SLC27A6 Gene
protein-coding GIFtS: 57
GCID: GC05P127873
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solute carrier family 27 (fatty acid transporter), member...
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Aliases for SLC27A6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Solute Carrier Family 27 (Fatty Acid Transporter), Member 61 2 | | Very Long-Chain Acyl-CoA Synthetase Homolog 12 3 | | ACSVL21 2 3 | | FATP-62 3 | | FACVL21 2 3 | | VLCSH12 3 | | FATP61 2 | | HVLCS-H11 | | VLCS-H11 2 | | Long-Chain Fatty Acid Transport Protein 62 | | Fatty Acid Transport Protein 62 3 | | FATP13 | | Fatty-Acid-Coenzyme A Ligase, Very Long-Chain 22 3 | | EC 6.2.18 | | Solute Carrier Family 27 Member 62 3 | | EC 6.2.1.78 |
Export aliases for SLC27A6 gene to outside databasesPrevious GC identifers: GC00U990498 GC05P128212 GC05P128377 GC05P128328 GC05P123491 |
Summaries for SLC27A6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for SLC27A6: This gene encodes a member of the fatty acid transport protein family (FATP). FATPs are involved in the uptake oflong-chain fatty acids and have unique expression patterns. Alternatively spliced transcript variants encoding thesame protein have been found for this gene. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: S27A6_HUMAN, Q9Y2P4Function: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function asthe predominant fatty acid protein transporter in heart Gene Wiki entry for SLC27A6
|
Genomic Views for SLC27A6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SLC27A6 gene promoter: NF-1/L NF-1 AML1a COMP1 Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC27A6
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC27A6 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q23.3 Ensembl cytogenetic band: 5q23.3 HGNC cytogenetic band: 5q23.3SLC27A6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P127873: view genomic region
(about GC identifiers)
Start:
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127,873,706 bp from pter |
End:
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128,369,335 bp from pter |
Size:
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495,630 bases |
Orientation:
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plus strand |
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Proteins for SLC27A6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: S27A6_HUMAN, Q9Y2P4 (See
protein sequence)Recommended Name: Long-chain fatty acid transport protein 6 Size: 619 amino acids; 70112 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential). Cell membrane, sarcolemma (By similarity).Note=In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where itcolocalizes CD36 (By similarity)
Secondary accessions: Q6IAM5 Q7Z6E6 Q86YF6Explore the universe of human proteins at neXtProt for SLC27A6: NX_Q9Y2P4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y2P4 3 DME Specific Peptides for SLC27A6 (Q9Y2P4)
SLC27A6 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins (2 alternative transcripts):
NP_001017372.1 NP_054750.1 ENSEMBL proteins: ENSP00000421759 ENSP00000262462 ENSP00000378684 ENSP00000421024 Reactome Protein details: Q9Y2P4 Human Recombinant Protein Products for SLC27A6:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SLC27A6 for ontologies About GeneDecksing
SLC27A6 Antibody Products: Assay Products for SLC27A6: |
Protein
Domains / Families for SLC27A6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC27A6 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y2P4ProtoNet protein and cluster: Q9Y2P4 1 Blocks protein family: IPB000873 AMP-binding signature
UniProtKB/Swiss-Prot: S27A6_HUMAN, Q9Y2P4Similarity: Belongs to the ATP-dependent AMP-binding enzyme family |
Function for SLC27A6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: S27A6_HUMAN, Q9Y2P4Function: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function asthe predominant fatty acid protein transporter in heart Enzyme Numbers (IUBMB): EC 6.2.12 EC 6.2.1.72
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0004467 | long-chain fatty acid-CoA ligase activity |
TAS | 10471116 | | GO:0031957 | very long-chain fatty acid-CoA ligase activity |
IEA | -- |
SLC27A6 for ontologies About GeneDecksing
Phenotypes: 1 GenomeRNAi human phenotype for SLC27A6: Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC27A6 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC27A6 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC27A6 |
|
Pathways & Interactions for SLC27A6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | SLC-mediated transmembrane transport | | | 2 | PPAR signaling pathway | | | 3 | Transport of organic anions | | | 4 | Expression of FATP1 (SLC27A1) | |
Pathway sources See GeneCards unified pathways Show all pathways
4
Reactome Pathways for SLC27A6
1
Kegg Pathway (Kegg details for SLC27A6):
SLC27A6 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC27A6
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
 5/9 Interacting proteins for SLC27A6 (Q9Y2P42, 3 ENSP000002624624) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
SLC27A6 for ontologies About GeneDecksing
|
Drugs & Compounds for SLC27A6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SLC27A6 for compounds About GeneDecksing
Browse Tocris compounds for SLC27A6
