Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC26A7 Gene

protein-coding   GIFtS: 55
GCID: GC08P092221

Solute Carrier Family 26 (Anion Exchanger), Member 7

(Previous names: solute carrier family 26, member 7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 26 (Anion Exchanger), Member 71 2
Solute Carrier Family 26, Member 71 2
SUT22 3
Anion Exchange Transporter2
Sulfate Anion Transporter2
Solute Carrier Family 26 Member 73

External Ids:    HGNC: 144671   Entrez Gene: 1151112   Ensembl: ENSG000001476067   OMIM: 6084795   UniProtKB: Q8TE543   

Export aliases for SLC26A7 gene to outside databases

Previous GC identifers: GC08P090739 GC08P092107 GC08P091930 GC08P092218 GC08P092330 GC08P087472


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC26A7 Gene:
This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in gene
structure and protein length yet have markedly different tissue expression patterns. This gene has abundant and
specific expression in the kidney. Alternatively spliced transcript variants that encode different isoforms have
been described. (provided by RefSeq, Aug 2013)

GeneCards Summary for SLC26A7 Gene: 
SLC26A7 (solute carrier family 26 (anion exchanger), member 7) is a protein-coding gene. Diseases associated with SLC26A7 include ventricular septal defect, and diastrophic dysplasia, and among its related super-pathways are Transmembrane transport of small molecules and Amino acid and oligopeptide SLC transporters. GO annotations related to this gene include anion:anion antiporter activity and chloride channel activity. An important paralog of this gene is SLC26A9.

UniProtKB/Swiss-Prot: S26A7_HUMAN, Q8TE54
Function: Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and
oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney,
by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion

Gene Wiki entry for SLC26A7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC26A7 gene promoter:
         AML1a   Pbx1a   POU6F1 (c2)   STAT5A   Ik-3   Meis-1b   FOXL1   AREB6   HOXA5   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC26A7 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC26A7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC26A7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q23   Ensembl cytogenetic band:  8q21.3   HGNC cytogenetic band: 8q23

SLC26A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC26A7 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P092221:  view genomic region     (about GC identifiers)

Start:
92,221,722 bp from pter      End:
92,410,378 bp from pter
Size:
188,657 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S26A7_HUMAN, Q8TE54 (See protein sequence)
Recommended Name: Anion exchange transporter  
Size: 656 amino acids; 72213 Da
Subcellular location: Recycling endosome membrane; Multi-pass membrane protein. Note=Expressed in the cytoplasm in
recycling endosomes of medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to
the basolateral membrane in hypertonicity and potassium depletion
Miscellaneous: Is active at both alkaline and acidic pH. Activity is inhibited by
4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and
transporters)
Secondary accessions: Q24JS8 Q8TE53 Q96RN2
Alternative splicing: 2 isoforms:  Q8TE54-1   Q8TE54-2   

Explore the universe of human proteins at neXtProt for SLC26A7: NX_Q8TE54

Explore proteomics data for SLC26A7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TE54

  • SLC26A7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC26A7 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001269285.1  NP_001269286.1  NP_439897.1  NP_599028.1  

    ENSEMBL proteins: 
     ENSP00000427712   ENSP00000428881   ENSP00000428849   ENSP00000276609   ENSP00000309504  
     ENSP00000428747  
    Reactome Protein details: Q8TE54
    Human Recombinant Protein Products for SLC26A7: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SLC26A7
    GenScript Custom Purified and Recombinant Proteins Services for SLC26A7
    Novus Biologicals SLC26A7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLC26A7 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA16524946
    GO:0005768endosome IDA16524946
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0016323basolateral plasma membrane IMP16524946

    SLC26A7 for ontologies           About GeneDecksing



    SLC26A7 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLC26A7
    GenScript Custom Superior Antibodies Services for SLC26A7
    Novus Biologicals SLC26A7 Antibodies
    Search for Antibodies for SLC26A7 at Abcam
    Cloud-Clone Corp. Antibodies for SLC26A7 
    Search ThermoFisher Antibodies for SLC26A7
    LSBio Antibodies in human, mouse, rat for SLC26A7 

    Assay Products for SLC26A7: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC26A7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC26A7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SLC26A7 
    Cloud-Clone Corp. CLIAs for SLC26A7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: SLC26A7 
    Anion channels

