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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC26A8 Gene

protein-coding   GIFtS: 57
GCID: GC06M035911

Solute Carrier Family 26 (Anion Exchanger), Member 8

(Previous names: solute carrier family 26, member 8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 26 (Anion Exchanger), Member 81 2     SPGF32
Solute Carrier Family 26, Member 81 2     Anion Transporter/Exchanger-82
Anion Exchange Transporter2 3     Testis Anion Transporter 12
TAT12 3     Solute Carrier Family 26 Member 83

External Ids:    HGNC: 144681   Entrez Gene: 1163692   Ensembl: ENSG000001120537   OMIM: 6084805   UniProtKB: Q96RN13   

Export aliases for SLC26A8 gene to outside databases

Previous GC identifers: GC06M035913 GC06M035958 GC06M036019 GC06M035631


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC26A8 Gene:
This gene encodes a member of the SLC26 gene family of anion transporters. Family members are well conserved in
gene structure and protein length yet have markedly different tissue expression patterns. The expression of this
gene appears to be restricted to spermatocytes. Alternatively spliced transcript variants that encode different
isoforms have been described. (provided by RefSeq, Jul 2010)

GeneCards Summary for SLC26A8 Gene: 
SLC26A8 (solute carrier family 26 (anion exchanger), member 8) is a protein-coding gene. Diseases associated with SLC26A8 include ventricular septal defect, and diastrophic dysplasia. GO annotations related to this gene include anion:anion antiporter activity and chloride channel activity. An important paralog of this gene is SLC26A9.

UniProtKB/Swiss-Prot: S26A8_HUMAN, Q96RN1
Function: Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill
critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis.
May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells.
A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility
and hence male fertility

Gene Wiki entry for SLC26A8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC26A8 gene promoter:
         MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC26A8 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC26A8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC26A8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21

SLC26A8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC26A8 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M035911:  view genomic region     (about GC identifiers)

Start:
35,911,291 bp from pter      End:
35,992,645 bp from pter
Size:
81,355 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S26A8_HUMAN, Q96RN1 (See protein sequence)
Recommended Name: Testis anion transporter 1  
Size: 970 amino acids; 109006 Da
Subunit: Interacts with RACGAP1
Subcellular location: Membrane; Multi-pass membrane protein. Note=Located at the annulus ring structure within the
sperm cell
Sequence caution: Sequence=AAO26699.1; Type=Miscellaneous discrepancy; Note=Incorrectly indicated as originating
from mouse; Sequence=BAB71408.1; Type=Erroneous initiation;
Secondary accessions: Q5JVR5 Q812C7 Q8TC65 Q96MA0 Q96PK8
Alternative splicing: 4 isoforms:  Q96RN1-1   Q96RN1-2   Q96RN1-3   Q96RN1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC26A8: NX_Q96RN1

Explore proteomics data for SLC26A8 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96RN1

  • SLC26A8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC26A8 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001180405.1  NP_443193.1  NP_619732.2  

    ENSEMBL proteins: 
     ENSP00000417638   ENSP00000378100   ENSP00000347778   ENSP00000418107   ENSP00000419700  
     ENSP00000420488  

    Human Recombinant Protein Products for SLC26A8: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA11278976
    GO:0016021integral to membrane IEA--

    SLC26A8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Tat1 
    Other SLC26 anion exchangers

    2 InterPro protein domains:
     IPR002645 STAS_dom
     IPR011547 Sulph_transpt

    Graphical View of Domain Structure for InterPro Entry Q96RN1

    ProtoNet protein and cluster: Q96RN1

    1 Blocks protein domain: IPB001902 Sulphate transporter

    UniProtKB/Swiss-Prot: S26A8_HUMAN, Q96RN1
    Similarity: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family
    Similarity: Contains 1 STAS domain


    SLC26A8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S26A8_HUMAN, Q96RN1
    Function: Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill
    critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis.
    May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells.
    A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility
    and hence male fertility
    Enzyme regulation: Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an
    inhibitor of several anion channels and transporters), gluconate, and by thiosulfate
    Induction: Repressed by tunicamycin, an inhibitor of N-glycosylation

