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Aliases for SLC25A6 Gene

Aliases for SLC25A6 Gene

  • Solute Carrier Family 25 Member 6 2 3 4 5
  • Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 6 2 3
  • Adenine Nucleotide Translocator 3 3 4
  • ADP,ATP Carrier Protein 3 3 4
  • ANT 2 3 4
  • ANT 3 3 4
  • ANT3 3 4
  • ADP,ATP Carrier Protein, Isoform T2 4
  • ADP,ATP Carrier Protein, Liver 3
  • ADP/ATP Translocator Of Liver 3
  • ADP,ATP Carrier Protein 3
  • ADP/ATP Translocase 3 3
  • ANT3Y 3
  • AAC3 3
  • ANT 3

External Ids for SLC25A6 Gene

Previous HGNC Symbols for SLC25A6 Gene

  • ANT3

Previous GeneCards Identifiers for SLC25A6 Gene

  • GC0XM000980
  • GC0XM000821
  • GC0XM001081
  • GC0XM001150
  • GC0YM001548
  • GC0XM001548
  • GC0XM001465
  • GC0XM001505

Summaries for SLC25A6 Gene

Entrez Gene Summary for SLC25A6 Gene

  • This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013]

GeneCards Summary for SLC25A6 Gene

SLC25A6 (Solute Carrier Family 25 Member 6) is a Protein Coding gene. Diseases associated with SLC25A6 include Influenza and Autosomal Dominant Progressive External Ophthalmoplegia. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Integration of energy metabolism. GO annotations related to this gene include transporter activity and ATP:ADP antiporter activity. An important paralog of this gene is SLC25A5.

UniProtKB/Swiss-Prot for SLC25A6 Gene

  • Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.

Gene Wiki entry for SLC25A6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A6 Gene

Genomics for SLC25A6 Gene

Regulatory Elements for SLC25A6 Gene

Enhancers for SLC25A6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG001500 1.5 FANTOM5 Ensembl dbSUPER 1.8 -110.4 -110377 5.0 HDGF PKNOX1 ATF1 CREB3L1 ZNF48 ZNF121 ZNF766 GATA2 ELK1 ZNF207 P2RY8 AKAP17A CSF2RA IL3RA ASMTL ASMT CRLF2 SLC25A6
GH0XG001247 1.2 FANTOM5 Ensembl 2.2 +143.5 143540 2.4 TBP ETS1 ZNF121 ZNF366 FOS ETV6 USF2 REST NR2F2 RAD51 CSF2RA IL3RA ASMTL AKAP17A CRLF2 ASMT P2RY8 SLC25A6
GH0XG001316 0.9 FANTOM5 Ensembl 2.7 +76.0 76024 1.0 SCRT1 CTCF POLR2A ZNF366 CSF2RA IL3RA ASMTL AKAP17A ASMT SLC25A6 P2RY8 CRLF2 GC0XM001318 RNA5SP498
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A6 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000243759 324 2401 MLX CREB3L1 AGO1 ZFP64 YBX1 DMAP1 ZNF143 ZNF263 SP3 NFYC

Genomic Location for SLC25A6 Gene

1,386,152 bp from pter
1,392,724 bp from pter
6,573 bases
Minus strand

Genomic View for SLC25A6 Gene

Genes around SLC25A6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A6 Gene

Proteins for SLC25A6 Gene

  • Protein details for SLC25A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP/ATP translocase 3
    Protein Accession:
    Secondary Accessions:
    • Q96C49

    Protein attributes for SLC25A6 Gene

    298 amino acids
    Molecular mass:
    32866 Da
    Quaternary structure:
    • Found in a complex with ARL2, ARL2BP and SLC25A6 (By similarity). Homodimer. Interacts with influenza A virus PB1-F2 protein and HIV-1 Vpr.
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
    • The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).

neXtProt entry for SLC25A6 Gene

Post-translational modifications for SLC25A6 Gene

  • Ubiquitination at isoforms=43, isoforms=105, isoforms=147, and isoforms=163
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC25A6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A6 Gene

Domains & Families for SLC25A6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A6: view

Function for SLC25A6 Gene

Molecular function for SLC25A6 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.

Gene Ontology (GO) - Molecular Function for SLC25A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005471 ATP:ADP antiporter activity NAS 2541251
GO:0005515 protein binding IPI 21370995
GO:0015207 adenine transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLC25A6: view
genes like me logo Genes that share phenotypes with SLC25A6: view

Animal Model Products

miRNA for SLC25A6 Gene

miRTarBase miRNAs that target SLC25A6

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A6 Gene

Localization for SLC25A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A6 Gene

Mitochondrion inner membrane; Multi-pass membrane protein. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A6 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC25A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IEA,IDA 20833797
GO:0005743 mitochondrial inner membrane TAS --
GO:0005744 mitochondrial inner membrane presequence translocase complex TAS 2541251
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC25A6: view

Pathways & Interactions for SLC25A6 Gene

genes like me logo Genes that share pathways with SLC25A6: view

Pathways by source for SLC25A6 Gene

Gene Ontology (GO) - Biological Process for SLC25A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS --
GO:0006810 transport IEA --
GO:0006915 apoptotic process IEA --
GO:0015853 adenine transport IEA --
GO:0015866 ADP transport IEA --
genes like me logo Genes that share ontologies with SLC25A6: view

