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Aliases for SLC28A2 Gene

Aliases for SLC28A2 Gene

  • Solute Carrier Family 28 (Concentrative Nucleoside Transporter), Member 2 2 3
  • CNT2 3 4 6
  • Solute Carrier Family 28 (Sodium-Coupled Nucleoside Transporter), Member 2 2 3
  • Sodium-Coupled Nucleoside Transporter 2 3 4
  • Sodium/Purine Nucleoside Co-Transporter 3 4
  • Concentrative Nucleoside Transporter 2 3 4
  • Solute Carrier Family 28 Member 2 3 4
  • Na(+)/Nucleoside Cotransporter 2 3 4
  • CNT 2 3 4
  • HCNT2 3 4
  • SPNT1 3 6
  • SPNT 3 4
  • Sodium/Nucleoside Cotransporter 2 3
  • HsT17153 3

External Ids for SLC28A2 Gene

Summaries for SLC28A2 Gene

GeneCards Summary for SLC28A2 Gene

SLC28A2 (Solute Carrier Family 28 (Concentrative Nucleoside Transporter), Member 2) is a Protein Coding gene. Diseases associated with SLC28A2 include chronic lymphocytic leukemia. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and One carbon pool by folate. GO annotations related to this gene include nucleoside binding and purine nucleoside transmembrane transporter activity. An important paralog of this gene is SLC28A3.

UniProtKB/Swiss-Prot for SLC28A2 Gene

  • Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues

Gene Wiki entry for SLC28A2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC28A2 Gene

Genomics for SLC28A2 Gene

Genomic Location for SLC28A2 Gene

Start:
45,252,230 bp from pter
End:
45,277,845 bp from pter
Size:
25,616 bases
Orientation:
Plus strand

Genomic View for SLC28A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC28A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC28A2 Gene

Regulatory Elements for SLC28A2 Gene

Proteins for SLC28A2 Gene

  • Protein details for SLC28A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43868-S28A2_HUMAN
    Recommended name:
    Sodium/nucleoside cotransporter 2
    Protein Accession:
    O43868
    Secondary Accessions:
    • A8K7F9
    • O43239
    • Q52LZ0

    Protein attributes for SLC28A2 Gene

    Size:
    658 amino acids
    Molecular mass:
    71926 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC28A2 Gene

Proteomics data for SLC28A2 Gene at MOPED

Post-translational modifications for SLC28A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC28A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC28A2 Gene

Domains for SLC28A2 Gene

Gene Families for SLC28A2 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

UniProtKB/Swiss-Prot:

S28A2_HUMAN
Family:
  • Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.:
    • O43868
genes like me logo Genes that share domains with SLC28A2: view

Function for SLC28A2 Gene

Molecular function for SLC28A2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by formycin B
UniProtKB/Swiss-Prot Function: Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues

Gene Ontology (GO) - Molecular Function for SLC28A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001882 nucleoside binding IEA --
GO:0005415 nucleoside:sodium symporter activity IEA --
GO:0015211 purine nucleoside transmembrane transporter activity TAS 9435697
genes like me logo Genes that share ontologies with SLC28A2: view

Phenotypes for SLC28A2 Gene

GenomeRNAi human phenotypes for SLC28A2:
genes like me logo Genes that share phenotypes with SLC28A2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC28A2 Gene

Localization for SLC28A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC28A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC28A2 Gene COMPARTMENTS Subcellular localization image for SLC28A2 gene
Compartment Confidence
plasma membrane 4
cytosol 1
endoplasmic reticulum 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC28A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane TAS 9435697
genes like me logo Genes that share ontologies with SLC28A2: view

Pathways for SLC28A2 Gene

genes like me logo Genes that share pathways with SLC28A2: view

Interacting Proteins for SLC28A2 Gene

Gene Ontology (GO) - Biological Process for SLC28A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 9435697
GO:0006810 transport --
GO:0015860 purine nucleoside transmembrane transport TAS 9435697
GO:0055085 transmembrane transport TAS --
GO:1901642 nucleoside transmembrane transport --
genes like me logo Genes that share ontologies with SLC28A2: view

Compounds for SLC28A2 Gene

(1) HMDB Compounds for SLC28A2 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5

(20) Novoseek inferred chemical compound relationships for SLC28A2 Gene

Compound -log(P) Hits PubMed IDs
nucleoside 88 44
pyrimidine nucleoside 78.5 3
uridine 78.4 11
purine nucleoside 78.3 4
inosine 78.3 2
genes like me logo Genes that share compounds with SLC28A2: view

Transcripts for SLC28A2 Gene

mRNA/cDNA for SLC28A2 Gene

Unigene Clusters for SLC28A2 Gene

Solute carrier family 28 (sodium-coupled nucleoside transporter), member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC28A2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: -
SP2: -

