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Aliases for SLC28A1 Gene

Aliases for SLC28A1 Gene

  • Solute Carrier Family 28 (Concentrative Nucleoside Transporter), Member 1 2 3
  • Solute Carrier Family 28 (Sodium-Coupled Nucleoside Transporter), Member 1 2 3
  • Sodium-Coupled Nucleoside Transporter 1 3 4
  • Concentrative Nucleoside Transporter 1 3 4
  • Solute Carrier Family 28 Member 1 3 4
  • Na(+)/Nucleoside Cotransporter 1 3 4
  • HCNT1 3 4
  • CNT1 3 4
  • CNT 1 4

External Ids for SLC28A1 Gene

Previous GeneCards Identifiers for SLC28A1 Gene

  • GC15P081540
  • GC11M000494
  • GC15P083015
  • GC15P083157
  • GC15P083228
  • GC15P085427
  • GC15P061513

Summaries for SLC28A1 Gene

GeneCards Summary for SLC28A1 Gene

SLC28A1 (Solute Carrier Family 28 (Concentrative Nucleoside Transporter), Member 1) is a Protein Coding gene. Diseases associated with SLC28A1 include macroglobulinemia. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of vitamins, nucleosides, and related molecules. GO annotations related to this gene include nucleoside binding and nucleoside:sodium symporter activity. An important paralog of this gene is SLC28A3.

UniProtKB/Swiss-Prot for SLC28A1 Gene

  • Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3-azido-3-deoxythymidine (AZT) and 2,3-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine

Gene Wiki entry for SLC28A1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC28A1 Gene

Genomics for SLC28A1 Gene

Regulatory Elements for SLC28A1 Gene

Genomic Location for SLC28A1 Gene

Chromosome:
15
Start:
84,884,577 bp from pter
End:
84,975,651 bp from pter
Size:
91,075 bases
Orientation:
Plus strand

Genomic View for SLC28A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC28A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC28A1 Gene

Proteins for SLC28A1 Gene

  • Protein details for SLC28A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00337-S28A1_HUMAN
    Recommended name:
    Sodium/nucleoside cotransporter 1
    Protein Accession:
    O00337
    Secondary Accessions:
    • A0AV42
    • A8K7I2
    • O00335
    • O00336
    • Q5U5S6
    • Q5U648
    • Q9UEZ9

    Protein attributes for SLC28A1 Gene

    Size:
    649 amino acids
    Molecular mass:
    71584 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC28A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC28A1 Gene

Proteomics data for SLC28A1 Gene at MOPED

Post-translational modifications for SLC28A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC28A1 Gene

No data available for DME Specific Peptides for SLC28A1 Gene

Domains & Families for SLC28A1 Gene

Gene Families for SLC28A1 Gene

HGNC:
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

O00337

UniProtKB/Swiss-Prot:

S28A1_HUMAN :
  • Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
Family:
  • Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
genes like me logo Genes that share domains with SLC28A1: view

Function for SLC28A1 Gene

Molecular function for SLC28A1 Gene

GENATLAS Biochemistry:
solute carrier family 28,member A1,renal reabsorption transporter of physiological nucleosides,pyrimidines,adenosin and drugs
UniProtKB/Swiss-Prot Function:
Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3-azido-3-deoxythymidine (AZT) and 2,3-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine

Gene Ontology (GO) - Molecular Function for SLC28A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001882 nucleoside binding --
GO:0005337 nucleoside transmembrane transporter activity TAS 9124315
GO:0005415 nucleoside:sodium symporter activity --
GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity IBA --
genes like me logo Genes that share ontologies with SLC28A1: view

Phenotypes for SLC28A1 Gene

genes like me logo Genes that share phenotypes with SLC28A1: view

Animal Model Products

CRISPR Products

miRNA for SLC28A1 Gene

miRTarBase miRNAs that target SLC28A1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC28A1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC28A1 Gene

Localization for SLC28A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC28A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC28A1 Gene COMPARTMENTS Subcellular localization image for SLC28A1 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC28A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9124315
GO:0016020 membrane TAS 9124315
genes like me logo Genes that share ontologies with SLC28A1: view

Pathways & Interactions for SLC28A1 Gene

genes like me logo Genes that share pathways with SLC28A1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for SLC28A1 Gene

Gene Ontology (GO) - Biological Process for SLC28A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 9124315
GO:0006810 transport --
GO:0006863 purine nucleobase transport IBA --
GO:0015855 pyrimidine nucleobase transport IBA --
GO:0015858 nucleoside transport TAS 9124315
genes like me logo Genes that share ontologies with SLC28A1: view

No data available for SIGNOR curated interactions for SLC28A1 Gene

Drugs & Compounds for SLC28A1 Gene

(13) Drugs for SLC28A1 Gene - From: NovoSeek, PharmGKB, FDA Approved Drugs, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gemcitabine Approved Pharma Transporter Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1800
Stavudine Approved, Investigational Pharma Transporter 171
Zidovudine Approved Pharma Transporter 489
Gemzar Approved May 1996 Pharma 0
Cytarabine Approved, Investigational Pharma 995

(14) Additional Compounds for SLC28A1 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
2-Chlorodeoxyadenosine
5-Deoxy-5-fluorouridine
5fluorouracil
CASS
genes like me logo Genes that share compounds with SLC28A1: view

Transcripts for SLC28A1 Gene

Unigene Clusters for SLC28A1 Gene

Solute carrier family 28 (sodium-coupled nucleoside transporter), member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC28A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC28A1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - -
SP5: -
SP6: -
SP7: - -

ExUns: 21a · 21b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for SLC28A1 Gene

GeneLoc Exon Structure for
SLC28A1
ECgene alternative splicing isoforms for
SLC28A1

Expression for SLC28A1 Gene

mRNA expression in normal human tissues for SLC28A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC28A1 Gene

This gene is overexpressed in Liver (x31.3) and Kidney - Cortex (x15.8).

