Aliases for SLC27A1 Gene
External Ids for SLC27A1 Gene
Previous GeneCards Identifiers for SLC27A1 Gene
GeneCards Summary for SLC27A1 Gene
SLC27A1 (Solute Carrier Family 27 (Fatty Acid Transporter), Member 1) is a Protein Coding gene. Diseases associated with SLC27A1 include ichthyosis prematurity syndrome and obesity. Among its related pathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include protein homodimerization activity and long-chain fatty acid-CoA ligase activity. An important paralog of this gene is SLC27A2.
UniProtKB/Swiss-Prot for SLC27A1 Gene
Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (By similarity).