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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC26A10 Gene

protein-coding   GIFtS: 47
GCID: GC12P058013

solute carrier family 26, member 10

 Explore 9 diseases affiliated with
SLC26A10 via our new
 Human Malady Compendium 
Biological research products
for SLC26A10
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Solute Carrier Family 26, Member 101 2
Solute Carrier Family 26 Member 102

External Ids:    HGNC: 144701   Entrez Gene: 650122   Ensembl: ENSG000001355027   UniProtKB: Q8NG043   

Export aliases for SLC26A10 gene to outside databases

Previous GC identifers: GC12P057605 GC12P058147 GC12P057721 GC12P056290 GC12P056301 GC12P055051


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: S2610_HUMAN, Q8NG04
Function: Chloride/bicarbonate exchanger (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC26A10 gene promoter:
         AhR   Tal-1   AP-4   Tal-1beta   Arnt   E47   GATA-2   Pax-3   ITF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC26A10 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC26A10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC26A10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13

SLC26A10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC26A10 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P058013:  view genomic region     (about GC identifiers)

Start:
58,013,310 bp from pter      End:
58,019,934 bp from pter
Size:
6,625 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S2610_HUMAN, Q8NG04 (See protein sequence)
Recommended Name: Solute carrier family 26 member 10  
Size: 563 amino acids; 60059 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Caution: According to PubMed:12759755, it is a transcribed pseudogene. They however do not provide experimental
evidences to support this affirmation
Sequence caution: Sequence=BAC85515.1; Type=Erroneous initiation;
Secondary accessions: A6NMJ2 B6ZDQ3 Q6ZWI7
Alternative splicing: 2 isoforms:  Q8NG04-1   Q8NG04-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC26A10: NX_Q8NG04

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NG04

  • SLC26A10 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins: NP_597996.2  
    ENSEMBL proteins: 
     ENSP00000431994   ENSP00000320217   ENSP00000403619   ENSP00000368520  

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    Uscn Proteins for SLC26A10

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    SLC26A10 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SLC26A10 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002645 STAS_dom
     IPR011547 Sulph_transpt

    Graphical View of Domain Structure for InterPro Entry Q8NG04

    ProtoNet protein and cluster: Q8NG04

    1 Blocks protein family: IPB000005 Helix-turn-helix

    UniProtKB/Swiss-Prot: S2610_HUMAN, Q8NG04
    Similarity: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family
    Similarity: Contains 1 STAS domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: S2610_HUMAN, Q8NG04
    Function: Chloride/bicarbonate exchanger (By similarity)

    miRNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015116sulfate transmembrane transporter activity IEA--
    GO:0015297antiporter activity IEA--


    SLC26A10 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC26A10

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008272sulfate transport IEA--


    SLC26A10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC26A10

    2 HMDB Compounds for SLC26A10    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    Hydrogen carbonateBicarbonate (see all 19)71-52-3--
    Search CenterWatch for drugs/clinical trials and news about SLC26A10 / S2610 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC26A10 gene (2 alternative transcripts): 
    NM_001018084.1  NM_133489.2  

    Unigene Cluster for SLC26A10:

    Solute carrier family 26, member 10
    Hs.727726  [show with all ESTs]
    Unigene Representative Sequence: NM_133489
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000474359 ENST00000320442 ENST00000440686 ENST00000497297 ENST00000463802
    ENST00000487816(uc009zpz.2) ENST00000474791 ENST00000490243 ENST00000483647
    ENST00000379218(uc001spe.3 uc001spf.3)

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidSLC26A10 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC26A10 (see all 4)
    OriGene shRNA RFP: SLC26A10
    OriGene siRNA: SLC26A10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC26A10
    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC26A10 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: SLC26A10 (NM_133489)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC26A10
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    Additional cDNA sequence: 

    AF331523.1 AK314085.1 

    6 DOTS entries:

    DT.86854056  DT.101978805  DT.309821  DT.75157488  DT.121109079  DT.40130790 

    24/122 AceView cDNA sequences (see all 122):

    AA031486 BX451871 BX112080 AW264299 BM783700 AW161485 AI018809 AI654427 
    BM750262 BM783082 BM740405 AA463846 CR599416 AA325176 AK057416 AI677902 
    BM783529 AF331523 AW136644 BM748075 BM783729 BX452641 BM759898 CR624415 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A10 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^
    SP1:                          -                                         -                                                                                       
    SP2:                                -                                   -                                                                                       
    SP3:                                                                                                                                                            
    SP4:                                -                                                                                                                           
    SP5:                                                                                                                                                            

