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Aliases for SLC27A4 Gene

Aliases for SLC27A4 Gene

  • Solute Carrier Family 27 (Fatty Acid Transporter), Member 4 2 3
  • FATP4 3 4 6
  • ACSVL4 3 4
  • IPS 3 6
  • Long-Chain Fatty Acid Transport Protein 4 3
  • Solute Carrier Family 27 Member 4 4
  • Fatty Acid Transport Protein 4 4
  • EC 6.2.1.7 63
  • EC 6.2.1.- 4
  • EC 6.2.1 63
  • FATP-4 4

External Ids for SLC27A4 Gene

Previous GeneCards Identifiers for SLC27A4 Gene

  • GC09P122217
  • GC09P122749
  • GC09P124556
  • GC09P126478
  • GC09P128182
  • GC09P130142
  • GC09P131102
  • GC09P100716

Summaries for SLC27A4 Gene

Entrez Gene Summary for SLC27A4 Gene

  • This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. [provided by RefSeq, Apr 2010]

GeneCards Summary for SLC27A4 Gene

SLC27A4 (Solute Carrier Family 27 (Fatty Acid Transporter), Member 4) is a Protein Coding gene. Diseases associated with SLC27A4 include ichthyosis prematurity syndrome and diffuse cutaneous mastocytosis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Fat digestion and absorption. GO annotations related to this gene include nucleotide binding and very long-chain fatty acid-CoA ligase activity. An important paralog of this gene is SLC27A1.

UniProtKB/Swiss-Prot for SLC27A4 Gene

  • Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity).

Gene Wiki entry for SLC27A4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC27A4 Gene

Genomics for SLC27A4 Gene

Regulatory Elements for SLC27A4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC27A4 Gene

Start:
128,340,560 bp from pter
End:
128,361,470 bp from pter
Size:
20,911 bases
Orientation:
Plus strand

Genomic View for SLC27A4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC27A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC27A4 Gene

Proteins for SLC27A4 Gene

  • Protein details for SLC27A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1M0-S27A4_HUMAN
    Recommended name:
    Long-chain fatty acid transport protein 4
    Protein Accession:
    Q6P1M0
    Secondary Accessions:
    • A8K2F7
    • O95186
    • Q96G53

    Protein attributes for SLC27A4 Gene

    Size:
    643 amino acids
    Molecular mass:
    72064 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • SLC27A4/FATP4-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which is associated with disturbed fatty acid metabolism and homeostasis, such as obesity. SLC27A4/FATP4 expression is positively correlated with acquired obesity
    SequenceCaution:
    • Sequence=AAD11623.1; Type=Frameshift; Positions=362, 387, 612, 619; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC27A4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC27A4 Gene

Proteomics data for SLC27A4 Gene at MOPED

Post-translational modifications for SLC27A4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC27A4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for SLC27A4 Gene

Gene Families for SLC27A4 Gene

HGNC:
  • ACS :Acyl-CoA synthetase family
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC27A4 Gene

Suggested Antigen Peptide Sequences for SLC27A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P1M0

UniProtKB/Swiss-Prot:

S27A4_HUMAN :
  • Q6P1M0
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with SLC27A4: view

Function for SLC27A4 Gene

Molecular function for SLC27A4 Gene

UniProtKB/Swiss-Prot Function: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity).

Enzyme Numbers (IUBMB) for SLC27A4 Gene

Gene Ontology (GO) - Molecular Function for SLC27A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003824 catalytic activity --
GO:0004467 long-chain fatty acid-CoA ligase activity IDA 22022213
GO:0015245 fatty acid transporter activity TAS 9878842
GO:0031957 very long-chain fatty acid-CoA ligase activity IEA --
genes like me logo Genes that share ontologies with SLC27A4: view
genes like me logo Genes that share phenotypes with SLC27A4: view

Animal Models for SLC27A4 Gene

MGI Knock Outs for SLC27A4:

Animal Model Products

CRISPR Products

miRNA for SLC27A4 Gene

miRTarBase miRNAs that target SLC27A4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC27A4

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for SLC27A4 Gene

Localization for SLC27A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC27A4 Gene

Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC27A4 Gene COMPARTMENTS Subcellular localization image for SLC27A4 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC27A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IDA 22022213
GO:0005886 plasma membrane TAS --
GO:0005902 microvillus IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with SLC27A4: view

Pathways for SLC27A4 Gene

genes like me logo Genes that share pathways with SLC27A4: view

PCR Array Products

Gene Ontology (GO) - Biological Process for SLC27A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000038 very long-chain fatty acid metabolic process --
GO:0001579 medium-chain fatty acid transport IEA --
GO:0001676 long-chain fatty acid metabolic process IDA 22022213
GO:0006629 lipid metabolic process TAS 9878842
GO:0006631 fatty acid metabolic process --
genes like me logo Genes that share ontologies with SLC27A4: view

Compounds for SLC27A4 Gene

(40) HMDB Compounds for SLC27A4 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(2) Novoseek inferred chemical compound relationships for SLC27A4 Gene

Compound -log(P) Hits PubMed IDs
fatty acid 69.7 16
lipid 32.1 1
genes like me logo Genes that share compounds with SLC27A4: view

Transcripts for SLC27A4 Gene

mRNA/cDNA for SLC27A4 Gene

Unigene Clusters for SLC27A4 Gene

Solute carrier family 27 (fatty acid transporter), member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC27A4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC27A4 Gene

