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SLC26A6 Gene

protein-coding   GIFtS: 59
GCID: GC03M048664

Solute Carrier Family 26 (Anion Exchanger), Member 6

(Previous names: solute carrier family 26, member 6)
  See SLC26A6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 26 (Anion Exchanger), Member 61 2     Sulfate Anion Transporter1 2
Solute Carrier Family 26, Member 61 2     Anion Exchange Transporter2 3
Pendrin-Like Protein 11 3     Solute Carrier Family 26 Member 62
Anion Transporter 11 2     Pendrin-L13
Pendrin L11 2     

External Ids:    HGNC: 144721   Entrez Gene: 650102   Ensembl: ENSG000002256977   OMIM: 6100685   UniProtKB: Q9BXS93   

Export aliases for SLC26A6 gene to outside databases

Previous GC identifers: GC03M048453 GC03M047946 GC03M048482 GC03M048623 GC03M048639 GC03M048640


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC26A6 Gene:
This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This
particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate.
Alternatively spliced transcript variants encoding distinct isoforms have been described. (provided by RefSeq,
Aug 2013)

GeneCards Summary for SLC26A6 Gene:
SLC26A6 (solute carrier family 26 (anion exchanger), member 6) is a protein-coding gene. Diseases associated with SLC26A6 include acute urate nephropathy, and primary hyperoxaluria. GO annotations related to this gene include PDZ domain binding and secondary active sulfate transmembrane transporter activity. An important paralog of this gene is SLC26A9.

UniProtKB/Swiss-Prot: S26A6_HUMAN, Q9BXS9
Function: Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of
the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and
organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and
hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of
these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and
chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride
absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to
intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption,
possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate
secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion,
chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by
PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also
a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the
proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate
exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich
acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical
membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules
of kidney. Plays a role in sperm capacitation by increasing intracellular pH
Function: Isoform 4: Apical membrane chloride-bicarbonate exchanger. Its association with carbonic anhydrase CA2
forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the
transporter site

Gene Wiki entry for SLC26A6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC26A6 gene promoter:
         FOXO4   NRSF form 1   HNF-4alpha2   NRSF form 2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC26A6 promoter sequence
   Search Chromatin IP Primers for SLC26A6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC26A6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

SLC26A6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC26A6 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M048664:  view genomic region     (about GC identifiers)

Start:
48,663,156 bp from pter      End:
48,672,926 bp from pter
Size:
9,771 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S26A6_HUMAN, Q9BXS9 (See protein sequence)
Recommended Name: Solute carrier family 26 member 6  
Size: 759 amino acids; 82967 Da
Subunit: Interacts (via C-terminus domain) with PDZK1 (via C-terminal PDZ domain); the interaction induces
chloride and oxalate exchange transport. Interacts with CFTR, SLC26A3 and SLC9A3R1 (By similarity). Isoform 4
interacts (via C-terminus cytoplasmic domain) with CA2; the interaction stimulates chloride-bicarbonate exchange
activity. Isoform 4 and isoform 5 interact with SLC9A3R1 (via the PDZ domains). Isoform 4 and isoform 5 interact
with SLC9A3R2 (via the PDZ domains)
Secondary accessions: Q548A7 Q96Q90 Q9NQU1
Alternative splicing: 6 isoforms:  Q9BXS9-1   Q9BXS9-2   Q9BXS9-3   Q9BXS9-4   Q9BXS9-5   Q9BXS9-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC26A6: NX_Q9BXS9

Explore proteomics data for SLC26A6 at MOPED

Post-translational modifications: 

  • Phosphorylated on serine residues by PKC; the phosphorylation disrupts interaction with carbonic anhydrase CA2 and
    reduces bicarbonate transport activity in a phorbol myristate acetate (PMA)-induced manner1
  • Glycosylation2 at Asn167, Asn172
  • Modification sites at PhosphoSitePlus

  • See SLC26A6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001035544.1  NP_001268661.1  NP_001268662.1  NP_075062.2  NP_599025.2  NP_602298.2  

    ENSEMBL proteins: 
     ENSP00000404684   ENSP00000378920   ENSP00000373239   ENSP00000307089   ENSP00000337648  
     ENSP00000401066   ENSP00000389922   ENSP00000404607   ENSP00000388721   ENSP00000387532  
     ENSP00000401813   ENSP00000405872   ENSP00000351597  
    Reactome Protein details: Q9BXS9