    ExUns: 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33
    SP1:                                                                                                                  
    SP2:                                                                                                                  
    SP3:                                                                    -                                   -         
    SP4:                                                                                                                  
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for SLC26A10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC26A10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCCTTGAAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    SLC26A10 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierAdult Endothelial CellsBlood Brain Barrier, Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    Genevestigator expression for SLC26A10

    SOURCE GeneReport for Unigene cluster: Hs.727726
        SABiosciences Custom PCR Arrays for SLC26A10
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC26A10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLC26A10 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia SLC26A106
    --
    63(a)
    1 ↔ 1
    GL343212.1(128-19420)
    zebrafish
    (Danio rerio)
    Actinopterygii slc26a106
    solute carrier family 26, member 10
    41(a)
    1 ↔ 1
    23(28320845-28334001)
    fruit fly
    (Drosophila melanogaster)
    Insecta Prestin6
    Prestin
    23(a)
    possible ortholog
    3L(17891989-17900912)
    worm
    (Caenorhabditis elegans)
    Secernentea sulp-76
    sulp-86
    (see all 8)
    SULfate Permease family member (sulp-8)
    (see all 8)
    27(a)
    26(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    X(11080612-11087408)
    V(9670008-9673547)


    ENSEMBL Gene Tree for SLC26A10 (if available)
    TreeFam Gene Tree for SLC26A10 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC26A10 gene
    SLC26A92  SLC26A32  SLC26A72  SLC26A62  SLC26A42  SLC26A12  SLC26A52  SLC26A22  
    SLC26A112  SLC26A82  
    11 SIMAP similar genes for SLC26A10 using alignment to 3 protein entries:     S2610_HUMAN (see all proteins):
    SLC26A2    SLC26A6    SLC26A4    RESDA1    SLC26A3    SLC26A7
    DKFZp686P10213    SLC26A5    SLC26A1    SLC26A9    PRES

    SLC26A10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/163 NCBI SNPs in SLC26A10 are shown (see all 163    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1125080971,2
    --58011717(+) CAAGAA/GCGGAC 1 -- us2k10--------
    rs1842990461,2
    --58011799(+) CAGCCA/GTGTCC 1 -- us2k10--------
    rs1889804121,2
    --58011856(+) CCATTC/TGTCCC 1 -- us2k10--------
    rs9030671,2
    C,F,A,H,--58011857(+) CATTCA/GTCCCT 1 -- us2k123Minor allele frequency- G:0.36NS EA NA WA CSA 2354
    rs758963981,2
    F,--58011859(+) TTCGTC/GCCTTG 1 -- us2k12Minor allele frequency- G:0.08WA EA 238
    rs733479081,2
    C,--58011875(+) AGTCAC/TGTGCA 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1128166961,2
    --58012012(+) TGTAGC/TGCCCA 1 -- us2k10--------
    rs1163701761,2
    F,--58012013(+) GTAGCG/ACCCAG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs21699871,2
    C,F,A,H,--58012111(+) CTGGGG/AGACCA 1 -- us2k16Minor allele frequency- A:0.45NA WA EA 364
    rs1161423011,2
    F,--58012139(+) GTGCCG/AAAGAT 1 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for SLC26A10 (58013310 - 58019934 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLC26A10: --
    Human Gene Mutation Database (HGMD): SLC26A10

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC26A10
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC26A10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SLC26A10 for disorders           About GeneDecksing

    9 diseases for SLC26A10:    About MalaCards
    primary hyperoxaluria    nephrolithiasis    fainting    pharyngitis
    tuberculosis    pancreatitis    malaria    neuronitis
    mycobacterium tuberculosis

    1 disease from the University of Copenhagen DISEASES database for SLC26A10:
    Primary hyperoxaluria

    Export disorders for SLC26A10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC26A10 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SLC26A10)
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    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    3. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
    4. The SLC26 gene family of multifunctional anion exchangers. (PubMed id 12759755)2 Mount D.B. and Romero M.F. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger. (PubMed id 11087667)2 Lohi H....Kere J. (2000)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 65012 HGNC: 14470 AceView: GEFTandSLC26A10 Ensembl:ENSG00000135502 euGenes: HUgn65012
    ECgene: SLC26A10 H-InvDB: SLC26A10

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC26A10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC26A10 gene:
    Search GeneIP for patents involving SLC26A10

    GeneCards and IP:
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