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Aliases for SLC28A3 Gene

Aliases for SLC28A3 Gene

  • Solute Carrier Family 28 (Concentrative Nucleoside Transporter), Member 3 2 3
  • CNT3 3 4 6
  • Solute Carrier Family 28 (Sodium-Coupled Nucleoside Transporter), Member 3 2 3
  • Concentrative Na(+)-Nucleoside Cotransporter 3 3 4
  • Concentrative Na+-Nucleoside Cotransporter 3
  • Solute Carrier Family 28 Member 3 3
  • CNT 3 4
  • HCNT3 4

External Ids for SLC28A3 Gene

Previous GeneCards Identifiers for SLC28A3 Gene

  • GC09M077936
  • GC09M078744
  • GC09M080445
  • GC09M082350
  • GC09M084122
  • GC09M086080
  • GC09M086890
  • GC09M056719

Summaries for SLC28A3 Gene

Entrez Gene Summary for SLC28A3 Gene

  • Nucleoside transporters, such as SLC28A3, regulate multiple cellular processes, including neurotransmission, vascular tone, adenosine concentration in the vicinity of cell surface receptors, and transport and metabolism of nucleoside drugs. SLC28A3 shows broad specificity for pyrimidine and purine nucleosides (Ritzel et al., 2001 [PubMed 11032837]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC28A3 Gene

SLC28A3 (Solute Carrier Family 28 (Concentrative Nucleoside Transporter), Member 3) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and One carbon pool by folate. GO annotations related to this gene include nucleoside binding and purine-specific nucleoside:sodium symporter activity. An important paralog of this gene is SLC28A2.

UniProtKB/Swiss-Prot for SLC28A3 Gene

  • Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3-azido-3-deoxythymidine (AZT), ribavirin and 3-deazauridine.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC28A3 Gene

Genomics for SLC28A3 Gene

Genomic Location for SLC28A3 Gene

Start:
84,275,457 bp from pter
End:
84,368,498 bp from pter
Size:
93,042 bases
Orientation:
Minus strand

Genomic View for SLC28A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC28A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC28A3 Gene

No data available for Regulatory Elements for SLC28A3 Gene

Proteins for SLC28A3 Gene

  • Protein details for SLC28A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAS3-S28A3_HUMAN
    Recommended name:
    Solute carrier family 28 member 3
    Protein Accession:
    Q9HAS3
    Secondary Accessions:
    • A8K9Y4
    • B1AML0
    • B2RA51
    • B4E2S8
    • F5GYE3

    Protein attributes for SLC28A3 Gene

    Size:
    691 amino acids
    Molecular mass:
    76930 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC28A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC28A3 Gene

Proteomics data for SLC28A3 Gene at MOPED

Post-translational modifications for SLC28A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC28A3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC28A3 Gene

Domains for SLC28A3 Gene

Gene Families for SLC28A3 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Suggested Antigen Peptide Sequences for SLC28A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HAS3

UniProtKB/Swiss-Prot:

S28A3_HUMAN :
  • Q9HAS3
Family:
  • Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
genes like me logo Genes that share domains with SLC28A3: view

Function for SLC28A3 Gene

Molecular function for SLC28A3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=21.6 uM for uridine {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; KM=15.4 uM for cytidine {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; KM=21.2 uM for thymidine {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; KM=15.1 uM for adenosine {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; KM=43 uM for guanosine {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; KM=52.5 uM for inosine {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; Vmax=25.8 pmol/min/mg enzyme for uridine uptake {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; Vmax=32.8 pmol/min/mg enzyme for cytidine uptake {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; Vmax=24.2 pmol/min/mg enzyme for thymidine uptake {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; Vmax=30.4 pmol/min/mg enzyme for adenosine uptake {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; Vmax=51.4 pmol/min/mg enzyme for guanosine uptake {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042}; Vmax=44.8 pmol/min/mg enzyme for inosine uptake {ECO:0000269 PubMed:11032837, ECO:0000269 PubMed:15861042};
UniProtKB/Swiss-Prot Function: Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3-azido-3-deoxythymidine (AZT), ribavirin and 3-deazauridine.
UniProtKB/Swiss-Prot Induction: Up-regulated by phorbol myristate acetate (PMA) in HL-60 cells.

