Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC26A1 Gene

Aliases for SLC26A1 Gene

  • Solute Carrier Family 26 (Anion Exchanger), Member 1 2 3
  • SAT1 3 4 6
  • Solute Carrier Family 26 (Sulfate Transporter), Member 1 2 3
  • SAT-1 3 4
  • Sulfate/Anion Transporter SAT-1 Protein 3
  • Solute Carrier Family 26 Member 1 4
  • Sulfate Anion Tranporter AT1 3
  • Sulfate Anion Transporter 1 3
  • SLC25A1 6
  • EDM4 3

External Ids for SLC26A1 Gene

Previous GeneCards Identifiers for SLC26A1 Gene

  • GC04M001015

Summaries for SLC26A1 Gene

Entrez Gene Summary for SLC26A1 Gene

  • This gene is a member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures, but have markedly different tissue expression patterns. This gene is primarily expressed in the liver, pancreas, and brain. Three splice variants that encode different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC26A1 Gene

SLC26A1 (Solute Carrier Family 26 (Anion Exchanger), Member 1) is a Protein Coding gene. Diseases associated with SLC26A1 include proximal renal tubular acidosis and mucopolysaccharidoses. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include secondary active sulfate transmembrane transporter activity and chloride transmembrane transporter activity. An important paralog of this gene is SLC26A2.

UniProtKB/Swiss-Prot for SLC26A1 Gene

  • High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate. Mediates sulfate and oxalate transport.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC26A1 Gene

Genomics for SLC26A1 Gene

Regulatory Elements for SLC26A1 Gene

Transcription factor binding sites by QIAGEN in the SLC26A1 gene promoter:

Genomic Location for SLC26A1 Gene

Start:
979,073 bp from pter
End:
994,198 bp from pter
Size:
15,126 bases
Orientation:
Minus strand

Genomic View for SLC26A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC26A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC26A1 Gene

Proteins for SLC26A1 Gene

  • Protein details for SLC26A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2B4-S26A1_HUMAN
    Recommended name:
    Sulfate anion transporter 1
    Protein Accession:
    Q9H2B4
    Secondary Accessions:
    • A8K9N2
    • Q7Z5R3
    • Q96BK0

    Protein attributes for SLC26A1 Gene

    Size:
    701 amino acids
    Molecular mass:
    75016 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC26A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC26A1 Gene

Proteomics data for SLC26A1 Gene at MOPED

Post-translational modifications for SLC26A1 Gene

  • Glycosylation at Asn158 and Asn163
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC26A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC26A1 Gene

Domains for SLC26A1 Gene

Gene Families for SLC26A1 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC26A1 Gene

Suggested Antigen Peptide Sequences for SLC26A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H2B4

UniProtKB/Swiss-Prot:

S26A1_HUMAN :
  • Q9H2B4
Domain:
  • Contains 1 STAS domain.
Family:
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
genes like me logo Genes that share domains with SLC26A1: view

Function for SLC26A1 Gene

Molecular function for SLC26A1 Gene

UniProtKB/Swiss-Prot Function: High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate. Mediates sulfate and oxalate transport.

Gene Ontology (GO) - Molecular Function for SLC26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008271 secondary active sulfate transmembrane transporter activity IEA --
GO:0015108 chloride transmembrane transporter activity ISS --
GO:0015116 sulfate transmembrane transporter activity ISS --
GO:0015301 anion:anion antiporter activity ISS --
GO:0019531 oxalate transmembrane transporter activity ISS --
genes like me logo Genes that share ontologies with SLC26A1: view
genes like me logo Genes that share phenotypes with SLC26A1: view

Animal Models for SLC26A1 Gene

MGI Knock Outs for SLC26A1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC26A1 Gene

Localization for SLC26A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC26A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC26A1 Gene COMPARTMENTS Subcellular localization image for SLC26A1 gene
Compartment Confidence
plasma membrane 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane TAS 11087667
genes like me logo Genes that share ontologies with SLC26A1: view

Pathways for SLC26A1 Gene

genes like me logo Genes that share pathways with SLC26A1: view

Gene Ontology (GO) - Biological Process for SLC26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006805 xenobiotic metabolic process TAS --
GO:0006811 ion transport TAS --
GO:0006821 chloride transport ISS --
GO:0008272 sulfate transport ISS --
genes like me logo Genes that share ontologies with SLC26A1: view

Compounds for SLC26A1 Gene

(6) Novoseek inferred chemical compound relationships for SLC26A1 Gene

Compound -log(P) Hits PubMed IDs
oxalate 75.7 4
sulfate 69.1 9
iodide 58.3 1
formate 52.3 1
chloride 46.9 1
genes like me logo Genes that share compounds with SLC26A1: view

Transcripts for SLC26A1 Gene

mRNA/cDNA for SLC26A1 Gene

Unigene Clusters for SLC26A1 Gene

Solute carrier family 26 (sulfate transporter), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A1 Gene

No ASD Table

Relevant External Links for SLC26A1 Gene

GeneLoc Exon Structure for
SLC26A1
ECgene alternative splicing isoforms for
SLC26A1

