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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC26A3 Gene

protein-coding GIFtS: 64
GCID: GC07M107405

solute carrier family 26, member 3

(Previous name: congenital chloride diarrhea )
(Previous symbols: DRA, CLD)

Explore 26 diseases affiliated with
SLC26A3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 26, Member 3¹ ²		Down-Regulated In Adenoma Protein²
DRA¹ ² ³ ⁵		Down-Regulated In Adenoma³
CLD¹ ² ⁵		Protein DRA³
Congenital Chloride Diarrhea¹		Solute Carrier Family 26 Member 3³
Chloride Anion Exchanger²

External Ids:	HGNC: 3018¹	Entrez Gene: 1811²	Ensembl: ENSG00000091138⁷	OMIM: 126650⁵	UniProtKB: P40879³

Export aliases for SLC26A3 gene to outside databases

Previous GC identifers: GC07M105889 GC07M106952 GC07M106966 GC07M106951 GC07M106999 GC07M107193 GC07M101768

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC26A3:

The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane

in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the

apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride

absorption, and mutations in this gene have been associated with congenital chloride diarrhea. (provided by RefSeq,

Oct 2008)

UniProtKB/Swiss-Prot: S26A3_HUMAN, P40879

Function: Chloride/bicarbonate exchanger. Mediates the efficient absorbtion of chloride ions in the colon,

participating in fluid homeostasis

Gene Wiki entry for SLC26A3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC26A3 gene promoter:
TBP AML1a p53 Tal-1beta PPAR-alpha FAC1 TFIID SEF-1 (1) ITF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): SLC26A3 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC26A3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC26A3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31 Ensembl cytogenetic band: 7q31.1 HGNC cytogenetic band: 7q31

SLC26A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC26A3 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M107405: view genomic region (about GC identifiers)

Start:	107,405,912 bp from pter	End:	107,443,678 bp from pter
Size:	37,767 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 106,767,027-106,804,797

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S26A3_HUMAN, P40879 (See protein sequence)

Recommended Name: Chloride anion exchanger

Size: 764 amino acids; 84505 Da

Subunit: Interacts with PDZK1

Subcellular location: Apical cell membrane; Multi-pass membrane protein

Developmental stage: Expression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon

Explore the universe of human proteins at neXtProt for SLC26A3: NX_P40879

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

N-glycosylation is required for efficient cell surface expression, and protection from proteolytic degradation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P40879

SLC26A3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000102.1

ENSEMBL proteins:

ENSP00000368375 ENSP00000345873 ENSP00000395955 ENSP00000415817

Reactome Protein details: P40879
Human Recombinant Protein Products for SLC26A3:

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	Uscn Proteins for SLC26A3

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005886	plasma membrane	TAS	--
GO:0016020	membrane	TAS	8896562
GO:0016021	integral to membrane	IEA	--
GO:0016324	apical plasma membrane	IEA	--

SLC26A3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC26A3 for domains About GeneDecksing

4 InterPro domains/families:

IPR002645 STAS_dom

IPR018045 S04_transporter_CS

IPR001902 SulP_transpt

IPR011547 Sulph_transpt

Graphical View of Domain Structure for InterPro Entry P40879

ProtoNet protein and cluster: P40879

1 Blocks protein family: IPB001902 Sulphate transporter

UniProtKB/Swiss-Prot: S26A3_HUMAN, P40879

Similarity: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family

Similarity: Contains 1 STAS domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: S26A3_HUMAN, P40879

Function: Chloride/bicarbonate exchanger. Mediates the efficient absorbtion of chloride ions in the colon,

participating in fluid homeostasis

Genatlas biochemistry entry for SLC26A3:

solute carrier family 26,member A3,sulfate transporter,Na+/sulfate cotransporter DIDs resistant from high endothelial

venules,restrictively expressed,with hyperexpression in placenta,also expressed in transits

