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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC27A1 Gene

protein-coding GIFtS: 57
GCID: GC19P017579

solute carrier family 27 (fatty acid transporter), member...

Explore 14 diseases affiliated with
SLC27A1 via

MalaCards

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 27 (Fatty Acid Transporter), Member 1¹ ²		FATP-1² ³
FATP1¹ ² ³ ⁵		FLJ00336¹
ACSVL5¹ ² ³		MGC71751¹
FATP¹ ² ⁵		Long-Chain Fatty Acid Transport Protein 1²
Fatty Acid Transport Protein 1² ³		EC 6.2.1.-³
Solute Carrier Family 27 Member 1² ³		EC 6.2.1⁸

External Ids:	HGNC: 10995¹	Entrez Gene: 376497²	Ensembl: ENSG00000130304⁷	OMIM: 600691⁵	UniProtKB: Q6PCB7³

Export aliases for SLC27A1 gene to outside databases

Previous GC identifers: GC19U990163 GC19P017442 GC19P017146

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: S27A1_HUMAN, Q6PCB7

Function: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import

appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid

translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake.

May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric

protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA

substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May

be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain

fatty acids (By similarity)

Gene Wiki entry for SLC27A1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC27A1 gene promoter:
Sp1 MyoD RORalpha2 Egr-2 PPAR-gamma1 c-Myb FOXO1a PPAR-gamma2 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC27A1 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC27A1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC27A1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.1

SLC27A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC27A1 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P017579: view genomic region (about GC identifiers)

Start:	17,579,578 bp from pter	End:	17,616,977 bp from pter
Size:	37,400 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S27A1_HUMAN, Q6PCB7 (See protein sequence)

Recommended Name: Long-chain fatty acid transport protein 1

Size: 646 amino acids; 71108 Da

Subunit: Self-associates. May function as a homodimer (By similarity)

Subcellular location: Cell membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane protein.

Cytoplasm (By similarity). Note=Plasma membrane and intracellular membranes, at least in adipocytes. Predominantly

cytoplasmic in myocytes (By similarity)

Miscellaneous: FATP1-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which is

associated with disturbed fatty acid metabolism and homeostasis, such as obesity

Secondary accessions: A6NIH2

Explore the universe of human proteins at neXtProt for SLC27A1: NX_Q6PCB7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6PCB7

4/10 DME Specific Peptides for SLC27A1 (Q6PCB7) (see all 10)

VHSRYYR

EFVGLWLG

DPLRRFDGY

GENVSTTEVE

SLC27A1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_940982.1

ENSEMBL proteins:

ENSP00000413424 ENSP00000252595

Reactome Protein details: Q6PCB7
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SLC27A1

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	--	--
GO:0005743	mitochondrial inner membrane	--	--
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005792	microsome	--	--
GO:0005886	plasma membrane	TAS	--

SLC27A1 for ontologies About GeneDecksing

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Assay Products for SLC27A1:

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	Uscn ELISAs and CLIAs for SLC27A1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC27A1 for domains About GeneDecksing

2 InterPro domains/families:

IPR000873 AMP-dep_Synth/Lig

IPR020845 AMP-binding_CS

Graphical View of Domain Structure for InterPro Entry Q6PCB7

ProtoNet protein and cluster: Q6PCB7

1 Blocks protein family: IPB000873 AMP-binding signature

UniProtKB/Swiss-Prot: S27A1_HUMAN, Q6PCB7

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: S27A1_HUMAN, Q6PCB7

Function: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import

appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid

translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake.

May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric

protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA

substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May

be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain

fatty acids (By similarity)

Enzyme Numbers (IUBMB): EC 6.2.1² EC 6.2.1.-¹

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC27A1

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005515	protein binding	--	--
GO:0015245	fatty acid transporter activity	IEA	--
GO:0031957	very long-chain fatty acid-CoA ligase activity	IEA	--
GO:0042803	protein homodimerization activity	IEA	--

SLC27A1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Slc27a1^tm1Jkk for SLC27A1
     2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slc27a1):

homeostasis/metabolism

muscle

SLC27A1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	1.00			Fatty acid, triacylglycerol, and ketone body metabolism	0.52
	PPARA Activates Gene Expression	0.74

