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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC27A2 Gene

protein-coding   GIFtS: 62
GCID: GC15P050474

solute carrier family 27 (fatty acid transporter), member...


(Previous symbol: FACVL1)
 Explore 13 diseases affiliated with
SLC27A2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC27A2    

Aliases
for SLC27A2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 27 (Fatty Acid Transporter), Member 21 2     Solute Carrier Family 27 Member 22 3
FACVL11 2 3 5     Very Long-Chain-Fatty-Acid-CoA Ligase2 3
VLACS1 2 3 5     FATP-22 3
ACSVL11 2 3     THCA-CoA Ligase2 3
FATP21 2 3     Very Long-Chain Acyl-CoA Synthetase2
VLCS1 2 3     Very Long-Chain Fatty-Acid-Coenzyme A Ligase 12
HsT172261 2     Very-Long-Chain Acyl-CoA Synthetase2
HFACVL11     EC 6.2.1.-3
Fatty Acid Transport Protein 22 3     EC 6.2.1.33
Fatty-Acid-Coenzyme A Ligase, Very Long-Chain 12 3     EC 6.2.18
Long-Chain-Fatty-Acid--CoA Ligase2 3     EC 6.2.1.78

External Ids:    HGNC: 109961   Entrez Gene: 110012   Ensembl: ENSG000001402847   OMIM: 6032475   UniProtKB: O149753   

Export aliases for SLC27A2 gene to outside databases

Previous GC identifers: GC15U990072 GC15P043520 GC15P048053 GC15P048190 GC15P048261 GC15P027305


Summaries
for SLC27A2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC27A2:
The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in
substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free
long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid
degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more
carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic
reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible
for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Apr 2009)

UniProtKB/Swiss-Prot: S27A2_HUMAN, O14975
Function: Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile
acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro,
activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving
from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates
long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in
translocation of long-chain fatty acids (LFCA) across membranes (By similarity)

Gene Wiki entry for SLC27A2


Genomic Views
for SLC27A2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC27A2 gene promoter:
         Sp1   Pax-5   STAT5A   CUTL1   AP-4   C/EBPalpha   HEN1   CHOP-10   SEF-1 (1)   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC27A2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC27A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC27A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q21.2

SLC27A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC27A2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P050474:  view genomic region     (about GC identifiers)

Start:
 50,474,393 bp from pter      End:
 50,528,592 bp from pter
Size:
 54,200 bases      Orientation:
 plus strand

Proteins
for SLC27A2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: S27A2_HUMAN, O14975 (See protein sequence)
Recommended Name: Very long-chain acyl-CoA synthetase  
Size: 620 amino acids; 70312 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass
membrane protein. Note=Peripheral membrane associated with the lumenal side of peroxisomes
Secondary accessions: A8K2J7 Q53FY6 Q6PF09
Alternative splicing: 2 isoforms:  O14975-1   O14975-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC27A2: NX_O14975

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14975

    • 2 DME Specific Peptides for SLC27A2 (O14975)
     RWKGENV  TSGTTGLPKA 

    SLC27A2 Protein expression data from MOPED and PaxDb:    About this image 
    SLC27A2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001153101.1  NP_003636.2  

    ENSEMBL proteins: 
     ENSP00000267842   ENSP00000370289   ENSP00000444549  
    Reactome Protein details: O14975
    Human Recombinant Protein Products for SLC27A2: 
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    Novus Biologicals SLC27A2 Proteins
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    Uscn Proteins for SLC27A2

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005777peroxisome ----
    GO:0005778peroxisomal membrane TAS--
    GO:0005779integral to peroxisomal membrane IDA10198260
    GO:0005783endoplasmic reticulum ----

    SLC27A2 for ontologies           About GeneDecksing



    SLC27A2 Antibody Products: 
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    Uscn ELISAs and CLIAs for SLC27A2

    Protein Domains /
    Families
    for SLC27A2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC27A2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000873 AMP-dep_Synth/Lig
     IPR020845 AMP-binding_CS

