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SLC26A4 Gene

protein-coding GIFtS: 59

GC07P107088

solute carrier family 26, member 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: DFNB4)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
DFNB4 ^², ⁵
EVA ^², ⁵
PDS ^¹, ², ³, ⁵
pendrin ^²

Descriptions
Sodium-independent chloride/iodide transporter ^³
Solute carrier family 26 member 4 ^³
solute carrier family 26, member 4 ^²

External Ids
HGNC: 8818¹
Entrez Gene: 5172²
UniProtKB: O43511³
Ensembl: ENSG00000091137⁷

Search outside databases for aliases for SLC26A4 gene

Previous GC identifers: GC07P105784 GC07P106847 GC07P106861 GC07P106895

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SLC26A4:

Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic

deafness, an autosomal-recessive disease. It is highly homologous to the SLC26A3 gene; they have

similar genomic structures and this gene is located 3' of the SLC26A3 gene. The encoded

protein has homology to sulfate transporters. [provided by RefSeq]

UniProtKB/Swiss-Prot: S26A4_HUMAN, O43511

Function: Sodium-independent transporter of chloride and iodide

Gene Wiki entry for SLC26A4 (Pendrin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SLC26A4 gene

Entrez Gene cytogenetic band: 7q31 Ensembl cytogenetic band: 7q22.3 HGNC cytogenetic band: 7q31

SLC26A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P107088: (about GC identifiers)

Start:	107,088,316 bp from pter
End:	107,145,490 bp from pter
Size:	57,175 bases
Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 106,662,192-106,719,369

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079596.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: S26A4_HUMAN, O43511 (See protein sequence)

Recommended Name: Pendrin

Size: 780 amino acids; 85723 Da

Subcellular location: Membrane; Multi-pass membrane protein (Probable)

Secondary accessions: O43170

REFSEQ proteins: NP_000432.1

ENSEMBL proteins:

ENSP00000265715

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (SLC26A4)
	Human Recombinant Proteins from Abnova (SLC26A4)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	TAS	10192399

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Antibodies for SLC26A4:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for SLC26A4
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (SLC26A4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SLC26A4)
	Novus Biologicals Antibodies for SLC26A4

Assays for SLC26A4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O43511

ProtoNet protein and cluster: O43511

1 Blocks protein family: IPB001902 Sulphate transporter

UniProtKB/Swiss-Prot: S26A4_HUMAN, O43511

Similarity: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family

Similarity: Contains 1 STAS domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SLC26A4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SLC26A4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000441

Applied Biosystems Silencer® siRNAs for SLC26A4

Sigma-Aldrich siRNA and siRNA Panels for SLC26A4

Sigma-Aldrich shRNA for SLC26A4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000441
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000441
untagged cDNA clone in CMV expression vector: NM_000441

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000441

UniProtKB/Swiss-Prot: S26A4_HUMAN, O43511

Function: Sodium-independent transporter of chloride and iodide

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Slc26a4):

behavior/neurological	endocrine/exocrine gland	hearing/vestibular/ear	homeostasis/metabolism	nervous system
pigmentation	reproductive system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	IEA	--
GO:0008271	secondary active sulfate transmembrane transporter activity	IEA	--
GO:0015108	chloride transmembrane transporter activity	TAS	10192399
GO:0015111	iodide transmembrane transporter activity	TAS	10192399
GO:0031404	chloride ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for SLC26A4

5/15 Interacting proteins for SLC26A4 (ENSP00000265715³) via UniProtKB, MINT, and/or STRING (see all 15 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FOXI1	ENSP00000304286³	STRING (score=.99)
MPZL2	ENSP00000278937³	STRING (score=.958)
SLC5A5	ENSP00000222248³	STRING (score=.953)
TG	ENSP00000220616³	STRING (score=.945)
TPO	ENSP00000329869³	STRING (score=.945)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	IEA	--
GO:0007605	sensory perception of sound	TAS	9398842 10192399
GO:0008272	sulfate transport	TAS	9398842

