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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC26A3 Gene

protein-coding   GIFtS: 64
GCID: GC07M107405

solute carrier family 26, member 3

(Previous name: congenital chloride diarrhea )
(Previous symbols: DRA, CLD)
 Explore 26 diseases affiliated with
SLC26A3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC26A3    

Aliases
for SLC26A3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 26, Member 31 2     Down-Regulated In Adenoma Protein2
DRA1 2 3 5     Down-Regulated In Adenoma3
CLD1 2 5     Protein DRA3
Congenital Chloride Diarrhea1     Solute Carrier Family 26 Member 33
Chloride Anion Exchanger2     

External Ids:    HGNC: 30181   Entrez Gene: 18112   Ensembl: ENSG000000911387   OMIM: 1266505   UniProtKB: P408793   

Export aliases for SLC26A3 gene to outside databases

Previous GC identifers: GC07M105889 GC07M106952 GC07M106966 GC07M106951 GC07M106999 GC07M107193 GC07M101768


Summaries
for SLC26A3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC26A3:
The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane
in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the
apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride
absorption, and mutations in this gene have been associated with congenital chloride diarrhea. (provided by RefSeq,
Oct 2008)

UniProtKB/Swiss-Prot: S26A3_HUMAN, P40879
Function: Chloride/bicarbonate exchanger. Mediates the efficient absorbtion of chloride ions in the colon,
participating in fluid homeostasis

Gene Wiki entry for SLC26A3


Genomic Views
for SLC26A3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC26A3 gene promoter:
         TBP   AML1a   p53   Tal-1beta   PPAR-alpha   FAC1   TFIID   SEF-1 (1)   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): SLC26A3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC26A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC26A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31   Ensembl cytogenetic band:  7q31.1   HGNC cytogenetic band: 7q31

SLC26A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC26A3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M107405:  view genomic region     (about GC identifiers)

Start:
 107,405,912 bp from pter      End:
 107,443,678 bp from pter
Size:
 37,767 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 106,767,027-106,804,797     

Proteins
for SLC26A3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: S26A3_HUMAN, P40879 (See protein sequence)
Recommended Name: Chloride anion exchanger  
Size: 764 amino acids; 84505 Da
Subunit: Interacts with PDZK1
Subcellular location: Apical cell membrane; Multi-pass membrane protein
Developmental stage: Expression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon

Explore the universe of human proteins at neXtProt for SLC26A3: NX_P40879

Post-translational modifications:

  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • N-glycosylation is required for efficient cell surface expression, and protection from proteolytic degradation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P40879

    • SLC26A3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000102.1  
    ENSEMBL proteins: 
     ENSP00000368375   ENSP00000345873   ENSP00000395955   ENSP00000415817  
    Reactome Protein details: P40879
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    Novus Biologicals SLC26A3 Proteins
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    Uscn Proteins for SLC26A3

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005886plasma membrane TAS--
    GO:0016020membrane TAS8896562
    GO:0016021integral to membrane IEA--
    GO:0016324apical plasma membrane IEA--


    SLC26A3 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SLC26A3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC26A3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR002645 STAS_dom
     IPR018045 S04_transporter_CS
     IPR001902 SulP_transpt
     IPR011547 Sulph_transpt

    Graphical View of Domain Structure for InterPro Entry P40879

    ProtoNet protein and cluster: P40879

    1 Blocks protein family: IPB001902 Sulphate transporter

    UniProtKB/Swiss-Prot: S26A3_HUMAN, P40879
    Similarity: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family
    Similarity: Contains 1 STAS domain


    Function
    for SLC26A3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: S26A3_HUMAN, P40879
    Function: Chloride/bicarbonate exchanger. Mediates the efficient absorbtion of chloride ions in the colon,
    participating in fluid homeostasis

