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SLC26A9 Gene

protein-coding   GIFtS: 56
GCID: GC01M205883

Solute Carrier Family 26 (Anion Exchanger), Member 9

(Previous names: solute carrier family 26, member 9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 26 (Anion Exchanger), Member 91 2
Solute Carrier Family 26, Member 91 2
Anion Transporter/Exchanger-91 2
Anion Transporter/Exchanger Protein 92 3
Solute Carrier Family 26 Member 92

External Ids:    HGNC: 144691   Entrez Gene: 1150192   Ensembl: ENSG000001745027   OMIM: 6084815   UniProtKB: Q7LBE33   

Export aliases for SLC26A9 gene to outside databases

Previous GC identifers: GC01M203885 GC01M201419 GC01M202243 GC01M203060 GC01M202613 GC01M204148 GC01M177045


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC26A9 Gene:
This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their
genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different
tissue expression patterns. The product of this gene is a highly selective chloride ion channel regulated by WNK
kinases. Alternative splicing results in multiple transcript variants encoding differing isoforms.(provided by
RefSeq, Dec 2008)

GeneCards Summary for SLC26A9 Gene:
SLC26A9 (solute carrier family 26 (anion exchanger), member 9) is a protein-coding gene. Diseases associated with SLC26A9 include meconium ileus, and ileus. GO annotations related to this gene include secondary active sulfate transmembrane transporter activity. An important paralog of this gene is SLC26A3.

UniProtKB/Swiss-Prot: S26A9_HUMAN, Q7LBE3
Function: DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport.
Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate
secretion. Inhibited by ammonium and thiosulfate




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC26A9 gene promoter:
         MZF-1   Spz1   NF-1/L   NF-1   GATA-3   HTF   FOXD3   Cdc5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC26A9 promoter sequence
   Search Chromatin IP Primers for SLC26A9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC26A9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

SLC26A9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC26A9 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M205883:  view genomic region     (about GC identifiers)

Start:
205,882,176 bp from pter      End:
205,912,588 bp from pter
Size:
30,413 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S26A9_HUMAN, Q7LBE3 (See protein sequence)
Recommended Name: Solute carrier family 26 member 9  
Size: 791 amino acids; 86988 Da
Sequence caution: Sequence=AAL26867.1; Type=Erroneous termination; Positions=792; Note=Translated as stop;
Sequence=EAW91587.1; Type=Erroneous termination; Positions=792; Note=Translated as stop;
Secondary accessions: A7E2V6 B1AVM9 B7ZKK2 Q96PK9 Q96RN0

Explore the universe of human proteins at neXtProt for SLC26A9: NX_Q7LBE3

Explore proteomics data for SLC26A9 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC26A9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_443166.1  NP_599152.2  

    ENSEMBL proteins: 
     ENSP00000341682   ENSP00000356103   ENSP00000356102  
    Reactome Protein details: Q7LBE3

    SLC26A9 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: SLC26A9
    Anion channels

    3 InterPro protein domains:
     IPR002645 STAS_dom
     IPR001902 SulP_transpt
     IPR011547 Sulph_transpt

    Graphical View of Domain Structure for InterPro Entry Q7LBE3

    ProtoNet protein and cluster: Q7LBE3

    1 Blocks protein domain: IPB001902 Sulphate transporter

    UniProtKB/Swiss-Prot: S26A9_HUMAN, Q7LBE3
    Similarity: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family
    Similarity: Contains 1 STAS domain


    SLC26A9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S26A9_HUMAN, Q7LBE3
    Function: DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport.
    Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate
    secretion. Inhibited by ammonium and thiosulfate

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005254chloride channel activity IDA17673510
    GO:0008271secondary active sulfate transmembrane transporter activity IEA--
    GO:0015106bicarbonate transmembrane transporter activity ----
    GO:0015116sulfate transmembrane transporter activity ----
    GO:0015301anion:anion antiporter activity IDA15800055
         
    SLC26A9 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Slc26a9):
     digestive/alimentary 

    SLC26A9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Slc26a9tm1Sole for SLC26A9

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC26A9
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    hsa-miR-2052 hsa-miR-4254 hsa-miR-3194-5p hsa-miR-1321 hsa-miR-513a-5p hsa-miR-649 hsa-miR-378 hsa-miR-556-3p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S26A9_HUMAN, Q7LBE3: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface IDA17673510
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0016324apical plasma membrane IDA--