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SLC26A4
10/16 Novoseek chemical compound relationships for SLC26A4 gene (see all 16 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
iodide	91.65	134	14715652 (9), 15155570 (5), 11932316 (3), 19196800 (3) (see all 53)
sodium iodide	84.99	21	19050049 (2), 11575851 (2), 11932316 (1), 19014326 (1) (see all 12)
perchlorate	82.49	9	15279074 (3), 10602116 (1), 17697873 (1), 11700190 (1) (see all 6)
iodine	71.11	12	18283249 (2), 15858240 (1), 17940114 (1), 9920104 (1) (see all 6)
chloride	65.05	65	15155570 (5), 10644529 (4), 16260428 (3), 16914891 (2) (see all 30)
sulfate	55.72	26	10192399 (4), 10803474 (4), 9398842 (3), 11573133 (1) (see all 12)
sodium	47.55	19	11454507 (2), 11720877 (2), 16042141 (1), 17381352 (1) (see all 13)
bicarbonate	37.31	11	11274445 (3), 15720248 (1), 18322141 (1), 11919333 (1) (see all 6)
thiocyanate	26.38	1	17404297 (1)
oxalate	24.08	1	15720248 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SLC26A4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SLC26A4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000441

Sigma-Aldrich siRNA and siRNA Panels for SLC26A4

Sigma-Aldrich shRNA for SLC26A4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000441

REFSEQ mRNAs for SLC26A4 gene:

NM_000441.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000441

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000441
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000441
                                 untagged cDNA clone in CMV expression vector: NM_000441

Additional cDNA sequence:

AF030880.1 AK294388.1 AK298543.1 AK300604.1

2 DOTS entries:

DT.408690 DT.102821049

19 AceView cDNA sequences:

CA945256 AF030880 AI139968 NM_000441 BX486815 AI695233 BX953700 BX487622

BG718763 AI286141 CB986316 AA385554 AU117234 AU144128 AA897348 AA653057

H23053 AW891838 BI005285

highest scoring ESTs for SLC26A4:

AF030880 AA385554 AA653057 AI139968 AI695233 AU117234 AU144128 AW891838 BX487622 CA945256

Unigene Cluster for SLC26A4:

Solute carrier family 26, member 4

Hs.571246 [show with all ESTs]

Unigene Representative Sequence: NM_000441

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000265715

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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SLC26A4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SLC26A4

¹ / ² / ³

3 probe-sets matching SLC26A4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36376_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AF030880	1.00	1.00	1.00	1
206529_x_at²^{, 3}	U133-A	29	1.00	0.91	--	--	NM_000441	0.60	1.00	0.82	1
206529_x_at²	U133Plus2	29	1.00	0.91	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.571246
Expression variation in blood from EXPOLDB for SLC26A4
UniProtKB/Swiss-Prot: S26A4_HUMAN, O43511
Tissue specificity: High expression in adult thyroid, lower expression in adult and fetal kidney
and fetal brain. Not expressed in other tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SLC26A4 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SLC26A4¹	--	solute carrier family 26, member 4	88.7(n) 89.99(a)	483263 XM_540382.2 XP_540382.2
chimpanzee (Pan troglodytes)	SLC26A4¹	--	solute carrier family 26, member 4	99.27(n) 99.1(a)	463654 XM_519308.2 XP_519308.2
cow (Bos taurus)	SLC26A4¹	--	solute carrier family 26, member 4	88.66(n) 88.75(a)	530241 XM_608706.3 XP_608706.3
rat (Rattus norvegicus)	Slc26a4¹	--	solute carrier family 26, member 4	85.04(n) 88.72(a)	29440 NM_019214.1 NP_062087.1
mouse (Mus musculus)	Slc26a4^{1, 5}	12 (15.00 cM)⁵	solute carrier family 26, member 4^{1, 5}	85.43(n)¹ 87.56(a)¹	23985¹ NM_011867.2¹ NP_035997.1¹ AF167411⁵ BC140995⁵

About this table Species with no ortholog for SLC26A4

ENSEMBL Gene Tree for SLC26A4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SLC26A4 gene

