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SLC27A2 Gene

protein-coding   GIFtS: 64
GCID: GC15P050474

Solute Carrier Family 27 (Fatty Acid Transporter), Member...


(Previous symbol: FACVL1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 27 (Fatty Acid Transporter), Member 21 2     VLCS2 3
FACVL11 2 3 5     THCA-CoA Ligase2 3
VLACS2 3 5     HsT172262
Fatty Acid Transport Protein 22 3     hFACVL12
Fatty-Acid-Coenzyme A Ligase, Very Long-Chain 12 3     Very Long-Chain Acyl-CoA Synthetase2
Long-Chain-Fatty-Acid--CoA Ligase2 3     Very Long-Chain Fatty-Acid-Coenzyme A Ligase 12
Solute Carrier Family 27 Member 22 3     Very-Long-Chain Acyl-CoA Synthetase2
Very Long-Chain-Fatty-Acid-CoA Ligase2 3     EC 6.2.1.-3
ACSVL12 3     EC 6.2.1.33
FATP-22 3     EC 6.2.18
FATP22 3     EC 6.2.1.78

External Ids:    HGNC: 109961   Entrez Gene: 110012   Ensembl: ENSG000001402847   OMIM: 6032475   UniProtKB: O149753   

Export aliases for SLC27A2 gene to outside databases

Previous GC identifers: GC15U990072 GC15P043520 GC15P048053 GC15P048190 GC15P048261 GC15P027305


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC27A2 Gene:
The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although
differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this
family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid
biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain
fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and
kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased
peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked
adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Apr 2009)

GeneCards Summary for SLC27A2 Gene:
SLC27A2 (solute carrier family 27 (fatty acid transporter), member 2) is a protein-coding gene. GO annotations related to this gene include long-chain fatty acid-CoA ligase activity and receptor binding. An important paralog of this gene is SLC27A5.

UniProtKB/Swiss-Prot: S27A2_HUMAN, O14975
Function: Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of
bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs.
In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic
acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In
vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid
metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity)

Gene Wiki entry for SLC27A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC27A2 gene promoter:
         Sp1   Pax-5   STAT5A   CUTL1   AP-4   C/EBPalpha   HEN1   CHOP-10   SEF-1 (1)   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC27A2 promoter sequence
   Search Chromatin IP Primers for SLC27A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC27A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q21.2

SLC27A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC27A2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P050474:  view genomic region     (about GC identifiers)

Start:
50,474,393 bp from pter      End:
50,528,592 bp from pter
Size:
54,200 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: S27A2_HUMAN, O14975 (See protein sequence)
Recommended Name: Very long-chain acyl-CoA synthetase  
Size: 620 amino acids; 70312 Da
Secondary accessions: A8K2J7 Q53FY6 Q6PF09
Alternative splicing: 2 isoforms:  O14975-1   O14975-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC27A2: NX_O14975

Explore proteomics data for SLC27A2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys398
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for SLC27A2 (O14975)
     RWKGENV  TSGTTGLPKA 


    See SLC27A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001153101.1  NP_003636.2  

    ENSEMBL proteins: 
     ENSP00000267842   ENSP00000370289   ENSP00000444549  
    Reactome Protein details: O14975

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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SLC27A2 

     
    antibodies-online proteins for SLC27A2 (2 products) 

     
    antibodies-online peptides for SLC27A2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers
    ACS: Acyl-CoA synthetase family

    IUPHAR Guide to PHARMACOLOGY protein family classification: Fatty acid transport protein 2
    SLC27 family of fatty acid transporters

    3 InterPro protein domains:
     IPR025110 AMP-bd_C
     IPR020845 AMP-binding_CS
     IPR000873 AMP-dep_Synth/Lig

    Graphical View of Domain Structure for InterPro Entry O14975

    ProtoNet protein and cluster: O14975

    1 Blocks protein domain: IPB000873 AMP-binding signature

    UniProtKB/Swiss-Prot: S27A2_HUMAN, O14975
    Similarity: Belongs to the ATP-dependent AMP-binding enzyme family


