SLC28A1 Gene
protein-coding GIFtS: 56
GCID: GC15P085427
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|
solute carrier family 28 (sodium-coupled nucleoside transporter),...
| |
Aliases
for SLC28A1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 28 (Sodium-Coupled Nucleoside Transporter), Member11 2 | | CNT 12 3 | | CNT11 2 3 5 | | Na(+)/Nucleoside Cotransporter 12 3 | | Concentrative Nucleoside Transporter 12 3 | | HCNT12 | | Sodium-Coupled Nucleoside Transporter 12 3 | | Sodium/Nucleoside Cotransporter 12 | | Solute Carrier Family 28 Member 12 3 | | HCNT12 |
Export aliases for SLC28A1 gene to outside databasesPrevious GC identifers: GC15P081540 GC11M000494 GC15P083015 GC15P083157 GC15P083228 GC15P061513 |
Summaries
for SLC28A1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: S28A1_HUMAN, O00337Function: Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transportsystem cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports theantiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may beinvolved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquiredimmunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine>> guanosine, inosine
Gene Wiki entry for SLC28A1 (Concentrative nucleoside transporter 1)
|
Genomic Views
for SLC28A1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010274.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC28A1 gene promoter:
Bach1 HTF Ik-3 Tal-1beta LCR-F1 MZF-1 CREB AREB6 Zic1 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC28A1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC28A1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q25.3 Ensembl cytogenetic band: 15q25.3 HGNC cytogenetic band: 15q25.3SLC28A1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P085427: view genomic region
(about GC identifiers)
Start:
|
85,427,885 bp from pter |
End:
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85,518,876 bp from pter |
Size:
|
90,992 bases |
Orientation:
|
plus strand |
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Proteins
for SLC28A1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S28A1_HUMAN, O00337 (See
protein sequence)Recommended Name: Sodium/nucleoside cotransporter 1 Size: 649 amino acids; 71584 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A0AV42 A8K7I2 O00335 O00336 Q5U5S6 Q5U648 Q9UEZ9Alternative splicing: 2 isoforms: O00337-1 O00337-2 Explore the universe of human proteins at neXtProt for SLC28A1: NX_O00337
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00337
SLC28A1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_004204.3 NP_964014.1
ENSEMBL proteins: ENSP00000341629 ENSP00000286749 ENSP00000444700 ENSP00000440546 ENSP00000443752 ENSP00000378074 ENSP00000443764 Reactome Protein details: O00337
Human Recombinant Protein Products for SLC28A1:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
SLC28A1 for ontologies About GeneDecksing
SLC28A1 Antibody Products:
Assay Products for SLC28A1: |
Protein
Domains /
Families
for SLC28A1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC28A1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O00337ProtoNet protein and cluster: O00337 2 Blocks protein families: IPB002668 Na+ dependent nucleoside transporter IPB011642 Nucleoside recognition
UniProtKB/Swiss-Prot: S28A1_HUMAN, O00337Similarity: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family |
Function
for SLC28A1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: S28A1_HUMAN, O00337Function: Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transportsystem cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports theantiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may beinvolved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquiredimmunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine>> guanosine, inosine Genatlas biochemistry entry for SLC28A1:solute carrier family 28,member A1,renal reabsorption transporter of physiological nucleosides,pyrimidines,adenosin anddrugs
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001882 | nucleoside binding |
IEA | -- | | GO:0005337 | nucleoside transmembrane transporter activity |
TAS | 9124315 | | GO:0005350 | pyrimidine nucleobase transmembrane transporter activity |
-- | -- | | GO:0005415 | nucleoside:sodium symporter activity |
IEA | -- | | GO:0015389 | pyrimidine- and adenine-specific:sodium symporter activity |
-- | -- |
SLC28A1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for SLC28A1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC28A1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC28A1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): SLC28A1 (NM_004213) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC28A1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC28A1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC28A1 |
|
Pathways & Interactions