SLC-mediated transmembrane transport

SLC-mediated transmembrane transport

1.00

Transmembrane transport of small molecules

0.50

Metabolism

Metabolism

1.00

Metabolism of lipids and lipoproteins

0.34

Expression of FATP1 (SLC27A1)

Expression of FATP1 (SLC27A1)

1.00

Transport of fatty acids

0.33

PPAR signaling pathway

PPAR signaling pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/10 Reactome Pathways for SLC27A1 (see all 10)

	Metabolism
	Transport of fatty acids
	Expression of FATP1 (SLC27A1)
	Fatty acid, triacylglycerol, and ketone body metabolism
	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

1 PharmGKB Pathway for SLC27A1

Metformin Pathway, Pharmacokinetics

1 Kegg Pathway (Kegg details for SLC27A1):

PPAR signaling pathway

SLC27A1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SLC27A1

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/14 Interacting proteins for SLC27A1 (Q6PCB7³ ENSP00000252595⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RPE65	Q16518³, ENSP00000262340⁴	I2D: score=1 STRING: ENSP00000262340
BECN1	Q14457³	I2D: score=1
CHD9	ENSP00000381522⁴	STRING: ENSP00000381522
NCOA6	ENSP00000351894⁴	STRING: ENSP00000351894
PPARA	ENSP00000262735⁴	STRING: ENSP00000262735

About this table

Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001579	medium-chain fatty acid transport	IEA	--
GO:0006631	fatty acid metabolic process	IEA	--
GO:0006646	phosphatidylethanolamine biosynthetic process	IMP	19523918
GO:0006654	phosphatidic acid biosynthetic process	IMP	19523918
GO:0006655	phosphatidylglycerol biosynthetic process	IMP	19523918

SLC27A1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SLC27A1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC27A1

10/40 HMDB Compounds for SLC27A1 (see all 40) About this table

Compound	Synonyms	CAS #	PubMed Ids
(2E)-Decenoyl-CoA	(E)-S-2-decenoate Coenzyme A (see all 15)	10018-95-8	--
(2E)-Dodecenoyl-CoA	2-trans-Dodecenoyl-Coenzyme A (see all 4)	1066-12-2	--
(2E)-Hexadecenoyl-CoA	trans-2-Hexadecenoyl-CoA (see all 4)	4460-95-1	--
(2E)-Octenoyl-CoA	(E)-S-2-octenoate Coenzyme A (see all 16)	10018-94-7	--
(2E)-Tetradecenoyl-CoA	(2E)-Tetradecenoyl-Coenzyme A (see all 8)	38795-33-4	--
2-Methylbutyryl-CoA	2-methylbutanoyl-CoA (see all 11)	6712-02-3	--
2-Methylhexanoyl-CoA	2-Methylhexanoyl-CoEnzyme A (see all 5)	--	--
3Z-dodecenoyl-CoA	S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)	2152-91-2	--
Acetyl-CoA	S-Acetyl coenzyme A (see all 13)	72-89-9	--
Acrylyl-CoA	Acryloyl coenzyme A (see all 14)	5776-58-9	--

10/14 Novoseek chemical compound relationships for SLC27A1 gene (see all 14) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fatty acid	83.8	164	17130465 (4), 19560442 (3), 15897321 (3), 16357361 (3) (see all 72)
acyl-coa	74.9	13	15294040 (2), 11724471 (2), 14749206 (1), 19535819 (1) (see all 10)
triacylglycerol	60.9	1	15525872 (1)
lipid	49	19	12818409 (2), 15767857 (1), 16788709 (1), 15294040 (1) (see all 10)
rosiglitazone	47.9	4	17463056 (1), 10548525 (1)
palmitate	39.9	5	15897321 (5)
sterol	37.3	1	14749206 (1)
oleic acid	36.6	6	15897321 (6)
docosahexaenoic acid	33.4	1	18639956 (1)
phospholipid	29.3	1	19523918 (1)

Search CenterWatch for drugs/clinical trials and news about SLC27A1 / S27A1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC27A1 gene:

NM_198580.1

Unigene Cluster for SLC27A1:

