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Aliases for SLC26A9 Gene

Aliases for SLC26A9 Gene

  • Solute Carrier Family 26 Member 9 2 3 5
  • Solute Carrier Family 26 (Anion Exchanger), Member 9 2
  • Anion Transporter/Exchanger Protein 9 4
  • Solute Carrier Family 26, Member 9 2
  • Anion Transporter/Exchanger-9 2

External Ids for SLC26A9 Gene

Previous GeneCards Identifiers for SLC26A9 Gene

  • GC01M203885
  • GC01M201419
  • GC01M202243
  • GC01M203060
  • GC01M202613
  • GC01M204148
  • GC01M177045

Summaries for SLC26A9 Gene

Entrez Gene Summary for SLC26A9 Gene

  • This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. The product of this gene is a highly selective chloride ion channel regulated by WNK kinases. Alternative splicing results in multiple transcript variants encoding differing isoforms.[provided by RefSeq, Dec 2008]

GeneCards Summary for SLC26A9 Gene

SLC26A9 (Solute Carrier Family 26 Member 9) is a Protein Coding gene. Diseases associated with SLC26A9 include Meconium Ileus. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Mineral absorption. Gene Ontology (GO) annotations related to this gene include chloride channel activity and secondary active sulfate transmembrane transporter activity. An important paralog of this gene is SLC26A4.

UniProtKB/Swiss-Prot for SLC26A9 Gene

  • DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. Inhibited by ammonium and thiosulfate.

Additional gene information for SLC26A9 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC26A9 Gene

Genomics for SLC26A9 Gene

GeneHancer (GH) Regulatory Elements for SLC26A9 Gene

Promoters and enhancers for SLC26A9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I205943 Promoter/Enhancer 0.8 EPDnew ENCODE 550.8 0.0 -36 0.2 GATA3 SLC26A9 LOC103021296 LOC103021295
GH01I206046 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 -106.9 -106915 7.8 HDGF PKNOX1 FOXA2 ARID4B DMAP1 IRF4 ZNF48 ETS1 ZNF207 ZNF143 RHEX ELK4 EIF2D ENSG00000252692 RPL7AP20 CTSE AVPR1B ENSG00000226780 SLC26A9 TMCC2
GH01I205919 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.7 +24.2 24172 0.6 ELF3 HDGF RB1 IRF4 RAD21 RFX5 ARID2 ZNF143 ATF7 RCOR1 SLC26A9 ENSG00000226780 AVPR1B RAB29 LOC103021296 LOC284581
GH01I205791 Enhancer 1 ENCODE dbSUPER 11.3 +150.7 150671 2.2 HDGF CTCF USF1 RB1 RAD21 ZKSCAN1 CC2D1A CTBP1 POLR2A ARID2 PM20D1 RAB29 ELK4 DSTYK EIF2D SLC26A9 NUCKS1 GC01M205795 LOC105371702 SLC41A1
GH01I205786 Enhancer 1 ENCODE dbSUPER 10 +156.3 156307 1.6 HDAC1 HDGF ATF1 RB1 GATA2 ATF7 KDM4B CREM ZEB2 ZNF592 RAB29 PM20D1 SLC41A1 NUCKS1 SLC26A9 GC01M205795 LOC105371702
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC26A9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC26A9 gene promoter:

Genomic Locations for SLC26A9 Gene

Genomic Locations for SLC26A9 Gene
chr1:205,913,048-205,943,472
(GRCh38/hg38)
Size:
30,425 bases
Orientation:
Minus strand
chr1:205,882,176-205,912,588
(GRCh37/hg19)

Genomic View for SLC26A9 Gene

Genes around SLC26A9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC26A9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC26A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC26A9 Gene

Proteins for SLC26A9 Gene

  • Protein details for SLC26A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7LBE3-S26A9_HUMAN
    Recommended name:
    Solute carrier family 26 member 9
    Protein Accession:
    Q7LBE3
    Secondary Accessions:
    • A7E2V6
    • B1AVM8
    • B1AVM9
    • B7ZKK2
    • Q96PK9
    • Q96RN0

    Protein attributes for SLC26A9 Gene

    Size:
    791 amino acids
    Molecular mass:
    86988 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC26A9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC26A9 Gene

