Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SLC27A1 Gene

protein-coding   GIFtS: 59
GCID: GC19P017579

Solute Carrier Family 27 (Fatty Acid Transporter), Member...

  See SLC27A1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Solute Carrier Family 27 (Fatty Acid Transporter), Member 11 2     FATP-12 3
FATP12 3 5     FATP2 5
Fatty Acid Transport Protein 12 3     Long-Chain Fatty Acid Transport Protein 12
Solute Carrier Family 27 Member 12 3     EC 6.2.1.-3
ACSVL52 3     EC 6.2.18

External Ids:    HGNC: 109951   Entrez Gene: 3764972   Ensembl: ENSG000001303047   OMIM: 6006915   UniProtKB: Q6PCB73   

Export aliases for SLC27A1 gene to outside databases

Previous GC identifers: GC19U990163 GC19P017442 GC19P017146


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SLC27A1 Gene:
SLC27A1 (solute carrier family 27 (fatty acid transporter), member 1) is a protein-coding gene. Diseases associated with SLC27A1 include ichthyosis prematurity syndrome, and wrinkles. GO annotations related to this gene include very long-chain fatty acid-CoA ligase activity and protein homodimerization activity. An important paralog of this gene is SLC27A5.

UniProtKB/Swiss-Prot: S27A1_HUMAN, Q6PCB7
Function: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import
appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a
rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA
uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated
multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating
available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or
triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for
long-chain and very-long-chain fatty acids (By similarity)

Gene Wiki entry for SLC27A1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC27A1 gene promoter:
         Sp1   MyoD   RORalpha2   Egr-2   PPAR-gamma1   c-Myb   FOXO1a   PPAR-gamma2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC27A1 promoter sequence
   Search Chromatin IP Primers for SLC27A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC27A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

SLC27A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC27A1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P017579:  view genomic region     (about GC identifiers)

Start:
17,579,578 bp from pter      End:
17,616,977 bp from pter
Size:
37,400 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: S27A1_HUMAN, Q6PCB7 (See protein sequence)
Recommended Name: Long-chain fatty acid transport protein 1  
Size: 646 amino acids; 71108 Da
Subunit: Self-associates. May function as a homodimer (By similarity)
Miscellaneous: FATP1-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which
is associated with disturbed fatty acid metabolism and homeostasis, such as obesity
Secondary accessions: A6NIH2

Explore the universe of human proteins at neXtProt for SLC27A1: NX_Q6PCB7

Explore proteomics data for SLC27A1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SLC27A1 (Q6PCB7) (see all 10)
     VHSRYYR  EFVGLWLG  DPLRRFDGY  GENVSTTEVE 


    See SLC27A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_940982.1  
    ENSEMBL proteins: 
     ENSP00000472082   ENSP00000252595   ENSP00000472313   ENSP00000469459   ENSP00000469881  
     ENSP00000470457   ENSP00000413424  
    Reactome Protein details: Q6PCB7

    SLC27A1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SLC27A1
    GenScript Custom Purified and Recombinant Proteins Services for SLC27A1
    Novus Biologicals SLC27A1 Proteins
    Novus Biologicals SLC27A1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SLC27A1 

     
    antibodies-online proteins for SLC27A1 (4 products) 

     
    antibodies-online peptides for SLC27A1

    SLC27A1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SLC27A1 (FATP1)
    OriGene Antibodies for SLC27A1
    OriGene Custom Antibody Services for SLC27A1
    Novus Biologicals SLC27A1 Antibodies
    Abcam antibodies for SLC27A1
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for SLC27A1
    antibodies-online antibodies for SLC27A1 (18 products) 

    SLC27A1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC27A1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC27A1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SLC27A1 
    antibodies-online kits for SLC27A1 (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SLC: Solute carriers
    ACS: Acyl-CoA synthetase family

    IUPHAR Guide to PHARMACOLOGY protein family classification: Fatty acid transport protein 1
    SLC27 family of fatty acid transporters

