene cluster for SLC28A3 Gene:

Hs.535966

mRNA Expression by UniProt/SwissProt for SLC28A3 Gene:

Q9HAS3-S28A3_HUMAN
Tissue specificity: Expressed in pancreas, bone marrow, trachea, mammary gland, liver, prostate, and regions of intestine, brain, lung, placenta, testis, kidney, and heart.
genes like me logo Genes that share expression patterns with SLC28A3: view

Primer Products

Orthologs for SLC28A3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC28A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC28A3 34 35
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia SLC28A3 34
  • 85.22 (n)
cow
(Bos Taurus)
Mammalia SLC28A3 34 35
  • 84.69 (n)
mouse
(Mus musculus)
Mammalia Slc28a3 34 16 35
  • 81.11 (n)
rat
(Rattus norvegicus)
Mammalia Slc28a3 34
  • 79.94 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC28A3 35
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC28A3 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC28A3 34 35
  • 68.28 (n)
lizard
(Anolis carolinensis)
Reptilia SLC28A3 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc28a3 34
  • 64.34 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7100 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005988 34
  • 54 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8083 34 35
  • 53.38 (n)
BEST:CK00459 36
  • 44 (a)
CG11778 36
  • 42 (a)
CNT1 35
  • 32 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F27E11.2 34
  • 47.7 (n)
F27E11.1 36
  • 35 (a)
slc-28.2 35
  • 30 (a)
ManyToMany
slc-28.1 35
  • 29 (a)
ManyToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU08148 34
  • 48.7 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5907 34
Species where no ortholog for SLC28A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC28A3 Gene

ENSEMBL:
Gene Tree for SLC28A3 (if available)
TreeFam:
Gene Tree for SLC28A3 (if available)

Paralogs for SLC28A3 Gene

Paralogs for SLC28A3 Gene

(2) SIMAP similar genes for SLC28A3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC28A3: view

Variants for SLC28A3 Gene

Sequence variations from dbSNP and Humsavar for SLC28A3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10114852 -- 84,316,778(+) cgggc(A/G)gatga intron-variant
rs10114877 -- 84,316,870(+) GTGGC(A/G)GGCAC intron-variant
rs10115380 -- 84,357,734(+) AAGGG(C/T)CTAAA intron-variant
rs10116553 -- 84,318,955(+) ataaa(C/T)ggaga intron-variant
rs10118014 -- 84,316,932(+) ggaag(C/T)ggagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC28A3 Gene

Variant ID Type Subtype PubMed ID
esv34058 CNV loss 18971310
nsv1044953 CNV gain 25217958
nsv1048977 CNV gain 25217958
nsv436717 OTHER inversion 17901297
nsv8542 CNV loss 18304495

Variation tolerance for SLC28A3 Gene

Residual Variation Intolerance Score: 70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.64; 86.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC28A3 Gene

Human Gene Mutation Database (HGMD)
SLC28A3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC28A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC28A3 Gene

Disorders for SLC28A3 Gene

Relevant External Links for SLC28A3

Genetic Association Database (GAD)
SLC28A3
Human Genome Epidemiology (HuGE) Navigator
SLC28A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC28A3

No disorders were found for SLC28A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC28A3 Gene

Publications for SLC28A3 Gene

  1. Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). (PMID: 11032837) Ritzel M.W.L. … Young J.D. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. A splice variant of the SLC28A3 gene encodes a novel human concentrative nucleoside transporter-3 (hCNT3) protein localized in the endoplasmic reticulum. (PMID: 18827020) Errasti-Murugarren E. … Pastor-Anglada M. (FASEB J. 2009) 3 4 22 64
  3. Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3). (PMID: 15738947) Badagnani I. … Giacomini K.M. (Pharmacogenomics J. 2005) 3 4 22 64
  4. Identification and functional characterization of variants in human concentrative nucleoside transporter 3, hCNT3 (SLC28A3), arising from single nucleotide polymorphisms in coding regions of the hCNT3 gene. (PMID: 15861042) Damaraju S. … Cass C.E. (Pharmacogenet. Genomics 2005) 3 4 22 64
  5. Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity. (PMID: 20028759) Okazaki T. … Li D. (Clin. Cancer Res. 2010) 3 46 64

Products for SLC28A3 Gene

Sources for SLC28A3 Gene

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