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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC27A1 Gene

protein-coding   GIFtS: 59
GCID: GC19P017579

Solute Carrier Family 27 (Fatty Acid Transporter), Member...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 27 (Fatty Acid Transporter), Member 11 2     FATP-12 3
FATP12 3 5     FATP2 5
Fatty Acid Transport Protein 12 3     Long-Chain Fatty Acid Transport Protein 12
Solute Carrier Family 27 Member 12 3     EC 6.2.1.-3
ACSVL52 3     EC 6.2.18

External Ids:    HGNC: 109951   Entrez Gene: 3764972   Ensembl: ENSG000001303047   OMIM: 6006915   UniProtKB: Q6PCB73   

Export aliases for SLC27A1 gene to outside databases

Previous GC identifers: GC19U990163 GC19P017442 GC19P017146


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC27A1 Gene: 
SLC27A1 (solute carrier family 27 (fatty acid transporter), member 1) is a protein-coding gene. Diseases associated with SLC27A1 include ichthyosis prematurity syndrome, and ichthyosis, and among its related super-pathways are Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Transmembrane transport of small molecules. GO annotations related to this gene include very long-chain fatty acid-CoA ligase activity and protein homodimerization activity. An important paralog of this gene is SLC27A5.

UniProtKB/Swiss-Prot: S27A1_HUMAN, Q6PCB7
Function: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import
appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a
rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA
uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated
multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating
available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or
triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for
long-chain and very-long-chain fatty acids (By similarity)

Gene Wiki entry for SLC27A1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC27A1 gene promoter:
         Sp1   MyoD   RORalpha2   Egr-2   PPAR-gamma1   c-Myb   FOXO1a   PPAR-gamma2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC27A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC27A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC27A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

SLC27A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC27A1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P017579:  view genomic region     (about GC identifiers)

Start:
17,579,578 bp from pter      End:
17,616,977 bp from pter
Size:
37,400 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S27A1_HUMAN, Q6PCB7 (See protein sequence)
Recommended Name: Long-chain fatty acid transport protein 1  
Size: 646 amino acids; 71108 Da
Subunit: Self-associates. May function as a homodimer (By similarity)
Subcellular location: Cell membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane
protein. Cytoplasm (By similarity). Note=Plasma membrane and intracellular membranes, at least in adipocytes.
Predominantly cytoplasmic in myocytes (By similarity)
Miscellaneous: FATP1-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which
is associated with disturbed fatty acid metabolism and homeostasis, such as obesity
Secondary accessions: A6NIH2

Explore the universe of human proteins at neXtProt for SLC27A1: NX_Q6PCB7

Explore proteomics data for SLC27A1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6PCB7

  • 4/10 DME Specific Peptides for SLC27A1 (Q6PCB7) (see all 10)
     VHSRYYR  EFVGLWLG  DPLRRFDGY  GENVSTTEVE 

    SLC27A1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC27A1 Protein Expression
    REFSEQ proteins: NP_940982.1  
    ENSEMBL proteins: 
     ENSP00000472082   ENSP00000252595   ENSP00000472313   ENSP00000469459   ENSP00000469881  
     ENSP00000470457   ENSP00000413424  
    Reactome Protein details: Q6PCB7
    Human Recombinant Protein Products for SLC27A1: 
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    Novus Biologicals SLC27A1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005886plasma membrane TAS--
    GO:0012505endomembrane system IEA--
    GO:0016021integral to membrane IEA--

    SLC27A1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers
    ACS: Acyl-CoA synthetase family

    IUPHAR Guide to PHARMACOLOGY protein family classification: Fatty acid transport protein 1 
    SLC27 family of fatty acid transporters

    2 InterPro protein domains:
     IPR000873 AMP-dep_Synth/Lig
     IPR020845 AMP-binding_CS

    Graphical View of Domain Structure for InterPro Entry Q6PCB7

    ProtoNet protein and cluster: Q6PCB7

    1 Blocks protein domain: IPB000873 AMP-binding signature

    UniProtKB/Swiss-Prot: S27A1_HUMAN, Q6PCB7
    Similarity: Belongs to the ATP-dependent AMP-binding enzyme family


