Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC26A8 Gene

protein-coding   GIFtS: 54
GCID: GC06M035911

solute carrier family 26, member 8

 Explore 17 diseases affiliated with
SLC26A8 via our new
 Human Malady Compendium 
Biological research products
for SLC26A8
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Solute Carrier Family 26, Member 81 2
Anion Exchange Transporter2 3
TAT12 3
Anion Transporter/Exchanger-82
Testis Anion Transporter 12
Solute Carrier Family 26 Member 83

External Ids:    HGNC: 144681   Entrez Gene: 1163692   Ensembl: ENSG000001120537   OMIM: 6084805   UniProtKB: Q96RN13   

Export aliases for SLC26A8 gene to outside databases

Previous GC identifers: GC06M035913 GC06M035958 GC06M036019 GC06M035631


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC26A8:
This gene encodes a member of the SLC26 gene family of anion transporters. Family members are well conserved in gene
structure and protein length yet have markedly different tissue expression patterns. The expression of this gene
appears to be restricted to spermatocytes. Alternatively spliced transcript variants that encode different isoforms
have been described. (provided by RefSeq, Jul 2010)

UniProtKB/Swiss-Prot: S26A8_HUMAN, Q96RN1
Function: Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill
critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May
be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A
critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and
hence male fertility

Gene Wiki entry for SLC26A8


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC26A8 gene promoter:
         MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC26A8 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC26A8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC26A8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21

SLC26A8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC26A8 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M035911:  view genomic region     (about GC identifiers)

Start:
35,911,291 bp from pter      End:
35,992,645 bp from pter
Size:
81,355 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S26A8_HUMAN, Q96RN1 (See protein sequence)
Recommended Name: Testis anion transporter 1  
Size: 970 amino acids; 109006 Da
Subunit: Interacts with RACGAP1
Subcellular location: Membrane; Multi-pass membrane protein. Note=Located at the annulus ring structure within the
sperm cell
Sequence caution: Sequence=AAO26699.1; Type=Miscellaneous discrepancy; Note=Incorrectly indicated as originating from
mouse; Sequence=BAB71408.1; Type=Erroneous initiation;
Secondary accessions: Q5JVR5 Q812C7 Q8TC65 Q96MA0 Q96PK8
Alternative splicing: 4 isoforms:  Q96RN1-1   Q96RN1-2   Q96RN1-3   Q96RN1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC26A8: NX_Q96RN1

Post-translational modifications:

  • N-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96RN1

  • SLC26A8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001180405.1  NP_443193.1  NP_619732.2  

    ENSEMBL proteins: 
     ENSP00000417638   ENSP00000378100   ENSP00000347778   ENSP00000418107   ENSP00000419700  
     ENSP00000420488  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for SLC26A8 
    GenScript Custom Purified and Recombinant Proteins Services for SLC26A8
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC26A8

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA11278976
    GO:0016021integral to membrane IEA--


    SLC26A8 for ontologies           About GeneDecksing



    SLC26A8 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: SLC26A8
    OriGene Custom Antibody Services for SLC26A8 
    GenScript Custom Superior Antibodies Services for SLC26A8
    Novus Biologicals SLC26A8 Antibodies
    Search for Antibodies for SLC26A8 at Abcam  
    Uscn Antibodies for SLC26A8
    ThermoFisher Antibodies for SLC26A8

    Assay Products for SLC26A8: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC26A8
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SLC26A8


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SLC26A8 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002645 STAS_dom
     IPR011547 Sulph_transpt

    Graphical View of Domain Structure for InterPro Entry Q96RN1

    ProtoNet protein and cluster: Q96RN1

    1 Blocks protein family: IPB001902 Sulphate transporter

    UniProtKB/Swiss-Prot: S26A8_HUMAN, Q96RN1
    Similarity: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family
    Similarity: Contains 1 STAS domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: S26A8_HUMAN, Q96RN1
    Function: Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill
    critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May
    be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A
    critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and
    hence male fertility
    Enzyme regulation: Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of
    several anion channels and transporters), gluconate, and by thiosulfate
    Induction: Repressed by tunicamycin, an inhibitor of N-glycosylation

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 2): SLC26A8
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC26A8
    1 QIAGEN miScript miRNA Assays for microRNA that regulate SLC26A8:
    hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidSLC26A8 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC26A8 (see all 7)
    OriGene shRNA RFP: SLC26A8
    OriGene siRNA: SLC26A8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC26A8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC26A8

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC26A8 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC26A8 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): SLC26A8 (NM_052961)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC26A8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC26A8 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC26A8
    Search LifeMap BioReagents cell lines for SLC26A8

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC26A8

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005254chloride channel activity IDA1183472
    GO:0005515protein binding IPI--
    GO:0015116sulfate transmembrane transporter activity IDA1183472
    GO:0015301anion:anion antiporter activity IEA--
    GO:0019531oxalate transmembrane transporter activity IDA1183472


