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Aliases for SLC26A9 Gene

Aliases for SLC26A9 Gene

  • Solute Carrier Family 26 (Anion Exchanger), Member 9 2 3
  • Anion Transporter/Exchanger Protein 9 4
  • Solute Carrier Family 26, Member 9 2
  • Anion Transporter/Exchanger-9 2

External Ids for SLC26A9 Gene

Summaries for SLC26A9 Gene

Entrez Gene Summary for SLC26A9 Gene

  • This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. The product of this gene is a highly selective chloride ion channel regulated by WNK kinases. Alternative splicing results in multiple transcript variants encoding differing isoforms.[provided by RefSeq, Dec 2008]

GeneCards Summary for SLC26A9 Gene

SLC26A9 (Solute Carrier Family 26 (Anion Exchanger), Member 9) is a Protein Coding gene. Diseases associated with SLC26A9 include meconium ileus and ileus. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Mineral absorption. GO annotations related to this gene include secondary active sulfate transmembrane transporter activity. An important paralog of this gene is SLC26A2.

UniProtKB/Swiss-Prot for SLC26A9 Gene

  • DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. Inhibited by ammonium and thiosulfate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC26A9 Gene

Genomics for SLC26A9 Gene

Genomic Location for SLC26A9 Gene

Start:
205,913,048 bp from pter
End:
205,943,460 bp from pter
Size:
30,413 bases
Orientation:
Minus strand

Genomic View for SLC26A9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC26A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC26A9 Gene

Regulatory Elements for SLC26A9 Gene

Proteins for SLC26A9 Gene

  • Protein details for SLC26A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7LBE3-S26A9_HUMAN
    Recommended name:
    Solute carrier family 26 member 9
    Protein Accession:
    Q7LBE3
    Secondary Accessions:
    • A7E2V6
    • B1AVM8
    • B1AVM9
    • B7ZKK2
    • Q96PK9
    • Q96RN0

    Protein attributes for SLC26A9 Gene

    Size:
    791 amino acids
    Molecular mass:
    86988 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC26A9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC26A9 Gene

Proteomics data for SLC26A9 Gene at MOPED

Post-translational modifications for SLC26A9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC26A9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC26A9 Gene

Domains for SLC26A9 Gene

Gene Families for SLC26A9 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC26A9 Gene

UniProtKB/Swiss-Prot:

S26A9_HUMAN
Domain:
  • Contains 1 STAS domain.:
    • Q7LBE3
Family:
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.:
    • Q7LBE3
genes like me logo Genes that share domains with SLC26A9: view

Function for SLC26A9 Gene

Molecular function for SLC26A9 Gene

UniProtKB/Swiss-Prot Function: DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. Inhibited by ammonium and thiosulfate.

Gene Ontology (GO) - Molecular Function for SLC26A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005254 chloride channel activity IDA 17673510
GO:0008271 secondary active sulfate transmembrane transporter activity IEA --
GO:0015106 bicarbonate transmembrane transporter activity IEA --
GO:0015116 sulfate transmembrane transporter activity --
GO:0015301 anion:anion antiporter activity IDA 15800055
genes like me logo Genes that share ontologies with SLC26A9: view

Phenotypes for SLC26A9 Gene

MGI mutant phenotypes for SLC26A9:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SLC26A9: view

Animal Models for SLC26A9 Gene

MGI Knock Outs for SLC26A9:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC26A9 Gene

Localization for SLC26A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC26A9 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC26A9 Gene COMPARTMENTS Subcellular localization image for SLC26A9 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SLC26A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IDA 17673510
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IDA 20658517
genes like me logo Genes that share ontologies with SLC26A9: view

Pathways for SLC26A9 Gene

genes like me logo Genes that share pathways with SLC26A9: view

Interacting Proteins for SLC26A9 Gene

Gene Ontology (GO) - Biological Process for SLC26A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006820 anion transport IDA 11834742
GO:0006821 chloride transport IDA 15800055
GO:0006885 regulation of pH IEA --
GO:0008272 sulfate transport --
genes like me logo Genes that share ontologies with SLC26A9: view

Compounds for SLC26A9 Gene

(2) HMDB Compounds for SLC26A9 Gene

Compound Synonyms Cas Number PubMed IDs
Chlorine
  • Cl2
16887-00-6
Hydrogen carbonate
  • Bicarbonate
71-52-3
genes like me logo Genes that share compounds with SLC26A9: view

Transcripts for SLC26A9 Gene

Unigene Clusters for SLC26A9 Gene

Solute carrier family 26, member 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A9 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a ·
SP1: - - - -
SP2: - - - -
SP3: - -
SP4:
SP5: - -
SP6:

ExUns: 22b ^ 23
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for SLC26A9 Gene

GeneLoc Exon Structure for
SLC26A9
ECgene alternative splicing isoforms for
SLC26A9

Expression for SLC26A9 Gene

mRNA expression in normal human tissues for SLC26A9 Gene

mRNA differential expression in normal tissues according to GTEx for SLC26A9 Gene

This gene is overexpressed in Stomach (15.9), Heart - Left Ventricle (6.6), Lung (6.6), and Heart - Atrial Appendage (5.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC26A9 Gene

SOURCE GeneReport for Unigene cluster for SLC26A9 Gene Hs.164073

mRNA Expression by UniProt/SwissProt for SLC26A9 Gene

Q7LBE3-S26A9_HUMAN
Tissue specificity: Predominantly expressed in lung at the luminal side of the bronchiolar and alveolar epithelium of lung. To a lower extent, also expressed in pancreas and prostate.
genes like me logo Genes that share expressions with SLC26A9: view

Orthologs for SLC26A9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC26A9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC26A9 36
  • 99.49 (n)
  • 99.49 (a)
SLC26A9 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC26A9 36
  • 89.92 (n)
  • 90.34 (a)
SLC26A9 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC26A9 36
  • 90.3 (n)
  • 92.15 (a)
SLC26A9 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc26a9 36
  • 86.58 (n)
  • 89.87 (a)
Slc26a9 16
Slc26a9 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC26A9 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC26A9 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc26a9 36
  • 86.16 (n)
  • 89.37 (a)
chicken
(Gallus gallus)
Aves SLC26A9 36
  • 71.34 (n)
  • 72.31 (a)
SLC26A9 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC26A9 37
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc26a9 36
  • 64.17 (n)
  • 64.85 (a)
zebrafish
(Danio rerio)
Actinopterygii slc26a4 37
  • 34 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea W04G3.6 38
  • 33 (a)
K12G11.1 38
  • 27 (a)
Species with no ortholog for SLC26A9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC26A9 Gene

ENSEMBL:
Gene Tree for SLC26A9 (if available)
TreeFam:
Gene Tree for SLC26A9 (if available)

Paralogs for SLC26A9 Gene

Selected SIMAP similar genes for SLC26A9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC26A9: view

Variants for SLC26A9 Gene

Sequence variations from dbSNP and Humsavar for SLC26A9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs807427 -- 205,924,976(-) ctcta(G/T)aaaaa intron-variant
rs812747 -- 205,928,184(-) attCA(A/G)ACTGG intron-variant
rs1692017 -- 205,925,389(-) CTTTA(A/G)AGGAA intron-variant
rs2000181 -- 205,930,686(+) GGGCC(C/T)TCTAC intron-variant
rs2282429 -- 205,912,696(+) CTAAG(C/T)AACGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SLC26A9 Gene

Variant ID Type Subtype PubMed ID
nsv832392 CNV Gain 17160897
nsv470777 CNV Loss 18288195
esv29758 CNV Gain 19812545

Relevant External Links for SLC26A9 Gene

HapMap Linkage Disequilibrium report
SLC26A9
Human Gene Mutation Database (HGMD)
SLC26A9

Disorders for SLC26A9 Gene

(2) MalaCards Diseases for SLC26A9 Gene

Search for SLC26A9 Gene in MalaCards »

Relevant External Links for SLC26A9

Genetic Association Database (GAD)
SLC26A9
Human Genome Epidemiology (HuGE) Navigator
SLC26A9
genes like me logo Genes that share disorders with SLC26A9: view

No data available for UniProtKB/Swiss-Prot for SLC26A9 Gene

Publications for SLC26A9 Gene

  1. Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. (PMID: 11834742) Lohi H. … Kere J. (J. Biol. Chem. 2002) 2 3 4
  2. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 49
  3. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay J.L. … van den Oord E.J. (Neuropsychopharmacology 2011) 3 49
  4. SLC26A9 is expressed in gastric surface epithelial cells, mediates Cl-/HCO3- exchange, and is inhibited by NH4+. (PMID: 15800055) Xu J. … Soleimani M. (Am. J. Physiol. 2005) 3 4
  5. Functional analysis of nonsynonymous single nucleotide polymorphisms in human SLC26A9. (PMID: 22544634) Chen A.P. … Romero M.F. (Hum. Mutat. 2012) 3 4

Products for SLC26A9 Gene

Sources for SLC26A9 Gene

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