    3 InterPro protein domains:
     IPR025110 AMP-bd_C
     IPR020845 AMP-binding_CS
     IPR000873 AMP-dep_Synth/Lig

    Graphical View of Domain Structure for InterPro Entry Q6PCB7

    ProtoNet protein and cluster: Q6PCB7

    1 Blocks protein domain: IPB000873 AMP-binding signature

    UniProtKB/Swiss-Prot: S27A1_HUMAN, Q6PCB7
    Similarity: Belongs to the ATP-dependent AMP-binding enzyme family


    Find genes that share domains with SLC27A1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S27A1_HUMAN, Q6PCB7
    Function: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import
    appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a
    rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA
    uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated
    multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating
    available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or
    triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for
    long-chain and very-long-chain fatty acids (By similarity)

         Enzyme Numbers (IUBMB): EC 6.2.12 EC 6.2.1.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003824catalytic activity ----
    GO:0015245fatty acid transporter activity IEA--
    GO:0031957very long-chain fatty acid-CoA ligase activity IEA--
    GO:0042803protein homodimerization activity IEA--
         
    Find genes that share ontologies with SLC27A1           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc27a1):
     homeostasis/metabolism  muscle 

    Find genes that share phenotypes with SLC27A1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Slc27a1tm1Jkk for SLC27A1

       genOway: Develop your customized and physiologically relevant rodent model for SLC27A1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLC27A1:
    hsa-mir-30d-5p (MIRT047803), hsa-mir-335-5p (MIRT017877)

    Block miRNA regulation of human, mouse, rat SLC27A1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate SLC27A1:
    hsa-miR-3910 hsa-miR-124 hsa-miR-506 hsa-miR-145 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidSLC27A1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC27A1
    Predesigned siRNA for gene silencing in human, mouse, rat SLC27A1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC27A1

    Clone
    Products:
         
    OriGene clones in human, mouse for SLC27A1 (see all 6)
    OriGene ORF clones in mouse, rat for SLC27A1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC27A1 (NM_198580)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC27A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC27A1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC27A1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLC27A1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC27A1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    S27A1_HUMAN, Q6PCB7: Cell membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane
    protein. Cytoplasm (By similarity). Note=Plasma membrane and intracellular membranes, at least in adipocytes.
    Predominantly cytoplasmic in myocytes (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum2
    mitochondrion2
    extracellular1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005886plasma membrane TAS--
    GO:0012505endomembrane system ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLC27A1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SLC27A1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transmembrane transport of small molecules0.47
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    4Transport of vitamins, nucleosides, and related molecules
    Transport of vitamins, nucleosides, and related molecules
    Transport of fatty acids0.00
    5PPAR signaling pathway
    PPAR signaling pathway


    Find genes that share SuperPaths with SLC27A1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for SLC27A1
        PPARA activates gene expression
    Transport of fatty acids

    1 PharmGKB Pathway for SLC27A1
        Metformin Pathway, Pharmacokinetics

    1 Kegg Pathway  (Kegg details for SLC27A1):
        PPAR signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC27A1: 
              Fatty Acid Metabolism in human mouse rat
              Insulin Resistance in human mouse rat
              PPAR Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLC27A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SLC27A1 (Q6PCB73 ENSP000002525954) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPE65Q165183, ENSP000002623404I2D: score=1 STRING: ENSP00000262340
    BECN1Q144573I2D: score=1 
    CHD9ENSP000003815224STRING: ENSP00000381522
    NCOA6ENSP000003518944STRING: ENSP00000351894
    PPARAENSP000002627354STRING: ENSP00000262735
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001579medium-chain fatty acid transport IEA--
    GO:0006631fatty acid metabolic process IEA--
    GO:0006646phosphatidylethanolamine biosynthetic process IMP19523918
    GO:0006654phosphatidic acid biosynthetic process IMP19523918
    GO:0006655phosphatidylglycerol biosynthetic process IMP19523918

    Find genes that share ontologies with SLC27A1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC27A1 (S27A1)