    SLC26A8 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for SLC26A8:
     Increased gamma-H2AX phosphory  Synthetic lethal with c-Myc af 

    Animal Models:
         Mouse knock-out Slc26a8tm1Lex for SLC26A8
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc26a8):
     no phenotypic analysis  reproductive system 

    SLC26A8 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Tenofovir/Adefovir Pathway, Pharmacokinetics
    Tenofovir/Adefovir Pathway, Pharmacokinetics1.00


    1 PharmGKB Pathway for SLC26A8
        Tenofovir/Adefovir Pathway, Pharmacokinetics

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC26A8

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for SLC26A8 (Q96RN11, 3 ENSP000003477784) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RACGAP1Q9H0H51, 3, ENSP000003098714EBI-1792052,EBI-717233 I2D: score=3 STRING: ENSP00000309871
    CFTRP135691, ENSP000000030844EBI-1792052,EBI-349854 STRING: ENSP00000003084
    NXF1ENSP000002941724STRING: ENSP00000294172
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006821chloride transport IDA1183472
    GO:0007126meiosis IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0008272sulfate transport IDA1183472


    SLC26A8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC26A8

    1 HMDB Compound for SLC26A8    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    Search CenterWatch for drugs/clinical trials and news about SLC26A8 / S26A8 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC26A8 gene (3 alternative transcripts): 
    NM_001193476.1  NM_052961.3  NM_138718.2  

    Unigene Cluster for SLC26A8:

    Solute carrier family 26, member 8
    Hs.435836  [show with all ESTs]
    Unigene Representative Sequence: NM_052961
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000490799(uc003oln.3) ENST00000466805(uc003olk.3) ENST00000394602(uc003oll.3)
    ENST00000355574(uc003olm.3) ENST00000465492(uc010jwa.3) ENST00000486155
    ENST00000469847 ENST00000480663

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 2): SLC26A8
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC26A8
    1 QIAGEN miScript miRNA Assays for microRNA that regulate SLC26A8:
    hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidSLC26A8 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC26A8 (see all 7)
    OriGene shRNA RFP: SLC26A8
    OriGene siRNA: SLC26A8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC26A8
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC26A8 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC26A8 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): SLC26A8 (NM_052961)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC26A8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC26A8 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC26A8
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC26A8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC26A8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC26A8

    Additional cDNA sequence: 

    AF314959.1 AF331522.1 AK055314.1 AK057276.1 AK097410.1 AK122928.1 AK125189.1 BC025408.2 

    9 DOTS entries:

    DT.121316880  DT.97819435  DT.311221  DT.101975313  DT.97815157  DT.87046266  DT.452466  DT.95304984 
    DT.121316810 

    24/35 AceView cDNA sequences (see all 35):

    NM_138718 CD635418 AK097410 AF331522 CA390204 AK122928 BC025408 NM_052961 
    BX115498 AA393555 AK057276 AI203241 AA626704 BE551631 BP371515 AK125189 
    CD635417 BE710125 AF314959 CD635414 AK055314 CD635416 AI015633 CD635415 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A8 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^
    SP1:                                      -     -                                                                                               -               
    SP2:                                            -                                                                                               -               
    SP3:                                                                                      -     -                                               -               
    SP4:                                      -     -                                                                                                               
    SP5:                                            -           -                                                                                                   

    ExUns: 19 ^ 20 ^ 21 ^ 22
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for SLC26A8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC26A8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATTTCCTTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SLC26A8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC26A8

    SOURCE GeneReport for Unigene cluster: Hs.435836

    UniProtKB/Swiss-Prot: S26A8_HUMAN, Q96RN1
    Tissue specificity: Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell.
    Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the
    spermatocytes and spermatids. Expressed in spermatozoa

        SABiosciences Custom PCR Arrays for SLC26A8
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC26A8
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC26A8
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC26A8
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC26A8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC26A8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLC26A8 gene from 4/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SLC26A86
    Uncharacterized protein
    44(a)
    1 ↔ 1
    26(121000-134800)
    lizard
    (Anolis carolinensis)
    Reptilia SLC26A86
    --
    43(a)
    1 ↔ 1
    4(114646251-114697945)
    fruit fly
    (Drosophila melanogaster)
    Insecta Prestin6
    Prestin
    20(a)
    possible ortholog
    3L(17891989-17900912)
    worm
    (Caenorhabditis elegans)
    Secernentea sulp-86
    sulp-76
    (see all 8)
    SULfate Permease family member (sulp-7)
    (see all 8)
    25(a)
    23(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    V(9670008-9673547)
    X(11080612-11087408)


    ENSEMBL Gene Tree for SLC26A8 (if available)
    TreeFam Gene Tree for SLC26A8 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC26A8 gene
    SLC26A92  SLC26A32  SLC26A102  SLC26A72  SLC26A62  SLC26A42  SLC26A12  SLC26A52  
    SLC26A22  SLC26A112  
    4 SIMAP similar genes for SLC26A8 using alignment to 4 protein entries:     S26A8_HUMAN (see all proteins):
    SLC26A4    SLC26A3    SLC26A6    SLC26A9

