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Aliases for SLC25A6 Gene

Aliases for SLC25A6 Gene

  • Solute Carrier Family 25 Member 6 2 3 4
  • Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 6 2 3
  • Adenine Nucleotide Translocator 3 3 4
  • ADP,ATP Carrier Protein 3 3 4
  • ANT 2 3 4
  • ANT 3 3 4
  • ANT3 3 4
  • Solute Carrier Family 25 (Mitochondrial Carrier Adenine Nucleotide Translocator), Member 6 5
  • ADP,ATP Carrier Protein, Isoform T2 4
  • ADP,ATP Carrier Protein, Liver 3
  • ADP/ATP Translocator Of Liver 3
  • ADP,ATP Carrier Protein 3
  • ANT3Y 3
  • AAC3 3
  • ANT 3

External Ids for SLC25A6 Gene

Previous HGNC Symbols for SLC25A6 Gene

  • ANT3

Previous GeneCards Identifiers for SLC25A6 Gene

  • GC0XM000980
  • GC0XM000821
  • GC0XM001081
  • GC0XM001150
  • GC0YM001548
  • GC0XM001548
  • GC0XM001465
  • GC0XM001505

Summaries for SLC25A6 Gene

Entrez Gene Summary for SLC25A6 Gene

  • This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013]

GeneCards Summary for SLC25A6 Gene

SLC25A6 (Solute Carrier Family 25 Member 6) is a Protein Coding gene. Diseases associated with SLC25A6 include Influenza and Autosomal Dominant Progressive External Ophthalmoplegia. Among its related pathways are HTLV-I infection and Regulation of Glucokinase by Glucokinase Regulatory Protein. GO annotations related to this gene include transporter activity and ATP:ADP antiporter activity. An important paralog of this gene is SLC25A5.

UniProtKB/Swiss-Prot for SLC25A6 Gene

  • Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.

Gene Wiki entry for SLC25A6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A6 Gene

Genomics for SLC25A6 Gene

Regulatory Elements for SLC25A6 Gene

Enhancers for SLC25A6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC25A6 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC25A6 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A6 Gene

Chromosome:
X
Start:
1,386,152 bp from pter
End:
1,392,724 bp from pter
Size:
6,573 bases
Orientation:
Minus strand

Genomic View for SLC25A6 Gene

Genes around SLC25A6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A6 Gene

Proteins for SLC25A6 Gene

  • Protein details for SLC25A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12236-ADT3_HUMAN
    Recommended name:
    ADP/ATP translocase 3
    Protein Accession:
    P12236
    Secondary Accessions:
    • Q96C49

    Protein attributes for SLC25A6 Gene

    Size:
    298 amino acids
    Molecular mass:
    32866 Da
    Quaternary structure:
    • Found in a complex with ARL2, ARL2BP and SLC25A6 (By similarity). Homodimer. Interacts with influenza A virus PB1-F2 protein and HIV-1 Vpr.
    Miscellaneous:
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
    • The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).

neXtProt entry for SLC25A6 Gene

Proteomics data for SLC25A6 Gene at MOPED

Post-translational modifications for SLC25A6 Gene

  • Ubiquitination at Lys 43, Lys 105, Lys 147, and Lys 163
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC25A6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A6 Gene

Domains & Families for SLC25A6 Gene

Graphical View of Domain Structure for InterPro Entry

P12236

UniProtKB/Swiss-Prot:

ADT3_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A6: view

Function for SLC25A6 Gene

Molecular function for SLC25A6 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.

Gene Ontology (GO) - Molecular Function for SLC25A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21370995
genes like me logo Genes that share ontologies with SLC25A6: view
genes like me logo Genes that share phenotypes with SLC25A6: view

Animal Model Products

miRNA for SLC25A6 Gene

miRTarBase miRNAs that target SLC25A6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A6 Gene

Localization for SLC25A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A6 Gene

Mitochondrion inner membrane; Multi-pass membrane protein. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A6 Gene COMPARTMENTS Subcellular localization image for SLC25A6 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SLC25A6 Gene

Pathways & Interactions for SLC25A6 Gene

genes like me logo Genes that share pathways with SLC25A6: view

Pathways by source for SLC25A6 Gene

Gene Ontology (GO) - Biological Process for SLC25A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0006412 translation IBA --
GO:0006915 apoptotic process IEA --
GO:0015853 adenine transport TAS --
GO:0015866 ADP transport NAS 2541251
genes like me logo Genes that share ontologies with SLC25A6: view

No data available for SIGNOR curated interactions for SLC25A6 Gene

Drugs & Compounds for SLC25A6 Gene

(3) Drugs for SLC25A6 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clodronate Approved, Investigational Pharma inhibitor, Target 0