No data available for SIGNOR curated interactions for SLC25A6 Gene

Drugs & Compounds for SLC25A6 Gene

(4) Drugs for SLC25A6 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clodronate Approved, Investigational, Vet_approved Pharma inhibitor, Target 0
Atractyloside Dipotassium Salt Pharma ANT inhibitor 0

(1) Additional Compounds for SLC25A6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for SLC25A6 Gene

Compound Action Cas Number
Atractyloside Dipotassium Salt ANT inhibitor 102130-43-8
genes like me logo Genes that share compounds with SLC25A6: view

Drug Products

Transcripts for SLC25A6 Gene

Unigene Clusters for SLC25A6 Gene

Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b ^ 6a · 6b
SP1: - - - - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: - - - -
SP7: -
SP8: - - -

Relevant External Links for SLC25A6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC25A6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A6 Gene

Protein differential expression in normal tissues from HIPED for SLC25A6 Gene

This gene is overexpressed in Nasal epithelium (13.2), Brain (7.6), and Frontal cortex (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC25A6 Gene

Protein tissue co-expression partners for SLC25A6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC25A6 Gene:


SOURCE GeneReport for Unigene cluster for SLC25A6 Gene:


Evidence on tissue expression from TISSUES for SLC25A6 Gene

  • Lung(5)
  • Nervous system(5)
  • Eye(4.9)
  • Liver(4.9)
  • Intestine(4.4)
  • Muscle(4.3)
  • Skin(4.3)
  • Pancreas(4)
  • Stomach(4)
  • Kidney(3.7)
  • Blood(3.6)
  • Heart(3.2)
  • Spleen(2.2)
  • Thyroid gland(2.2)
  • Adrenal gland(2)
  • Bone(2)
  • Bone marrow(2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with SLC25A6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A6 Gene

Orthologs for SLC25A6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A6 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia -- 35
  • 97 (a)
(Bos Taurus)
Mammalia SLC25A6 34 35
  • 91.61 (n)
(Canis familiaris)
Mammalia SLC25A6 34 35
  • 91.14 (n)
(Rattus norvegicus)
Mammalia Slc25a6 34
  • 78.49 (n)
(Ornithorhynchus anatinus)
Mammalia SLC25A6 35
  • 74 (a)
(Gallus gallus)
Aves -- 35
  • 94 (a)
SLC25A6 34
  • 79.19 (n)
(Anolis carolinensis)
Reptilia SLC25A6 35
  • 88 (a)
(Danio rerio)
Actinopterygii slc25a6 34 35
  • 77.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta sesB 36 35
  • 79 (a)
Ant2 36 34 35
  • 71.51 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta ADT1_ANOGA 34
  • 72.93 (n)
(Caenorhabditis elegans)
Secernentea K01H12.2 36
  • 70 (a)
T01B11.4 36
  • 70 (a)
ant-1.3 34
  • 66.55 (n)
W02D3.6 36
  • 66 (a)
ant-1.2 35
  • 65 (a)
C47E12.2 36
  • 50 (a)
F25B4.7 36
  • 48 (a)
R07E3.4 36
  • 45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAC3 35
  • 52 (a)
AAC1 35
  • 50 (a)
PET9 35
  • 50 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2354 35
  • 54 (a)
Species where no ortholog for SLC25A6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC25A6 Gene

Gene Tree for SLC25A6 (if available)
Gene Tree for SLC25A6 (if available)

Paralogs for SLC25A6 Gene

Paralogs for SLC25A6 Gene

(8) SIMAP similar genes for SLC25A6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC25A6: view

Variants for SLC25A6 Gene

Sequence variations from dbSNP and Humsavar for SLC25A6 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1055341021 -- 1,386,652(+) GCCCC(A/C)CATGC reference, missense
rs111324409 -- 1,391,690(+) CCGCC(A/G)GGCCC intron-variant, upstream-variant-2KB
rs111338474 -- 1,388,330(+) AAATG(C/G)ACTAA intron-variant
rs11211819 -- 1,386,577(-) ACACA(A/C/T)ACACA utr-variant-3-prime
rs112264344 -- 1,390,908(+) AGTGC(G/T)GGGAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC25A6 Gene

Variant ID Type Subtype PubMed ID
dgv1299e201 CNV deletion 23290073
esv21933 CNV gain+loss 19812545
esv2666429 CNV deletion 23128226
esv29996 CNV loss 17803354
nsv1115920 CNV duplication 24896259

Variation tolerance for SLC25A6 Gene

Residual Variation Intolerance Score: 2.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.01; 60.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A6 Gene

Disorders for SLC25A6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC25A6 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC25A6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLC25A6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC25A6 Gene

Publications for SLC25A6 Gene

  1. Molecular interactions between mitochondrial membrane proteins and the C-terminal domain of PB1-F2: an in silico approach. (PMID: 19669810) Danishuddin M. … Khan A.U. (J Mol Model 2010) 3 22 64
  2. Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 cells. (PMID: 17855512) Yang Z. … Gu J. (Mol. Biol. Cell 2007) 3 22 64
  3. IL-4-induced upregulation of adenine nucleotide translocase 3 and its role in Th cell survival from apoptosis. (PMID: 16930576) Jang J.Y. … Lee C.E. (Cell. Immunol. 2006) 3 22 64
  4. Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1. (PMID: 16201016) Zamarin D. … Palese P. (PLoS Pathog. 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SLC25A6 Gene

Sources for SLC25A6 Gene

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