Solute carrier family 27 (fatty acid transporter), member 1

Hs.363138 [show with all ESTs]

Unigene Representative Sequence: AK131101

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000442725 ENST00000252595(uc002ngt.1 uc002ngu.1 uc010xpp.1 uc002ngv.1)

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC27A1

Additional cDNA sequence:

AK125289.1 AK131101.1 AK294238.1 AK296355.1 AK299852.1 AK315935.1 BC013149.1 BC059399.1

14 DOTS entries:

DT.100740329 DT.100665893 DT.91798085 DT.428856 DT.101978022 DT.95155977 DT.95365597 DT.91747806

DT.100672981 DT.75146738 DT.99931620 DT.99996731 DT.99999022 DT.95321144

24/103 AceView cDNA sequences (see all 103):

BQ712480 BI766707 CB241510 AI124693 AI497962 AI357607 BC059399 AI073915

AI360113 NM_198580 BF058556 BG055011 BI488690 BM741597 AW194786 AI815385

AI347907 AI364815 CD300103 AI805842 BX099013 BG325287 BQ879802 BM807946

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SLC27A1 (see all 7) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15
SP1:
SP2:
SP3:													-						-
SP4:																			-
SP5:			-				-

ECgene alternative splicing isoforms for SLC27A1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC27A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAACTTTCC

About this image

SLC27A1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

8 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Choroid Plexus

Mature Choroid Plexus Cells

Selective marker (cell-identifying gene)

Choroid Plexus

Brain

Brain

Diencephalic Ventricular Zone

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Metencephalon

Neural Tube

Telencephalon

Neural Tube

Spinal Cord

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLC27A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC27A1

SOURCE GeneReport for Unigene cluster: Hs.363138

UniProtKB/Swiss-Prot: S27A1_HUMAN, Q6PCB7

Tissue specificity: Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels

in small intestine, and barely detectable in liver

SABiosciences Expression via Pathway-Focused PCR Arrays including SLC27A1:

Fatty Acid Metabolism in human mouse rat

Insulin Resistance in human mouse rat

PPAR Targets in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC27A1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SLC27A1 gene from 5/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLC27A1¹	solute carrier family 27 (fatty acid transporter), more	71.93(n) 73.37(a)		426008 NM_001039602.1 NP_001034691.1
lizard (Anolis carolinensis)	Reptilia	SLC27A1⁶	--	71(a)	1 ↔ 1	GL343198.1(3823042-3849173)
zebrafish (Danio rerio)	Actinopterygii	wufc10e12²	Transcribed sequence with weak similarity to protein more	78.55(n)		BI428474.1
fruit fly (Drosophila melanogaster)	Insecta	CG30194⁶ Fatp⁶ (see all 3)	Fatty acid (long chain) transport protein (see all 3)	41(a) 40(a) (see all 3)	many ↔ many many ↔ many (see all 3)	2R(18943019-18949074) 2L(10511252-10517216)
worm (Caenorhabditis elegans)	Secernentea	acs-22⁶ acs-20⁶	Protein ACS-20	40(a) 38(a)	many ↔ many many ↔ many	X(8931187-8939207) IV(12392099-12398682)

ENSEMBL Gene Tree for SLC27A1 (if available)
TreeFam Gene Tree for SLC27A1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for SLC27A1 gene

