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Aliases for SLC28A2 Gene

Aliases for SLC28A2 Gene

  • Solute Carrier Family 28 Member 2 2 3 4 5
  • Solute Carrier Family 28 (Sodium-Coupled Nucleoside Transporter), Member 2 2 3
  • Solute Carrier Family 28 (Concentrative Nucleoside Transporter), Member 2 2 3
  • Sodium-Coupled Nucleoside Transporter 2 3 4
  • Sodium/Purine Nucleoside Co-Transporter 3 4
  • Concentrative Nucleoside Transporter 2 3 4
  • Na(+)/Nucleoside Cotransporter 2 3 4
  • CNT 2 3 4
  • HCNT2 3 4
  • CNT2 3 4
  • SPNT 3 4
  • Sodium/Nucleoside Cotransporter 2 3
  • HsT17153 3
  • SPNT1 3

External Ids for SLC28A2 Gene

Previous GeneCards Identifiers for SLC28A2 Gene

  • GC15P041102
  • GC15P038591
  • GC15P043123
  • GC15P043260
  • GC15P043331
  • GC15P045544
  • GC15P022369

Summaries for SLC28A2 Gene

GeneCards Summary for SLC28A2 Gene

SLC28A2 (Solute Carrier Family 28 Member 2) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics. GO annotations related to this gene include nucleoside binding and purine nucleoside transmembrane transporter activity. An important paralog of this gene is SLC28A1.

UniProtKB/Swiss-Prot for SLC28A2 Gene

  • Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues.

Gene Wiki entry for SLC28A2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC28A2 Gene

Genomics for SLC28A2 Gene

Regulatory Elements for SLC28A2 Gene

Enhancers for SLC28A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G045161 1.4 Ensembl ENCODE dbSUPER 10.9 -89.2 -89173 1.8 HDGF RB1 ARNT ARID4B RAD21 RFX5 SCRT2 ZNF143 ZNF207 FOS DUOXA1 ENSG00000259539 SHF DUOX1 SLC28A2 DUOX2 PIR61454 GC15P045136 GC15P045137 GC15P045138
GH15G045165 1.3 ENCODE dbSUPER 10.9 -84.2 -84215 4.7 HDGF PKNOX1 ARNT WRNIP1 SIN3A FEZF1 YBX1 YY1 ZNF766 ZNF207 DUOXA1 ENSG00000259539 SHF DUOX1 SLC28A2 DUOX2 ENSG00000259519
GH15G045197 1.4 ENCODE dbSUPER 9.8 -52.1 -52141 4.3 MLX CREB3L1 DMAP1 YY1 ZNF143 ZNF263 NFYC TBX21 MEF2D SSRP1 CTDSPL2 ENSG00000259563 EIF3J-AS1 HNRNPMP1 DUOX1 ENSG00000259539 BLOC1S6 SLC28A2 LOC101928414 DUOX2
GH15G045156 1.3 Ensembl ENCODE dbSUPER 10.2 -94.3 -94313 2.0 KLF1 ZBTB21 JUN KLF17 CEBPG KAT2B FOSL1 ZNF324 ZNF600 KLF8 DUOXA1 ENSG00000259539 DUOX1 SHF SPATA5L1 SLC28A2 C15orf48 GC15P045138 GC15P045137 GC15P045136
GH15G045385 1.2 ENCODE dbSUPER 10.5 +135.1 135058 2.6 FOXA2 ATF1 MLX ARID4B FEZF1 YY1 TSHZ1 MIER2 PPARG KAT8 SPATA5L1 LOC100533853 SLC28A2 DUOXA1 DUOX1 PIR55932
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC28A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC28A2 Gene

Chromosome:
15
Start:
45,252,066 bp from pter
End:
45,277,845 bp from pter
Size:
25,780 bases
Orientation:
Plus strand

Genomic View for SLC28A2 Gene

Genes around SLC28A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC28A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC28A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC28A2 Gene

Proteins for SLC28A2 Gene

  • Protein details for SLC28A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43868-S28A2_HUMAN
    Recommended name:
    Sodium/nucleoside cotransporter 2
    Protein Accession:
    O43868
    Secondary Accessions:
    • A8K7F9
    • O43239
    • Q52LZ0

    Protein attributes for SLC28A2 Gene

    Size:
    658 amino acids
    Molecular mass:
    71926 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC28A2 Gene

Post-translational modifications for SLC28A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC28A2 Gene

No data available for DME Specific Peptides for SLC28A2 Gene

Domains & Families for SLC28A2 Gene

Gene Families for SLC28A2 Gene

HGNC:
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

O43868

UniProtKB/Swiss-Prot:

S28A2_HUMAN :
  • Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
Family:
  • Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
genes like me logo Genes that share domains with SLC28A2: view

Function for SLC28A2 Gene

Molecular function for SLC28A2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by formycin B.
UniProtKB/Swiss-Prot Function:
Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues.