Post-translational modifications for SLC26A9 Gene

No Post-translational modifications

Other Protein References for SLC26A9 Gene

No data available for DME Specific Peptides for SLC26A9 Gene

Domains & Families for SLC26A9 Gene

Gene Families for SLC26A9 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC26A9 Gene

Suggested Antigen Peptide Sequences for SLC26A9 Gene

Graphical View of Domain Structure for InterPro Entry

Q7LBE3

UniProtKB/Swiss-Prot:

S26A9_HUMAN :
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Family:
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
genes like me logo Genes that share domains with SLC26A9: view

Function for SLC26A9 Gene

Molecular function for SLC26A9 Gene

UniProtKB/Swiss-Prot Function:
DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. Inhibited by ammonium and thiosulfate.

Phenotypes From GWAS Catalog for SLC26A9 Gene

Gene Ontology (GO) - Molecular Function for SLC26A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005254 chloride channel activity TAS --
GO:0008271 secondary active sulfate transmembrane transporter activity IEA --
GO:0015106 bicarbonate transmembrane transporter activity IBA --
GO:0015116 sulfate transmembrane transporter activity IBA --
GO:0015301 anion:anion antiporter activity IDA 15800055
genes like me logo Genes that share ontologies with SLC26A9: view
genes like me logo Genes that share phenotypes with SLC26A9: view

Animal Models for SLC26A9 Gene

MGI Knock Outs for SLC26A9:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC26A9 Gene

Localization for SLC26A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC26A9 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC26A9 gene
Compartment Confidence
plasma membrane 5
extracellular 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC26A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0009986 cell surface IDA 17673510
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC26A9: view

Pathways & Interactions for SLC26A9 Gene

genes like me logo Genes that share pathways with SLC26A9: view

Gene Ontology (GO) - Biological Process for SLC26A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006820 anion transport IDA 11834742
GO:0006821 chloride transport IDA,IEA 15800055
GO:0008272 sulfate transport IEA --
GO:0010628 positive regulation of gene expression IDA 20658517
genes like me logo Genes that share ontologies with SLC26A9: view

No data available for SIGNOR curated interactions for SLC26A9 Gene

Drugs & Compounds for SLC26A9 Gene

(1) Drugs for SLC26A9 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ivacaftor Approved Pharma 0

(2) Additional Compounds for SLC26A9 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
Hydrogen carbonate
  • Bicarbonate
  • Bicarbonate (HCO3-)
  • Bicarbonate anion
  • Bicarbonate ion
  • Bicarbonate ion (HCO31-)
71-52-3
genes like me logo Genes that share compounds with SLC26A9: view

Transcripts for SLC26A9 Gene

Unigene Clusters for SLC26A9 Gene

Solute carrier family 26, member 9:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A9 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a ·
SP1: - - - -
SP2: - - - -
SP3: - -
SP4:
SP5: - -
SP6:

ExUns: 22b ^ 23
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for SLC26A9 Gene

GeneLoc Exon Structure for
SLC26A9
ECgene alternative splicing isoforms for
SLC26A9

Expression for SLC26A9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC26A9 Gene

mRNA differential expression in normal tissues according to GTEx for SLC26A9 Gene

This gene is overexpressed in Stomach (x15.9), Heart - Left Ventricle (x6.6), Lung (x6.6), and Heart - Atrial Appendage (x5.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC26A9 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC26A9 Gene:

SLC26A9

SOURCE GeneReport for Unigene cluster for SLC26A9 Gene:

Hs.164073

mRNA Expression by UniProt/SwissProt for SLC26A9 Gene:

Q7LBE3-S26A9_HUMAN
Tissue specificity: Predominantly expressed in lung at the luminal side of the bronchiolar and alveolar epithelium of lung. To a lower extent, also expressed in pancreas and prostate.

