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SLC27A6 Gene

protein-coding   GIFtS: 62
GCID: GC05P127873

Solute Carrier Family 27 (Fatty Acid Transporter), Member...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 27 (Fatty Acid Transporter), Member 61 2     hVLCS-H12 3
Fatty Acid Transport Protein 62 3     Fatty-Acid-Coenzyme A Ligase1
Fatty-Acid-Coenzyme A Ligase, Very Long-Chain 22 3     Very Long-Chain 21
Solute Carrier Family 27 Member 62 3     FATP62
Very Long-Chain Acyl-CoA Synthetase Homolog 12 3     VLCS-H12
ACSVL22 3     Long-Chain Fatty Acid Transport Protein 62
FACVL22 3     FATP13
FATP-62 3     EC 6.2.18
VLCSH12 3     EC 6.2.1.78

External Ids:    HGNC: 110001   Entrez Gene: 289652   Ensembl: ENSG000001133967   OMIM: 6041965   UniProtKB: Q9Y2P43   

Export aliases for SLC27A6 gene to outside databases

Previous GC identifers: GC00U990498 GC05P128212 GC05P128377 GC05P128328 GC05P123491


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC27A6 Gene:
This gene encodes a member of the fatty acid transport protein family (FATP). FATPs are involved in the uptake of
long-chain fatty acids and have unique expression patterns. Alternatively spliced transcript variants encoding
the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for SLC27A6 Gene:
SLC27A6 (solute carrier family 27 (fatty acid transporter), member 6) is a protein-coding gene. GO annotations related to this gene include very long-chain fatty acid-CoA ligase activity and nucleotide binding. An important paralog of this gene is SLC27A5.

UniProtKB/Swiss-Prot: S27A6_HUMAN, Q9Y2P4
Function: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to
function as the predominant fatty acid protein transporter in heart

Gene Wiki entry for SLC27A6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC27A6 gene promoter:
         NF-1/L   NF-1   AML1a   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC27A6 promoter sequence
   Search Chromatin IP Primers for SLC27A6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC27A6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.3   Ensembl cytogenetic band:  5q23.3   HGNC cytogenetic band: 5q23.3

SLC27A6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC27A6 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P127873:  view genomic region     (about GC identifiers)

Start:
127,873,706 bp from pter      End:
128,369,335 bp from pter
Size:
495,630 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S27A6_HUMAN, Q9Y2P4 (See protein sequence)
Recommended Name: Long-chain fatty acid transport protein 6  
Size: 619 amino acids; 70112 Da
Secondary accessions: Q6IAM5 Q7Z6E6 Q86YF6

Explore the universe of human proteins at neXtProt for SLC27A6: NX_Q9Y2P4

Explore proteomics data for SLC27A6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for SLC27A6 (Q9Y2P4)
     RWKGENV  QYIGELCRYL  TSGTTGLPKA 


    See SLC27A6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001017372.1  NP_054750.1  

    ENSEMBL proteins: 
     ENSP00000421759   ENSP00000262462   ENSP00000378684   ENSP00000421024  
    Reactome Protein details: Q9Y2P4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers
    ACS: Acyl-CoA synthetase family

    IUPHAR Guide to PHARMACOLOGY protein family classification: Fatty acid transport protein 6
    SLC27 family of fatty acid transporters

    3 InterPro protein domains:
     IPR025110 AMP-bd_C
     IPR020845 AMP-binding_CS
     IPR000873 AMP-dep_Synth/Lig

    Graphical View of Domain Structure for InterPro Entry Q9Y2P4

    ProtoNet protein and cluster: Q9Y2P4

    1 Blocks protein domain: IPB000873 AMP-binding signature

    UniProtKB/Swiss-Prot: S27A6_HUMAN, Q9Y2P4
    Similarity: Belongs to the ATP-dependent AMP-binding enzyme family


    Find genes that share domains with SLC27A6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S27A6_HUMAN, Q9Y2P4
    Function: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to
    function as the predominant fatty acid protein transporter in heart

         Enzyme Numbers (IUBMB): EC 6.2.12 EC 6.2.1.72

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003824catalytic activity ----
    GO:0004467long-chain fatty acid-CoA ligase activity TAS10471116
    GO:0031957very long-chain fatty acid-CoA ligase activity IEA--
         
    Find genes that share ontologies with SLC27A6           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC27A6:
     Decreased cilium length after  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC27A6
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S27A6_HUMAN, Q9Y2P4: Membrane; Multi-pass membrane protein (Potential). Cell membrane, sarcolemma (By
    similarity). Note=In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels
    where it colocalizes CD36 (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    peroxisome2
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0042383sarcolemma IEA--

