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Aliases for SLC28A1 Gene

Aliases for SLC28A1 Gene

  • Solute Carrier Family 28 (Concentrative Nucleoside Transporter), Member 1 2 3
  • CNT1 3 4 6
  • Solute Carrier Family 28 (Sodium-Coupled Nucleoside Transporter), Member 1 2 3
  • Sodium-Coupled Nucleoside Transporter 1 3 4
  • Concentrative Nucleoside Transporter 1 3 4
  • Solute Carrier Family 28 Member 1 3 4
  • Na(+)/Nucleoside Cotransporter 1 3 4
  • HCNT1 3 4
  • Sodium/Nucleoside Cotransporter 1 3
  • CNT 1 4

External Ids for SLC28A1 Gene

Summaries for SLC28A1 Gene

GeneCards Summary for SLC28A1 Gene

SLC28A1 (Solute Carrier Family 28 (Concentrative Nucleoside Transporter), Member 1) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include nucleoside binding and nucleoside:sodium symporter activity. An important paralog of this gene is SLC28A3.

UniProtKB/Swiss-Prot for SLC28A1 Gene

  • Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3-azido-3-deoxythymidine (AZT) and 2,3-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine

Gene Wiki entry for SLC28A1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC28A1 Gene

Genomics for SLC28A1 Gene

Genomic Location for SLC28A1 Gene

Start:
84,884,604 bp from pter
End:
84,945,796 bp from pter
Size:
61,193 bases
Orientation:
Plus strand

Genomic View for SLC28A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC28A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC28A1 Gene

Regulatory Elements for SLC28A1 Gene

Proteins for SLC28A1 Gene

  • Protein details for SLC28A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00337-S28A1_HUMAN
    Recommended name:
    Sodium/nucleoside cotransporter 1
    Protein Accession:
    O00337
    Secondary Accessions:
    • A0AV42
    • A8K7I2
    • O00335
    • O00336
    • Q5U5S6
    • Q5U648
    • Q9UEZ9

    Protein attributes for SLC28A1 Gene

    Size:
    649 amino acids
    Molecular mass:
    71584 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC28A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC28A1 Gene

Proteomics data for SLC28A1 Gene at MOPED

Post-translational modifications for SLC28A1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn605 and Asn643

Other Protein References for SLC28A1 Gene

No data available for DME Specific Peptides for SLC28A1 Gene

Domains for SLC28A1 Gene

Gene Families for SLC28A1 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

UniProtKB/Swiss-Prot:

S28A1_HUMAN
Family:
  • Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.:
    • O00337
genes like me logo Genes that share domains with SLC28A1: view

Function for SLC28A1 Gene

Molecular function for SLC28A1 Gene

GENATLAS Biochemistry: solute carrier family 28,member A1,renal reabsorption transporter of physiological nucleosides,pyrimidines,adenosin and drugs
UniProtKB/Swiss-Prot Function: Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3-azido-3-deoxythymidine (AZT) and 2,3-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine

Gene Ontology (GO) - Molecular Function for SLC28A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001882 nucleoside binding IEA --
GO:0005337 nucleoside transmembrane transporter activity TAS 9124315
GO:0005415 nucleoside:sodium symporter activity IEA --
genes like me logo Genes that share ontologies with SLC28A1: view

Phenotypes for SLC28A1 Gene

GenomeRNAi human phenotypes for SLC28A1:
genes like me logo Genes that share phenotypes with SLC28A1: view

miRNA for SLC28A1 Gene

miRTarBase miRNAs that target SLC28A1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC28A1 Gene

Localization for SLC28A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC28A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC28A1 Gene COMPARTMENTS Subcellular localization image for SLC28A1 gene
Compartment Confidence
plasma membrane 5
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC28A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane TAS 9124315
genes like me logo Genes that share ontologies with SLC28A1: view

Pathways for SLC28A1 Gene

genes like me logo Genes that share pathways with SLC28A1: view

Interacting Proteins for SLC28A1 Gene

Gene Ontology (GO) - Biological Process for SLC28A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 9124315
GO:0006810 transport --
GO:0015858 nucleoside transport TAS 9124315
GO:0055085 transmembrane transport TAS --
GO:1901642 nucleoside transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC28A1: view

Compounds for SLC28A1 Gene

(1) HMDB Compounds for SLC28A1 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5

(25) Novoseek inferred chemical compound relationships for SLC28A1 Gene

Compound -log(P) Hits PubMed IDs
nucleoside 89.4 73
pyrimidine nucleoside 79.8 5
uridine 79.7 15
5-fluorouridine 76.9 3
purine nucleoside 70.5 4
genes like me logo Genes that share compounds with SLC28A1: view

Transcripts for SLC28A1 Gene

Unigene Clusters for SLC28A1 Gene

Solute carrier family 28 (sodium-coupled nucleoside transporter), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC28A1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - -
SP5: -
SP6: -
SP7: - -

ExUns: 21a · 21b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for SLC28A1 Gene

GeneLoc Exon Structure for
SLC28A1
ECgene alternative splicing isoforms for
SLC28A1

Expression for SLC28A1 Gene

mRNA expression in normal human tissues for SLC28A1 Gene

mRNA differential expression in normal tissues according to GTEx for SLC28A1 Gene

