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Aliases for SLC27A6 Gene

Aliases for SLC27A6 Gene

  • Solute Carrier Family 27 Member 6 2 3 4 5
  • Fatty-Acid-Coenzyme A Ligase, Very Long-Chain 2 2 3 4
  • Solute Carrier Family 27 (Fatty Acid Transporter), Member 6 2 3
  • Very Long-Chain Acyl-CoA Synthetase Homolog 1 3 4
  • ACSVL2 3 4
  • FACVL2 3 4
  • Acyl-CoA Synthetase Very Long Chain Family, Member 2 3
  • Long-Chain Fatty Acid Transport Protein 6 3
  • Fatty Acid Transport Protein 6 4
  • EC 58
  • HVLCS-H1 4
  • EC 6.2.1 58
  • VLCS-H1 3
  • FATP-6 4
  • VLCSH1 4
  • FATP1 4
  • FATP6 3

External Ids for SLC27A6 Gene

Previous GeneCards Identifiers for SLC27A6 Gene

  • GC00U990498
  • GC05P128212
  • GC05P128377
  • GC05P128328
  • GC05P127873
  • GC05P123491

Summaries for SLC27A6 Gene

Entrez Gene Summary for SLC27A6 Gene

  • This gene encodes a member of the fatty acid transport protein family (FATP). FATPs are involved in the uptake of long-chain fatty acids and have unique expression patterns. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC27A6 Gene

SLC27A6 (Solute Carrier Family 27 Member 6) is a Protein Coding gene. Among its related pathways are Transport of vitamins, nucleosides, and related molecules and Insulin resistance. GO annotations related to this gene include nucleotide binding and very long-chain fatty acid-CoA ligase activity. An important paralog of this gene is SLC27A2.

UniProtKB/Swiss-Prot for SLC27A6 Gene

  • Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart.

Gene Wiki entry for SLC27A6 Gene

Additional gene information for SLC27A6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC27A6 Gene

Genomics for SLC27A6 Gene

Regulatory Elements for SLC27A6 Gene

Enhancers for SLC27A6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H129093 1.1 ENCODE 14.9 +556.9 556901 2.4 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF416 SLC27A6 ISOC1 MIR4633
GH05H128966 0.8 ENCODE 19.1 +427.5 427450 0.2 KLF1 ATF1 ETV1 MAX E2F1 ZFHX2 CTBP1 POLR2A ZNF600 PRDM10 SLC27A6 LOC102723638 GC05P128856
GH05H128949 0.4 ENCODE 20.5 +412.3 412287 0.9 ATF2 SLC27A6 LOC102723638 GC05P128856
GH05H128762 0.4 ENCODE 12.5 +225.3 225278 1.7 ZNF202 SLC27A6 GC05M128711 GC05P128856
GH05H129098 0.6 Ensembl 8.2 +561.0 560988 0.8 TAL1 CEBPB EBF1 DPF2 ZNF398 TCF12 PRDM6 GATA3 IKZF1 PRDM1 ISOC1 SLC27A6 MIR4633 LOC102723654
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC27A6 on UCSC Golden Path with GeneCards custom track

Promoters for SLC27A6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000186593 -13 2401 SIN3A FEZF1 GLI4 GLIS2 ZNF302 ZNF202 SP3 ZNF610 ZSCAN16 GLIS1

Genomic Locations for SLC27A6 Gene

Genomic Locations for SLC27A6 Gene
495,630 bases
Plus strand

Genomic View for SLC27A6 Gene

Genes around SLC27A6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC27A6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC27A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC27A6 Gene

Proteins for SLC27A6 Gene

  • Protein details for SLC27A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Long-chain fatty acid transport protein 6
    Protein Accession:
    Secondary Accessions:
    • Q6IAM5
    • Q7Z6E6
    • Q86YF6

    Protein attributes for SLC27A6 Gene

    619 amino acids
    Molecular mass:
    70112 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC27A6 Gene

Selected DME Specific Peptides for SLC27A6 Gene


Post-translational modifications for SLC27A6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC27A6 Gene

Domains & Families for SLC27A6 Gene

Gene Families for SLC27A6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC27A6 Gene

Suggested Antigen Peptide Sequences for SLC27A6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ATP-dependent AMP-binding enzyme family.
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with SLC27A6: view

Function for SLC27A6 Gene

Molecular function for SLC27A6 Gene

UniProtKB/Swiss-Prot Function:
Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart.

Enzyme Numbers (IUBMB) for SLC27A6 Gene

Gene Ontology (GO) - Molecular Function for SLC27A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003824 catalytic activity IEA --
GO:0004467 long-chain fatty acid-CoA ligase activity TAS,IEA --
GO:0015245 fatty acid transporter activity TAS --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with SLC27A6: view
genes like me logo Genes that share phenotypes with SLC27A6: view

Animal Model Products

miRNA for SLC27A6 Gene

miRTarBase miRNAs that target SLC27A6

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC27A6 Gene

Localization for SLC27A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC27A6 Gene

Membrane; Multi-pass membrane protein. Cell membrane, sarcolemma. Note=In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where it colocalizes CD36. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC27A6 gene
Compartment Confidence
plasma membrane 5
peroxisome 3
mitochondrion 2
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC27A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0042383 sarcolemma IEA --
genes like me logo Genes that share ontologies with SLC27A6: view

Pathways & Interactions for SLC27A6 Gene

genes like me logo Genes that share pathways with SLC27A6: view

Gene Ontology (GO) - Biological Process for SLC27A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000038 very long-chain fatty acid metabolic process TAS 10471116
GO:0001676 long-chain fatty acid metabolic process IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with SLC27A6: view

