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Aliases for SLC26A10 Gene

Aliases for SLC26A10 Gene

  • Solute Carrier Family 26 Member 10 2 3 5
  • Solute Carrier Family 26, Member 10 2

External Ids for SLC26A10 Gene

Previous GeneCards Identifiers for SLC26A10 Gene

  • GC12P057605
  • GC12P058147
  • GC12P057721
  • GC12P056290
  • GC12P056301
  • GC12P058013
  • GC12P055051

Summaries for SLC26A10 Gene

GeneCards Summary for SLC26A10 Gene

SLC26A10 (Solute Carrier Family 26 Member 10) is a Protein Coding gene. GO annotations related to this gene include antiporter activity and sulfate transmembrane transporter activity. An important paralog of this gene is SLC26A7.

UniProtKB/Swiss-Prot for SLC26A10 Gene

  • Chloride/bicarbonate exchanger.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC26A10 Gene

Genomics for SLC26A10 Gene

Regulatory Elements for SLC26A10 Gene

Enhancers for SLC26A10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F057693 1.1 ENCODE 16.6 +74.7 74709 1.8 HDGF PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 YY1 ZNF143 FOS KLF13 SLC26A10 LOC283387 NEMP1 OS9 ENSG00000257342
GH12F057583 0.9 ENCODE 12.2 -36.0 -36035 0.2 HDGF CBX3 TBL1XR1 WRNIP1 ARID4B THRB ZNF2 RAD21 GLIS2 ZNF143 DTX3 ARHGEF25 ENSG00000224713 SLC26A10 GC12P057584 GC12M057556
GH12F057575 0.9 ENCODE 12 -42.9 -42867 1.4 TBP ARID4B ZNF48 RARA SLC30A9 GATA4 CREM THAP11 SP5 MXD4 DTX3 ARHGEF25 ENSG00000224713 SLC26A10 KIF5A DCTN2 B4GALNT1 DDIT3 MBD6 MIR616
GH12F057579 0.8 ENCODE 12 -39.6 -39648 0.8 SOX13 ELF3 DRAP1 TBP MXI1 ATF1 SAP130 ARID4B ZNF384 CEBPG DCTN2 DTX3 ARHGEF25 ENSG00000224713 SLC26A10 KIF5A B4GALNT1 TSPAN31 AGAP2 DDIT3
GH12F057454 1.4 Ensembl ENCODE 4.6 -163.8 -163757 3.5 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B DMAP1 ZNF2 YY1 ZNF143 RNU6-343P NEMP1 LOC283387 ENSG00000224713 RBMS2 BAZ2A RPL13AP23 LOC105369785 RPL21P103 RN7SL809P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC26A10 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC26A10 Gene

57,619,527 bp from pter
57,626,151 bp from pter
6,625 bases
Plus strand

Genomic View for SLC26A10 Gene

Genes around SLC26A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC26A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC26A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC26A10 Gene

Proteins for SLC26A10 Gene

  • Protein details for SLC26A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 26 member 10
    Protein Accession:
    Secondary Accessions:
    • A6NMJ2
    • B6ZDQ3
    • Q6ZWI7

    Protein attributes for SLC26A10 Gene

    563 amino acids
    Molecular mass:
    60059 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC85515.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC26A10 Gene


neXtProt entry for SLC26A10 Gene

Post-translational modifications for SLC26A10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC26A10 Gene

No data available for DME Specific Peptides for SLC26A10 Gene

Domains & Families for SLC26A10 Gene

Gene Families for SLC26A10 Gene

Protein Domains for SLC26A10 Gene

Suggested Antigen Peptide Sequences for SLC26A10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



S2610_HUMAN :
  • Contains 1 STAS domain.
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
  • Contains 1 STAS domain.
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
genes like me logo Genes that share domains with SLC26A10: view

Function for SLC26A10 Gene

Molecular function for SLC26A10 Gene

UniProtKB/Swiss-Prot Function:
Chloride/bicarbonate exchanger.