    SLC26A9 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC26A9 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Multifunctional anion exchangers0.00
    2Mineral absorption
    Mineral absorption

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC26A9
        Multifunctional anion exchangers


    1 Kegg Pathway  (Kegg details for SLC26A9):
        Mineral absorption


    SLC26A9 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC26A9
    Interactions:

        Search GeneGlobe Interaction Network for SLC26A9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for SLC26A9 (Q7LBE33 ENSP000003416824) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CFTRP135693I2D: score=1 
    ENSG00000225553ENSP000003919014STRING: ENSP00000391901
    ENSG00000231618ENSP000004062194STRING: ENSP00000406219
    GCSAMENSP000003094874STRING: ENSP00000309487
    KIF21BENSP000003284944STRING: ENSP00000328494
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006820anion transport IDA11834742
    GO:0006821chloride transport IDA15800055
    GO:0006885regulation of pH ----
    GO:0008272sulfate transport ----

    SLC26A9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC26A9 (S26A9)

    2 HMDB Compounds for SLC26A9    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    Hydrogen carbonateBicarbonate (see all 19)71-52-3--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC26A9 gene (3 alternative transcripts): 
    NM_052934.3  NM_134325.2  NM_001142600.1  

    Unigene Cluster for SLC26A9:

    Solute carrier family 26, member 9
    Hs.164073  [show with all ESTs]
    Unigene Representative Sequence: AF331525
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340781 ENST00000367135(uc001hdm.3 uc001hdn.3 uc001hdp.3 uc001hdq.3)
    ENST00000491127(uc001hdo.3) ENST00000461505 ENST00000469392 ENST00000367134

    miRNA
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    hsa-miR-2052 hsa-miR-4254 hsa-miR-3194-5p hsa-miR-1321 hsa-miR-513a-5p hsa-miR-649 hsa-miR-378 hsa-miR-556-3p
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    Additional mRNA sequence: 

    AF314958.1 AF331525.1 AK091876.1 AK127491.1 BC037978.1 BC136538.1 BC144233.1 BC151208.1 

    3 DOTS entries:

    DT.40267422  DT.100688261  DT.97821000 

    24 AceView cDNA sequences:

    AX747232 NM_052934 AK091876 BI869085 AF331525 AA862421 BU158718 AK127491 
    NM_134325 BC037978 BX484746 AI432108 BQ961349 AF314958 AW514334 AJ708138 
    BQ896842 BX484774 BI832996 AW192778 CB958492 AI828448 CD636350 AI932662 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A9 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a ·
    SP1:                                      -                       -                                                           -                 -               
    SP2:                                      -                       -                                                           -                 -               
    SP3:                                                                                                                          -                 -               
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                      -     -               

    ExUns: 22b ^ 23
    SP1:  -         
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for SLC26A9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC26A9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGCAGAGGG
    SLC26A9 Expression
    About this image

    SLC26A9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC26A9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.164073

    UniProtKB/Swiss-Prot: S26A9_HUMAN, Q7LBE3
    Tissue specificity: Predominantly expressed in lung at the luminal side of the bronchiolar and alveolar epithelium
    of lung. To a lower extent, also expressed in pancreas and prostate

        Custom PCR Arrays for SLC26A9
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLC26A9 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc26a91 , 5 solute carrier family 26, member 91, 5 86.58(n)1
    89.87(a)1
      1 (57.18 cM)5
    3207181  NM_177243.41  NP_796217.21 
     1317440225 
    chicken
    (Gallus gallus)
    Aves SLC26A91 solute carrier family 26, member 9 71.34(n)
    72.31(a)
      428262  XM_425821.3  XP_425821.2 
    lizard
    (Anolis carolinensis)
    Reptilia SLC26A96
    solute carrier family 26 (anion exchanger), member...
    67(a)
    1 ↔ 1
    GL343228.1(791752-865439)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc26a91 solute carrier family 26 (anion exchanger), member more 64.17(n)
    64.85(a)
      100124761  NM_001102740.1  NP_001096210.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc26a46
    solute carrier family 26, member 4
    34(a)
    many ↔ many
    4(17850723-17865087) ENSDARG00000069431


