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SLC25A6 Gene

protein-coding   GIFtS: 62
GCID: GC0XM001505

Solute Carrier Family 25 (Mitochondrial Carrier; Adenine...


(Previous symbol: ANT3)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide
Translocator), Member 61 2
     AAC32
ANT31 2 3     ANT2
Adenine Nucleotide Translocator 32 3     ANT3Y2
Solute Carrier Family 25 Member 62 3     ADP,ATP Carrier Protein2
ADP,ATP Carrier Protein 32 3     ADP,ATP Carrier Protein, Liver2
ANT 22 3     ADP/ATP Translocase 32
ANT 32 3     ADP/ATP Translocator Of Liver2
22     ADP,ATP Carrier Protein, Isoform T23
32     

External Ids:    HGNC: 109921   Entrez Gene: 2932   Ensembl: ENSG000001691007   OMIM: 300151,4030005   UniProtKB: P122363   

Export aliases for SLC25A6 gene to outside databases

Previous GC identifers: GC0XM000980 GC0XM000821 GC0XM001081 GC0XM001150 GC0YM001548 GC0XM001548 GC0XM001465


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC25A6 Gene:
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this
gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP
from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability
transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The
human genome contains several non-transcribed pseudogenes of this gene. (provided by RefSeq, Jun 2013)

GeneCards Summary for SLC25A6 Gene:
SLC25A6 (solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6) is a protein-coding gene. Diseases associated with SLC25A6 include autosomal dominant progressive external ophthalmoplegia, and ophthalmoplegia. GO annotations related to this gene include ATP:ADP antiporter activity. An important paralog of this gene is SLC25A31.

UniProtKB/Swiss-Prot: ADT3_HUMAN, P12236
Function: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner
membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the
release of mitochondrial products that triggers apoptosis

Gene Wiki entry for SLC25A6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_000024.10  NC_018934.2  NT_167201.2  NT_187358.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC25A6 gene promoter:
         PPAR-gamma1   Pax-5   GCNF-1   GCNF   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC25A6 promoter sequence
   Search Chromatin IP Primers for SLC25A6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC25A6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.32 and Yp11.3   Ensembl cytogenetic band:  Xp22.33   HGNC cytogenetic band: Xp22.32 and Yp11.3

SLC25A6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A6 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM001505:  view genomic region     (about GC identifiers)

Start:
1,505,045 bp from pter      End:
1,511,617 bp from pter
Size:
6,573 bases      Orientation:
minus strand

1 alternative location:
ChrY- 1,455,045-1,461,039     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ADT3_HUMAN, P12236 (See protein sequence)
Recommended Name: ADP/ATP translocase 3  
Size: 298 amino acids; 32866 Da
Subunit: Found in a complex with ARL2, ARL2BP and SLC25A6 (By similarity). Homodimer. Interacts with influenza A
virus PB1-F2 protein and HIV-1 Vpr
Miscellaneous: The transmembrane helices are not perpendicular to the plane of the membrane, but cross the
membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved
proline residue (By similarity)
Miscellaneous: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y
chromosomes
Secondary accessions: Q96C49

Explore the universe of human proteins at neXtProt for SLC25A6: NX_P12236

Explore proteomics data for SLC25A6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys43, Lys63, Lys105, Lys147, Lys163, Lys166, Lys245, Lys268, Lys272
  • Modification sites at PhosphoSitePlus

  • See SLC25A6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001627.2  
    ENSEMBL proteins: 
     ENSP00000370808  
    Reactome Protein details: P12236

    SLC25A6 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PAR1: Pseudoautosomal regions / PAR1
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Mitochondrial adenine nucleotide translocator 3
    Mitochondrial adenine nucleotide translocator family

    4 InterPro protein domains:
     IPR002067 Mit_carrier
     IPR023395 Mt_carrier_dom
     IPR018108 Mitochondrial_sb/sol_carrier
     IPR002113 Aden_trnslctor

    Graphical View of Domain Structure for InterPro Entry P12236

    ProtoNet protein and cluster: P12236

    2 Blocks protein domains:
    IPB002067 Mitochondrial carrier protein signature
    IPB002113 Adenine nucleotide translocator 1 signature


    UniProtKB/Swiss-Prot: ADT3_HUMAN, P12236
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 3 Solcar repeats


    SLC25A6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADT3_HUMAN, P12236
    Function: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner
    membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the
    release of mitochondrial products that triggers apoptosis

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005471ATP:ADP antiporter activity NAS2541251
         
    SLC25A6 for ontologies           About GeneDecksing


    Animal Models:
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    2 qRT-PCR Assays for microRNAs that regulate SLC25A6:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADT3_HUMAN, P12236: Mitochondrion inner membrane; Multi-pass membrane protein. Note=The complex formed with
    ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005744mitochondrial inner membrane presequence translocase complex TAS2541251
    GO:0016021integral component of membrane IEA--

