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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC26A1 Gene

protein-coding   GIFtS: 54
GCID: GC04M000962

solute carrier family 26 (sulfate transporter), member 1

 Explore 20 diseases affiliated with
SLC26A1 via our new
 Human Malady Compendium 
Biological research products
for SLC26A1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Solute Carrier Family 26 (Sulfate Transporter), Member 11 2     Sulfate Anion Tranporter AT12
SAT-11 2 3     Sulfate Anion Transporter 12
EDM41 2     Sulfate/Anion Transporter SAT-1 Protein2
SAT12 3     Solute Carrier Family 26 Member 13

External Ids:    HGNC: 109931   Entrez Gene: 108612   Ensembl: ENSG000001452177   OMIM: 6101305   UniProtKB: Q9H2B43   

Export aliases for SLC26A1 gene to outside databases

Previous GC identifer: GC04M001015


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC26A1:
This gene is a member of a family of sulfate/anion transporter genes. Family members are well conserved in their
genomic (number and size of exons) and protein (aa length among species) structures, but have markedly different
tissue expression patterns. This gene is primarily expressed in the liver, pancreas, and brain. Three splice variants
that encode different isoforms have been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: S26A1_HUMAN, Q9H2B4
Function: High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_037622.5  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC26A1 gene promoter:
         p53   Nkx2-5   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC26A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC26A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC26A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

SLC26A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC26A1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M000962:  view genomic region     (about GC identifiers)

Start:
972,861 bp from pter      End:
987,228 bp from pter
Size:
14,368 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S26A1_HUMAN, Q9H2B4 (See protein sequence)
Recommended Name: Sulfate anion transporter 1  
Size: 701 amino acids; 75016 Da
Subcellular location: Membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: A8K9N2 Q7Z5R3 Q96BK0
Alternative splicing: 2 isoforms:  Q9H2B4-1   Q9H2B4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC26A1: NX_Q9H2B4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H2B4

  • SLC26A1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_071325.2  NP_602297.1  NP_998778.1  

    ENSEMBL proteins: 
     ENSP00000381532   ENSP00000354721   ENSP00000381528  
    Reactome Protein details: Q9H2B4
    Human Recombinant Protein Products: 
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    Uscn Proteins for SLC26A1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane TAS11087667


    SLC26A1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLC26A1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SLC26A1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR002645 STAS_dom
     IPR018045 S04_transporter_CS
     IPR001902 SulP_transpt
     IPR011547 Sulph_transpt

    Graphical View of Domain Structure for InterPro Entry Q9H2B4

    ProtoNet protein and cluster: Q9H2B4

    1 Blocks protein family: IPB001902 Sulphate transporter

    UniProtKB/Swiss-Prot: S26A1_HUMAN, Q9H2B4
    Similarity: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family
    Similarity: Contains 1 STAS domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: S26A1_HUMAN, Q9H2B4
    Function: High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate

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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008271secondary active sulfate transmembrane transporter activity IEA--
    GO:0015108chloride transmembrane transporter activity IEA--
    GO:0015116sulfate transmembrane transporter activity NAS--
    GO:0019531oxalate transmembrane transporter activity IEA--


    SLC26A1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Slc26a1tm1Mark for SLC26A1
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc26a1):
     cellular  digestive/alimentary  homeostasis/metabolism  immune system  liver/biliary system 
     renal/urinary system 

    SLC26A1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport1.00
    Transmembrane transport of small molecules0.50
    2Multifunctional anion exchangers
    Multifunctional anion exchangers1.00
    3Amino acid and oligopeptide SLC transporters
    Transport of inorganic cations/anions and amino acids/oligopeptides0.52

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for SLC26A1
        Multifunctional anion exchangers
    SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of inorganic cations/anions and amino acids/oligopeptides



    SLC26A1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC26A1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLC26A1 (Q9H2B43 ENSP000003547214) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006821chloride transport ----
    GO:0008272sulfate transport NAS--
    GO:0019532oxalate transport ----
    GO:0055085transmembrane transport TAS--


    SLC26A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC26A1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SLC26A1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    N1,N11-Diethylnorspermine tetrahydrochloride Spermine and spermidine acetyltransferase potentiator[121749-39-1]
    6 Novoseek chemical compound relationships for SLC26A1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oxalate 75.7 5 20160351 (2), 15720248 (1), 12605306 (1)
    sulfate 69.1 14 12713736 (2), 20160351 (2), 12605306 (2), 15720248 (1) (see all 6)
    iodide 58.3 1 15720248 (1)
    formate 52.3 1 15720248 (1)
    chloride 46.9 1 15720248 (1)
    bicarbonate 40.1 1 15720248 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC26A1 / S26A1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC26A1 gene (3 alternative transcripts): 
    NM_022042.2  NM_134425.1  NM_213613.2  

    Unigene Cluster for SLC26A1:

