Aliases for SLC26A3 Gene
External Ids for SLC26A3 Gene
Previous HGNC Symbols for SLC26A3 Gene
Previous GeneCards Identifiers for SLC26A3 Gene
The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008]
GeneCards Summary for SLC26A3 Gene
SLC26A3 (Solute Carrier Family 26 Member 3) is a Protein Coding gene. Diseases associated with SLC26A3 include Diarrhea 1, Secretory Chloride, Congenital and Congenital Chloride Diarrhea. Among its related pathways are Pancreatic secretion and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription cofactor activity. An important paralog of this gene is SLC26A2.
UniProtKB/Swiss-Prot for SLC26A3 Gene
Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.