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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC26A10 Gene

protein-coding   GIFtS: 48
GCID: GC12P058013

Solute Carrier Family 26, Member 10

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 26, Member 101 2
Solute Carrier Family 26 Member 102

External Ids:    HGNC: 144701   Entrez Gene: 650122   Ensembl: ENSG000001355027   UniProtKB: Q8NG043   

Export aliases for SLC26A10 gene to outside databases

Previous GC identifers: GC12P057605 GC12P058147 GC12P057721 GC12P056290 GC12P056301 GC12P055051


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC26A10 Gene: 
SLC26A10 (solute carrier family 26, member 10) is a protein-coding gene. Diseases associated with SLC26A10 include fainting, and primary hyperoxaluria. GO annotations related to this gene include antiporter activity and sulfate transmembrane transporter activity. An important paralog of this gene is SLC26A9.

UniProtKB/Swiss-Prot: S2610_HUMAN, Q8NG04
Function: Chloride/bicarbonate exchanger (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC26A10 gene promoter:
         AhR   Tal-1   AP-4   Tal-1beta   Arnt   E47   GATA-2   Pax-3   ITF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC26A10 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC26A10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC26A10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13

SLC26A10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC26A10 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P058013:  view genomic region     (about GC identifiers)

Start:
58,013,310 bp from pter      End:
58,019,934 bp from pter
Size:
6,625 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S2610_HUMAN, Q8NG04 (See protein sequence)
Recommended Name: Solute carrier family 26 member 10  
Size: 563 amino acids; 60059 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Caution: According to PubMed:12759755, it is a transcribed pseudogene. They however do not provide experimental
evidences to support this affirmation
Sequence caution: Sequence=BAC85515.1; Type=Erroneous initiation;
Secondary accessions: A6NMJ2 B6ZDQ3 Q6ZWI7
Alternative splicing: 2 isoforms:  Q8NG04-1   Q8NG04-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC26A10: NX_Q8NG04

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NG04

  • SLC26A10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_597996.2  
    ENSEMBL proteins: 
     ENSP00000431994   ENSP00000320217   ENSP00000403619   ENSP00000368520  

    Human Recombinant Protein Products for SLC26A10: 
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    Cloud-Clone Corp. Proteins for SLC26A10 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    SLC26A10 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: SLC26A10 
    Other SLC26 anion exchangers

    2 InterPro protein domains:
     IPR002645 STAS_dom
     IPR011547 Sulph_transpt

    Graphical View of Domain Structure for InterPro Entry Q8NG04

    ProtoNet protein and cluster: Q8NG04

    1 Blocks protein domain: IPB000005 Helix-turn-helix

    UniProtKB/Swiss-Prot: S2610_HUMAN, Q8NG04
    Similarity: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family
    Similarity: Contains 1 STAS domain


    SLC26A10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S2610_HUMAN, Q8NG04
    Function: Chloride/bicarbonate exchanger (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015116sulfate transmembrane transporter activity IEA--
    GO:0015297antiporter activity IEA--
         
    SLC26A10 for ontologies           About GeneDecksing


    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC26A10 
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC26A10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC26A10

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008272sulfate transport IEA--

    SLC26A10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC26A10 (S2610)

    2 HMDB Compounds for SLC26A10    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    Hydrogen carbonateBicarbonate (see all 19)71-52-3--

    Search CenterWatch for drugs/clinical trials and news about SLC26A10 / S2610

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC26A10 gene (2 alternative transcripts): 
    NM_001018084.1  NM_133489.2  

    Unigene Cluster for SLC26A10:

    Solute carrier family 26, member 10
    Hs.727726  [show with all ESTs]
    Unigene Representative Sequence: NM_133489
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000474359 ENST00000320442 ENST00000440686 ENST00000497297 ENST00000463802
    ENST00000487816(uc009zpz.2) ENST00000474791 ENST00000490243 ENST00000483647
    ENST00000379218(uc001spe.3 uc001spf.3)
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC26A10

    Additional mRNA sequence: 

    AF331523.1 AK314085.1 

    8 DOTS entries:

    DT.423176  DT.309821  DT.86854056  DT.101978805  DT.102841116  DT.40130790  DT.75157488  DT.121109079 

    24/122 AceView cDNA sequences (see all 122):

    AI089627 AA325176 AI018809 AW136644 BX097050 BM783095 CR624415 BM783729 
    BM783529 AK057416 BM740405 BM759898 AA463846 AA031486 AF331523 BM748075 
    CD722079 AI677902 AL536956 BX452641 BM783700 CR599416 BM783082 BM750262 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A10 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^
    SP1:                          -                                         -                                                                                       
    SP2:                                -                                   -                                                                                       
    SP3:                                                                                                                                                            
    SP4:                                -                                                                                                                           
    SP5:                                                                                                                                                            

