Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC27A4 Gene

protein-coding   GIFtS: 62
GCID: GC09P131102

Solute Carrier Family 27 (Fatty Acid Transporter), Member...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 27 (Fatty Acid Transporter), Member 41 2     FATP-43
FATP42 3 5     Fatty Acid Transport Protein 43
ACSVL42 3     Solute Carrier Family 27 Member 43
IPS2 5     EC 6.2.18
Long-Chain Fatty Acid Transport Protein 42     EC 6.2.1.78
EC 6.2.1.-3     

External Ids:    HGNC: 109981   Entrez Gene: 109992   Ensembl: ENSG000001671147   OMIM: 6041945   UniProtKB: Q6P1M03   

Export aliases for SLC27A4 gene to outside databases

Previous GC identifers: GC09P122217 GC09P122749 GC09P124556 GC09P126478 GC09P128182 GC09P130142 GC09P100716


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC27A4 Gene:
This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of
long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of
mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes.
Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this
gene have been associated with ichthyosis prematurity syndrome. (provided by RefSeq, Apr 2010)

GeneCards Summary for SLC27A4 Gene: 
SLC27A4 (solute carrier family 27 (fatty acid transporter), member 4) is a protein-coding gene. Diseases associated with SLC27A4 include ichthyosis prematurity syndrome, and cutaneous mastocytosis, and among its related super-pathways are Transmembrane transport of small molecules and Transport of organic anions. GO annotations related to this gene include very long-chain fatty acid-CoA ligase activity and nucleotide binding. An important paralog of this gene is SLC27A5.

UniProtKB/Swiss-Prot: S27A4_HUMAN, Q6P1M0
Function: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the
principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal
barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and
very-long-chain fatty acids (By similarity)

Gene Wiki entry for SLC27A4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC27A4 gene promoter:
         STAT1   AML1a   GCNF   p300   Olf-1   STAT1beta   STAT1alpha   C/EBPalpha   GCNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC27A4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC27A4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC27A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.13

SLC27A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC27A4 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P131102:  view genomic region     (about GC identifiers)

Start:
131,102,839 bp from pter      End:
131,123,749 bp from pter
Size:
20,911 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S27A4_HUMAN, Q6P1M0 (See protein sequence)
Recommended Name: Long-chain fatty acid transport protein 4  
Size: 643 amino acids; 72064 Da
Subcellular location: Membrane; Multi-pass membrane protein (Probable)
Miscellaneous: SLC27A4/FATP4-mediated fatty acid uptake is associated to paramaters related to insulin resistance,
which is associated with disturbed fatty acid metabolism and homeostasis, such as obesity. SLC27A4/FATP4
expression is positively correlated with acquired obesity
Sequence caution: Sequence=AAD11623.1; Type=Frameshift; Positions=362, 387, 612, 619;
Secondary accessions: A8K2F7 O95186

Explore the universe of human proteins at neXtProt for SLC27A4: NX_Q6P1M0

Explore proteomics data for SLC27A4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6P1M0

  • 4/21 DME Specific Peptides for SLC27A4 (Q6P1M0) (see all 21)
     GRYVPLD  RWKGENV  CIPCQPG  VHSRYYR 

    SLC27A4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC27A4 Protein Expression
    REFSEQ proteins: NP_005085.2  
    ENSEMBL proteins: 
     ENSP00000361961   ENSP00000300456  
    Reactome Protein details: Q6P1M0
    Human Recombinant Protein Products for SLC27A4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SLC27A4
    GenScript Custom Purified and Recombinant Proteins Services for SLC27A4
    Novus Biologicals SLC27A4 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane IDA--
    GO:0005886plasma membrane TAS--
    GO:0005902microvillus IEA--
    GO:0016021integral to membrane IEA--

    SLC27A4 for ontologies           About GeneDecksing



    SLC27A4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SLC27A4 (FATP4)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLC27A4
    GenScript Custom Superior Antibodies Services for SLC27A4
    Abcam antibodies for SLC27A4
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for SLC27A4
    Search LSBio for Antibodies for SLC27A4 

    Assay Products for SLC27A4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC27A4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC27A4
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers
    ACS: Acyl-CoA synthetase family

    IUPHAR Guide to PHARMACOLOGY protein family classification: Fatty acid transport protein 4 
    SLC27 family of fatty acid transporters

    3 InterPro protein domains:
     IPR022272 Lipocalin_CS
     IPR000873 AMP-dep_Synth/Lig
     IPR020845 AMP-binding_CS

    Graphical View of Domain Structure for InterPro Entry Q6P1M0

    ProtoNet protein and cluster: Q6P1M0

    1 Blocks protein domain: IPB000873 AMP-binding signature

    UniProtKB/Swiss-Prot: S27A4_HUMAN, Q6P1M0
    Similarity: Belongs to the ATP-dependent AMP-binding enzyme family