    Selected HMDB Compounds for SLC27A1 (see all 40)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--

    Selected Novoseek inferred chemical compound relationships for SLC27A1 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty acid 83.8 164 17130465 (4), 19560442 (3), 15897321 (3), 16357361 (3) (see all 72)
    acyl-coa 74.9 13 15294040 (2), 11724471 (2), 14749206 (1), 19535819 (1) (see all 10)
    triacylglycerol 60.9 1 15525872 (1)
    lipid 49 19 12818409 (2), 15767857 (1), 16788709 (1), 15294040 (1) (see all 10)
    rosiglitazone 47.9 4 17463056 (1), 10548525 (1)
    palmitate 39.9 5 15897321 (5)
    sterol 37.3 1 14749206 (1)
    oleic acid 36.6 6 15897321 (6)
    docosahexaenoic acid 33.4 1 18639956 (1)
    phospholipid 29.3 1 19523918 (1)



    Find genes that share compounds with SLC27A1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SLC27A1 gene: 
    NM_198580.1  

    Unigene Cluster for SLC27A1:

    Solute carrier family 27 (fatty acid transporter), member 1
    Hs.363138  [show with all ESTs]
    Unigene Representative Sequence: AK131101
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000600277 ENST00000252595(uc002ngt.1 uc002ngu.1 uc010xpp.1 uc002ngv.1)
    ENST00000598424 ENST00000599380 ENST00000600297 ENST00000593701 ENST00000594962
    ENST00000598848 ENST00000599965 ENST00000442725
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC27A1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate SLC27A1:
    hsa-miR-3910 hsa-miR-124 hsa-miR-506 hsa-miR-145 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidSLC27A1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLC27A1
    Predesigned siRNA for gene silencing in human, mouse, rat SLC27A1
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC27A1 (see all 6)
    OriGene ORF clones in mouse, rat for SLC27A1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC27A1 (NM_198580)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC27A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC27A1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLC27A1
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC27A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC27A1
      QuantiTect SYBR Green Assays in human, mouse, rat SLC27A1
      QuantiFast Probe-based Assays in human, mouse, rat SLC27A1

    Additional mRNA sequence: 

    AK125289.1 AK131101.1 AK294238.1 AK296355.1 AK299852.1 AK315935.1 BC013149.1 BC059399.1 

    14 DOTS entries:

    DT.100740329  DT.100665893  DT.91798085  DT.428856  DT.101978022  DT.95155977  DT.95365597  DT.91747806 
    DT.100672981  DT.75146738  DT.99931620  DT.99996731  DT.99999022  DT.95321144 

    Selected AceView cDNA sequences (see all 103):

    BF058556 AI073915 BI766707 CB241510 BG055011 BM741597 AI357607 AI360113 
    BC059399 AI124693 BQ712480 AW194786 NM_198580 AI497962 BI488690 AK131101 
    AW117402 CB216429 AI805842 BG828409 BC013149 BQ774519 BE386391 AW014467 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC27A1 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
    SP1:                                                                                                                              
    SP2:                                                                                                                              
    SP3:                                      -                 -                                                                     
    SP4:                                                        -                                                                     
    SP5:        -           -                                                                                                         


    ECgene alternative splicing isoforms for SLC27A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SLC27A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAACTTTCC
    SLC27A1 Expression
    About this image


    SLC27A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    SLC27A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC27A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.363138

