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Aliases for SLC26A7 Gene

Aliases for SLC26A7 Gene

  • Solute Carrier Family 26 Member 7 2 3 4
  • Solute Carrier Family 26 (Anion Exchanger), Member 7 2 3 5
  • Solute Carrier Family 26, Member 7 2 3
  • SUT2 3 4
  • Sulfate Anion Transporter 3

External Ids for SLC26A7 Gene

Previous GeneCards Identifiers for SLC26A7 Gene

  • GC08P090739
  • GC08P092107
  • GC08P091930
  • GC08P092218
  • GC08P092330
  • GC08P087472
  • GC08P092221

Summaries for SLC26A7 Gene

Entrez Gene Summary for SLC26A7 Gene

  • This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. This gene has abundant and specific expression in the kidney. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Aug 2013]

GeneCards Summary for SLC26A7 Gene

SLC26A7 (Solute Carrier Family 26 Member 7) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Salivary secretion. GO annotations related to this gene include chloride channel activity and sulfate transmembrane transporter activity. An important paralog of this gene is SLC26A2.

UniProtKB/Swiss-Prot for SLC26A7 Gene

  • Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion.

Gene Wiki entry for SLC26A7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC26A7 Gene

Genomics for SLC26A7 Gene

Regulatory Elements for SLC26A7 Gene

Genomic Location for SLC26A7 Gene

Chromosome:
8
Start:
91,209,494 bp from pter
End:
91,398,155 bp from pter
Size:
188,662 bases
Orientation:
Plus strand

Genomic View for SLC26A7 Gene

Genes around SLC26A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC26A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC26A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC26A7 Gene

Proteins for SLC26A7 Gene

  • Protein details for SLC26A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE54-S26A7_HUMAN
    Recommended name:
    Anion exchange transporter
    Protein Accession:
    Q8TE54
    Secondary Accessions:
    • Q24JS8
    • Q8TE53
    • Q96RN2

    Protein attributes for SLC26A7 Gene

    Size:
    656 amino acids
    Molecular mass:
    72213 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Is active at both alkaline and acidic pH. Activity is inhibited by 4,4-Di-isothiocyanatostilbene-2,2-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters).

    Alternative splice isoforms for SLC26A7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC26A7 Gene

Proteomics data for SLC26A7 Gene at MOPED

Post-translational modifications for SLC26A7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC26A7 Gene

Domains & Families for SLC26A7 Gene

Gene Families for SLC26A7 Gene

Protein Domains for SLC26A7 Gene

Suggested Antigen Peptide Sequences for SLC26A7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TE54

UniProtKB/Swiss-Prot:

S26A7_HUMAN :
  • Contains 1 STAS domain.
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Domain:
  • Contains 1 STAS domain.
Family:
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
genes like me logo Genes that share domains with SLC26A7: view

Function for SLC26A7 Gene

Molecular function for SLC26A7 Gene

UniProtKB/Swiss-Prot Function:
Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion.

Gene Ontology (GO) - Molecular Function for SLC26A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019531 oxalate transmembrane transporter activity IDA 1183472
genes like me logo Genes that share ontologies with SLC26A7: view
genes like me logo Genes that share phenotypes with SLC26A7: view

Animal Models for SLC26A7 Gene

MGI Knock Outs for SLC26A7:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC26A7

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC26A7 Gene

Localization for SLC26A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC26A7 Gene

Recycling endosome membrane; Multi-pass membrane protein. Note=Expressed in the cytoplasm in recycling endosomes of medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion. {ECO:0000269 PubMed:16524946}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC26A7 Gene COMPARTMENTS Subcellular localization image for SLC26A7 gene
Compartment Confidence
endosome 5
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for SLC26A7 Gene

Pathways & Interactions for SLC26A7 Gene

genes like me logo Genes that share pathways with SLC26A7: view

Interacting Proteins for SLC26A7 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000309504%0d%0a9606.ENSP00000405600%0d%0a9606.ENSP00000007516%0d%0a9606.ENSP00000431822%0d%0a9606.ENSP00000003084%0d%0a
Selected Interacting proteins: ENSP00000309504 for SLC26A7 Gene via STRING

Gene Ontology (GO) - Biological Process for SLC26A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006820 anion transport IDA 11834742
GO:0006821 chloride transport IDA 1183472
GO:0019532 oxalate transport IDA 1183472
GO:0051453 regulation of intracellular pH IBA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC26A7: view

No data available for SIGNOR curated interactions for SLC26A7 Gene

Drugs & Compounds for SLC26A7 Gene

(3) Additional Compounds for SLC26A7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
Hydrogen carbonate
  • Bicarbonate
  • Bicarbonate (HCO3-)
  • Bicarbonate anion
  • Bicarbonate ion
  • Bicarbonate ion (HCO31-)
71-52-3
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC26A7: view

Transcripts for SLC26A7 Gene

Unigene Clusters for SLC26A7 Gene

Solute carrier family 26, member 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A7 Gene

No ASD Table

Relevant External Links for SLC26A7 Gene

GeneLoc Exon Structure for
SLC26A7
ECgene alternative splicing isoforms for
SLC26A7

Expression for SLC26A7 Gene

mRNA expression in normal human tissues for SLC26A7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC26A7 Gene

This gene is overexpressed in Thyroid (x46.5).

