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Aliases for SLC26A6 Gene

Aliases for SLC26A6 Gene

  • Solute Carrier Family 26 Member 6 2 3 5
  • Pendrin-Like Protein 1 2 4
  • Solute Carrier Family 26 (Anion Exchanger), Member 6 2
  • Solute Carrier Family 26, Member 6 2
  • Anion Exchange Transporter 4
  • Sulfate Anion Transporter 2
  • Anion Transporter 1 2
  • Pendrin-L1 4
  • Pendrin L1 2

External Ids for SLC26A6 Gene

Previous GeneCards Identifiers for SLC26A6 Gene

  • GC03M048453
  • GC03M047946
  • GC03M048482
  • GC03M048623
  • GC03M048639
  • GC03M048640
  • GC03M048664

Summaries for SLC26A6 Gene

Entrez Gene Summary for SLC26A6 Gene

  • This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2013]

GeneCards Summary for SLC26A6 Gene

SLC26A6 (Solute Carrier Family 26 Member 6) is a Protein Coding gene. Diseases associated with SLC26A6 include Diarrhea 1, Secretory Chloride, Congenital and Proximal Renal Tubular Acidosis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Mineral absorption. GO annotations related to this gene include PDZ domain binding and secondary active sulfate transmembrane transporter activity. An important paralog of this gene is SLC26A5.

UniProtKB/Swiss-Prot for SLC26A6 Gene

  • Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH.

  • Isoform 4: Apical membrane chloride-bicarbonate exchanger. Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site.

Gene Wiki entry for SLC26A6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC26A6 Gene

Genomics for SLC26A6 Gene

Regulatory Elements for SLC26A6 Gene

Enhancers for SLC26A6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F048551 1.5 FANTOM5 ENCODE 4.8 +76.2 76223 15.4 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF207 TMA7 WDR6 NICN1 FCF1P2 COL7A1 MIR711 ATRIP ENSG00000244380 CCDC51 FBXW12
GH03F047778 1.2 ENCODE 4.8 +854.7 854693 5.2 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF589 NME6 CCDC12 MRPS18AP1 BOLA2P2 DHX30 MAP4 FCF1P2 SCAP SMARCC1
GH03F048477 0.9 Ensembl ENCODE 6.1 +156.7 156707 3.2 KLF1 MAX ZIC2 ZFHX2 IKZF1 MLLT1 MYC EGR2 ZXDB TMA7 SHISA5 ATRIP ENSG00000244380 CCDC51 PFKFB4 UCN2 COL7A1 MIR711 FBXW12
GH03F048543 0.8 Ensembl ENCODE 4.7 +92.0 92014 1.0 POLR2A GLIS1 REST ZBTB7A UCN2 COL7A1 MIR711 SHISA5 ATRIP CCDC51 TMA7 ENSG00000244380 FBXW12 CDC25A
GH03F048528 0.7 Ensembl 5.1 +106.8 106793 1.4 MNT ZIC2 ZFHX2 JUND ZNF366 POLR2A ZBTB48 NFE2 FOS PRDM10 PFKFB4 UCN2 MIR711 COL7A1 PLXNB1 ATRIP ENSG00000244380 CCDC51 TMA7 CDC25A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC26A6 on UCSC Golden Path with GeneCards custom track

Promoters for SLC26A6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001363494 -7 2201 HDGF PKNOX1 ARID4B SIN3A GLI4 DMAP1 ZNF48 ZNF2 GLIS2 ZNF143

Genomic Location for SLC26A6 Gene

Chromosome:
3
Start:
48,625,723 bp from pter
End:
48,635,493 bp from pter
Size:
9,771 bases
Orientation:
Minus strand

Genomic View for SLC26A6 Gene

Genes around SLC26A6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC26A6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC26A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC26A6 Gene

Proteins for SLC26A6 Gene

  • Protein details for SLC26A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXS9-S26A6_HUMAN
    Recommended name:
    Solute carrier family 26 member 6
    Protein Accession:
    Q9BXS9
    Secondary Accessions:
    • B4DMZ1
    • Q548A7
    • Q96Q90
    • Q9NQU1

    Protein attributes for SLC26A6 Gene

    Size:
    759 amino acids
    Molecular mass:
    82967 Da
    Quaternary structure:
    • Interacts (via C-terminal domain) with PDZK1 (via C-terminal PDZ domain); the interaction induces chloride and oxalate exchange transport. Interacts with CFTR, SLC26A3 and SLC9A3R1 (By similarity). Isoform 4 interacts (via C-terminal cytoplasmic domain) with CA2; the interaction stimulates chloride-bicarbonate exchange activity. Isoform 4 and isoform 5 interact with SLC9A3R1 (via the PDZ domains). Isoform 4 and isoform 5 interact with SLC9A3R2 (via the PDZ domains). Interacts with AHCYL1; the interaction increases SLC26A6 activity (By similarity).
    • Interacts (via C-terminal domain) with PDZK1 (via C-terminal PDZ domain); the interaction induces chloride and oxalate exchange transport. Interacts with CFTR, SLC26A3 and SLC9A3R1 (By similarity). Isoform 4 interacts (via C-terminal cytoplasmic domain) with CA2; the interaction stimulates chloride-bicarbonate exchange activity. Isoform 4 and isoform 5 interact with SLC9A3R1 (via the PDZ domains). Isoform 4 and isoform 5 interact with SLC9A3R2 (via the PDZ domains). Interacts with AHCYL1; the interaction increases SLC26A6 activity (By similarity).