for SLC28A1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | SLC-mediated transmembrane transport | | | 2 | Gemcitabine Pathway, Pharmacodynamics | | | 3 | Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics | | | 4 | Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane | | | 5 | Transport of organic anions | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for SLC28A1
2  PharmGKB Pathways for SLC28A1
SLC28A1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC28A1
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
SLC28A1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC28A1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SLC28A1 for compounds About GeneDecksing
 Browse Tocris compounds for SLC28A1
1 HMDB Compound for SLC28A1 About this table
10/25 Novoseek chemical compound relationships for SLC28A1 gene (see all 25) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| nucleoside |
89.4 |
145 |
14978229 (5), 18371949 (3), 10353719 (3), 20060452 (3) (see all 47) |
| pyrimidine nucleoside |
79.8 |
7 |
20060452 (2), 15651758 (1), 18371949 (1), 12856181 (1) |
| uridine |
79.7 |
22 |
15044622 (3), 15194733 (3), 14668133 (2), 14645682 (2) (see all 8) |
| 5-fluorouridine |
76.9 |
8 |
15044622 (1), 10353719 (1), 15194733 (1) |
| purine nucleoside |
70.5 |
4 |
14701834 (1), 18371949 (1), 12687033 (1), 12856181 (1) |
| gemcitabine |
70.4 |
9 |
18371949 (2), 14581375 (2), 14668133 (1), 16868547 (1) (see all 6) |
| pyrimidine |
67.3 |
9 |
12856181 (2), 10996312 (1), 19380585 (1), 18668436 (1) |
| cass |
66.7 |
3 |
10353719 (1), 9124315 (1) |
| 5'-deoxy-5-fluorouridine |
66.7 |
5 |
18053967 (2), 14701834 (1), 11353816 (1) |
| 2-chlorodeoxyadenosine |
66.6 |
4 |
15044622 (1), 19647871 (1) |
Search CenterWatch for drugs/clinical trials and news about SLC28A1 / S28A1
|
Transcripts
for SLC28A1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC28A1 gene (2 alternative transcripts): NM_004213.3 NM_201651.1 Unigene Cluster for SLC28A1: Solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 Hs.459187 [show with all ESTs]Unigene Representative Sequence: NM_0042137 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000338602(uc002blf.3) ENST00000286749(uc010bnb.3 uc010upe.2)
ENST00000537624(uc010upf.1 uc010upg.1) ENST00000537216 ENST00000538177
ENST00000394573(uc002blg.3) ENST00000537703(uc010upd.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC28A1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC28A1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SLC28A1 (NM_004213) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC28A1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC28A1 |
Additional cDNA sequence: AF309632.1 AK291997.1 AK296074.1 AK296075.1 AK296119.1 AK298369.1 AK309571.1 AK309578.1 AK311387.1 BC029788.1 BC039898.1 BC126204.1 BC126206.1 BC143908.1 U62967.1 U62968.1 7 DOTS entries: DT.91975003 DT.99964162 DT.97839929 DT.121072089 DT.121072099 DT.65284991 DT.86844713 24/38 AceView cDNA sequences (see all 38): NM_201651 AW451748 BU629637 AF309632 AI791815 AA918008 BM762570 U62968 BM761472 BC029788 BM843523 U62967 BM762623 BX112233 BI764879 BM843687 BM764268 BM845109 BC039898 AI733134 NM_004213 BM843628 BM761696 BX098316
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SLC28A1 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21a | · | 21b |
|---|
|
| SP1: | | | | | |
| SP2: | | | | | |
| SP3: | | | | | |
| SP4: | | | | | |
| SP5: | | | | |
ECgene alternative splicing isoforms for SLC28A1
|
Expression
for SLC28A1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC28A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGGAGGCT
About this image
See SLC28A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC28A1
SOURCE GeneReport for Unigene cluster: Hs.459187
UniProtKB/Swiss-Prot: S28A1_HUMAN, O00337Tissue specificity: Expressed in kidney
SABiosciences Expression via Pathway-Focused PCR Array including SLC28A1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC28A1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC28A1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC28A1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC28A1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC28A1 |
Orthologs
for SLC28A1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for SLC28A1 gene from 7/19 species (see all 19) About this table
ENSEMBL Gene Tree for SLC28A1 (if available)
TreeFam Gene Tree for SLC28A1 (if available) |
Paralogs
for SLC28A1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC28A1 gene
- SLC28A22 SLC28A32
2 SIMAP similar genes for SLC28A1 using alignment to 5 protein entries: S28A1_HUMAN (see all proteins):SLC28A2 SLC28A3
SLC28A1 for paralogs About GeneDecksing
|
Genomic Variants
for SLC28A1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: S28A1_HUMAN, O00337Polymorphism: Three variant forms of isoform 1 (A, B and C) are expressed in the kidney. All three variant forms havesimilar nucleoside transport activity