    SLC26A6 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: PAT-1
    Chloride/bicarbonate exchangers

    4 InterPro protein domains:
     IPR002645 STAS_dom
     IPR018045 S04_transporter_CS
     IPR001902 SulP_transpt
     IPR011547 Sulph_transpt

    Graphical View of Domain Structure for InterPro Entry Q9BXS9

    ProtoNet protein and cluster: Q9BXS9

    1 Blocks protein domain: IPB001902 Sulphate transporter

    UniProtKB/Swiss-Prot: S26A6_HUMAN, Q9BXS9
    Similarity: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family
    Similarity: Contains 1 STAS domain


    Find genes that share domains with SLC26A6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S26A6_HUMAN, Q9BXS9
    Function: Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of
    the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and
    organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and
    hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of
    these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and
    chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride
    absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to
    intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption,
    possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate
    secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion,
    chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by
    PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also
    a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the
    proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate
    exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich
    acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical
    membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules
    of kidney. Plays a role in sperm capacitation by increasing intracellular pH
    Function: Isoform 4: Apical membrane chloride-bicarbonate exchanger. Its association with carbonic anhydrase CA2
    forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the
    transporter site
    Enzyme regulation: Apical membrane chloride-formate exchange activity in the proximal tubules of the kidney and
    oxalate secretion in the duodenum are inhibited by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an
    inhibitor of several anion channels and transporters) (By similarity). Apical membrane chloride-bicarbonate
    exchange activity of the pancreatic duct is inhibited by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS
    - an inhibitor of several anion channels and transporters). Isoform 4, isoform 5 and isoform 6 chloride,
    bicarbonate and sulfate transport activities are inhibited by DIDS
    Induction: Down-regulated by pro-inflammatory cytokine IFN gamma

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005254chloride channel activity IEA--
    GO:0005515protein binding IPI12444019
    GO:0008271secondary active sulfate transmembrane transporter activity IEA--
    GO:0015106bicarbonate transmembrane transporter activity ISS--
    GO:0015108chloride transmembrane transporter activity ISS--
         
    Find genes that share ontologies with SLC26A6           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SLC26A6:
     Decreased viability  Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Slc26a6):
     digestive/alimentary  endocrine/exocrine gland  homeostasis/metabolism  renal/urinary system 

    Find genes that share phenotypes with SLC26A6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SLC26A6: Slc26a6tm1Psar Slc26a6tm1Sole Slc26a6tm1Smua

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC26A6
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    miRNA
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    hsa-miR-544b hsa-miR-125a-5p hsa-miR-125b hsa-miR-4309 hsa-miR-4294 hsa-miR-1289 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidSLC26A6 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S26A6_HUMAN, Q9BXS9: Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Apical
    cell membrane; Multi-pass membrane protein (By similarity). Cytoplasmic vesicle membrane; Multi-pass membrane
    protein (By similarity). Microsome (By similarity). Note=Localized in sperm membranes. Colocalizes with CFTR at
    the midpiece of sperm tail. Localizes to the apical membrane brush border of epithelial cells in the proximal
    tubules of kidney, of enterocytes of the small intestine and of gastric parietal cells in the stomach. May be
    translocated from the cytosolic surface of the cell membrane to the intracellular space by PKC in phorbol
    myristate acetate (PMA)-induced cells (By similarity). Colocalized with CA2 at the surface of the cell membrane
    in order to form a bicarbonate transport metabolon; colocalization is reduced in phorbol myristate acetate
    (PMA)-induced cells
    S26A6_HUMAN, Q9BXS9: Isoform 4: Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass
    membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Localizes to the apical and
    basolateral surfaces of tubular wall cells in kidney and in the brush border of pancreatic duct cells
    S26A6_HUMAN, Q9BXS9: Isoform 5: Cell membrane; Multi-pass membrane protein
    S26A6_HUMAN, Q9BXS9: Isoform 6: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane ----
    GO:0012506vesicle membrane ISS--
    GO:0016020membrane ISS--

    Find genes that share ontologies with SLC26A6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC26A6 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Multifunctional anion exchangers0.00
    2Mineral absorption
    Mineral absorption


    Find genes that share SuperPaths with SLC26A6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC26A6
        Multifunctional anion exchangers


    1 Kegg Pathway  (Kegg details for SLC26A6):
        Mineral absorption

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC26A6
    Interactions:

