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Aliases for SLC26A8 Gene

Aliases for SLC26A8 Gene

  • Solute Carrier Family 26 (Anion Exchanger), Member 8 2 3
  • TAT1 3 4 6
  • SPGF3 3 6
  • Solute Carrier Family 26, Member 8 2
  • Solute Carrier Family 26 Member 8 4
  • Anion Transporter/Exchanger-8 3
  • Testis Anion Transporter 1 3
  • Anion Exchange Transporter 4

External Ids for SLC26A8 Gene

Previous GeneCards Identifiers for SLC26A8 Gene

  • GC06M035913
  • GC06M035958
  • GC06M036019
  • GC06M035911
  • GC06M035631

Summaries for SLC26A8 Gene

Entrez Gene Summary for SLC26A8 Gene

  • This gene encodes a member of the SLC26 gene family of anion transporters. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. The expression of this gene appears to be restricted to spermatocytes. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2010]

GeneCards Summary for SLC26A8 Gene

SLC26A8 (Solute Carrier Family 26 (Anion Exchanger), Member 8) is a Protein Coding gene. Diseases associated with SLC26A8 include spermatogenic failure 3 and non-syndromic male infertility due to sperm motility disorder. Among its related pathways are Tenofovir/Adefovir Pathway, Pharmacokinetics. GO annotations related to this gene include chloride channel activity and anion:anion antiporter activity. An important paralog of this gene is SLC26A2.

UniProtKB/Swiss-Prot for SLC26A8 Gene

  • Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a moleculer complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation.

Gene Wiki entry for SLC26A8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC26A8 Gene

Genomics for SLC26A8 Gene

Regulatory Elements for SLC26A8 Gene

Transcription factor binding sites by QIAGEN in the SLC26A8 gene promoter:

Genomic Location for SLC26A8 Gene

Start:
35,943,514 bp from pter
End:
36,028,898 bp from pter
Size:
85,385 bases
Orientation:
Minus strand

Genomic View for SLC26A8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC26A8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC26A8 Gene

Proteins for SLC26A8 Gene

  • Protein details for SLC26A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RN1-S26A8_HUMAN
    Recommended name:
    Testis anion transporter 1
    Protein Accession:
    Q96RN1
    Secondary Accessions:
    • Q5JVR5
    • Q812C7
    • Q8TC65
    • Q96MA0
    • Q96PK8

    Protein attributes for SLC26A8 Gene

    Size:
    970 amino acids
    Molecular mass:
    109006 Da
    Quaternary structure:
    • Interacts with RACGAP1. Interacts with CFTR.
    SequenceCaution:
    • Sequence=AAO26699.1; Type=Miscellaneous discrepancy; Note=Incorrectly indicated as originating from mouse.; Evidence={ECO:0000305}; Sequence=BAB71408.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC26A8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC26A8 Gene

Proteomics data for SLC26A8 Gene at MOPED

Post-translational modifications for SLC26A8 Gene

Other Protein References for SLC26A8 Gene

No data available for DME Specific Peptides for SLC26A8 Gene

Domains for SLC26A8 Gene

Gene Families for SLC26A8 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC26A8 Gene

Suggested Antigen Peptide Sequences for SLC26A8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RN1

UniProtKB/Swiss-Prot:

S26A8_HUMAN :
  • Q96RN1
Domain:
  • Contains 1 STAS domain.
Family:
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
genes like me logo Genes that share domains with SLC26A8: view

Function for SLC26A8 Gene

Molecular function for SLC26A8 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Activity is inhibited by 4,4-Di-isothiocyanatostilbene-2,2-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters), gluconate, and by thiosulfate
UniProtKB/Swiss-Prot Function: Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a moleculer complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation.
UniProtKB/Swiss-Prot Induction: Repressed by tunicamycin, an inhibitor of N-glycosylation.

Gene Ontology (GO) - Molecular Function for SLC26A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005254 chloride channel activity IDA 1183472
GO:0005515 protein binding IPI 11278976
GO:0008271 secondary active sulfate transmembrane transporter activity IEA --
GO:0015116 sulfate transmembrane transporter activity IDA 1183472
GO:0015301 anion:anion antiporter activity IEA --
genes like me logo Genes that share ontologies with SLC26A8: view

Phenotypes for SLC26A8 Gene

genes like me logo Genes that share phenotypes with SLC26A8: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC26A8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC26A8 Gene

Localization for SLC26A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC26A8 Gene

Membrane; Multi-pass membrane protein. Note=Located at the annulus ring structure within the sperm cell. {ECO:0000269 PubMed:11278976, ECO:0000269 PubMed:17517695}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC26A8 Gene COMPARTMENTS Subcellular localization image for SLC26A8 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC26A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 11278976
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC26A8: view

Pathways for SLC26A8 Gene

genes like me logo Genes that share pathways with SLC26A8: view

Pathways by source for SLC26A8 Gene

1 PharmGKB pathway for SLC26A8 Gene

Gene Ontology (GO) - Biological Process for SLC26A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006820 anion transport IDA 11834742
GO:0006821 chloride transport IDA 1183472
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis --
GO:0008272 sulfate transport IDA 1183472
genes like me logo Genes that share ontologies with SLC26A8: view