         Genatlas biochemistry entry for SLC26A3:
    solute carrier family 26,member A3,sulfate transporter,Na+/sulfate cotransporter DIDs resistant from high endothelial
    venules,restrictively expressed,with hyperexpression in placenta,also expressed in transits

    miRNA
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    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS7683425
    GO:0003712transcription cofactor activity TAS7683425
    GO:0005215transporter activity TAS8896562
    GO:0008271secondary active sulfate transmembrane transporter activity IEA--
    GO:0015301anion:anion antiporter activity IEA--


    SLC26A3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Slc26a3tm1Sole for SLC26A3
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slc26a3):
     cellular  digestive/alimentary  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     mortality/aging 

    SLC26A3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLC26A3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transmembrane transport of small molecules0.50
    2Multifunctional anion exchangers
    		Multifunctional anion exchangers1.00
    3Mineral absorption
    		Mineral absorption1.00
    4Pancreatic secretion
    		Pancreatic secretion1.00
    5Amino acid and oligopeptide SLC transporters
    		Transport of inorganic cations/anions and amino acids/oligopeptides0.52

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for SLC26A3
        Multifunctional anion exchangers
    SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of inorganic cations/anions and amino acids/oligopeptides


    2         Kegg Pathways  (Kegg details for SLC26A3):
        Pancreatic secretion
    Mineral absorption


    SLC26A3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC26A3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for SLC26A3 (P408792, 3 ENSP000003458734) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC9A3R2Q155992, 3, ENSP000004080054MINT-1787249 MINT-1787327 MINT-1787222 MINT-1792121 MINT-1787290 I2D: score=2 STRING: ENSP00000408005
    SLC9A3R1O147453, ENSP000002626134I2D: score=1 STRING: ENSP00000262613
    CFTRP135693I2D: score=1 
    GEMIN2ENSP000003085334STRING: ENSP00000308533
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent TAS7683425
    GO:0006811ion transport TAS--
    GO:0006820anion transport TAS9554749
    GO:0007588excretion TAS8896562
    GO:0008272sulfate transport IEA--


    SLC26A3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC26A3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC26A3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SLC26A3

    2 HMDB Compounds for SLC26A3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    Hydrogen carbonateBicarbonate (see all 19)71-52-3--
    4 Novoseek chemical compound relationships for SLC26A3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chloride 73 16 17256057 (1), 16641574 (1), 9843783 (1), 11682697 (1) (see all 10)
    sulfate 66.3 13 9473459 (4), 18216024 (1), 9886972 (1), 11231338 (1) (see all 6)
    bicarbonate 56 11 11875004 (4), 16641574 (1), 17120762 (1), 12442266 (1) (see all 5)
    nacl 37.6 2 19538314 (1), 19056765 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC26A3 / S26A3 

    Transcripts
    for SLC26A3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC26A3 gene: 
    NM_000111.2  

    Unigene Cluster for SLC26A3:

    Solute carrier family 26, member 3
    Hs.1650  [show with all ESTs]
    Unigene Representative Sequence: BC025671
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379083(uc003ves.2) ENST00000340010(uc003ver.2) ENST00000469651
    ENST00000468551 ENST00000453332 ENST00000422236

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    hsa-miR-142-5p hsa-miR-187* hsa-miR-494
    SwitchGear 3'UTR luciferase reporter plasmid: SLC26A3 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK300651.1 BC025671.1 BX640837.1 L02785.1 

    5 DOTS entries:

    DT.407560  DT.101977360  DT.92019017  DT.100812035  DT.40231188 

    24/35 AceView cDNA sequences (see all 35):

    NM_000111 CD607624 AI339538 BC025671 AU076470 L02785 BP383417 BI766283 
    BX479055 CD607621 BX089822 AU076819 AW073266 AI880421 BX640837 AI793160 
    AI951486 AA326909 BG952448 AI805046 BP382952 BX479840 AA631114 AA928419 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:                                                                                                                                                
    SP2:              -                                                                                                                                 


