Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC27A2 Gene

Aliases for SLC27A2 Gene

  • Solute Carrier Family 27 (Fatty Acid Transporter), Member 2 2 3
  • FACVL1 3 4 6
  • VLACS 3 4 6
  • Fatty-Acid-Coenzyme A Ligase, Very Long-Chain 1 3 4
  • Very Long-Chain-Fatty-Acid-CoA Ligase 3 4
  • Long-Chain-Fatty-Acid--CoA Ligase 3 4
  • Solute Carrier Family 27 Member 2 3 4
  • Fatty Acid Transport Protein 2 3 4
  • THCA-CoA Ligase 3 4
  • ACSVL1 3 4
  • FATP-2 3 4
  • FATP2 3 4
  • VLCS 3 4
  • Very Long-Chain Fatty-Acid-Coenzyme A Ligase 1 3
  • Very Long-Chain Acyl-CoA Synthetase 3
  • Very-Long-Chain Acyl-CoA Synthetase 3
  • EC 6.2.1.7 63
  • EC 6.2.1.- 4
  • EC 6.2.1.3 4
  • HsT17226 3
  • EC 6.2.1 63
  • HFACVL1 3

External Ids for SLC27A2 Gene

Previous HGNC Symbols for SLC27A2 Gene

  • FACVL1

Previous GeneCards Identifiers for SLC27A2 Gene

  • GC15U990072
  • GC15P043520
  • GC15P048053
  • GC15P048190
  • GC15P048261
  • GC15P050474
  • GC15P027305

Summaries for SLC27A2 Gene

Entrez Gene Summary for SLC27A2 Gene

  • The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

GeneCards Summary for SLC27A2 Gene

SLC27A2 (Solute Carrier Family 27 (Fatty Acid Transporter), Member 2) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include receptor binding and long-chain fatty acid-CoA ligase activity. An important paralog of this gene is SLC27A1.

UniProtKB/Swiss-Prot for SLC27A2 Gene

  • Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity).

Gene Wiki entry for SLC27A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC27A2 Gene

Genomics for SLC27A2 Gene

Regulatory Elements for SLC27A2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC27A2 Gene

Start:
50,182,196 bp from pter
End:
50,236,395 bp from pter
Size:
54,200 bases
Orientation:
Plus strand

Genomic View for SLC27A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC27A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC27A2 Gene

Proteins for SLC27A2 Gene

  • Protein details for SLC27A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14975-S27A2_HUMAN
    Recommended name:
    Very long-chain acyl-CoA synthetase
    Protein Accession:
    O14975
    Secondary Accessions:
    • A8K2J7
    • Q53FY6
    • Q6PF09

    Protein attributes for SLC27A2 Gene

    Size:
    620 amino acids
    Molecular mass:
    70312 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC27A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC27A2 Gene

Proteomics data for SLC27A2 Gene at MOPED

Selected DME Specific Peptides for SLC27A2 Gene

Post-translational modifications for SLC27A2 Gene

  • Ubiquitination at Lys398
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC27A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for SLC27A2 Gene

Gene Families for SLC27A2 Gene

HGNC:
  • ACS :Acyl-CoA synthetase family
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC27A2 Gene

Suggested Antigen Peptide Sequences for SLC27A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14975

UniProtKB/Swiss-Prot:

S27A2_HUMAN :
  • O14975
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with SLC27A2: view

Function for SLC27A2 Gene

Molecular function for SLC27A2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA.
UniProtKB/Swiss-Prot Function: Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity).

Enzyme Numbers (IUBMB) for SLC27A2 Gene

Gene Ontology (GO) - Molecular Function for SLC27A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004467 long-chain fatty acid-CoA ligase activity IDA 10198260
GO:0005102 receptor binding IPI 20178365
GO:0005524 ATP binding IEA --
GO:0015245 fatty acid transporter activity IEA --
genes like me logo Genes that share ontologies with SLC27A2: view

Phenotypes for SLC27A2 Gene

MGI mutant phenotypes for SLC27A2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SLC27A2: view

Animal Models for SLC27A2 Gene

MGI Knock Outs for SLC27A2:

Animal Model Products

CRISPR Products

miRNA for SLC27A2 Gene

miRTarBase miRNAs that target SLC27A2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC27A2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for SLC27A2 Gene

Localization for SLC27A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC27A2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein. Note=Peripheral membrane associated with the lumenal side of peroxisomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC27A2 Gene COMPARTMENTS Subcellular localization image for SLC27A2 gene
Compartment Confidence
endoplasmic reticulum 5
peroxisome 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for SLC27A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005777 peroxisome --
GO:0005778 peroxisomal membrane TAS --
GO:0005779 integral component of peroxisomal membrane IDA 10198260
GO:0005783 endoplasmic reticulum --
genes like me logo Genes that share ontologies with SLC27A2: view

Pathways for SLC27A2 Gene

genes like me logo Genes that share pathways with SLC27A2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for SLC27A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000038 very long-chain fatty acid metabolic process --
GO:0001561 fatty acid alpha-oxidation TAS --
GO:0001676 long-chain fatty acid metabolic process IDA 22022213
GO:0006635 fatty acid beta-oxidation IDA 10198260
GO:0006699 bile acid biosynthetic process TAS --
genes like me logo Genes that share ontologies with SLC27A2: view