Compounds for SLC26A8 Gene

(1) HMDB Compounds for SLC26A8 Gene

Compound Synonyms Cas Number PubMed IDs
Chlorine
  • Cl2
16887-00-6
genes like me logo Genes that share compounds with SLC26A8: view

Transcripts for SLC26A8 Gene

Unigene Clusters for SLC26A8 Gene

Solute carrier family 26, member 8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC26A8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^
SP1: - - -
SP2: - -
SP3: - - -
SP4: - -
SP5: - -
SP6: - -

ExUns: 19 ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for SLC26A8 Gene

GeneLoc Exon Structure for
SLC26A8
ECgene alternative splicing isoforms for
SLC26A8

Expression for SLC26A8 Gene

mRNA expression in normal human tissues for SLC26A8 Gene

mRNA differential expression in normal tissues according to GTEx for SLC26A8 Gene

This gene is overexpressed in Whole Blood (15.2) and Testis (14.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC26A8 Gene

SOURCE GeneReport for Unigene cluster for SLC26A8 Gene Hs.435836

mRNA Expression by UniProt/SwissProt for SLC26A8 Gene

Q96RN1-S26A8_HUMAN
Tissue specificity: Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell. Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids. Expressed in spermatozoa.
genes like me logo Genes that share expressions with SLC26A8: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC26A8 Gene

Orthologs for SLC26A8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC26A8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC26A8 35
  • 99.14 (n)
  • 98.66 (a)
SLC26A8 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC26A8 35
  • 78.2 (n)
  • 66.88 (a)
SLC26A8 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC26A8 35
  • 81.63 (n)
  • 73.28 (a)
SLC26A8 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc26a8 35
  • 74.62 (n)
  • 67.27 (a)
Slc26a8 16
Slc26a8 36
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC26A8 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC26A8 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc26a8 35
  • 74.71 (n)
  • 69.58 (a)
chicken
(Gallus gallus)
Aves SLC26A8 35
  • 55.04 (n)
  • 46.25 (a)
SLC26A8 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC26A8 36
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Prestin 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sulp-2 36
  • 24 (a)
ManyToMany
sulp-3 36
  • 21 (a)
ManyToMany
sulp-4 36
  • 22 (a)
ManyToMany
sulp-5 36
  • 22 (a)
ManyToMany
sulp-6 36
  • 21 (a)
ManyToMany
sulp-7 36
  • 25 (a)
ManyToMany
sulp-8 36
  • 25 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUL1 36
  • 16 (a)
ManyToMany
SUL2 36
  • 15 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToOne
Species with no ortholog for SLC26A8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC26A8 Gene

ENSEMBL:
Gene Tree for SLC26A8 (if available)
TreeFam:
Gene Tree for SLC26A8 (if available)

Paralogs for SLC26A8 Gene

Selected SIMAP similar genes for SLC26A8 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC26A8: view

Variants for SLC26A8 Gene

Sequence variations from dbSNP and Humsavar for SLC26A8 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs140723 -- 36,022,494(-) TATAT(-/CTGCATAT)CTGCA intron-variant
rs140728 -- 36,007,180(-) TTTAT(-/TT)CTTTT intron-variant
rs584884 -- 36,019,730(-) TATTT(G/T)CTCTC intron-variant
rs588024 -- 36,006,064(-) TTGAA(C/T)ATTAG intron-variant
rs596446 -- 36,001,418(-) gggcg(C/T)ggtgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC26A8 Gene

Variant ID Type Subtype PubMed ID
nsv528432 CNV Gain 19592680

Relevant External Links for SLC26A8 Gene

HapMap Linkage Disequilibrium report
SLC26A8
Human Gene Mutation Database (HGMD)
SLC26A8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC26A8 Gene

Disorders for SLC26A8 Gene

(1) OMIM Diseases for SLC26A8 Gene (608480)

UniProtKB/Swiss-Prot

S26A8_HUMAN
  • Spermatogenic failure 3 (SPGF3) [MIM:606766]: A disorder characterized by primary infertility, sperm morphologic abnormalities, and moderate to severe asthenozoospermia, condition in which the percentage of progressively motile sperm is abnormally low. {ECO:0000269 PubMed:23582645}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for SLC26A8 Gene

Relevant External Links for SLC26A8

Genetic Association Database (GAD)
SLC26A8
Human Genome Epidemiology (HuGE) Navigator
SLC26A8
genes like me logo Genes that share disorders with SLC26A8: view

Publications for SLC26A8 Gene

  1. Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling. (PMID: 11278976) Toure A. … Gacon G. (J. Biol. Chem. 2001) 3 4 23
  2. Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. (PMID: 11834742) Lohi H. … Kere J. (J. Biol. Chem. 2002) 2 3 4
  3. Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure. (PMID: 15579655) Makela S. … Kere J. (Mol. Hum. Reprod. 2005) 3 4 48
  4. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D. … Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 48
  5. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke M.M. … Psaty B.M. (Stroke 2009) 3 48

Products for SLC26A8 Gene

  • antibodies-online peptides for SLC26A8
  • antibodies-online antibodies for SLC26A8
  • antibodies-online kits for SLC26A8

Sources for SLC26A8 Gene

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