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SLC26A8 Gene

protein-coding   GIFtS: 56
GCID: GC06M035911

Solute Carrier Family 26 (Anion Exchanger), Member 8

(Previous names: solute carrier family 26, member 8)
  See SLC26A8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 26 (Anion Exchanger), Member 81 2     Anion Transporter/Exchanger-82
TAT12 3 5     Testis Anion Transporter 12
SPGF32 5     Anion Exchange Transporter3
Solute Carrier Family 26, Member 81     Solute Carrier Family 26 Member 83

External Ids:    HGNC: 144681   Entrez Gene: 1163692   Ensembl: ENSG000001120537   OMIM: 6084805   UniProtKB: Q96RN13   

Export aliases for SLC26A8 gene to outside databases

Previous GC identifers: GC06M035913 GC06M035958 GC06M036019 GC06M035631


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC26A8 Gene:
This gene encodes a member of the SLC26 gene family of anion transporters. Family members are well conserved in
gene structure and protein length yet have markedly different tissue expression patterns. The expression of this
gene appears to be restricted to spermatocytes. Alternatively spliced transcript variants that encode different
isoforms have been described. (provided by RefSeq, Jul 2010)

GeneCards Summary for SLC26A8 Gene:
SLC26A8 (solute carrier family 26 (anion exchanger), member 8) is a protein-coding gene. Diseases associated with SLC26A8 include spermatogenic failure 3, and spermatogenic failure. GO annotations related to this gene include anion:anion antiporter activity and chloride channel activity. An important paralog of this gene is SLC26A9.

UniProtKB/Swiss-Prot: S26A8_HUMAN, Q96RN1
Function: Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill
critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis.
May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells.
A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility
and hence male fertility. May form a moleculer complex involved in the regulation of chloride and bicarbonate
ions fluxes during sperm capacitation

Gene Wiki entry for SLC26A8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC26A8 gene promoter:
         MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC26A8 promoter sequence
   Search Chromatin IP Primers for SLC26A8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC26A8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21

SLC26A8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC26A8 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M035911:  view genomic region     (about GC identifiers)

Start:
35,911,291 bp from pter      End:
35,992,645 bp from pter
Size:
81,355 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: S26A8_HUMAN, Q96RN1 (See protein sequence)
Recommended Name: Testis anion transporter 1  
Size: 970 amino acids; 109006 Da
Subunit: Interacts with RACGAP1. Interacts with CFTR
Sequence caution: Sequence=AAO26699.1; Type=Miscellaneous discrepancy; Note=Incorrectly indicated as originating
from mouse; Sequence=BAB71408.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q5JVR5 Q812C7 Q8TC65 Q96MA0 Q96PK8
Alternative splicing: 4 isoforms:  Q96RN1-1   Q96RN1-2   Q96RN1-3   Q96RN1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC26A8: NX_Q96RN1

Explore proteomics data for SLC26A8 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn192

  • See SLC26A8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001180405.1  NP_443193.1  NP_619732.2  

    ENSEMBL proteins: 
     ENSP00000417638   ENSP00000378100   ENSP00000347778   ENSP00000418107   ENSP00000419700  
     ENSP00000420488  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Tat1
    Other SLC26 anion exchangers

    2 InterPro protein domains:
     IPR002645 STAS_dom
     IPR011547 Sulph_transpt

    Graphical View of Domain Structure for InterPro Entry Q96RN1

    ProtoNet protein and cluster: Q96RN1

    1 Blocks protein domain: IPB001902 Sulphate transporter

    UniProtKB/Swiss-Prot: S26A8_HUMAN, Q96RN1
    Similarity: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family
    Similarity: Contains 1 STAS domain


    Find genes that share domains with SLC26A8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S26A8_HUMAN, Q96RN1
    Function: Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill
    critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis.
    May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells.
    A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility
    and hence male fertility. May form a moleculer complex involved in the regulation of chloride and bicarbonate
    ions fluxes during sperm capacitation
    Enzyme regulation: Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an
    inhibitor of several anion channels and transporters), gluconate, and by thiosulfate
    Induction: Repressed by tunicamycin, an inhibitor of N-glycosylation

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005254chloride channel activity IDA1183472
    GO:0005515protein binding IPI11278976
    GO:0015116sulfate transmembrane transporter activity IDA1183472
    GO:0015301anion:anion antiporter activity IEA--
    GO:0019531oxalate transmembrane transporter activity IDA1183472
         
