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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC28A3 Gene

protein-coding   GIFtS: 54
GCID: GC09M086890

Solute Carrier Family 28 (Concentrative Nucleoside Transporter),...

(Previous names: solute carrier family 28 (sodium-coupled nucleoside transporter),...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 28 (Concentrative Nucleoside Transporter), Member
31 2
     Concentrative Na+-Nucleoside Cotransporter2
CNT32 3 5     Solute Carrier Family 28 Member 32
Solute Carrier Family 28 (Sodium-Coupled Nucleoside Transporter), Member 31 2     CNT 33
Concentrative Na(+)-Nucleoside Cotransporter 32 3     hCNT33

External Ids:    HGNC: 164841   Entrez Gene: 640782   Ensembl: ENSG000001975067   OMIM: 6082695   UniProtKB: Q9HAS33   

Export aliases for SLC28A3 gene to outside databases

Previous GC identifers: GC09M077936 GC09M078744 GC09M080445 GC09M082350 GC09M084122 GC09M086080 GC09M056719


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC28A3 Gene:
Nucleoside transporters, such as SLC28A3, regulate multiple cellular processes, including neurotransmission,
vascular tone, adenosine concentration in the vicinity of cell surface receptors, and transport and metabolism of
nucleoside drugs. SLC28A3 shows broad specificity for pyrimidine and purine nucleosides (Ritzel et al., 2001
(PubMed 11032837)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SLC28A3 Gene: 
SLC28A3 (solute carrier family 28 (concentrative nucleoside transporter), member 3) is a protein-coding gene. Diseases associated with SLC28A3 include choriocarcinoma, and chronic lymphocytic leukemia, and among its related super-pathways are Transmembrane transport of small molecules and Antimetabolite Pathway - Folate Cycle, Pharmacodynamics. GO annotations related to this gene include purine-specific nucleoside:sodium symporter activity and nucleoside binding. An important paralog of this gene is SLC28A2.

UniProtKB/Swiss-Prot: S28A3_HUMAN, Q9HAS3
Function: Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous
nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib)
(with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to
transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SLC28A3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC28A3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC28A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC28A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.2   Ensembl cytogenetic band:  9q21.33   HGNC cytogenetic band: 9q21.33

SLC28A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC28A3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M086890:  view genomic region     (about GC identifiers)

Start:
86,890,372 bp from pter      End:
86,983,413 bp from pter
Size:
93,042 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S28A3_HUMAN, Q9HAS3 (See protein sequence)
Recommended Name: Solute carrier family 28 member 3  
Size: 691 amino acids; 76930 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A8K9Y4 B1AML0

Explore the universe of human proteins at neXtProt for SLC28A3: NX_Q9HAS3

Explore proteomics data for SLC28A3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HAS3

  • SLC28A3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC28A3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001186562.1  NP_071410.1  

    ENSEMBL proteins: 
     ENSP00000365413   ENSP00000446438  
    Reactome Protein details: Q9HAS3
    Human Recombinant Protein Products for SLC28A3: 
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    Cloud-Clone Corp. Proteins for SLC28A3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    SLC28A3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: CNT3 
    SLC28 family

    5 InterPro protein domains:
     IPR018270 C_nuclsd_transpt_met_bac
     IPR008276 C_nuclsd_transpt
     IPR002668 Nuclsd_transpt2
     IPR011642 Nucleoside_recog_Gate
     IPR011657 Nucleos_tra2_C

    Graphical View of Domain Structure for InterPro Entry Q9HAS3

    ProtoNet protein and cluster: Q9HAS3

    2 Blocks protein domains:
    IPB002668 Na+ dependent nucleoside transporter
    IPB011642 Nucleoside recognition


    UniProtKB/Swiss-Prot: S28A3_HUMAN, Q9HAS3
    Similarity: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family


    SLC28A3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S28A3_HUMAN, Q9HAS3
    Function: Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous
    nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib)
    (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to
    transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine
    Biophysicochemical properties: Kinetic parameters: KM=21.6 uM for uridine; KM=15.4 uM for cytidine; KM=21.2 uM for
    thymidine; KM=15.1 uM for adenosine; KM=43 uM for guanosine; KM=52.5 uM for inosine; Vmax=25.8 pmol/min/mg enzyme
    for uridine uptake; Vmax=32.8 pmol/min/mg enzyme for cytidine uptake; Vmax=24.2 pmol/min/mg enzyme for thymidine
    uptake; Vmax=30.4 pmol/min/mg enzyme for adenosine uptake; Vmax=51.4 pmol/min/mg enzyme for guanosine uptake;
    Vmax=44.8 pmol/min/mg enzyme for inosine uptake;
    Induction: Up-regulated by phorbol myristate acetate (PMA) in HL-60 cells

