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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC27A5 Gene

protein-coding   GIFtS: 60
GCID: GC19M059009

solute carrier family 27 (fatty acid transporter), member...
 Explore 6 diseases affiliated with
SLC27A5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC27A5    

Aliases
for SLC27A5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 27 (Fatty Acid Transporter), Member 51 2     Solute Carrier Family 27 Member 52 3
FATP51 2 3 5     Very Long-Chain Acyl-CoA Synthetase Homolog 22 3
VLACSR1 2 3 5     Very Long-Chain Acyl-CoA Synthetase-Related Protein2 3
VLCSH21 2 3 5     BACS2 3
ACSB1 2 3     BAL2 3
ACSVL61 2 3     FATP-52 3
FACVL31 2 3     VLACS-Related1
VLCS-H21 2 3     BA-CoA Ligase2 3
Bile Acid-CoA Ligase2 3     FLJ229871
Cholate--CoA Ligase2 3     Bile Acyl-CoA Synthetase2
Fatty Acid Transport Protein 52 3     EC 6.2.1.73
Fatty-Acid-Coenzyme A Ligase, Very Long-Chain 32 3     

External Ids:    HGNC: 109991   Entrez Gene: 109982   Ensembl: ENSG000000838077   OMIM: 6033145   UniProtKB: Q9Y2P53   

Export aliases for SLC27A5 gene to outside databases

Previous GC identifers: GC19U990162 GC19M059463 GC19M063666 GC19M063701 GC19M055319


Summaries
for SLC27A5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC27A5:
The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of
activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with
endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid
synthesis rather than in degradation. This gene has a mouse ortholog. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: S27A5_HUMAN, Q9Y2P5
Function: Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation
of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to
their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In
vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid
deriving from the de novo synthesis from cholesterol

Gene Wiki entry for SLC27A5


Genomic Views
for SLC27A5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC27A5 gene promoter:
         COUP-TF1   COUP-TF   ARP-1   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC27A5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC27A5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC27A5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

SLC27A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC27A5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M059009:  view genomic region     (about GC identifiers)

Start:
 59,009,700 bp from pter      End:
 59,023,432 bp from pter
Size:
 13,733 bases      Orientation:
 minus strand

Proteins
for SLC27A5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: S27A5_HUMAN, Q9Y2P5 (See protein sequence)
Recommended Name: Bile acyl-CoA synthetase  
Size: 690 amino acids; 75385 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: B3KVP6

Explore the universe of human proteins at neXtProt for SLC27A5: NX_Q9Y2P5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y2P5

    • SLC27A5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036386.1  
    ENSEMBL proteins: 
     ENSP00000263093  
    Reactome Protein details: Q9Y2P5
    Human Recombinant Protein Products: 
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    Uscn Proteins for SLC27A5

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA10479480
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005792microsome ----
    GO:0009925basal plasma membrane IEA--
    GO:0030176integral to endoplasmic reticulum membrane IDA11980911


    SLC27A5 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SLC27A5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC27A5 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000873 AMP-dep_Synth/Lig
     IPR020845 AMP-binding_CS

    Graphical View of Domain Structure for InterPro Entry Q9Y2P5

    ProtoNet protein and cluster: Q9Y2P5

    1 Blocks protein family: IPB000873 AMP-binding signature

    UniProtKB/Swiss-Prot: S27A5_HUMAN, Q9Y2P5
    Similarity: Belongs to the ATP-dependent AMP-binding enzyme family


    Function
    for SLC27A5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: S27A5_HUMAN, Q9Y2P5
    Function: Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation
    of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to
    their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In
    vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid
    deriving from the de novo synthesis from cholesterol
    Catalytic activity: ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA
    Catalytic activity: ATP + (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-oate + CoA = AMP + diphosphate
    + (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA

    Enzyme Number (IUBMB): EC 6.2.1.71

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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0015245fatty acid transporter activity IEA--
    GO:0031957very long-chain fatty acid-CoA ligase activity IDA11980911
    GO:0032403protein complex binding IEA--
    GO:0047747cholate-CoA ligase activity IEA--


    SLC27A5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SLC27A5:
     Lamellipodia and high actin ra 

    Animal Models:
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slc27a5):
     adipose tissue  behavior/neurological  growth/size  homeostasis/metabolism  liver/biliary system 