    Find genes that share ontologies with SLC26A8           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SLC26A8:
     Increased gamma-H2AX phosphory  Synthetic lethal with c-Myc af 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Slc26a8):
     reproductive system 

    Find genes that share phenotypes with SLC26A8           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SLC26A8

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S26A8_HUMAN, Q96RN1: Membrane; Multi-pass membrane protein. Note=Located at the annulus ring structure within the
    sperm cell
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol2
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA11278976
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLC26A8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC26A8 About    
    See pathways by source

    SuperPathContained pathways About
    1Tenofovir/Adefovir Pathway, Pharmacokinetics
    Tenofovir/Adefovir Pathway, Pharmacokinetics


    1 PharmGKB Pathway for SLC26A8
        Tenofovir/Adefovir Pathway, Pharmacokinetics

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC26A8
    Interactions:

        GeneGlobe Interaction Network for SLC26A8

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SLC26A8 (Q96RN11, 3 ENSP000003477784) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RACGAP1Q9H0H51, 3, ENSP000003098714EBI-1792052,EBI-717233 I2D: score=3 STRING: ENSP00000309871
    CFTRP135691, ENSP000000030844EBI-1792052,EBI-349854 STRING: ENSP00000003084
    NXF1ENSP000002941724STRING: ENSP00000294172
    NDUFAB1ENSP000000075164STRING: ENSP00000007516
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006820anion transport IDA11834742
    GO:0006821chloride transport IDA1183472
    GO:0007126meiotic nuclear division IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--

    Find genes that share ontologies with SLC26A8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SLC26A8 (S26A8)

    1 HMDB Compound for SLC26A8    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC26A8 gene (3 alternative transcripts): 
    NM_001193476.1  NM_052961.3  NM_138718.2  

    Unigene Cluster for SLC26A8:

    Solute carrier family 26, member 8
    Hs.435836  [show with all ESTs]
    Unigene Representative Sequence: NM_052961
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000490799(uc003oln.3) ENST00000466805(uc003olk.3) ENST00000394602(uc003oll.3)
    ENST00000355574(uc003olm.3) ENST00000465492(uc010jwa.3) ENST00000486155
    ENST00000469847 ENST00000480663
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    Additional mRNA sequence: 

    AF314959.1 AF331522.1 AK055314.1 AK057276.1 AK097410.1 AK122928.1 AK125189.1 BC025408.2 

    9 DOTS entries:

    DT.121316880  DT.97819435  DT.311221  DT.101975313  DT.97815157  DT.87046266  DT.452466  DT.95304984 
    DT.121316810 

    Selected AceView cDNA sequences (see all 35):

    AI203241 NM_138718 NM_052961 AK097410 AK057276 AK122928 CA390204 BC025408 
    BX115498 AA393555 AF331522 CD635418 BP371515 AK055314 AK125189 CD635415 
    AL705920 CD635413 CD635417 BE551631 AA626704 CD635416 AF314959 BE710125 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A8 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^
    SP1:                                      -     -                                                                                               -               
    SP2:                                            -                                                                                               -               
    SP3:                                                                                      -     -                                               -               
    SP4:                                      -     -                                                                                                               
    SP5:                                            -           -                                                                                                   

    ExUns: 19 ^ 20 ^ 21 ^ 22
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for SLC26A8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC26A8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTTCCTTC
    SLC26A8 Expression
    About this image

    SLC26A8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC26A8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435836

    UniProtKB/Swiss-Prot: S26A8_HUMAN, Q96RN1
    Tissue specificity: Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell.
    Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring
    the spermatocytes and spermatids. Expressed in spermatozoa

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC26A8 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc26a81 , 5 solute carrier family 26, member 81, 5 74.62(n)1
    67.27(a)1
      17 (14.82 cM)5
    2246611  XM_006525225.11  XP_006525288.11 
     286377835 
    chicken
    (Gallus gallus)
    Aves SLC26A81 solute carrier family 26, member 8 55.04(n)
    46.25(a)
      771137  XM_004934800.1  XP_004934857.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC26A86
    solute carrier family 26 (anion exchanger), member...
    44(a)
    1 ↔ 1
    4(114645428-114697945)
    fruit fly
    (Drosophila melanogaster)
    Insecta Prestin6
    Prestin
    22(a)
    1 → many
    3L(17891989-17900912)
    worm
    (Caenorhabditis elegans)
    Secernentea sulp-86
    sulp-76
    (see all 7)
    Protein SULP-8, isoform a (sulp-8) mRNA, complete ...
    Protein SULP-7, isoform c (sulp-7) mRNA, complete ...
    (see all 7)
    25(a)
    25(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    V(9670032-9673571) WBGene00013963
    X(11080678-11087474) WBGene00012259
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SUL16
    SUL26
    High affinity sulfate permease of the SulP anion t...
    High affinity sulfate permease; sulfate uptake is ...
    16(a)
    15(a)
    many ↔ many
    many ↔ many
    II(789235-791814) YBR294W
    XII(323544-326225) YLR092W