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001882nucleoside binding IEA--
    GO:0005415nucleoside:sodium symporter activity ----
    GO:0015389pyrimidine- and adenine-specific:sodium symporter activity IEA--
    GO:0015390purine-specific nucleoside:sodium symporter activity IEA--
         
    SLC28A3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SLC28A3:
     Elongated cells  Increased S DNA content 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC28A3 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transmembrane transport of small molecules0.50
    2Antimetabolite Pathway - Folate Cycle, Pharmacodynamics
    Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics0.36
    3Transport of organic anions
    Transport of vitamins, nucleosides, and related molecules0.34
    4Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics
    Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics
    5Gemcitabine Pathway, Pharmacodynamics
    Gemcitabine Pathway, Pharmacodynamics

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for SLC28A3
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
    Transport of vitamins, nucleosides, and related molecules

    3 PharmGKB Pathways for SLC28A3
        Gemcitabine Pathway, Pharmacodynamics
    Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics
    Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics


    SLC28A3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC28A3

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0015860purine nucleoside transmembrane transport ----
    GO:0015864pyrimidine nucleoside transport IEA--
    GO:0055085transmembrane transport TAS--

    SLC28A3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC28A3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SLC28A3 (S28A3)

    2 HMDB Compounds for SLC28A3    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--
    Thymidine1-(2-Deoxy-b-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione (see all 17)50-89-5--

    7 DrugBank Compounds for SLC28A3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine2'-Deoxyadenosine (see all 11)58-61-7transporter--15738947
    Cladribine2-CdA (see all 5)4291-63-8transporter--15738947
    Deoxythymidine2'-Deoxythymidine (see all 4)50-89-5transporter--15738947
    FludarabineFAMP (see all 4)75607-67-9transporter--15738947
    GemcitabinedFdC (see all 4)95058-81-4transportersubstrate19164483
    RibavirinRBV (see all 4)36791-04-5transportersubstrate20096989
    Mercaptopurine6 MP (see all 5)50-44-2transportersubstrate--

    4 Novoseek inferred chemical compound relationships for SLC28A3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nucleoside 80.1 25 15738947 (2), 18827020 (2), 15861042 (2), 14668133 (1) (see all 10)
    purine 59.1 2 11032837 (1), 15861042 (1)
    pyrimidine 57.4 1 12856181 (1)
    gemcitabine 44.3 1 14581375 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC28A3 / S28A3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC28A3 gene (2 alternative transcripts): 
    NM_001199633.1  NM_022127.2  

    Unigene Cluster for SLC28A3:

    Solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
    Hs.535966  [show with all ESTs]
    Unigene Representative Sequence: NR_037638
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376238(uc011lsy.2 uc010mpz.3 uc004anu.2) ENST00000495823
    ENST00000537648(uc010mqb.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF305210.1 AK022042.1 AK292849.1 AK304406.1 AK310861.1 AK314039.1 BC093821.1 BC093823.1 
    NR_037638.2 

    4 DOTS entries:

    DT.40270630  DT.102821704  DT.95286447  DT.99927784 

    24/28 AceView cDNA sequences (see all 28):

    AK022042 BU685783 AI274238 AI692813 BF433068 NM_022127 AF305210 AI304899 
    BF063569 CD356117 AU120734 BF000546 BP364577 AA643687 AW340625 BF063097 
    BX951041 BX956954 BM766944 CB241597 AI091154 D20754 AU146721 BM740922 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SLC28A3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19
    SP1:                    -                                                                       -                                             
    SP2:                                                                                                                                          
    SP3:                                                                                                                                          


    ECgene alternative splicing isoforms for SLC28A3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC28A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC28A3 Expression
    About this image


    See SLC28A3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC28A3

    SOURCE GeneReport for Unigene cluster: Hs.535966

    UniProtKB/Swiss-Prot: S28A3_HUMAN, Q9HAS3
    Tissue specificity: Expressed in pancreas, bone marrow, trachea, mammary gland, liver, prostate, and regions of
    intestine, brain, lung, placenta, testis, kidney, and heart