    SLC26A8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1495 NCBI SNPs in SLC26A8 are shown (see all 1495    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1485090311,2
    C,--35910819(+) TGGCT-/GGGGTCAC 3 -- ds50010--------
    rs1431242601,2
    --35910873(+) GCCTAC/TATCTT 3 -- ds50010--------
    rs177061381,2
    C,F,H,--35910874(+) CCTATA/GTCTTA 3 -- ds50018Minor allele frequency- G:0.02NA NS EA 558
    rs1821819631,2
    --35911049(+) AGGACC/GTGGTA 3 -- ds50010--------
    rs1414759011,2
    --35911402(+) GGGGTA/GTGTGA 3 -- ut310--------
    rs1858249221,2
    --35911586(+) CTAGTA/TCGTAT 3 -- ut310--------
    rs1910202291,2
    C,--35911696(+) TGCTGC/TTGCCC 6 N S mis10--------
    rs2012395171,2
    --35911752(+) CATGTC/TCGAGT 6 R syn10--------
    rs2002640811,2
    --35911768(+) TCTGAC/GACTGG 6 S C mis10--------
    rs1456172321,2
    C,F--35911783(+) AAGCCA/TTAGAC 6 K M mis11Minor allele frequency- T:0.00NA 4552

    HapMap Linkage Disequilibrium report for SLC26A8 (35911291 - 35992645 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLC26A8: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC26A8
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC26A8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SLC26A8 for disorders           About GeneDecksing

    OMIM gene information: 608480    OMIM disorders: --

    17 diseases for SLC26A8:    About MalaCards
    ventricular septal defect    congenital dyserythropoietic anemia    diastrophic dysplasia    dyserythropoietic anemia
    male infertility    fainting    infertility    pharyngitis
    anemia    hypertension    schizophrenia    tuberculosis
    malaria    neuronitis    spermatogenic failure    mycobacterium tuberculosis
    immunodeficiency

    2 diseases from the University of Copenhagen DISEASES database for SLC26A8:
    Diastrophic dysplasia     Congenital dyserythropoietic anemia
    Genetic Association Database (GAD): SLC26A8
    Human Genome Epidemiology (HuGE) Navigator: SLC26A8 (8 documents)

    Export disorders for SLC26A8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC26A8 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with SLC26A8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure. (PubMed id 15579655)1, 2, 4 Makela S.... Kere J. (2005)
    2. Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. (PubMed id 11834742)1, 2, 3 Lohi H.... Kere J. (2002)
    3. Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling. (PubMed id 11278976)1, 2, 9 Toure A.... Gacon G. (2001)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney. (PubMed id 11829495)1, 3 Vincourt J.-B.... Girard J.-P. (2002)
    6. The testis anion transporter 1 (Slc26a8) is required for sperm terminal differentiation and male fertility in the mouse. (PubMed id 17517695)2, 9 Toure A.... Gacon G. (2007)
    7. Absence of annulus in human asthenozoospermia: case report. (PubMed id 19221096)1, 9 Lhuillier P....TourAc A. (2009)
    8. Exome sequencing supports a de novo mutational paradi gm for schizophrenia. (PubMed id 21822266)1 Xu B....Karayiorgou M. (2011)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 116369 HGNC: 14468 AceView: SLC26A8 Ensembl:ENSG00000112053 euGenes: HUgn116369
    ECgene: SLC26A8 H-InvDB: SLC26A8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC26A8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC26A8 gene:
    Search GeneIP for patents involving SLC26A8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for SLC26A8   OriGene shRNA RFP for SLC26A8  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC26A8   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC26A8  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SLC26A8   OriGene 3'-UTR Clone for SLC26A8  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC26A8   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC26A8  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC26A8   OriGene Custom Protein Services for SLC26A8  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC26A8
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC26A8
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC26A8
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC26A8
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC26A8
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC26A8
     GenScript Custom Purified and Recombinant Proteins Services for SLC26A8 GenScript cDNA clones with any tag delivered in your preferred vector for SLC26A8
     GenScript Custom Assay Services for SLC26A8 GenScript Custom Superior Antibodies Services for SLC26A8
     GenScript Custom overexpressing Cell Line Services for SLC26A8 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SLC26A8 promoter
     Search Chromatin IP Primers for SLC26A8
     RT2 qPCR Primer Assay in human, mouse, rat SLC26A8
     GNC Network for SLC26A8
     SABiosciences Custom PCR Arrays for SLC26A8
     Search Tocris compounds for SLC26A8
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SLC26A8 antibodies
     Search for Antibodies for SLC26A8 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SLC26A8
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SLC26A8 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SLC26A8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC26A8
     SwitchGear 3'UTR luciferase reporter plasmids for SLC26A8
     SwitchGear Promoter luciferase reporter plasmids for SLC26A8
     ThermoFisher Antibodies for SLC26A8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC26A8
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC26A8 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4