    2 InterPro protein domains:
     IPR002645 STAS_dom
     IPR011547 Sulph_transpt

    Graphical View of Domain Structure for InterPro Entry Q8TE54

    ProtoNet protein and cluster: Q8TE54

    1 Blocks protein domain: IPB001902 Sulphate transporter

    UniProtKB/Swiss-Prot: S26A7_HUMAN, Q8TE54
    Similarity: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family
    Similarity: Contains 1 STAS domain


    SLC26A7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S26A7_HUMAN, Q8TE54
    Function: Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and
    oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney,
    by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005253anion channel activity ----
    GO:0005254chloride channel activity IDA1183472
    GO:0015106bicarbonate transmembrane transporter activity ISS12736153
    GO:0015116sulfate transmembrane transporter activity IDA1183472
    GO:0015301anion:anion antiporter activity IEA--
         
    SLC26A7 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc26a7):
     digestive/alimentary  homeostasis/metabolism  renal/urinary system 

    SLC26A7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Slc26a7tm1Sole for SLC26A7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC26A7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC26A7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC26A7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC26A7 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC26A7
    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC26A7 (see all 56):
    hsa-miR-26a-2* hsa-miR-4307 hsa-miR-4328 hsa-miR-200a hsa-miR-141 hsa-miR-223 hsa-miR-186 hsa-miR-222*
    SwitchGear 3'UTR luciferase reporter plasmidSLC26A7 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC26A7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC26A7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC26A7
    Sirion Biotech Customized adenovirus for overexpression of SLC26A7

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SLC26A7 (see all 11)
    OriGene ORF clones in mouse, rat for SLC26A7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC26A7 (NM_134266)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC26A7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC26A7
    Sirion Biotech Customized lentivirus for stable overexpression of SLC26A7 
                         Customized lentivirus expression plasmids for stable overexpression of SLC26A7 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC26A7
    Search LifeMap BioReagents cell lines for SLC26A7
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC26A7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC26A7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transmembrane transport of small molecules0.50
    2Amino acid and oligopeptide SLC transporters
    Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    3Gastric acid secretion
    Gastric acid secretion0.34
    4Multifunctional anion exchangers
    Multifunctional anion exchangers

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for SLC26A7
        Multifunctional anion exchangers
    SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of inorganic cations/anions and amino acids/oligopeptides


    1         Kegg Pathway  (Kegg details for SLC26A7):
        Gastric acid secretion


    SLC26A7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC26A7

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLC26A7 (ENSP000003095044) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC4A2ENSP000003114024STRING: ENSP00000311402
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001696gastric acid secretion IEA--
    GO:0006811ion transport TAS--
    GO:0006820anion transport IDA11834742
    GO:0006821chloride transport IDA1183472
    GO:0008272sulfate transport IDA1183472

    SLC26A7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC26A7 (S26A7)

    3 HMDB Compounds for SLC26A7    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    Hydrogen carbonateBicarbonate (see all 19)71-52-3--
    SodiumSodium (see all 2)7440-23-5--

    Search CenterWatch for drugs/clinical trials and news about SLC26A7 / S26A7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC26A7 gene (4 alternative transcripts): 
    NM_001282356.1  NM_001282357.1  NM_052832.3  NM_134266.1  

    Unigene Cluster for SLC26A7:

    Solute carrier family 26, member 7
    Hs.354013  [show with all ESTs]
    Unigene Representative Sequence: NM_052832
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000522181 ENST00000522862 ENST00000523719 ENST00000276609(uc003yex.3 uc003yey.3 uc003yfa.3)
    ENST00000309536(uc003yez.3) ENST00000520818 ENST00000520249 ENST00000517930

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC26A7
    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC26A7 (see all 56):
    hsa-miR-26a-2* hsa-miR-4307 hsa-miR-4328 hsa-miR-200a hsa-miR-141 hsa-miR-223 hsa-miR-186 hsa-miR-222*
    SwitchGear 3'UTR luciferase reporter plasmidSLC26A7 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC26A7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC26A7
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC26A7 (see all 11)
    OriGene ORF clones in mouse, rat for SLC26A7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC26A7 (NM_134266)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC26A7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC26A7
    Sirion Biotech Customized lentivirus for stable overexpression of SLC26A7 
                         Customized lentivirus expression plasmids for stable overexpression of SLC26A7 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC26A7
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC26A7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC26A7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC26A7

    Additional mRNA sequence: 

