SLC26A5 Gene
protein-coding GIFtS: 50
GCID: GC07M102993
|
|
solute carrier family 26, member 5 (prestin)(Previous name: prestin (motor protein) )
(Previous symbol: PRES)
| |
Aliases
for SLC26A5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 26, Member 5 (Prestin)1 2 | | PRES1 2 3 5 | | DFNB611 2 5 | | Prestin (Motor Protein)1 2 | | Prestin1 | | Solute Carrier Family 26 Member 53 |
Export aliases for SLC26A5 gene to outside databasesPrevious GC identifers: GC07M102588 GC07M102780 GC07M097355 |
Summaries
for SLC26A5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLC26A5:
This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motileouter hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. Thetransmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane butinstead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a changein cell length. The protein functions at microsecond rates, which is several orders of magnitude faster thanconventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensorydeafness. Multiple transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq,Nov 2009)
UniProtKB/Swiss-Prot: S26A5_HUMAN, P58743Function: Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates soundamplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate atmicrosecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. Afterbinding to a site with millimolar affinity, these anions are translocated across the membrane in response to changesin the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards thecytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changesin the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when theanion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membraneto the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, butdoes not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outerhair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity)
Gene Wiki entry for SLC26A5 (Prestin)
|
Genomic Views
for SLC26A5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC26A5 gene promoter:
RFX1 Nkx2-2 Pax-6 HSF1 (long) Lmo2 GATA-1 MZF-1 FOXJ2 (long isoform) HSF2 HSF1short
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC26A5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC26A5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22SLC26A5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M102993: view genomic region
(about GC identifiers)
Start:
|
102,993,177 bp from pter |
End:
|
103,086,624 bp from pter |
Size:
|
93,448 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 102,353,543-102,447,443 |
|
Proteins
for SLC26A5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S26A5_HUMAN, P58743 (See
protein sequence)Recommended Name: Prestin Size: 744 amino acids; 81264 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity). Note=Lateral wall of outer hair cells(By similarity)
Secondary accessions: Q496J2 Q86UF8 Q86UF9 Q86UG0Alternative splicing: 5 isoforms: P58743-1 P58743-2 P58743-3 P58743-4 P58743-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SLC26A5: NX_P58743
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P58743
SLC26A5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001161434.1 NP_945350.1 NP_996766.1 NP_996767.1 NP_996768.1
ENSEMBL proteins: ENSP00000342396 ENSP00000349210 ENSP00000377336 ENSP00000304783 ENSP00000396833 ENSP00000416502 ENSP00000377331 ENSP00000389018 ENSP00000395568 ENSP00000377330 ENSP00000377328 ENSP00000377324 ENSP00000389733 ENSP00000346325
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- | | GO:0016323 | basolateral plasma membrane |
IEA | -- | | GO:0016328 | lateral plasma membrane |
IEA | -- |
SLC26A5 for ontologies About GeneDecksing
SLC26A5 Antibody Products:
Assay Products for SLC26A5: |
Protein
Domains /
Families
for SLC26A5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC26A5 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P58743ProtoNet protein and cluster: P58743 1 Blocks protein family: IPB001902 Sulphate transporter
UniProtKB/Swiss-Prot: S26A5_HUMAN, P58743Similarity: Belongs to the SLC26A/SulP transporter (TC 2.A.53) familySimilarity: Contains 1 STAS domain |
Function
for SLC26A5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: S26A5_HUMAN, P58743Function: Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates soundamplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate atmicrosecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. Afterbinding to a site with millimolar affinity, these anions are translocated across the membrane in response to changesin the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards thecytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changesin the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when theanion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membraneto the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, butdoes not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outerhair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC26A5 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC26A5 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC26A5 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008271 | secondary active sulfate transmembrane transporter activity |
