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SLC28A2 Gene

protein-coding   GIFtS: 57
GCID: GC15P045544

Solute Carrier Family 28 (Concentrative Nucleoside Transporter),...

(Previous names: solute carrier family 28 (sodium-coupled nucleoside transporter),...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 28 (Concentrative Nucleoside Transporter), Member
21 2
     CNT 22 3
CNT22 3 5     Na(+)/Nucleoside Cotransporter 22 3
Solute Carrier Family 28 (Sodium-Coupled Nucleoside Transporter), Member 21 2     SPNT12 5
Concentrative Nucleoside Transporter 22 3     HCNT22
Sodium-Coupled Nucleoside Transporter 22 3     HsT171532
Sodium/Purine Nucleoside Co-Transporter2 3     Sodium/Nucleoside Cotransporter 22
Solute Carrier Family 28 Member 22 3     hCNT23
SPNT2 3     

External Ids:    HGNC: 110021   Entrez Gene: 91532   Ensembl: ENSG000001378607   OMIM: 6062085   UniProtKB: O438683   

Export aliases for SLC28A2 gene to outside databases

Previous GC identifers: GC15P041102 GC15P038591 GC15P043123 GC15P043260 GC15P043331 GC15P022369


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC28A2 Gene:
SLC28A2 (solute carrier family 28 (concentrative nucleoside transporter), member 2) is a protein-coding gene. Diseases associated with SLC28A2 include b-cell chronic lymphocytic leukemia, and chronic lymphocytic leukemia. GO annotations related to this gene include purine nucleoside transmembrane transporter activity and nucleoside binding. An important paralog of this gene is SLC28A1.

UniProtKB/Swiss-Prot: S28A2_HUMAN, O43868
Function: Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the
nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a
critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues

Gene Wiki entry for SLC28A2 (Concentrative nucleoside transporter 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC28A2 gene promoter:
         AP-2rep   ER-alpha   STAT1   C/EBPbeta   STAT1beta   STAT1alpha   c-Rel   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC28A2 promoter sequence
   Search Chromatin IP Primers for SLC28A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC28A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15   Ensembl cytogenetic band:  15q21.1   HGNC cytogenetic band: 15q15

SLC28A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC28A2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P045544:  view genomic region     (about GC identifiers)

Start:
45,544,428 bp from pter      End:
45,568,149 bp from pter
Size:
23,722 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S28A2_HUMAN, O43868 (See protein sequence)
Recommended Name: Sodium/nucleoside cotransporter 2  
Size: 658 amino acids; 71926 Da
Secondary accessions: A8K7F9 O43239 Q52LZ0

Explore the universe of human proteins at neXtProt for SLC28A2: NX_O43868

Explore proteomics data for SLC28A2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC28A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004203.2  
    ENSEMBL proteins: 
     ENSP00000315006   ENSP00000454074   ENSP00000454046  
    Reactome Protein details: O43868

    SLC28A2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: CNT2
    SLC28 family

    5 InterPro protein domains:
     IPR018270 C_nuclsd_transpt_met_bac
     IPR008276 C_nuclsd_transpt
     IPR002668 Nuclsd_transpt2
     IPR011657 Nucleos_tra2_C
     IPR011642 Nucleoside_recog_Gate

    Graphical View of Domain Structure for InterPro Entry O43868

    ProtoNet protein and cluster: O43868

    2 Blocks protein domains:
    IPB002668 Na+ dependent nucleoside transporter
    IPB011642 Nucleoside recognition


    UniProtKB/Swiss-Prot: S28A2_HUMAN, O43868
    Similarity: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family


    SLC28A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S28A2_HUMAN, O43868
    Function: Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the
    nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a
    critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues
    Enzyme regulation: Inhibited by formycin B

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001882nucleoside binding IEA--
    GO:0005415nucleoside:sodium symporter activity IEA--
    GO:0015211purine nucleoside transmembrane transporter activity TAS9435697
         
    SLC28A2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC28A2:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC28A2
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S28A2_HUMAN, O43868: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    endoplasmic reticulum1
    extracellular1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9435697
    GO:0016020membrane TAS9435697