    UniProtKB/Swiss-Prot: S27A1_HUMAN, Q6PCB7
    Tissue specificity: Highest levels of expression are detected in muscle and adipose tissue small, intermediate
    levels in small intestine, and barely detectable in liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC27A1: 
              Fatty Acid Metabolism in human mouse rat
              Insulin Resistance in human mouse rat
              PPAR Targets in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLC27A1
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC27A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC27A1
    QuantiTect SYBR Green Assays in human, mouse, rat SLC27A1
    QuantiFast Probe-based Assays in human, mouse, rat SLC27A1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC27A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC27A1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc27a11 , 5 solute carrier family 27 (fatty acid transporter), more1, 5 84.52(n)1
    89.47(a)1
      8 (34.43 cM)5
    264571  NM_011977.31  NP_036107.11 
     715689275 
    chicken
    (Gallus gallus)
    Aves SLC27A11 solute carrier family 27 (fatty acid transporter), more 71.93(n)
    73.37(a)
      426008  NM_001039602.1  NP_001034691.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC27A16
    solute carrier family 27 (fatty acid transporter),...
    71(a)
    1 ↔ 1
    GL343198.1(3819467-3861198)
    zebrafish
    (Danio rerio)
    Actinopterygii wufc10e122 Transcribed sequence with weak similarity to protein more 78.55(n)    BI428474.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG301946
    Fatp6
    (see all 3)
    Fatty acid (long chain) transport protein
    (see all 3)
    42(a)
    40(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2R(18943019-18949074)
    2L(10511252-10517216)
    worm
    (Caenorhabditis elegans)
    Secernentea acs-226
    acs-206
    Protein ACS-20 (acs-20) mRNA, complete cds
    40(a)
    38(a)
    many ↔ many
    many ↔ many
    X(8931241-8939261) WBGene00017012
    IV(12392123-12398706) WBGene00009218
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FAT16
    Very long chain fatty acyl-CoA synthetase and long...
    28(a)
    1 → many
    II(318266-320275) YBR041W


    ENSEMBL Gene Tree for SLC27A1 (if available)
    TreeFam Gene Tree for SLC27A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SLC27A1 gene
    SLC27A52  SLC27A22  SLC27A42  SLC27A32  SLC27A62  
    6 SIMAP similar genes for SLC27A1 using alignment to 6 protein entries:     S27A1_HUMAN (see all proteins):
    FLJ00336    SLC27A4    SLC27A3    SLC27A2    SLC27A6    SLC27A5

    Find genes that share paralogs with SLC27A1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SLC27A1 (see all 888)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1832963471,2
    --17579438(+) GGCCTC/GTCCTC 1 -- us2k10--------
    rs1878807231,2
    --17579517(+) GTGAGA/TGCCTG 1 -- us2k10--------
    rs602836061,2
    C,F--17579581(+) AGAACG/TCTGGA 1 -- us2k12Minor allele frequency- T:0.16WA 120
    rs1434846081,2
    --17579778(+) TCCTGC/TCTGAG 1 -- us2k10--------
    rs1471621751,2
    C--17579948(+) GCGTGC/TGGATT 1 -- us2k10--------
    rs81093731,2
    C,F,A,H--17579984(+) TGACGG/TTGAGA 1 -- us2k1 tfbs330Minor allele frequency- T:0.14EA NA NS WA CSA 2983
    rs1910785461,2
    --17580090(+) CTGAGA/GCCCCA 1 -- us2k10--------
    rs621267751,2
    C,F--17580168(+) TTGGAC/TTTAGG 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs81108301,2
    C,A,H--17580183(+) GCTGGG/AGCAAG 1 -- us2k113Minor allele frequency- A:0.29NA WA CSA EA 376
    rs81137071,2
    C,F,A,H--17580226(+) GGGATT/ATTTTT 1 -- us2k113Minor allele frequency- A:0.21NS NA WA CSA EA 673

    HapMap Linkage Disequilibrium report for SLC27A1 (17579578 - 17616977 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SLC27A1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677036CNV Deletion23128226
    nsv911182CNV Loss21882294
    dgv3761n71CNV Loss21882294
    dgv3762n71CNV Loss21882294
    nsv911205CNV Loss21882294
    nsv833768CNV Loss17160897
    nsv911203CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC27A1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC27A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600691    OMIM disorders: --

    3 diseases for SLC27A1:    
    About MalaCards
    ichthyosis prematurity syndrome    wrinkles    insulin resistance