    ECgene alternative splicing isoforms for SLC26A3

    Expression
    for SLC26A3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC26A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CATAGGTTTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC26A3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC26A3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC26A3

    SOURCE GeneReport for Unigene cluster: Hs.1650
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    In Situ
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    Orthologs
    for SLC26A3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SLC26A3 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLC26A31 solute carrier family 26, member 3 66.58(n)
    64.32(a)    		   417700  NM_001199444.1  NP_001186373.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC26A36
    		 --
    		 67(a)
    		 1 ↔ 1
    		 5(97652390-97684502)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.246282 Xenopus laevis transcribed sequence with weak similarity more 76.33(n)    CB206418.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii si:dkey-31f5.11 si:dkey-31f5.1 60.88(n)
    59.1(a)    		   563896  NM_001040175.1  NP_001035265.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Prestin6
    		 Prestin
    		 24(a)
    		 possible ortholog
    		 3L(17891989-17900912)
    worm
    (Caenorhabditis elegans)    		 Secernentea W04G3.63 dra like protein 35(a)
    (best of 6)    		   X(11115908-11117663)   --


    ENSEMBL Gene Tree for SLC26A3 (if available)
    TreeFam Gene Tree for SLC26A3 (if available) 

    Paralogs
    for SLC26A3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC26A3 gene
    SLC26A92  SLC26A102  SLC26A72  SLC26A62  SLC26A42  SLC26A12  SLC26A52  SLC26A22  
    SLC26A112  SLC26A82  
    13 SIMAP similar genes for SLC26A3 using alignment to 5 protein entries:     S26A3_HUMAN (see all proteins):
    DKFZp686P10213    SLC26A4    SLC26A10    SLC26A11    SLC26A5    SLC26A2
    SLC26A6    SLC26A7    SLC26A9    PRES    SLC26A8    RESDA1
    SLC26A1

    SLC26A3 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC26A3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/779 NCBI SNPs in SLC26A3 are shown (see all 779)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs69624001,2
    		C,A,--106768433(+) gagccT/Cgtttc 1 -- int13Minor allele frequency- C:0.17NA CSA 6
    rs796594111,2
    		--106769256(+) AATGTC/TGAAAA 1 -- int10--------
    rs756971041,2
    		--106770405(+) GAAGAC/TGGATT 1 -- int10--------
    rs1127710571,2
    		F,--106770876(+) AGACAT/CGGACT 1 -- int13Minor allele frequency- C:0.16CSA WA 122
    rs783888271,2
    		C,--106771185(+) AATGGG/ATGCTA 1 -- int12Minor allele frequency- A:0.08WA 120
    rs102453701,2
    		C,--106771187(+) tgggtG/Actagg 1 -- int12Minor allele frequency- A:0.07CSA WA 120
    rs1134870541,2
    		--106771286(+) ACTTAG/AAAGTT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs119801651,2
    		H--106771728(+) tttttC/Tttttt 1 -- int10--------
    rs1120468211,2
    		C,--106772690(+) CCTGGTAAC/-  
                TCATT     		1 -- int11Minor allele frequency- -:0.50CSA 2
    rs775235311,2
    		--106772832(+) AAAAGC/TGTGTA 1 -- int12Minor allele frequency- T:0.07CSA WA 120

    HapMap Linkage Disequilibrium report for SLC26A3 (107405912 - 107443678 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SLC26A3
         1 CNV: 100071
         1 Indel: 41370
    Human Gene Mutation Database (HGMD): SLC26A3

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for SLC26A3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC26A3 for disorders           About GeneDecksing

    OMIM gene information: 126650   
    OMIM disorders: 214700  
    UniProtKB/Swiss-Prot: S26A3_HUMAN, P40879
  • Defects in SLC26A3 are the cause of diarrhea type 1 (DIAR1) [MIM:214700]; also known as congenital chloride
    • diarrhea (CLD). DIAR1 is a disease characterized by voluminous watery stools containing an excess of chloride. The
    children with this disease are often premature

