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SLC26A7 Gene

protein-coding   GIFtS: 54
GCID: GC08P092221

Solute Carrier Family 26 (Anion Exchanger), Member 7

(Previous names: solute carrier family 26, member 7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 26 (Anion Exchanger), Member 71 2
Solute Carrier Family 26, Member 71 2
SUT22 3
Anion Exchange Transporter2
Sulfate Anion Transporter2
Solute Carrier Family 26 Member 73

External Ids:    HGNC: 144671   Entrez Gene: 1151112   Ensembl: ENSG000001476067   OMIM: 6084795   UniProtKB: Q8TE543   

Export aliases for SLC26A7 gene to outside databases

Previous GC identifers: GC08P090739 GC08P092107 GC08P091930 GC08P092218 GC08P092330 GC08P087472


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC26A7 Gene:
This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in gene
structure and protein length yet have markedly different tissue expression patterns. This gene has abundant and
specific expression in the kidney. Alternatively spliced transcript variants that encode different isoforms have
been described. (provided by RefSeq, Aug 2013)

GeneCards Summary for SLC26A7 Gene:
SLC26A7 (solute carrier family 26 (anion exchanger), member 7) is a protein-coding gene. Diseases associated with SLC26A7 include ventricular septal defect, and diastrophic dysplasia. GO annotations related to this gene include anion:anion antiporter activity and chloride channel activity. An important paralog of this gene is SLC26A9.

UniProtKB/Swiss-Prot: S26A7_HUMAN, Q8TE54
Function: Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and
oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney,
by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion

Gene Wiki entry for SLC26A7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC26A7 gene promoter:
         AML1a   Pbx1a   POU6F1 (c2)   STAT5A   Ik-3   Meis-1b   FOXL1   AREB6   HOXA5   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC26A7 promoter sequence
   Search Chromatin IP Primers for SLC26A7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC26A7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q23   Ensembl cytogenetic band:  8q21.3   HGNC cytogenetic band: 8q23

SLC26A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC26A7 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P092221:  view genomic region     (about GC identifiers)

Start:
92,221,722 bp from pter      End:
92,410,378 bp from pter
Size:
188,657 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: S26A7_HUMAN, Q8TE54 (See protein sequence)
Recommended Name: Anion exchange transporter  
Size: 656 amino acids; 72213 Da
Miscellaneous: Is active at both alkaline and acidic pH. Activity is inhibited by
4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and
transporters)
Secondary accessions: Q24JS8 Q8TE53 Q96RN2
Alternative splicing: 2 isoforms:  Q8TE54-1   Q8TE54-2   

Explore the universe of human proteins at neXtProt for SLC26A7: NX_Q8TE54

Explore proteomics data for SLC26A7 at MOPED


See SLC26A7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (4 alternative transcripts): 
NP_001269285.1  NP_001269286.1  NP_439897.1  NP_599028.1  

ENSEMBL proteins: 
 ENSP00000427712   ENSP00000428881   ENSP00000428849   ENSP00000276609   ENSP00000309504  
 ENSP00000428747  
Reactome Protein details: Q8TE54

SLC26A7 Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for SLC26A7

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Cloud-Clone Corp. CLIAs for SLC26A7


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SLC: Solute carriers

IUPHAR Guide to PHARMACOLOGY protein family classification: SLC26A7
Anion channels

2 InterPro protein domains:
 IPR002645 STAS_dom
 IPR011547 Sulph_transpt

Graphical View of Domain Structure for InterPro Entry Q8TE54

ProtoNet protein and cluster: Q8TE54

1 Blocks protein domain: IPB001902 Sulphate transporter

UniProtKB/Swiss-Prot: S26A7_HUMAN, Q8TE54
Similarity: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family
Similarity: Contains 1 STAS domain


SLC26A7 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: S26A7_HUMAN, Q8TE54
Function: Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and
oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney,
by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion

     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005253anion channel activity ----
GO:0005254chloride channel activity IDA1183472
GO:0015106bicarbonate transmembrane transporter activity ISS12736153
GO:0015116sulfate transmembrane transporter activity IDA1183472
GO:0015301anion:anion antiporter activity IEA--
     
SLC26A7 for ontologies           About GeneDecksing


Phenotypes:
     3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc26a7):
 digestive/alimentary  homeostasis/metabolism  renal/urinary system 

SLC26A7 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Slc26a7tm1Sole for SLC26A7

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC26A7
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miRNA
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miRTarBase miRNAs that target SLC26A7:
hsa-mir-1 (MIRT023903), hsa-mir-335-5p (MIRT018335)

Block miRNA regulation of human, mouse, rat SLC26A7 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate SLC26A7 (see all 56):
hsa-miR-26a-2* hsa-miR-4307 hsa-miR-4328 hsa-miR-200a hsa-miR-141 hsa-miR-223 hsa-miR-186 hsa-miR-222*
SwitchGear 3'UTR luciferase reporter plasmidSLC26A7 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat SLC26A7

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GenScript: all cDNA clones in your preferred vector (see all 2): SLC26A7 (NM_134266)
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC26A7


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
S26A7_HUMAN, Q8TE54: Recycling endosome membrane; Multi-pass membrane protein. Note=Expressed in the cytoplasm in
recycling endosomes of medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to
the basolateral membrane in hypertonicity and potassium depletion
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
endosome5
plasma membrane4

Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IDA16524946
GO:0005768endosome IDA16524946
GO:0005886plasma membrane TAS--
GO:0016021integral component of membrane IEA--
GO:0016323basolateral plasma membrane IMP16524946

SLC26A7 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for SLC26A7 About    
See pathways by source

SuperPathContained pathways About
1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
SLC-mediated transmembrane transport0.47
Transport of inorganic cations/anions and amino acids/oligopeptides0.38
Transmembrane transport of small molecules0.47
Multifunctional anion exchangers0.00
2Salivary secretion
Gastric acid secretion0.34

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for SLC26A7
    Multifunctional anion exchangers


1 Kegg Pathway  (Kegg details for SLC26A7):
    Gastric acid secretion


SLC26A7 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC26A7
Interactions:

    Search GeneGlobe Interaction Network for SLC26A7

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for SLC26A7 (ENSP000003095044) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
SLC4A2ENSP000003114024STRING: ENSP00000311402
NDUFAB1ENSP000000075164STRING: ENSP00000007516
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Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001696gastric acid secretion IEA--
GO:0006811ion transport TAS--
GO:0006820anion transport IDA11834742
GO:0006821chloride transport IDA1183472
GO:0008272sulfate transport IDA1183472

SLC26A7 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SLC26A7 (S26A7)

3 HMDB Compounds for SLC26A7    About this table
CompoundSynonyms CAS #PubMed Ids
ChlorineCl2 (see all 13)16887-00-6--
Hydrogen carbonateBicarbonate (see all 19)71-52-3--
SodiumSodium (see all 2)7440-23-5--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for SLC26A7 gene (4 alternative transcripts): 
NM_001282356.1  NM_001282357.1  NM_052832.3  NM_134266.1  

Unigene Cluster for SLC26A7:

Solute carrier family 26, member 7
Hs.354013  [show with all ESTs]
Unigene Representative Sequence: NM_052832
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000522181 ENST00000522862 ENST00000523719 ENST00000276609(uc003yex.3 uc003yey.3 uc003yfa.3)
ENST00000309536(uc003yez.3) ENST00000520818 ENST00000520249 ENST00000517930

miRNA
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Selected qRT-PCR Assays for microRNAs that regulate SLC26A7 (see all 56):
hsa-miR-26a-2* hsa-miR-4307 hsa-miR-4328 hsa-miR-200a hsa-miR-141 hsa-miR-223 hsa-miR-186 hsa-miR-222*
SwitchGear 3'UTR luciferase reporter plasmidSLC26A7 3' UTR sequence
Inhib. RNA
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Clone
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OriGene ORF clones in mouse, rat for SLC26A7
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): SLC26A7 (NM_134266)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC26A7
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC26A7
Primer
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  QuantiFast Probe-based Assays in human, mouse, rat SLC26A7