Gene Ontology (GO) - Molecular Function for SLC28A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005415 nucleoside:sodium symporter activity IEA,TAS --
GO:0015211 purine nucleoside transmembrane transporter activity TAS 9435697
genes like me logo Genes that share ontologies with SLC28A2: view
genes like me logo Genes that share phenotypes with SLC28A2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC28A2

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC28A2 Gene

Localization for SLC28A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC28A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC28A2 gene
Compartment Confidence
plasma membrane 5
extracellular 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC28A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA,IEA --
GO:0016020 membrane TAS,IEA 9435697
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC28A2: view

Pathways & Interactions for SLC28A2 Gene

genes like me logo Genes that share pathways with SLC28A2: view

Interacting Proteins for SLC28A2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000315006%0d%0a9606.ENSP00000356505%0d%0a
Selected Interacting proteins: ENSP00000315006 O43868-S28A2_HUMAN for SLC28A2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLC28A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 9435697
GO:0006810 transport IEA --
GO:0015860 purine nucleoside transmembrane transport TAS 9435697
GO:1901642 nucleoside transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC28A2: view

No data available for SIGNOR curated interactions for SLC28A2 Gene

Drugs & Compounds for SLC28A2 Gene

(15) Drugs for SLC28A2 Gene - From: DrugBank, PharmGKB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 2018
Ribavirin Approved Pharma 1003
Mercaptopurine Approved Pharma Transporter, substrate 0
Peginterferon alfa-2b Approved Pharma 307
protease inhibitors Pharma 5471

(9) Additional Compounds for SLC28A2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC28A2: view

Transcripts for SLC28A2 Gene

mRNA/cDNA for SLC28A2 Gene

Unigene Clusters for SLC28A2 Gene

Solute carrier family 28 (sodium-coupled nucleoside transporter), member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC28A2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: -
SP2: -

Relevant External Links for SLC28A2 Gene

GeneLoc Exon Structure for
SLC28A2
ECgene alternative splicing isoforms for
SLC28A2

Expression for SLC28A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC28A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC28A2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x22.3), Colon - Transverse (x10.5), and Stomach (x8.4).

Protein differential expression in normal tissues from HIPED for SLC28A2 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC28A2 Gene



Protein tissue co-expression partners for SLC28A2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC28A2 Gene:

SLC28A2

SOURCE GeneReport for Unigene cluster for SLC28A2 Gene:

Hs.367833

mRNA Expression by UniProt/SwissProt for SLC28A2 Gene:

O43868-S28A2_HUMAN
Tissue specificity: Expressed in heart and skeletal muscle followed by liver, kidney, intestine, pancreas, placenta and brain. Weak expression in lung.

Evidence on tissue expression from TISSUES for SLC28A2 Gene

  • Intestine(4.4)
  • Kidney(4.3)
genes like me logo Genes that share expression patterns with SLC28A2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC28A2 Gene

Orthologs for SLC28A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC28A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC28A2 34 35
  • 99.39 (n)
cow
(Bos Taurus)
Mammalia SLC28A2 34 35
  • 88.84 (n)
mouse
(Mus musculus)
Mammalia Slc28a2 34 16 35
  • 82.98 (n)
Gm14085 35
  • 76 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slc28a2 34
  • 82.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 71 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia SLC28A2 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC28A2 34
  • 65.33 (n)
-- 35
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 52 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc28a2 34
  • 63.52 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-24l11.1 34
  • 59.52 (n)
SLC28A2 35
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CNT1 34 35
  • 50.72 (n)
BEST:CK00459 36
  • 45 (a)
CG11778 36
  • 45 (a)
CG8083 35
  • 35 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F27E11.1 36
  • 31 (a)
slc-28.1 35
  • 28 (a)
ManyToMany
slc-28.2 35
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
Species where no ortholog for SLC28A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC28A2 Gene

ENSEMBL:
Gene Tree for SLC28A2 (if available)
TreeFam:
Gene Tree for SLC28A2 (if available)

Paralogs for SLC28A2 Gene

Paralogs for SLC28A2 Gene

(2) SIMAP similar genes for SLC28A2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC28A2: view

Variants for SLC28A2 Gene

Sequence variations from dbSNP and Humsavar for SLC28A2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000224601 -- 45,262,416(+) GCCTT(C/G)ATGAC intron-variant
rs1000225543 -- 45,259,410(+) AAGTG(A/G)TCCTC intron-variant
rs1000266068 -- 45,256,094(+) ATATA(C/T)AACAT intron-variant
rs1000328976 -- 45,263,217(+) TGAAA(A/G)CTCCC intron-variant, reference, missense
rs1000581802 -- 45,260,407(+) AAGGC(C/T)AGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC28A2 Gene

Variant ID Type Subtype PubMed ID
esv3636336 CNV gain 21293372
esv3636337 CNV gain 21293372
nsv569315 CNV gain 21841781

Variation tolerance for SLC28A2 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.46; 92.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC28A2 Gene

Human Gene Mutation Database (HGMD)
SLC28A2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC28A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC28A2 Gene

Disorders for SLC28A2 Gene

Relevant External Links for SLC28A2

Genetic Association Database (GAD)
SLC28A2
Human Genome Epidemiology (HuGE) Navigator
SLC28A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC28A2

No disorders were found for SLC28A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC28A2 Gene

Publications for SLC28A2 Gene

  1. Na+-dependent purine nucleoside transporter from human kidney: cloning and functional characterization. (PMID: 9435697) Wang J. … Giacomini K.M. (Am. J. Physiol. 1997) 2 3 4 22 64
  2. Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians. (PMID: 17700367) Li L. … Lee E.J.D. (Pharmacogenet. Genomics 2007) 3 4 22 64
  3. Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2. (PMID: 15861032) Owen R.P. … Giacomini K.M. (Pharmacogenet. Genomics 2005) 3 4 22 64
  4. Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2. (PMID: 10455109) Loewen S.K. … Young J.D. (J. Biol. Chem. 1999) 3 4 22 64
  5. Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. (PMID: 10087507) Ritzel M.W.L. … Young J.D. (Mol. Membr. Biol. 1998) 3 4 22 64

Products for SLC28A2 Gene

Sources for SLC28A2 Gene

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