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Aliases for SLC26A10 Gene

Aliases for SLC26A10 Gene

  • Solute Carrier Family 26 Member 10 2 3 5
  • Solute Carrier Family 26, Member 10 2

External Ids for SLC26A10 Gene

Previous GeneCards Identifiers for SLC26A10 Gene

  • GC12P057605
  • GC12P058147
  • GC12P057721
  • GC12P056290
  • GC12P056301
  • GC12P058013
  • GC12P055051

Summaries for SLC26A10 Gene

GeneCards Summary for SLC26A10 Gene

SLC26A10 (Solute Carrier Family 26 Member 10) is a Protein Coding gene. GO annotations related to this gene include antiporter activity and sulfate transmembrane transporter activity. An important paralog of this gene is SLC26A7.

UniProtKB/Swiss-Prot for SLC26A10 Gene

  • Chloride/bicarbonate exchanger.

Additional gene information for SLC26A10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC26A10 Gene

Genomics for SLC26A10 Gene

Regulatory Elements for SLC26A10 Gene

Enhancers for SLC26A10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H057109 1.5 ENCODE dbSUPER 58.8 -508.3 -508274 3 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 MCM3 MEF2D SSRP1 NEMP1 BAZ2A EEF1AKMT3 ENSG00000257740 SMARCC2 CDK4 CTDSP2 PAN2 ANKRD52 DTX3
GH12H057590 1.1 ENCODE 22.3 -28.1 -28106 1 HDGF ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 ZNF207 SP3 MXD4 ENSG00000224713 NEMP1 SLC26A10 LOC283387 TSPAN31 TSFM EEF1AKMT3 ARHGEF25 CDK4 CTDSP2
GH12H057245 1.2 ENCODE dbSUPER 20.3 -374.3 -374295 0 PKNOX1 ZNF2 ATF7 YY2 REST ZNF662 ZNF491 ZNF518A ZNF610 GLIS1 ENSG00000257740 DTX3 NEMP1 PAN2 LOC283387 ANKRD52 ENSG00000224713 NAB2 EEF1AKMT3 ZBTB39
GH12H057454 1.6 Ensembl ENCODE dbSUPER 14.7 -163.8 -163757 3 HDGF PKNOX1 MLX ARNT ARID4B DMAP1 ZNF2 YY1 ZNF766 CBX5 NEMP1 BAZ2A ENSG00000224713 MBD6 SLC26A10 RPL13AP23 LINC02403 RPL21P103 RN7SL809P RNU6-343P
GH12H057457 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.1 -159.0 -159037 5 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 CBX5 ZNF143 NEMP1 BAZ2A ARHGAP9 ZBTB39 ENSG00000224713 ARHGEF25 PRIM1 MBD6 SLC26A10 RN7SL809P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC26A10 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC26A10 Gene

Chromosome:
12
Start:
57,619,527 bp from pter
End:
57,626,151 bp from pter
Size:
6,625 bases
Orientation:
Plus strand

Genomic View for SLC26A10 Gene

Genes around SLC26A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC26A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC26A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC26A10 Gene

Proteins for SLC26A10 Gene

  • Protein details for SLC26A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG04-S2610_HUMAN
    Recommended name:
    Solute carrier family 26 member 10
    Protein Accession:
    Q8NG04
    Secondary Accessions:
    • A6NMJ2
    • B6ZDQ3
    • Q6ZWI7

    Protein attributes for SLC26A10 Gene

    Size:
    563 amino acids
    Molecular mass:
    60059 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85515.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC26A10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC26A10 Gene

Post-translational modifications for SLC26A10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC26A10 Gene

No data available for DME Specific Peptides for SLC26A10 Gene

Domains & Families for SLC26A10 Gene

Gene Families for SLC26A10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC26A10 Gene

Suggested Antigen Peptide Sequences for SLC26A10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NG04

UniProtKB/Swiss-Prot:

S2610_HUMAN :
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Family:
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
genes like me logo Genes that share domains with SLC26A10: view

Function for SLC26A10 Gene

Molecular function for SLC26A10 Gene

UniProtKB/Swiss-Prot Function:
Chloride/bicarbonate exchanger.

