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GIFtS
-

SLC28A2 Gene

protein-coding GIFtS: 55
GCID: GC15P045544

solute carrier family 28 (sodium-coupled nucleoside transporter),...

Explore 8 diseases affiliated with
SLC28A2 via

MalaCards

our new
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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 28 (Sodium-Coupled Nucleoside Transporter), Member 2¹ ²		Sodium/Purine Nucleoside Co-Transporter² ³
CNT2¹ ² ³ ⁵		Solute Carrier Family 28 Member 2² ³
SPNT1¹ ² ⁵		SPNT² ³
HCNT2¹ ²		CNT 2² ³
HsT17153¹ ²		Na(+)/Nucleoside Cotransporter 2² ³
Concentrative Nucleoside Transporter 2² ³		Sodium/Nucleoside Cotransporter 2²
Sodium-Coupled Nucleoside Transporter 2² ³		HCNT2¹ ²

External Ids:	HGNC: 11002¹	Entrez Gene: 9153²	Ensembl: ENSG00000137860⁷	OMIM: 606208⁵	UniProtKB: O43868³

Export aliases for SLC28A2 gene to outside databases

Previous GC identifers: GC15P041102 GC15P038591 GC15P043123 GC15P043260 GC15P043331 GC15P022369

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: S28A2_HUMAN, O43868

Function: Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside

transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in

specific uptake and salvage of purine nucleosides in kidney and other tissues

Gene Wiki entry for SLC28A2 (Concentrative nucleoside transporter 2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC28A2 gene promoter:
AP-2rep ER-alpha STAT1 C/EBPbeta STAT1beta STAT1alpha c-Rel SEF-1 (1)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC28A2 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC28A2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC28A2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15 Ensembl cytogenetic band: 15q21.1 HGNC cytogenetic band: 15q15

SLC28A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC28A2 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P045544: view genomic region (about GC identifiers)

Start:	45,544,428 bp from pter	End:	45,568,149 bp from pter
Size:	23,722 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S28A2_HUMAN, O43868 (See protein sequence)

Recommended Name: Sodium/nucleoside cotransporter 2

Size: 658 amino acids; 71926 Da

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: A8K7F9 O43239 Q52LZ0

Explore the universe of human proteins at neXtProt for SLC28A2: NX_O43868

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O43868

SLC28A2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004203.2

ENSEMBL proteins:

ENSP00000315006 ENSP00000454074 ENSP00000454046

Reactome Protein details: O43868
Human Recombinant Protein Products:

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	Uscn Proteins for SLC28A2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	9435697
GO:0016020	membrane	TAS	9435697

SLC28A2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC28A2 for domains About GeneDecksing

5 InterPro domains/families:

IPR018270 C_nuclsd_transpt_met_bac

IPR008276 C_nuclsd_transpt

IPR002668 Nuclsd_transpt2

IPR011642 Nucleoside_recog_Gate

IPR011657 Nucleos_tra2_C

Graphical View of Domain Structure for InterPro Entry O43868

ProtoNet protein and cluster: O43868

2 Blocks protein families:

IPB002668 Na+ dependent nucleoside transporter

IPB011642 Nucleoside recognition

UniProtKB/Swiss-Prot: S28A2_HUMAN, O43868

Similarity: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: S28A2_HUMAN, O43868

Function: Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside

transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in

specific uptake and salvage of purine nucleosides in kidney and other tissues

Enzyme regulation: Inhibited by formycin B

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC28A2
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC28A2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001882	nucleoside binding	IEA	--
GO:0005415	nucleoside:sodium symporter activity	IEA	--
GO:0015211	purine nucleoside transmembrane transporter activity	TAS	9435697

SLC28A2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SLC28A2:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

SLC-mediated transmembrane transport

SLC-mediated transmembrane transport

1.00

Transmembrane transport of small molecules

0.50

Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

1.00

Antimetabolite Pathway - Folate Cycle, Pharmacodynamics

Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

0.36

Transport of organic anions

Transport of vitamins, nucleosides, and related molecules

0.35

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for SLC28A2

	SLC-mediated transmembrane transport
	Transmembrane transport of small molecules
	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
	Transport of vitamins, nucleosides, and related molecules

