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Aliases for SLC26A7 Gene

Aliases for SLC26A7 Gene

  • Solute Carrier Family 26 Member 7 2 3 4 5
  • Solute Carrier Family 26 (Anion Exchanger), Member 7 2 3
  • Anion Exchange Transporter 2 3
  • SUT2 3 4
  • Solute Carrier Family 26, Member 7 2
  • Sulfate Anion Transporter 3

External Ids for SLC26A7 Gene

Previous GeneCards Identifiers for SLC26A7 Gene

  • GC08P090739
  • GC08P092107
  • GC08P091930
  • GC08P092218
  • GC08P092330
  • GC08P087472
  • GC08P092221

Summaries for SLC26A7 Gene

Entrez Gene Summary for SLC26A7 Gene

  • This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. This gene has abundant and specific expression in the kidney. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Aug 2013]

GeneCards Summary for SLC26A7 Gene

SLC26A7 (Solute Carrier Family 26 Member 7) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Salivary secretion. GO annotations related to this gene include chloride channel activity and sulfate transmembrane transporter activity. An important paralog of this gene is SLC26A3.

UniProtKB/Swiss-Prot for SLC26A7 Gene

  • Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion.

Gene Wiki entry for SLC26A7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC26A7 Gene

Genomics for SLC26A7 Gene

Regulatory Elements for SLC26A7 Gene

Enhancers for SLC26A7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G091179 1 Ensembl ENCODE 18.3 -29.0 -29040 1.3 ZNF639 JUN MAX ZNF175 SIN3A CEBPB CEBPG EP300 FOSL1 ZNF589 SLC26A7 LRRC69 GC08P091158 MIR4661
GH08G091068 1.1 ENCODE 8.7 -139.5 -139456 2.7 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 OTUD6B-AS1 SLC26A7 LOC102724670 LRRC69 ENSG00000254219
GH08G091039 1.1 ENCODE 7.8 -169.4 -169350 4.3 ARID4B SIN3A ZNF2 FOS ZNF263 SP3 SP5 REST SMARCB1 KAT8 OTUD6B-AS1 SLC26A7 LRRC69 LOC105375634 TMEM55A ENSG00000253358
GH08G090858 1.1 ENCODE dbSUPER 6.2 -349.8 -349807 3.2 HDGF PKNOX1 NFIB SIN3A ZNF207 FOS RCOR1 ZNF843 ZNF592 ZNF217 LOC105375634 SLC26A7 C8orf88 LOC105375635
GH08G091344 0.4 FANTOM5 16.3 +134.7 134712 0.1 CREB1 SLC26A7 LOC105375637 GC08P091595
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC26A7 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC26A7 Gene

Chromosome:
8
Start:
91,209,494 bp from pter
End:
91,398,155 bp from pter
Size:
188,662 bases
Orientation:
Plus strand

Genomic View for SLC26A7 Gene

Genes around SLC26A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC26A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC26A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC26A7 Gene

Proteins for SLC26A7 Gene

  • Protein details for SLC26A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE54-S26A7_HUMAN
    Recommended name:
    Anion exchange transporter
    Protein Accession:
    Q8TE54
    Secondary Accessions:
    • Q24JS8
    • Q8TE53
    • Q96RN2

    Protein attributes for SLC26A7 Gene

    Size:
    656 amino acids
    Molecular mass:
    72213 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Is active at both alkaline and acidic pH. Activity is inhibited by 4,4-Di-isothiocyanatostilbene-2,2-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters).

    Alternative splice isoforms for SLC26A7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC26A7 Gene

Post-translational modifications for SLC26A7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC26A7 Gene

Domains & Families for SLC26A7 Gene

Gene Families for SLC26A7 Gene

Protein Domains for SLC26A7 Gene

Suggested Antigen Peptide Sequences for SLC26A7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TE54

UniProtKB/Swiss-Prot:

S26A7_HUMAN :
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Family:
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
genes like me logo Genes that share domains with SLC26A7: view

Function for SLC26A7 Gene

Molecular function for SLC26A7 Gene

UniProtKB/Swiss-Prot Function:
Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion.

Gene Ontology (GO) - Molecular Function for SLC26A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005253 anion channel activity IEA --
GO:0005254 chloride channel activity TAS --
GO:0008271 secondary active sulfate transmembrane transporter activity IEA --
GO:0008509 anion transmembrane transporter activity IEA --
GO:0015106 bicarbonate transmembrane transporter activity ISS 12736153
genes like me logo Genes that share ontologies with SLC26A7: view
genes like me logo Genes that share phenotypes with SLC26A7: view

Animal Models for SLC26A7 Gene

MGI Knock Outs for SLC26A7:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC26A7

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC26A7 Gene

Localization for SLC26A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC26A7 Gene

Recycling endosome membrane; Multi-pass membrane protein. Note=Expressed in the cytoplasm in recycling endosomes of medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion. {ECO:0000269 PubMed:16524946}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC26A7 gene
Compartment Confidence
plasma membrane 5
endosome 5

Gene Ontology (GO) - Cellular Components for SLC26A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16524946
GO:0005768 endosome IEA,IDA 16524946
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC26A7: view

Pathways & Interactions for SLC26A7 Gene

genes like me logo Genes that share pathways with SLC26A7: view

Gene Ontology (GO) - Biological Process for SLC26A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001696 gastric acid secretion IEA --
GO:0006810 transport IEA --
GO:0006811 ion transport TAS --
GO:0006820 anion transport IDA 11834742
GO:0006821 chloride transport IDA 1183472
genes like me logo Genes that share ontologies with SLC26A7: view