Phenotypes From GWAS Catalog for SLC26A10 Gene

Gene Ontology (GO) - Molecular Function for SLC26A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005254 chloride channel activity IBA --
GO:0008271 secondary active sulfate transmembrane transporter activity IEA --
GO:0015106 bicarbonate transmembrane transporter activity IBA --
GO:0015116 sulfate transmembrane transporter activity IBA,IEA --
GO:0015297 antiporter activity IEA --
genes like me logo Genes that share ontologies with SLC26A10: view
genes like me logo Genes that share phenotypes with SLC26A10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC26A10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC26A10 Gene

Localization for SLC26A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC26A10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC26A10 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SLC26A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC26A10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC26A10 Gene

Pathways & Interactions for SLC26A10 Gene

SuperPathways for SLC26A10 Gene

No Data Available

Interacting Proteins for SLC26A10 Gene

Gene Ontology (GO) - Biological Process for SLC26A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008272 sulfate transport IEA --
GO:0015701 bicarbonate transport IBA --
GO:0019532 oxalate transport IEA --
GO:0042391 regulation of membrane potential IBA --
genes like me logo Genes that share ontologies with SLC26A10: view

No data available for Pathways by source and SIGNOR curated interactions for SLC26A10 Gene

Drugs & Compounds for SLC26A10 Gene

(2) Additional Compounds for SLC26A10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
Hydrogen carbonate
  • Bicarbonate
  • Bicarbonate (HCO3-)
  • Bicarbonate anion
  • Bicarbonate ion
  • Bicarbonate ion (HCO31-)
71-52-3
genes like me logo Genes that share compounds with SLC26A10: view

Transcripts for SLC26A10 Gene

Unigene Clusters for SLC26A10 Gene

Solute carrier family 26, member 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC26A10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A10 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^
SP1: - -
SP2: - -
SP3:
SP4: -
SP5:
SP6: - - - - - - -
SP7: - - -
SP8: -
SP9:
SP10:
SP11:
SP12:

ExUns: 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33
SP1:
SP2:
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for SLC26A10 Gene

GeneLoc Exon Structure for
SLC26A10
ECgene alternative splicing isoforms for
SLC26A10

Expression for SLC26A10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC26A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC26A10 Gene

This gene is overexpressed in Brain - Cerebellum (x5.8) and Brain - Cerebellar Hemisphere (x4.7).

Protein differential expression in normal tissues from HIPED for SLC26A10 Gene

This gene is overexpressed in Heart (42.6) and Ovary (26.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC26A10 Gene



Protein tissue co-expression partners for SLC26A10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC26A10 Gene:

SLC26A10

SOURCE GeneReport for Unigene cluster for SLC26A10 Gene:

Hs.727726

Evidence on tissue expression from TISSUES for SLC26A10 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SLC26A10: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC26A10 Gene

Orthologs for SLC26A10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC26A10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC26A10 33
  • 98.4 (n)
dog
(Canis familiaris)
Mammalia SLC26A10 34
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC26A10 34
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc26a10 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 24 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia SLC26A10 34
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc26a10 34
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Prestin 34
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sulp-7 34
  • 26 (a)
ManyToMany
sulp-8 34
  • 26 (a)
ManyToMany
sulp-2 34
  • 23 (a)
ManyToMany
sulp-4 34
  • 23 (a)
ManyToMany
sulp-5 34
  • 23 (a)
ManyToMany
sulp-3 34
  • 19 (a)
ManyToMany
sulp-6 34
  • 18 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUL1 34
  • 12 (a)
ManyToMany
SUL2 34
  • 11 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
OneToMany
Species where no ortholog for SLC26A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC26A10 Gene

ENSEMBL:
Gene Tree for SLC26A10 (if available)
TreeFam:
Gene Tree for SLC26A10 (if available)

Paralogs for SLC26A10 Gene

(11) SIMAP similar genes for SLC26A10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC26A10: view

Variants for SLC26A10 Gene

Sequence variations from dbSNP and Humsavar for SLC26A10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_045678 A colorectal cancer sample
rs1000249907 -- 57,622,016(+) CTCGA(C/T)ACTGT intron-variant, upstream-variant-2KB
rs1000603740 -- 57,620,582(+) ACCCT(G/T)CCAGG intron-variant
rs1001302779 -- 57,624,035(+) AGCAT(A/G)CGCCA nc-transcript-variant, reference, missense, utr-variant-3-prime
rs1001508563 -- 57,618,453(+) ATGAG(C/T)GGGGT nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC26A10 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV gain+loss 15286789

Variation tolerance for SLC26A10 Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.31; 90.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC26A10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC26A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC26A10 Gene

Disorders for SLC26A10 Gene

Relevant External Links for SLC26A10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC26A10

No disorders were found for SLC26A10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC26A10 Gene

Publications for SLC26A10 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L … McKnight A (Retrovirology 2011) 3 60
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4 60
  4. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjöblom T … Velculescu VE (Science (New York, N.Y.) 2006) 4 60
  5. The SLC26 gene family of multifunctional anion exchangers. (PMID: 12759755) Mount DB … Romero MF (Pflugers Archiv : European journal of physiology 2004) 4 60

Products for SLC26A10 Gene

Sources for SLC26A10 Gene

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