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Aliases for SLC28A3 Gene

Aliases for SLC28A3 Gene

  • Solute Carrier Family 28 Member 3 2 3
  • Solute Carrier Family 28 (Concentrative Nucleoside Transporter), Member 3 2 3 5
  • Solute Carrier Family 28 (Sodium-Coupled Nucleoside Transporter), Member 3 2 3
  • Concentrative Na(+)-Nucleoside Cotransporter 3 3 4
  • CNT3 3 4
  • Concentrative Na+-Nucleoside Cotransporter 3
  • CNT 3 4
  • HCNT3 4

External Ids for SLC28A3 Gene

Previous GeneCards Identifiers for SLC28A3 Gene

  • GC09M077936
  • GC09M078744
  • GC09M080445
  • GC09M082350
  • GC09M084122
  • GC09M086080
  • GC09M086890
  • GC09M056719

Summaries for SLC28A3 Gene

Entrez Gene Summary for SLC28A3 Gene

  • Nucleoside transporters, such as SLC28A3, regulate multiple cellular processes, including neurotransmission, vascular tone, adenosine concentration in the vicinity of cell surface receptors, and transport and metabolism of nucleoside drugs. SLC28A3 shows broad specificity for pyrimidine and purine nucleosides (Ritzel et al., 2001 [PubMed 11032837]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC28A3 Gene

SLC28A3 (Solute Carrier Family 28 Member 3) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics. GO annotations related to this gene include nucleoside binding and pyrimidine- and adenine-specific:sodium symporter activity. An important paralog of this gene is SLC28A2.

UniProtKB/Swiss-Prot for SLC28A3 Gene

  • Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3-azido-3-deoxythymidine (AZT), ribavirin and 3-deazauridine.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC28A3 Gene

Genomics for SLC28A3 Gene

Genomic Location for SLC28A3 Gene

84,275,457 bp from pter
84,368,632 bp from pter
93,176 bases
Minus strand

Genomic View for SLC28A3 Gene

Genes around SLC28A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC28A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC28A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC28A3 Gene

No data available for Regulatory Elements for SLC28A3 Gene

Proteins for SLC28A3 Gene

  • Protein details for SLC28A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 28 member 3
    Protein Accession:
    Secondary Accessions:
    • A8K9Y4
    • B1AML0
    • B2RA51
    • B4E2S8
    • F5GYE3

    Protein attributes for SLC28A3 Gene

    691 amino acids
    Molecular mass:
    76930 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC28A3 Gene


neXtProt entry for SLC28A3 Gene

Proteomics data for SLC28A3 Gene at MOPED

Post-translational modifications for SLC28A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC28A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC28A3 Gene

Domains & Families for SLC28A3 Gene

Gene Families for SLC28A3 Gene


Suggested Antigen Peptide Sequences for SLC28A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
  • Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
genes like me logo Genes that share domains with SLC28A3: view

Function for SLC28A3 Gene

Molecular function for SLC28A3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=21.6 uM for uridine {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; KM=15.4 uM for cytidine {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; KM=21.2 uM for thymidine {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; KM=15.1 uM for adenosine {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; KM=43 uM for guanosine {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; KM=52.5 uM for inosine {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; Vmax=25.8 pmol/min/mg enzyme for uridine uptake {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; Vmax=32.8 pmol/min/mg enzyme for cytidine uptake {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; Vmax=24.2 pmol/min/mg enzyme for thymidine uptake {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; Vmax=30.4 pmol/min/mg enzyme for adenosine uptake {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; Vmax=51.4 pmol/min/mg enzyme for guanosine uptake {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; Vmax=44.8 pmol/min/mg enzyme for inosine uptake {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042};
UniProtKB/Swiss-Prot Function:
Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3-azido-3-deoxythymidine (AZT), ribavirin and 3-deazauridine.
UniProtKB/Swiss-Prot Induction:
Up-regulated by phorbol myristate acetate (PMA) in HL-60 cells.
genes like me logo Genes that share phenotypes with SLC28A3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC28A3

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC28A3 Gene

Localization for SLC28A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC28A3 Gene

Isoform 1: Cell membrane; Multi-pass membrane protein.
Isoform 2: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC28A3 Gene COMPARTMENTS Subcellular localization image for SLC28A3 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC28A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC28A3: view

Pathways & Interactions for SLC28A3 Gene

genes like me logo Genes that share pathways with SLC28A3: view

Interacting Proteins for SLC28A3 Gene

Gene Ontology (GO) - Biological Process for SLC28A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEA --
GO:0006810 transport IEA --
GO:0015864 pyrimidine nucleoside transport IEA,IBA --
GO:0072531 pyrimidine-containing compound transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC28A3: view

No data available for SIGNOR curated interactions for SLC28A3 Gene

Drugs & Compounds for SLC28A3 Gene

(10) Drugs for SLC28A3 Gene - From: DrugBank, PharmGKB, HMDB, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gemcitabine Approved Pharma Transporter, substrate Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1881
Ribavirin Approved Pharma Transporter, substrate 948
Adenosine Approved, Investigational Pharma Agonist, Transporter 363
Cladribine Approved, Investigational Pharma Transporter Apoptosis inducer in CLL cells 67
Fludarabine Approved Pharma Transporter DNA synthsis inhibitor 1059

(4) Additional Compounds for SLC28A3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Sodium
  • Sodium ion
genes like me logo Genes that share compounds with SLC28A3: view

Transcripts for SLC28A3 Gene

Unigene Clusters for SLC28A3 Gene

Solute carrier family 28 (sodium-coupled nucleoside transporter), member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC28A3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19
SP1: - -

Relevant External Links for SLC28A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC28A3 Gene

mRNA expression in normal human tissues for SLC28A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC28A3 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x7.7), Minor Salivary Gland (x7.4), Breast - Mammary Tissue (x7.3), Skin - Not Sun Exposed (Suprapubic) (x6.4), and Pancreas (x6.1).