    20/26 diseases for SLC26A3 (see all 26):    About MalaCards
    chloride diarrhea    congenital chloride diarrhea    diarrhea    chloride diarrhea, congenital, finnish type
    adenoma    diastrophic dysplasia    carpal tunnel syndrome    spermatocele
    pendred syndrome    transverse colon cancer    hartnup disease    cystic fibrosis
    polyhydramnios    ulcerative colitis    fainting    arthropathy
    colon cancer    amyloidosis    fibrosis    pharyngitis

    4 diseases from the University of Copenhagen DISEASES database for SLC26A3:
    Diastrophic dysplasia     Diarrhea     Polyhydramnios     Cystic fibrosis

    9 Novoseek disease relationships for SLC26A3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    spermatocele 84.7 1 16421216 (1)
    diastrophic dysplasia 83.2 3 17120758 (1), 10857479 (1), 11834742 (1)
    pendred syndrome 74 2 17120758 (1), 11834742 (1)
    adenoma 71.6 20 11302976 (1), 11496064 (1), 11875004 (1), 9843783 (1) (see all 15)
    metabolic alkalosis 67.2 1 19967661 (1)
    cystic fibrosis 36.2 5 16421216 (2), 18216024 (1), 19538314 (1), 12651923 (1)
    inflammatory bowel diseases 19 1 10857479 (1)
    adenocarcinoma 1.39 2 9473459 (1), 10857479 (1)
    inflammation 0 2 9843783 (2)

    Human Genome Epidemiology (HuGE) Navigator: SLC26A3 (1 document)

    Export disorders for SLC26A3 gene to outside databases

    Publications
    for SLC26A3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC26A3 gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with SLC26A3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of seven novel mutations including the first two genomic rearrangements in SLC26A3 mutated in congenital chloride diarrhea. (PubMed id 11524734)1, 2, 9 Hoeglund P....Kere J. (2001)
    2. Role of N-glycosylation in cell surface expression and protection against proteolysis of the intestinal anion exchanger SLC26A3. (PubMed id 22159084)1, 2 Hayashi H. and Yamashita Y. (2012)
    3. Update on SLC26A3 mutations in congenital chloride diarrhea. (PubMed id 21394828)1, 2 Wedenoja S....Kere J. (2011)
    4. Compound heterozygous mutations in the SLC26A3 gene i n 2 Spanish siblings with congenital chloride diarrhea. (PubMed id 21150650)1, 2 RodrA-guez-Herrera A....GutiAcrrez G. (2011)
    5. The CFTR associated protein CAP70 interacts with the apical Cl-/HCO3- exchanger DRA in rabbit small intestinal mucosa. (PubMed id 15766278)1, 2 Rossmann H.... Lamprecht G. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger. (PubMed id 11087667)1, 3 Lohi H....Kere J. (2000)
    8. Clustering of private mutations in the congenital chloride diarrhea/down-regulated in adenoma gene. (PubMed id 9554749)1, 2 Hoeglund P.... Kere J. (1998)
    9. Genetic background of congenital chloride diarrhea in high-incidence populations: Finland, Poland, and Saudi Arabia and Kuwait. (PubMed id 9718329)1, 2 Hoglund P....Kere J. (1998)
    10. Mutations of the Down-regulated in adenoma (DRA) gene cause congenital chloride diarrhoea. (PubMed id 8896562)1, 2 Hoeglund P.... Kere J. (1996)

    External Searches for SLC26A3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing SLC26A3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1811 HGNC: 3018 AceView: SLC26A3 Ensembl:ENSG00000091138 euGenes: HUgn1811
    ECgene: SLC26A3 Kegg: 1811 H-InvDB: SLC26A3

    Other Databases showing SLC26A3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC26A3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC26A3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLC26A3 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SLC26A3

    Intellectual Property
    for SLC26A3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC26A3 gene:
    Search GeneIP for patents involving SLC26A3

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