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Aliases for SLC26A10 Gene

Aliases for SLC26A10 Gene

  • Solute Carrier Family 26, Member 10 2 3

External Ids for SLC26A10 Gene

Previous GeneCards Identifiers for SLC26A10 Gene

  • GC12P057605
  • GC12P058147
  • GC12P057721
  • GC12P056290
  • GC12P056301
  • GC12P058013
  • GC12P055051

Summaries for SLC26A10 Gene

GeneCards Summary for SLC26A10 Gene

SLC26A10 (Solute Carrier Family 26, Member 10) is a Protein Coding gene. GO annotations related to this gene include antiporter activity and sulfate transmembrane transporter activity. An important paralog of this gene is SLC26A2.

UniProtKB/Swiss-Prot for SLC26A10 Gene

  • Chloride/bicarbonate exchanger.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC26A10 Gene

Genomics for SLC26A10 Gene

Regulatory Elements for SLC26A10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC26A10 Gene

Chromosome:
12
Start:
57,619,527 bp from pter
End:
57,626,151 bp from pter
Size:
6,625 bases
Orientation:
Plus strand

Genomic View for SLC26A10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC26A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC26A10 Gene

Proteins for SLC26A10 Gene

  • Protein details for SLC26A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG04-S2610_HUMAN
    Recommended name:
    Solute carrier family 26 member 10
    Protein Accession:
    Q8NG04
    Secondary Accessions:
    • A6NMJ2
    • B6ZDQ3
    • Q6ZWI7

    Protein attributes for SLC26A10 Gene

    Size:
    563 amino acids
    Molecular mass:
    60059 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85515.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC26A10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC26A10 Gene

Proteomics data for SLC26A10 Gene at MOPED

Post-translational modifications for SLC26A10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC26A10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC26A10 Gene

Domains & Families for SLC26A10 Gene

Gene Families for SLC26A10 Gene

Protein Domains for SLC26A10 Gene

Suggested Antigen Peptide Sequences for SLC26A10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NG04

UniProtKB/Swiss-Prot:

S2610_HUMAN :
  • Contains 1 STAS domain.
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Domain:
  • Contains 1 STAS domain.
Family:
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
genes like me logo Genes that share domains with SLC26A10: view

Function for SLC26A10 Gene

Molecular function for SLC26A10 Gene

UniProtKB/Swiss-Prot Function:
Chloride/bicarbonate exchanger.

Gene Ontology (GO) - Molecular Function for SLC26A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005254 chloride channel activity IBA --
GO:0008271 secondary active sulfate transmembrane transporter activity IEA --
GO:0015106 bicarbonate transmembrane transporter activity IBA --
GO:0015116 sulfate transmembrane transporter activity IBA --
GO:0015297 antiporter activity --
genes like me logo Genes that share ontologies with SLC26A10: view
genes like me logo Genes that share phenotypes with SLC26A10: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC26A10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC26A10 Gene

Localization for SLC26A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC26A10 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SLC26A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC26A10: view

No data available for Subcellular locations from COMPARTMENTS for SLC26A10 Gene

Pathways & Interactions for SLC26A10 Gene

SuperPathways for SLC26A10 Gene

No Data Available

Interacting Proteins for SLC26A10 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000320217%0d%0a9606.ENSP00000007516%0d%0a9606.ENSP00000431822%0d%0a9606.ENSP00000003084%0d%0a
Selected Interacting proteins: ENSP00000320217 for SLC26A10 Gene via STRING

Gene Ontology (GO) - Biological Process for SLC26A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008272 sulfate transport --
GO:0015701 bicarbonate transport IBA --
GO:0019532 oxalate transport IBA --
GO:0042391 regulation of membrane potential IBA --
GO:0051453 regulation of intracellular pH IBA --
genes like me logo Genes that share ontologies with SLC26A10: view

No data available for Pathways by source and SIGNOR curated interactions for SLC26A10 Gene