SLC27A5² SLC27A2² SLC27A4² SLC27A3² SLC27A6²

6 SIMAP similar genes for SLC27A1 using alignment to 6 protein entries: S27A1_HUMAN (see all proteins):

FLJ00336 SLC27A4 SLC27A3 SLC27A2 SLC27A6 SLC27A5

SLC27A1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183296347^1,2		--	17579438(+)	`GGCCTC/GTCCTC`	1	--	us2k¹		0	--	--	--	--
rs187880723^1,2		--	17579517(+)	`GTGAGA/TGCCTG`	1	--	us2k¹		0	--	--	--	--
rs60283606^1,2	C,	--	17579581(+)	`AGAACG/TCTGGA`	1	--	us2k¹		2		WA	120
rs143484608^1,2		--	17579778(+)	`TCCTGC/TCTGAG`	1	--	us2k¹		0	--	--	--	--
rs147162175^1,2		--	17579948(+)	`GCGTGC/TGGATT`	1	--	us2k¹		0	--	--	--	--
rs8109373^1,2	C,F,A,H,	--	17579984(+)	`TGACGG/TTGAGA`	1	--	us2k¹ tfbs³		30		EA NA NS WA CSA	2983
rs191078546^1,2		--	17580090(+)	`CTGAGA/GCCCCA`	1	--	us2k¹		0	--	--	--	--
rs62126775^1,2		--	17580168(+)	`TTGGAC/TTTAGG`	1	--	us2k¹		1		NA	2
rs8110830^1,2	C,A,H,	--	17580183(+)	`GCTGGG/AGCAAG`	1	--	us2k¹		13		NA WA CSA EA	376
rs8113707^1,2	C,F,A,H,	--	17580226(+)	`GGGATT/ATTTTT`	1	--	us2k¹		13		NS NA WA CSA EA	673

HapMap Linkage Disequilibrium report for SLC27A1 (17579578 - 17616977 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC27A1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC27A1

DNA2.0 Custom Variant and Variant Library Synthesis for SLC27A1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SLC27A1 for disorders           About GeneDecksing

OMIM gene information: 600691    OMIM disorders: --

14 diseases for SLC27A1:    About MalaCards

ichthyosis prematurity syndrome insulin resistance metabolic disorders ichthyosis

dilated cardiomyopathy lipodystrophy cardiomyopathy obesity

prostate cancer cholesterol prostatitis tuberculosis

neuronitis mycobacterium tuberculosis

3 Novoseek disease relationships for SLC27A1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
insulin resistance	45.5	6	15767857 (4), 15168018 (1), 14715877 (1)
obesity	38.3	1	15168018 (1)
metabolic disorder	8.7	2	10873384 (1), 11970897 (1)

Genetic Association Database (GAD): SLC27A1
Human Genome Epidemiology (HuGE) Navigator: SLC27A1 (9 documents)

Export disorders for SLC27A1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SLC27A1 gene, integrated from 9 sources (see all 96):
(articles sorted by number of sources associating them with SLC27A1)

Utopia: connect your pdf to the dynamic
world of online information

The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression. (PubMed id 10873384)^{1, 2, 3, 9} Martin G.... Auwerx J. (2000)
A common polymorphism in the fatty acid transport protein-1 gene associated with elevated post-prandial lipaemia and alterations in LDL particle size distribution. (PubMed id 12818409)^{1, 4, 9} Gertow K....Fisher R.M. (2003)
Lack of association between certain candidate gene polymorphisms and the metabolic syndrome. (PubMed id 15978856)^{1, 4, 9} Meirhaeghe A....Dallongeville J. (2005)
FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down- regulates sphingomyelin and cholesterol metabolism in growing 293 cells. (PubMed id 12235169)^{1, 2, 9} Hatch G.M.... Bernlohr D.A. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells. (PubMed id 15897321)^{1, 9} Garcia-Martinez C....Gomez-Foix A.M. (2005)
FATP1 localizes to mitochondria and enhances pyruvate dehydrogenase activity in skeletal myotubes. (PubMed id 19361580)^{1, 9} Guitart M....GarcA-a-MartA-nez C. (2009)
FATP1 inhibits 11-cis retinol formation via interacti on with the visual cycle retinoid isomerase RPE65 and lecithin:retinol acyltran sferase. (PubMed id 20356843)^{1, 9} Guignard T.J....Brabet P. (2010)
Regulation of cardiolipin biosynthesis by fatty acid transport protein-1 IN HEK 293 cells. (PubMed id 19523918)^{1, 9} Mitchell R.W. and Hatch G.M. (2009)
Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. (PubMed id 7954810)^{1, 9} Schaffer J.E. and Lodish H.F. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 376497	HGNC: 10995	AceView: SLC27A1	Ensembl:ENSG00000130304	euGenes: HUgn376497
ECgene: SLC27A1	Kegg: 376497	H-InvDB: SLC27A1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SLC27A1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC27A1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SLC27A1 gene:
Search GeneIP for patents involving SLC27A1

GeneCards and IP:
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