Expression for SLC26A1 Gene

mRNA expression in normal human tissues for SLC26A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC26A1 Gene

SOURCE GeneReport for Unigene cluster for SLC26A1 Gene Hs.658244

mRNA Expression by UniProt/SwissProt for SLC26A1 Gene

Q9H2B4-S26A1_HUMAN
Tissue specificity: Expressed most abundantly in the kidney and liver, with lower levels in the pancreas, testis, brain, small intestine, colon, and lung.
genes like me logo Genes that share expressions with SLC26A1: view

No data available for mRNA differential expression in normal tissues for SLC26A1 Gene

Orthologs for SLC26A1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC26A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC26A1 35
  • 98.43 (n)
  • 98.43 (a)
SLC26A1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC26A1 35
  • 83.74 (n)
  • 79.6 (a)
SLC26A1 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC26A1 35
  • 83.79 (n)
  • 80.46 (a)
SLC26A1 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc26a1 35
  • 77.22 (n)
  • 79.23 (a)
Slc26a1 16
Slc26a1 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC26A1 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC26A1 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc26a1 35
  • 77.7 (n)
  • 78.65 (a)
chicken
(Gallus gallus)
Aves SLC26A1 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC26A1 36
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc26a1 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Prestin 36
  • 27 (a)
OneToMany
CG5485 37
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea sulp-2 35
  • 40.08 (n)
  • 30.1 (a)
sulp-2 36
  • 27 (a)
ManyToMany
sulp-3 36
  • 23 (a)
ManyToMany
sulp-4 36
  • 26 (a)
ManyToMany
sulp-5 36
  • 27 (a)
ManyToMany
sulp-6 36
  • 22 (a)
ManyToMany
sulp-7 36
  • 31 (a)
ManyToMany
sulp-8 36
  • 30 (a)
ManyToMany
K12G11.2 37
  • 29 (a)
W04G3.6 37
  • 33 (a)
F14D12.5 37
  • 27 (a)
ZK287.2 37
  • 29 (a)
W01B11.2 37
  • 29 (a)
K12G11.1 37
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUL1 36
  • 16 (a)
ManyToMany
SUL2 36
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
Species with no ortholog for SLC26A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC26A1 Gene

ENSEMBL:
Gene Tree for SLC26A1 (if available)
TreeFam:
Gene Tree for SLC26A1 (if available)

Paralogs for SLC26A1 Gene

Selected SIMAP similar genes for SLC26A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC26A1: view

Variants for SLC26A1 Gene

Sequence variations from dbSNP and Humsavar for SLC26A1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4583705 -- 979,248(+) GGCTT(C/T)TCTCC utr-variant-3-prime
rs4690163 -- 981,349(+) gctca(C/T)gcctg intron-variant
rs4690219 -- 983,482(+) cagga(A/G)ggaga intron-variant
rs6814300 -- 981,839(+) gagac(A/G)gagtc intron-variant
rs6814642 -- 984,600(+) ccgag(A/G)caggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC26A1 Gene

Variant ID Type Subtype PubMed ID
nsv822425 CNV Loss 20364138
dgv5390n71 CNV Loss 21882294
dgv5391n71 CNV Loss 21882294
nsv469998 CNV Loss 18288195
dgv5395n71 CNV Loss 21882294
nsv878286 CNV Gain 21882294
nsv878287 CNV Loss 21882294
dgv5396n71 CNV Loss 21882294
dgv5397n71 CNV Loss 21882294
nsv878292 CNV Loss 21882294
nsv4196 CNV Loss 18451855
nsv822428 CNV Gain 20364138
nsv878310 CNV Loss 21882294
dgv5398n71 CNV Loss 21882294
nsv878315 CNV Loss 21882294
nsv482086 CNV Gain 20164927

Relevant External Links for SLC26A1 Gene

HapMap Linkage Disequilibrium report
SLC26A1
Human Gene Mutation Database (HGMD)
SLC26A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC26A1 Gene

Disorders for SLC26A1 Gene

(2) University of Copenhagen DISEASES for SLC26A1 Gene

genes like me logo Genes that share disorders with SLC26A1: view

No data available for UniProtKB/Swiss-Prot for SLC26A1 Gene

Publications for SLC26A1 Gene

  1. Characterization of the human sulfate anion transporter (hsat-1) protein and gene (SAT1; SLC26A1). (PMID: 12713736) Regeer R.R. … Markovich D. (DNA Cell Biol. 2003) 3 4 23
  2. Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger. (PMID: 11087667) Lohi H. … Kere J. (Genomics 2000) 3 4
  3. Physiological roles and regulation of mammalian sulfate transporters. (PMID: 11581495) Markovich D. (Physiol. Rev. 2001) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Evaluation of SAT-1, SAT-2 and GalNAcT-1 mRNA in colon cancer by real-time PCR. (PMID: 17119850) Gornati R. … Bernardini G. (Mol. Cell. Biochem. 2007) 3

Products for SLC26A1 Gene

Sources for SLC26A1 Gene

Back to Top

Content