IEA | -- | | GO:0015116 | sulfate transmembrane transporter activity |
-- | -- | | GO:0030507 | spectrin binding |
IEA | -- |
SLC26A5 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Slc26a5tm1Jnz for SLC26A5
3 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Slc26a5):
SLC26A5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SLC26A5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC26A5
1 Interacting protein for SLC26A5 (P587433) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
SLC26A5 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC26A5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SLC26A5 for compounds About GeneDecksing
 Browse Tocris compounds for SLC26A5
2 HMDB Compounds for SLC26A5 About this table
10/12 Novoseek chemical compound relationships for SLC26A5 gene (see all 12) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| salicylic acid |
57.2 |
16 |
18560754 (4), 20388516 (2), 18225604 (1), 13679136 (1) (see all 7) |
| chloride |
47.2 |
9 |
15596517 (2), 11247665 (1), 15720248 (1), 11423665 (1) (see all 7) |
| sulfate |
35 |
4 |
17151276 (2), 15720248 (1), 11914518 (1) |
| bicarbonate |
32.1 |
6 |
15720248 (1), 11423665 (1), 17120772 (1), 11914518 (1) (see all 5) |
| oxalate |
30.6 |
3 |
15720248 (1), 11087667 (1) |
| fructose |
22.7 |
2 |
15720248 (1), 17120761 (1) |
| mifepristone |
20.9 |
2 |
9528977 (1) |
| iodide |
20.5 |
1 |
15720248 (1) |
| formate |
12.6 |
1 |
15720248 (1) |
| lipid |
0 |
4 |
17321873 (1), 19517190 (1) |
Search CenterWatch for drugs/clinical trials and news about SLC26A5 / S26A5
|
Transcripts
for SLC26A5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC26A5 gene (5 alternative transcripts): NM_001167962.1 NM_198999.2 NM_206883.2 NM_206884.2 NM_206885.2 Unigene Cluster for SLC26A5: Solute carrier family 26, member 5 (prestin) Hs.585146 [show with all ESTs]Unigene Representative Sequence: NM_19899915 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000339444(uc003vbt.2) ENST00000356767(uc003vbv.2) ENST00000393735(uc003vbu.2)
ENST00000306312(uc003vbw.3 uc003vby.3 uc010liy.3 uc003vbz.3 uc003vbx.3)
ENST00000445809 ENST00000454864 ENST00000393730 ENST00000423416 ENST00000456463
ENST00000393729 ENST00000393727 ENST00000393723 ENST00000487407 ENST00000432958
ENST00000354356
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC26A5 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC26A5 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 5): SLC26A5 (NM_206883) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC26A5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC26A5 |
Additional cDNA sequence: AF523354.1 AK126898.1 AY256823.1 AY256824.1 AY256825.1 AY289133.1 AY289134.1 BC100833.1 BC100834.1 5 DOTS entries: DT.100700749 DT.100741432 DT.100741433 DT.95290143 DT.100681889 13 AceView cDNA sequences: NM_206883 NM_206884 NM_198999 AF523354 AY256825 AY256824 AY256823 NM_206885 BX493225 AK126898 AY289133 AY289134 AW866709
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A5 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SLC26A5
|
Expression
for SLC26A5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC26A5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAAAATATC
About this image
See SLC26A5 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.585146
SABiosciences Custom PCR Arrays for SLC26A5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC26A5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC26A5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC26A5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC26A5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC26A5 |
Orthologs
for SLC26A5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC26A5 gene from 8/25 species (see all 25) About this table
ENSEMBL Gene Tree for SLC26A5 (if available)
TreeFam Gene Tree for SLC26A5 (if available) |
Paralogs
for SLC26A5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC26A5 gene
- SLC26A92 SLC26A32 SLC26A102 SLC26A72 SLC26A62 SLC26A42 SLC26A12 SLC26A22
- SLC26A112 SLC26A82
12 SIMAP similar genes for SLC26A5 using alignment to 7 protein entries: S26A5_HUMAN (see all proteins):PRES RESDA1 SLC26A7 SLC26A6 SLC26A4 DKFZp686P10213
SLC26A3 SLC26A9 SLC26A1 SLC26A10 SLC26A2 SLC26A11
SLC26A5 for paralogs About GeneDecksing
|
Genomic Variants
for SLC26A5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC26A5 (102993177 - 103086624 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC26A5: --
Human Gene Mutation Database (HGMD): SLC26A5
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC26A5 |
|
Disorders
/ Diseases
for SLC26A5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC26A5 for disorders About GeneDecksing