    Solute carrier family 26 (sulfate transporter), member 1
    Hs.658244  [show with all ESTs]
    Unigene Representative Sequence: AY124771
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398520(uc003gbx.3) ENST00000361661(uc003gcb.3 uc003gcc.3)
    ENST00000398516 ENST00000513138

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    Additional cDNA sequence: 

    AF297659.2 AK292747.1 AY124771.1 BC015517.2 

    6 DOTS entries:

    DT.101977060  DT.40188696  DT.91974331  DT.97833470  DT.95211433  DT.100748479 

    16 AceView cDNA sequences:

    BC015517 BM789616 NM_134425 AY124771 NM_022042 NM_213613 AF297659 BM855382 
    BF589989 AI651437 BE787840 BU185680 BQ446374 BG910609 R97279 BI761189 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC26A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTAGTGGGCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    SLC26A1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC26A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC26A1

    SOURCE GeneReport for Unigene cluster: Hs.658244

    UniProtKB/Swiss-Prot: S26A1_HUMAN, Q9H2B4
    Tissue specificity: Expressed most abundantly in the kidney and liver, with lower levels in the pancreas, testis,
    brain, small intestine, colon, and lung

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC26A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLC26A1 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SLC26A16
    --
    --
    54(a)
    43(a)
    1 ↔ 1
    possible ortholog
    Z(52449898-52453422)
    Un(55372749-55375680)
    lizard
    (Anolis carolinensis)
    Reptilia SLC26A16
    --
    56(a)
    1 ↔ 1
    GL343201.1(947077-951292)
    zebrafish
    (Danio rerio)
    Actinopterygii slc26a11 solute carrier family 26 (sulfate transporter), member more 55.01(n)
    51.35(a)
      791185  NM_001080667.1  NP_001074136.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG54853 high affinity sulfate permease 30(a)   75A9   --
    worm
    (Caenorhabditis elegans)
    Secernentea W04G3.63
    sulp-21
    dra like protein3
    Protein SULP-21
    33(a)
    (best of 6)3
    39.98(n)1
    30.66(a)1
      X(11115908-11117663)3
    1808281  NM_076543.31  NP_508944.11 


    ENSEMBL Gene Tree for SLC26A1 (if available)
    TreeFam Gene Tree for SLC26A1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC26A1 gene
    SLC26A92  SLC26A32  SLC26A102  SLC26A72  SLC26A62  SLC26A42  SLC26A52  SLC26A22  
    SLC26A112  SLC26A82  
    12 SIMAP similar genes for SLC26A1 using alignment to 2 protein entries:     S26A1_HUMAN (see all proteins):
    SLC26A2    DKFZp686P10213    SLC26A5    SLC26A10    SLC26A4    GPAT2
    LOC150763    PRES    SLC26A3    RESDA1    SLC26A6    SLC26A9

    SLC26A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for SLC26A1
         4 CNVs: 30190 30187 30189 30188
    Human Gene Mutation Database (HGMD): SLC26A1
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC26A1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SLC26A1 for disorders           About GeneDecksing

    OMIM gene information: 610130    OMIM disorders: --

    20 diseases for SLC26A1:    About MalaCards
    epiphyseal dysplasia    multiple epiphyseal dysplasia    renal tubular acidosis    diastrophic dysplasia
    primary hyperoxaluria    atelosteogenesis    achondrogenesis    urolithiasis
    fanconi's anemia    nephrocalcinosis    nephrolithiasis    fainting
    anemia    colon cancer    pharyngitis    tuberculosis
    pancreatitis    malaria    neuronitis    mycobacterium tuberculosis

    2 diseases from the University of Copenhagen DISEASES database for SLC26A1:
    Primary hyperoxaluria     Nephrolithiasis

    Export disorders for SLC26A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC26A1 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with SLC26A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human sulfate anion transporter (hsat-1) protein and gene (SAT1; SLC26A1). (PubMed id 12713736)1, 2, 9 Regeer R.R.... Markovich D. (2003)
    2. Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger. (PubMed id 11087667)1, 2 Lohi H....Kere J. (2000)
    3. Glyoxylate is a substrate of the sulfate-oxalate exch anger, sat-1, and increases its expression in HepG2 cells. (PubMed id 21093948)1 Schnedler N....Burckhardt B.C. (2011)
    4. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (2009)
    5. Familial pure proximal renal tubular acidosis--a clinical and genetic study. (PubMed id 17881426)1 Katzir Z....Holtzman E. (2008)
    6. Evaluation of SAT-1, SAT-2 and GalNAcT-1 mRNA in colon cancer by real-time PCR. (PubMed id 17119850)1 Gornati R....Bernardini G. (2007)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10861 HGNC: 10993 AceView: SLC26A1 Ensembl:ENSG00000145217 euGenes: HUgn10861
    ECgene: SLC26A1 H-InvDB: SLC26A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC26A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC26A1 gene:
    Search GeneIP for patents involving SLC26A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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