Relevant External Links for SLC28A2 Gene

GeneLoc Exon Structure for
SLC28A2
ECgene alternative splicing isoforms for
SLC28A2

Expression for SLC28A2 Gene

mRNA expression in normal human tissues for SLC28A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC28A2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (22.3), Colon - Transverse (10.5), and Stomach (8.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC28A2 Gene

SOURCE GeneReport for Unigene cluster for SLC28A2 Gene Hs.367833

mRNA Expression by UniProt/SwissProt for SLC28A2 Gene

O43868-S28A2_HUMAN
Tissue specificity: Expressed in heart and skeletal muscle followed by liver, kidney, intestine, pancreas, placenta and brain. Weak expression in lung
genes like me logo Genes that share expressions with SLC28A2: view

Orthologs for SLC28A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC28A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC28A2 36
  • 99.39 (n)
  • 99.09 (a)
SLC28A2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC28A2 36
  • 88.84 (n)
  • 85.84 (a)
SLC28A2 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm14085 37
  • 76 (a)
OneToMany
Slc28a2 36
  • 82.98 (n)
  • 80.4 (a)
Slc28a2 16
Slc28a2 37
  • 80 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SLC28A2 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 65 (a)
ManyToMany
-- 37
  • 71 (a)
ManyToMany
-- 37
  • 22 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Slc28a2 36
  • 82.78 (n)
  • 81 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 58 (a)
OneToMany
SLC28A2 36
  • 65.33 (n)
  • 60.22 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 52 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc28a2 36
  • 63.52 (n)
  • 62.63 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-24l11.1 36
  • 59.52 (n)
  • 56.1 (a)
SLC28A2 37
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8083 37
  • 35 (a)
ManyToMany
CNT1 36
  • 50.72 (n)
  • 43.48 (a)
CNT1 37
  • 34 (a)
ManyToMany
CG11778 38
  • 45 (a)
BEST:CK00459 38
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea slc-28.1 37
  • 28 (a)
ManyToMany
slc-28.2 37
  • 28 (a)
ManyToMany
F27E11.1 38
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 44 (a)
ManyToMany
-- 37
  • 46 (a)
ManyToMany
Species with no ortholog for SLC28A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC28A2 Gene

ENSEMBL:
Gene Tree for SLC28A2 (if available)
TreeFam:
Gene Tree for SLC28A2 (if available)

Paralogs for SLC28A2 Gene

Paralogs for SLC28A2 Gene

Selected SIMAP similar genes for SLC28A2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC28A2: view

Variants for SLC28A2 Gene

Sequence variations from dbSNP and Humsavar for SLC28A2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs2899377 -- 45,250,445(-) TCCAA(A/T)CACCA upstream-variant-2KB
rs3759892 -- 45,250,511(+) TTCAC(A/G)TATTT upstream-variant-2KB
rs3759893 -- 45,250,752(+) TGGTG(G/T)TACAC upstream-variant-2KB
rs8039610 -- 45,250,541(+) cctaa(A/T)aatat upstream-variant-2KB
rs61187163 -- 45,250,888(+) AAAAA(-/A)GACAG upstream-variant-2KB

Relevant External Links for SLC28A2 Gene

HapMap Linkage Disequilibrium report
SLC28A2
Human Gene Mutation Database (HGMD)
SLC28A2

No data available for Structural Variations from Database of Genomic Variants (DGV) for SLC28A2 Gene

Disorders for SLC28A2 Gene

(1) Novoseek inferred disease relationships for SLC28A2 Gene

Disease -log(P) Hits PubMed IDs
leukemia 21.4 1

Relevant External Links for SLC28A2

Genetic Association Database (GAD)
SLC28A2
Human Genome Epidemiology (HuGE) Navigator
SLC28A2
genes like me logo Genes that share disorders with SLC28A2: view

No data available for UniProtKB/Swiss-Prot for SLC28A2 Gene

Publications for SLC28A2 Gene

  1. Na+-dependent purine nucleoside transporter from human kidney: cloning and functional characterization. (PMID: 9435697) Wang J. … Giacomini K.M. (Am. J. Physiol. 1997) 2 3 4 23
  2. Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. (PMID: 10087507) Ritzel M.W.L. … Young J.D. (Mol. Membr. Biol. 1998) 3 4 23
  3. Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2. (PMID: 10455109) Loewen S.K. … Young J.D. (J. Biol. Chem. 1999) 3 4 23
  4. Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2. (PMID: 15861032) Owen R.P. … Giacomini K.M. (Pharmacogenet. Genomics 2005) 3 4 23
  5. Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians. (PMID: 17700367) Li L. … Lee E.J.D. (Pharmacogenet. Genomics 2007) 3 4 23

Products for SLC28A2 Gene

Sources for SLC28A2 Gene

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