    Alternative splice isoforms for SLC26A6 Gene

neXtProt entry for SLC26A6 Gene

Post-translational modifications for SLC26A6 Gene

  • Phosphorylated on serine residues by PKC; the phosphorylation disrupts interaction with carbonic anhydrase CA2 and reduces bicarbonate transport activity in a phorbol myristate acetate (PMA)-induced manner.
  • Glycosylation at Asn 167 and Asn 172
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC26A6 Gene

Domains & Families for SLC26A6 Gene

Gene Families for SLC26A6 Gene

Protein Domains for SLC26A6 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BXS9

UniProtKB/Swiss-Prot:

S26A6_HUMAN :
  • Contains 1 STAS domain.
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Domain:
  • Contains 1 STAS domain.
Family:
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
genes like me logo Genes that share domains with SLC26A6: view

Function for SLC26A6 Gene

Molecular function for SLC26A6 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Apical membrane chloride-formate exchange activity in the proximal tubules of the kidney and oxalate secretion in the duodenum are inhibited by 4,4-diisothiocyanatostilbene-2,2-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters) (By similarity). Apical membrane chloride-bicarbonate exchange activity of the pancreatic duct is inhibited by 4,4-diisothiocyanatostilbene-2,2-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters). Isoform 4, isoform 5 and isoform 6 chloride, bicarbonate and sulfate transport activities are inhibited by DIDS.
UniProtKB/Swiss-Prot Function:
Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH.
UniProtKB/Swiss-Prot Function:
Isoform 4: Apical membrane chloride-bicarbonate exchanger. Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site.
UniProtKB/Swiss-Prot Induction:
Down-regulated by pro-inflammatory cytokine IFN gamma.

Gene Ontology (GO) - Molecular Function for SLC26A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005254 chloride channel activity IBA --
GO:0005452 inorganic anion exchanger activity TAS --
GO:0008271 secondary active sulfate transmembrane transporter activity IEA --
GO:0008509 anion transmembrane transporter activity IEA --
GO:0015106 bicarbonate transmembrane transporter activity ISS --
genes like me logo Genes that share ontologies with SLC26A6: view
genes like me logo Genes that share phenotypes with SLC26A6: view

Animal Models for SLC26A6 Gene

MGI Knock Outs for SLC26A6:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC26A6

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLC26A6 Gene

Localization for SLC26A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC26A6 Gene

Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Microsome. Note=Localized in sperm membranes. Colocalizes with CFTR at the midpiece of sperm tail. Localizes to the apical membrane brush border of epithelial cells in the proximal tubules of kidney, of enterocytes of the small intestine and of gastric parietal cells in the stomach. May be translocated from the cytosolic surface of the cell membrane to the intracellular space by PKC in phorbol myristate acetate (PMA)-induced cells (By similarity). Colocalized with CA2 at the surface of the cell membrane in order to form a bicarbonate transport metabolon; colocalization is reduced in phorbol myristate acetate (PMA)-induced cells. {ECO:0000250}.
Isoform 4: Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Localizes to the apical and basolateral surfaces of tubular wall cells in kidney and in the brush border of pancreatic duct cells.
Isoform 5: Cell membrane; Multi-pass membrane protein.
Isoform 6: Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC26A6 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 3
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC26A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,IBA --
GO:0012506 vesicle membrane ISS --
GO:0016020 membrane IEA,ISS --
genes like me logo Genes that share ontologies with SLC26A6: view

Pathways & Interactions for SLC26A6 Gene

genes like me logo Genes that share pathways with SLC26A6: view

Gene Ontology (GO) - Biological Process for SLC26A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport TAS --
GO:0006820 anion transport IEA --
GO:0006821 chloride transport IMP 20501439
GO:0008272 sulfate transport IEA,ISS --
genes like me logo Genes that share ontologies with SLC26A6: view

No data available for SIGNOR curated interactions for SLC26A6 Gene

Transcripts for SLC26A6 Gene

Unigene Clusters for SLC26A6 Gene

Solute carrier family 26, member 6:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A6 Gene

No ASD Table

Relevant External Links for SLC26A6 Gene

GeneLoc Exon Structure for
SLC26A6
ECgene alternative splicing isoforms for
SLC26A6

Expression for SLC26A6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC26A6 Gene

mRNA differential expression in normal tissues according to GTEx for SLC26A6 Gene

This gene is overexpressed in Whole Blood (x4.0) and Colon - Transverse (x4.0).