    Graphical View of Domain Structure for InterPro Entry O14975

    ProtoNet protein and cluster: O14975

    1 Blocks protein family: IPB000873 AMP-binding signature

    UniProtKB/Swiss-Prot: S27A2_HUMAN, O14975
    Similarity: Belongs to the ATP-dependent AMP-binding enzyme family


    Function
    for SLC27A2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S27A2_HUMAN, O14975
    Function: Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile
    acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro,
    activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving
    from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates
    long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in
    translocation of long-chain fatty acids (LFCA) across membranes (By similarity)
    Catalytic activity: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA
    Catalytic activity: ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA

         Enzyme Numbers (IUBMB): EC 6.2.12 EC 6.2.1.72 EC 6.2.1.31 EC 6.2.1.-1

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004467long-chain fatty acid-CoA ligase activity IDA--
    GO:0005102receptor binding IPI--
    GO:0005524ATP binding IEA--
    GO:0015245fatty acid transporter activity IEA--
    GO:0019899enzyme binding IPI16781659
         
    SLC27A2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slc27a2):
     cellular  normal 

    SLC27A2 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Slc27a2tm1Kds for SLC27A2
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC27A2 

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC27A2 (see all 4)
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    Pathways & Interactions
    for SLC27A2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1fatty acid alpha-oxidation II
    		fatty acid alpha-oxidation II1.00
    		fatty acid beta-oxidation I0.39
    		fatty acid activation0.67
    		Alpha-oxidation of phytanate0.30
    		stearate biosynthesis I (animals)0.43
    2Synthesis of bile acids and bile salts
    		Synthesis of bile acids and bile salts1.00
    		Synthesis of bile acids and bile salts via 24-hydroxycholesterol0.53
    		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol0.79
    		bile acid biosynthesis, neutral pathway0.52
    		Bile acid and bile salt metabolism0.70
    3Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    4Peroxisomal lipid metabolism
    		Peroxisomal lipid metabolism1.00
    5Peroxisome
    		Peroxisome1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6 BioSystems Pathways for SLC27A2 (see all 6) 
        stearate biosynthesis I (animals)
    bile acid biosynthesis, neutral pathway
    fatty acid alpha-oxidation II
    fatty acid beta-oxidation I
    gamma-linolenate biosynthesis II (animals)

    5/8        Reactome Pathways for SLC27A2 (see all 8)
        Alpha-oxidation of phytanate
    Synthesis of bile acids and bile salts via 24-hydroxycholesterol
    Bile acid and bile salt metabolism
    Metabolism
    Peroxisomal lipid metabolism

    1 PharmGKB Pathway for SLC27A2
        Metformin Pathway, Pharmacokinetics

    2         Kegg Pathways  (Kegg details for SLC27A2):
        PPAR signaling pathway
    Peroxisome


    SLC27A2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC27A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/62 Interacting proteins for SLC27A2 (O149752, 3 ENSP000002678424) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3MINT-3319021 I2D: score=1 
    GAPDHP044063, ENSP000002292394I2D: score=1 STRING: ENSP00000229239
    SQLEQ145343, ENSP000002658964I2D: score=1 STRING: ENSP00000265896
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    YWHAQP273483, ENSP000002380814I2D: score=1 STRING: ENSP00000238081
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000038very long-chain fatty acid metabolic process ----
    GO:0001561fatty acid alpha-oxidation TAS--
    GO:0001676long-chain fatty acid metabolic process IDA--
    GO:0006635fatty acid beta-oxidation IDA10198260
    GO:0006699bile acid biosynthetic process TAS--

    SLC27A2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC27A2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC27A2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC27A2

    10/34 HMDB Compounds for SLC27A2 (see all 34)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    20-COOH-leukotriene E420-COOH-LTE4 (see all 3)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    6,9,12,15,18,21-Tetracosahexaenoic acidall-cis-6,9,12,15,18,21-tetracosahexaenoate (see all 8)----
    5 Novoseek chemical compound relationships for SLC27A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lignoceric acid 84.8 1 8978480 (1)
    acyl-coa 81.4 15 7818538 (2), 11330068 (2), 9660783 (2), 10227685 (1) (see all 11)
    phytanic acid 72.4 1 8978480 (1)
    fatty acid 61.8 10 9660783 (3), 20054868 (1), 9642112 (1), 12454267 (1) (see all 6)
    atp 12 1 12048192 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC27A2 / S27A2 

