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Aliases for SLC26A11 Gene

Aliases for SLC26A11 Gene

  • Solute Carrier Family 26 (Anion Exchanger), Member 11 2 3
  • Solute Carrier Family 26, Member 11 2
  • Solute Carrier Family 26 Member 11 4

External Ids for SLC26A11 Gene

Previous GeneCards Identifiers for SLC26A11 Gene

  • GC17U990215
  • GC17P078757
  • GC17P078894
  • GC17P075808
  • GC17P078194
  • GC17P073635

Summaries for SLC26A11 Gene

Entrez Gene Summary for SLC26A11 Gene

  • This gene encodes a member of the solute linked carrier 26 family of anion exchangers. Members of this family of proteins are essential for numerous cellular functions including homeostasis and intracellular electrolyte balance. The encoded protein is a sodium independent sulfate transporter that is sensitive to the anion exchanger inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

GeneCards Summary for SLC26A11 Gene

SLC26A11 (Solute Carrier Family 26 (Anion Exchanger), Member 11) is a Protein Coding gene. GO annotations related to this gene include secondary active sulfate transmembrane transporter activity and anion transmembrane transporter activity. An important paralog of this gene is SLC26A2.

UniProtKB/Swiss-Prot for SLC26A11 Gene

  • Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC26A11 Gene

Genomics for SLC26A11 Gene

Regulatory Elements for SLC26A11 Gene

Transcription factor binding sites by QIAGEN in the SLC26A11 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC26A11 Gene

Start:
80,219,699 bp from pter
End:
80,253,509 bp from pter
Size:
33,811 bases
Orientation:
Plus strand

Genomic View for SLC26A11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC26A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC26A11 Gene

Proteins for SLC26A11 Gene

  • Protein details for SLC26A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WA9-S2611_HUMAN
    Recommended name:
    Sodium-independent sulfate anion transporter
    Protein Accession:
    Q86WA9
    Secondary Accessions:
    • B2RCI7
    • Q86VX1
    • Q86YX7
    • Q8IV11
    • Q8N2I1
    • Q8NG03

    Protein attributes for SLC26A11 Gene

    Size:
    606 amino acids
    Molecular mass:
    65299 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC26A11 Gene

Proteomics data for SLC26A11 Gene at MOPED

Post-translational modifications for SLC26A11 Gene

  • Ubiquitination at Lys578 and Lys600
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC26A11 Gene

Domains for SLC26A11 Gene

Gene Families for SLC26A11 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC26A11 Gene

Suggested Antigen Peptide Sequences for SLC26A11 Gene

Graphical View of Domain Structure for InterPro Entry

Q86WA9

UniProtKB/Swiss-Prot:

S2611_HUMAN :
  • Q86WA9
Domain:
  • Contains 1 STAS domain.
Family:
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
genes like me logo Genes that share domains with SLC26A11: view

Function for SLC26A11 Gene

Molecular function for SLC26A11 Gene

UniProtKB/Swiss-Prot Function: Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC).

Gene Ontology (GO) - Molecular Function for SLC26A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008271 secondary active sulfate transmembrane transporter activity IEA --
GO:0008509 anion transmembrane transporter activity IDA 12626430
GO:0015116 sulfate transmembrane transporter activity --
GO:0015301 anion:anion antiporter activity IEA --
genes like me logo Genes that share ontologies with SLC26A11: view

Phenotypes for SLC26A11 Gene

GenomeRNAi human phenotypes for SLC26A11:
genes like me logo Genes that share phenotypes with SLC26A11: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC26A11 Gene

Localization for SLC26A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC26A11 Gene

Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC26A11 Gene COMPARTMENTS Subcellular localization image for SLC26A11 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
lysosome 5
plasma membrane 5
vacuole 5

Gene Ontology (GO) - Cellular Components for SLC26A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 20957757
GO:0005783 endoplasmic reticulum IDA 12626430
GO:0005794 Golgi apparatus IDA 12626430
GO:0005886 plasma membrane IDA 12626430
GO:0016021 integral component of membrane IDA 12626430
genes like me logo Genes that share ontologies with SLC26A11: view

Pathways for SLC26A11 Gene

SuperPathways for SLC26A11 Gene

No Data Available

Interacting Proteins for SLC26A11 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000355384%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000007516%0d%0a9606.ENSP00000349560%0d%0a9606.ENSP00000355651%0d%0a9606.ENSP00000350378%0d%0a
Selected Interacting proteins: ENSP00000355384 Q86WA9-S2611_HUMAN for SLC26A11 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLC26A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008272 sulfate transport IDA 12626430
GO:0098656 anion transmembrane transport IDA 12626430
GO:1902358 sulfate transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC26A11: view

No data available for Pathways by source for SLC26A11 Gene

Compounds for SLC26A11 Gene

(2) HMDB Compounds for SLC26A11 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5
Sulfate
  • Sulfate (ion 2-)
14808-79-8
genes like me logo Genes that share compounds with SLC26A11: view

Transcripts for SLC26A11 Gene

Unigene Clusters for SLC26A11 Gene

Solute carrier family 26, member 11:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC26A11