Protein differential expression in normal tissues from HIPED for SLC26A6 Gene

This gene is overexpressed in Urine (34.2), Placenta (15.6), and Fetal Liver (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC26A6 Gene



Protein tissue co-expression partners for SLC26A6 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC26A6 Gene:

SLC26A6

SOURCE GeneReport for Unigene cluster for SLC26A6 Gene:

Hs.631925

mRNA Expression by UniProt/SwissProt for SLC26A6 Gene:

Q9BXS9-S26A6_HUMAN
Tissue specificity: Ubiquitous. Highest levels in kidney and pancreas. Lower expression in heart, skeletal muscle, liver and placenta. Also found in lung and brain. Isoform 4 is ubiquitously expressed. Isoform 6 is expressed in heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis and ovary. Isoform 5 is expressed weakly in placenta, lung, liver and pancreas.
genes like me logo Genes that share expression patterns with SLC26A6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC26A6 Gene

Orthologs for SLC26A6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC26A6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC26A6 34 35
  • 99.43 (n)
dog
(Canis familiaris)
Mammalia SLC26A6 35 34
  • 84.77 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC26A6 34 35
  • 84.48 (n)
mouse
(Mus musculus)
Mammalia Slc26a6 34 16 35
  • 81.04 (n)
rat
(Rattus norvegicus)
Mammalia Slc26a6 34
  • 80.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC26A6 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC26A6 35 34
  • 65.19 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC26A6 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc26a6 34
  • 58.55 (n)
Str.15215 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.5431 34
zebrafish
(Danio rerio)
Actinopterygii slc26a6 34 35 35
  • 57.18 (n)
slc26a6l 35
  • 44 (a)
OneToMany
SLC26A6 (3 of 4) 35
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5485 36
  • 34 (a)
CG9717 36
  • 25 (a)
Esp 36
  • 25 (a)
worm
(Caenorhabditis elegans)
Secernentea K12G11.2 36
  • 35 (a)
W04G3.6 36
  • 34 (a)
ZK287.2 36
  • 34 (a)
W01B11.2 36
  • 32 (a)
F14D12.5 36
  • 31 (a)
K12G11.1 36
  • 31 (a)
F41D9.5 36
  • 25 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SULTR4;2 34
  • 42.33 (n)
rice
(Oryza sativa)
Liliopsida Os09g0240500 34
  • 42.68 (n)
Species where no ortholog for SLC26A6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC26A6 Gene

ENSEMBL:
Gene Tree for SLC26A6 (if available)
TreeFam:
Gene Tree for SLC26A6 (if available)

Paralogs for SLC26A6 Gene

Variants for SLC26A6 Gene

Sequence variations from dbSNP and Humsavar for SLC26A6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs387907493 Uncertain significance 48,627,047(-) GTGAG(C/T)TCAGG reference, synonymous-codon
rs387907494 Uncertain significance 48,628,696(-) GGGGG(A/C/G)TGAAG reference, missense
rs387907495 Uncertain significance 48,628,683(-) CTTCC(A/G)CTCCT reference, missense
rs387907496 Uncertain significance 48,631,921(-) TTGGC(A/C)TCCAT intron-variant, reference, missense
rs387907497 Uncertain significance 48,633,042(-) GTTTG(A/G)CCTCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SLC26A6 Gene

Variant ID Type Subtype PubMed ID
nsv954485 CNV deletion 24416366
nsv834685 CNV loss 17160897
nsv818138 CNV gain 17921354
nsv590247 CNV loss 21841781
nsv590246 CNV loss 21841781
nsv523981 CNV loss 19592680
esv3430072 CNV duplication 20981092
esv2725248 CNV deletion 23290073

Variation tolerance for SLC26A6 Gene

Residual Variation Intolerance Score: 49.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.40; 77.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC26A6 Gene

Human Gene Mutation Database (HGMD)
SLC26A6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC26A6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC26A6 Gene

Disorders for SLC26A6 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLC26A6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
diarrhea 1, secretory chloride, congenital
  • congenital chloride diarrhea
proximal renal tubular acidosis
  • renal tubular acidosis type 2
renal tubular acidosis
  • acidosis renal tubular
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC26A6

Genetic Association Database (GAD)
SLC26A6
Human Genome Epidemiology (HuGE) Navigator
SLC26A6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC26A6
genes like me logo Genes that share disorders with SLC26A6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC26A6 Gene

Publications for SLC26A6 Gene

  1. Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger. (PMID: 11087667) Lohi H. … Kere J. (Genomics 2000) 2 3 4 22 64
  2. Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family. (PMID: 11247665) Waldegger S. … Kubisch C. (Genomics 2001) 2 3 4 64
  3. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PMID: 19367581) So H.C. … Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  4. Analysis of the 206M polymorphic variant of the SLC26A6 gene encoding a Cl- oxalate transporter in patients with primary hyperparathyroidism. (PMID: 19029225) Corbetta S. … Spada A. (Eur. J. Endocrinol. 2009) 3 46 64
  5. Parsing apical oxalate exchange in Caco-2BBe1 monolayers: siRNA knockdown of SLC26A6 reveals the role and properties of PAT-1. (PMID: 20501439) Freel R.W. … Hatch M. (Am. J. Physiol. Gastrointest. Liver Physiol. 2009) 3 4 64

Products for SLC26A6 Gene

Sources for SLC26A6 Gene

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