    Find genes that share domains with SLC27A2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S27A2_HUMAN, O14975
    Function: Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of
    bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs.
    In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic
    acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In
    vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid
    metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity)
    Catalytic activity: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA
    Catalytic activity: ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA

         Enzyme Numbers (IUBMB): EC 6.2.12 EC 6.2.1.72 EC 6.2.1.31 EC 6.2.1.-1

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004467long-chain fatty acid-CoA ligase activity IDA10198260
    GO:0005102receptor binding IPI--
    GO:0005524ATP binding IEA--
    GO:0015245fatty acid transporter activity IEA--
         
    Find genes that share ontologies with SLC27A2           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc27a2):
     cellular  normal 

    Find genes that share phenotypes with SLC27A2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Slc27a2tm1Kds for SLC27A2

       genOway: Develop your customized and physiologically relevant rodent model for SLC27A2

    miRNA
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    miRTarBase miRNAs that target SLC27A2:
    hsa-let-7b-5p (MIRT032206), hsa-mir-155-5p (MIRT020494)

    Block miRNA regulation of human, mouse, rat SLC27A2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SLC27A2
    SwitchGear 3'UTR luciferase reporter plasmidSLC27A2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC27A2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S27A2_HUMAN, O14975: Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass
    membrane protein. Note=Peripheral membrane associated with the lumenal side of peroxisomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    peroxisome5
    mitochondrion2

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005777peroxisome ----
    GO:0005778peroxisomal membrane TAS--
    GO:0005779integral component of peroxisomal membrane IDA10198260
    GO:0005783endoplasmic reticulum ----

    Find genes that share ontologies with SLC27A2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC27A2 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Synthesis of bile acids and bile salts
    Synthesis of bile acids and bile salts0.88
    bile acid biosynthesis, neutral pathway0.48
    Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol0.88
    Synthesis of bile acids and bile salts via 24-hydroxycholesterol0.00
    Bile acid and bile salt metabolism0.73
    2PPAR signaling pathway
    fatty acid beta-oxidation VI (peroxisome)0.00
    PPAR signaling pathway
    3stearate biosynthesis I (animals)
    stearate biosynthesis I (animals)0.35
    fatty acid beta-oxidation I0.30
    gamma-linolenate biosynthesis II (animals)0.35
    fatty acid activation0.00
    4Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    5Peroxisomal lipid metabolism
    Peroxisomal lipid metabolism
    Alpha-oxidation of phytanate0.00


    Find genes that share SuperPaths with SLC27A2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected BioSystems Pathways for SLC27A2 (see all 7)
        stearate biosynthesis I (animals)
    gamma-linolenate biosynthesis II (animals)
    bile acid biosynthesis, neutral pathway
    fatty acid alpha-oxidation II
    fatty acid beta-oxidation VI (peroxisome)


    3 Reactome Pathways for SLC27A2
        Alpha-oxidation of phytanate
    Synthesis of bile acids and bile salts via 24-hydroxycholesterol
    Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

    1 PharmGKB Pathway for SLC27A2
        Metformin Pathway, Pharmacokinetics

    2 Kegg Pathways  (Kegg details for SLC27A2):
        PPAR signaling pathway
    Peroxisome

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC27A2: 
              Fatty Acid Metabolism in human mouse rat
              PPAR Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLC27A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SLC27A2 (O149752, 3 ENSP000002678424) via UniProtKB, MINT, STRING, and/or I2D (see all 104)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3MINT-3319021 I2D: score=1 
    AGPAT1Q999433, ENSP000003374634I2D: score=4 STRING: ENSP00000337463
    ENSG00000235758Q999433, ENSP000004012874I2D: score=4 STRING: ENSP00000401287
    ENSG00000236873Q999433, ENSP000003958634I2D: score=4 STRING: ENSP00000395863
    ENSG00000206324Q999433I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000038very long-chain fatty acid metabolic process ----
    GO:0001561fatty acid alpha-oxidation TAS--
    GO:0001676long-chain fatty acid metabolic process IDA--
    GO:0006635fatty acid beta-oxidation IDA10198260
    GO:0006699bile acid biosynthetic process TAS--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC27A2 (S27A2)