9 HMDB Compounds for SLC27A6 About this table 3 Novoseek chemical compound relationships for SLC27A6 gene About this table
Search CenterWatch for drugs/clinical trials and news about SLC27A6 / S27A6 
|
Transcripts for SLC27A6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for SLC27A6 gene (2 alternative transcripts): NM_001017372.1 NM_014031.3 Unigene Cluster for SLC27A6: Solute carrier family 27 (fatty acid transporter), member 6 Hs.49765 [show with all ESTs]Unigene Representative Sequence: BC0419454 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000508645 ENST00000262462(uc003kuz.3) ENST00000395266(uc003kuy.3) ENST00000506176
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC27A6 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC27A6 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): SLC27A6 (NM_014031) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC27A6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC27A6  |
Additional cDNA sequence: AF064254.1 AK313456.1 AL833117.1 BC041945.1 BX537383.1 CR457129.1 5 DOTS entries: DT.210861 DT.100015562 DT.120881399 DT.120881424 DT.40255769 24/32 AceView cDNA sequences (see all 32): NM_014031 BX101154 AF064254 AA614135 AA469992 N98632 N69873 BC041945 C04812 W19745 CR457129 CD675567 BI769159 AI284588 AL833117 AA412064 BX537383 T19992 AI742933 AA249777 AI290597 BI600935 AI868081 BQ375251 GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SLC27A6 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | |
| SP1: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for SLC27A6
|
Expression for SLC27A6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC27A6 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TACTATATTT
 About this image See SLC27A6 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SLC27A6
SOURCE GeneReport for Unigene cluster: Hs.49765
UniProtKB/Swiss-Prot: S27A6_HUMAN, Q9Y2P4Tissue specificity: Strongly expressed in heart and localizes to cardiac myocytes. Expressed at moderate levels inplacenta, testis, and adrenal glands. Expressed at very low levels in kidney, bladder and uterus SABiosciences Expression via Pathway-Focused PCR Arrays including SLC27A6:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC27A6 Browse OriGene validated miRNA SYBR primer pairs
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| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC27A6 |
Orthologs for SLC27A6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for SLC27A6 gene from 6/17 species (see all 17) About this table
ENSEMBL Gene Tree for SLC27A6 (if available) TreeFam Gene Tree for SLC27A6 (if available)  |
Paralogs for SLC27A6 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for SLC27A6 gene
- SLC27A52 SLC27A22 SLC27A42 SLC27A12 SLC27A32
6 SIMAP similar genes for SLC27A6 using alignment to 2 protein entries: S27A6_HUMAN (see all proteins):SLC27A2 SLC27A3 SLC27A5 FLJ00336 SLC27A4 SLC27A1
SLC27A6 for paralogs About GeneDecksing
|
Genomic Variants for SLC27A6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 5 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC27A6 (127873706 - 128123706 bp, first 250kb of SLC27A6)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 4 variations for SLC27A6 2 CNVs: 93229 59232 2 Indels: 41314 46771  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC27A6 |
|
Disorders
/ Diseases for SLC27A6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC27A6 for disorders About GeneDecksing
OMIM gene information: 604196
OMIM disorders: --
8 diseases for SLC27A6: About MalaCardsdilated cardiomyopathy insulin resistance cardiomyopathy prostate cancer obesity prostatitis tuberculosis mycobacterium tuberculosis Human Genome Epidemiology (HuGE) Navigator: SLC27A6 (1 document) Export disorders for SLC27A6 gene to outside databases
|
Publications for SLC27A6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC27A6 gene, integrated from 9 sources (see all 29): (articles sorted by number of sources associating them with SLC27A6) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Characterization of a heart-specific fatty acid transport protein. (PubMed id 12556534)1, 2, 3 Gimeno R.E.... Stahl A. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein. (PubMed id 10479480)1, 3 Steinberg S.J.... Watkins P.A. (1999)
- A variant in the heart-specific fatty acid transport p rotein 6 is associated with lower fasting and postprandial TAG, blood pressure a nd left ventricular hypertrophy. (PubMed id 21920065)1 Auinger A....Schrezenmeir J. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Genetic variability of the fatty acid synthase pathwa y is not associated with prostate cancer risk in the European Prospective Inves tigation on Cancer (EPIC). (PubMed id 20965718)1 Campa D....Canzian F. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SLC27A6 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SLC27A6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC27A6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC27A6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for SLC27A6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC27A6 gene: Search GeneIP for patents involving SLC27A6
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for SLC27A6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
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