    AF331521.1 AJ413228.1 AJ413229.2 AJ413230.1 AK122933.1 BC113866.1 BC114474.1 

    8 DOTS entries:

    DT.40206364  DT.75159609  DT.40250744  DT.99962126  DT.100735822  DT.40106731  DT.99941677  DT.100735821 

    24/138 AceView cDNA sequences (see all 138):

    BI712470 AJ413229 NM_016023 AJ413230 BM542164 NM_134266 AF331521 AW571925 
    BM975667 AW276475 BC029760 BX642399 BU618683 AA252475 BX281278 AJ413228 
    AW514714 AA812488 BM726084 AA449911 CA773890 AW182183 AI363745 BG661273 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC26A7 expression in normal human tissues (normalized intensities)      SLC26A7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATAAATC
    SLC26A7 Expression
    About this image


    SLC26A7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/27 selected tissues (see all 27) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 7 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Long Bone
             sensory organ/ear/inner ear   
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Thalamus
             brain/midbrain/lateral wall   
     
     Limb (Muscoskeletal System)    fully expand to see all 5 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod
             limb/hindlimb   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Mesenchymal Condensate Cells Zeugopod
             sensory organ/ear/inner ear   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
             brain/midbrain/lateral wall   

    See SLC26A7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC26A7

    SOURCE GeneReport for Unigene cluster: Hs.354013

    UniProtKB/Swiss-Prot: S26A7_HUMAN, Q8TE54
    Tissue specificity: Expressed in tonsillar high endothelial venule endothelial cells (HEVEC), placenta and in
    testis, expressed in a subgroup of basal cells in the epididymal ducts

        SABiosciences Custom PCR Arrays for SLC26A7
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC26A7
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC26A7
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC26A7
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC26A7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC26A7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC26A7 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc26a71 , 5 solute carrier family 26, member 71, 5 86.99(n)1
    87.65(a)1
      4 (6.24 cM)5
    2088901  NM_145947.21  NP_666059.21 
     145024305 
    chicken
    (Gallus gallus)
    Aves SLC26A71 solute carrier family 26, member 7 73.89(n)
    75.35(a)
      428369  XM_425930.3  XP_425930.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLC26A76
    Uncharacterized protein
    72(a)
    1 ↔ 1
    4(17437297-17541896)
    fruit fly
    (Drosophila melanogaster)
    Insecta Prestin6
    Prestin
    22(a)
    1 → many
    3L(17891989-17900912)
    worm
    (Caenorhabditis elegans)
    Secernentea W04G3.63 dra like protein 34(a)
    (best of 6)
      X(11115908-11117663)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SUL16
    SUL26
    High affinity sulfate permease of the SulP anion t...
    High affinity sulfate permease; sulfate uptake is ...
    13(a)
    12(a)
    many ↔ many
    many ↔ many
    II(789235-791814)
    XII(323544-326225)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SULTR3;21 sulfate transporter 3.2 40.82(n)
    27.12(a)
      828201  NM_116504.3  NP_192179.1 


    ENSEMBL Gene Tree for SLC26A7 (if available)
    TreeFam Gene Tree for SLC26A7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC26A7 gene
    SLC26A92  SLC26A32  SLC26A62  SLC26A12  SLC26A52  SLC26A112  SLC26A22  SLC26A102  
    SLC26A42  SLC26A82  
    10 SIMAP similar genes for SLC26A7 using alignment to 4 protein entries:     S26A7_HUMAN (see all proteins):
    SLC26A6    SLC26A4    SLC26A5    SLC26A10    SLC26A3    SLC26A9
    DKFZp686P10213    SLC26A2    PRES    RESDA1

    SLC26A7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2625 SNPs in SLC26A7 are shown (see all 2625)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs339337611,2
    C--92259752(+) AAAAA-/CATCTG 2 -- us2k10--------
    rs636481631,2
    --92259752(+) AAAAAC/AATCTG 2 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1889480721,2
    --92259793(+) AAGATG/TTTTAG 2 -- us2k10--------
    rs1923529751,2
    --92259822(+) TTAAGA/GAATTT 2 -- us2k10--------
    rs736971611,2
    C,F--92259958(+) TGTTCA/TTGTGA 2 -- us2k12Minor allele frequency- T:0.06WA 120
    rs1842564941,2
    --92259963(+) ATGTGA/CATTTT 2 -- us2k10--------
    rs1888591241,2
    --92260016(+) CACAAA/GTGATA 2 -- us2k10--------
    rs117872251,2
    C,F,A,H--92260023(+) GATAGA/TTGTTG 2 -- us2k116Minor allele frequency- T:0.38NS EA NA WA 1266
    rs101125201,2
    C,F,H--92260029(+) TGTTGA/GTTGGT 2 -- us2k16Minor allele frequency- G:0.06NS EA WA NA 656
    rs736971621,2
    C,F--92260085(+) CGTTAG/TAATTT 2 -- us2k12Minor allele frequency- T:0.06WA 120