OMIM gene information: 604943
OMIM disorders: --
UniProtKB/Swiss-Prot: S26A5_HUMAN, P58743
Defects in SLC26A5 are the cause of deafness autosomal recessive type 61 (DFNB61) [MIM:613865]. A form ofnon-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of theinner ear, the nerve pathways to the brain, or the area of the brain that receives sound information
20/23  diseases for SLC26A5 (see all 23): About MalaCardsdeafness, autosomal recessive 61 diastrophic dysplasia pendred syndrome hearing loss
cortical blindness atelosteogenesis achondrogenesis hepatitis b
fainting blindness brain disease eclampsia
hepatocellular carcinoma pharyngitis hepatitis cholesterol
tuberculosis thyroiditis carcinoma pancreatitis
5 diseases from the University of Copenhagen DISEASES database for SLC26A5:Sensorineural hearing loss Diastrophic dysplasia Nonsyndromic deafness Atelosteogenesis
Achondrogenesis 4 Novoseek disease relationships for SLC26A5 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| diastrophic dysplasia |
71.3 |
1 |
11247665 (1) |
| pendred syndrome |
68 |
1 |
11247665 (1) |
| ototoxicity |
54.7 |
1 |
17970566 (1) |
| hepatitis b |
34.9 |
6 |
8995631 (2), 9148003 (1), 17608857 (1) |
Genetic Association Database (GAD): SLC26A5
Human Genome Epidemiology (HuGE) Navigator: SLC26A5 (5 documents)
Export disorders for SLC26A5 gene to outside databases
|
Publications
for SLC26A5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC26A5 gene, integrated from 9 sources (see all 123):
(articles sorted by number of sources associating them with SLC26A5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss. (PubMed id 12719379)1, 2, 9 Liu X.Z.... Chen Z.-Y. (2003)
- Prestin is the motor protein of cochlear outer hair cells. (PubMed id 10821263)1, 3, 9 Zheng J....Dallos P. (2000)
- High frequency of the IVS2-2A>G DNA sequence variation in SLC26A5, encoding the cochlear motor protein prestin, precludes its involvement in hereditary hearing loss. (PubMed id 16086836)1, 4, 9 Tang H.Y....Alford R.L. (2005)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- DNA sequence analysis of SLC26A5, encoding prestin, i n a patient-control cohort: identification of fourteen novel DNA sequence varia tions. (PubMed id 19492055)1, 9 Minor J.S....Alford R.L. (2009)
- Cysteine mutagenesis reveals transmembrane residues a ssociated with charge translocation in prestin. (PubMed id 19926791)1, 9 McGuire R.M....Raphael R.M. (2010)
- A new mutation in the human pres gene and its effect on prestin function. (PubMed id 17786286)1, 9 Toth T....Sziklai I. (2007)
- Essential helix interactions in the anion transporter domain of prestin revealed by evolutionary trace analysis. (PubMed id 17151276)1, 9 Rajagopalan L....Pereira F.A. (2006)
- N-linked glycosylation sites of the motor protein prestin: effects on membrane targeting and electrophysiological function. (PubMed id 15140192)1, 9 Matsuda K....Dallos P. (2004)
- Splice variant IVS2-2A>G in the SLC26A5 (Prestin) gene in five Estonian families with hearing loss. (PubMed id 19027966)1, 9 Teek R....Ounap K. (2009)
|
External Searches for SLC26A5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC26A5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC26A5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC26A5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for SLC26A5 | Pharmacogenomics, SNPs, Pathways | | Protein Spotlight | http://web.expasy.org/spotlight/back_issues/sptlt022.shtml |
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About This Section
| Patent Information for SLC26A5 gene:
Search GeneIP for patents involving SLC26A5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SLC26A5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLC26A5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC26A5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC26A5 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLC26A5 | | OriGene 3'-UTR Clone for SLC26A5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC26A5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC26A5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SLC26A5 | | OriGene Custom Protein Services for SLC26A5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC26A5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC26A5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC26A5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC26A5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC26A5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC26A5 |
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| | | | Search Tocris compounds for SLC26A5 |
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 | | | SLC26A5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC26A5 |
|  |  |  | | | | Search ThermoFisher Antibodies for SLC26A5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC26A5 |
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