Gene Ontology (GO) - Molecular Function for SLC26A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005254 chloride channel activity IBA --
GO:0008271 secondary active sulfate transmembrane transporter activity IEA --
GO:0015106 bicarbonate transmembrane transporter activity IBA --
GO:0015116 sulfate transmembrane transporter activity IEA,IBA --
GO:0015297 antiporter activity IEA --
genes like me logo Genes that share ontologies with SLC26A10: view
genes like me logo Genes that share phenotypes with SLC26A10: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC26A10 Gene

Localization for SLC26A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC26A10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC26A10 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SLC26A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC26A10: view

Pathways & Interactions for SLC26A10 Gene

SuperPathways for SLC26A10 Gene

No Data Available

Interacting Proteins for SLC26A10 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: Q8NG04-S2610_HUMAN ENSP00000320217 for SLC26A10 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SLC26A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008272 sulfate transport IEA --
GO:0015701 bicarbonate transport IBA --
GO:0019532 oxalate transport IEA --
GO:0042391 regulation of membrane potential IBA --
genes like me logo Genes that share ontologies with SLC26A10: view

No data available for Pathways by source and SIGNOR curated interactions for SLC26A10 Gene

Drugs & Compounds for SLC26A10 Gene

(2) Additional Compounds for SLC26A10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
Hydrogen carbonate
  • Bicarbonate
  • Bicarbonate (HCO3-)
  • Bicarbonate anion
  • Bicarbonate ion
  • Bicarbonate ion (HCO31-)
genes like me logo Genes that share compounds with SLC26A10: view

Transcripts for SLC26A10 Gene

Unigene Clusters for SLC26A10 Gene

Solute carrier family 26, member 10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A10 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^
SP1: - -
SP2: - -
SP4: -
SP6: - - - - - - -
SP7: - - -
SP8: -

ExUns: 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33
SP3: - -

Relevant External Links for SLC26A10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC26A10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC26A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC26A10 Gene

This gene is overexpressed in Brain - Cerebellum (x5.8) and Brain - Cerebellar Hemisphere (x4.7).

Protein differential expression in normal tissues from HIPED for SLC26A10 Gene

This gene is overexpressed in Heart (42.6) and Ovary (26.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC26A10 Gene

Protein tissue co-expression partners for SLC26A10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC26A10 Gene:


SOURCE GeneReport for Unigene cluster for SLC26A10 Gene:

genes like me logo Genes that share expression patterns with SLC26A10: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SLC26A10 Gene

Orthologs for SLC26A10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC26A10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC26A10 34
  • 98.4 (n)
(Canis familiaris)
Mammalia SLC26A10 35
  • 84 (a)
(Bos Taurus)
Mammalia SLC26A10 35
  • 71 (a)
(Mus musculus)
Mammalia Slc26a10 35
  • 63 (a)
(Gallus gallus)
Aves -- 35
  • 24 (a)
(Anolis carolinensis)
Reptilia SLC26A10 35
  • 53 (a)
(Danio rerio)
Actinopterygii slc26a10 35
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta Prestin 35
  • 22 (a)
(Caenorhabditis elegans)
Secernentea sulp-7 35
  • 26 (a)
sulp-8 35
  • 26 (a)
sulp-2 35
  • 23 (a)
sulp-4 35
  • 23 (a)
sulp-5 35
  • 23 (a)
sulp-3 35
  • 19 (a)
sulp-6 35
  • 18 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUL1 35
  • 12 (a)
SUL2 35
  • 11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
Species where no ortholog for SLC26A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC26A10 Gene

Gene Tree for SLC26A10 (if available)
Gene Tree for SLC26A10 (if available)

Paralogs for SLC26A10 Gene

(11) SIMAP similar genes for SLC26A10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC26A10: view

Variants for SLC26A10 Gene

Sequence variations from dbSNP and Humsavar for SLC26A10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_045678 A colorectal cancer sample
rs1064308 -- 57,626,149(-) TCATG(G/T)ATTCC nc-transcript-variant, utr-variant-3-prime
rs111352851 -- 57,624,611(+) GGTGG(A/G)CATAG intron-variant, nc-transcript-variant, utr-variant-3-prime
rs111464959 -- 57,621,966(+) CACTT(C/T)CCTTG intron-variant, upstream-variant-2KB
rs111521101 -- 57,622,036(+) CTCAC(A/G)GAGCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC26A10 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV gain+loss 15286789

Variation tolerance for SLC26A10 Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.31; 90.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC26A10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC26A10 Gene

Disorders for SLC26A10 Gene

Relevant External Links for SLC26A10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC26A10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC26A10 Gene

Publications for SLC26A10 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 3 64
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4 64
  4. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 4 64
  5. The SLC26 gene family of multifunctional anion exchangers. (PMID: 12759755) Mount D.B. … Romero M.F. (Pflugers Arch. 2004) 4 64

Products for SLC26A10 Gene

Sources for SLC26A10 Gene

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