Drugs & Compounds for SLC26A10 Gene

(2) Additional Compounds for SLC26A10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
Hydrogen carbonate
  • Bicarbonate
  • Bicarbonate (HCO3-)
  • Bicarbonate anion
  • Bicarbonate ion
  • Bicarbonate ion (HCO31-)
71-52-3
genes like me logo Genes that share compounds with SLC26A10: view

Transcripts for SLC26A10 Gene

mRNA/cDNA for SLC26A10 Gene

Unigene Clusters for SLC26A10 Gene

Solute carrier family 26, member 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC26A10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A10 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^
SP1: - -
SP2: - -
SP3:
SP4: -
SP5:
SP6: - - - - - - -
SP7: - - -
SP8: -
SP9:
SP10:
SP11:
SP12:

ExUns: 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33
SP1:
SP2:
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for SLC26A10 Gene

GeneLoc Exon Structure for
SLC26A10
ECgene alternative splicing isoforms for
SLC26A10

Expression for SLC26A10 Gene

mRNA expression in normal human tissues for SLC26A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC26A10 Gene

This gene is overexpressed in Brain - Cerebellum (x5.8) and Brain - Cerebellar Hemisphere (x4.7).

Protein differential expression in normal tissues from HIPED for SLC26A10 Gene

This gene is overexpressed in Heart (42.6) and Ovary (26.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC26A10 Gene



SOURCE GeneReport for Unigene cluster for SLC26A10 Gene Hs.727726

genes like me logo Genes that share expression patterns with SLC26A10: view

Protein tissue co-expression partners for SLC26A10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLC26A10 Gene

Orthologs for SLC26A10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC26A10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC26A10 35
  • 98.4 (n)
  • 96.45 (a)
mouse
(Mus musculus)
Mammalia Slc26a10 16
Slc26a10 36
  • 63 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC26A10 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC26A10 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 24 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia SLC26A10 36
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc26a10 36
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Prestin 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sulp-2 36
  • 23 (a)
ManyToMany
sulp-3 36
  • 19 (a)
ManyToMany
sulp-4 36
  • 23 (a)
ManyToMany
sulp-5 36
  • 23 (a)
ManyToMany
sulp-6 36
  • 18 (a)
ManyToMany
sulp-7 36
  • 26 (a)
ManyToMany
sulp-8 36
  • 26 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUL1 36
  • 12 (a)
ManyToMany
SUL2 36
  • 11 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToMany
Species with no ortholog for SLC26A10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC26A10 Gene

ENSEMBL:
Gene Tree for SLC26A10 (if available)
TreeFam:
Gene Tree for SLC26A10 (if available)

Paralogs for SLC26A10 Gene

(11) SIMAP similar genes for SLC26A10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC26A10: view

Variants for SLC26A10 Gene

Sequence variations from dbSNP and Humsavar for SLC26A10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1871417 -- 57,625,196(-) ACCAT(A/G)CAACA intron-variant
rs7314152 -- 57,623,918(+) GGTAA(C/G/T)GAGCA intron-variant
rs73347916 -- 57,624,487(+) CCTAT(C/T)CCTAT intron-variant
rs73347918 -- 57,625,157(+) TGCAG(G/T)TGAGA splice-donor-variant
rs111352851 -- 57,624,611(+) GGTGG(A/G)CATAG intron-variant

Variation tolerance for SLC26A10 Gene

Residual Variation Intolerance Score: 91.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.31; 90.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC26A10 Gene

HapMap Linkage Disequilibrium report
SLC26A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC26A10 Gene

Disorders for SLC26A10 Gene

Relevant External Links for SLC26A10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC26A10
genes like me logo Genes that share disorders with SLC26A10: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC26A10 Gene

Publications for SLC26A10 Gene

  1. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 67
  2. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 67
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 67
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  5. The SLC26 gene family of multifunctional anion exchangers. (PMID: 12759755) Mount D.B. … Romero M.F. (Pflugers Arch. 2004) 67

Products for SLC26A10 Gene

Sources for SLC26A10 Gene

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