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS	7683425
GO:0003712	transcription cofactor activity	TAS	7683425
GO:0005215	transporter activity	TAS	8896562
GO:0008271	secondary active sulfate transmembrane transporter activity	IEA	--
GO:0015301	anion:anion antiporter activity	IEA	--

SLC26A3 for ontologies About GeneDecksing

Phenotypes:
6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slc26a3):

cellular	digestive/alimentary	endocrine/exocrine gland	growth/size	homeostasis/metabolism
mortality/aging

SLC26A3 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Slc26a3^tm1Sole for SLC26A3

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC26A3

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC26A3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

SLC-mediated transmembrane transport

SLC-mediated transmembrane transport

1.00

Transmembrane transport of small molecules

0.50

Multifunctional anion exchangers

Multifunctional anion exchangers

1.00

Mineral absorption

Mineral absorption

1.00

Pancreatic secretion

Pancreatic secretion

1.00

Amino acid and oligopeptide SLC transporters

Transport of inorganic cations/anions and amino acids/oligopeptides

0.52

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for SLC26A3

	Multifunctional anion exchangers
	SLC-mediated transmembrane transport
	Transmembrane transport of small molecules
	Transport of inorganic cations/anions and amino acids/oligopeptides

2 Kegg Pathways (Kegg details for SLC26A3):

	Pancreatic secretion
	Mineral absorption

SLC26A3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SLC26A3

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

4 Interacting proteins for SLC26A3 (P40879^{2, 3} ENSP00000345873⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SLC9A3R2	Q15599²^,³, ENSP00000408005⁴	MINT-1787249 MINT-1787327 MINT-1787222 MINT-1792121 MINT-1787290 I2D: score=2 STRING: ENSP00000408005
SLC9A3R1	O14745³, ENSP00000262613⁴	I2D: score=1 STRING: ENSP00000262613
CFTR	P13569³	I2D: score=1
GEMIN2	ENSP00000308533⁴	STRING: ENSP00000308533

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	TAS	7683425
GO:0006811	ion transport	TAS	--
GO:0006820	anion transport	TAS	9554749
GO:0007588	excretion	TAS	8896562
GO:0008272	sulfate transport	IEA	--

SLC26A3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SLC26A3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC26A3

2 HMDB Compounds for SLC26A3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Chlorine	Cl2 (see all 13)	16887-00-6	--
Hydrogen carbonate	Bicarbonate (see all 19)	71-52-3	--

4 Novoseek chemical compound relationships for SLC26A3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
chloride	73	16	17256057 (1), 16641574 (1), 9843783 (1), 11682697 (1) (see all 10)
sulfate	66.3	13	9473459 (4), 18216024 (1), 9886972 (1), 11231338 (1) (see all 6)
bicarbonate	56	11	11875004 (4), 16641574 (1), 17120762 (1), 12442266 (1) (see all 5)
nacl	37.6	2	19538314 (1), 19056765 (1)

Search CenterWatch for drugs/clinical trials and news about SLC26A3 / S26A3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC26A3 gene:

NM_000111.2

Unigene Cluster for SLC26A3:

Solute carrier family 26, member 3

Hs.1650 [show with all ESTs]

Unigene Representative Sequence: BC025671

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000379083(uc003ves.2) ENST00000340010(uc003ver.2) ENST00000469651

ENST00000468551 ENST00000453332 ENST00000422236

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		hsa-miR-142-5p hsa-miR-187* hsa-miR-494
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Additional cDNA sequence:

AK300651.1 BC025671.1 BX640837.1 L02785.1

5 DOTS entries:

DT.407560 DT.101977360 DT.92019017 DT.100812035 DT.40231188

24/35 AceView cDNA sequences (see all 35):

NM_000111 CD607624 AI339538 BC025671 AU076470 L02785 BP383417 BI766283

BX479055 CD607621 BX089822 AU076819 AW073266 AI880421 BX640837 AI793160

AI951486 AA326909 BG952448 AI805046 BP382952 BX479840 AA631114 AA928419

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A3 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21
SP1:
SP2:					-