    SLC27A5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLC27A5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of bile acids and bile salts
    		Synthesis of bile acids and bile salts1.00
    		Synthesis of bile acids and bile salts via 24-hydroxycholesterol0.53
    		Primary bile acid biosynthesis0.84
    		bile acid biosynthesis, neutral pathway0.52
    		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol0.79
    		Recycling of bile acids and salts0.11
    		Bile acid and bile salt metabolism0.70
    2Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    		Metabolic pathways0.38
    3Bile secretion
    		Bile secretion1.00
    4PPAR signaling pathway
    		PPAR signaling pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for SLC27A5 
        bile acid biosynthesis, neutral pathway

    5/7        Reactome Pathways for SLC27A5 (see all 7)
        Synthesis of bile acids and bile salts via 24-hydroxycholesterol
    Bile acid and bile salt metabolism
    Metabolism
    Synthesis of bile acids and bile salts
    Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol


    4         Kegg Pathways  (Kegg details for SLC27A5):
        Primary bile acid biosynthesis
    Metabolic pathways
    PPAR signaling pathway
    Bile secretion


    SLC27A5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC27A5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for SLC27A5 (Q9Y2P53 ENSP000002630934) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSF4Q9ULV53, ENSP000002640094I2D: score=1 STRING: ENSP00000264009
    ACSL1P331213I2D: score=1 
    ALBENSP000002958974STRING: ENSP00000295897
    AMACRENSP000003344244STRING: ENSP00000334424
    BAATENSP000002594074STRING: ENSP00000259407
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000038very long-chain fatty acid metabolic process IDA10479480
    GO:0006642triglyceride mobilization IEA--
    GO:0006699bile acid biosynthetic process TAS--
    GO:0008206bile acid metabolic process TAS--
    GO:0015721bile acid and bile salt transport TAS--


    SLC27A5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC27A5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC27A5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SLC27A5

    10/45 HMDB Compounds for SLC27A5 (see all 45)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    3a,7a,12a-Trihydroxy-5b-cholestanoic acid3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate (see all 7)33964-75-9--
    3a,7a,12a-Trihydroxy-5b-cholestanoyl-CoA3a,7a,12a-Trihydroxy-5b-cholestan-26-oyl-CoA (see all 28)57458-60-3--
    2 Novoseek chemical compound relationships for SLC27A5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    taurine 56.5 1 12754200 (1)
    fatty acid 41 3 19054139 (1), 9642112 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC27A5 / S27A5 

    Transcripts
    for SLC27A5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC27A5 gene: 
    NM_012254.2  

    Unigene Cluster for SLC27A5:

    Solute carrier family 27 (fatty acid transporter), member 5
    Hs.292177  [show with all ESTs]
    Unigene Representative Sequence: AB208931
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000263093(uc002qtb.3 uc002qtc.2)

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    Inhib. RNA
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    Additional cDNA sequence: 

    AB208931.1 AF064255.1 AK026640.1 AK123036.1 AK298446.1 

    12 DOTS entries:

    DT.99927231  DT.86839376  DT.100764620  DT.121457190  DT.410504  DT.95342810  DT.97837645  DT.121457183 
    DT.97802875  DT.91935988  DT.75127190  DT.97839687 

    24/59 AceView cDNA sequences (see all 59):

    AK123036 BX103174 BF508128 BX427564 CB156985 CB163817 AA401562 AK026640 
    BU528534 AF064255 BU568143 AA745947 BX427563 BP368877 CB163803 AI073500 
    BM707896 BU688212 BM707763 AI240480 CB122260 BG284153 BV183863 AL543368 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC27A5    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c
    SP1:              -                                         -     -                                       
    SP2:                                                                                                      
    SP3:                                                                                                      
    SP4:                                                                                -                     
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for SLC27A5

    Expression
    for SLC27A5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC27A5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGGTCACCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SLC27A5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC27A5

    SOURCE GeneReport for Unigene cluster: Hs.292177

    UniProtKB/Swiss-Prot: S27A5_HUMAN, Q9Y2P5
    Tissue specificity: Predominantly expressed in liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including SLC27A5: 
              Fatty Acid Metabolism in human mouse rat
              Fatty Liver in human mouse rat
              PPAR Targets in human mouse rat

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    In Situ
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    Orthologs
    for SLC27A5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC27A5 gene from 3/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLC27A56
    		 --
    		 40(a)
    		 1 ↔ 1
    		 Un(34717986-34725318)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 4)    		 --
    		 54(a)
    52(a)
    (see all 4)    		 1 ↔ many
    1 ↔ many
    (see all 4)    		 6(78749520-78756129)
    6(78733115-78740779)
    soybean
    (Glycine max)    		 eudicotyledons Gma.67802 Transcribed sequence with moderate similarity to protein more 85.33(n)  


