Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC27A6 Gene

Aliases for SLC27A6 Gene

  • Solute Carrier Family 27 Member 6 2 3 4
  • Solute Carrier Family 27 (Fatty Acid Transporter), Member 6 2 3 5
  • Fatty-Acid-Coenzyme A Ligase, Very Long-Chain 2 3 4
  • Very Long-Chain Acyl-CoA Synthetase Homolog 1 3 4
  • ACSVL2 3 4
  • FACVL2 3 4
  • Acyl-CoA Synthetase Very Long Chain Family, Member 2 3
  • Fatty Acid Transport Protein 6 4
  • Fatty-Acid-Coenzyme A Ligase 2
  • Very Long-Chain 2 2
  • EC 6.2.1.7 63
  • HVLCS-H1 4
  • EC 6.2.1 63
  • VLCS-H1 3
  • FATP-6 4
  • VLCSH1 4
  • FATP1 4
  • FATP6 3

External Ids for SLC27A6 Gene

Previous GeneCards Identifiers for SLC27A6 Gene

  • GC00U990498
  • GC05P128212
  • GC05P128377
  • GC05P128328
  • GC05P127873
  • GC05P123491

Summaries for SLC27A6 Gene

Entrez Gene Summary for SLC27A6 Gene

  • This gene encodes a member of the fatty acid transport protein family (FATP). FATPs are involved in the uptake of long-chain fatty acids and have unique expression patterns. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC27A6 Gene

SLC27A6 (Solute Carrier Family 27 Member 6) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and PPAR signaling pathway. GO annotations related to this gene include nucleotide binding and very long-chain fatty acid-CoA ligase activity. An important paralog of this gene is SLC27A1.

UniProtKB/Swiss-Prot for SLC27A6 Gene

  • Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart.

Gene Wiki entry for SLC27A6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC27A6 Gene

Genomics for SLC27A6 Gene

Regulatory Elements for SLC27A6 Gene

Promoters for SLC27A6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC27A6 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC27A6 Gene

Chromosome:
5
Start:
128,538,013 bp from pter
End:
129,033,642 bp from pter
Size:
495,630 bases
Orientation:
Plus strand

Genomic View for SLC27A6 Gene

Genes around SLC27A6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC27A6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC27A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC27A6 Gene

Proteins for SLC27A6 Gene

  • Protein details for SLC27A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2P4-S27A6_HUMAN
    Recommended name:
    Long-chain fatty acid transport protein 6
    Protein Accession:
    Q9Y2P4
    Secondary Accessions:
    • Q6IAM5
    • Q7Z6E6
    • Q86YF6

    Protein attributes for SLC27A6 Gene

    Size:
    619 amino acids
    Molecular mass:
    70112 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC27A6 Gene

Proteomics data for SLC27A6 Gene at MOPED

Selected DME Specific Peptides for SLC27A6 Gene

Post-translational modifications for SLC27A6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC27A6 Gene

Domains & Families for SLC27A6 Gene

Protein Domains for SLC27A6 Gene

Suggested Antigen Peptide Sequences for SLC27A6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2P4

UniProtKB/Swiss-Prot:

S27A6_HUMAN :
  • Belongs to the ATP-dependent AMP-binding enzyme family.
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with SLC27A6: view

Function for SLC27A6 Gene

Molecular function for SLC27A6 Gene

UniProtKB/Swiss-Prot Function:
Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart.

Enzyme Numbers (IUBMB) for SLC27A6 Gene

genes like me logo Genes that share phenotypes with SLC27A6: view

Animal Model Products

CRISPR Products

miRNA for SLC27A6 Gene

miRTarBase miRNAs that target SLC27A6

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC27A6 Gene

Localization for SLC27A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC27A6 Gene

Membrane; Multi-pass membrane protein. Cell membrane, sarcolemma. Note=In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where it colocalizes CD36. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC27A6 Gene COMPARTMENTS Subcellular localization image for SLC27A6 gene
Compartment Confidence
plasma membrane 5
mitochondrion 2
peroxisome 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for SLC27A6 Gene

Pathways & Interactions for SLC27A6 Gene

genes like me logo Genes that share pathways with SLC27A6: view

Interacting Proteins for SLC27A6 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000262462%0d%0a9606.ENSP00000348762%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000361007%0d%0a9606.ENSP00000377900%0d%0a9606.ENSP00000383900%0d%0a
Selected Interacting proteins: ENSP00000262462 Q9Y2P4-S27A6_HUMAN for SLC27A6 Gene via STRING I2D MINT

Gene Ontology (GO) - Biological Process for SLC27A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015909 long-chain fatty acid transport TAS --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC27A6: view

No data available for SIGNOR curated interactions for SLC27A6 Gene

Drugs & Compounds for SLC27A6 Gene

(5) Drugs for SLC27A6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 20
Stearic acid Experimental Pharma 0
Tridecanoic acid Experimental Pharma 0
arachidonic acid Experimental Nutra Activator 27

(7) Additional Compounds for SLC27A6 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
Pentadecanoic acid
  • N-Pentadecanoate
  • N-Pentadecanoic acid
  • N-Pentadecylate
  • N-Pentadecylic acid
  • Pentadecanoate
1002-84-2
genes like me logo Genes that share compounds with SLC27A6: view

Transcripts for SLC27A6 Gene

Unigene Clusters for SLC27A6 Gene

Solute carrier family 27 (fatty acid transporter), member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC27A6 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2:
SP3: - -
SP4: -
SP5: -
SP6: - -

Relevant External Links for SLC27A6 Gene

GeneLoc Exon Structure for
SLC27A6
ECgene alternative splicing isoforms for
SLC27A6

Expression for SLC27A6 Gene

mRNA expression in normal human tissues for SLC27A6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC27A6 Gene

This gene is overexpressed in Heart - Left Ventricle (x8.6), Esophagus - Muscularis (x5.7), Heart - Atrial Appendage (x5.2), and Adrenal Gland (x4.6).