1 PharmGKB Pathway for SLC28A2

Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

SLC28A2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLC28A2

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006139	nucleobase-containing compound metabolic process	TAS	9435697
GO:0015860	purine nucleoside transmembrane transport	TAS	9435697
GO:0055085	transmembrane transport	TAS	--

SLC28A2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SLC28A2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC28A2

1 HMDB Compound for SLC28A2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Sodium	Sodium (see all 2)	7440-23-5	--

10/20 Novoseek chemical compound relationships for SLC28A2 gene (see all 20) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
nucleoside	88	106	12893280 (3), 18371949 (3), 15861032 (3), 16840788 (2) (see all 32)
pyrimidine nucleoside	78.5	4	18371949 (1), 11641443 (1), 12856181 (1)
uridine	78.4	17	15044622 (3), 10087507 (3), 11641443 (2), 12893280 (1) (see all 6)
purine nucleoside	78.3	5	18371949 (1), 10455109 (1), 12856181 (1), 10087507 (1)
inosine	78.3	4	18371949 (1), 9435697 (1)
5-fluorouridine	72.2	2	15044622 (1)
fudr	68.1	6	16462026 (2), 12893280 (1), 15044622 (1)
purine	67.8	5	15870078 (1), 11641443 (1), 12856181 (1), 11156184 (1)
2-chlorodeoxyadenosine	64.9	14	16840788 (4), 15044622 (1)
pyrimidine	62.7	7	12856181 (2), 19380585 (1), 10455109 (1), 18668436 (1)

Search CenterWatch for drugs/clinical trials and news about SLC28A2 / S28A2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC28A2 gene:

NM_004212.3

Unigene Cluster for SLC28A2:

Solute carrier family 28 (sodium-coupled nucleoside transporter), member 2

Hs.367833 [show with all ESTs]

Unigene Representative Sequence: NM_004212

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000347644(uc001zva.2) ENST00000560438 ENST00000559924 ENST00000560767

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Additional cDNA sequence:

AF036109.1 AK222709.1 AK291974.1 BC093737.1 BC112047.1 U84392.1

3 DOTS entries:

DT.405169 DT.75185178 DT.92015193

13 AceView cDNA sequences:

AK025121 AW351757 AF036109 AU076734 U84392 AA377292 NM_004212 AI913711

AA358822 BX107764 BG199614 AU099677 BG006167

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC28A2 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	·	10c	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18
SP1:																			-
SP2:											-

ECgene alternative splicing isoforms for SLC28A2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC28A2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTGCAGAG

About this image

SLC28A2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Gut Tube

Midgut

Gut Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLC28A2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC28A2

SOURCE GeneReport for Unigene cluster: Hs.367833

UniProtKB/Swiss-Prot: S28A2_HUMAN, O43868

Tissue specificity: Expressed in heart and skeletal muscle followed by liver, kidney, intestine, pancreas, placenta and

brain. Weak expression in lung

SABiosciences Expression via Pathway-Focused PCR Array including SLC28A2:

Drug Transporters in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for SLC28A2 gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLC28A2¹	solute carrier family 28 (sodium-coupled nucleoside more	65.48(n) 60.09(a)		415338 XM_413724.3 XP_413724.2
lizard (Anolis carolinensis)	Reptilia	--	--	53(a)	1 → many	GL343490.1(97432-105828)
zebrafish (Danio rerio)	Actinopterygii	si:dkey-24l11.1⁶	si:dkey-24l11.1	52(a)	1 → many	18(26773453-26795881)
fruit fly (Drosophila melanogaster)	Insecta	CG11778^{1 , 3}	nucleoside:sodium symporter³ CG11778¹	45(a) (best of 2)³ 50.25(n)¹ 41.47(a)¹		45A1³ 35915¹ NM_136603.2¹ NP_610447.2¹
worm (Caenorhabditis elegans)	Secernentea	F27E11.1³	nucleoside transporter	31(a)		V(3463660-3465965) --
E. coli (Escherichia coli)	Gamma proteobacteria	nupX⁶ psuT⁶ (see all 3)	predicted nucleoside transporter (see all 3)	30(a) 29(a) (see all 3)	many ↔ many many ↔ many (see all 3)	Chromosome(2250917-2252167) Chromosome(2254107-2255357)

ENSEMBL Gene Tree for SLC28A2 (if available)
TreeFam Gene Tree for SLC28A2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC28A2 gene

