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Aliases for SLC26A11 Gene

Aliases for SLC26A11 Gene

  • Solute Carrier Family 26 Member 11 2 3 4
  • Solute Carrier Family 26 (Anion Exchanger), Member 11 2 5
  • Solute Carrier Family 26, Member 11 2

External Ids for SLC26A11 Gene

Previous GeneCards Identifiers for SLC26A11 Gene

  • GC17U990215
  • GC17P078757
  • GC17P078894
  • GC17P075808
  • GC17P078194
  • GC17P073635

Summaries for SLC26A11 Gene

Entrez Gene Summary for SLC26A11 Gene

  • This gene encodes a member of the solute linked carrier 26 family of anion exchangers. Members of this family of proteins are essential for numerous cellular functions including homeostasis and intracellular electrolyte balance. The encoded protein is a sodium independent sulfate transporter that is sensitive to the anion exchanger inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

GeneCards Summary for SLC26A11 Gene

SLC26A11 (Solute Carrier Family 26 Member 11) is a Protein Coding gene. GO annotations related to this gene include secondary active sulfate transmembrane transporter activity and sulfate transmembrane transporter activity. An important paralog of this gene is SLC26A2.

UniProtKB/Swiss-Prot for SLC26A11 Gene

  • Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC26A11 Gene

Genomics for SLC26A11 Gene

Regulatory Elements for SLC26A11 Gene

Promoters for SLC26A11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC26A11 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SLC26A11 gene promoter:

Genomic Location for SLC26A11 Gene

Chromosome:
17
Start:
80,219,699 bp from pter
End:
80,253,509 bp from pter
Size:
33,811 bases
Orientation:
Plus strand

Genomic View for SLC26A11 Gene

Genes around SLC26A11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC26A11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC26A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC26A11 Gene

Proteins for SLC26A11 Gene

  • Protein details for SLC26A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WA9-S2611_HUMAN
    Recommended name:
    Sodium-independent sulfate anion transporter
    Protein Accession:
    Q86WA9
    Secondary Accessions:
    • B2RCI7
    • Q86VX1
    • Q86YX7
    • Q8IV11
    • Q8N2I1
    • Q8NG03

    Protein attributes for SLC26A11 Gene

    Size:
    606 amino acids
    Molecular mass:
    65299 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC26A11 Gene

Proteomics data for SLC26A11 Gene at MOPED

Post-translational modifications for SLC26A11 Gene

  • Ubiquitination at Lys 578 and Lys 600
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC26A11 Gene

Domains & Families for SLC26A11 Gene

Gene Families for SLC26A11 Gene

Protein Domains for SLC26A11 Gene

Suggested Antigen Peptide Sequences for SLC26A11 Gene

Graphical View of Domain Structure for InterPro Entry

Q86WA9

UniProtKB/Swiss-Prot:

S2611_HUMAN :
  • Contains 1 STAS domain.
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Domain:
  • Contains 1 STAS domain.
Family:
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
genes like me logo Genes that share domains with SLC26A11: view

Function for SLC26A11 Gene

Molecular function for SLC26A11 Gene

UniProtKB/Swiss-Prot Function:
Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC).

Gene Ontology (GO) - Molecular Function for SLC26A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019531 oxalate transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC26A11: view
genes like me logo Genes that share phenotypes with SLC26A11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC26A11

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC26A11 Gene

Localization for SLC26A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC26A11 Gene

Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC26A11 Gene COMPARTMENTS Subcellular localization image for SLC26A11 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
golgi apparatus 5
lysosome 5
plasma membrane 5
vacuole 5
nucleus 4

Gene Ontology (GO) - Cellular Components for SLC26A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 20957757
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SLC26A11: view

Pathways & Interactions for SLC26A11 Gene

SuperPathways for SLC26A11 Gene

No Data Available

Interacting Proteins for SLC26A11 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000355384%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000007516%0d%0a9606.ENSP00000355651%0d%0a9606.ENSP00000349560%0d%0a9606.ENSP00000350378%0d%0a
Selected Interacting proteins: Q86WA9-S2611_HUMAN ENSP00000355384 for SLC26A11 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for SLC26A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019532 oxalate transport IBA --
GO:1902476 chloride transmembrane transport IBA --
genes like me logo Genes that share ontologies with SLC26A11: view

No data available for Pathways by source and SIGNOR curated interactions for SLC26A11 Gene

Drugs & Compounds for SLC26A11 Gene

(2) Additional Compounds for SLC26A11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
Sulfate
  • Sulfate (ion 2-)
  • Sulfate anion
  • Sulfate anion(2-)
  • Sulfate dianion
  • Sulfate ion
14808-79-8
genes like me logo Genes that share compounds with SLC26A11: view

Transcripts for SLC26A11 Gene

Unigene Clusters for SLC26A11 Gene

Solute carrier family 26, member 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A11 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5:
SP6: - - - - -
SP7: - - - -
SP8:
SP9: -

ExUns: 16 ^ 17 ^ 18 ^ 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for SLC26A11 Gene

GeneLoc Exon Structure for
SLC26A11
ECgene alternative splicing isoforms for
SLC26A11