This gene is overexpressed in Liver (31.3) and Kidney - Cortex (15.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC28A1 Gene

SOURCE GeneReport for Unigene cluster for SLC28A1 Gene Hs.459187

mRNA Expression by UniProt/SwissProt for SLC28A1 Gene

O00337-S28A1_HUMAN
Tissue specificity: Expressed in kidney
genes like me logo Genes that share expressions with SLC28A1: view

Orthologs for SLC28A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC28A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC28A1 36
  • 99.28 (n)
  • 98.92 (a)
SLC28A1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC28A1 36
  • 86.47 (n)
  • 85.34 (a)
SLC28A1 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC28A1 36
  • 85.51 (n)
  • 81.16 (a)
SLC28A1 37
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc28a1 36
  • 83.57 (n)
  • 84.08 (a)
Slc28a1 16
Slc28a1 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC28A1 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 64 (a)
ManyToMany
-- 37
  • 69 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Slc28a1 36
  • 83.1 (n)
  • 82.84 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 52 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii SLC28A2 37
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8083 37
  • 33 (a)
ManyToMany
CNT1 37
  • 32 (a)
ManyToMany
CG11778 38
  • 42 (a)
BEST:CK00459 38
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea slc-28.1 37
  • 27 (a)
ManyToMany
slc-28.2 37
  • 27 (a)
ManyToMany
F27E11.1 38
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 45 (a)
ManyToMany
-- 37
  • 46 (a)
ManyToMany
Species with no ortholog for SLC28A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC28A1 Gene

ENSEMBL:
Gene Tree for SLC28A1 (if available)
TreeFam:
Gene Tree for SLC28A1 (if available)

Paralogs for SLC28A1 Gene

Paralogs for SLC28A1 Gene

Selected SIMAP similar genes for SLC28A1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC28A1: view

Variants for SLC28A1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SLC28A1 Gene

O00337-S28A1_HUMAN
Three variant forms of isoform 1 (A, B and C) are expressed in the kidney. All three variant forms have similar nucleoside transport activity

Sequence variations from dbSNP and Humsavar for SLC28A1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs896359 -- 84,883,390(+) TTTTC(C/T)ATTTT upstream-variant-2KB
rs896360 -- 84,911,386(-) CTCCT(C/G)TCTGG intron-variant
rs896361 -- 84,911,312(-) ACCAA(C/T)GGTCA intron-variant
rs896362 -- 84,899,711(-) Ctgaa(A/G)aatta intron-variant
rs896363 -- 84,899,366(-) tggac(A/G)taatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC28A1 Gene

Variant ID Type Subtype PubMed ID
esv2672879 CNV Deletion 23128226
nsv524050 CNV Loss 19592680
dgv322n27 CNV Gain 19166990
nsv471257 CNV Gain 18288195
esv2673757 CNV Deletion 23128226
esv2749965 CNV Deletion 23290073
nsv904457 CNV Loss 21882294
esv1025455 CNV Insertion 17803354
esv2749966 CNV Deletion 23290073
nsv519285 CNV Loss 19592680
nsv904458 CNV Loss 21882294
nsv457223 CNV Loss 19166990
esv2749967 CNV Deletion 23290073
esv4622 CNV Deletion 18987735
esv1010774 CNV Deletion 20482838
esv1131956 CNV Deletion 17803354
nsv525868 CNV Loss 19592680
nsv94824 CNV Insertion 16902084

Relevant External Links for SLC28A1 Gene

HapMap Linkage Disequilibrium report
SLC28A1
Human Gene Mutation Database (HGMD)
SLC28A1

Disorders for SLC28A1 Gene

(3) Novoseek inferred disease relationships for SLC28A1 Gene

Disease -log(P) Hits PubMed IDs
adenocarcinoma 0.726 2
hepatocellular carcinoma 0 1
tumors 0 4

Relevant External Links for SLC28A1

Genetic Association Database (GAD)
SLC28A1
Human Genome Epidemiology (HuGE) Navigator
SLC28A1
genes like me logo Genes that share disorders with SLC28A1: view

No data available for UniProtKB/Swiss-Prot for SLC28A1 Gene

Publications for SLC28A1 Gene

  1. Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1). (PMID: 9124315) Ritzel M.W.L. … Young J.D. (Am. J. Physiol. 1997) 2 3 4 23
  2. Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2. (PMID: 10455109) Loewen S.K. … Young J.D. (J. Biol. Chem. 1999) 3 4 23
  3. Polymorphisms in transporter and phase II metabolism genes as potential modifiers of the predisposition to and treatment outcome of de novo acute myeloid leukemia in Israeli ethnic groups. (PMID: 18207572) MA1ller P. … Rund D. (Leuk. Res. 2008) 3 23 49
  4. Impact of concentrative nucleoside transporter 1 gene polymorphism on oral bioavailability of mizoribine in stable kidney transplant recipients. (PMID: 19912163) Naito T. … Kawakami J. (Basic Clin. Pharmacol. Toxicol. 2010) 3 23 49
  5. Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity. (PMID: 20028759) Okazaki T. … Li D. (Clin. Cancer Res. 2010) 3 23 49

Products for SLC28A1 Gene

Sources for SLC28A1 Gene

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