SLC25A53 Gene
protein-coding GIFtS: 35
GCID: GC0XM103344
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|
solute carrier family 25, member 53(Previous name: mitochondrial carrier triple repeat 6 )
(Previous symbol: MCART6)
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Aliases
for SLC25A53 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 25, Member 531 2 | | MCART61 2 3 | | Mitochondrial Carrier Triple Repeat 61 2 | | Mitochondrial Carrier Triple Repeat Protein 62 3 | | Solute Carrier Family 25 Member 532 |
Export aliases for SLC25A53 gene to outside databases |
Summaries
for SLC25A53 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SLC25A53 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SLC25A53
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC25A53
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC25A53 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq22.2 Ensembl cytogenetic band: Xq22.2 HGNC cytogenetic band: Xq22.2SLC25A53 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM103344: view genomic region
(about GC identifiers)
Start:
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103,343,898 bp from pter |
End:
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103,401,708 bp from pter |
Size:
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57,811 bases |
Orientation:
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minus strand |
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Proteins
for SLC25A53 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S2553_HUMAN, Q5H9E4 (See
protein sequence)Recommended Name: Solute carrier family 25 member 53 Size: 307 amino acids; 34481 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B2RTT9Explore the universe of human proteins at neXtProt for SLC25A53: NX_Q5H9E4
SLC25A53 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001012773.2
ENSEMBL proteins: ENSP00000361681
Human Recombinant Protein Products for SLC25A53:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005743 | mitochondrial inner membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
SLC25A53 for ontologies About GeneDecksing
SLC25A53 Antibody Products:
Assay Products for SLC25A53: |
Protein
Domains /
Families
for SLC25A53 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC25A53 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5H9E4ProtoNet protein and cluster: Q5H9E4 UniProtKB/Swiss-Prot: S2553_HUMAN, Q5H9E4Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) familySimilarity: Contains 3 Solcar repeats |
Function
for SLC25A53 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A53 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A53
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for SLC25A53 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A53 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A53 |
|
Pathways & Interactions
for SLC25A53 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC25A53
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006810 | transport |
IEA | -- |
SLC25A53 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC25A53 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC25A53
Search CenterWatch for drugs/clinical trials and news about SLC25A53 / S2553
|
Transcripts
for SLC25A53 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC25A53 gene: NM_001012755.3 Unigene Cluster for SLC25A53: Solute carrier family 25, member 53 Hs.660022 [show with all ESTs]Unigene Representative Sequence: AL8336092 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000357421(uc004elu.3) ENST00000467290
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A53 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A53
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for SLC25A53 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC25A53 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A53 |
Additional cDNA sequence: AL833609.1 BC035919.1 BC140812.1 BC140814.1 3 DOTS entries: DT.95175757 DT.91862833 DT.91816050 14 AceView cDNA sequences: BU158358 BX426139 AL833609 BI856197 AI668646 N78954 W17348 BG391421 AA745794 BC035919 AI734214 AW865890 AV748356 BX456572
GeneLoc Exon Structure
|
Expression
for SLC25A53 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC25A53 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTACAATGT
About this image
See SLC25A53 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC25A53
SOURCE GeneReport for Unigene cluster: Hs.660022
SABiosciences Custom PCR Arrays for SLC25A53
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC25A53
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat SLC25A53 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC25A53 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC25A53 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A53 |
Orthologs
for SLC25A53 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SLC25A53 gene from 3/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
MCART66 |
-- |
52(a) |
1 ↔ 1 |
GL343686.1(70146-71039) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG79436 |
-- |
26(a) |
1 → many |
3R(25872197-25874387) |
worm
(Caenorhabditis elegans) |
Secernentea |
T20D3.56 |
Protein T20D3.5 |
29(a) |
1 → many |
IV(9337046-9338540) |
ENSEMBL Gene Tree for SLC25A53 (if available)
TreeFam Gene Tree for SLC25A53 (if available) |
Paralogs
for SLC25A53 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC25A53 gene
- SLC25A212 SLC25A522 LOC4941412 SLC25A512
2 SIMAP similar genes for SLC25A53 using alignment to 1 protein entry: S2553_HUMAN:SLC25A51 SLC25A52
SLC25A53 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SLC25A53
PGOHUM00000241931
|
Genomic Variants
for SLC25A53 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC25A53 (103343898 - 103401708 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC25A53: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC25A53 |
|
Disorders
/ Diseases
for SLC25A53 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for SLC25A53 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC25A53 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC25A53) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SLC25A53 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC25A53 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC25A53 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC25A53 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC25A53 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC25A53 gene:
Search GeneIP for patents involving SLC25A53
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC25A53 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLC25A53 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC25A53 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC25A53 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLC25A53 | | OriGene 3'-UTR Clone for SLC25A53 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A53 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A53 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC25A53 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC25A53 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC25A53 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC25A53 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC25A53 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC25A53 |
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 | | | SLC25A53 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A53 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for SLC25A53 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A53 |
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