Compounds for SLC27A2 Gene

(34) HMDB Compounds for SLC27A2 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(5) Novoseek inferred chemical compound relationships for SLC27A2 Gene

Compound -log(P) Hits PubMed IDs
lignoceric acid 84.8 1
acyl-coa 81.4 14
phytanic acid 72.4 1
fatty acid 61.8 8
atp 12 1
genes like me logo Genes that share compounds with SLC27A2: view

Transcripts for SLC27A2 Gene

Unigene Clusters for SLC27A2 Gene

Solute carrier family 27 (fatty acid transporter), member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC27A2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC27A2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC27A2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
SP1: - - - -
SP2: - - - - -
SP3: -
SP4:
SP5:

Relevant External Links for SLC27A2 Gene

GeneLoc Exon Structure for
SLC27A2
ECgene alternative splicing isoforms for
SLC27A2

Expression for SLC27A2 Gene

mRNA expression in normal human tissues for SLC27A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC27A2 Gene

This gene is overexpressed in Liver (29.1) and Kidney - Cortex (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC27A2 Gene

SOURCE GeneReport for Unigene cluster for SLC27A2 Gene Hs.11729

mRNA Expression by UniProt/SwissProt for SLC27A2 Gene

O14975-S27A2_HUMAN
Tissue specificity: Expressed in liver, kidney, placenta and pancreas.
genes like me logo Genes that share expressions with SLC27A2: view

In Situ Assay Products

Orthologs for SLC27A2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC27A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC27A2 35
  • 99.57 (n)
  • 99.35 (a)
SLC27A2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC27A2 35
  • 86.34 (n)
  • 85.16 (a)
SLC27A2 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC27A2 35
  • 86.77 (n)
  • 84.68 (a)
SLC27A2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc27a2 35
  • 82.42 (n)
  • 82.42 (a)
Slc27a2 16
Slc27a2 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC27A2 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC27A2 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc27a2 35
  • 82.1 (n)
  • 82.26 (a)
chicken
(Gallus gallus)
Aves SLC27A2 35
  • 59.55 (n)
  • 56.55 (a)
lizard
(Anolis carolinensis)
Reptilia SLC27A2 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494612 35
  • 63.36 (n)
  • 62.86 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.257 35
zebrafish
(Danio rerio)
Actinopterygii Dr.19084 35
SLC27A2 (2 of 3) 36
  • 51 (a)
OneToMany
SLC27A2 (3 of 3) 36
  • 54 (a)
OneToMany
slc27a2b 36
  • 55 (a)
OneToMany
zgc:101540 35
  • 60.08 (n)
  • 58.29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAT1 36
  • 31 (a)
OneToMany
FAT1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for SLC27A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC27A2 Gene

ENSEMBL:
Gene Tree for SLC27A2 (if available)
TreeFam:
Gene Tree for SLC27A2 (if available)

Paralogs for SLC27A2 Gene

Paralogs for SLC27A2 Gene

Selected SIMAP similar genes for SLC27A2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC27A2: view

Variants for SLC27A2 Gene

Sequence variations from dbSNP and Humsavar for SLC27A2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs933855 -- 50,191,382(+) ctttg(C/G)ccaag intron-variant
rs933856 -- 50,191,539(+) agact(C/T)ctgtt intron-variant
rs933857 -- 50,197,845(+) TGCGG(A/G)AACTG intron-variant
rs1124609 -- 50,193,820(+) TTATT(A/G)TCTTA intron-variant
rs1127911 -- 50,226,044(+) GTCCG(A/T)GATGA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for SLC27A2 Gene

Variant ID Type Subtype PubMed ID
nsv483038 CNV Gain 15286789
nsv904209 CNV Loss 21882294
nsv1531 CNV Insertion 18451855
nsv507779 CNV Insertion 20534489

Relevant External Links for SLC27A2 Gene

HapMap Linkage Disequilibrium report
SLC27A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC27A2 Gene

Disorders for SLC27A2 Gene

(1) University of Copenhagen DISEASES for SLC27A2 Gene

(1) Novoseek inferred disease relationships for SLC27A2 Gene

Disease -log(P) Hits PubMed IDs
adrenoleukodystrophy 89.7 6

Relevant External Links for SLC27A2

Genetic Association Database (GAD)
SLC27A2
Human Genome Epidemiology (HuGE) Navigator
SLC27A2
genes like me logo Genes that share disorders with SLC27A2: view

No data available for UniProtKB/Swiss-Prot for SLC27A2 Gene

Publications for SLC27A2 Gene

  1. Assignment of human fatty-acid-coenzyme A ligase, very long-chain 1 gene (FACVL1) to human chromosome band 15q21.2 by fluorescence in situ hybridization. (PMID: 9730624) Wakui K. … Fukushima Y. (Cytogenet. Cell Genet. 1998) 2 3 23
  2. Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism. (PMID: 10198260) Steinberg S.J. … Watkins P.A. (Biochem. Biophys. Res. Commun. 1999) 3 4 23
  3. Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling. (PMID: 11980911) Mihalik S.J. … Watkins P.A. (J. Biol. Chem. 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein. (PMID: 10479480) Steinberg S.J. … Watkins P.A. (Mol. Genet. Metab. 1999) 3 23

Products for SLC27A2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SLC27A2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SLC27A2
    • Block miRNA regulation of SLC27A2 using miScript Target Protectors

    Sources for SLC27A2 Gene

    Back to Top

    Content