No ASD Table

Relevant External Links for SLC27A4 Gene

GeneLoc Exon Structure for
SLC27A4
ECgene alternative splicing isoforms for
SLC27A4

Expression for SLC27A4 Gene

mRNA expression in normal human tissues for SLC27A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC27A4 Gene

SOURCE GeneReport for Unigene cluster for SLC27A4 Gene Hs.656699

mRNA Expression by UniProt/SwissProt for SLC27A4 Gene

Q6P1M0-S27A4_HUMAN
Tissue specificity: Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tissue.
genes like me logo Genes that share expressions with SLC27A4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SLC27A4 Gene

Orthologs for SLC27A4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC27A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC27A4 35
  • 99.53 (n)
  • 99.69 (a)
SLC27A4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC27A4 35
  • 87.92 (n)
  • 88.8 (a)
SLC27A4 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC27A4 35
  • 88.7 (n)
  • 91.6 (a)
SLC27A4 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc27a4 35
  • 87.61 (n)
  • 92.22 (a)
Slc27a4 16
Slc27a4 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC27A4 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc27a4 35
  • 87.61 (n)
  • 90.98 (a)
chicken
(Gallus gallus)
Aves SLC27A4 35
  • 70.09 (n)
  • 67.65 (a)
SLC27A4 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC27A4 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc27a4 35
  • 69.1 (n)
  • 72.01 (a)
zebrafish
(Danio rerio)
Actinopterygii slc27a4 35
  • 67.91 (n)
  • 69.98 (a)
slc27a4 36
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001763 35
  • 56.77 (n)
  • 48.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30194 36
  • 40 (a)
ManyToMany
CG3394 36
  • 38 (a)
ManyToMany
Fatp 35
  • 55.79 (n)
  • 48.36 (a)
Fatp 36
  • 42 (a)
ManyToMany
CG3394 37
  • 41 (a)
CG30194 37
  • 42 (a)
Fatp 37
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea acs-20 35
  • 48.48 (n)
  • 43.82 (a)
acs-20 36
  • 39 (a)
ManyToMany
acs-22 36
  • 39 (a)
ManyToMany
D1009.1a 37
  • 39 (a)
F28D1.9 37
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAT1 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9398 36
  • 43 (a)
OneToMany
Species with no ortholog for SLC27A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC27A4 Gene

ENSEMBL:
Gene Tree for SLC27A4 (if available)
TreeFam:
Gene Tree for SLC27A4 (if available)

Paralogs for SLC27A4 Gene

Paralogs for SLC27A4 Gene

Selected SIMAP similar genes for SLC27A4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC27A4: view

Variants for SLC27A4 Gene

Sequence variations from dbSNP and Humsavar for SLC27A4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1058685 -- 128,342,725(+) AATGC(A/C)Caatt intron-variant
rs2003560 -- 128,355,943(-) AGCCC(C/T)GTCTG intron-variant
rs2240952 -- 128,355,480(-) GACAC(A/G)TTCTC reference, synonymous-codon
rs2240953 - 128,348,613(-) CGCAC(C/T)GGGCT missense, reference
rs2416979 -- 128,342,277(-) TTTCG(A/G)CTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC27A4 Gene

Variant ID Type Subtype PubMed ID
dgv8294n71 CNV Loss 21882294
nsv831728 CNV Loss 17160897
nsv415888 CNV Insertion 16902084
esv2739070 CNV Deletion 23290073
esv2660941 CNV Deletion 23128226

Relevant External Links for SLC27A4 Gene

HapMap Linkage Disequilibrium report
SLC27A4
Human Gene Mutation Database (HGMD)
SLC27A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC27A4 Gene

Disorders for SLC27A4 Gene

(1) OMIM Diseases for SLC27A4 Gene (604194)

UniProtKB/Swiss-Prot

S27A4_HUMAN
  • Ichthyosis prematurity syndrome (IPS) [MIM:608649]: A keratinization disorder characterized by complications in the second trimester of pregnancy resulting from polyhydramnion, with premature birth of a child with thick caseous desquamating epidermis, respiratory complications and transient eosinophilia. After recovery during the first months of life, the symptoms are relatively benign and the patients suffer from a lifelong non-scaly ichthyosis with atopic manifestations. {ECO:0000269 PubMed:19631310, ECO:0000269 PubMed:20815031}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SLC27A4

Genetic Association Database (GAD)
SLC27A4
Human Genome Epidemiology (HuGE) Navigator
SLC27A4
genes like me logo Genes that share disorders with SLC27A4: view

Publications for SLC27A4 Gene

  1. Genetic and structural evaluation of fatty acid transport protein-4 in relation to markers of the insulin resistance syndrome. (PMID: 14715877) Gertow K. … Fisher R.M. (J. Clin. Endocrinol. Metab. 2004) 3 4 23 48
  2. Mutations in the fatty acid transport protein 4 gene cause the ichthyosis prematurity syndrome. (PMID: 19631310) Klar J. … Fischer J. (Am. J. Hum. Genet. 2009) 3 4 23
  3. Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4). (PMID: 9878842) Fitscher B.A. … Stremmel W. (Biochim. Biophys. Acta 1998) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4

Products for SLC27A4 Gene

Sources for SLC27A4 Gene

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