        GeneGlobe Interaction Network for SLC26A6

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for SLC26A6 (Q9BXS93 ENSP000003789204) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDZK1Q5T2W13, ENSP000003421434I2D: score=1 STRING: ENSP00000342143
    UBCENSP000003448184STRING: ENSP00000344818
    NDUFAB1ENSP000000075164STRING: ENSP00000007516
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006820anion transport IDA12444019
    GO:0006821chloride transport IMP--
    GO:0008272sulfate transport ISS--
    GO:0015701bicarbonate transport IMP--

    Find genes that share ontologies with SLC26A6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC26A6 (S26A6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC26A6 gene (6 alternative transcripts): 
    NM_001040454.1  NM_001281732.1  NM_001281733.1  NM_022911.2  NM_134263.2  NM_134426.2  

    Unigene Clusters for SLC26A6:

    Solute carrier family 26, member 6
    Hs.631925  [show with all ESTs], Hs.663208  [show with all ESTs]
    Unigene Representative Sequences: NM_001040454, AF150415
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000420764(uc011bbp.2 uc003cuh.3 uc003cui.3) ENST00000489483
    ENST00000395550 ENST00000383733(uc003cuj.3) ENST00000307364(uc010hke.3)
    ENST00000337000(uc003cuk.3) ENST00000480524 ENST00000455886 ENST00000466257
    ENST00000462009 ENST00000469693 ENST00000496469 ENST00000421649 ENST00000444531
    ENST00000414944 ENST00000485361 ENST00000494717 ENST00000482282
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC26A6
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    Additional mRNA sequence: AF161369.1 

    16 DOTS entries:

    DT.114485  DT.100814279  DT.100745852  DT.75102906  DT.302991  DT.99994018  DT.120910990  DT.100649110 
    DT.120911034  DT.92425765  DT.100008831  DT.100024321  DT.100668200  DT.75194168  DT.92425760  DT.305126 

    Selected AceView cDNA sequences (see all 154):

    BF983692 CF131391 BM824090 BU732256 AA779900 BU854979 BQ681565 AA324420 
    AW206043 AF279265 NM_022911 AW236215 BM782886 AF288410 BM703189 BU848723 
    BM709189 BC017697 AB033288 AI560657 BF366213 BE217837 NM_134263 BM981593 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC26A6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTCAGGCT
    SLC26A6 Expression
    About this image

    SLC26A6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC26A6 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.631925 Hs.663208

    UniProtKB/Swiss-Prot: S26A6_HUMAN, Q9BXS9
    Tissue specificity: Ubiquitous. Highest levels in kidney and pancreas. Lower expression in heart, skeletal muscle,
    liver and placenta. Also found in lung and brain. Isoform 4 is ubiquitously expressed. Isoform 6 is expressed in
    heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis and ovary. Isoform 5 is
    expressed weakly in placenta, lung, liver and pancreas

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC26A6 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc26a61 , 5 solute carrier family 26, member 61, 5 81.04(n)1
    78.37(a)1
      9 (59.63 cM)5
    1714291  NM_134420.41  NP_599252.21 
     1088540375 
    chicken
    (Gallus gallus)
    Aves SLC26A61 solute carrier family 26, member 6 65.19(n)
    60.49(a)
      416012  NM_001252254.1  NP_001239183.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC26A66
    solute carrier family 26 (anion exchanger), member...
    55(a)
    1 ↔ 1
    2(164375606-164409228)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.54312 Xenopus laevis transcribed sequence with weak similarity more 73.01(n)    CA792851.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc26a61 solute carrier family 26, member 6 57.18(n)
    51.75(a)
      100005108  XM_001344207.4  XP_001344243.4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SULTR4;21 SULTR4;2 42.33(n)
    32.12(a)
      820431  NM_112087.2  NP_187858.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g02405001 Os09g0240500 42.68(n)
    31.42(a)
      4346475  NM_001069179.1  NP_001062644.1 


    ENSEMBL Gene Tree for SLC26A6 (if available)
    TreeFam Gene Tree for SLC26A6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC26A6 gene
    SLC26A92  SLC26A32  SLC26A12  SLC26A52  SLC26A112  SLC26A22  SLC26A102  SLC26A72  
    SLC26A42  SLC26A82  
    14 SIMAP similar genes for SLC26A6 using alignment to 11 protein entries:     S26A6_HUMAN (see all proteins):
    DKFZp586E1422    RESDA1    SLC26A11    SLC26A7    SLC26A4    SLC26A10
    SLC26A2    SLC26A5    SLC26A3    DKFZp686P10213    PRES    SLC26A9
    SLC26A8    SLC26A1