Protein differential expression in normal tissues from HIPED for SLC28A1 Gene

This gene is overexpressed in Skin (50.5) and Peripheral blood mononuclear cells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC28A1 Gene



SOURCE GeneReport for Unigene cluster for SLC28A1 Gene Hs.459187

mRNA Expression by UniProt/SwissProt for SLC28A1 Gene

O00337-S28A1_HUMAN
Tissue specificity: Expressed in kidney
genes like me logo Genes that share expression patterns with SLC28A1: view

Protein tissue co-expression partners for SLC28A1 Gene

Primer Products

In Situ Assay Products

Orthologs for SLC28A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC28A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC28A1 35
  • 86.47 (n)
  • 85.34 (a)
SLC28A1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC28A1 35
  • 85.51 (n)
  • 81.16 (a)
SLC28A1 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc28a1 35
  • 83.57 (n)
  • 84.08 (a)
Slc28a1 16
Slc28a1 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC28A1 35
  • 99.28 (n)
  • 98.92 (a)
SLC28A1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc28a1 35
  • 83.1 (n)
  • 82.84 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC28A1 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii SLC28A2 36
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta BEST:CK00459 37
  • 42 (a)
CG11778 37
  • 42 (a)
CG8083 36
  • 33 (a)
ManyToMany
CNT1 36
  • 32 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F27E11.1 37
  • 29 (a)
slc-28.1 36
  • 27 (a)
ManyToMany
slc-28.2 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
Species with no ortholog for SLC28A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC28A1 Gene

ENSEMBL:
Gene Tree for SLC28A1 (if available)
TreeFam:
Gene Tree for SLC28A1 (if available)

Paralogs for SLC28A1 Gene

Paralogs for SLC28A1 Gene

(2) SIMAP similar genes for SLC28A1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC28A1: view

Variants for SLC28A1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SLC28A1 Gene

O00337-S28A1_HUMAN
Three variant forms of isoform 1 (A, B and C) are expressed in the kidney. All three variant forms have similar nucleoside transport activity

Sequence variations from dbSNP and Humsavar for SLC28A1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs732632 -- 84,948,081(-) GCCTA(C/T)TGGGA intron-variant
rs732633 -- 84,947,876(-) TAGCT(C/T)ACACT intron-variant
rs876802 -- 84,971,470(+) ggtcc(A/G)tcccc intron-variant
rs879799 -- 84,968,239(-) tatta(C/T)cccat intron-variant
rs896359 -- 84,883,390(+) TTTTC(C/T)ATTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC28A1 Gene

Variant ID Type Subtype PubMed ID
esv2672879 CNV Deletion 23128226
nsv524050 CNV Loss 19592680
dgv322n27 CNV Gain 19166990
nsv471257 CNV Gain 18288195
esv2673757 CNV Deletion 23128226
esv2749965 CNV Deletion 23290073
nsv904457 CNV Loss 21882294
esv1025455 CNV Insertion 17803354
esv2749966 CNV Deletion 23290073
nsv519285 CNV Loss 19592680
nsv904458 CNV Loss 21882294
nsv457223 CNV Loss 19166990
esv2749967 CNV Deletion 23290073
esv4622 CNV Deletion 18987735
esv1010774 CNV Deletion 20482838
esv1131956 CNV Deletion 17803354
nsv525868 CNV Loss 19592680
nsv94824 CNV Insertion 16902084

Variation tolerance for SLC28A1 Gene

Residual Variation Intolerance Score: 65.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.52; 98.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC28A1 Gene

HapMap Linkage Disequilibrium report
SLC28A1
Human Gene Mutation Database (HGMD)
SLC28A1

Disorders for SLC28A1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC28A1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
macroglobulinemia
  • waldenstrom macroglobulinemia
- elite association

Relevant External Links for SLC28A1

Genetic Association Database (GAD)
SLC28A1
Human Genome Epidemiology (HuGE) Navigator
SLC28A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC28A1
genes like me logo Genes that share disorders with SLC28A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC28A1 Gene

Publications for SLC28A1 Gene

  1. Interaction of nucleoside inhibitors of HIV-1 reverse transcriptase with the concentrative nucleoside transporter-1 (SLC28A1). (PMID: 15651758) Cano-Soldado P. … Pastor-Anglada M. (Antivir. Ther. (Lond.) 2004) 23 25 67
  2. Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1). (PMID: 9124315) Ritzel M.W.L. … Young J.D. (Am. J. Physiol. 1997) 2 23 67
  3. Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity. (PMID: 20028759) Okazaki T. … Li D. (Clin. Cancer Res. 2010) 23 67
  4. Expression and functional activity of nucleoside transporters in human choroid plexus. (PMID: 20150980) Redzic Z.B. … Isakovic A.J. (Cerebrospinal Fluid Res 2010) 23 67
  5. Expression of nucleoside transporters, deoxycitidine kinase, ribonucleotide reductase regulatory subunits, and gemcitabine catabolic enzymes in primary ovarian cancer. (PMID: 19639316) Ferrandina G. … Del Tacca M. (Cancer Chemother. Pharmacol. 2010) 23 67

Products for SLC28A1 Gene

Sources for SLC28A1 Gene

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