Gene Ontology (GO) - Molecular Function for SLC28A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001882 nucleoside binding IEA --
GO:0005415 nucleoside:sodium symporter activity --
GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity IEA --
GO:0015390 purine-specific nucleoside:sodium symporter activity IEA --
genes like me logo Genes that share ontologies with SLC28A3: view

Phenotypes for SLC28A3 Gene

GenomeRNAi human phenotypes for SLC28A3:
genes like me logo Genes that share phenotypes with SLC28A3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC28A3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC28A3 Gene

Localization for SLC28A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC28A3 Gene

Isoform 1: Cell membrane; Multi-pass membrane protein.
Isoform 2: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC28A3 Gene COMPARTMENTS Subcellular localization image for SLC28A3 gene
Compartment Confidence
plasma membrane 4
cytosol 2
nucleus 2
lysosome 1

Gene Ontology (GO) - Cellular Components for SLC28A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with SLC28A3: view

Pathways for SLC28A3 Gene

genes like me logo Genes that share pathways with SLC28A3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for SLC28A3 Gene

Gene Ontology (GO) - Biological Process for SLC28A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006863 purine nucleobase transport IEA --
GO:0015855 pyrimidine nucleobase transport IEA --
GO:0015860 purine nucleoside transmembrane transport IEA --
GO:0015864 pyrimidine nucleoside transport IEA --
genes like me logo Genes that share ontologies with SLC28A3: view

Compounds for SLC28A3 Gene

(2) HMDB Compounds for SLC28A3 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5
Thymidine
  • 1-(2-Deoxy-b-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
50-89-5

(7) Drugbank Compounds for SLC28A3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine
  • 2'-Deoxyadenosine
58-61-7 transporter
Cladribine
  • 2-CdA
4291-63-8 transporter
Deoxythymidine
  • 2'-Deoxythymidine
50-89-5 transporter
Fludarabine
  • FAMP
75607-67-9 transporter
Gemcitabine
  • dFdC
95058-81-4 transporter substrate

(4) Novoseek inferred chemical compound relationships for SLC28A3 Gene

Compound -log(P) Hits PubMed IDs
nucleoside 80.1 13
purine 59.1 2
pyrimidine 57.4 1
gemcitabine 44.3 1

(2) PharmGKB related drug/compound annotations for SLC28A3 Gene

Drug/compound Annotation
anthracyclines and related substances CA
gemcitabine CA
genes like me logo Genes that share compounds with SLC28A3: view

Transcripts for SLC28A3 Gene

Unigene Clusters for SLC28A3 Gene

Solute carrier family 28 (sodium-coupled nucleoside transporter), member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC28A3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC28A3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19
SP1: - -
SP2:
SP3:

Relevant External Links for SLC28A3 Gene

GeneLoc Exon Structure for
SLC28A3
ECgene alternative splicing isoforms for
SLC28A3

Expression for SLC28A3 Gene

mRNA expression in normal human tissues for SLC28A3 Gene

mRNA differential expression in normal tissues according to GTEx for SLC28A3 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (7.7), Minor Salivary Gland (7.4), Breast - Mammary Tissue (7.3), Skin - Not Sun Exposed (Suprapubic) (6.4), and Pancreas (6.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC28A3 Gene

SOURCE GeneReport for Unigene cluster for SLC28A3 Gene Hs.535966

mRNA Expression by UniProt/SwissProt for SLC28A3 Gene

Q9HAS3-S28A3_HUMAN
Tissue specificity: Expressed in pancreas, bone marrow, trachea, mammary gland, liver, prostate, and regions of intestine, brain, lung, placenta, testis, kidney, and heart.
genes like me logo Genes that share expressions with SLC28A3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC28A3 Gene

