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Aliases for SLC25A6 Gene

Aliases for SLC25A6 Gene

  • Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 6 2 3
  • Adenine Nucleotide Translocator 3 3 4
  • Solute Carrier Family 25 Member 6 3 4
  • ADP,ATP Carrier Protein 3 3 4
  • ANT 2 3 4
  • ANT 3 3 4
  • ANT3 3 4
  • ADP,ATP Carrier Protein, Isoform T2 4
  • ADP,ATP Carrier Protein, Liver 3
  • ADP/ATP Translocator Of Liver 3
  • ADP,ATP Carrier Protein 3
  • ADP/ATP Translocase 3 3
  • ANT3Y 3
  • AAC3 3
  • ANT 3
  • 2 3
  • 3 3

External Ids for SLC25A6 Gene

Previous HGNC Symbols for SLC25A6 Gene

  • ANT3

Previous GeneCards Identifiers for SLC25A6 Gene

  • GC0XM000980
  • GC0XM000821
  • GC0XM001081
  • GC0XM001150
  • GC0YM001548
  • GC0XM001548
  • GC0XM001465
  • GC0XM001505

Summaries for SLC25A6 Gene

Entrez Gene Summary for SLC25A6 Gene

  • This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013]

GeneCards Summary for SLC25A6 Gene

SLC25A6 (Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 6) is a Protein Coding gene. Among its related pathways are Disease and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include ATP:ADP antiporter activity. An important paralog of this gene is SLC25A5.

UniProtKB/Swiss-Prot for SLC25A6 Gene

  • Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.

Gene Wiki entry for SLC25A6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A6 Gene

Genomics for SLC25A6 Gene

Regulatory Elements for SLC25A6 Gene

Genomic Location for SLC25A6 Gene

Start:
1,386,152 bp from pter
End:
1,392,724 bp from pter
Size:
6,573 bases
Orientation:
Minus strand

Genomic View for SLC25A6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC25A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A6 Gene

Proteins for SLC25A6 Gene

  • Protein details for SLC25A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12236-ADT3_HUMAN
    Recommended name:
    ADP/ATP translocase 3
    Protein Accession:
    P12236
    Secondary Accessions:
    • Q96C49

    Protein attributes for SLC25A6 Gene

    Size:
    298 amino acids
    Molecular mass:
    32866 Da
    Quaternary structure:
    • Found in a complex with ARL2, ARL2BP and SLC25A6 (By similarity). Homodimer. Interacts with influenza A virus PB1-F2 protein and HIV-1 Vpr.
    Miscellaneous:
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes
    • The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).

neXtProt entry for SLC25A6 Gene

Proteomics data for SLC25A6 Gene at MOPED

Post-translational modifications for SLC25A6 Gene

  • Ubiquitination at Lys43, Lys63, Lys105, Lys147, Lys163, Lys166, Lys245, Lys268, and Lys272
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC25A6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A6 Gene

Domains for SLC25A6 Gene

Gene Families for SLC25A6 Gene

Graphical View of Domain Structure for InterPro Entry

P12236

UniProtKB/Swiss-Prot:

ADT3_HUMAN :
  • P12236
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A6: view

Function for SLC25A6 Gene

Molecular function for SLC25A6 Gene

UniProtKB/Swiss-Prot Function: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.

Gene Ontology (GO) - Molecular Function for SLC25A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005471 ATP:ADP antiporter activity NAS 2541251
GO:0005515 protein binding IPI 21370995
genes like me logo Genes that share ontologies with SLC25A6: view

miRNA for SLC25A6 Gene

miRTarBase miRNAs that target SLC25A6

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC25A6 Gene

Localization for SLC25A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A6 Gene

Mitochondrion inner membrane; Multi-pass membrane protein. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A6 Gene COMPARTMENTS Subcellular localization image for SLC25A6 gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC25A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA 20833797
GO:0005743 mitochondrial inner membrane TAS --
GO:0005744 mitochondrial inner membrane presequence translocase complex TAS 2541251
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC25A6: view

Pathways for SLC25A6 Gene

genes like me logo Genes that share pathways with SLC25A6: view

Pathways by source for SLC25A6 Gene

Gene Ontology (GO) - Biological Process for SLC25A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0006626 protein targeting to mitochondrion TAS --
GO:0006915 apoptotic process IEA --
GO:0015866 ADP transport NAS 2541251
GO:0015867 ATP transport NAS 2541251
genes like me logo Genes that share ontologies with SLC25A6: view

Compounds for SLC25A6 Gene

(1) Drugbank Compounds for SLC25A6 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Clodronate
10596-23-3 target inhibitor

(3) Novoseek inferred chemical compound relationships for SLC25A6 Gene

Compound -log(P) Hits PubMed IDs
adp 67.7 4
atp 55.3 5
cyclosporin a 19.7 1
genes like me logo Genes that share compounds with SLC25A6: view