    Find genes that share paralogs with SLC26A6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC26A6 (see all 307)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1871645971,2
    --48662716(+) TCCACC/TTGCCT 4 -- ds50010--------
    rs1915455991,2
    --48662762(+) CACCGC/TGCCCG 4 -- ds50010--------
    rs1833122911,2
    --48662887(+) CTTCTC/TGGGTA 4 -- ds50010--------
    rs1868461151,2
    --48662888(+) TTCTCA/GGGTAT 4 -- ds50010--------
    rs1403311711,2
    C--48662910(+) AATTAC/TTCCTG 4 -- ds50010--------
    rs76315741,2
    C,F,A,H--48663046(+) GAGTCC/TTTCCT 4 -- ds500124Minor allele frequency- T:0.27NS EA NA WA CSA 2350
    rs1898091701,2
    --48663066(+) GCCCCA/GTCTCA 4 -- ds50010--------
    rs578271371,2
    F--48663128(+) CAGGGA/CCCCAC 4 -- ds50010--------
    rs1820842171,2
    --48663167(+) AGACAA/GATCTT 4 -- ut310--------
    rs1388647521,2
    --48663215(+) GTACCA/GCGCCA 4 -- ut310--------

    HapMap Linkage Disequilibrium report for SLC26A6 (48663156 - 48672926 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SLC26A6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725248CNV Deletion23290073
    nsv876762CNV Loss21882294
    nsv834685CNV Loss17160897
    nsv876763CNV Loss21882294
    nsv523981CNV Loss19592680
    nsv818138CNV Gain17921354

    Human Gene Mutation Database (HGMD): SLC26A6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC26A6
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC26A6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610068    OMIM disorders: --

    3 diseases for SLC26A6:    
    About MalaCards
    acute urate nephropathy    primary hyperoxaluria    primary hyperparathyroidism

    5 diseases from the University of Copenhagen DISEASES database for SLC26A6:
    Primary hyperoxaluria     Nephrolithiasis     Cystic fibrosis     Diastrophic dysplasia
    Acute urate nephropathy

    Find genes that share disorders with SLC26A6           About GenesLikeMe

    Genetic Association Database (GAD): SLC26A6
    Human Genome Epidemiology (HuGE) Navigator: SLC26A6 (3 documents)

    Export disorders for SLC26A6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC26A6 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with SLC26A6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger. (PubMed id 11087667)1, 2, 3, 9 Lohi H....Kere J. (Genomics 2000)
    2. Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family. (PubMed id 11247665)1, 2, 3 Waldegger S....Kubisch C. (Genomics 2001)
    3. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    4. Analysis of the 206M polymorphic variant of the SLC26A6 gene encoding a Cl- oxalate transporter in patients with primary hyperparathyroidism. (PubMed id 19029225)1, 4 Corbetta S....Spada A. (Eur. J. Endocrinol. 2009)
    5. Parsing apical oxalate exchange in Caco-2BBe1 monolayers: siRNA knockdown of SLC26A6 reveals the role and properties of PAT-1. (PubMed id 20501439)1, 2 Freel R.W....Hatch M. (Am. J. Physiol. Gastrointest. Liver Physiol. 2009)
    6. Characterization of the 5'-flanking region and regulation of expression of human anion exchanger SLC26A6. (PubMed id 18655181)1, 2 Saksena S....Dudeja P.K. (J. Cell. Biochem. 2008)
    7. Phenotypic and functional analysis of human SLC26A6 variants in patients with familial hyperoxaluria and calcium oxalate nephrolithiasis. (PubMed id 18951670)1, 4 Monico C.G....Aronson P.S. (Am. J. Kidney Dis. 2008)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. Metabolon disruption: a mechanism that regulates bicarbonate transport. (PubMed id 15990874)1, 2 Alvarez B.V....Casey J.R. (EMBO J. 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 65010 HGNC: 14472 AceView: COL7A1.1 Ensembl:ENSG00000225697 euGenes: HUgn65010
    ECgene: SLC26A6 Kegg: 65010 H-InvDB: SLC26A6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC26A6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC26A6 gene:
    Search GeneIP for patents involving SLC26A6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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