Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC26A11 Gene

Aliases for SLC26A11 Gene

  • Solute Carrier Family 26 Member 11 2 3 4 5
  • Solute Carrier Family 26 (Anion Exchanger), Member 11 2
  • Solute Carrier Family 26, Member 11 2

External Ids for SLC26A11 Gene

Previous GeneCards Identifiers for SLC26A11 Gene

  • GC17U990215
  • GC17P078757
  • GC17P078894
  • GC17P075808
  • GC17P078194
  • GC17P073635

Summaries for SLC26A11 Gene

Entrez Gene Summary for SLC26A11 Gene

  • This gene encodes a member of the solute linked carrier 26 family of anion exchangers. Members of this family of proteins are essential for numerous cellular functions including homeostasis and intracellular electrolyte balance. The encoded protein is a sodium independent sulfate transporter that is sensitive to the anion exchanger inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

GeneCards Summary for SLC26A11 Gene

SLC26A11 (Solute Carrier Family 26 Member 11) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include secondary active sulfate transmembrane transporter activity and sulfate transmembrane transporter activity. An important paralog of this gene is SLC26A1.

UniProtKB/Swiss-Prot for SLC26A11 Gene

  • Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC26A11 Gene

Genomics for SLC26A11 Gene

Regulatory Elements for SLC26A11 Gene

Enhancers for SLC26A11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F080218 1 ENCODE 21.2 +0.8 843 4.5 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A GLI4 ZNF48 ZNF2 ZNF121 LOC105371920 SLC26A11 CARD14 SGSH
GH17F080252 1.9 FANTOM5 Ensembl ENCODE 5.5 +40.0 40001 14.2 CREB3L1 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 TBX21 MEF2D SSRP1 EIF4A3 CHMP6 LOC105371918 LOC105371920 CARD14 LOC100294362 RNF213 RPL12P37 SLC26A11 RBFOX3
GH17F081056 1.3 Ensembl ENCODE 4.6 +838.0 838041 2.8 HDGF PKNOX1 SIN3A GLIS2 ELK1 GATA2 KLF13 ZNF263 MEF2D SMARCA4 RAC3 SLC26A11 BAIAP2 GC17M081121
GH17F080453 1.5 FANTOM5 ENCODE 1.2 +236.1 236095 5.0 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 NPTX1 EIF4A3 TEPSIN SGSH GAA SLC26A11 ENSG00000260369 ENSG00000279273
GH17F080212 1.1 Ensembl 0.4 -6.5 -6527 1.3 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 SGSH CARD14 EIF4A3 GC17M080212 SLC26A11
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC26A11 on UCSC Golden Path with GeneCards custom track

Promoters for SLC26A11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001354864 801 2201 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A ZNF48 ZNF2 ZNF121 GLIS2

Transcription factor binding sites by QIAGEN in the SLC26A11 gene promoter:

Genomic Location for SLC26A11 Gene

Chromosome:
17
Start:
80,219,699 bp from pter
End:
80,253,509 bp from pter
Size:
33,811 bases
Orientation:
Plus strand

Genomic View for SLC26A11 Gene

Genes around SLC26A11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC26A11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC26A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC26A11 Gene

Proteins for SLC26A11 Gene

  • Protein details for SLC26A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WA9-S2611_HUMAN
    Recommended name:
    Sodium-independent sulfate anion transporter
    Protein Accession:
    Q86WA9
    Secondary Accessions:
    • B2RCI7
    • Q86VX1
    • Q86YX7
    • Q8IV11
    • Q8N2I1
    • Q8NG03

    Protein attributes for SLC26A11 Gene

    Size:
    606 amino acids
    Molecular mass:
    65299 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC26A11 Gene

Post-translational modifications for SLC26A11 Gene

  • Ubiquitination at Lys 578 and Lys 600
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC26A11 Gene

Domains & Families for SLC26A11 Gene

Gene Families for SLC26A11 Gene

Protein Domains for SLC26A11 Gene

Suggested Antigen Peptide Sequences for SLC26A11 Gene

Graphical View of Domain Structure for InterPro Entry

Q86WA9

UniProtKB/Swiss-Prot:

S2611_HUMAN :
  • Contains 1 STAS domain.
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Domain:
  • Contains 1 STAS domain.
Family:
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
genes like me logo Genes that share domains with SLC26A11: view

Function for SLC26A11 Gene

Molecular function for SLC26A11 Gene

UniProtKB/Swiss-Prot Function:
Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC).

Gene Ontology (GO) - Molecular Function for SLC26A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005254 chloride channel activity IBA --
GO:0008271 secondary active sulfate transmembrane transporter activity IEA --
GO:0008509 anion transmembrane transporter activity IDA 12626430
GO:0015106 bicarbonate transmembrane transporter activity IBA --
GO:0015116 sulfate transmembrane transporter activity IEA,IBA --
genes like me logo Genes that share ontologies with SLC26A11: view
genes like me logo Genes that share phenotypes with SLC26A11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC26A11

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC26A11 Gene

Localization for SLC26A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC26A11 Gene

Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC26A11 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
lysosome 5
golgi apparatus 5
nucleus 4

Gene Ontology (GO) - Cellular Components for SLC26A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA,IDA 20957757
GO:0005783 endoplasmic reticulum IDA 12626430
GO:0005794 Golgi apparatus IDA 12626430
genes like me logo Genes that share ontologies with SLC26A11: view

Pathways & Interactions for SLC26A11 Gene

genes like me logo Genes that share pathways with SLC26A11: view

Interacting Proteins for SLC26A11 Gene

Gene Ontology (GO) - Biological Process for SLC26A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0008272 sulfate transport IEA,IDA 12626430
GO:0015701 bicarbonate transport IBA --
GO:0019532 oxalate transport IEA --
genes like me logo Genes that share ontologies with SLC26A11: view

