Aliases for SLC26A9 Gene
External Ids for SLC26A9 Gene
Previous GeneCards Identifiers for SLC26A9 Gene
This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. The product of this gene is a highly selective chloride ion channel regulated by WNK kinases. Alternative splicing results in multiple transcript variants encoding differing isoforms.[provided by RefSeq, Dec 2008]
GeneCards Summary for SLC26A9 Gene
SLC26A9 (Solute Carrier Family 26 Member 9) is a Protein Coding gene. Diseases associated with SLC26A9 include Meconium Ileus and Cystic Fibrosis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Mineral absorption. GO annotations related to this gene include chloride channel activity and secondary active sulfate transmembrane transporter activity. An important paralog of this gene is SLC26A5.
UniProtKB/Swiss-Prot for SLC26A9 Gene
DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. Inhibited by ammonium and thiosulfate.