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A11 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5:
SP6: - - - - -
SP7: - - - -
SP8:
SP9: -

ExUns: 16 ^ 17 ^ 18 ^ 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for SLC26A11 Gene

GeneLoc Exon Structure for
SLC26A11
ECgene alternative splicing isoforms for
SLC26A11

Expression for SLC26A11 Gene

mRNA expression in normal human tissues for SLC26A11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC26A11 Gene

SOURCE GeneReport for Unigene cluster for SLC26A11 Gene Hs.4866

mRNA Expression by UniProt/SwissProt for SLC26A11 Gene

Q86WA9-S2611_HUMAN
Tissue specificity: Detected in all tissues tested with highest expression observed in brain, kidney, HEVEC and placenta and lowest in pancreas, skeletal muscle, liver, lung and heart.
genes like me logo Genes that share expressions with SLC26A11: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SLC26A11 Gene

Orthologs for SLC26A11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC26A11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC26A11 35
  • 99.35 (n)
  • 99.14 (a)
SLC26A11 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC26A11 35
  • 84.63 (n)
  • 83.73 (a)
SLC26A11 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC26A11 35
  • 86.91 (n)
  • 89.44 (a)
SLC26A11 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc26a11 35
  • 82.8 (n)
  • 82.85 (a)
Slc26a11 16
Slc26a11 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC26A11 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC26A11 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc26a11 35
  • 81.29 (n)
  • 81.06 (a)
chicken
(Gallus gallus)
Aves SLC26A11 35
  • 72.26 (n)
  • 68.25 (a)
SLC26A11 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC26A11 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc26a11 35
  • 61.26 (n)
  • 61.83 (a)
zebrafish
(Danio rerio)
Actinopterygii slc26a11 35
  • 62.56 (n)
  • 62.14 (a)
slc26a11 36
  • 61 (a)
OneToOne
wufd14d06 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012302 35
  • 52.19 (n)
  • 42.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5002 36
  • 40 (a)
OneToMany
CG5404 36
  • 32 (a)
OneToMany
CG6125 36
  • 31 (a)
OneToMany
CG6928 36
  • 36 (a)
OneToMany
CG7912 36
  • 40 (a)
OneToMany
CG9702 36
  • 32 (a)
OneToMany
CG9717 36
  • 35 (a)
OneToMany
Esp 36
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sulp-1 36
  • 14 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR077C 35
  • 47.93 (n)
  • 38.17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUL1 35
  • 44.18 (n)
  • 38.21 (a)
SUL1 36
  • 21 (a)
ManyToMany
SUL1 38
SUL2 36
  • 21 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F19338g 35
  • 43.36 (n)
  • 35.32 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04433 35
  • 50.77 (n)
  • 41.38 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC869.05c 35
  • 46.05 (n)
  • 37.44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for SLC26A11:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC26A11 Gene

ENSEMBL:
Gene Tree for SLC26A11 (if available)
TreeFam:
Gene Tree for SLC26A11 (if available)

Paralogs for SLC26A11 Gene

genes like me logo Genes that share paralogs with SLC26A11: view

Variants for SLC26A11 Gene

Sequence variations from dbSNP and Humsavar for SLC26A11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs3924207 -- 80,236,977(-) ACCTC(A/G)AAGGA reference, synonymous-codon, nc-transcript-variant
rs3935689 -- 80,223,661(-) CCCAG(G/T)GCAGG intron-variant
rs4075237 -- 80,228,163(-) agagc(A/G)aaact intron-variant
rs4075238 -- 80,228,071(-) tgctc(A/G)agtga intron-variant
rs4889842 -- 80,235,054(+) tgtgt(A/C/T)ggctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC26A11 Gene

Variant ID Type Subtype PubMed ID
nsv469591 CNV Loss 16826518
nsv833562 CNV Loss 17160897
dgv3297n71 CNV Loss 21882294
dgv3298n71 CNV Loss 21882294
nsv457968 CNV Loss 19166990
nsv908982 CNV Loss 21882294
nsv828123 CNV Gain 20364138
nsv908983 CNV Gain 21882294
nsv908984 CNV Gain 21882294

Relevant External Links for SLC26A11 Gene

HapMap Linkage Disequilibrium report
SLC26A11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC26A11 Gene

Disorders for SLC26A11 Gene

(1) University of Copenhagen DISEASES for SLC26A11 Gene

Relevant External Links for SLC26A11

Genetic Association Database (GAD)
SLC26A11
genes like me logo Genes that share disorders with SLC26A11: view

No data available for UniProtKB/Swiss-Prot for SLC26A11 Gene

Publications for SLC26A11 Gene

  1. The proteome of lysosomes. (PMID: 20957757) Schroeder B.A. … Saftig P. (Proteomics 2010) 3 4
  2. Molecular and functional characterization of SLC26A11, a sodium- independent sulfate transporter from high endothelial venules. (PMID: 12626430) Vincourt J.-B. … Girard J.-P. (FASEB J. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for SLC26A11 Gene

Sources for SLC26A11 Gene

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