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005254chloride channel activity IDA1183472
    GO:0005515protein binding IPI11278976
    GO:0015116sulfate transmembrane transporter activity IDA1183472
    GO:0015301anion:anion antiporter activity IEA--
    GO:0019531oxalate transmembrane transporter activity IDA1183472
         
    SLC26A8 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SLC26A8:
     Increased gamma-H2AX phosphory  Synthetic lethal with c-Myc af 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Slc26a8):
     reproductive system 

    SLC26A8 for phenotypes           About GeneDecksing

    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC26A8 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Tenofovir/Adefovir Pathway, Pharmacokinetics
    Tenofovir/Adefovir Pathway, Pharmacokinetics


    1 PharmGKB Pathway for SLC26A8
        Tenofovir/Adefovir Pathway, Pharmacokinetics

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC26A8

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for SLC26A8 (Q96RN11, 3 ENSP000003477784) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RACGAP1Q9H0H51, 3, ENSP000003098714EBI-1792052,EBI-717233 I2D: score=3 STRING: ENSP00000309871
    CFTRP135691, ENSP000000030844EBI-1792052,EBI-349854 STRING: ENSP00000003084
    NXF1ENSP000002941724STRING: ENSP00000294172
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006820anion transport IDA11834742
    GO:0006821chloride transport IDA1183472
    GO:0007126meiosis IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--

    SLC26A8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC26A8 (S26A8)

    1 HMDB Compound for SLC26A8    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--

    Search CenterWatch for drugs/clinical trials and news about SLC26A8 / S26A8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC26A8 gene (3 alternative transcripts): 
    NM_001193476.1  NM_052961.3  NM_138718.2  

    Unigene Cluster for SLC26A8:

    Solute carrier family 26, member 8
    Hs.435836  [show with all ESTs]
    Unigene Representative Sequence: NM_052961
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000490799(uc003oln.3) ENST00000466805(uc003olk.3) ENST00000394602(uc003oll.3)
    ENST00000355574(uc003olm.3) ENST00000465492(uc010jwa.3) ENST00000486155
    ENST00000469847 ENST00000480663
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate SLC26A8:
    hsa-miR-9
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF314959.1 AF331522.1 AK055314.1 AK057276.1 AK097410.1 AK122928.1 AK125189.1 BC025408.2 

    9 DOTS entries:

    DT.121316880  DT.97819435  DT.311221  DT.101975313  DT.97815157  DT.87046266  DT.452466  DT.95304984 
    DT.121316810 

    24/35 AceView cDNA sequences (see all 35):

    AI203241 NM_052961 NM_138718 CA390204 BC025408 AA393555 AF331522 AK122928 
    BX115498 AK057276 CD635418 AK097410 CD635413 BE710125 CD635416 BP371515 
    CD635415 AA626704 AL705920 BE551631 CD635414 AK055314 AK125189 AI015633 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A8 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^
    SP1:                                      -     -                                                                                               -               
    SP2:                                            -                                                                                               -               
    SP3:                                                                                      -     -                                               -               
    SP4:                                      -     -                                                                                                               
    SP5:                                            -           -                                                                                                   

    ExUns: 19 ^ 20 ^ 21 ^ 22
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for SLC26A8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC26A8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTTCCTTC
    SLC26A8 Expression
    About this image


    See SLC26A8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC26A8

    SOURCE GeneReport for Unigene cluster: Hs.435836

    UniProtKB/Swiss-Prot: S26A8_HUMAN, Q96RN1
    Tissue specificity: Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell.
    Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring
    the spermatocytes and spermatids. Expressed in spermatozoa