ECgene alternative splicing isoforms for SLC26A3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC26A3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATAGGTTTA

About this image

SLC26A3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLC26A3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC26A3

SOURCE GeneReport for Unigene cluster: Hs.1650

SABiosciences Custom PCR Arrays for SLC26A3

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC26A3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SLC26A3 gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLC26A3¹	solute carrier family 26, member 3	66.58(n) 64.32(a)		417700 NM_001199444.1 NP_001186373.1
lizard (Anolis carolinensis)	Reptilia	SLC26A3⁶	--	67(a)	1 ↔ 1	5(97652390-97684502)
African clawed frog (Xenopus laevis)	Amphibia	Xl.24628²	Xenopus laevis transcribed sequence with weak similarity more	76.33(n)		CB206418.1
zebrafish (Danio rerio)	Actinopterygii	si:dkey-31f5.1¹	si:dkey-31f5.1	60.88(n) 59.1(a)		563896 NM_001040175.1 NP_001035265.1
fruit fly (Drosophila melanogaster)	Insecta	Prestin⁶	Prestin	24(a)	possible ortholog	3L(17891989-17900912)
worm (Caenorhabditis elegans)	Secernentea	W04G3.6³	dra like protein	35(a) (best of 6)		X(11115908-11117663) --

ENSEMBL Gene Tree for SLC26A3 (if available)
TreeFam Gene Tree for SLC26A3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC26A3 gene

SLC26A9² SLC26A10² SLC26A7² SLC26A6² SLC26A4² SLC26A1² SLC26A5² SLC26A2²

SLC26A11² SLC26A8²

13 SIMAP similar genes for SLC26A3 using alignment to 5 protein entries: S26A3_HUMAN (see all proteins):

DKFZp686P10213 SLC26A4 SLC26A10 SLC26A11 SLC26A5 SLC26A2

SLC26A6 SLC26A7 SLC26A9 PRES SLC26A8 RESDA1

SLC26A1

SLC26A3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6962400^1,2	C,A	--	106768433(+)	`gagccT/Cgtttc`	1	--	int¹		3		NA CSA	6
rs79659411^1,2		--	106769256(+)	`AATGTC/TGAAAA`	1	--	int¹		0	--	--	--	--
rs75697104^1,2		--	106770405(+)	`GAAGAC/TGGATT`	1	--	int¹		0	--	--	--	--
rs112771057^1,2	F	--	106770876(+)	`AGACAT/CGGACT`	1	--	int¹		3		CSA WA	122
rs78388827^1,2	C	--	106771185(+)	`AATGGG/ATGCTA`	1	--	int¹		2		WA	120
rs10245370^1,2	C	--	106771187(+)	`tgggtG/Actagg`	1	--	int¹		2		CSA WA	120
rs113487054^1,2		--	106771286(+)	`ACTTAG/AAAGTT`	1	--	int¹		1		CSA	2
rs11980165^1,2	H	--	106771728(+)	`tttttC/Tttttt`	1	--	int¹		0	--	--	--	--
rs112046821^1,2	C	--	106772690(+)	`CCTGGTAAC/- TCATT`	1	--	int¹		1		CSA	2
rs77523531^1,2		--	106772832(+)	`AAAAGC/TGTGTA`	1	--	int¹		2		CSA WA	120

HapMap Linkage Disequilibrium report for SLC26A3 (107405912 - 107443678 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SLC26A3
1 CNV: 100071
1 Indel: 41370
Human Gene Mutation Database (HGMD): SLC26A3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC26A3 for disorders           About GeneDecksing

OMIM gene information: 126650
OMIM disorders: 214700
UniProtKB/Swiss-Prot: S26A3_HUMAN, P40879