    ENSEMBL Gene Tree for SLC26A8 (if available)
    TreeFam Gene Tree for SLC26A8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC26A8 gene
    SLC26A92  SLC26A32  SLC26A62  SLC26A12  SLC26A52  SLC26A112  SLC26A22  SLC26A102  
    SLC26A72  SLC26A42  
    4 SIMAP similar genes for SLC26A8 using alignment to 4 protein entries:     S26A8_HUMAN (see all proteins):
    SLC26A4    SLC26A3    SLC26A6    SLC26A9

    Find genes that share paralogs with SLC26A8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC26A8 (see all 1830)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0700604
    Spermatogenic failure 3 (SPGF3)4--see VAR_0700602 R C mis40--------
    VAR_0700584
    Spermatogenic failure 3 (SPGF3)4--see VAR_0700582 R Q mis40--------
    VAR_0700594
    Spermatogenic failure 3 (SPGF3)4--see VAR_0700592 E K mis40--------
    rs1485090311,2
    C--35910819(+) TGGCT-/GGGGTCAC 3 -- cds10--------
    rs1431242601,2
    --35910873(+) GCCTAC/TATCTT 3 -- ds50010--------
    rs177061381,2
    C,F,H--35910874(+) CCTATA/GTCTTA 3 -- ds50018Minor allele frequency- G:0.02NA NS EA 558
    rs1821819631,2
    --35911049(+) AGGACC/GTGGTA 3 -- ds50010--------
    rs1414759011,2
    --35911402(+) GGGGTA/GTGTGA 3 -- ut310--------
    rs1858249221,2
    --35911586(+) CTAGTA/TCGTAT 3 -- ut310--------
    rs1910202291,2
    C--35911696(+) TGCTGC/TTGCCC 6 N S mis10--------

    HapMap Linkage Disequilibrium report for SLC26A8 (35911291 - 35992645 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SLC26A8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv528432CNV Gain19592680

    Human Gene Mutation Database (HGMD): SLC26A8
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC26A8
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC26A8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608480   
    OMIM disorders: 606766  
    UniProtKB/Swiss-Prot: S26A8_HUMAN, Q96RN1
  • Spermatogenic failure 3 (SPGF3) [MIM:606766]: A disorder characterized by primary infertility, sperm
    morphologic abnormalities, and moderate to severe asthenozoospermia, condition in which the percentage of
    progressively motile sperm is abnormally low. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 2 diseases for SLC26A8:    
    About MalaCards
    spermatogenic failure 3    spermatogenic failure

    1 disease from the University of Copenhagen DISEASES database for SLC26A8:
    Diastrophic dysplasia

    Find genes that share disorders with SLC26A8           About GenesLikeMe

    Genetic Association Database (GAD): SLC26A8
    Human Genome Epidemiology (HuGE) Navigator: SLC26A8 (8 documents)

    Export disorders for SLC26A8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC26A8 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with SLC26A8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure. (PubMed id 15579655)1, 2, 4 Makela S.... Kere J. (Mol. Hum. Reprod. 2005)
    2. Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. (PubMed id 11834742)1, 2, 3 Lohi H.... Kere J. (J. Biol. Chem. 2002)
    3. Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling. (PubMed id 11278976)1, 2, 9 Toure A.... Gacon G. (J. Biol. Chem. 2001)
    4. Missense mutations in SLC26A8, encoding a sperm-specific activator of CFTR, are associated with human asthenozoospermia. (PubMed id 23582645)1, 2 Dirami T....TourAc A. (Am. J. Hum. Genet. 2013)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. (PubMed id 19578796)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2009)
    8. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)
    9. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 116369 HGNC: 14468 AceView: SLC26A8 Ensembl:ENSG00000112053 euGenes: HUgn116369
    ECgene: SLC26A8 H-InvDB: SLC26A8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC26A8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC26A8 gene:
    Search GeneIP for patents involving SLC26A8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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