SLC26A9² SLC26A3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/94 NCBI SNPs in SLC26A4 are shown (see all 94 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 119)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2712218^1,2	C,F,H,O	107143995(-)	`ATTTTC/TACTCA`	1	--	ut3¹		13	EU EA WA NA	2514
	rs17154353^1,2	C,F,H	107137863(+)	`GTCAAG/AGTTCC`	1	S/G	mis¹		11	NA EU EA WA	978
	rs17154335^1,2	C,F,H	107129530(+)	`TGCTGT/GTTCAA`	1	G/V	mis¹ ese³		12	NA EU EA WA	1056
	rs35548413^1,2	C,F	107132036(+)	`GAATTG/TATGTG`	1	D/Y	mis¹		5	NA EU EA WA	470
	rs2712205^1,2	H	107144644(-)	`GAATTC/GAGGAT`	1	--	ut3¹ ese³		4	EU EA WA	410
	rs17154347^1,2	C,F,H	107137775(+)	`TTTGAC/TGACAA`	1	D/D	syn¹ ese³		8	NA EU EA WA	636
	rs982915^1,2	A,C,F,H,O	107127147(+)	`GGAGGA/GTCAGT`	1	--	int¹		13	NA EA MN EU WA	981
	rs982663^1,2	A,C,F,H,O	107131269(+)	`GTTCAG/ATGAAT`	1	--	int¹		16	NA EA MN EU WA	1456
	rs6466178^1,2	A,C,F,H	107135032(+)	`ttccaT/Acgaat`	1	--	int¹		7	EU EA WA NA	556
	rs2712208^1,2	A,C,F,H	107130998(-)	`AGTCAG/CCTTTA`	1	--	int¹		4	EU EA WA	420

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HapMap Linkage Disequilibrium images for SLC26A4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605646 disorders: 274600 600791

UniProtKB/Swiss-Prot: S26A4_HUMAN, O43511

Defects in SLC26A4 are a cause of Pendred syndrome (PDS) [MIM:274600]. PDS is an autosomal

recessive disorder characterized by congenital sensorineural hearing loss combined with thyroid

goiter. The disorder may account for up to 10% of the cases of hereditary deafness. The deafness

is most often associated with a Mondini cochlear defect

Defects in SLC26A4 are the cause of non-syndromic sensorineural deafness autosomal

recessive type 4 (DFNB4) [MIM:600791]; also known as vestibular aqueduct syndrome (EVA). DFNB4 is

a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural

receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that

receives sound information. DFNB4 is associated with an enlarged vestibular aqueduct

10/34 Novoseek disease relationships for SLC26A4 gene (see all 34 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
pendred syndrome	99.18	149	9920104 (4), 12788906 (4), 11573133 (3), 10037079 (3) (see all 80)
dfnb4	93.93	11	18285825 (2), 10861298 (2), 10868226 (1), 11101839 (1) (see all 8)
enlarged vestibular aqueduct syndrome	92.11	5	17886676 (1), 10861298 (1), 11905055 (1), 18067822 (1)
goiter	87.97	30	9920104 (3), 16914891 (2), 15279074 (2), 16791000 (2) (see all 20)
ear malformation	86.97	26	18167283 (2), 19040761 (2), 18538122 (1), 18585793 (1) (see all 7)
hearing loss sensorineural	84.90	22	16914891 (2), 11919333 (2), 18067822 (2), 18641518 (1) (see all 13)
deafness sensorineural	83.93	5	19196800 (1), 17659500 (1), 15279074 (1), 12642503 (1)
congenital deafness	83.24	7	17886676 (2), 10602116 (1), 10644505 (1), 18051563 (1) (see all 5)
goiter congenital	68.34	1	16042141 (1)
diastrophic dysplasia	66.79	2	10192399 (1), 11834742 (1)

About this table

GeneTests: SLC26A4

Pendred Syndrome/DFNB4

Human Gene Mutation Database: SLC26A4
Genetic Association Database: SLC26A4
Human Genome Epidemiology Navigator: SLC26A4 (23 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/203 PubMed articles for SLC26A4 gene (see all 203 ):