    Selected HMDB Compounds for SLC27A2 (see all 34)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    20-COOH-leukotriene E420-COOH-LTE4 (see all 3)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    6,9,12,15,18,21-Tetracosahexaenoic acidall-cis-6,9,12,15,18,21-tetracosahexaenoate (see all 8)----

    5 Novoseek inferred chemical compound relationships for SLC27A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lignoceric acid 84.8 1 8978480 (1)
    acyl-coa 81.4 15 7818538 (2), 11330068 (2), 9660783 (2), 10227685 (1) (see all 11)
    phytanic acid 72.4 1 8978480 (1)
    fatty acid 61.8 10 9660783 (3), 20054868 (1), 9642112 (1), 12454267 (1) (see all 6)
    atp 12 1 12048192 (1)



    Find genes that share compounds with SLC27A2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC27A2 gene (2 alternative transcripts): 
    NM_001159629.1  NM_003645.3  

    Unigene Cluster for SLC27A2:

    Solute carrier family 27 (fatty acid transporter), member 2
    Hs.11729  [show with all ESTs]
    Unigene Representative Sequence: NM_003645
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000267842(uc001zxw.3 uc010bes.3) ENST00000380902 ENST00000544960(uc001zxx.3)
    ENST00000559938
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC27A2
      QuantiFast Probe-based Assays in human, mouse, rat SLC27A2

    Additional mRNA sequence: 

    AF096290.1 AK123905.1 AK222859.1 AK223145.1 AK290262.1 BC057770.1 D88308.1 

    8 DOTS entries:

    DT.410735  DT.121026393  DT.101981412  DT.121026465  DT.101981413  DT.100821229  DT.97841642  DT.121026433 

    Selected AceView cDNA sequences (see all 122):

    BF434433 CB161516 AI912985 BF509295 BM982730 BQ323123 BC057770 AA417177 
    BM980042 BE048793 BM793334 CA414604 BM980690 CB132406 BG698883 AI636008 
    NM_003645 BF509346 BX100106 BQ950984 AF096290 CR602275 BM760972 AW241618 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC27A2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
    SP1:              -           -     -                             -                                       
    SP2:              -           -     -     -                       -                                       
    SP3:                                                              -                                       
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for SLC27A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SLC27A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTCCATCA
    SLC27A2 Expression
    About this image


    SLC27A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Kidney (Urinary System)    fully expand to see all 6 entries
             Loop of Henle Cells Loop of Henle
             Metanephros
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             Liver Lobule
     
     Epithelial Cells
             Loop of Henle Cells Loop of Henle
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Thoracic Perivascular Adipose
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
    SLC27A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC27A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.11729

    UniProtKB/Swiss-Prot: S27A2_HUMAN, O14975
    Tissue specificity: Expressed in liver, kidney, placenta and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC27A2: 
              Fatty Acid Metabolism in human mouse rat
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC27A2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc27a21 , 5 solute carrier family 27 (fatty acid transporter), more1, 5 82.42(n)1
    82.42(a)1
      2 (61.76 cM)5
    264581  NM_011978.21  NP_036108.21 
     1265524075 
    chicken
    (Gallus gallus)
    Aves SLC27A21 solute carrier family 27 (fatty acid transporter), more 59.55(n)
    56.55(a)
      426354  XM_424010.4  XP_424010.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLC27A26
    solute carrier family 27 (fatty acid transporter),...
    47(a)
    1 ↔ 1
    AAWZ02037934(7667-12637)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC041746.12   -- 76.68(n)    BC041746.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.190842 Transcribed sequence with moderate similarity to protein more 74.64(n)    BQ617699.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FAT1(YBR041W)4 Very long chain fatty acyl-CoA synthetase and long more   --   2(318266-320275) 852329  NP_009597.2 


    ENSEMBL Gene Tree for SLC27A2 (if available)
    TreeFam Gene Tree for SLC27A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC27A2 gene
    SLC27A52  SLC27A42  SLC27A12  SLC27A32  SLC27A62  
    6 SIMAP similar genes for SLC27A2 using alignment to 2 protein entries:     S27A2_HUMAN (see all proteins):
    SLC27A6    SLC27A3    SLC27A5    SLC27A4    FLJ00336    SLC27A1