SLC28A1² SLC28A3²

2 SIMAP similar genes for SLC28A2 using alignment to 4 protein entries: S28A2_HUMAN (see all proteins):

SLC28A1 SLC28A3

SLC28A2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2899377^1,2	C,F,O,A,H,	--	45542643(-)	`TCCAAT/ACACCA`	1	--	us2k¹		18		NS EA NA WA CSA	812
rs3759892^1,2	C,F,A,H,	--	45542709(+)	`TTCACA/GTATTT`	1	--	us2k¹ tfbs³		13		NS EA NA WA CSA	788
rs8039610^1,2	C,H,	--	45542739(+)	`cctaaT/Aaatat`	1	--	us2k¹ tfbs³		4		NS EA	418
rs190978348^1,2		--	45542924(+)	`AAATTA/TAAAAA`	1	--	us2k¹		0	--	--	--	--
rs3759893^1,2	C,F,	--	45542950(+)	`TGGTGG/TTACAC`	1	--	us2k¹		11		NA WA CSA EA	373
rs200056072^1,2	C,	--	45543101(+)	`AAAAA-/AGAC AGAGA`	1	--	us2k¹		0	--	--	--	--
rs79041435^1,2	C	--	45543102(+)	`AAAAAG/AACAGA`	1	--	us2k¹		1		WA	2
rs77799432^1,2	C,	--	45543104(+)	`AAAGAC/AAGAGA`	1	--	us2k¹		1		WA	2
rs182812103^1,2		--	45543203(+)	`AGGGGA/TCCTAA`	1	--	us2k¹		0	--	--	--	--
rs146406526^1,2		--	45543248(+)	`TCTTTC/TTTTCC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SLC28A2 (45544428 - 45568149 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC28A2: --
Human Gene Mutation Database (HGMD): SLC28A2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC28A2

DNA2.0 Custom Variant and Variant Library Synthesis for SLC28A2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC28A2 for disorders           About GeneDecksing

OMIM gene information: 606208    OMIM disorders: --

8 diseases for SLC28A2:    About MalaCards

inflammatory bowel disease chronic lymphocytic leukemia lymphocytic leukemia choriocarcinoma

leukemia choroiditis pancreatic cancer pancreatitis

1 Novoseek disease relationship for SLC28A2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia	21.4	2	11641443 (1)

Human Genome Epidemiology (HuGE) Navigator: SLC28A2 (6 documents)

Export disorders for SLC28A2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SLC28A2 gene, integrated from 9 sources (see all 62):
(articles sorted by number of sources associating them with SLC28A2)

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Na+-dependent purine nucleoside transporter from human kidney: cloning and functional characterization. (PubMed id 9435697)^{1, 2, 3, 9} Wang J....Giacomini K.M. (1997)
Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians. (PubMed id 17700367)^{1, 2, 9} Li L.... Lee E.J.D. (2007)
Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2. (PubMed id 15861032)^{1, 2, 9} Owen R.P.... Giacomini K.M. (2005)
Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. (PubMed id 10087507)^{1, 2, 9} Ritzel M.W.L....Young J.D. (1998)
Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2. (PubMed id 10455109)^{1, 2, 9} Loewen S.K....Young J.D. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter, CNT2. (PubMed id 16840788)^{1, 9} Owen R.P....Giacomini K.M. (2006)
Identification and characterization of proximal promoter polymorphisms in the human concentrative nucleoside transporter 2 (SLC28A2). (PubMed id 19098160)^{1, 9} Yee S.W....Giacomini K.M. (2009)
Functional expression and characterization of a sodium-dependent nucleoside transporter hCNT2 cloned from human duodenum. (PubMed id 12893280)^{1, 9} Shin H.C....Amidon G.L. (2003)
Interactions of nucleoside analogs, caffeine, and nicotine with human concentrative nucleoside transporters 1 and 2 stably produced in a transport-defective human cell line. (PubMed id 15044622)^{1, 9} Lang T.T....Cass C.E. (2004)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9153	HGNC: 11002	AceView: SLC28A2	Ensembl:ENSG00000137860	euGenes: HUgn9153
ECgene: SLC28A2	H-InvDB: SLC28A2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SLC28A2	Pharmacogenomics, SNPs, Pathways

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SLC28A2 Gene

solute carrier family 28 (sodium-coupled nucleoside transporter),...

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