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Aliases for SLC27A1 Gene

Aliases for SLC27A1 Gene

  • Solute Carrier Family 27 (Fatty Acid Transporter), Member 1 2 3
  • FATP1 3 4 6
  • Solute Carrier Family 27 Member 1 3 4
  • Fatty Acid Transport Protein 1 3 4
  • ACSVL5 3 4
  • FATP-1 3 4
  • FATP 3 6
  • Long-Chain Fatty Acid Transport Protein 1 3
  • EC 6.2.1.- 4
  • EC 6.2.1 63

External Ids for SLC27A1 Gene

Previous GeneCards Identifiers for SLC27A1 Gene

  • GC19U990163
  • GC19P017442
  • GC19P017579
  • GC19P017146

Summaries for SLC27A1 Gene

GeneCards Summary for SLC27A1 Gene

SLC27A1 (Solute Carrier Family 27 (Fatty Acid Transporter), Member 1) is a Protein Coding gene. Diseases associated with SLC27A1 include ichthyosis prematurity syndrome and wrinkles. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include protein homodimerization activity and very long-chain fatty acid-CoA ligase activity. An important paralog of this gene is SLC27A2.

UniProtKB/Swiss-Prot for SLC27A1 Gene

  • Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (By similarity).

Gene Wiki entry for SLC27A1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC27A1 Gene

Genomics for SLC27A1 Gene

Regulatory Elements for SLC27A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC27A1 Gene

Start:
17,405,703 bp from pter
End:
17,506,168 bp from pter
Size:
100,466 bases
Orientation:
Plus strand

Genomic View for SLC27A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC27A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC27A1 Gene

Proteins for SLC27A1 Gene

  • Protein details for SLC27A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PCB7-S27A1_HUMAN
    Recommended name:
    Long-chain fatty acid transport protein 1
    Protein Accession:
    Q6PCB7
    Secondary Accessions:
    • A6NIH2
    • B7Z662

    Protein attributes for SLC27A1 Gene

    Size:
    646 amino acids
    Molecular mass:
    71108 Da
    Quaternary structure:
    • Self-associates. May function as a homodimer (By similarity).
    Miscellaneous:
    • FATP1-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which is associated with disturbed fatty acid metabolism and homeostasis, such as obesity

    Alternative splice isoforms for SLC27A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC27A1 Gene

Proteomics data for SLC27A1 Gene at MOPED

Post-translational modifications for SLC27A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC27A1 Gene

Domains for SLC27A1 Gene

Gene Families for SLC27A1 Gene

HGNC:
  • ACS :Acyl-CoA synthetase family
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC27A1 Gene

Suggested Antigen Peptide Sequences for SLC27A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6PCB7

UniProtKB/Swiss-Prot:

S27A1_HUMAN :
  • Q6PCB7
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with SLC27A1: view

Function for SLC27A1 Gene

Molecular function for SLC27A1 Gene

UniProtKB/Swiss-Prot Function:
Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (By similarity).

Enzyme Numbers (IUBMB) for SLC27A1 Gene

Gene Ontology (GO) - Molecular Function for SLC27A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003824 catalytic activity --
GO:0004467 long-chain fatty acid-CoA ligase activity IEA --
GO:0015245 fatty acid transporter activity IEA --
GO:0031957 very long-chain fatty acid-CoA ligase activity IEA --
genes like me logo Genes that share ontologies with SLC27A1: view

Phenotypes for SLC27A1 Gene

genes like me logo Genes that share phenotypes with SLC27A1: view

Animal Models for SLC27A1 Gene

MGI Knock Outs for SLC27A1:

Animal Model Products

CRISPR Products

miRNA for SLC27A1 Gene

miRTarBase miRNAs that target SLC27A1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC27A1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for SLC27A1 Gene

Localization for SLC27A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC27A1 Gene

Cell membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane protein. Cytoplasm. Note=Plasma membrane and intracellular membranes, at least in adipocytes. Predominantly cytoplasmic in myocytes (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC27A1 Gene COMPARTMENTS Subcellular localization image for SLC27A1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
mitochondrion 2
extracellular 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC27A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC27A1: view

Pathways for SLC27A1 Gene

genes like me logo Genes that share pathways with SLC27A1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for SLC27A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001579 medium-chain fatty acid transport IEA --
GO:0001676 long-chain fatty acid metabolic process IEA --
GO:0006631 fatty acid metabolic process --
GO:0006646 phosphatidylethanolamine biosynthetic process IMP 19523918
GO:0006654 phosphatidic acid biosynthetic process IMP 19523918
genes like me logo Genes that share ontologies with SLC27A1: view

Compounds for SLC27A1 Gene

(40) HMDB Compounds for SLC27A1 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(14) Novoseek inferred chemical compound relationships for SLC27A1 Gene

Compound -log(P) Hits PubMed IDs
fatty acid 83.8 94
acyl-coa 74.9 12
triacylglycerol 60.9 1
lipid 49 11
rosiglitazone 47.9 2
genes like me logo Genes that share compounds with SLC27A1: view