    SLC25A6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC25A6 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Electron Transport Chain0.75
    Huntington's disease0.45
    Parkinson's disease0.57
    2Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins
    Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins
    Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization0.00
    3Influenza Viral RNA Transcription and Replication
    Influenza Infection0.80
    Host Interactions with Influenza Factors0.00
    Influenza Virus Induced Apoptosis0.00
    4Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Cellular Apoptosis Pathway0.85
    5Integration of energy metabolism
    Integration of energy metabolism0.75
    Regulation of Insulin Secretion0.75

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SLC25A6
        Mitochondrial Apoptosis
    Cellular Apoptosis Pathway

    1 GeneGo (Thomson Reuters) Pathway for SLC25A6
        Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

    1 BioSystems Pathway for SLC25A6
        Electron Transport Chain


    4 Reactome Pathways for SLC25A6
        Mitochondrial protein import
    Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
    Regulation of insulin secretion
    Influenza Virus Induced Apoptosis


    5 Kegg Pathways  (Kegg details for SLC25A6):
        Calcium signaling pathway
    Parkinson's disease
    Huntington's disease
    Influenza A
    HTLV-I infection


    SLC25A6 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC25A6
    Interactions:

        GeneGlobe Interaction Network for SLC25A6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SLC25A6 (P122362, 3 ENSP000003708084) via UniProtKB, MINT, STRING, and/or I2D (see all 396)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF1A1P681042, 3MINT-6489217 MINT-6488488 MINT-6489355 I2D: score=1 
    TNFRSF1AP194382, 3, ENSP000001627494MINT-49357 I2D: score=2 STRING: ENSP00000162749
    HSPA9P386462, 3, ENSP000002971854MINT-6489217 I2D: score=1 STRING: ENSP00000297185
    IPO4Q8TEX92, 3, ENSP000003464534MINT-6489217 I2D: score=1 STRING: ENSP00000346453
    PLCG1P191742, 3, ENSP000002440074MINT-8112375 I2D: score=1 STRING: ENSP00000244007
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006626protein targeting to mitochondrion TAS--
    GO:0006915apoptotic process IEA--
    GO:0015866ADP transport NAS2541251
    GO:0015867ATP transport NAS2541251

    SLC25A6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC25A6 (ADT3)

    1 DrugBank Compound for SLC25A6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Clodronate-- 10596-23-3targetinhibitor11961144

    3 Novoseek inferred chemical compound relationships for SLC25A6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adp 67.7 4 8486369 (2), 14746803 (1), 16341775 (1)
    atp 55.3 5 8486369 (2), 14746803 (1), 15691486 (1), 16341775 (1)
    cyclosporin a 19.7 1 15063741 (1)



    SLC25A6 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC25A6 gene: 
    NM_001636.3  

    Unigene Cluster for SLC25A6:

    Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
    Hs.350927  [show with all ESTs]
    Unigene Representative Sequence: BM455431
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381401(uc004cpt.3) ENST00000475167 ENST00000484026
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB209822.1 AF076617.1 AF091236.1 AK312336.1 AY007135.1 BC007295.1 BC007850.2 BC008737.2 
    BC008935.2 BC013256.1 BC014775.1 BC031912.1 BC035469.1 CR457400.1 J03592.1 

    Selected DOTS entries (see all 131):

    DT.100714212  DT.100714208  DT.91781059  DT.92037182  DT.455610  DT.100045561  DT.100637571  DT.40115510 
    DT.95263300  DT.91964557  DT.91950160  DT.102838867  DT.91649919  DT.100714176  DT.95263326  DT.100714187 
    DT.120653002  DT.120652842  DT.100714190  DT.100714183  DT.100771650  DT.120652966  DT.121315058  DT.95333723 

    Selected AceView cDNA sequences (see all 2209):

    BQ225730 BQ959944 BF803243 BQ440304 BM969843 CR615726 CB114045 BQ230092 
    BU152568 BF343850 BQ000667 BU145802 BM808312 AA321417 BU930952 BQ060797 
    F01632 BF222017 AW409613 AI357431 BM551587 BM920122 BQ927310 BQ926585 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A6 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b ^ 6a · 6b
    SP1:                    -     -     -     -                                   -     -                     
    SP2:                    -           -     -                                                               
    SP3:                    -           -     -                                                               
    SP4:                    -                 -                                                               
    SP5:                    -                 -                                                               


    ECgene alternative splicing isoforms for SLC25A6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC25A6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGAGACAC
    SLC25A6 Expression
    About this image