Protein differential expression in normal tissues from HIPED for SLC27A6 Gene

This gene is overexpressed in Fetal heart (23.2), Retina (19.2), and Testis (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC27A6 Gene



SOURCE GeneReport for Unigene cluster for SLC27A6 Gene Hs.49765

mRNA Expression by UniProt/SwissProt for SLC27A6 Gene

Q9Y2P4-S27A6_HUMAN
Tissue specificity: Strongly expressed in heart and localizes to cardiac myocytes. Expressed at moderate levels in placenta, testis, and adrenal glands. Expressed at very low levels in kidney, bladder and uterus.
genes like me logo Genes that share expression patterns with SLC27A6: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for SLC27A6 Gene

Orthologs for SLC27A6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC27A6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC27A6 35
  • 99.25 (n)
  • 99.03 (a)
SLC27A6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC27A6 36
  • 74 (a)
OneToOne
SLC27A6 35
  • 83.98 (n)
  • 76.21 (a)
dog
(Canis familiaris)
Mammalia SLC27A6 35
  • 87.02 (n)
  • 83.36 (a)
SLC27A6 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc27a6 36
  • 78 (a)
OneToOne
Slc27a6 16
Slc27a6 35
  • 80.29 (n)
  • 78.35 (a)
rat
(Rattus norvegicus)
Mammalia Slc27a6 35
  • 81.48 (n)
  • 78.68 (a)
chicken
(Gallus gallus)
Aves SLC27A6 36
  • 67 (a)
OneToOne
SLC27A6 35
  • 72.11 (n)
  • 68.5 (a)
lizard
(Anolis carolinensis)
Reptilia SLC27A6 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9882 35
tropical clawed frog
(Silurana tropicalis)
Amphibia slc27a6 35
  • 69.41 (n)
  • 65.27 (a)
Str.16676 35
zebrafish
(Danio rerio)
Actinopterygii slc27a6 36
  • 55 (a)
OneToOne
LOC568883 35
  • 59.33 (n)
  • 53.18 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAT1 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for SLC27A6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC27A6 Gene

ENSEMBL:
Gene Tree for SLC27A6 (if available)
TreeFam:
Gene Tree for SLC27A6 (if available)

Paralogs for SLC27A6 Gene

Paralogs for SLC27A6 Gene

(6) SIMAP similar genes for SLC27A6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC27A6: view

Variants for SLC27A6 Gene

Sequence variations from dbSNP and Humsavar for SLC27A6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs2526247 - 128,966,192(+) ACTTC(G/T)TGCAG reference, missense
rs31273 -- 129,025,384(-) TCCCT(A/G)TATTT intron-variant
rs171795 -- 128,987,140(+) aatat(A/G)tatat intron-variant
rs181958 -- 128,977,146(+) AGCAA(A/G)TGTTC intron-variant
rs194459 -- 129,017,187(-) ctggc(A/C)cagta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC27A6 Gene

Variant ID Type Subtype PubMed ID
dgv6318n71 CNV Loss 21882294
esv2656691 CNV Deletion 23128226
nsv830485 CNV Gain 17160897
nsv819884 CNV Gain 19587683
dgv6319n71 CNV Loss 21882294
nsv882842 CNV Loss 21882294
esv274641 CNV Insertion 20981092
esv267726 CNV Insertion 20981092
nsv329438 CNV Insertion 16902084
nsv328601 CNV Insertion 16902084
dgv6320n71 CNV Loss 21882294
esv2730759 CNV Deletion 23290073
esv2730760 CNV Deletion 23290073
esv2407327 CNV Deletion 18987734
esv2730761 CNV Deletion 23290073
esv5198 CNV Deletion 18987735
nsv327282 CNV Loss 16902084
esv1008060 CNV Deletion 20482838
esv2730763 CNV Deletion 23290073
esv1641373 CNV Deletion 17803354
nsv329829 CNV Loss 16902084
nsv882846 CNV Loss 21882294
nsv4996 CNV Insertion 18451855
nsv882847 CNV Loss 21882294

Variation tolerance for SLC27A6 Gene

Residual Variation Intolerance Score: 83.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.65; 56.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC27A6 Gene

HapMap Linkage Disequilibrium report
SLC27A6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC27A6 Gene

Disorders for SLC27A6 Gene

Relevant External Links for SLC27A6

Genetic Association Database (GAD)
SLC27A6
Human Genome Epidemiology (HuGE) Navigator
SLC27A6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC27A6

No disorders were found for SLC27A6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC27A6 Gene

Publications for SLC27A6 Gene

  1. Characterization of a heart-specific fatty acid transport protein. (PMID: 12556534) Gimeno R.E. … Stahl A. (J. Biol. Chem. 2003) 2 3 4 67
  2. Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein. (PMID: 10479480) Steinberg S.J. … Watkins P.A. (Mol. Genet. Metab. 1999) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A variant in the heart-specific fatty acid transport protein 6 is associated with lower fasting and postprandial TAG, blood pressure and left ventricular hypertrophy. (PMID: 21920065) Auinger A. … Schrezenmeir J. (Br. J. Nutr. 2012) 3
  5. Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC). (PMID: 20965718) Campa D. … Canzian F. (Eur. J. Cancer 2011) 3

Products for SLC27A6 Gene

Sources for SLC27A6 Gene

Back to Top

Content