    ExUns: 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33
    SP1:                                                                                                                  
    SP2:                                                                                                                  
    SP3:                                                                    -                                   -         
    SP4:                                                                                                                  
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for SLC26A10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC26A10 expression in normal human tissues (normalized intensities)      SLC26A10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCCTTGAAC
    SLC26A10 Expression
    About this image


    SLC26A10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
             cerebellum   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             mouse/organ system/cardiovascular system   
     
     Blood Brain Barrier (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Blood (Cardiovascular System)
             mouse/organ system/cardiovascular system   

    Genevestigator expression for SLC26A10

    SOURCE GeneReport for Unigene cluster: Hs.727726
        SABiosciences Custom PCR Arrays for SLC26A10
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC26A10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC26A10 gene from 6/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc26a105 solute carrier family 26, member 10   --   10 (74.50 cM) 127172426 
    lizard
    (Anolis carolinensis)
    Reptilia SLC26A106
    Uncharacterized protein
    53(a)
    1 ↔ 1
    GL343212.1(4031-19420)
    zebrafish
    (Danio rerio)
    Actinopterygii slc26a106
    solute carrier family 26, member 10
    41(a)
    1 ↔ 1
    23(28320845-28334001)
    fruit fly
    (Drosophila melanogaster)
    Insecta Prestin6
    Prestin
    22(a)
    1 → many
    3L(17891989-17900912)
    worm
    (Caenorhabditis elegans)
    Secernentea sulp-86
    sulp-76
    (see all 8)
    Protein SULP-7, isoform d
    (see all 8)
    26(a)
    26(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    V(9670032-9673571)
    X(11080678-11087474)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SUL16
    SUL26
    High affinity sulfate permease of the SulP anion t...
    High affinity sulfate permease; sulfate uptake is ...
    12(a)
    11(a)
    many ↔ many
    many ↔ many
    II(789235-791814)
    XII(323544-326225)


    ENSEMBL Gene Tree for SLC26A10 (if available)
    TreeFam Gene Tree for SLC26A10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC26A10 gene
    SLC26A92  SLC26A32  SLC26A62  SLC26A12  SLC26A52  SLC26A112  SLC26A22  SLC26A72  
    SLC26A42  SLC26A82  
    11 SIMAP similar genes for SLC26A10 using alignment to 3 protein entries:     S2610_HUMAN (see all proteins):
    SLC26A2    SLC26A6    SLC26A4    RESDA1    SLC26A3    SLC26A7
    PRES    DKFZp686P10213    SLC26A5    SLC26A1    SLC26A9

    SLC26A10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/224 SNPs in SLC26A10 are shown (see all 224)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0456784
    A colorectal cancer sample4--see VAR_0456782 L S mis40--------
    VAR_0456014
    ----see VAR_0456012 L V mis40--------
    rs1125080971,2
    C--58011717(+) CAAGAA/GCGGAC 1 -- us2k10--------
    rs1842990461,2
    --58011799(+) CAGCCA/GTGTCC 1 -- us2k10--------
    rs1889804121,2
    --58011856(+) CCATTC/TGTCCC 1 -- us2k10--------
    rs9030671,2
    C,F,A,H--58011857(+) CATTCA/GTCCCT 1 -- us2k123Minor allele frequency- G:0.36NS EA NA WA CSA 2354
    rs758963981,2
    F--58011859(+) TTCGTC/GCCTTG 1 -- us2k12Minor allele frequency- G:0.08WA EA 238
    rs733479081,2
    C,F--58011875(+) AGTCAC/TGTGCA 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1119874671,2
    C--58012007(+) CAGGAC/TGTAGC 1 -- us2k10--------
    rs1128166961,2
    C--58012012(+) TGTAGC/TGCCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC26A10 (58013310 - 58019934 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SLC26A10: --

    Human Gene Mutation Database (HGMD): SLC26A10
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC26A10
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    5 diseases for SLC26A10:    About MalaCards
    fainting    primary hyperoxaluria    nephrolithiasis    tuberculosis
    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for SLC26A10:
    Primary hyperoxaluria

    SLC26A10 for disorders           About GeneDecksing


    Export disorders for SLC26A10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC26A10 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SLC26A10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    3. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
    4. The SLC26 gene family of multifunctional anion exchangers. (PubMed id 12759755)2 Mount D.B. and Romero M.F. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger. (PubMed id 11087667)2 Lohi H....Kere J. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 65012 HGNC: 14470 AceView: GEFTandSLC26A10 Ensembl:ENSG00000135502 euGenes: HUgn65012
    ECgene: SLC26A10 H-InvDB: SLC26A10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC26A10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC26A10 gene:
    Search GeneIP for patents involving SLC26A10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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