Expression for SLC26A11 Gene

mRNA expression in normal human tissues for SLC26A11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC26A11 Gene

This gene is overexpressed in Retina (37.9) and Fetal Liver (31.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC26A11 Gene



SOURCE GeneReport for Unigene cluster for SLC26A11 Gene Hs.4866

mRNA Expression by UniProt/SwissProt for SLC26A11 Gene

Q86WA9-S2611_HUMAN
Tissue specificity: Detected in all tissues tested with highest expression observed in brain, kidney, HEVEC and placenta and lowest in pancreas, skeletal muscle, liver, lung and heart.
genes like me logo Genes that share expression patterns with SLC26A11: view

Protein tissue co-expression partners for SLC26A11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SLC26A11 Gene

Orthologs for SLC26A11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC26A11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC26A11 35
  • 99.35 (n)
  • 99.14 (a)
SLC26A11 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC26A11 35
  • 84.63 (n)
  • 83.73 (a)
SLC26A11 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC26A11 36
  • 87 (a)
OneToOne
SLC26A11 35
  • 86.91 (n)
  • 89.44 (a)
mouse
(Mus musculus)
Mammalia Slc26a11 16
Slc26a11 36
  • 82 (a)
OneToOne
Slc26a11 35
  • 82.8 (n)
  • 82.85 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC26A11 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC26A11 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc26a11 35
  • 81.29 (n)
  • 81.06 (a)
chicken
(Gallus gallus)
Aves SLC26A11 35
  • 72.26 (n)
  • 68.25 (a)
SLC26A11 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC26A11 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc26a11 35
  • 61.26 (n)
  • 61.83 (a)
zebrafish
(Danio rerio)
Actinopterygii slc26a11 36
  • 61 (a)
OneToOne
slc26a11 35
  • 62.56 (n)
  • 62.14 (a)
wufd14d06 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012302 35
  • 52.19 (n)
  • 42.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5002 36
  • 40 (a)
OneToMany
CG5404 36
  • 32 (a)
OneToMany
CG6125 36
  • 31 (a)
OneToMany
CG6928 36
  • 36 (a)
OneToMany
CG7912 36
  • 40 (a)
OneToMany
CG9702 36
  • 32 (a)
OneToMany
CG9717 36
  • 35 (a)
OneToMany
Esp 36
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sulp-1 36
  • 14 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR077C 35
  • 47.93 (n)
  • 38.17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUL1 35
  • 44.18 (n)
  • 38.21 (a)
SUL1 36
  • 21 (a)
ManyToMany
SUL2 36
  • 21 (a)
ManyToMany
SUL1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F19338g 35
  • 43.36 (n)
  • 35.32 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04433 35
  • 50.77 (n)
  • 41.38 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC869.05c 35
  • 46.05 (n)
  • 37.44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for SLC26A11:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC26A11 Gene

ENSEMBL:
Gene Tree for SLC26A11 (if available)
TreeFam:
Gene Tree for SLC26A11 (if available)

Paralogs for SLC26A11 Gene

genes like me logo Genes that share paralogs with SLC26A11: view

Variants for SLC26A11 Gene

Sequence variations from dbSNP and Humsavar for SLC26A11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_068239 -
rs3935689 -- 80,223,661(-) CCCAG(G/T)GCAGG intron-variant
rs7219513 -- 80,232,700(+) ggtct(C/G)tttga intron-variant
rs7209632 -- 80,226,114(+) CACAG(G/T)TTTAA intron-variant
rs4889842 -- 80,235,054(+) tgtgt(A/C/T)ggctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC26A11 Gene

Variant ID Type Subtype PubMed ID
nsv469591 CNV Loss 16826518
nsv833562 CNV Loss 17160897
dgv3297n71 CNV Loss 21882294
dgv3298n71 CNV Loss 21882294
nsv457968 CNV Loss 19166990
nsv908982 CNV Loss 21882294
nsv828123 CNV Gain 20364138
nsv908983 CNV Gain 21882294
nsv908984 CNV Gain 21882294

Variation tolerance for SLC26A11 Gene

Residual Variation Intolerance Score: 98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.60; 72.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC26A11 Gene

HapMap Linkage Disequilibrium report
SLC26A11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC26A11 Gene

Disorders for SLC26A11 Gene

Relevant External Links for SLC26A11

Genetic Association Database (GAD)
SLC26A11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC26A11

No disorders were found for SLC26A11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC26A11 Gene

Publications for SLC26A11 Gene

  1. The proteome of lysosomes. (PMID: 20957757) Schroeder B.A. … Saftig P. (Proteomics 2010) 3 4 67
  2. N-glycosylation and topology of the human SLC26 family of anion transport membrane proteins. (PMID: 24647542) Li J. … Reithmeier R.A. (Am. J. Physiol., Cell Physiol. 2014) 3
  3. Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. (PMID: 21752829) Palmieri M. … Ballabio A. (Hum. Mol. Genet. 2011) 3
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3
  5. Renal physiology of SLC26 anion exchangers. (PMID: 17693766) SindiA8 A. … Romero M.F. (Curr. Opin. Nephrol. Hypertens. 2007) 3

Products for SLC26A11 Gene

Sources for SLC26A11 Gene

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