    SLC25A6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC25A6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.350927
        Custom PCR Arrays for SLC25A6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC25A6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    rat
    (Rattus norvegicus)
    Mammalia Slc25a61 solute carrier family 25 (mitochondrial carrier; adenine more 78.49(n)
    89.19(a)
      498885  XM_006254935.1  XP_006254997.1 
    chicken
    (Gallus gallus)
    Aves SLC25A61 solute carrier family 25 (mitochondrial carrier; adenine more 79.19(n)
    93.29(a)
      374072  NM_204231.2  NP_989562.2 
    lizard
    (Anolis carolinensis)
    Reptilia SLC25A66
    solute carrier family 25 (mitochondrial carrier; a...
    88(a)
    1 ↔ 1
    GL344275.1(40640-53099)
    zebrafish
    (Danio rerio)
    Actinopterygii slc25a61 solute carrier family 25 (mitochondrial carrier; adenine more 77.07(n)
    91.95(a)
      566370  NM_001128732.1  NP_001122204.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sesB3
    Ant21
    carrier3
    Adenine nucleotide translocase 21
    79(a)
    (best of 2)3
    71.51(n)1
    75.09(a)1
      320081  NM_001272503.11  NP_001259432.11 
    worm
    (Caenorhabditis elegans)
    Secernentea K01H12.23
    ant-1.31
    ADP/ATP carrier protein3
    ant-1.31
    70(a)
    (best of 6)3
    66.55(n)1
    71.87(a)1
      IV(9708187-9709272)3
    1868551  NM_069326.31  NP_501727.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AAC36
    AAC16
    (see all 3)
    Mitochondrial inner membrane ADP/ATP translocator,...
    Mitochondrial inner membrane ADP/ATP translocator,...
    (see all 3)
    52(a)
    50(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    II(415983-416906) YBR085W
    XIII(387315-388244) YMR056C


    ENSEMBL Gene Tree for SLC25A6 (if available)
    TreeFam Gene Tree for SLC25A6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC25A6 gene
    SLC25A312  SLC25A42  SLC25A52  
    8 SIMAP similar genes for SLC25A6 using alignment to 3 protein entries:     ADT3_HUMAN (see all proteins):
    SLC25A5    SLC25A4    SLC25A31    SLC25A23    SLC25A24    SLC25A42
    SLC25A25    SLC25A12

    SLC25A6 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for SLC25A6 (see all 9)
    PGOHUM00000235103 PGOHUM00000244716 PGOHUM00000247463 PGOHUM00000240084 PGOHUM00000243242


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for SLC25A6    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs178512351,2,4
    ----see VAR_0548192 mis40--------

    HapMap Linkage Disequilibrium report for SLC25A6 (1505045 - 1511617 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SLC25A6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666429CNV Deletion23128226
    dgv1357e201CNV Deletion23290073
    esv29996CNV Loss17803354
    esv21933CNV Gain+Loss19812545

    Locus Specific Mutation Databases (LSDB): SLC25A6

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC25A6
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC25A6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300151,403000    OMIM disorders: --

    13 diseases for SLC25A6:    
    About MalaCards
    autosomal dominant progressive external ophthalmoplegia    ophthalmoplegia    influenza    intrahepatic cholangiocarcinoma
    cholangiocarcinoma    huntington's disease    parkinson's disease    hiv-1
    hepatocellular carcinoma    neuroblastoma    prostate cancer    prostatitis
    malaria


    SLC25A6 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for SLC25A6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC25A6 gene, integrated from 10 sources (see all 78):
    (articles sorted by number of sources associating them with SLC25A6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1. (PubMed id 16201016)1, 2 Zamarin D.... Palese P. (PLoS Pathog. 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Mitochondrial membrane permeabilization by HIV-1 Vpr. (PubMed id 16120388)1, 2 Deniaud A.... Kroemer G. (Mitochondrion 2004)
    4. Study of PTPC composition during apoptosis for identification of viral protein target. (PubMed id 15033708)1, 2 Verrier F.... Brenner C. (Ann. N. Y. Acad. Sci. 2003)
    5. DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase. (PubMed id 2541251)1, 2 Cozens A.L.... Walker J.E. (J. Mol. Biol. 1989)
    6. Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver. (PubMed id 2829183)1, 2 Houldsworth J. and Attardi G. (Proc. Natl. Acad. Sci. U.S.A. 1988)
    7. Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured cells. (PubMed id 15063741)1, 9 Zamora M....ViA+as O. (FEBS Lett. 2004)
    8. Mitochondrial adenine nucleotide translocator 3 is regulated by IL-4 and IFN-gamma via STAT-dependent pathways. (PubMed id 14746803)1, 9 Jang J.Y. and Lee C.E. (Cell. Immunol. 2003)
    9. IL-4-induced upregulation of adenine nucleotide translocase 3 and its role in Th cell survival from apoptosis. (PubMed id 16930576)1, 9 Jang J.Y. and Lee C.E. (Cell. Immunol. 2006)
    10. Molecular interactions between mitochondrial membrane proteins and the C-terminal domain of PB1-F2: an in silico approach. (PubMed id 19669810)1, 9 Danishuddin M....Khan A.U. (J Mol Model 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 293 HGNC: 10992 AceView: SLC25A6.1 Ensembl:ENSG00000169100 euGenes: HUgn293
    ECgene: SLC25A6 Kegg: 293 H-InvDB: SLC25A6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SLC25A6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SLC25A6 gene:
    Search GeneIP for patents involving SLC25A6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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