    Find genes that share ontologies with SLC27A6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC27A6 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transmembrane transport of small molecules0.47
    2Transport of vitamins, nucleosides, and related molecules
    Transport of vitamins, nucleosides, and related molecules
    Transport of fatty acids0.00
    3PPAR signaling pathway
    PPAR signaling pathway


    Find genes that share SuperPaths with SLC27A6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC27A6
        Transport of fatty acids


    1 Kegg Pathway  (Kegg details for SLC27A6):
        PPAR signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC27A6: 
              Fatty Acid Metabolism in human mouse rat
              PPAR Targets in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SLC27A6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SLC27A6 (Q9Y2P42, 3 ENSP000002624624) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNB2L1P632442, 3, ENSP000003660134MINT-65801 I2D: score=4 STRING: ENSP00000366013
    CHD3Q128732, 3MINT-65804 I2D: score=4 
    CUTCQ9NTM92, 3MINT-65803 I2D: score=4 
    TNFRSF10CO147982, 3MINT-65800 I2D: score=4 
    VIMP086702, 3MINT-65802 I2D: score=4 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000038very long-chain fatty acid metabolic process TAS10471116
    GO:0001676long-chain fatty acid metabolic process TAS10471116
    GO:0008152metabolic process ----
    GO:0015909long-chain fatty acid transport TAS--
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with SLC27A6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC27A6 (S27A6)

    9 HMDB Compounds for SLC27A6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Arachidic acidArachate (see all 10)506-30-9--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    Heptadecanoic acidHeptadecanoate (see all 16)506-12-7--
    Heptadecanoyl CoAHeptadecanoyl coenzyme A (see all 19)3546-17-6--
    Myristic acid1-Tridecanecarboxylate (see all 15)544-63-8--
    Palmitic acidHexaectylic acid (see all 45)57-10-3--
    Pentadecanoic acidPentadecanoate (see all 8)1002-84-2--
    Stearic acid1-Heptadecanecarboxylate (see all 12)57-11-4--
    Tridecanoic acid(S)-2-Aminotridecanoate (see all 12)638-53-9--

    3 Novoseek inferred chemical compound relationships for SLC27A6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty acid 69.5 30 17164224 (3), 19527715 (2), 16611988 (2), 17023713 (1) (see all 11)
    triacylglycerol 54.8 2 17164224 (2)
    lipid 22 2 18269178 (2)



    Find genes that share compounds with SLC27A6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC27A6 gene (2 alternative transcripts): 
    NM_001017372.1  NM_014031.3  

    Unigene Cluster for SLC27A6:

    Solute carrier family 27 (fatty acid transporter), member 6
    Hs.49765  [show with all ESTs]
    Unigene Representative Sequence: BC041945
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508645 ENST00000262462(uc003kuz.3) ENST00000395266(uc003kuy.3)
    ENST00000506176
    miRNA
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    Additional mRNA sequence: 

    AF064254.1 AK313456.1 AL833117.1 BC041945.1 BX537383.1 CR457129.1 

    5 DOTS entries:

    DT.210861  DT.100015562  DT.120881399  DT.120881424  DT.40255769 

    Selected AceView cDNA sequences (see all 32):

    AF064254 AA469992 NM_014031 AA614135 N98632 BX101154 BI769159 C04812 
    BC041945 W19745 AI742933 CR457129 AI284588 AA412064 AL833117 T19992 
    N69873 BX537383 CD675567 BI600935 AA249777 AI290597 AI868081 BQ375251 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC27A6 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                                -                                                                                             
    SP2:                                                                                                                              
    SP3:                          -     -                                                                                             
    SP4:                          -                                                                                                   
    SP5:                          -                                                                                                   


    ECgene alternative splicing isoforms for SLC27A6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC27A6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTATATTT
    SLC27A6 Expression
    About this image


    SLC27A6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Pre-Sertoli Cells Testis Cord
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced cells
     
     Kidney (Urinary System)
             Metanephros
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    SLC27A6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC27A6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.49765

    UniProtKB/Swiss-Prot: S27A6_HUMAN, Q9Y2P4
    Tissue specificity: Strongly expressed in heart and localizes to cardiac myocytes. Expressed at moderate levels in
    placenta, testis, and adrenal glands. Expressed at very low levels in kidney, bladder and uterus