    SLC28A2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC28A2 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transmembrane transport of small molecules0.47
    2Transport of vitamins, nucleosides, and related molecules
    Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane0.00
    Transport of vitamins, nucleosides, and related molecules
    3One carbon pool by folate
    Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC28A2
        Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

    1 PharmGKB Pathway for SLC28A2
        Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics


    SLC28A2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC28A2: 
              Drug Transporters in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SLC28A2

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process TAS9435697
    GO:0006810transport ----
    GO:0015860purine nucleoside transmembrane transport TAS9435697
    GO:0055085transmembrane transport TAS--

    SLC28A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC28A2 (S28A2)

    1 HMDB Compound for SLC28A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    Selected Novoseek inferred chemical compound relationships for SLC28A2 gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nucleoside 88 106 12893280 (3), 18371949 (3), 15861032 (3), 16840788 (2) (see all 32)
    pyrimidine nucleoside 78.5 4 18371949 (1), 11641443 (1), 12856181 (1)
    uridine 78.4 17 15044622 (3), 10087507 (3), 11641443 (2), 12893280 (1) (see all 6)
    purine nucleoside 78.3 5 18371949 (1), 10455109 (1), 12856181 (1), 10087507 (1)
    inosine 78.3 4 18371949 (1), 9435697 (1)
    5-fluorouridine 72.2 2 15044622 (1)
    fudr 68.1 6 16462026 (2), 12893280 (1), 15044622 (1)
    purine 67.8 5 15870078 (1), 11641443 (1), 12856181 (1), 11156184 (1)
    2-chlorodeoxyadenosine 64.9 14 16840788 (4), 15044622 (1)
    pyrimidine 62.7 7 12856181 (2), 19380585 (1), 10455109 (1), 18668436 (1)



    SLC28A2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC28A2 gene: 
    NM_004212.3  

    Unigene Cluster for SLC28A2:

    Solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
    Hs.367833  [show with all ESTs]
    Unigene Representative Sequence: NM_004212
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000347644(uc001zva.2) ENST00000560438 ENST00000559924 ENST00000560767

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      QuantiFast Probe-based Assays in human, mouse, rat SLC28A2

    Additional mRNA sequence: 

    AF036109.1 AK222709.1 AK291974.1 BC093737.1 BC112047.1 U84392.1 

    3 DOTS entries:

    DT.405169  DT.75185178  DT.92015193 

    13 AceView cDNA sequences:

    AK025121 AU076734 U84392 NM_004212 AW351757 AF036109 AA377292 AI913711 
    BX107764 AA358822 BG199614 AU099677 BG006167 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC28A2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                                        -                                                               
    SP2:                                -                                                                                       


    ECgene alternative splicing isoforms for SLC28A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC28A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGCAGAG
    SLC28A2 Expression
    About this image


    SLC28A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Midgut
     
     NULL (Uncategorized)
             Endoderm progenitor-like cells
    SLC28A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC28A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.367833

    UniProtKB/Swiss-Prot: S28A2_HUMAN, O43868
    Tissue specificity: Expressed in heart and skeletal muscle followed by liver, kidney, intestine, pancreas,
    placenta and brain. Weak expression in lung

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC28A2: 
              Drug Transporters in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC28A2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC28A2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc28a21 , 5 solute carrier family 28 (sodium-coupled nucleoside more1, 5 82.98(n)1
    80.4(a)1
      2 (60.63 cM)5
    2693461  NM_172980.21  NP_766568.11 
     1224264775 
    chicken
    (Gallus gallus)
    Aves SLC28A21 solute carrier family 28 (sodium-coupled nucleoside more 65.33(n)
    60.22(a)
      415338  XM_004943610.1  XP_004943667.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    52(a)
    1 → many
    GL343490.1(96354-106332)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc28a21 solute carrier family 28 (sodium-coupled nucleoside more 63.52(n)
    62.63(a)
      100496776  XM_002934569.2  XP_002934615.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-24l11.11 si:dkey-24l11.1 59.52(n)
    56.1(a)
      571287  NM_001081497.1  NP_001074966.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG117783
    CNT11
    nucleoside:sodium symporter3
    Concentrative Nucleoside Transporter 11
    45(a)
    (best of 2)3
    50.72(n)1
    43.48(a)1
      45A13
    359151  NM_136603.21  NP_610447.21 
    worm
    (Caenorhabditis elegans)
    Secernentea F27E11.13 nucleoside transporter 31(a)   V(3463660-3465965)   --