    SLC27A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S27A1_HUMAN, Q6PCB7
    Function: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import
    appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a
    rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA
    uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated
    multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating
    available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or
    triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for
    long-chain and very-long-chain fatty acids (By similarity)

         Enzyme Numbers (IUBMB): EC 6.2.12 EC 6.2.1.-1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003824catalytic activity ----
    GO:0015245fatty acid transporter activity IEA--
    GO:0031957very long-chain fatty acid-CoA ligase activity IEA--
    GO:0042803protein homodimerization activity IEA--
         
    SLC27A1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc27a1):
     homeostasis/metabolism  muscle 

    SLC27A1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Slc27a1tm1Jkk for SLC27A1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC27A1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC27A1 
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    SwitchGear 3'UTR luciferase reporter plasmidSLC27A1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC27A1 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.74
    Fatty acid, triacylglycerol, and ketone body metabolism0.52
    PPARA Activates Gene Expression0.74
    2SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transmembrane transport of small molecules0.50
    3Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    4Transport of organic anions
    Transport of vitamins, nucleosides, and related molecules0.34
    5Abacavir transport and metabolism
    Metformin Pathway, Pharmacokinetics0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/9        Reactome Pathways for SLC27A1 (see all 9)
        Metabolism
    Transport of fatty acids
    Fatty acid, triacylglycerol, and ketone body metabolism
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    SLC-mediated transmembrane transport

    1 PharmGKB Pathway for SLC27A1
        Metformin Pathway, Pharmacokinetics

    1         Kegg Pathway  (Kegg details for SLC27A1):
        PPAR signaling pathway


    SLC27A1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC27A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/14 Interacting proteins for SLC27A1 (Q6PCB73 ENSP000002525954) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPE65Q165183, ENSP000002623404I2D: score=1 STRING: ENSP00000262340
    BECN1Q144573I2D: score=1 
    CHD9ENSP000003815224STRING: ENSP00000381522
    NCOA6ENSP000003518944STRING: ENSP00000351894
    PPARAENSP000002627354STRING: ENSP00000262735
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001579medium-chain fatty acid transport IEA--
    GO:0006631fatty acid metabolic process IEA--
    GO:0006646phosphatidylethanolamine biosynthetic process IMP19523918
    GO:0006654phosphatidic acid biosynthetic process IMP19523918
    GO:0006655phosphatidylglycerol biosynthetic process IMP19523918

    SLC27A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC27A1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SLC27A1 (S27A1)

    10/40 HMDB Compounds for SLC27A1 (see all 40)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--

    10/14 Novoseek inferred chemical compound relationships for SLC27A1 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty acid 83.8 164 17130465 (4), 19560442 (3), 15897321 (3), 16357361 (3) (see all 72)
    acyl-coa 74.9 13 15294040 (2), 11724471 (2), 14749206 (1), 19535819 (1) (see all 10)
    triacylglycerol 60.9 1 15525872 (1)
    lipid 49 19 12818409 (2), 15767857 (1), 16788709 (1), 15294040 (1) (see all 10)
    rosiglitazone 47.9 4 17463056 (1), 10548525 (1)
    palmitate 39.9 5 15897321 (5)
    sterol 37.3 1 14749206 (1)
    oleic acid 36.6 6 15897321 (6)
    docosahexaenoic acid 33.4 1 18639956 (1)
    phospholipid 29.3 1 19523918 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC27A1 / S27A1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC27A1 gene: 
    NM_198580.1  

    Unigene Cluster for SLC27A1:

    Solute carrier family 27 (fatty acid transporter), member 1
    Hs.363138  [show with all ESTs]
    Unigene Representative Sequence: AK131101
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000600277 ENST00000252595(uc002ngt.1 uc002ngu.1 uc010xpp.1 uc002ngv.1)
    ENST00000598424 ENST00000599380 ENST00000600297 ENST00000593701 ENST00000594962
    ENST00000598848 ENST00000599965 ENST00000442725
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    Additional mRNA sequence: 