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC27A6: 
              Fatty Acid Metabolism in human mouse rat
              PPAR Targets in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC27A6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC27A6 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc27a61 , 5 solute carrier family 27 (fatty acid transporter), more1, 5 80.29(n)1
    78.35(a)1
      18 (33.71 cM)5
    2255791  NM_001081072.11  NP_001074541.11 
     585562575 
    chicken
    (Gallus gallus)
    Aves SLC27A61 solute carrier family 27 (fatty acid transporter), more 72.11(n)
    68.5(a)
      769933  XM_001233247.2  XP_001233248.2 
    lizard
    (Anolis carolinensis)
    Reptilia SLC27A66
    solute carrier family 27 (fatty acid transporter),...
    66(a)
    1 ↔ 1
    2(30391793-30446104)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.98822 Xenopus laevis transcribed sequence with weak similarity more 76.03(n)    BJ029165.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5688831 long-chain fatty acid transport protein 6-like 59.33(n)
    53.18(a)
      568883  XM_003199319.2  XP_003199367.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FAT16
    Very long chain fatty acyl-CoA synthetase and long...
    29(a)
    1 → many
    II(318266-320275) YBR041W


    ENSEMBL Gene Tree for SLC27A6 (if available)
    TreeFam Gene Tree for SLC27A6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC27A6 gene
    SLC27A52  SLC27A22  SLC27A42  SLC27A12  SLC27A32  
    6 SIMAP similar genes for SLC27A6 using alignment to 2 protein entries:     S27A6_HUMAN (see all proteins):
    SLC27A2    SLC27A3    SLC27A5    FLJ00336    SLC27A4    SLC27A1

    Find genes that share paralogs with SLC27A6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC27A6 (see all 1673)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs25775311,2
    C,F,O,A,H--128299279(+) GATTAC/TGTCTT 2 -- us2k135Minor allele frequency- T:0.31NS EA NA WA CSA 2934
    rs105200261,2
    C,F,H--128299378(+) CAAACA/TAGCTC 2 -- us2k117Minor allele frequency- T:0.15NS EA NA CSA WA 1078
    rs100422561,2
    C,F,H--128299490(+) AATAAG/ATGCAG 2 -- us2k112Minor allele frequency- A:0.13NA NS EA WA 886
    rs1154828941,2
    C,F--128299515(+) TGCCAC/TGCCTA 2 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1447515201,2
    C--128299616(+) TGTTCA/GTTAAA 2 -- us2k10--------
    rs1909320141,2
    --128299693(+) GCTTTC/TCAAGT 2 -- us2k10--------
    rs25775321,2
    C,F,A,H--128299709(+) ACTAAT/CGTTTT 2 -- us2k1 tfbs37Minor allele frequency- C:0.19NA WA EA 366
    rs1838804311,2
    --128299804(+) AAGCAA/TTTTTT 2 -- us2k10--------
    rs25775331,2
    C,F,O,H--128299914(+) AGCTCG/ATCTTT 2 -- us2k122Minor allele frequency- A:0.16EA NA NS WA CSA 3316
    rs1871788121,2
    --128299923(+) TTGGAA/TTTATC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC27A6 (127873706 - 128123706 bp, first 250kb of SLC27A6)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLC27A6 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1641373CNV Deletion17803354
    esv5198CNV Deletion18987735
    esv2730760CNV Deletion23290073
    esv1008060CNV Deletion20482838
    esv2656691CNV Deletion23128226
    esv2730763CNV Deletion23290073
    esv2407327CNV Deletion18987734
    esv2730761CNV Deletion23290073
    esv2730759CNV Deletion23290073
    esv274641CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC27A6
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC27A6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604196    OMIM disorders: --


    Find genes that share disorders with SLC27A6           About GenesLikeMe

    Genetic Association Database (GAD): SLC27A6
    Human Genome Epidemiology (HuGE) Navigator: SLC27A6 (1 document)

    Export disorders for SLC27A6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC27A6 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with SLC27A6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a heart-specific fatty acid transport protein. (PubMed id 12556534)1, 2, 3 Gimeno R.E.... Stahl A. (J. Biol. Chem. 2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein. (PubMed id 10479480)1, 3 Steinberg S.J.... Watkins P.A. (Mol. Genet. Metab. 1999)
    4. A variant in the heart-specific fatty acid transport protein 6 is associated with lower fasting and postprandial TAG, blood pressure and left ventricular hypertrophy. (PubMed id 21920065)1 Auinger A....Schrezenmeir J. (Br. J. Nutr. 2012)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC). (PubMed id 20965718)1 Campa D....Canzian F. (Eur. J. Cancer 2011)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    8. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)
    9. Framingham Heart Study genome-wide association: results for pulmonary function measures. (PubMed id 17903307)4 Wilk J.B....O'Connor G.T. (BMC Med. Genet. 2007)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 28965 HGNC: 11000 AceView: SLC27A6 Ensembl:ENSG00000113396 euGenes: HUgn28965
    ECgene: SLC27A6 Kegg: 28965 H-InvDB: SLC27A6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC27A6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC27A6 gene:
    Search GeneIP for patents involving SLC27A6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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