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Aliases for SLC26A9 Gene

Aliases for SLC26A9 Gene

  • Solute Carrier Family 26 Member 9 2 3
  • Solute Carrier Family 26 (Anion Exchanger), Member 9 2 5
  • Anion Transporter/Exchanger Protein 9 4
  • Solute Carrier Family 26, Member 9 2
  • Anion Transporter/Exchanger-9 2

External Ids for SLC26A9 Gene

Previous GeneCards Identifiers for SLC26A9 Gene

  • GC01M203885
  • GC01M201419
  • GC01M202243
  • GC01M203060
  • GC01M202613
  • GC01M204148
  • GC01M177045

Summaries for SLC26A9 Gene

Entrez Gene Summary for SLC26A9 Gene

  • This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. The product of this gene is a highly selective chloride ion channel regulated by WNK kinases. Alternative splicing results in multiple transcript variants encoding differing isoforms.[provided by RefSeq, Dec 2008]

GeneCards Summary for SLC26A9 Gene

SLC26A9 (Solute Carrier Family 26 Member 9) is a Protein Coding gene. Diseases associated with SLC26A9 include meconium ileus and cystic fibrosis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Mineral absorption. GO annotations related to this gene include chloride channel activity and secondary active sulfate transmembrane transporter activity. An important paralog of this gene is SLC26A2.

UniProtKB/Swiss-Prot for SLC26A9 Gene

  • DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. Inhibited by ammonium and thiosulfate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC26A9 Gene

Genomics for SLC26A9 Gene

Regulatory Elements for SLC26A9 Gene

Genomic Location for SLC26A9 Gene

Chromosome:
1
Start:
205,913,048 bp from pter
End:
205,943,472 bp from pter
Size:
30,425 bases
Orientation:
Minus strand

Genomic View for SLC26A9 Gene

Genes around SLC26A9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC26A9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC26A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC26A9 Gene

Proteins for SLC26A9 Gene

  • Protein details for SLC26A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7LBE3-S26A9_HUMAN
    Recommended name:
    Solute carrier family 26 member 9
    Protein Accession:
    Q7LBE3
    Secondary Accessions:
    • A7E2V6
    • B1AVM8
    • B1AVM9
    • B7ZKK2
    • Q96PK9
    • Q96RN0

    Protein attributes for SLC26A9 Gene

    Size:
    791 amino acids
    Molecular mass:
    86988 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC26A9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC26A9 Gene

Proteomics data for SLC26A9 Gene at MOPED

Post-translational modifications for SLC26A9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC26A9 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SLC26A9

No data available for DME Specific Peptides for SLC26A9 Gene

Domains & Families for SLC26A9 Gene

Gene Families for SLC26A9 Gene

Protein Domains for SLC26A9 Gene

Suggested Antigen Peptide Sequences for SLC26A9 Gene

Graphical View of Domain Structure for InterPro Entry

Q7LBE3

UniProtKB/Swiss-Prot:

S26A9_HUMAN :
  • Contains 1 STAS domain.
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Domain:
  • Contains 1 STAS domain.
Family:
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
genes like me logo Genes that share domains with SLC26A9: view

Function for SLC26A9 Gene

Molecular function for SLC26A9 Gene

UniProtKB/Swiss-Prot Function:
DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. Inhibited by ammonium and thiosulfate.

Gene Ontology (GO) - Molecular Function for SLC26A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019531 oxalate transmembrane transporter activity IBA --
GO:0051117 ATPase binding IPI 19289574
genes like me logo Genes that share ontologies with SLC26A9: view
genes like me logo Genes that share phenotypes with SLC26A9: view

Animal Models for SLC26A9 Gene

MGI Knock Outs for SLC26A9:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC26A9

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC26A9 Gene

Localization for SLC26A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC26A9 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC26A9 Gene COMPARTMENTS Subcellular localization image for SLC26A9 gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC26A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC26A9: view

Pathways & Interactions for SLC26A9 Gene

genes like me logo Genes that share pathways with SLC26A9: view

Interacting Proteins for SLC26A9 Gene

Gene Ontology (GO) - Biological Process for SLC26A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006821 chloride transport IDA 15800055
GO:0008272 sulfate transport IEA --
GO:0019532 oxalate transport IBA --
GO:0042391 regulation of membrane potential IBA --
GO:0051453 regulation of intracellular pH IBA --
genes like me logo Genes that share ontologies with SLC26A9: view

No data available for SIGNOR curated interactions for SLC26A9 Gene

Drugs & Compounds for SLC26A9 Gene

(2) Additional Compounds for SLC26A9 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
Hydrogen carbonate
  • Bicarbonate
  • Bicarbonate (HCO3-)
  • Bicarbonate anion
  • Bicarbonate ion
  • Bicarbonate ion (HCO31-)
71-52-3
genes like me logo Genes that share compounds with SLC26A9: view