Orthologs for SLC28A3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC28A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC28A3 35
  • 99.42 (n)
  • 99.13 (a)
SLC28A3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC28A3 35
  • 84.69 (n)
  • 79.71 (a)
SLC28A3 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC28A3 35
  • 85.22 (n)
  • 81.88 (a)
mouse
(Mus musculus)
Mammalia Slc28a3 35
  • 81.11 (n)
  • 78.62 (a)
Slc28a3 16
Slc28a3 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC28A3 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC28A3 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc28a3 35
  • 79.94 (n)
  • 78.48 (a)
chicken
(Gallus gallus)
Aves SLC28A3 35
  • 68.28 (n)
  • 64.85 (a)
SLC28A3 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC28A3 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc28a3 35
  • 64.34 (n)
  • 64.49 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7100 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005988 35
  • 54 (n)
  • 48.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8083 35
  • 53.38 (n)
  • 44.63 (a)
CG8083 36
  • 33 (a)
ManyToMany
CNT1 36
  • 32 (a)
ManyToMany
CG11778 37
  • 42 (a)
BEST:CK00459 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea F27E11.2 35
  • 47.7 (n)
  • 35.04 (a)
slc-28.1 36
  • 29 (a)
ManyToMany
slc-28.2 36
  • 30 (a)
ManyToMany
F27E11.1 37
  • 35 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08148 35
  • 48.7 (n)
  • 37.78 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5907 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToOne
Species with no ortholog for SLC28A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC28A3 Gene

ENSEMBL:
Gene Tree for SLC28A3 (if available)
TreeFam:
Gene Tree for SLC28A3 (if available)

Paralogs for SLC28A3 Gene

Paralogs for SLC28A3 Gene

Selected SIMAP similar genes for SLC28A3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC28A3: view

Variants for SLC28A3 Gene

Sequence variations from dbSNP and Humsavar for SLC28A3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs885003 -- 84,294,520(+) GAAGT(C/T)TGGGG intron-variant
rs885004 -- 84,294,635(+) GTTGA(A/G)ATAAA intron-variant
rs980292 -- 84,331,692(+) TGTGG(C/T)AAGAT intron-variant
rs1972245 -- 84,332,442(+) TAGGG(C/T)AGGGG intron-variant
rs3750406 -- 84,277,979(+) CAACA(A/C)CACCT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC28A3 Gene

Variant ID Type Subtype PubMed ID
nsv436717 OTHER Inversion 17901297
nsv8542 CNV Loss 18304495
esv34058 CNV Loss 18971310
nsv893518 CNV Loss 21882294
nsv893519 CNV Gain 21882294

Relevant External Links for SLC28A3 Gene

HapMap Linkage Disequilibrium report
SLC28A3
Human Gene Mutation Database (HGMD)
SLC28A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC28A3 Gene

Disorders for SLC28A3 Gene

Relevant External Links for SLC28A3

Genetic Association Database (GAD)
SLC28A3
Human Genome Epidemiology (HuGE) Navigator
SLC28A3
genes like me logo Genes that share disorders with SLC28A3: view

No data available for UniProtKB/Swiss-Prot for SLC28A3 Gene

Publications for SLC28A3 Gene

  1. Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). (PMID: 11032837) Ritzel M.W.L. … Young J.D. (J. Biol. Chem. 2001) 2 3 4 23
  2. Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3). (PMID: 15738947) Badagnani I. … Giacomini K.M. (Pharmacogenomics J. 2005) 3 4 23 25
  3. Identification and functional characterization of variants in human concentrative nucleoside transporter 3, hCNT3 (SLC28A3), arising from single nucleotide polymorphisms in coding regions of the hCNT3 gene. (PMID: 15861042) Damaraju S. … Cass C.E. (Pharmacogenet. Genomics 2005) 3 4 23
  4. A splice variant of the SLC28A3 gene encodes a novel human concentrative nucleoside transporter-3 (hCNT3) protein localized in the endoplasmic reticulum. (PMID: 18827020) Errasti-Murugarren E. … Pastor-Anglada M. (FASEB J. 2009) 3 4 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for SLC28A3 Gene

Sources for SLC28A3 Gene

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