Evidence on tissue expression from TISSUES for SLC26A9 Gene

  • Stomach(2.5)
genes like me logo Genes that share expression patterns with SLC26A9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC26A9 Gene

Orthologs for SLC26A9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC26A9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC26A9 33 34
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia SLC26A9 33 34
  • 90.3 (n)
cow
(Bos Taurus)
Mammalia SLC26A9 33 34
  • 89.92 (n)
mouse
(Mus musculus)
Mammalia Slc26a9 33 16 34
  • 86.58 (n)
rat
(Rattus norvegicus)
Mammalia Slc26a9 33
  • 86.16 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC26A9 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC26A9 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC26A9 33 34
  • 71.34 (n)
lizard
(Anolis carolinensis)
Reptilia SLC26A9 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc26a9 33
  • 64.17 (n)
zebrafish
(Danio rerio)
Actinopterygii slc26a4 34
  • 34 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea W04G3.6 35
  • 33 (a)
K12G11.1 35
  • 27 (a)
Species where no ortholog for SLC26A9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC26A9 Gene

ENSEMBL:
Gene Tree for SLC26A9 (if available)
TreeFam:
Gene Tree for SLC26A9 (if available)

Paralogs for SLC26A9 Gene

(12) SIMAP similar genes for SLC26A9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC26A9: view

Variants for SLC26A9 Gene

Sequence variations from dbSNP and Humsavar for SLC26A9 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs12759719 benign, not specified 205,921,551(-) T/C genic_downstream_transcript_variant, intron_variant
rs16856462 benign, not specified 205,918,853(-) T/C coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs16856470 benign, not specified 205,920,201(-) C/T coding_sequence_variant, genic_downstream_transcript_variant, non_coding_transcript_variant, synonymous_variant
rs6669481 benign, not specified 205,915,146(-) T/C 3_prime_UTR_variant, coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs9438438 benign, not specified 205,914,934(-) T/C 3_prime_UTR_variant, coding_sequence_variant, genic_downstream_transcript_variant, non_coding_transcript_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC26A9 Gene

Variant ID Type Subtype PubMed ID
esv29758 CNV gain 19812545
nsv470777 CNV loss 18288195
nsv473847 CNV novel sequence insertion 20440878
nsv475020 CNV novel sequence insertion 20440878
nsv475104 CNV novel sequence insertion 20440878
nsv475370 CNV novel sequence insertion 20440878
nsv475664 CNV novel sequence insertion 20440878
nsv476104 CNV novel sequence insertion 20440878
nsv476362 CNV novel sequence insertion 20440878
nsv476521 CNV novel sequence insertion 20440878
nsv476747 CNV novel sequence insertion 20440878
nsv479107 CNV novel sequence insertion 20440878
nsv479203 CNV novel sequence insertion 20440878
nsv479207 CNV novel sequence insertion 20440878
nsv479422 CNV novel sequence insertion 20440878
nsv479511 CNV novel sequence insertion 20440878
nsv479830 CNV novel sequence insertion 20440878
nsv479879 CNV novel sequence insertion 20440878
nsv480249 CNV novel sequence insertion 20440878
nsv480339 CNV novel sequence insertion 20440878
nsv480749 CNV novel sequence insertion 20440878
nsv480812 CNV novel sequence insertion 20440878
nsv480833 CNV novel sequence insertion 20440878
nsv480933 CNV novel sequence insertion 20440878
nsv481089 CNV novel sequence insertion 20440878
nsv481232 CNV novel sequence insertion 20440878
nsv481550 CNV novel sequence insertion 20440878
nsv481605 CNV novel sequence insertion 20440878
nsv549045 CNV loss 21841781
nsv832392 CNV gain 17160897

Variation tolerance for SLC26A9 Gene

Residual Variation Intolerance Score: 61.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.30; 62.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC26A9 Gene

Human Gene Mutation Database (HGMD)
SLC26A9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC26A9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC26A9 Gene

Disorders for SLC26A9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC26A9 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
meconium ileus
  • intestinal obstruction in the newborn due to guanylate cyclase 2c deficiency
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC26A9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC26A9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC26A9 Gene

Publications for SLC26A9 Gene

  1. Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. (PMID: 11834742) Lohi H … Kere J (The Journal of biological chemistry 2002) 2 3 4 58
  2. Functional analysis of nonsynonymous single nucleotide polymorphisms in human SLC26A9. (PMID: 22544634) Chen AP … Romero MF (Human mutation 2012) 3 4 58
  3. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay JL … van den Oord EJ (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011) 3 44 58
  4. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 44 58
  5. SLC26A9 is expressed in gastric surface epithelial cells, mediates Cl-/HCO3- exchange, and is inhibited by NH4+. (PMID: 15800055) Xu J … Soleimani M (American journal of physiology. Cell physiology 2005) 3 4 58

Products for SLC26A9 Gene

Sources for SLC26A9 Gene

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