Transcripts for SLC27A1 Gene

Unigene Clusters for SLC27A1 Gene

Solute carrier family 27 (fatty acid transporter), member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC27A1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC27A1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
SP1:
SP2:
SP3: - -
SP4: -
SP5: - -
SP6:
SP7:

Relevant External Links for SLC27A1 Gene

GeneLoc Exon Structure for
SLC27A1
ECgene alternative splicing isoforms for
SLC27A1

Expression for SLC27A1 Gene

mRNA expression in normal human tissues for SLC27A1 Gene

Protein differential expression in normal tissues for SLC27A1 Gene

This gene is overexpressed in Nasal epithelium (34.0) and Testis (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC27A1 Gene

SOURCE GeneReport for Unigene cluster for SLC27A1 Gene Hs.363138

mRNA Expression by UniProt/SwissProt for SLC27A1 Gene

Q6PCB7-S27A1_HUMAN
Tissue specificity: Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver.
genes like me logo Genes that share expressions with SLC27A1: view

Expression partners for SLC27A1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SLC27A1 Gene

Orthologs for SLC27A1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC27A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC27A1 35
  • 88.96 (n)
  • 92.57 (a)
SLC27A1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC27A1 35
  • 89.42 (n)
  • 92.72 (a)
SLC27A1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc27a1 35
  • 84.52 (n)
  • 89.47 (a)
Slc27a1 16
Slc27a1 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc27a1 35
  • 84.06 (n)
  • 89.63 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC27A1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC27A1 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC27A1 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC27A1 35
  • 71.93 (n)
  • 73.37 (a)
SLC27A1 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC27A1 36
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc27a1a 35
  • 64.81 (n)
  • 65.94 (a)
wufc10e12 35
slc27a1a 36
  • 66 (a)
OneToMany
slc27a1b 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG30194 36
  • 42 (a)
ManyToMany
CG3394 36
  • 38 (a)
ManyToMany
Fatp 36
  • 40 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea acs-20 36
  • 38 (a)
ManyToMany
acs-22 36
  • 40 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAT1 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9398 36
  • 42 (a)
OneToMany
Species with no ortholog for SLC27A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC27A1 Gene

ENSEMBL:
Gene Tree for SLC27A1 (if available)
TreeFam:
Gene Tree for SLC27A1 (if available)

Paralogs for SLC27A1 Gene

Paralogs for SLC27A1 Gene

Selected SIMAP similar genes for SLC27A1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC27A1: view

Variants for SLC27A1 Gene

Sequence variations from dbSNP and Humsavar for SLC27A1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs9137 -- 17,506,024(+) GCCTG(C/T)CCGTC utr-variant-3-prime
rs15401 -- 17,505,938(+) AGGAC(A/G)GCCCA utr-variant-3-prime
rs754847 -- 17,430,208(+) ATGAC(A/G)GGGCC intron-variant
rs890840 -- 17,430,373(-) TCCTC(A/G)GTAGC intron-variant
rs1023661 -- 17,412,957(-) cctta(A/G)gttta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC27A1 Gene

Variant ID Type Subtype PubMed ID
nsv911182 CNV Loss 21882294
nsv833768 CNV Loss 17160897
dgv3761n71 CNV Loss 21882294
nsv911203 CNV Loss 21882294
nsv911205 CNV Loss 21882294
dgv3762n71 CNV Loss 21882294
esv2677036 CNV Deletion 23128226

Relevant External Links for SLC27A1 Gene

HapMap Linkage Disequilibrium report
SLC27A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC27A1 Gene

Disorders for SLC27A1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SLC27A1 Gene in MalaCards »

(2) Diseases for SLC27A1 Gene including...

(3) Novoseek inferred disease relationships for SLC27A1 Gene

Disease -log(P) Hits PubMed IDs
insulin resistance 45.5 6
obesity 38.3 1
metabolic disorder 8.7 2

Relevant External Links for SLC27A1

Genetic Association Database (GAD)
SLC27A1
Human Genome Epidemiology (HuGE) Navigator
SLC27A1
genes like me logo Genes that share disorders with SLC27A1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for SLC27A1 Gene

Publications for SLC27A1 Gene

  1. The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression. (PMID: 10873384) Martin G. … Auwerx J. (Genomics 2000) 2 3 4 23
  2. Lack of association between certain candidate gene polymorphisms and the metabolic syndrome. (PMID: 15978856) Meirhaeghe A. … Dallongeville J. (Mol. Genet. Metab. 2005) 3 23 48
  3. A common polymorphism in the fatty acid transport protein-1 gene associated with elevated post-prandial lipaemia and alterations in LDL particle size distribution. (PMID: 12818409) Gertow K. … Fisher R.M. (Atherosclerosis 2003) 3 23 48
  4. FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down- regulates sphingomyelin and cholesterol metabolism in growing 293 cells. (PMID: 12235169) Hatch G.M. … Bernlohr D.A. (J. Lipid Res. 2002) 3 4 23
  5. FATP1 localizes to mitochondria and enhances pyruvate dehydrogenase activity in skeletal myotubes. (PMID: 19361580) Guitart M. … GarcA-a-MartA-nez C. (Mitochondrion 2009) 3 23

Products for SLC27A1 Gene

Sources for SLC27A1 Gene

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