    SLC27A4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S27A4_HUMAN, Q6P1M0
    Function: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the
    principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal
    barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and
    very-long-chain fatty acids (By similarity)

         Enzyme Numbers (IUBMB): EC 6.2.12 EC 6.2.1.72 EC 6.2.1.-1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003824catalytic activity ----
    GO:0004467long-chain fatty acid-CoA ligase activity IDA--
    GO:0015245fatty acid transporter activity TAS9878842
    GO:0031957very long-chain fatty acid-CoA ligase activity IEA--
         
    SLC27A4 for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Slc27a4):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  growth/size 
     homeostasis/metabolism  integument  mortality/aging  no phenotypic analysis  respiratory system 
     skeleton 

    SLC27A4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SLC27A4: Slc27a4tm1.1Wsr Slc27a4tm1Afst

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC27A4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC27A4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC27A4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC27A4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC27A4
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC27A4 (see all 30):
    hsa-miR-328 hsa-miR-125a-5p hsa-miR-4328 hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-449a hsa-miR-9 hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidSLC27A4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC27A4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC27A4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC27A4
    Sirion Biotech Customized adenovirus for overexpression of SLC27A4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SLC27A4 (see all 7)
    OriGene ORF clones in mouse, rat for SLC27A4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC27A4 (NM_005094)
    Sino Biological Human cDNA Clone for SLC27A4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC27A4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC27A4
    Sirion Biotech Customized lentivirus for stable overexpression of SLC27A4 
                         Customized lentivirus expression plasmids for stable overexpression of SLC27A4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC27A4
    Search LifeMap BioReagents cell lines for SLC27A4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC27A4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC27A4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transmembrane transport of small molecules0.50
    2Transport of organic anions
    Transport of vitamins, nucleosides, and related molecules0.34
    3Transport of fatty acids
    Transport of fatty acids
    4PPAR signaling pathway
    PPAR signaling pathway
    5Fat digestion and absorption
    Fat digestion and absorption

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4        Reactome Pathways for SLC27A4
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of vitamins, nucleosides, and related molecules
    Transport of fatty acids


    2         Kegg Pathways  (Kegg details for SLC27A4):
        PPAR signaling pathway
    Fat digestion and absorption


    SLC27A4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC27A4

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SLC27A4 (Q6P1M03 ENSP000003004564) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BECN1Q144573, ENSP000003552314I2D: score=3 STRING: ENSP00000355231
    TMBIM4Q9HC243, ENSP000003509654I2D: score=2 STRING: ENSP00000350965
    UBCENSP000003448184STRING: ENSP00000344818
    EPS8ENSP000002811724STRING: ENSP00000281172
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000038very long-chain fatty acid metabolic process ----
    GO:0001579medium-chain fatty acid transport IEA--
    GO:0001676long-chain fatty acid metabolic process IDA--
    GO:0006629lipid metabolic process TAS9878842
    GO:0006631fatty acid metabolic process ----

    SLC27A4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC27A4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC27A4 (S27A4)

    10/40 HMDB Compounds for SLC27A4 (see all 40)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--

    2 Novoseek inferred chemical compound relationships for SLC27A4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty acid 69.7 27 19631310 (2), 11404000 (2), 15827101 (2), 12697906 (2) (see all 12)
    lipid 32.1 2 19188502 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC27A4 / S27A4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC27A4 gene: 
    NM_005094.3  

    Unigene Cluster for SLC27A4:

    Solute carrier family 27 (fatty acid transporter), member 4
    Hs.656699  [show with all ESTs]
    Unigene Representative Sequence: NM_005094
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372870(uc004buu.3) ENST00000300456(uc004but.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC27A4
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC27A4 (see all 30):
    hsa-miR-328 hsa-miR-125a-5p hsa-miR-4328 hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-449a hsa-miR-9 hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidSLC27A4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC27A4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC27A4
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC27A4 (see all 7)
    OriGene ORF clones in mouse, rat for SLC27A4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC27A4 (NM_005094)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC27A4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC27A4
    Sirion Biotech Customized lentivirus for stable overexpression of SLC27A4 
                         Customized lentivirus expression plasmids for stable overexpression of SLC27A4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLC27A4
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC27A4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC27A4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC27A4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC27A4

    Additional mRNA sequence: 

