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Aliases for SLC27A1 Gene

Aliases for SLC27A1 Gene

  • Solute Carrier Family 27 Member 1 2 3 4
  • Solute Carrier Family 27 (Fatty Acid Transporter), Member 1 2 3 5
  • Fatty Acid Transport Protein 1 3 4
  • ACSVL5 3 4
  • FATP-1 3 4
  • FATP1 3 4
  • EC 6.2.1.- 4
  • EC 6.2.1 63
  • FATP 3

External Ids for SLC27A1 Gene

Previous GeneCards Identifiers for SLC27A1 Gene

  • GC19U990163
  • GC19P017442
  • GC19P017579
  • GC19P017146
  • GC19P017553
  • GC19P017701

Summaries for SLC27A1 Gene

GeneCards Summary for SLC27A1 Gene

SLC27A1 (Solute Carrier Family 27 Member 1) is a Protein Coding gene. Diseases associated with SLC27A1 include ichthyosis prematurity syndrome and obesity. Among its related pathways are Translation Insulin regulation of translation and PPAR signaling pathway. GO annotations related to this gene include protein homodimerization activity and long-chain fatty acid-CoA ligase activity. An important paralog of this gene is SLC27A2.

UniProtKB/Swiss-Prot for SLC27A1 Gene

  • Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (By similarity).

Gene Wiki entry for SLC27A1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC27A1 Gene

Genomics for SLC27A1 Gene

Regulatory Elements for SLC27A1 Gene

Enhancers for SLC27A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC27A1 on UCSC Golden Path with GeneCards custom track

Promoters for SLC27A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC27A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC27A1 Gene

Chromosome:
19
Start:
17,468,769 bp from pter
End:
17,506,168 bp from pter
Size:
37,400 bases
Orientation:
Plus strand

Genomic View for SLC27A1 Gene

Genes around SLC27A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC27A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC27A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC27A1 Gene

Proteins for SLC27A1 Gene

  • Protein details for SLC27A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PCB7-S27A1_HUMAN
    Recommended name:
    Long-chain fatty acid transport protein 1
    Protein Accession:
    Q6PCB7
    Secondary Accessions:
    • A6NIH2
    • B7Z662

    Protein attributes for SLC27A1 Gene

    Size:
    646 amino acids
    Molecular mass:
    71108 Da
    Quaternary structure:
    • Self-associates. May function as a homodimer (By similarity).
    Miscellaneous:
    • FATP1-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which is associated with disturbed fatty acid metabolism and homeostasis, such as obesity.

    Alternative splice isoforms for SLC27A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC27A1 Gene

Proteomics data for SLC27A1 Gene at MOPED

Post-translational modifications for SLC27A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC27A1 Gene

Domains & Families for SLC27A1 Gene

Protein Domains for SLC27A1 Gene

Suggested Antigen Peptide Sequences for SLC27A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6PCB7

UniProtKB/Swiss-Prot:

S27A1_HUMAN :
  • Belongs to the ATP-dependent AMP-binding enzyme family.
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with SLC27A1: view

Function for SLC27A1 Gene

Molecular function for SLC27A1 Gene

UniProtKB/Swiss-Prot Function:
Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (By similarity).

Enzyme Numbers (IUBMB) for SLC27A1 Gene

genes like me logo Genes that share phenotypes with SLC27A1: view

Animal Models for SLC27A1 Gene

MGI Knock Outs for SLC27A1:

Animal Model Products

CRISPR Products

miRNA for SLC27A1 Gene

miRTarBase miRNAs that target SLC27A1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC27A1 Gene

Localization for SLC27A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC27A1 Gene

Cell membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane protein. Cytoplasm. Note=Plasma membrane and intracellular membranes, at least in adipocytes. Predominantly cytoplasmic in myocytes (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC27A1 Gene COMPARTMENTS Subcellular localization image for SLC27A1 gene
Compartment Confidence
plasma membrane 5
mitochondrion 4
endoplasmic reticulum 3
extracellular 2
peroxisome 2
cytosol 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SLC27A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with SLC27A1: view

Pathways & Interactions for SLC27A1 Gene

genes like me logo Genes that share pathways with SLC27A1: view

Gene Ontology (GO) - Biological Process for SLC27A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006646 phosphatidylethanolamine biosynthetic process IMP 19523918
GO:0006654 phosphatidic acid biosynthetic process IMP 19523918
GO:0006661 phosphatidylinositol biosynthetic process IMP 19523918
GO:0009409 response to cold IEA --
GO:0015908 fatty acid transport IEA --
genes like me logo Genes that share ontologies with SLC27A1: view

No data available for SIGNOR curated interactions for SLC27A1 Gene

Drugs & Compounds for SLC27A1 Gene

(12) Drugs for SLC27A1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22
Propionyl-CoA Experimental Pharma 0
Stearic acid Experimental Pharma 0
Tridecanoic acid Experimental Pharma 0

(45) Additional Compounds for SLC27A1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with SLC27A1: view