No data available for SIGNOR curated interactions for SLC27A6 Gene

Drugs & Compounds for SLC27A6 Gene

(5) Drugs for SLC27A6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Myristic acid Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22
Stearic acid Experimental Pharma 0
Tridecanoic acid Experimental Pharma 0
arachidonic acid Experimental Nutra Activator 32

(7) Additional Compounds for SLC27A6 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
Pentadecanoic acid
  • N-Pentadecanoate
  • N-Pentadecanoic acid
  • N-Pentadecylate
  • N-Pentadecylic acid
  • Pentadecanoate
genes like me logo Genes that share compounds with SLC27A6: view

Transcripts for SLC27A6 Gene

Unigene Clusters for SLC27A6 Gene

Solute carrier family 27 (fatty acid transporter), member 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC27A6 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP3: - -
SP4: -
SP5: -
SP6: - -

Relevant External Links for SLC27A6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC27A6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC27A6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC27A6 Gene

This gene is overexpressed in Heart - Left Ventricle (x8.6), Esophagus - Muscularis (x5.7), Heart - Atrial Appendage (x5.2), and Adrenal Gland (x4.6).

Protein differential expression in normal tissues from HIPED for SLC27A6 Gene

This gene is overexpressed in Fetal heart (23.2), Retina (19.2), and Testis (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC27A6 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC27A6 Gene:


SOURCE GeneReport for Unigene cluster for SLC27A6 Gene:


mRNA Expression by UniProt/SwissProt for SLC27A6 Gene:

Tissue specificity: Strongly expressed in heart and localizes to cardiac myocytes. Expressed at moderate levels in placenta, testis, and adrenal glands. Expressed at very low levels in kidney, bladder and uterus.

Evidence on tissue expression from TISSUES for SLC27A6 Gene

  • Liver(4.3)
  • Nervous system(4.2)
  • Heart(2.6)
  • Muscle(2.6)
genes like me logo Genes that share expression patterns with SLC27A6: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC27A6 Gene

Orthologs for SLC27A6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC27A6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC27A6 33 34
  • 99.25 (n)
(Canis familiaris)
Mammalia SLC27A6 33 34
  • 87.02 (n)
(Bos Taurus)
Mammalia SLC27A6 33 34
  • 83.98 (n)
(Rattus norvegicus)
Mammalia Slc27a6 33
  • 81.48 (n)
(Mus musculus)
Mammalia Slc27a6 33 16 34
  • 80.29 (n)
(Gallus gallus)
Aves SLC27A6 33 34
  • 72.11 (n)
(Anolis carolinensis)
Reptilia SLC27A6 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc27a6 33
  • 69.41 (n)
Str.16676 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.9882 33
(Danio rerio)
Actinopterygii LOC568883 33
  • 59.33 (n)
slc27a6 34
  • 55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAT1 34
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
Species where no ortholog for SLC27A6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC27A6 Gene

Gene Tree for SLC27A6 (if available)
Gene Tree for SLC27A6 (if available)

Paralogs for SLC27A6 Gene

Paralogs for SLC27A6 Gene

(6) SIMAP similar genes for SLC27A6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC27A6: view

Variants for SLC27A6 Gene

Sequence variations from dbSNP and Humsavar for SLC27A6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000141099 -- 129,019,436(+) CTCGG(-/A)AAAAA intron-variant
rs1000149973 -- 129,006,174(+) CCTCC(A/G)TTCAC intron-variant
rs1000218825 -- 129,007,455(+) AAAAA(A/T)AAAAA intron-variant
rs1000240653 -- 128,995,480(+) CAATG(A/T)CAAAG intron-variant
rs1000281598 -- 129,024,142(+) AATTT(C/T)AATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC27A6 Gene

Variant ID Type Subtype PubMed ID
nsv958295 CNV deletion 24416366
nsv830485 CNV gain 17160897
nsv819884 CNV gain 19587683
nsv599701 CNV gain 21841781
nsv4996 CNV insertion 18451855
nsv329829 CNV deletion 16902084
nsv329438 CNV insertion 16902084
nsv328601 CNV insertion 16902084
nsv327282 CNV deletion 16902084
nsv1121650 CNV deletion 24896259
nsv1074331 CNV deletion 25765185
nsv1015525 CNV loss 25217958
esv5198 CNV loss 18987735
esv3606743 CNV gain 21293372
esv3606741 CNV loss 21293372
esv3606739 CNV gain 21293372
esv3606738 CNV loss 21293372
esv3324011 CNV insertion 20981092
esv2730763 CNV deletion 23290073
esv2730761 CNV deletion 23290073
esv2730760 CNV deletion 23290073
esv2730759 CNV deletion 23290073
esv2656691 CNV deletion 23128226
esv2407327 CNV deletion 18987734
esv1641373 CNV deletion 17803354
esv1008060 CNV deletion 20482838

Variation tolerance for SLC27A6 Gene

Residual Variation Intolerance Score: 83.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.65; 56.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC27A6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC27A6 Gene

Disorders for SLC27A6 Gene

Relevant External Links for SLC27A6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC27A6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC27A6 Gene

Publications for SLC27A6 Gene

  1. Characterization of a heart-specific fatty acid transport protein. (PMID: 12556534) Gimeno RE … Stahl A (The Journal of biological chemistry 2003) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein. (PMID: 10479480) Steinberg SJ … Watkins PA (Molecular genetics and metabolism 1999) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for SLC27A6 Gene

Sources for SLC27A6 Gene

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