    AF055899.1 AK000722.1 AK027504.1 AK074831.1 AK290222.1 BC004268.1 BC009959.2 BC065003.1 

    7 DOTS entries:

    DT.455993  DT.91925762  DT.100747358  DT.102840311  DT.92428311  DT.102834175  DT.121185429 

    24/126 AceView cDNA sequences (see all 126):

    BM701112 BM982407 BG740922 BM838531 BI260635 AL556374 AA350218 BC065003 
    BX114133 AI693456 BG740964 BQ052503 BF934496 AI659988 BM554654 BF971337 
    AA364092 BU162733 BQ068324 CB150971 BC009959 BM795520 BF510163 CA454443 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC27A4 expression in normal human tissues (normalized intensities)      SLC27A4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCAAGTTCC
    SLC27A4 Expression
    About this image


    SLC27A4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Midbrain tegmentum
             brain/midbrain   
     
     Eye (Sensory Organs)
             Retina
     
     Uterus (Reproductive System)
             CERVIX   
     
     Lower Urinary Tract (Urinary System)
             visceral organ   
     
     Spinal Cord (Nervous System)

    See SLC27A4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC27A4

    SOURCE GeneReport for Unigene cluster: Hs.656699

    UniProtKB/Swiss-Prot: S27A4_HUMAN, Q6P1M0
    Tissue specificity: Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in
    heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow,
    skeletal muscle and aorta. Expressed in adipose tissue

        SABiosciences Expression via Pathway-Focused PCR Arrays including SLC27A4: 
              Insulin Signaling Pathway in human mouse rat
              Fatty Acid Metabolism in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              PPAR Targets in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLC27A4
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC27A4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC27A4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC27A4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC27A4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC27A4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC27A4 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc27a41 , 5 solute carrier family 27 (fatty acid transporter), more1, 5 87.61(n)1
    92.22(a)1
      2 (20.64 cM)5
    265691  NM_011989.41  NP_036119.11 
     298026345 
    chicken
    (Gallus gallus)
    Aves SLC27A41 solute carrier family 27 (fatty acid transporter), more 70.09(n)
    67.65(a)
      417220  XM_415504.3  XP_415504.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLC27A46
    Uncharacterized protein
    78(a)
    1 ↔ 1
    GL344072.1(69448-78985)
    zebrafish
    (Danio rerio)
    Actinopterygii slc27a41 solute carrier family 27 (fatty acid transporter), more 67.91(n)
    69.98(a)
      550432  NM_001017737.1  NP_001017737.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fatp1 , 3 long-chain fatty acid transporter3
    Fatty acid (long chain) transport protein1
    45(a)
    (best of 3)3
    55.79(n)1
    48.36(a)1
      442271  NM_001169469.11  NP_001162940.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F28D1.93
    acs-201
    fatty acid transport protein3
    Protein ACS-201
    40(a)
    (best of 2)3
    47.93(n)1
    42.99(a)1
      IV(12392652-12396936)3
    1781901  NM_069966.51  NP_502367.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FAT16
    Very long chain fatty acyl-CoA synthetase and long...
    28(a)
    1 → many
    II(318266-320275)


    ENSEMBL Gene Tree for SLC27A4 (if available)
    TreeFam Gene Tree for SLC27A4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC27A4 gene
    SLC27A52  SLC27A22  SLC27A12  SLC27A32  SLC27A62  
    6 SIMAP similar genes for SLC27A4 using alignment to 2 protein entries:     S27A4_HUMAN (see all proteins):
    FLJ00336    SLC27A1    SLC27A2    SLC27A6    SLC27A5    SLC27A3

    SLC27A4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/632 SNPs in SLC27A4 are shown (see all 632)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0631924
    Ichthyosis prematurity syndrome (IPS)4--see VAR_0631922 A T mis40--------
    VAR_0631944
    Ichthyosis prematurity syndrome (IPS)4--see VAR_0631942 Q R mis40--------
    VAR_0645004
    Ichthyosis prematurity syndrome (IPS)4--see VAR_0645002 R C mis40--------
    VAR_0631934
    Ichthyosis prematurity syndrome (IPS)4--see VAR_0631932 S P mis40--------
    VAR_0631954
    Ichthyosis prematurity syndrome (IPS)4--see VAR_0631952 R H mis40--------
    rs1378531311,2
    Cpathogenic1131120419(+) CACTGC/ACTCAC 2 /* /C stg11Minor allele frequency- A:0.00NA 4382
    rs1378531341,2
    Cpathogenic1131127581(+) CGGCCA/GGTGCC 2 Q R mis10--------
    rs780700341,2
    C--131100883(+) CTCGG-/A/AA  
            