    Find genes that share paralogs with SLC27A2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC27A2 (see all 1216)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1840517951,2
    --50472561(+) AGGTGA/TCAGCA 2 -- us2k10--------
    rs802736431,2
    C,F--50472567(+) CAGCAT/CTTAAA 2 -- us2k11Minor allele frequency- C:0.05EA 120
    rs287262251,2
    C,F--50472641(+) AGCTTG/AGGTCT 2 -- us2k11Minor allele frequency- A:0.08WA 118
    rs169634001,2
    C,F,H--50472760(+) AAAAGA/TGAAGA 2 -- us2k1 trp317Minor allele frequency- N:0.00NA EA NS WA CSA 1416
    rs1478391741,2
    --50472881(+) GAATGA/GTTTCT 2 -- us2k10--------
    rs118547611,2
    C,F,H--50472889(+) TCTGTC/GGGGCC 2 -- us2k117Minor allele frequency- G:0.07NA NS EA 1230
    rs71765011,2
    C,F,A,H--50473041(+) GGATAC/G/TGAAAA 2 -- us2k127EA NA NS WA CSA 2568
    rs740149271,2
    C,F--50473061(+) AAAACG/AGCAGG 2 -- us2k14Minor allele frequency- A:0.14WA CSA NA 242
    rs1872352171,2
    --50473113(+) CACACA/GCCGAA 2 -- us2k10--------
    rs71768661,2
    H--50473278(+) CCTTTC/TTTGTC 2 -- us2k1 trp34Minor allele frequency- T:0.00NS EA 418

    HapMap Linkage Disequilibrium report for SLC27A2 (50474393 - 50528592 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SLC27A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1531CNV Insertion18451855
    nsv507779CNV Insertion20534489
    nsv904209CNV Loss21882294
    nsv483038CNV Gain15286789

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC27A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC27A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603247    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for SLC27A2:
    Adrenoleukodystrophy

    Find genes that share disorders with SLC27A2           About GenesLikeMe

    1 Novoseek inferred disease relationship for SLC27A2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adrenoleukodystrophy 89.7 6 9660783 (2), 7818538 (1), 9256488 (1), 10479480 (1) (see all 5)

    Genetic Association Database (GAD): SLC27A2
    Human Genome Epidemiology (HuGE) Navigator: SLC27A2 (3 documents)

    Export disorders for SLC27A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC27A2 gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with SLC27A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of human fatty-acid-coenzyme A ligase, very long-chain 1 gene (FACVL1) to human chromosome band 15q21.2 by fluorescence in situ hybridization. (PubMed id 9730624)1, 3, 9 Wakui K....Fukushima Y. (Cytogenet. Cell Genet. 1998)
    2. Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism. (PubMed id 10198260)1, 2, 9 Steinberg S.J.... Watkins P.A. (Biochem. Biophys. Res. Commun. 1999)
    3. Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. (PubMed id 17998437)1, 4 Li H....Roses A.D. (Arch. Neurol. 2008)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling. (PubMed id 11980911)1, 2 Mihalik S.J....Watkins P.A. (J. Biol. Chem. 2002)
    6. Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein. (PubMed id 10479480)1, 9 Steinberg S.J.... Watkins P.A. (Mol. Genet. Metab. 1999)
    7. Overexpression of human fatty acid transport protein 2/very long chain acyl-CoA synthetase 1 (FATP2/Acsvl1) reveals distinct patterns of trafficking of exogenous fatty acids. (PubMed id 24113382)1 Melton E.M....Black P.N. (Biochem. Biophys. Res. Commun. 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11001 HGNC: 10996 AceView: SLC27A2 Ensembl:ENSG00000140284 euGenes: HUgn11001
    ECgene: SLC27A2 Kegg: 11001 H-InvDB: SLC27A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC27A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC27A2 gene:
    Search GeneIP for patents involving SLC27A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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