Additional mRNA sequence: 

AF331521.1 AJ413228.1 AJ413229.2 AJ413230.1 AK122933.1 BC113866.1 BC114474.1 

8 DOTS entries:

DT.40206364  DT.75159609  DT.40250744  DT.99962126  DT.100735822  DT.40106731  DT.99941677  DT.100735821 

Selected AceView cDNA sequences (see all 138):

AA449912 BM975667 AW276475 BC029760 BX642399 BU618683 AA252475 BX281278 
AJ413228 AW514714 AA812488 BM726084 AA449911 CA773890 AW182183 AI363745 
BG661273 AI343847 NM_052832 AK130865 BF435752 AA813899 BI712470 AJ413229 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SLC26A7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAAATAAATC
SLC26A7 Expression
About this image


SLC26A7 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 16) fully expand
 
 Brain (Nervous System)    fully expand to see all 5 entries
         Thalamus
         Caudal astroglia-like cells
 
 Kidney (Urinary System)    fully expand to see all 3 entries
         Ureteric Bud Cells Ureteric Bud
         Metanephros
 
 Bone (Muscoskeletal System)    fully expand to see all 3 entries
         Mesenchymal Condensate Cells Zeugopod
         Zeugopod Long Bone
 
 Limb (Muscoskeletal System)    fully expand to see all 3 entries
         Mesenchymal Condensate Cells Zeugopod
         Zeugopod
 
 Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
         Mesenchymal Condensate Cells Zeugopod
         Laryngeal Cartilage
SLC26A7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SLC26A7 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.354013

UniProtKB/Swiss-Prot: S26A7_HUMAN, Q8TE54
Tissue specificity: Expressed in tonsillar high endothelial venule endothelial cells (HEVEC), placenta and in
testis, expressed in a subgroup of basal cells in the epididymal ducts

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC26A7

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC26A7 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Slc26a71 , 5 solute carrier family 26, member 71, 5 86.99(n)1
87.65(a)1
  4 (6.24 cM)5
2088901  NM_145947.21  NP_666059.21 
 145024305 
chicken
(Gallus gallus)
Aves SLC26A71 solute carrier family 26, member 7 73.38(n)
74.2(a)
  428369  XM_425930.4  XP_425930.4 
lizard
(Anolis carolinensis)
Reptilia SLC26A76
solute carrier family 26 (anion exchanger), member...
72(a)
1 ↔ 1
4(17437297-17541896)
tropical clawed frog
(Xenopus tropicalis)
Amphibia slc26a71 solute carrier family 26, member 7 62.99(n)
58.58(a)
  100493278  XM_002934422.2  XP_002934468.2 
fruit fly
(Drosophila melanogaster)
Insecta Prestin6
Prestin
24(a)
1 → many
3L(17891989-17900912)
worm
(Caenorhabditis elegans)
Secernentea W04G3.63 dra like protein 34(a)
(best of 6)
  X(11115908-11117663)   --
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUL16
SUL26
High affinity sulfate permease of the SulP anion t...
High affinity sulfate permease; sulfate uptake is ...
13(a)
12(a)
many ↔ many
many ↔ many
II(789235-791814) YBR294W
XII(323544-326225) YLR092W


ENSEMBL Gene Tree for SLC26A7 (if available)
TreeFam Gene Tree for SLC26A7 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SLC26A7 gene
SLC26A92  SLC26A32  SLC26A62  SLC26A12  SLC26A52  SLC26A112  SLC26A22  SLC26A102  
SLC26A42  SLC26A82  
10 SIMAP similar genes for SLC26A7 using alignment to 4 protein entries:     S26A7_HUMAN (see all proteins):
SLC26A6    SLC26A4    SLC26A5    SLC26A10    SLC26A3    SLC26A9
DKFZp686P10213    SLC26A2    PRES    RESDA1