No data available for SIGNOR curated interactions for SLC26A7 Gene

Drugs & Compounds for SLC26A7 Gene

(3) Additional Compounds for SLC26A7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
Hydrogen carbonate
  • Bicarbonate
  • Bicarbonate (HCO3-)
  • Bicarbonate anion
  • Bicarbonate ion
  • Bicarbonate ion (HCO31-)
71-52-3
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC26A7: view

Transcripts for SLC26A7 Gene

Unigene Clusters for SLC26A7 Gene

Solute carrier family 26, member 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A7 Gene

No ASD Table

Relevant External Links for SLC26A7 Gene

GeneLoc Exon Structure for
SLC26A7
ECgene alternative splicing isoforms for
SLC26A7

Expression for SLC26A7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC26A7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC26A7 Gene

This gene is overexpressed in Thyroid (x46.5).

Protein differential expression in normal tissues from HIPED for SLC26A7 Gene

This gene is overexpressed in Thyroid (58.3) and Adipocyte (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC26A7 Gene



Protein tissue co-expression partners for SLC26A7 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC26A7 Gene:

SLC26A7

SOURCE GeneReport for Unigene cluster for SLC26A7 Gene:

Hs.354013

mRNA Expression by UniProt/SwissProt for SLC26A7 Gene:

Q8TE54-S26A7_HUMAN
Tissue specificity: Expressed in tonsillar high endothelial venule endothelial cells (HEVEC), placenta and in testis, expressed in a subgroup of basal cells in the epididymal ducts.

Evidence on tissue expression from TISSUES for SLC26A7 Gene

  • Kidney(2.4)
  • Thyroid gland(2.3)
genes like me logo Genes that share expression patterns with SLC26A7: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC26A7 Gene

Orthologs for SLC26A7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC26A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC26A7 34 35
  • 98.95 (n)
dog
(Canis familiaris)
Mammalia SLC26A7 34 35
  • 90.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC26A7 35
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC26A7 34 35
  • 88.19 (n)
mouse
(Mus musculus)
Mammalia Slc26a7 34 16 35
  • 86.99 (n)
rat
(Rattus norvegicus)
Mammalia Slc26a7 34
  • 84.64 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC26A7 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC26A7 34 35
  • 73.38 (n)
lizard
(Anolis carolinensis)
Reptilia SLC26A7 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc26a7 34
  • 62.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta Prestin 35
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea W04G3.6 36
  • 34 (a)
K12G11.2 36
  • 31 (a)
W01B11.2 36
  • 29 (a)
sulp-7 35
  • 29 (a)
ManyToMany
F41D9.5 36
  • 28 (a)
ZK287.2 36
  • 28 (a)
F14D12.5 36
  • 27 (a)
sulp-8 35
  • 27 (a)
ManyToMany
sulp-5 35
  • 26 (a)
ManyToMany
sulp-2 35
  • 25 (a)
ManyToMany
sulp-4 35
  • 25 (a)
ManyToMany
sulp-3 35
  • 23 (a)
ManyToMany
sulp-6 35
  • 22 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUL1 35
  • 13 (a)
ManyToMany
SUL2 35
  • 12 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
OneToMany
Species where no ortholog for SLC26A7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC26A7 Gene

ENSEMBL:
Gene Tree for SLC26A7 (if available)
TreeFam:
Gene Tree for SLC26A7 (if available)

Paralogs for SLC26A7 Gene

(10) SIMAP similar genes for SLC26A7 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC26A7: view

Variants for SLC26A7 Gene

Sequence variations from dbSNP and Humsavar for SLC26A7 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000042955 -- 91,313,382(+) TATAG(C/T)TTTTT intron-variant
rs1000074172 -- 91,313,022(+) TTTGG(C/T)GCCCA intron-variant
rs1000096778 -- 91,214,661(+) TCTTC(C/T)AGCAT intron-variant
rs1000101050 -- 91,322,995(+) AAACA(G/T)TTTCT intron-variant
rs1000105490 -- 91,356,943(+) TTCTT(A/G)TTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC26A7 Gene

Variant ID Type Subtype PubMed ID
esv2759629 CNV loss 17122850
esv3364482 CNV insertion 20981092
esv3559664 CNV deletion 23714750
esv3618020 CNV loss 21293372
esv3618021 CNV loss 21293372
esv3618022 CNV gain 21293372
nsv1132157 CNV deletion 24896259
nsv1132158 CNV deletion 24896259
nsv523642 CNV gain 19592680
nsv6302 CNV deletion 18451855

Variation tolerance for SLC26A7 Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.36; 53.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC26A7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC26A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC26A7 Gene

Disorders for SLC26A7 Gene

Relevant External Links for SLC26A7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC26A7

No disorders were found for SLC26A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC26A7 Gene

Publications for SLC26A7 Gene

  1. Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney. (PMID: 11829495) Vincourt J.-B. … Girard J.-P. (Genomics 2002) 2 3 4 22 64
  2. Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion. (PMID: 16524946) Xu J. … Soleimani M. (J. Am. Soc. Nephrol. 2006) 2 3 4 64
  3. Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. (PMID: 11834742) Lohi H. … Kere J. (J. Biol. Chem. 2002) 2 3 4 64
  4. SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney. (PMID: 15956810) Kujala M. … Kere J. (Nephron Exp. Nephrol. 2005) 3 4 64
  5. Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells. (PMID: 12736153) Petrovic S. … Soleimani M. (Am. J. Physiol. 2003) 3 4 64

Products for SLC26A7 Gene

Sources for SLC26A7 Gene

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