    Transcripts
    for SLC27A2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC27A2 gene (2 alternative transcripts): 
    NM_001159629.1  NM_003645.3  

    Unigene Cluster for SLC27A2:

    Solute carrier family 27 (fatty acid transporter), member 2
    Hs.11729  [show with all ESTs]
    Unigene Representative Sequence: NM_003645
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000267842(uc001zxw.3 uc010bes.3) ENST00000380902 ENST00000544960(uc001zxx.3)
    ENST00000559938

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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF096290.1 AK123905.1 AK222859.1 AK223145.1 AK290262.1 BC057770.1 D88308.1 

    8 DOTS entries:

    DT.410735  DT.121026393  DT.101981412  DT.121026465  DT.101981413  DT.100821229  DT.97841642  DT.121026433 

    24/122 AceView cDNA sequences (see all 122):

    CA414604 NM_003645 BG698883 BQ950984 BQ323123 BF509346 BM760972 BX100106 
    BF509295 BM980042 CB161516 CR602275 CB132406 BM982730 AI912985 BM793334 
    BC057770 AF096290 BF434433 AA417177 AI636008 BE048793 BM980690 BX484117 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC27A2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
    SP1:              -           -     -                             -                                       
    SP2:              -           -     -     -                       -                                       
    SP3:                                                              -                                       
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for SLC27A2

    Expression
    for SLC27A2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC27A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCTCCATCA
    SLC27A2 Expression
    About this image

    SLC27A2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    10/12 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 12) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    KidneyLoop of HenleLoop of Henle CellsKidney
    KidneyProximal TubuleProximal Tubule CellsKidney
    AdiposeInterscapular Brown Adipose DepotAdipose
    AdiposeThoracic Perivascular AdiposeAdipose
    Head MesenchymeFrontonasal ProcessHead Mesenchyme
    KidneyEpithelial TubuleKidney
    KidneyLoop of HenleKidney
    KidneyMetanephrosKidney
    KidneyProximal TubuleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Syncytiotrophoblast-like cells (Generation of syncyt...)
    Human kidney epithelial cell spheroids (Kidney spheroids for...)

    See SLC27A2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC27A2

    SOURCE GeneReport for Unigene cluster: Hs.11729

    UniProtKB/Swiss-Prot: S27A2_HUMAN, O14975
    Tissue specificity: Expressed in liver, kidney, placenta and pancreas

        SABiosciences Expression via Pathway-Focused PCR Arrays including SLC27A2: 
              Fatty Acid Metabolism in human mouse rat
              PPAR Targets in human mouse rat

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    Orthologs
    for SLC27A2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SLC27A2 gene from 3/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLC27A21 solute carrier family 27 (fatty acid transporter), more 59.6(n)
    55.89(a)    		   426354  XM_424010.3  XP_424010.3 
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC041746.12   -- 76.68(n)    BC041746.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.190842 Transcribed sequence with moderate similarity to protein more 74.64(n)    BQ617699.1 


    ENSEMBL Gene Tree for SLC27A2 (if available)
    TreeFam Gene Tree for SLC27A2 (if available) 

    Paralogs
    for SLC27A2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC27A2 gene
    SLC27A52  SLC27A42  SLC27A12  SLC27A32  SLC27A62  
    6 SIMAP similar genes for SLC27A2 using alignment to 2 protein entries:     S27A2_HUMAN (see all proteins):
    SLC27A6    SLC27A3    SLC27A5    SLC27A4    FLJ00336    SLC27A1