    AK125289.1 AK131101.1 AK294238.1 AK296355.1 AK299852.1 AK315935.1 BC013149.1 BC059399.1 

    14 DOTS entries:

    DT.100740329  DT.100665893  DT.91798085  DT.428856  DT.101978022  DT.95155977  DT.95365597  DT.91747806 
    DT.100672981  DT.75146738  DT.99931620  DT.99996731  DT.99999022  DT.95321144 

    24/103 AceView cDNA sequences (see all 103):

    BG055011 CB241510 AI124693 BI766707 AI497962 BI488690 BF058556 BQ712480 
    BM741597 AI360113 BC059399 AI073915 AI357607 AW194786 NM_198580 BQ879802 
    BF569203 BX099013 BF509712 BQ006591 AI085579 AK131101 AI347907 CF456522 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SLC27A1 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
    SP1:                                                                                                                              
    SP2:                                                                                                                              
    SP3:                                      -                 -                                                                     
    SP4:                                                        -                                                                     
    SP5:        -           -                                                                                                         


    ECgene alternative splicing isoforms for SLC27A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC27A1 expression in normal human tissues (normalized intensities)      SLC27A1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAACTTTCC
    SLC27A1 Expression
    About this image


    SLC27A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Thalamus
             corpus callosum   
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Metencephalon
             spinal cord/lateral wall/ventricular layer   
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Spinal Cord (Nervous System)
             spinal cord/lateral wall/ventricular layer   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut

    See SLC27A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC27A1

    SOURCE GeneReport for Unigene cluster: Hs.363138

    UniProtKB/Swiss-Prot: S27A1_HUMAN, Q6PCB7
    Tissue specificity: Highest levels of expression are detected in muscle and adipose tissue small, intermediate
    levels in small intestine, and barely detectable in liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including SLC27A1: 
              Fatty Acid Metabolism in human mouse rat
              Insulin Resistance in human mouse rat
              PPAR Targets in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC27A1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc27a11 , 5 solute carrier family 27 (fatty acid transporter), more1, 5 84.52(n)1
    89.47(a)1
      8 (34.43 cM)5
    264571  NM_011977.31  NP_036107.11 
     715689275 
    chicken
    (Gallus gallus)
    Aves SLC27A11 solute carrier family 27 (fatty acid transporter), more 71.93(n)
    73.37(a)
      426008  NM_001039602.1  NP_001034691.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC27A16
    Uncharacterized protein
    71(a)
    1 ↔ 1
    GL343198.1(3819467-3861198)
    zebrafish
    (Danio rerio)
    Actinopterygii wufc10e122 Transcribed sequence with weak similarity to protein more 78.55(n)    BI428474.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG301946
    Fatp6
    (see all 3)
    Fatty acid (long chain) transport protein
    (see all 3)
    42(a)
    41(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2R(18943019-18949074)
    2L(10511252-10517216)
    worm
    (Caenorhabditis elegans)
    Secernentea acs-226
    acs-206
    Protein ACS-20
    40(a)
    38(a)
    many ↔ many
    many ↔ many
    X(8931241-8939261)
    IV(12392123-12398706)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FAT16
    Very long chain fatty acyl-CoA synthetase and long...
    27(a)
    1 → many
    II(318266-320275)


    ENSEMBL Gene Tree for SLC27A1 (if available)
    TreeFam Gene Tree for SLC27A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC27A1 gene
    SLC27A52  SLC27A22  SLC27A42  SLC27A32  SLC27A62  
    6 SIMAP similar genes for SLC27A1 using alignment to 6 protein entries:     S27A1_HUMAN (see all proteins):
    FLJ00336    SLC27A4    SLC27A3    SLC27A2    SLC27A6    SLC27A5