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC28A1 (85427885 - 85518876 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for SLC28A1
3 CNVs: 49603 29645 53338
2 Indels: 25571 41773
Human Gene Mutation Database (HGMD): SLC28A1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC28A1 |
|
Disorders
/ Diseases
for SLC28A1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC28A1 for disorders About GeneDecksing
OMIM gene information: 606207
OMIM disorders: --
18  diseases for SLC28A1: About MalaCardswaldenstrom macroglobulinemia acquired immunodeficiency syndrome macroglobulinemia chronic lymphocytic leukemia
acute myeloid leukemia lymphocytic leukemia myeloid leukemia hepatocellular carcinoma
leukemia choroiditis ovarian cancer immunodeficiency
pancreatic cancer lung cancer breast cancer pancreatitis
carcinoma cholesterol
3 Novoseek disease relationships for SLC28A1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| adenocarcinoma |
0.726 |
2 |
20028759 (1), 15386342 (1) |
| hepatocellular carcinoma |
0 |
1 |
11396615 (1) |
| tumors |
0 |
5 |
15386342 (3), 11353816 (1) |
Human Genome Epidemiology (HuGE) Navigator: SLC28A1 (10 documents)
Export disorders for SLC28A1 gene to outside databases
|
Publications
for SLC28A1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC28A1 gene, integrated from 9 sources (see all 82):
(articles sorted by number of sources associating them with SLC28A1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1). (PubMed id 9124315)1, 2, 3, 9 Ritzel M.W.L....Young J.D. (1997)
- Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2. (PubMed id 10455109)1, 2, 9 Loewen S.K....Young J.D. (1999)
- Hepatocyte nuclear factor-4alpha and bile acids regulate human concentrative nucleoside transporter-1 gene expression. (PubMed id 19228884)1, 9 Klein K....Eloranta J.J. (2009)
- Conserved residues F316 and G476 in the concentrative nucleoside transporter 1 (hCNT1) affect guanosine sensitivity and membrane expression, respectively. (PubMed id 15456697)1, 9 Lai Y....Unadkat J.D. (2005)
- Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations. (PubMed id 14978229)1, 9 Gray J.H....Giacomini K.M. (2004)
- Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5[Prime]-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug. (PubMed id 11353816)1, 9 Mata J.F....Pastor-Anglada M. (2001)
- Expression of the human concentrative nucleotide tran sporter 1 (hCNT1) gene correlates with clinical response in patients affected b y WaldenstrAPm's Macroglobulinemia (WM) and small lymphocytic lymphoma (SLL) und ergoing a combination treatment with 2-chloro-2'-deoxyadenosine (2-CdA) and Rit uximab. (PubMed id 19647871)1, 9 Rabascio C....Martinelli G. (2010)
- Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors. (PubMed id 15386342)1, 9 Farre X....Pastor-Anglada M. (2004)
- Immunocytochemical detection of hENT1 and hCNT1 in normal tissues, lung cancer cell lines, and NSCLC patient samples. (PubMed id 18600541)1, 9 Hubeek I....Peters G.J. (2008)
- Nucleoside transporter profiles in human pancreatic cancer cells: role of hCNT1 in 2',2'-difluorodeoxycytidine- induced cytotoxicity. (PubMed id 14581375)1, 9 Garcia-Manteiga J....Pastor-Anglada M. (2003)
|
External Searches for SLC28A1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC28A1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing SLC28A1 gene
(According to HUGE)
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Specialized Databases showing SLC28A1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for SLC28A1 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for SLC28A1 gene:
Search GeneIP for patents involving SLC28A1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SLC28A1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLC28A1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC28A1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC28A1 | | | OriGene Protein Over-expression Lysate for SLC28A1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLC28A1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC28A1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC28A1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SLC28A1 | | OriGene Custom Protein Services for SLC28A1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC28A1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC28A1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC28A1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC28A1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC28A1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC28A1 |
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| | | | Search Tocris compounds for SLC28A1 |
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 | | | SLC28A1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC28A1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for SLC28A1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC28A1 |
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