A novel mutation in the pendrin gene associated with Pendred's syndrome. (PubMed id 10718825)^{1, 3, 4, 6} Bogazzi F....Bartalena L. (2000)
A mutation in PDS causes non-syndromic recessive deafness. (PubMed id 9500541)^{2, 3, 4} Li X.C.... Wilcox E.R. (1998)
Distribution and frequencies of PDS (SLC26A4) mutations in Pendred syndrome and nonsyndromic hearing loss associated with enlarged vestibular aqueduct: a unique spectrum of mutations in Japanese. (PubMed id 14508505)^{1, 3, 4} Tsukamoto K.... Usami S. (2003)
Differential diagnosis between Pendred and pseudo-Pendred syndromes: clinical, radiologic, and molecular studies. (PubMed id 11919333)^{1, 3, 4} Fugazzola L.... Beck-Peccoz P. (2002)
Mutations in the SLC26A4 (pendrin) gene in patients with sensorineural deafness and enlarged vestibular aqueduct. (PubMed id 15279074)^{1, 3, 6} Bogazzi F....Martino E. (2004)
Enlarged vestibular aqueduct: a radiological marker of Pendred syndrome, and mutation of the PDS gene. (PubMed id 10700480)^{1, 3, 4} Reardon W.... Phelps P.D. (2000)
PDS is a new susceptibility gene to autoimmune thyroid diseases: association and linkage study. (PubMed id 12727986)^{1, 3, 6} Hadj Kacem H....Ayadi H. (2003)
Mutations in the PDS gene in german families with Pendred's syndrome: V138F is a founder mutation. (PubMed id 12788906)^{1, 3, 4} Borck G.... Pohlenz J. (2003)
Mutations of the PDS gene, encoding pendrin, are associated with protein mislocalization and loss of iodide efflux: implications for thyroid dysfunction in Pendred syndrome. (PubMed id 11932316)^{1, 3, 4} Taylor J.P.... Trembath R.C. (2002)
Pendred syndrome: phenotypic variability in two families carrying the same PDS missense mutation. (PubMed id 10602116)^{1, 3, 4} Masmoudi S.... Ayadi M. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5172	HGNC: 8818	AceView: SLC26A4	Ensembl:ENSG00000091137	euGenes: HUgn5172
ECgene: SLC26A4	H-InvDB: SLC26A4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Hereditary hearing loss homepage	http://webhost.ua.ac.be/hhh/
GeneReviews	http://www.genetests.org/query?gene=SLC26A4
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=S&genename=SLC26A4+%40+PDS
Wikipedia	http://en.wikipedia.org/wiki/Pendrin

Licensable Technologies for SLC26A4
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SLC26A4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SLC26A4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SLC26A4		Antibodies for SLC26A4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SLC26A4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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SLC26A4 Gene at Home site.
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SLC26A4 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for SLC26A4

Summaries
for SLC26A4

Genomic Location
for SLC26A4

Proteins
for SLC26A4

Protein Domains/
Families
for SLC26A4

Gene Function
for SLC26A4

Pathways & Interactions
for SLC26A4

Drugs & Compounds
for SLC26A4

Transcripts
for SLC26A4

Expression
for SLC26A4

Orthologs
for SLC26A4

Paralogs
for SLC26A4

SNPs/Variants
for SLC26A4

Disorders & Mutations
for SLC26A4

Medical News
for SLC26A4

Publications
for SLC26A4

Search for SLC26A4

Genome Databases showing SLC26A4

Other Databases showing SLC26A4

Specialized Databases showing SLC26A4

Licensable Technologies
for SLC26A4

Services
for SLC26A4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SLC26A4 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor SLC26A4

Summariesfor SLC26A4

Genomic Locationfor SLC26A4

Proteinsfor SLC26A4

Protein Domains/Familiesfor SLC26A4

Gene Functionfor SLC26A4

Pathways & Interactionsfor SLC26A4

Drugs & Compoundsfor SLC26A4

Transcriptsfor SLC26A4

Expression for SLC26A4

Orthologsfor SLC26A4

Paralogsfor SLC26A4

SNPs/Variantsfor SLC26A4

Disorders & Mutationsfor SLC26A4

Medical Newsfor SLC26A4

Publicationsfor SLC26A4

Search for SLC26A4

Genome Databases showing SLC26A4

Other Databases showing SLC26A4

Specialized Databases showing SLC26A4

Licensable Technologiesfor SLC26A4

Servicesfor SLC26A4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SLC26A4

Summaries
for SLC26A4

Genomic Location
for SLC26A4

Proteins
for SLC26A4

Protein Domains/
Families
for SLC26A4

Gene Function
for SLC26A4

Pathways & Interactions
for SLC26A4

Drugs & Compounds
for SLC26A4

Transcripts
for SLC26A4

Expression
for SLC26A4

Orthologs
for SLC26A4

Paralogs
for SLC26A4

SNPs/Variants
for SLC26A4

Disorders & Mutations
for SLC26A4

Medical News
for SLC26A4

Publications
for SLC26A4

Licensable Technologies
for SLC26A4

Services
for SLC26A4