    ENSEMBL Gene Tree for SLC28A2 (if available)
    TreeFam Gene Tree for SLC28A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC28A2 gene
    SLC28A12  SLC28A32  
    2 SIMAP similar genes for SLC28A2 using alignment to 4 protein entries:     S28A2_HUMAN (see all proteins):
    SLC28A1    SLC28A3

    SLC28A2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC28A2 (see all 639)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs28993771,2
    C,F,O,A,H--45542643(-) TCCAAT/ACACCA 1 -- us2k118Minor allele frequency- A:0.19NS EA NA WA CSA 812
    rs37598921,2
    C,F,A,H--45542709(+) TTCACA/GTATTT 1 -- us2k1 tfbs313Minor allele frequency- G:0.38NS EA NA WA CSA 788
    rs80396101,2
    C,F,H--45542739(+) cctaaT/Aaatat 1 -- us2k1 tfbs34Minor allele frequency- A:0.00NS EA 418
    rs1909783481,2
    --45542924(+) AAATTA/TAAAAA 1 -- us2k10--------
    rs37598931,2
    C,F--45542950(+) TGGTGG/TTACAC 1 -- us2k111Minor allele frequency- T:0.48NA WA CSA EA 373
    rs611871631,2
    C--45543086(+) AAAAA-/A/AAAA
            
    GACAG
    1 -- us2k10--------
    rs790414351,2
    C--45543102(+) AAAAAG/AACAGA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs777994321,2
    C--45543104(+) AAAGAC/AAGAGA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1828121031,2
    --45543203(+) AGGGGA/TCCTAA 1 -- us2k10--------
    rs1464065261,2
    --45543248(+) TCTTTC/TTTTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC28A2 (45544428 - 45568149 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SLC28A2: --
    Human Gene Mutation Database (HGMD): SLC28A2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC28A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC28A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606208    OMIM disorders: --

    10 diseases for SLC28A2:    
    About MalaCards
    b-cell chronic lymphocytic leukemia    chronic lymphocytic leukemia    choroiditis    choriocarcinoma
    inflammatory bowel disease    kidney disease    pancreatic cancer    leukemia
    pancreatitis    hiv-1


    SLC28A2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SLC28A2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 21.4 2 11641443 (1)

    Genetic Association Database (GAD): SLC28A2
    Human Genome Epidemiology (HuGE) Navigator: SLC28A2 (6 documents)

    Export disorders for SLC28A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC28A2 gene, integrated from 10 sources (see all 66):
    (articles sorted by number of sources associating them with SLC28A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Na+-dependent purine nucleoside transporter from human kidney: cloning and functional characterization. (PubMed id 9435697)1, 2, 3, 9 Wang J....Giacomini K.M. (Am. J. Physiol. 1997)
    2. Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians. (PubMed id 17700367)1, 2, 9 Li L.... Lee E.J.D. (Pharmacogenet. Genomics 2007)
    3. Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2. (PubMed id 15861032)1, 2, 9 Owen R.P.... Giacomini K.M. (Pharmacogenet. Genomics 2005)
    4. Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. (PubMed id 10087507)1, 2, 9 Ritzel M.W.L....Young J.D. (Mol. Membr. Biol. 1998)
    5. Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2. (PubMed id 10455109)1, 2, 9 Loewen S.K....Young J.D. (J. Biol. Chem. 1999)
    6. Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity. (PubMed id 20028759)1, 4 Okazaki T....Li D. (Clin. Cancer Res. 2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Contribution of adenosine related genes to the risk of depression with disturbed sleep. (PubMed id 20392501)1, 4 Gass N....Paunio T. (J Affect Disord 2010)
    9. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (Cancer Res. 2008)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9153 HGNC: 11002 AceView: SLC28A2 Ensembl:ENSG00000137860 euGenes: HUgn9153
    ECgene: SLC28A2 H-InvDB: SLC28A2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC28A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SLC28A2 gene:
    Search GeneIP for patents involving SLC28A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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