(1) Additional Compounds for SLC25A6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC25A6: view

Transcripts for SLC25A6 Gene

Unigene Clusters for SLC25A6 Gene

Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b ^ 6a · 6b
SP1: - - - - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: - - - -
SP7: -
SP8: - - -
SP9:

Relevant External Links for SLC25A6 Gene

GeneLoc Exon Structure for
SLC25A6
ECgene alternative splicing isoforms for
SLC25A6

Expression for SLC25A6 Gene

mRNA expression in normal human tissues for SLC25A6 Gene

Protein differential expression in normal tissues from HIPED for SLC25A6 Gene

This gene is overexpressed in Nasal epithelium (13.2), Brain (7.6), and Frontal cortex (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A6 Gene



SOURCE GeneReport for Unigene cluster for SLC25A6 Gene Hs.350927

genes like me logo Genes that share expression patterns with SLC25A6: view

Protein tissue co-expression partners for SLC25A6 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC25A6 Gene

Orthologs for SLC25A6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC25A6 35
  • 91.61 (n)
  • 97.65 (a)
SLC25A6 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A6 35
  • 91.14 (n)
  • 96.68 (a)
SLC25A6 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a6 35
  • 78.49 (n)
  • 89.19 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 97 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A6 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC25A6 35
  • 79.19 (n)
  • 93.29 (a)
-- 36
  • 94 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia SLC25A6 36
  • 88 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc25a6 35
  • 77.07 (n)
  • 91.95 (a)
slc25a6 36
  • 92 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Ant2 37
  • 74 (a)
sesB 37
  • 79 (a)
Ant2 35
  • 71.51 (n)
  • 75.09 (a)
Ant2 36
  • 71 (a)
ManyToMany
sesB 36
  • 76 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta ADT1_ANOGA 35
  • 72.93 (n)
  • 78.52 (a)
worm
(Caenorhabditis elegans)
Secernentea C47E12.2 37
  • 50 (a)
F25B4.7 37
  • 48 (a)
K01H12.2 37
  • 70 (a)
R07E3.4 37
  • 45 (a)
T01B11.4 37
  • 70 (a)
W02D3.6 37
  • 66 (a)
ant-1.3 35
  • 66.55 (n)
  • 71.87 (a)
ant-1.2 36
  • 65 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAC1 36
  • 50 (a)
ManyToMany
AAC3 36
  • 52 (a)
ManyToMany
PET9 36
  • 50 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2354 36
  • 54 (a)
ManyToMany
Species with no ortholog for SLC25A6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC25A6 Gene

ENSEMBL:
Gene Tree for SLC25A6 (if available)
TreeFam:
Gene Tree for SLC25A6 (if available)

Paralogs for SLC25A6 Gene

Paralogs for SLC25A6 Gene

(8) SIMAP similar genes for SLC25A6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC25A6: view

Variants for SLC25A6 Gene

Sequence variations from dbSNP and Humsavar for SLC25A6 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_054819 -

Structural Variations from Database of Genomic Variants (DGV) for SLC25A6 Gene

Variant ID Type Subtype PubMed ID
esv29996 CNV Loss 17803354
esv21933 CNV Gain+Loss 19812545
dgv1357e201 CNV Deletion 23290073
esv2666429 CNV Deletion 23128226

Variation tolerance for SLC25A6 Gene

Residual Variation Intolerance Score: 2.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.01; 60.28% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC25A6 Gene

Disorders for SLC25A6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC25A6 Gene - From: GeneCards

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC25A6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A6
genes like me logo Genes that share disorders with SLC25A6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC25A6 Gene

Publications for SLC25A6 Gene

  1. Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1. (PMID: 16201016) Zamarin D. … Palese P. (PLoS Pathog. 2005) 3 4 67
  2. Molecular interactions between mitochondrial membrane proteins and the C-terminal domain of PB1-F2: an in silico approach. (PMID: 19669810) Danishuddin M. … Khan A.U. (J Mol Model 2010) 3 23
  3. Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 cells. (PMID: 17855512) Yang Z. … Gu J. (Mol. Biol. Cell 2007) 3 23
  4. IL-4-induced upregulation of adenine nucleotide translocase 3 and its role in Th cell survival from apoptosis. (PMID: 16930576) Jang J.Y. … Lee C.E. (Cell. Immunol. 2006) 3 23
  5. Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured cells. (PMID: 15063741) Zamora M. … ViA+as O. (FEBS Lett. 2004) 3 23

Products for SLC25A6 Gene

Sources for SLC25A6 Gene

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