    Find genes that share disorders with SLC27A1           About GenesLikeMe

    3 Novoseek inferred disease relationships for SLC27A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin resistance 45.5 6 15767857 (4), 15168018 (1), 14715877 (1)
    obesity 38.3 1 15168018 (1)
    metabolic disorder 8.7 2 10873384 (1), 11970897 (1)

    Genetic Association Database (GAD): SLC27A1
    Human Genome Epidemiology (HuGE) Navigator: SLC27A1 (9 documents)

    Export disorders for SLC27A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SLC27A1 gene, integrated from 10 sources (see all 95):
    (articles sorted by number of sources associating them with SLC27A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression. (PubMed id 10873384)1, 2, 3, 9 Martin G.... Auwerx J. (Genomics 2000)
    2. A common polymorphism in the fatty acid transport protein-1 gene associated with elevated post-prandial lipaemia and alterations in LDL particle size distribution. (PubMed id 12818409)1, 4, 9 Gertow K....Fisher R.M. (Atherosclerosis 2003)
    3. Lack of association between certain candidate gene polymorphisms and the metabolic syndrome. (PubMed id 15978856)1, 4, 9 Meirhaeghe A....Dallongeville J. (Mol. Genet. Metab. 2005)
    4. FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down- regulates sphingomyelin and cholesterol metabolism in growing 293 cells. (PubMed id 12235169)1, 2, 9 Hatch G.M.... Bernlohr D.A. (J. Lipid Res. 2002)
    5. Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. (PubMed id 20360315)1, 4 Uher R....McGuffin P. (Am J Psychiatry 2010)
    6. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (BMC Genet. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells. (PubMed id 15897321)1, 9 GarcA-a-MartA-nez C....GA^mez-Foix A.M. (Am. J. Physiol., Cell Physiol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 376497 HGNC: 10995 AceView: SLC27A1 Ensembl:ENSG00000130304 euGenes: HUgn376497
    ECgene: SLC27A1 Kegg: 376497 H-InvDB: SLC27A1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SLC27A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SLC27A1 gene:
    Search GeneIP for patents involving SLC27A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for SLC27A1 (FATP1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for SLC27A1 (FATP1)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SLC27A1   OriGene RNAi products in human, mouse, rat for SLC27A1  
     OriGene qPCR primer pairs and template standards for SLC27A1   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC27A1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC27A1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC27A1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC27A1   OriGene Custom Protein Services for SLC27A1  

     
     
     Block miRNA regulation of human, mouse, rat SLC27A1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLC27A1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC27A1 Predesigned siRNA for gene silencing in human, mouse, rat SLC27A1
     QuantiFast Probe-based Assays in human, mouse, rat SLC27A1 QuantiTect SYBR Green Assays in human, mouse, rat SLC27A1
     PCR Arrays including human, mouse, rat SLC27A1 Search Chromatin IP Primers for SLC27A1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC27A1  GeneGlobe Interaction Network for SLC27A1
     Regulatory tfbs in SLC27A1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SLC27A1 GenScript cDNA clones with any tag delivered in your preferred vector for SLC27A1
     GenScript Custom Assay Services for SLC27A1 GenScript Custom overexpressing Cell Line Services for SLC27A1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SLC27A1 (S27A1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SLC27A1 antibodies
     SLC27A1 proteins
     SLC27A1 lysates
     Antibodies for SLC27A1
     See all of Abcam's Antibodies, Kits and Proteins for SLC27A1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SLC27A1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC27A1
     SwitchGear 3'UTR luciferase reporter plasmids for SLC27A1
     SwitchGear Promoter luciferase reporter plasmids for SLC27A1
     Search ThermoFisher Antibodies for SLC27A1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC27A1
     Browse compounds at ApexBio
     Search Addgene for plasmids for SLC27A1
      Search eBioscience for proteins for SLC27A1
      Search eBioscience for elisas for SLC27A1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for SLC27A1
     antibodies-online antibodies for SLC27A1 (18 products)
     antibodies-online kits for SLC27A1 (9 products)
     antibodies-online peptides for SLC27A1
     antibodies-online proteins for SLC27A1 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC27A1 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4