SLC26A7 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SLC26A7 (see all 2625)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs339337611,2
C--92259752(+) AAAAA-/CATCTG 2 -- us2k10--------
rs636481631,2
--92259752(+) AAAAAC/AATCTG 2 -- us2k11Minor allele frequency- A:0.50NA 2
rs1889480721,2
--92259793(+) AAGATG/TTTTAG 2 -- us2k10--------
rs1923529751,2
--92259822(+) TTAAGA/GAATTT 2 -- us2k10--------
rs736971611,2
C,F--92259958(+) TGTTCA/TTGTGA 2 -- us2k12Minor allele frequency- T:0.06WA 120
rs1842564941,2
--92259963(+) ATGTGA/CATTTT 2 -- us2k10--------
rs1888591241,2
--92260016(+) CACAAA/GTGATA 2 -- us2k10--------
rs117872251,2
C,F,A,H--92260023(+) GATAGA/TTGTTG 2 -- us2k116Minor allele frequency- T:0.38NS EA NA WA 1266
rs101125201,2
C,F,H--92260029(+) TGTTGA/GTTGGT 2 -- us2k16Minor allele frequency- G:0.06NS EA WA NA 656
rs736971621,2
C,F--92260085(+) CGTTAG/TAATTT 2 -- us2k12Minor allele frequency- T:0.06WA 120

HapMap Linkage Disequilibrium report for SLC26A7 (92221722 - 92410378 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for SLC26A7:    About this table    
Variant IDTypeSubtypePubMed ID
nsv6302CNV Loss18451855
nsv891190CNV Loss21882294
nsv523642CNV Gain19592680
essv220CNV CNV17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608479    OMIM disorders: --

13 diseases for SLC26A7:    
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ventricular septal defect    diastrophic dysplasia    congenital dyserythropoietic anemia    fainting
epididymitis    labyrinthitis    hypertension    schizophrenia
tuberculosis    endotheliitis    thyroiditis    hepatitis
prostatitis

1 disease from the University of Copenhagen DISEASES database for SLC26A7:
Diastrophic dysplasia

SLC26A7 for disorders           About GeneDecksing


Export disorders for SLC26A7 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SLC26A7 gene, integrated from 10 sources (see all 15):
(articles sorted by number of sources associating them with SLC26A7)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney. (PubMed id 11829495)1, 2, 3, 9 Vincourt J.-B.... Girard J.-P. (Genomics 2002)
  2. Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion. (PubMed id 16524946)1, 2, 3 Xu J....Soleimani M. (J. Am. Soc. Nephrol. 2006)
  3. Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. (PubMed id 11834742)1, 2, 3 Lohi H.... Kere J. (J. Biol. Chem. 2002)
  4. SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney. (PubMed id 15956810)1, 2 Kujala M....Kere J. (Nephron Exp. Nephrol. 2005)
  5. Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells. (PubMed id 12736153)1, 2 Petrovic S.... Soleimani M. (Am. J. Physiol. 2003)
  6. Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men. (PubMed id 21897333)1 Irvin M.R....Arnett D.K. (Pharmacogenet. Genomics 2011)
  7. Exome sequencing supports a de novo mutational paradigm for schizophrenia. (PubMed id 21822266)1 Xu B....Karayiorgou M. (Nat. Genet. 2011)
  8. Expression of ion transport-associated proteins in human efferent and epididymal ducts. (PubMed id 17504921)2 Kujala M.... Hoglund P. (Reproduction 2007)
  9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  10. Differential regulation of basolateral Cl-/HCO3- exchangers SLC26A7 and AE1 in kidney outer medullary collecting duct. (PubMed id 15284286)1 Barone S....Soleimani M. (J. Am. Soc. Nephrol. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 115111 HGNC: 14467 AceView: CGI-77andSLC26A7 Ensembl:ENSG00000147606 euGenes: HUgn115111
ECgene: SLC26A7 Kegg: 115111 H-InvDB: SLC26A7

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SLC26A7 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SLC26A7 gene:
Search GeneIP for patents involving SLC26A7

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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