        SABiosciences Expression via Pathway-Focused PCR Array including SLC28A3: 
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLC28A3 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc28a31 , 5 solute carrier family 28 (sodium-coupled nucleoside more1, 5 81.31(n)1
    78.92(a)1
      13 (31.07 cM)5
    1143041  NM_022317.31  NP_071712.31 
     585453995 
    chicken
    (Gallus gallus)
    Aves SLC28A31 solute carrier family 28 (sodium-coupled nucleoside more 69.94(n)
    67.72(a)
      427459  XM_425033.3  XP_425033.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLC28A36
    solute carrier family 28 (sodium-coupled nucleosid...
    57(a)
    1 ↔ 1
    2(42432646-42492976)
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.71002 Oncorhynchus mykiss transcribed sequence with moderate more 75.16(n)    BX872381.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BEST:CK004593
    CG80831
    nucleoside:sodium symporter3
    CG80831
    44(a)
    (best of 2)3
    53.38(n)1
    44.63(a)1
      45A13
    359141  NM_206059.21  NP_995781.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F27E11.11 , 3 nucleoside transporter3
    Protein F27E11.11
    35(a)3
    48.32(n)1
    37.35(a)1
      V(3463660-3465965)3
    1787701  NM_071566.21  NP_503967.11 


    ENSEMBL Gene Tree for SLC28A3 (if available)
    TreeFam Gene Tree for SLC28A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC28A3 gene
    SLC28A22  SLC28A12  
    2 SIMAP similar genes for SLC28A3 using alignment to 2 protein entries:     S28A3_HUMAN (see all proteins):
    SLC28A1    SLC28A2

    SLC28A3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2323 SNPs in SLC28A3 are shown (see all 2323)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0396744
    ----see VAR_0396742 G R mis40--------
    VAR_0396784
    ----see VAR_0396782 C R mis40--------
    VAR_0396704
    ----see VAR_0396702 L F mis40--------
    rs123466781,2
    C,F,H--86890313(+) TGGGTG/AGACTG 3 -- int17Minor allele frequency- A:0.01NS EA NA 710
    rs286751981,2
    C--86890328(+) GAGTAC/TGGAGT 3 -- int10--------
    rs1490124511,2
    C--86890358(+) AGCCCC/TGGCTT 3 -- int10--------
    rs1890147761,2
    --86890376(+) GGTTGC/GGGAGC 3 -- int10--------
    rs1438379751,2
    --86890411(+) AACAGC/TGAGCG 3 -- int10--------
    rs108681321,2
    C,F,A,H--86890592(+) GCCACT/GTACGA 3 -- int124Minor allele frequency- G:0.14NA NS EA WA 2788
    rs1385277241,2
    --86890598(+) TACGAC/TGTTCA 3 -- int10--------

    HapMap Linkage Disequilibrium report for SLC28A3 (86890372 - 86983413 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SLC28A3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv893518CNV Loss21882294
    esv34058CNV Loss18971310
    nsv8542CNV Loss18304495
    nsv893519CNV Gain21882294
    nsv436717OTHER Inversion17901297


    Human Gene Mutation Database (HGMD): SLC28A3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC28A3
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC28A3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608269    OMIM disorders: --

    10 diseases for SLC28A3:    About MalaCards
    choriocarcinoma    chronic lymphocytic leukemia    hepatitis c    anemia
    pancreatic cancer    pancreatitis    adenocarcinoma    hepatitis
    leukemia    prostatitis


    SLC28A3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC28A3
    Human Genome Epidemiology (HuGE) Navigator: SLC28A3 (4 documents)

    Export disorders for SLC28A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC28A3 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with SLC28A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3). (PubMed id 15738947)1, 2, 7, 9 Badagnani I....Giacomini K.M. (2005)
    2. Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). (PubMed id 11032837)1, 2, 3, 9 Ritzel M.W.... Young J.D. (2001)
    3. Identification and functional characterization of variants in human concentrative nucleoside transporter 3, hCNT3 (SLC28A3), arising from single nucleotide polymorphisms in coding regions of the hCNT3 gene. (PubMed id 15861042)1, 2, 9 Damaraju S....Cass C.E. (2005)
    4. Single nucleotide polymorphisms of gemcitabine metabo lic genes and pancreatic cancer survival and drug toxicity. (PubMed id 20028759)1, 4 Okazaki T....Li D. (2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Genome-wide association of lipid-lowering response to statins in combined study populations. (PubMed id 20339536)1, 4 Barber M.J....Krauss R.M. (2010)
    7. Functional characterization of a nucleoside-derived drug transporter variant (hCNT3C602R) showing altered sodium-binding capacity. (PubMed id 17993510)1, 2 Errasti-Murugarren E....Casado F.J. (2008)
    8. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (2008)
    9. Electrophysiological characterization and modeling of the structure activity relationship of the human concentrative nucleoside transporter 3 (hCNT3). (PubMed id 16446384)1, 2 Hu H.... Unadkat J.D. (2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64078 HGNC: 16484 AceView: SLC28A3 Ensembl:ENSG00000197506 euGenes: HUgn64078
    ECgene: SLC28A3 H-InvDB: SLC28A3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC28A3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC28A3 gene:
    Search GeneIP for patents involving SLC28A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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