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC26A8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC26A8 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc26a81 , 5 solute carrier family 26, member 81, 5 75.69(n)1
    68.37(a)1
      17 (14.82 cM)5
    2246611  XM_003085148.11  XP_003085196.11 
     286377835 
    chicken
    (Gallus gallus)
    Aves SLC26A86
    Uncharacterized protein
    42(a)
    1 ↔ 1
    26(115691-132613)
    lizard
    (Anolis carolinensis)
    Reptilia SLC26A86
    Uncharacterized protein
    44(a)
    1 ↔ 1
    4(114645428-114697945)
    fruit fly
    (Drosophila melanogaster)
    Insecta Prestin6
    Prestin
    20(a)
    1 → many
    3L(17891989-17900912)
    worm
    (Caenorhabditis elegans)
    Secernentea sulp-86
    sulp-76
    (see all 8)
    Protein SULP-7, isoform d
    (see all 8)
    25(a)
    24(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    V(9670032-9673571)
    X(11080678-11087474)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SUL16
    SUL26
    High affinity sulfate permease of the SulP anion t...
    High affinity sulfate permease; sulfate uptake is ...
    16(a)
    14(a)
    many ↔ many
    many ↔ many
    II(789235-791814)
    XII(323544-326225)


    ENSEMBL Gene Tree for SLC26A8 (if available)
    TreeFam Gene Tree for SLC26A8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC26A8 gene
    SLC26A92  SLC26A32  SLC26A62  SLC26A12  SLC26A52  SLC26A112  SLC26A22  SLC26A102  
    SLC26A72  SLC26A42  
    4 SIMAP similar genes for SLC26A8 using alignment to 4 protein entries:     S26A8_HUMAN (see all proteins):
    SLC26A4    SLC26A3    SLC26A6    SLC26A9

    SLC26A8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1827 SNPs in SLC26A8 are shown (see all 1827)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1485090311,2
    C--35910819(+) TGGCT-/GGGGTCAC 3 -- cds10--------
    rs1431242601,2
    --35910873(+) GCCTAC/TATCTT 3 -- ds50010--------
    rs177061381,2
    C,F,H--35910874(+) CCTATA/GTCTTA 3 -- ds50018Minor allele frequency- G:0.02NA NS EA 558
    rs1821819631,2
    --35911049(+) AGGACC/GTGGTA 3 -- ds50010--------
    rs1414759011,2
    --35911402(+) GGGGTA/GTGTGA 3 -- ut310--------
    rs1858249221,2
    --35911586(+) CTAGTA/TCGTAT 3 -- ut310--------
    rs1910202291,2
    C--35911696(+) TGCTGC/TTGCCC 6 N S mis10--------
    rs2012395171,2
    --35911752(+) CATGTC/TCGAGT 6 R syn10--------
    rs2015475541,2
    C--35911754(+) TGTCCA/GAGTCT 6 R W mis10--------
    rs2002640811,2
    --35911768(+) TCTGAC/GACTGG 6 S C mis10--------

    HapMap Linkage Disequilibrium report for SLC26A8 (35911291 - 35992645 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SLC26A8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv528432CNV Gain19592680


    Human Gene Mutation Database (HGMD): SLC26A8
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC26A8
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC26A8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608480    OMIM disorders: --

    12 diseases for SLC26A8:    About MalaCards
    ventricular septal defect    diastrophic dysplasia    congenital dyserythropoietic anemia    fainting
    male infertility    infertility    anemia    myocardial infarction
    hypertension    schizophrenia    tuberculosis    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for SLC26A8:
    Diastrophic dysplasia

    SLC26A8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC26A8
    Human Genome Epidemiology (HuGE) Navigator: SLC26A8 (8 documents)

    Export disorders for SLC26A8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC26A8 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with SLC26A8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure. (PubMed id 15579655)1, 2, 4 Makela S.... Kere J. (2005)
    2. Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. (PubMed id 11834742)1, 2, 3 Lohi H.... Kere J. (2002)
    3. Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling. (PubMed id 11278976)1, 2, 9 Toure A.... Gacon G. (2001)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. Association of genetic variants with chronic kidney d isease in individuals with different lipid profiles. (PubMed id 19578796)1, 4 Yoshida T....Yamada Y. (2009)
    7. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. (2009)
    8. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (2008)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney. (PubMed id 11829495)1, 3 Vincourt J.-B.... Girard J.-P. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 116369 HGNC: 14468 AceView: SLC26A8 Ensembl:ENSG00000112053 euGenes: HUgn116369
    ECgene: SLC26A8 H-InvDB: SLC26A8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC26A8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC26A8 gene:
    Search GeneIP for patents involving SLC26A8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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