Transcripts for SLC25A6 Gene

mRNA/cDNA for SLC25A6 Gene

Unigene Clusters for SLC25A6 Gene

Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b ^ 6a · 6b
SP1: - - - - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: - - - -
SP7: -
SP8: - - -
SP9:

Relevant External Links for SLC25A6 Gene

GeneLoc Exon Structure for
SLC25A6
ECgene alternative splicing isoforms for
SLC25A6

Expression for SLC25A6 Gene

mRNA expression in normal human tissues for SLC25A6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A6 Gene

SOURCE GeneReport for Unigene cluster for SLC25A6 Gene Hs.350927

genes like me logo Genes that share expressions with SLC25A6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC25A6 Gene

Orthologs for SLC25A6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC25A6 35
  • 91.61 (n)
  • 97.65 (a)
SLC25A6 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A6 35
  • 91.14 (n)
  • 96.68 (a)
SLC25A6 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 97 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A6 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a6 35
  • 78.49 (n)
  • 89.19 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 94 (a)
ManyToMany
SLC25A6 35
  • 79.19 (n)
  • 93.29 (a)
lizard
(Anolis carolinensis)
Reptilia SLC25A6 36
  • 88 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc25a6 35
  • 77.07 (n)
  • 91.95 (a)
slc25a6 36
  • 92 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta ADT1_ANOGA 35
  • 72.93 (n)
  • 78.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ant2 35
  • 71.51 (n)
  • 75.09 (a)
Ant2 36
  • 71 (a)
ManyToMany
sesB 36
  • 76 (a)
ManyToMany
sesB 37
  • 79 (a)
Ant2 37
  • 74 (a)
worm
(Caenorhabditis elegans)
Secernentea ant-1.2 36
  • 65 (a)
ManyToMany
ant-1.3 35
  • 66.55 (n)
  • 71.87 (a)
W02D3.6 37
  • 66 (a)
F25B4.7 37
  • 48 (a)
T01B11.4 37
  • 70 (a)
R07E3.4 37
  • 45 (a)
C47E12.2 37
  • 50 (a)
K01H12.2 37
  • 70 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAC1 36
  • 50 (a)
ManyToMany
AAC3 36
  • 52 (a)
ManyToMany
PET9 36
  • 50 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2354 36
  • 54 (a)
ManyToMany
Species with no ortholog for SLC25A6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC25A6 Gene

ENSEMBL:
Gene Tree for SLC25A6 (if available)
TreeFam:
Gene Tree for SLC25A6 (if available)

Paralogs for SLC25A6 Gene

Paralogs for SLC25A6 Gene

Selected SIMAP similar genes for SLC25A6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC25A6: view

Variants for SLC25A6 Gene

Sequence variations from dbSNP and Humsavar for SLC25A6 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
VAR_054819 -

Structural Variations from Database of Genomic Variants (DGV) for SLC25A6 Gene

Variant ID Type Subtype PubMed ID
esv29996 CNV Loss 17803354
esv21933 CNV Gain+Loss 19812545
dgv1357e201 CNV Deletion 23290073
esv2666429 CNV Deletion 23128226

Relevant External Links for SLC25A6 Gene

HapMap Linkage Disequilibrium report
SLC25A6
Locus Specific Mutation Databases (LSDB)
SLC25A6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A6 Gene

Disorders for SLC25A6 Gene

No disorders were found for SLC25A6 Gene.

No data available for UniProtKB/Swiss-Prot for SLC25A6 Gene

Publications for SLC25A6 Gene

  1. Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1. (PMID: 16201016) Zamarin D. … Palese P. (PLoS Pathog. 2005) 3 4
  2. A human pseudoautosomal gene encodes the ANT3 ADP/ATP translocase and escapes X-inactivation. (PMID: 8486369) Slim R. … Petit C. (Genomics 1993) 3 23
  3. A human pseudoautosomal gene, ADP/ATP translocase, escapes X-inactivation whereas a homologue on Xq is subject to X-inactivation. (PMID: 8490661) Schiebel K. … Rappold G. (Nat. Genet. 1993) 3 23
  4. Mitochondrial adenine nucleotide translocator 3 is regulated by IL-4 and IFN-gamma via STAT-dependent pathways. (PMID: 14746803) Jang J.Y. … Lee C.E. (Cell. Immunol. 2003) 3 23
  5. Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured cells. (PMID: 15063741) Zamora M. … ViA+as O. (FEBS Lett. 2004) 3 23

Products for SLC25A6 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SLC25A6
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC25A6
  • Block miRNA regulation of SLC25A6 using miScript Target Protectors

Sources for SLC25A6 Gene

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