    SLC27A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/888 SNPs in SLC27A1 are shown (see all 888)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1832963471,2
    --17579438(+) GGCCTC/GTCCTC 1 -- us2k10--------
    rs1878807231,2
    --17579517(+) GTGAGA/TGCCTG 1 -- us2k10--------
    rs602836061,2
    C,F--17579581(+) AGAACG/TCTGGA 1 -- us2k12Minor allele frequency- T:0.16WA 120
    rs1434846081,2
    --17579778(+) TCCTGC/TCTGAG 1 -- us2k10--------
    rs1471621751,2
    C--17579948(+) GCGTGC/TGGATT 1 -- us2k10--------
    rs81093731,2
    C,F,A,H--17579984(+) TGACGG/TTGAGA 1 -- us2k1 tfbs330Minor allele frequency- T:0.14EA NA NS WA CSA 2983
    rs1910785461,2
    --17580090(+) CTGAGA/GCCCCA 1 -- us2k10--------
    rs621267751,2
    C,F--17580168(+) TTGGAC/TTTAGG 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs81108301,2
    C,A,H--17580183(+) GCTGGG/AGCAAG 1 -- us2k113Minor allele frequency- A:0.29NA WA CSA EA 376
    rs81137071,2
    C,F,A,H--17580226(+) GGGATT/ATTTTT 1 -- us2k113Minor allele frequency- A:0.21NS NA WA CSA EA 673

    HapMap Linkage Disequilibrium report for SLC27A1 (17579578 - 17616977 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SLC27A1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2677036CNV Deletion23128226
    nsv911182CNV Loss21882294
    dgv3761n71CNV Loss21882294
    dgv3762n71CNV Loss21882294
    nsv911205CNV Loss21882294
    nsv833768CNV Loss17160897
    nsv911203CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600691    OMIM disorders: --

    11 diseases for SLC27A1:    About MalaCards
    ichthyosis prematurity syndrome    ichthyosis    insulin resistance    metabolic disorders
    lipodystrophy    dilated cardiomyopathy    obesity    tuberculosis
    prostate cancer    prostatitis    endotheliitis


    SLC27A1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for SLC27A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin resistance 45.5 6 15767857 (4), 15168018 (1), 14715877 (1)
    obesity 38.3 1 15168018 (1)
    metabolic disorder 8.7 2 10873384 (1), 11970897 (1)

    Genetic Association Database (GAD): SLC27A1
    Human Genome Epidemiology (HuGE) Navigator: SLC27A1 (9 documents)

    Export disorders for SLC27A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC27A1 gene, integrated from 9 sources (see all 96):
    (articles sorted by number of sources associating them with SLC27A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression. (PubMed id 10873384)1, 2, 3, 9 Martin G.... Auwerx J. (2000)
    2. A common polymorphism in the fatty acid transport protein-1 gene associated with elevated post-prandial lipaemia and alterations in LDL particle size distribution. (PubMed id 12818409)1, 4, 9 Gertow K....Fisher R.M. (2003)
    3. Lack of association between certain candidate gene polymorphisms and the metabolic syndrome. (PubMed id 15978856)1, 4, 9 Meirhaeghe A....Dallongeville J. (2005)
    4. FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down- regulates sphingomyelin and cholesterol metabolism in growing 293 cells. (PubMed id 12235169)1, 2, 9 Hatch G.M.... Bernlohr D.A. (2002)
    5. Genome-wide pharmacogenetics of antidepressant respon se in the GENDEP project. (PubMed id 20360315)1, 4 Uher R....McGuffin P. (2010)
    6. Identification of type 2 diabetes-associated combinat ion of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells. (PubMed id 15897321)1, 9 Garcia-Martinez C....Gomez-Foix A.M. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 376497 HGNC: 10995 AceView: SLC27A1 Ensembl:ENSG00000130304 euGenes: HUgn376497
    ECgene: SLC27A1 Kegg: 376497 H-InvDB: SLC27A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC27A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC27A1 gene:
    Search GeneIP for patents involving SLC27A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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