Transcripts for SLC27A1 Gene

Unigene Clusters for SLC27A1 Gene

Solute carrier family 27 (fatty acid transporter), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC27A1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
SP1:
SP2:
SP3: - -
SP4: -
SP5: - -
SP6:
SP7:

Relevant External Links for SLC27A1 Gene

GeneLoc Exon Structure for
SLC27A1
ECgene alternative splicing isoforms for
SLC27A1

Expression for SLC27A1 Gene

mRNA expression in normal human tissues for SLC27A1 Gene

Protein differential expression in normal tissues from HIPED for SLC27A1 Gene

This gene is overexpressed in Nasal epithelium (34.0) and Testis (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC27A1 Gene



SOURCE GeneReport for Unigene cluster for SLC27A1 Gene Hs.363138

mRNA Expression by UniProt/SwissProt for SLC27A1 Gene

Q6PCB7-S27A1_HUMAN
Tissue specificity: Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver.
genes like me logo Genes that share expression patterns with SLC27A1: view

Protein tissue co-expression partners for SLC27A1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for SLC27A1 Gene

Orthologs for SLC27A1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC27A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC27A1 35
  • 88.96 (n)
  • 92.57 (a)
SLC27A1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC27A1 35
  • 89.42 (n)
  • 92.72 (a)
SLC27A1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc27a1 35
  • 84.52 (n)
  • 89.47 (a)
Slc27a1 16
Slc27a1 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc27a1 35
  • 84.06 (n)
  • 89.63 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC27A1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC27A1 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC27A1 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC27A1 35
  • 71.93 (n)
  • 73.37 (a)
SLC27A1 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC27A1 36
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc27a1a 35
  • 64.81 (n)
  • 65.94 (a)
wufc10e12 35
slc27a1a 36
  • 66 (a)
OneToMany
slc27a1b 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG30194 36
  • 42 (a)
ManyToMany
CG3394 36
  • 38 (a)
ManyToMany
Fatp 36
  • 40 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea acs-20 36
  • 38 (a)
ManyToMany
acs-22 36
  • 40 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAT1 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9398 36
  • 42 (a)
OneToMany
Species with no ortholog for SLC27A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC27A1 Gene

ENSEMBL:
Gene Tree for SLC27A1 (if available)
TreeFam:
Gene Tree for SLC27A1 (if available)

Paralogs for SLC27A1 Gene

Paralogs for SLC27A1 Gene

(6) SIMAP similar genes for SLC27A1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC27A1: view

Variants for SLC27A1 Gene

Sequence variations from dbSNP and Humsavar for SLC27A1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7256418 -- 17,476,888(+) Gtttt(G/T)ttttt intron-variant
rs12977261 -- 17,468,169(+) ctttc(C/T)tttct upstream-variant-2KB
rs7409155 -- 17,485,190(+) tgttt(C/T)ctttt intron-variant
rs7507477 -- 17,467,290(+) agaga(A/G)agaga upstream-variant-2KB
rs12979071 -- 17,502,650(+) caccc(C/G)gccTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC27A1 Gene

Variant ID Type Subtype PubMed ID
nsv911182 CNV Loss 21882294
nsv833768 CNV Loss 17160897
dgv3761n71 CNV Loss 21882294
nsv911203 CNV Loss 21882294
nsv911205 CNV Loss 21882294
dgv3762n71 CNV Loss 21882294
esv2677036 CNV Deletion 23128226

Variation tolerance for SLC27A1 Gene

Residual Variation Intolerance Score: 12.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.13; 38.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC27A1 Gene

HapMap Linkage Disequilibrium report
SLC27A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC27A1 Gene

Disorders for SLC27A1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC27A1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ichthyosis prematurity syndrome
  • ichthyosis congenita iv
obesity
  • obesity, association with
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC27A1

Genetic Association Database (GAD)
SLC27A1
Human Genome Epidemiology (HuGE) Navigator
SLC27A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC27A1
genes like me logo Genes that share disorders with SLC27A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC27A1 Gene

Publications for SLC27A1 Gene

  1. The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression. (PMID: 10873384) Martin G. … Auwerx J. (Genomics 2000) 2 3 4 23 67
  2. FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down- regulates sphingomyelin and cholesterol metabolism in growing 293 cells. (PMID: 12235169) Hatch G.M. … Bernlohr D.A. (J. Lipid Res. 2002) 3 23 26
  3. FATP1 inhibits 11-cis retinol formation via interaction with the visual cycle retinoid isomerase RPE65 and lecithin:retinol acyltransferase. (PMID: 20356843) Guignard T.J. … Brabet P. (J. Biol. Chem. 2010) 3 23
  4. FATP1 localizes to mitochondria and enhances pyruvate dehydrogenase activity in skeletal myotubes. (PMID: 19361580) Guitart M. … GarcA-a-MartA-nez C. (Mitochondrion 2009) 3 23
  5. Regulation of cardiolipin biosynthesis by fatty acid transport protein-1 IN HEK 293 cells. (PMID: 19523918) Mitchell R.W. … Hatch G.M. (Biochim. Biophys. Acta 2009) 3 23

Products for SLC27A1 Gene

Sources for SLC27A1 Gene

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