    HapMap Linkage Disequilibrium report for SLC26A7 (92221722 - 92410378 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SLC26A7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6302CNV Loss18451855
    nsv891190CNV Loss21882294
    nsv523642CNV Gain19592680
    essv220CNV CNV17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC26A7
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC26A7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608479    OMIM disorders: --

    10 diseases for SLC26A7:    About MalaCards
    ventricular septal defect    diastrophic dysplasia    congenital dyserythropoietic anemia    fainting
    epididymitis    anemia    hypertension    schizophrenia
    tuberculosis    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for SLC26A7:
    Diastrophic dysplasia

    SLC26A7 for disorders           About GeneDecksing


    Export disorders for SLC26A7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC26A7 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with SLC26A7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney. (PubMed id 11829495)1, 2, 3, 9 Vincourt J.-B.... Girard J.-P. (2002)
    2. Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion. (PubMed id 16524946)1, 2, 3 Xu J....Soleimani M. (2006)
    3. Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. (PubMed id 11834742)1, 2, 3 Lohi H.... Kere J. (2002)
    4. SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney. (PubMed id 15956810)1, 2 Kujala M....Kere J. (2005)
    5. Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells. (PubMed id 12736153)1, 2 Petrovic S.... Soleimani M. (2003)
    6. Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV- infected men. (PubMed id 21897333)1 Irvin M.R....Arnett D.K. (2011)
    7. Exome sequencing supports a de novo mutational paradi gm for schizophrenia. (PubMed id 21822266)1 Xu B....Karayiorgou M. (2011)
    8. Expression of ion transport-associated proteins in human efferent and epididymal ducts. (PubMed id 17504921)2 Kujala M.... Hoglund P. (2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Differential regulation of basolateral Cl-/HCO3- exchangers SLC26A7 and AE1 in kidney outer medullary collecting duct. (PubMed id 15284286)1 Barone S....Soleimani M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 115111 HGNC: 14467 AceView: CGI-77andSLC26A7 Ensembl:ENSG00000147606 euGenes: HUgn115111
    ECgene: SLC26A7 Kegg: 115111 H-InvDB: SLC26A7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC26A7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC26A7 gene:
    Search GeneIP for patents involving SLC26A7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SLC26A7  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC26A7  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC26A7   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC26A7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC26A7   OriGene Custom Protein Services for SLC26A7  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC26A7
     QIAGEN SeqTarget long-range PCR primers for resequencing SLC26A7
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC26A7
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC26A7
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC26A7
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC26A7
     GenScript Custom Purified and Recombinant Proteins Services for SLC26A7 GenScript cDNA clones with any tag delivered in your preferred vector for SLC26A7
     GenScript Custom Assay Services for SLC26A7 GenScript Custom Superior Antibodies Services for SLC26A7
     GenScript Custom overexpressing Cell Line Services for SLC26A7 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SLC26A7 promoter
     Search Chromatin IP Primers for SLC26A7
     RT2 qPCR Primer Assay in human, mouse, rat SLC26A7
     Search GNC Networks for SLC26A7
     SABiosciences Custom PCR Arrays for SLC26A7
     Search Tocris compounds for SLC26A7 (S26A7)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SLC26A7 antibodies
     SLC26A7 lysates
     Search for Antibodies for SLC26A7 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SLC26A7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SLC26A7
     Antibodies for SLC26A7
     ELISAs for SLC26A7
     CLIAs for SLC26A7
     Search LifeMap BioReagents cell lines for SLC26A7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC26A7
     SwitchGear 3'UTR luciferase reporter plasmids for SLC26A7
     SwitchGear Promoter luciferase reporter plasmids for SLC26A7
     Search ThermoFisher Antibodies for SLC26A7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC26A7
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC26A7
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC26A7
    Customized:
     lentivirus for stable overexpression of SLC26A7
     lentivirus expression plasmids for stable overexpression of SLC26A7
     adenovirus for overexpression of SLC26A7
     LSBio Antibodies in human, mouse, rat for SLC26A7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC26A7 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4