    ENSEMBL Gene Tree for SLC26A9 (if available)
    TreeFam Gene Tree for SLC26A9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC26A9 gene
    SLC26A32  SLC26A62  SLC26A12  SLC26A52  SLC26A112  SLC26A22  SLC26A102  SLC26A72  
    SLC26A42  SLC26A82  
    12 SIMAP similar genes for SLC26A9 using alignment to 2 protein entries:     S26A9_HUMAN (see all proteins):
    DKFZp686P10213    RESDA1    PRES    SLC26A4    SLC26A5    SLC26A3
    SLC26A10    SLC26A7    SLC26A6    SLC26A2    SLC26A1    SLC26A8

    SLC26A9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC26A9 (see all 940)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1824086241,2
    C--205881753(+) CTCACA/GAACAG 2 -- ds50010--------
    rs1866856431,2
    --205881820(+) TTTGCA/TAAGTA 2 -- ds50010--------
    rs22824291,2
    C,F,O,H--205881824(+) CTAAGT/CAACGA 2 -- ds500123Minor allele frequency- C:0.28EA NA NS WA 4044
    rs1474776831,2
    C--205881827(+) AGTAAC/TGATGG 2 -- ds50010--------
    rs1925732411,2
    --205881829(+) TAACGA/GTGGGA 2 -- ds50010--------
    rs115833961,2
    H--205881995(+) CTTTAG/ACTGGA 2 -- ds50014Minor allele frequency- A:0.00NS EA 420
    rs1151724551,2
    C,F--205882035(+) AAAATC/GGAACC 2 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1832543961,2
    --205882073(+) AAATCA/TGAGTC 2 -- ds50010--------
    rs1890353331,2
    --205882093(+) TCCCCC/TGCCCG 2 -- ds50010--------
    rs1929799601,2
    --205882164(+) CCACCC/GAAACA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for SLC26A9 (205882176 - 205912588 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SLC26A9:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv470777CNV Loss18288195
    nsv832392CNV Gain17160897
    esv29758CNV Gain19812545

    Human Gene Mutation Database (HGMD): SLC26A9
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC26A9
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC26A9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608481    OMIM disorders: --

    11 diseases for SLC26A9:    
    About MalaCards
    meconium ileus    ileus    diastrophic dysplasia    fainting
    cystic fibrosis    hepatitis c virus    hepatitis c    schizophrenia
    tuberculosis    hepatitis    prostatitis


    SLC26A9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC26A9
    Human Genome Epidemiology (HuGE) Navigator: SLC26A9 (2 documents)

    Export disorders for SLC26A9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC26A9 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with SLC26A9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. (PubMed id 11834742)1, 2, 3 Lohi H.... Kere J. (J. Biol. Chem. 2002)
    2. Functional analysis of nonsynonymous single nucleotide polymorphisms in human SLC26A9. (PubMed id 22544634)1, 2 Chen A.P.... Romero M.F. (Hum. Mutat. 2012)
    3. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PubMed id 21107309)1, 4 McClay J.L....van den Oord E.J. (Neuropsychopharmacology 2011)
    4. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    5. SLC26A9 is expressed in gastric surface epithelial cells, mediates Cl-/HCO3- exchange, and is inhibited by NH4+. (PubMed id 15800055)1, 2 Xu J.... Soleimani M. (Am. J. Physiol. 2005)
    6. Genetic modifiers of cystic fibrosis-related diabetes. (PubMed id 23670970)1 Blackman S.M....Cutting G.R. (Diabetes 2013)
    7. SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation. (PubMed id 22945630)1 Anagnostopoulou P....Mall M.A. (J. Clin. Invest. 2012)
    8. Differential contribution of SLC26A9 to Cl(-) conductance in polarized and non-polarized epithelial cells. (PubMed id 21809345)1 Ousingsawat J....Kunzelmann K. (J. Cell. Physiol. 2012)
    9. Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis. (PubMed id 22466613)1 Sun L....Strug L.J. (Nat. Genet. 2012)
    10. Characterization of the L683P mutation of SLC26A9 in Xenopus oocytes. (PubMed id 21439353)1 Avella M....Ehrenfeld J. (Biochim. Biophys. Acta 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 115019 HGNC: 14469 AceView: SLC26A9 Ensembl:ENSG00000174502 euGenes: HUgn115019
    ECgene: SLC26A9 Kegg: 115019 H-InvDB: SLC26A9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC26A9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC26A9 gene:
    Search GeneIP for patents involving SLC26A9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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