Protein differential expression in normal tissues from HIPED for SLC26A7 Gene

This gene is overexpressed in Thyroid (58.3) and Adipocyte (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC26A7 Gene



SOURCE GeneReport for Unigene cluster for SLC26A7 Gene Hs.354013

mRNA Expression by UniProt/SwissProt for SLC26A7 Gene

Q8TE54-S26A7_HUMAN
Tissue specificity: Expressed in tonsillar high endothelial venule endothelial cells (HEVEC), placenta and in testis, expressed in a subgroup of basal cells in the epididymal ducts.
genes like me logo Genes that share expression patterns with SLC26A7: view

Protein tissue co-expression partners for SLC26A7 Gene

Primer Products

In Situ Assay Products

Orthologs for SLC26A7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC26A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC26A7 35
  • 98.95 (n)
  • 98.74 (a)
SLC26A7 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC26A7 36
  • 87 (a)
OneToOne
SLC26A7 35
  • 88.19 (n)
  • 87.94 (a)
dog
(Canis familiaris)
Mammalia SLC26A7 35
  • 90.09 (n)
  • 90.85 (a)
SLC26A7 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc26a7 16
Slc26a7 36
  • 86 (a)
OneToOne
Slc26a7 35
  • 86.99 (n)
  • 87.65 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC26A7 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC26A7 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc26a7 35
  • 84.64 (n)
  • 84.69 (a)
chicken
(Gallus gallus)
Aves SLC26A7 36
  • 73 (a)
OneToOne
SLC26A7 35
  • 73.38 (n)
  • 74.2 (a)
lizard
(Anolis carolinensis)
Reptilia SLC26A7 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc26a7 35
  • 62.99 (n)
  • 58.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Prestin 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sulp-2 36
  • 25 (a)
ManyToMany
sulp-3 36
  • 23 (a)
ManyToMany
sulp-4 36
  • 25 (a)
ManyToMany
sulp-5 36
  • 26 (a)
ManyToMany
sulp-6 36
  • 22 (a)
ManyToMany
sulp-7 36
  • 29 (a)
ManyToMany
sulp-8 36
  • 27 (a)
ManyToMany
F14D12.5 37
  • 27 (a)
F41D9.5 37
  • 28 (a)
K12G11.2 37
  • 31 (a)
W01B11.2 37
  • 29 (a)
W04G3.6 37
  • 34 (a)
ZK287.2 37
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUL1 36
  • 13 (a)
ManyToMany
SUL2 36
  • 12 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for SLC26A7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC26A7 Gene

ENSEMBL:
Gene Tree for SLC26A7 (if available)
TreeFam:
Gene Tree for SLC26A7 (if available)

Paralogs for SLC26A7 Gene

(10) SIMAP similar genes for SLC26A7 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC26A7: view

Variants for SLC26A7 Gene

Sequence variations from dbSNP and Humsavar for SLC26A7 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs16912250 - 91,334,295(+) TGTAG(A/G)TTTAT reference, missense, utr-variant-5-prime
rs34921316 - 91,351,811(+) ACAGG(G/T)GGCTT reference, missense
rs980904 -- 91,315,598(-) ACAGT(A/C)AACTC intron-variant
rs980905 -- 91,315,591(-) ACTCA(A/G)GACGC intron-variant
rs996694 -- 91,330,037(-) TACTT(C/G)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC26A7 Gene

Variant ID Type Subtype PubMed ID
essv220 CNV CNV 17122850
nsv6302 CNV Loss 18451855
nsv891190 CNV Loss 21882294
nsv523642 CNV Gain 19592680

Variation tolerance for SLC26A7 Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.36; 53.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC26A7 Gene

HapMap Linkage Disequilibrium report
SLC26A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC26A7 Gene

Disorders for SLC26A7 Gene

Relevant External Links for SLC26A7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC26A7

No disorders were found for SLC26A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC26A7 Gene

Publications for SLC26A7 Gene

  1. Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney. (PMID: 11829495) Vincourt J.-B. … Girard J.-P. (Genomics 2002) 2 3 4 23 67
  2. Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion. (PMID: 16524946) Xu J. … Soleimani M. (J. Am. Soc. Nephrol. 2006) 2 3
  3. Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. (PMID: 11834742) Lohi H. … Kere J. (J. Biol. Chem. 2002) 2 3
  4. N-glycosylation and topology of the human SLC26 family of anion transport membrane proteins. (PMID: 24647542) Li J. … Reithmeier R.A. (Am. J. Physiol., Cell Physiol. 2014) 3
  5. Exome sequencing supports a de novo mutational paradigm for schizophrenia. (PMID: 21822266) Xu B. … Karayiorgou M. (Nat. Genet. 2011) 3

Products for SLC26A7 Gene

Sources for SLC26A7 Gene

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