Protein differential expression in normal tissues from HIPED for SLC28A3 Gene

This gene is overexpressed in Heart (38.3) and Brain (30.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC28A3 Gene

SOURCE GeneReport for Unigene cluster for SLC28A3 Gene Hs.535966

mRNA Expression by UniProt/SwissProt for SLC28A3 Gene

Tissue specificity: Expressed in pancreas, bone marrow, trachea, mammary gland, liver, prostate, and regions of intestine, brain, lung, placenta, testis, kidney, and heart.
genes like me logo Genes that share expression patterns with SLC28A3: view

Protein tissue co-expression partners for SLC28A3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SLC28A3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC28A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC28A3 35
  • 84.69 (n)
  • 79.71 (a)
SLC28A3 36
  • 77 (a)
(Canis familiaris)
Mammalia SLC28A3 35
  • 85.22 (n)
  • 81.88 (a)
(Mus musculus)
Mammalia Slc28a3 35
  • 81.11 (n)
  • 78.62 (a)
Slc28a3 16
Slc28a3 36
  • 74 (a)
(Pan troglodytes)
Mammalia SLC28A3 35
  • 99.42 (n)
  • 99.13 (a)
SLC28A3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slc28a3 35
  • 79.94 (n)
  • 78.48 (a)
(Monodelphis domestica)
Mammalia SLC28A3 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia SLC28A3 36
  • 71 (a)
(Gallus gallus)
Aves SLC28A3 35
  • 68.28 (n)
  • 64.85 (a)
SLC28A3 36
  • 62 (a)
(Anolis carolinensis)
Reptilia SLC28A3 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc28a3 35
  • 64.34 (n)
  • 64.49 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7100 35
fruit fly
(Drosophila melanogaster)
Insecta BEST:CK00459 37
  • 44 (a)
CG11778 37
  • 42 (a)
CG8083 35
  • 53.38 (n)
  • 44.63 (a)
CG8083 36
  • 33 (a)
CNT1 36
  • 32 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005988 35
  • 54 (n)
  • 48.75 (a)
(Caenorhabditis elegans)
Secernentea F27E11.1 37
  • 35 (a)
F27E11.2 35
  • 47.7 (n)
  • 35.04 (a)
slc-28.1 36
  • 29 (a)
slc-28.2 36
  • 30 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5907 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08148 35
  • 48.7 (n)
  • 37.78 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for SLC28A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC28A3 Gene

Gene Tree for SLC28A3 (if available)
Gene Tree for SLC28A3 (if available)

Paralogs for SLC28A3 Gene

Paralogs for SLC28A3 Gene

(2) SIMAP similar genes for SLC28A3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC28A3: view

Variants for SLC28A3 Gene

Sequence variations from dbSNP and Humsavar for SLC28A3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs11568401 - 84,340,623(-) GCTGA(A/G)GAGTA intron-variant, nc-transcript-variant, reference, missense
rs11568403 - 84,340,620(+) CTGTA(C/G/T)TCYTC intron-variant, nc-transcript-variant, reference, missense
rs45621433 - 84,309,687(-) AGCAG(C/G)ATTCT nc-transcript-variant, reference, missense
rs11568411 - 84,309,671(-) AAACA(A/G)AGAAC nc-transcript-variant, reference, missense
rs10868138 - 84,302,386(+) CCAGA(C/T)AACCT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SLC28A3 Gene

Variant ID Type Subtype PubMed ID
nsv436717 OTHER Inversion 17901297
nsv8542 CNV Loss 18304495
esv34058 CNV Loss 18971310
nsv893518 CNV Loss 21882294
nsv893519 CNV Gain 21882294

Variation tolerance for SLC28A3 Gene

Residual Variation Intolerance Score: 70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.64; 86.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC28A3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC28A3 Gene

Disorders for SLC28A3 Gene

Relevant External Links for SLC28A3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC28A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC28A3 Gene

Publications for SLC28A3 Gene

  1. Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). (PMID: 11032837) Ritzel M.W.L. … Young J.D. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3). (PMID: 15738947) Badagnani I. … Giacomini K.M. (Pharmacogenomics J. 2005) 3 23 25
  3. Kinetic study of anti-viral ribavirin uptake mediated by hCNT3 and hENT1 in Xenopus laevis oocytes. (PMID: 20096989) Yamamoto T. … Nakagaki T. (Biophys. Chem. 2010) 25 26
  4. A splice variant of the SLC28A3 gene encodes a novel human concentrative nucleoside transporter-3 (hCNT3) protein localized in the endoplasmic reticulum. (PMID: 18827020) Errasti-Murugarren E. … Pastor-Anglada M. (FASEB J. 2009) 3 23
  5. Adenosine deaminase 1 and concentrative nucleoside transporters 2 and 3 regulate adenosine on the apical surface of human airway epithelia: implications for inflammatory lung diseases. (PMID: 17696452) Hirsh A.J. … Picher M. (Biochemistry 2007) 3 23

Products for SLC28A3 Gene

Sources for SLC28A3 Gene

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