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Aliases for SLC28A2 Gene

Aliases for SLC28A2 Gene

  • Solute Carrier Family 28 Member 2 2 3 4
  • Solute Carrier Family 28 (Concentrative Nucleoside Transporter), Member 2 2 3 5
  • Solute Carrier Family 28 (Sodium-Coupled Nucleoside Transporter), Member 2 2 3
  • Sodium-Coupled Nucleoside Transporter 2 3 4
  • Sodium/Purine Nucleoside Co-Transporter 3 4
  • Concentrative Nucleoside Transporter 2 3 4
  • Na(+)/Nucleoside Cotransporter 2 3 4
  • CNT 2 3 4
  • HCNT2 3 4
  • CNT2 3 4
  • SPNT 3 4
  • HsT17153 3
  • SPNT1 3

External Ids for SLC28A2 Gene

Previous GeneCards Identifiers for SLC28A2 Gene

  • GC15P041102
  • GC15P038591
  • GC15P043123
  • GC15P043260
  • GC15P043331
  • GC15P045544
  • GC15P022369

Summaries for SLC28A2 Gene

GeneCards Summary for SLC28A2 Gene

SLC28A2 (Solute Carrier Family 28 Member 2) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and One carbon pool by folate. GO annotations related to this gene include nucleoside binding and purine nucleoside transmembrane transporter activity. An important paralog of this gene is SLC28A3.

UniProtKB/Swiss-Prot for SLC28A2 Gene

  • Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues.

Gene Wiki entry for SLC28A2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC28A2 Gene

Genomics for SLC28A2 Gene

Regulatory Elements for SLC28A2 Gene

Genomic Location for SLC28A2 Gene

Chromosome:
15
Start:
45,252,066 bp from pter
End:
45,277,845 bp from pter
Size:
25,780 bases
Orientation:
Plus strand

Genomic View for SLC28A2 Gene

Genes around SLC28A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC28A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC28A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC28A2 Gene

Proteins for SLC28A2 Gene

  • Protein details for SLC28A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43868-S28A2_HUMAN
    Recommended name:
    Sodium/nucleoside cotransporter 2
    Protein Accession:
    O43868
    Secondary Accessions:
    • A8K7F9
    • O43239
    • Q52LZ0

    Protein attributes for SLC28A2 Gene

    Size:
    658 amino acids
    Molecular mass:
    71926 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC28A2 Gene

Proteomics data for SLC28A2 Gene at MOPED

Post-translational modifications for SLC28A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC28A2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC28A2 Gene

Domains & Families for SLC28A2 Gene

Gene Families for SLC28A2 Gene

HGNC:
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

O43868

UniProtKB/Swiss-Prot:

S28A2_HUMAN :
  • Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
Family:
  • Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
genes like me logo Genes that share domains with SLC28A2: view

Function for SLC28A2 Gene

Molecular function for SLC28A2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by formycin B.
UniProtKB/Swiss-Prot Function:
Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues.
genes like me logo Genes that share phenotypes with SLC28A2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC28A2 Gene

Localization for SLC28A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC28A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC28A2 Gene COMPARTMENTS Subcellular localization image for SLC28A2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC28A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,TAS 9435697
genes like me logo Genes that share ontologies with SLC28A2: view

Pathways & Interactions for SLC28A2 Gene

genes like me logo Genes that share pathways with SLC28A2: view

Interacting Proteins for SLC28A2 Gene

Gene Ontology (GO) - Biological Process for SLC28A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015860 purine nucleoside transmembrane transport TAS 9435697
genes like me logo Genes that share ontologies with SLC28A2: view

No data available for SIGNOR curated interactions for SLC28A2 Gene

Drugs & Compounds for SLC28A2 Gene

(13) Drugs for SLC28A2 Gene - From: Novoseek, PharmGKB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1881
Mercaptopurine Approved Pharma Transporter, substrate 0

(9) Additional Compounds for SLC28A2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC28A2: view

Transcripts for SLC28A2 Gene

mRNA/cDNA for SLC28A2 Gene

Unigene Clusters for SLC28A2 Gene

Solute carrier family 28 (sodium-coupled nucleoside transporter), member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC28A2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: -
SP2: -

Relevant External Links for SLC28A2 Gene

GeneLoc Exon Structure for
SLC28A2
ECgene alternative splicing isoforms for
SLC28A2

Expression for SLC28A2 Gene

mRNA expression in normal human tissues for SLC28A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC28A2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x22.3), Colon - Transverse (x10.5), and Stomach (x8.4).