    ENSEMBL Gene Tree for SLC27A5 (if available)
    TreeFam Gene Tree for SLC27A5 (if available) 

    Paralogs
    for SLC27A5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC27A5 gene
    SLC27A22  SLC27A42  SLC27A12  SLC27A32  SLC27A62  
    6 SIMAP similar genes for SLC27A5 using alignment to 3 protein entries:     S27A5_HUMAN (see all proteins):
    SLC27A2    SLC27A6    SLC27A3    FLJ00336    SLC27A4    SLC27A1

    SLC27A5 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC27A5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/366 NCBI SNPs in SLC27A5 are shown (see all 366)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1825942161,2
    		--59009211(+) TAGGCA/TTCGGG 1 -- ds50010--------
    rs1871931701,2
    		--59009214(+) GCTTCA/GGGTAG 1 -- ds50010--------
    rs1410371161,2
    		--59009221(+) GTAGCA/CGGTCC 1 -- ds50010--------
    rs1150545391,2
    		F,--59009230(+) CCAACT/CCCTGA 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1502239481,2
    		--59009265(+) GAGGCC/TTCTGC 1 -- ds50010--------
    rs1387766881,2
    		--59009320(+) CGTGCA/CGTTCA 1 -- ds50010--------
    rs1114063121,2
    		--59009495(+) GATGAG/CAATCA 1 -- ds50011Minor allele frequency- C:0.50CSA 2
    rs1907378531,2
    		--59009532(+) AGCTGC/TGAGGC 1 -- ds50010--------
    rs104101031,2
    		C,H--59009604(+) AGGTTC/TTTTGC 1 -- ds50016Minor allele frequency- T:0.00NS EA NA 414
    rs785594101,2
    		C--59009653(+) CACTAA/GCCCCT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SLC27A5 (59009700 - 59023432 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for SLC27A5
         3 CNVs: 50240 50238 50239
    Human Gene Mutation Database (HGMD): SLC27A5

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    Disorders / Diseases
    for SLC27A5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC27A5 for disorders           About GeneDecksing

    OMIM gene information: 603314    OMIM disorders: --

    6 diseases for SLC27A5:    About MalaCards
    fatty liver disease    liver disease    cholesterol    tuberculosis
    hepatitis    mycobacterium tuberculosis

    1 disease from the University of Copenhagen DISEASES database for SLC27A5:
    Fatty liver disease
    Human Genome Epidemiology (HuGE) Navigator: SLC27A5 (2 documents)

    Export disorders for SLC27A5 gene to outside databases

    Publications
    for SLC27A5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC27A5 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with SLC27A5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase. (PubMed id 10749848)1, 2, 3 Steinberg S.J.... Watkins P.A. (2000)
    2. Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein. (PubMed id 10479480)1, 2, 3 Steinberg S.J.... Watkins P.A. (1999)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling. (PubMed id 11980911)1, 2 Mihalik S.J....Watkins P.A. (2002)
    5. A novel relative of the very-long-chain acyl-CoA synthetase and fatty acid transporter protein genes with a distinct expression pattern. (PubMed id 9642112)1, 9 Berger J....Forss-Petter S. (1998)
    6. Bile acid-CoA ligase deficiency--a new inborn error of bile acid metabolism. (PubMed id 22089923)1 Chong C.P....Clayton P.T. (2012)
    7. A promoter polymorphism in the liver-specific fatty a cid transport protein 5 is associated with features of the metabolic syndrome a nd steatosis. (PubMed id 20945272)1 Auinger A....Rubin D. (2010)
    8. Candidate gene association study of type 2 diabetes in a nested case-control study of the EPIC-Potsdam cohort - role of fat assimilation. (PubMed id 17266179)1 Fisher E....Doring F. (2007)
    9. Heat shock transcription factor (Hsf)-4b recruits Brg1 during the G1 phase of the cell cycle and regulates the expression of heat shock proteins. (PubMed id 16552721)1 Tu N....Mivechi N.F. (2006)
    10. Human very long-chain acyl-CoA synthetase and two human homologs: initial characterization and relationship to fatty acid transport protein. (PubMed id 10471116)1 Watkins P.A....Steinberg S.J. (1999)

    External Searches for SLC27A5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    Genome Databases showing SLC27A5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10998 HGNC: 10999 AceView: SLC27A5 Ensembl:ENSG00000083807 euGenes: HUgn10998
    ECgene: SLC27A5 Kegg: 10998 H-InvDB: SLC27A5

    Other Databases showing SLC27A5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC27A5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC27A5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC27A5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC27A5 gene:
    Search GeneIP for patents involving SLC27A5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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