Defects in SLC26A3 are the cause of diarrhea type 1 (DIAR1) [MIM:214700]; also known as congenital chloride

diarrhea (CLD). DIAR1 is a disease characterized by voluminous watery stools containing an excess of chloride. The

children with this disease are often premature

20/26 diseases for SLC26A3 (see all 26): About MalaCards

chloride diarrhea congenital chloride diarrhea diarrhea chloride diarrhea, congenital, finnish type

adenoma diastrophic dysplasia carpal tunnel syndrome spermatocele

pendred syndrome transverse colon cancer hartnup disease cystic fibrosis

polyhydramnios ulcerative colitis fainting arthropathy

colon cancer amyloidosis fibrosis pharyngitis

4 diseases from the University of Copenhagen DISEASES database for SLC26A3:

Diastrophic dysplasia Diarrhea Polyhydramnios Cystic fibrosis

9 Novoseek disease relationships for SLC26A3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
spermatocele	84.7	1	16421216 (1)
diastrophic dysplasia	83.2	3	17120758 (1), 10857479 (1), 11834742 (1)
pendred syndrome	74	2	17120758 (1), 11834742 (1)
adenoma	71.6	20	11302976 (1), 11496064 (1), 11875004 (1), 9843783 (1) (see all 15)
metabolic alkalosis	67.2	1	19967661 (1)
cystic fibrosis	36.2	5	16421216 (2), 18216024 (1), 19538314 (1), 12651923 (1)
inflammatory bowel diseases	19	1	10857479 (1)
adenocarcinoma	1.39	2	9473459 (1), 10857479 (1)
inflammation	0	2	9843783 (2)

Human Genome Epidemiology (HuGE) Navigator: SLC26A3 (1 document)

Export disorders for SLC26A3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLC26A3 gene, integrated from 9 sources (see all 60):
(articles sorted by number of sources associating them with SLC26A3)

Utopia: connect your pdf to the dynamic
world of online information

Identification of seven novel mutations including the first two genomic rearrangements in SLC26A3 mutated in congenital chloride diarrhea. (PubMed id 11524734)^{1, 2, 9} Hoeglund P....Kere J. (2001)
Role of N-glycosylation in cell surface expression and protection against proteolysis of the intestinal anion exchanger SLC26A3. (PubMed id 22159084)^{1, 2} Hayashi H. and Yamashita Y. (2012)
Update on SLC26A3 mutations in congenital chloride diarrhea. (PubMed id 21394828)^{1, 2} Wedenoja S....Kere J. (2011)
Compound heterozygous mutations in the SLC26A3 gene i n 2 Spanish siblings with congenital chloride diarrhea. (PubMed id 21150650)^{1, 2} RodrA-guez-Herrera A....GutiAcrrez G. (2011)
The CFTR associated protein CAP70 interacts with the apical Cl-/HCO3- exchanger DRA in rabbit small intestinal mucosa. (PubMed id 15766278)^{1, 2} Rossmann H.... Lamprecht G. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger. (PubMed id 11087667)^{1, 3} Lohi H....Kere J. (2000)
Clustering of private mutations in the congenital chloride diarrhea/down-regulated in adenoma gene. (PubMed id 9554749)^{1, 2} Hoeglund P.... Kere J. (1998)
Genetic background of congenital chloride diarrhea in high-incidence populations: Finland, Poland, and Saudi Arabia and Kuwait. (PubMed id 9718329)^{1, 2} Hoglund P....Kere J. (1998)
Mutations of the Down-regulated in adenoma (DRA) gene cause congenital chloride diarrhoea. (PubMed id 8896562)^{1, 2} Hoeglund P.... Kere J. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1811	HGNC: 3018	AceView: SLC26A3	Ensembl:ENSG00000091138	euGenes: HUgn1811
ECgene: SLC26A3	Kegg: 1811	H-InvDB: SLC26A3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLC26A3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SLC26A3	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SLC26A3

Intellectual Property for SLC26A3 gene
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Patent Information for SLC26A3 gene:
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SLC26A3 Gene

solute carrier family 26, member 3

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SLC26A3 Gene

solute carrier family 26, member 3

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