No data available for SIGNOR curated interactions for SLC26A11 Gene

Drugs & Compounds for SLC26A11 Gene

(2) Additional Compounds for SLC26A11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
Sulfate
  • Sulfate (ion 2-)
  • Sulfate anion
  • Sulfate anion(2-)
  • Sulfate dianion
  • Sulfate ion
14808-79-8
genes like me logo Genes that share compounds with SLC26A11: view

Transcripts for SLC26A11 Gene

Unigene Clusters for SLC26A11 Gene

Solute carrier family 26, member 11:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A11 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5:
SP6: - - - - -
SP7: - - - -
SP8:
SP9: -

ExUns: 16 ^ 17 ^ 18 ^ 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for SLC26A11 Gene

GeneLoc Exon Structure for
SLC26A11
ECgene alternative splicing isoforms for
SLC26A11

Expression for SLC26A11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC26A11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC26A11 Gene

This gene is overexpressed in Retina (37.9) and Fetal Liver (31.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC26A11 Gene



Protein tissue co-expression partners for SLC26A11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC26A11 Gene:

SLC26A11

SOURCE GeneReport for Unigene cluster for SLC26A11 Gene:

Hs.4866

mRNA Expression by UniProt/SwissProt for SLC26A11 Gene:

Q86WA9-S2611_HUMAN
Tissue specificity: Detected in all tissues tested with highest expression observed in brain, kidney, HEVEC and placenta and lowest in pancreas, skeletal muscle, liver, lung and heart.
genes like me logo Genes that share expression patterns with SLC26A11: view

Primer Products

No data available for mRNA differential expression in normal tissues for SLC26A11 Gene

Orthologs for SLC26A11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC26A11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC26A11 34 35
  • 99.35 (n)
dog
(Canis familiaris)
Mammalia SLC26A11 34 35
  • 86.91 (n)
cow
(Bos Taurus)
Mammalia SLC26A11 34 35
  • 84.63 (n)
mouse
(Mus musculus)
Mammalia Slc26a11 34 16 35
  • 82.8 (n)
rat
(Rattus norvegicus)
Mammalia Slc26a11 34
  • 81.29 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC26A11 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC26A11 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC26A11 34 35
  • 72.26 (n)
lizard
(Anolis carolinensis)
Reptilia SLC26A11 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc26a11 34
  • 61.26 (n)
zebrafish
(Danio rerio)
Actinopterygii slc26a11 34 35
  • 62.56 (n)
wufd14d06 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012302 34
  • 52.19 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5002 35
  • 40 (a)
OneToMany
CG7912 35
  • 40 (a)
OneToMany
CG6928 35
  • 36 (a)
OneToMany
CG9717 35
  • 35 (a)
OneToMany
Esp 35
  • 34 (a)
OneToMany
CG5404 35
  • 32 (a)
OneToMany
CG9702 35
  • 32 (a)
OneToMany
CG6125 35
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sulp-1 35
  • 14 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR077C 34
  • 47.93 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUL1 34 35 37
  • 44.18 (n)
SUL2 35
  • 21 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F19338g 34
  • 43.36 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04433 34
  • 50.77 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC869.05c 34
  • 46.05 (n)
Species where no ortholog for SLC26A11 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC26A11 Gene

ENSEMBL:
Gene Tree for SLC26A11 (if available)
TreeFam:
Gene Tree for SLC26A11 (if available)

Paralogs for SLC26A11 Gene

genes like me logo Genes that share paralogs with SLC26A11: view

Variants for SLC26A11 Gene

Sequence variations from dbSNP and Humsavar for SLC26A11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs786200990 Uncertain significance 80,220,230(-) CTGCT(-/GCT)CCTCG nc-transcript-variant, upstream-variant-2KB, cds-indel
rs10577282 -- 80,224,202(+) GTGTG(-/AG)TGTGT intron-variant
rs10664169 -- 80,224,295(+) AGTGA(-/GTGCGTGTGTGAGTGAGT)GTGCG intron-variant
rs10664170 -- 80,224,370(+) gtgtg(A/C/T)gtgcg intron-variant
rs10871502 -- 80,231,345(+) tttta(A/G)tggag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC26A11 Gene

Variant ID Type Subtype PubMed ID
nsv833562 CNV loss 17160897
nsv828123 CNV gain 20364138
nsv576131 CNV loss 21841781
nsv469591 CNV loss 16826518
nsv457968 CNV loss 19166990
nsv1066606 CNV gain 25217958
esv3554852 CNV deletion 23714750

Variation tolerance for SLC26A11 Gene

Residual Variation Intolerance Score: 98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.60; 72.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC26A11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC26A11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC26A11 Gene

Disorders for SLC26A11 Gene

Relevant External Links for SLC26A11

Genetic Association Database (GAD)
SLC26A11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC26A11

No disorders were found for SLC26A11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC26A11 Gene

Publications for SLC26A11 Gene

  1. The proteome of lysosomes. (PMID: 20957757) Schroeder B.A. … Saftig P. (Proteomics 2010) 3 4 64
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Molecular and functional characterization of SLC26A11, a sodium- independent sulfate transporter from high endothelial venules. (PMID: 12626430) Vincourt J.-B. … Girard J.-P. (FASEB J. 2003) 3 4 64
  5. N-glycosylation and topology of the human SLC26 family of anion transport membrane proteins. (PMID: 24647542) Li J. … Reithmeier R.A. (Am. J. Physiol., Cell Physiol. 2014) 3 64

Products for SLC26A11 Gene

Sources for SLC26A11 Gene

Content
Loading form....