    SLC27A2 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC27A2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1036 NCBI SNPs in SLC27A2 are shown (see all 1036)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1840517951,2
    		--50472561(+) AGGTGA/TCAGCA 2 -- us2k10--------
    rs802736431,2
    		F--50472567(+) CAGCAT/CTTAAA 2 -- us2k11Minor allele frequency- C:0.05EA 120
    rs287262251,2
    		C,F--50472641(+) AGCTTG/AGGTCT 2 -- us2k11Minor allele frequency- A:0.08WA 118
    rs169634001,2
    		C,F,H--50472760(+) AAAAGA/TGAAGA 2 -- us2k1 trp317Minor allele frequency- N:0.00NA EA NS WA CSA 1416
    rs1478391741,2
    		--50472881(+) GAATGA/GTTTCT 2 -- us2k10--------
    rs118547611,2
    		C,F,H--50472889(+) TCTGTC/GGGGCC 2 -- us2k117Minor allele frequency- G:0.07NA NS EA 1230
    rs71765011,2
    		C,F,A,H--50473041(+) GGATAC/G/TGAAAA 2 -- us2k127EA NA NS WA CSA 2568
    rs740149271,2
    		C,F--50473061(+) AAAACG/AGCAGG 2 -- us2k14Minor allele frequency- A:0.14WA CSA NA 242
    rs1872352171,2
    		--50473113(+) CACACA/GCCGAA 2 -- us2k10--------
    rs71768661,2
    		H--50473278(+) CCTTTC/TTTGTC 2 -- us2k1 trp34Minor allele frequency- T:0.00NS EA 418

    HapMap Linkage Disequilibrium report for SLC27A2 (50474393 - 50528592 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SLC27A2
         1 CNV: 0188

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    Disorders / Diseases
    for SLC27A2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC27A2 for disorders           About GeneDecksing

    OMIM gene information: 603247    OMIM disorders: --

    13 diseases for SLC27A2:    About MalaCards
    adrenoleukodystrophy    rhizomelic chondrodysplasia punctata    chondrodysplasia punctata    chondrodysplasia
    hepatoblastoma    alzheimer's disease    prostate cancer    cerebritis
    cholesterol    prostatitis    tuberculosis    hepatitis
    mycobacterium tuberculosis

    1 disease from the University of Copenhagen DISEASES database for SLC27A2:
    Adrenoleukodystrophy

    1 Novoseek disease relationship for SLC27A2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adrenoleukodystrophy 89.7 6 9660783 (2), 7818538 (1), 9256488 (1), 10479480 (1) (see all 5)

    Human Genome Epidemiology (HuGE) Navigator: SLC27A2 (3 documents)

    Export disorders for SLC27A2 gene to outside databases

    Publications
    for SLC27A2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC27A2 gene, integrated from 9 sources (see all 51):
    (articles sorted by number of sources associating them with SLC27A2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of human fatty-acid-coenzyme A ligase, very long-chain 1 gene (FACVL1) to human chromosome band 15q21.2 by fluorescence in situ hybridization. (PubMed id 9730624)1, 3, 9 Wakui K....Fukushima Y. (1998)
    2. Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism. (PubMed id 10198260)1, 2, 9 Steinberg S.J.... Watkins P.A. (1999)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling. (PubMed id 11980911)1, 2 Mihalik S.J....Watkins P.A. (2002)
    5. Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein. (PubMed id 10479480)1, 9 Steinberg S.J.... Watkins P.A. (1999)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Human fatty acid transport protein 2a/very long chain acyl-CoA synthetase 1 (FATP2a/Acsvl1) has a preference in mediating the channe ling of exogenous n-3 fatty acids into phosphatidylinositol. (PubMed id 21768100)1 Melton E.M....Black P.N. (2011)
    10. The expression and function of fatty acid transport pr otein-2 and -4 in the murine placenta. (PubMed id 22028793)1 Mishima T....Sadovsky Y. (2011)

    External Searches for SLC27A2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SLC27A2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11001 HGNC: 10996 AceView: SLC27A2 Ensembl:ENSG00000140284 euGenes: HUgn11001
    ECgene: SLC27A2 Kegg: 11001 H-InvDB: SLC27A2

    Other Databases showing SLC27A2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC27A2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC27A2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC27A2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC27A2 gene:
    Search GeneIP for patents involving SLC27A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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