    AAAAA
    1 -- us2k10--------
    rs1836332151,2
    --131113429(+) AGCCTA/GGGCGA 1 -- us2k10--------
    rs1881665261,2
    --131113453(+) CGTCTC/TGGAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC27A4 (131102839 - 131123749 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SLC27A4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2660941CNV Deletion23128226
    esv2739070CNV Deletion23290073
    nsv415888CNV Insertion16902084
    nsv831728CNV Loss17160897
    dgv8294n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): SLC27A4
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC27A4
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC27A4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604194   
    OMIM disorders: 608649  
    UniProtKB/Swiss-Prot: S27A4_HUMAN, Q6P1M0
  • Ichthyosis prematurity syndrome (IPS) [MIM:608649]: A keratinization disorder characterized by
    complications in the second trimester of pregnancy resulting from polyhydramnion, with premature birth of a child
    with thick caseous desquamating epidermis, respiratory complications and transient eosinophilia. After recovery
    during the first months of life, the symptoms are relatively benign and the patients suffer from a lifelong
    non-scaly ichthyosis with atopic manifestations. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 13 diseases for SLC27A4:    About MalaCards
    ichthyosis prematurity syndrome    cutaneous mastocytosis    diffuse cutaneous mastocytosis    mastocytosis
    ichthyosis    insulin resistance    eosinophilia    hyperparathyroidism
    obesity    tuberculosis    endotheliitis    prostate cancer
    prostatitis


    SLC27A4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC27A4
    Human Genome Epidemiology (HuGE) Navigator: SLC27A4 (4 documents)

    Export disorders for SLC27A4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC27A4 gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with SLC27A4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic and structural evaluation of fatty acid transport protein-4 in relation to markers of the insulin resistance syndrome. (PubMed id 14715877)1, 2, 4, 9 Gertow K.... Fisher R.M. (2004)
    2. Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4). (PubMed id 9878842)1, 2, 3 Fitscher B.A.... Stremmel W. (1998)
    3. Mutations in the fatty acid transport protein 4 gene cause the ichthyosis prematurity syndrome. (PubMed id 19631310)1, 2, 9 Klar J....Fischer J. (2009)
    4. Identification of type 2 diabetes-associated combinat ion of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (2010)
    5. L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (2010)
    6. A novel mutation in the fatty acid transport protein 4 gene in a patient initially described as affected by self-healing congenital verruciform hyperkeratosis. (PubMed id 20815031)1, 2 Morice-Picard F....Fischer J. (2010)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Requirement of fatty acid transport protein 4 for deve lopment, maturation, and function of sebaceous glands in a mouse model of ichthy osis prematurity syndrome. (PubMed id 23271751)1 Lin M.H....Miner J.H. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10999 HGNC: 10998 AceView: SLC27A4 Ensembl:ENSG00000167114 euGenes: HUgn10999
    ECgene: SLC27A4 Kegg: 10999 H-InvDB: SLC27A4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC27A4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC27A4 gene:
    Search GeneIP for patents involving SLC27A4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for SLC27A4 (FATP4)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     cDNA Clones for SLC27A4 (FATP4)   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SLC27A4  
     OriGene qPCR primer pairs and template standards for SLC27A4   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC27A4  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC27A4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC27A4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC27A4   OriGene Custom Protein Services for SLC27A4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC27A4
     QIAGEN SeqTarget long-range PCR primers for resequencing SLC27A4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC27A4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC27A4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC27A4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC27A4
     GenScript Custom Purified and Recombinant Proteins Services for SLC27A4 GenScript cDNA clones with any tag delivered in your preferred vector for SLC27A4
     GenScript Custom Assay Services for SLC27A4 GenScript Custom Superior Antibodies Services for SLC27A4
     GenScript Custom overexpressing Cell Line Services for SLC27A4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SLC27A4 promoter
     Search Chromatin IP Primers for SLC27A4
     RT2 qPCR Primer Assay in human, mouse, rat SLC27A4
     GNC Network for SLC27A4
     SABiosciences PCR Arrays including human, mouse, rat SLC27A4
     Search Tocris compounds for SLC27A4 (S27A4)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for SLC27A4
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SLC27A4 proteins
     Antibodies for SLC27A4
     See all of Abcam's Antibodies, Kits and Proteins for SLC27A4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for SLC27A4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC27A4
     SwitchGear 3'UTR luciferase reporter plasmids for SLC27A4
     SwitchGear Promoter luciferase reporter plasmids for SLC27A4
     ThermoFisher Antibodies for SLC27A4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC27A4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC27A4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC27A4
    Customized:
     lentivirus for stable overexpression of SLC27A4
     lentivirus expression plasmids for stable overexpression of SLC27A4
     adenovirus for overexpression of SLC27A4
     Search LSBio for Antibodies for SLC27A4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC27A4 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4