Protein differential expression in normal tissues from HIPED for SLC28A2 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC28A2 Gene



SOURCE GeneReport for Unigene cluster for SLC28A2 Gene Hs.367833

mRNA Expression by UniProt/SwissProt for SLC28A2 Gene

O43868-S28A2_HUMAN
Tissue specificity: Expressed in heart and skeletal muscle followed by liver, kidney, intestine, pancreas, placenta and brain. Weak expression in lung.
genes like me logo Genes that share expression patterns with SLC28A2: view

Protein tissue co-expression partners for SLC28A2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SLC28A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC28A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC28A2 36
  • 99 (a)
OneToOne
SLC28A2 35
  • 99.39 (n)
  • 99.09 (a)
cow
(Bos Taurus)
Mammalia SLC28A2 35
  • 88.84 (n)
  • 85.84 (a)
SLC28A2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm14085 36
  • 76 (a)
OneToMany
Slc28a2 36
  • 80 (a)
OneToMany
Slc28a2 16
Slc28a2 35
  • 82.98 (n)
  • 80.4 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC28A2 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Slc28a2 35
  • 82.78 (n)
  • 81 (a)
chicken
(Gallus gallus)
Aves SLC28A2 35
  • 65.33 (n)
  • 60.22 (a)
-- 36
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc28a2 35
  • 63.52 (n)
  • 62.63 (a)
zebrafish
(Danio rerio)
Actinopterygii SLC28A2 36
  • 52 (a)
OneToMany
si:dkey-24l11.1 35
  • 59.52 (n)
  • 56.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8083 36
  • 35 (a)
ManyToMany
CNT1 36
  • 34 (a)
ManyToMany
CNT1 35
  • 50.72 (n)
  • 43.48 (a)
BEST:CK00459 37
  • 45 (a)
CG11778 37
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea F27E11.1 37
  • 31 (a)
slc-28.1 36
  • 28 (a)
ManyToMany
slc-28.2 36
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
Species with no ortholog for SLC28A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC28A2 Gene

ENSEMBL:
Gene Tree for SLC28A2 (if available)
TreeFam:
Gene Tree for SLC28A2 (if available)

Paralogs for SLC28A2 Gene

Paralogs for SLC28A2 Gene

(2) SIMAP similar genes for SLC28A2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC28A2: view

Variants for SLC28A2 Gene

Sequence variations from dbSNP and Humsavar for SLC28A2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_022001 -
VAR_024639 -
VAR_024640 -
VAR_024641 -
VAR_024642 -

Variation tolerance for SLC28A2 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.46; 92.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC28A2 Gene

HapMap Linkage Disequilibrium report
SLC28A2
Human Gene Mutation Database (HGMD)
SLC28A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC28A2 Gene

Disorders for SLC28A2 Gene

Relevant External Links for SLC28A2

Genetic Association Database (GAD)
SLC28A2
Human Genome Epidemiology (HuGE) Navigator
SLC28A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC28A2

No disorders were found for SLC28A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC28A2 Gene

Publications for SLC28A2 Gene

  1. Na+-dependent purine nucleoside transporter from human kidney: cloning and functional characterization. (PMID: 9435697) Wang J. … Giacomini K.M. (Am. J. Physiol. 1997) 2 3 4 23 67
  2. Identification and characterization of proximal promoter polymorphisms in the human concentrative nucleoside transporter 2 (SLC28A2). (PMID: 19098160) Yee S.W. … Giacomini K.M. (J. Pharmacol. Exp. Ther. 2009) 3 23
  3. Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes. (PMID: 18635603) Govindarajan R. … Unadkat J.D. (Am. J. Physiol. Gastrointest. Liver Physiol. 2008) 3 23
  4. Adenosine deaminase 1 and concentrative nucleoside transporters 2 and 3 regulate adenosine on the apical surface of human airway epithelia: implications for inflammatory lung diseases. (PMID: 17696452) Hirsh A.J. … Picher M. (Biochemistry 2007) 3 23
  5. Altered expression of nucleoside transporter genes (SLC28 and SLC29) in adipose tissue from HIV-1-infected patients. (PMID: 17926640) Guallar J.P. … Pastor-Anglada M. (Antivir. Ther. (Lond.) 2007) 3 23

Products for SLC28A2 Gene

Sources for SLC28A2 Gene

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