Transcripts for SLC26A9 Gene

Unigene Clusters for SLC26A9 Gene

Solute carrier family 26, member 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A9 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a ·
SP1: - - - -
SP2: - - - -
SP3: - -
SP4:
SP5: - -
SP6:

ExUns: 22b ^ 23
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for SLC26A9 Gene

GeneLoc Exon Structure for
SLC26A9
ECgene alternative splicing isoforms for
SLC26A9

Expression for SLC26A9 Gene

mRNA expression in normal human tissues for SLC26A9 Gene

mRNA differential expression in normal tissues according to GTEx for SLC26A9 Gene

This gene is overexpressed in Stomach (x15.9), Heart - Left Ventricle (x6.6), Lung (x6.6), and Heart - Atrial Appendage (x5.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC26A9 Gene



SOURCE GeneReport for Unigene cluster for SLC26A9 Gene Hs.164073

mRNA Expression by UniProt/SwissProt for SLC26A9 Gene

Q7LBE3-S26A9_HUMAN
Tissue specificity: Predominantly expressed in lung at the luminal side of the bronchiolar and alveolar epithelium of lung. To a lower extent, also expressed in pancreas and prostate.
genes like me logo Genes that share expression patterns with SLC26A9: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for SLC26A9 Gene

Orthologs for SLC26A9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC26A9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC26A9 35
  • 99.49 (n)
  • 99.49 (a)
SLC26A9 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC26A9 36
  • 90 (a)
OneToOne
SLC26A9 35
  • 89.92 (n)
  • 90.34 (a)
dog
(Canis familiaris)
Mammalia SLC26A9 35
  • 90.3 (n)
  • 92.15 (a)
SLC26A9 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc26a9 16
Slc26a9 35
  • 86.58 (n)
  • 89.87 (a)
Slc26a9 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC26A9 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC26A9 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc26a9 35
  • 86.16 (n)
  • 89.37 (a)
chicken
(Gallus gallus)
Aves SLC26A9 35
  • 71.34 (n)
  • 72.31 (a)
SLC26A9 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC26A9 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc26a9 35
  • 64.17 (n)
  • 64.85 (a)
zebrafish
(Danio rerio)
Actinopterygii slc26a4 36
  • 34 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea K12G11.1 37
  • 27 (a)
W04G3.6 37
  • 33 (a)
Species with no ortholog for SLC26A9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC26A9 Gene

ENSEMBL:
Gene Tree for SLC26A9 (if available)
TreeFam:
Gene Tree for SLC26A9 (if available)

Paralogs for SLC26A9 Gene

(12) SIMAP similar genes for SLC26A9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC26A9: view

Variants for SLC26A9 Gene

Sequence variations from dbSNP and Humsavar for SLC26A9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3811428 - 205,918,866(-) GAGAC(A/G)TGACC intron-variant, reference, missense
rs16856462 - 205,918,853(+) AGTTG(C/T)GTCCT intron-variant, reference, missense
VAR_068683 -
rs77497889 - 205,932,032(+) CAAAG(G/T)TACCT intron-variant, nc-transcript-variant, reference, missense
rs112659452 - 205,927,556(+) CATGA(A/G)TTTTA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SLC26A9 Gene

Variant ID Type Subtype PubMed ID
nsv832392 CNV Gain 17160897
nsv470777 CNV Loss 18288195
esv29758 CNV Gain 19812545

Variation tolerance for SLC26A9 Gene

Residual Variation Intolerance Score: 61.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.30; 62.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC26A9 Gene

HapMap Linkage Disequilibrium report
SLC26A9
Human Gene Mutation Database (HGMD)
SLC26A9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC26A9 Gene

Disorders for SLC26A9 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC26A9 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
meconium ileus
  • mecil
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC26A9

Genetic Association Database (GAD)
SLC26A9
Human Genome Epidemiology (HuGE) Navigator
SLC26A9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC26A9
genes like me logo Genes that share disorders with SLC26A9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC26A9 Gene

Publications for SLC26A9 Gene

  1. Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. (PMID: 11834742) Lohi H. … Kere J. (J. Biol. Chem. 2002) 2 3 4 67
  2. Variants in Solute Carrier SLC26A9 Modify Prenatal Exocrine Pancreatic Damage in Cystic Fibrosis. (PMID: 25771386) Miller M.R. … Strug L.J. (J. Pediatr. 2015) 3
  3. Genetic loci associated with circulating levels of very long-chain saturated fatty acids. (PMID: 25378659) Lemaitre R.N. … Friedlander Y. (J. Lipid Res. 2015) 3
  4. N-glycosylation and topology of the human SLC26 family of anion transport membrane proteins. (PMID: 24647542) Li J. … Reithmeier R.A. (Am. J. Physiol., Cell Physiol. 2014) 3
  5. Characterization of SLC26A9 in patients with CF-like lung disease. (PMID: 24272871) Bakouh N. … Sermet-Gaudelus I. (Hum. Mutat. 2013) 3

Products for SLC26A9 Gene

Sources for SLC26A9 Gene

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