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Aliases for SLC25A52 Gene

Aliases for SLC25A52 Gene

  • Solute Carrier Family 25 Member 52 2 3 5
  • Mitochondrial Carrier Triple Repeat Protein 2 3 4
  • Mitochondrial Carrier Triple Repeat 2 2 3
  • MCART2 3 4
  • Solute Carrier Family 25, Member 52 2

External Ids for SLC25A52 Gene

Previous HGNC Symbols for SLC25A52 Gene

  • MCART2

Previous GeneCards Identifiers for SLC25A52 Gene

  • GC18M029340

Summaries for SLC25A52 Gene

Entrez Gene Summary for SLC25A52 Gene

  • This gene is similar to the mitochondrial carrier triple repeat 1 gene on chromosome 9. The gene is intronless and may be an evolving pseudogene; however, it is transcribed and it contains a full-length coding region so it is currently classified as a protein-coding locus. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC25A52 Gene

SLC25A52 (Solute Carrier Family 25 Member 52) is a Protein Coding gene. An important paralog of this gene is SLC25A51.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A52 Gene

Genomics for SLC25A52 Gene

Regulatory Elements for SLC25A52 Gene

Enhancers for SLC25A52 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F031793 0.2 Ensembl 11.2 -30.6 -30621 0.2 SLC25A52 TRAPPC8 TTR ENSG00000263924
GH18F031565 0.6 ENCODE 10.4 +194.3 194280 1.8 SOX13 ELF3 CEBPG DMAP1 THRB ZNF644 RAD21 RARA TEAD3 CREM TTR B4GALT6 SLC25A52 TRAPPC8 DSG2 DSG2-AS1
GH18F031720 0.2 ENCODE 10.1 +39.7 39696 1.4 MAFK TTR SLC25A52 LRRC37A7P RN7SKP44
GH18F031571 0.7 ENCODE 9.9 +188.0 188013 1.7 GATAD2A HLF ZNF133 CEBPA CEBPB CEBPG ZNF644 B4GALT6 SLC25A52 DSG2-AS1 TTR
GH18F031581 0.6 Ensembl ENCODE 9.5 +179.0 179008 0.7 HLF CEBPG RAD21 NR2F2 YY1 ATF3 CEBPA HNF4G B4GALT6 SLC25A52 TTR DSG2-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SLC25A52 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A52 Gene

31,759,562 bp from pter
31,760,880 bp from pter
1,319 bases
Minus strand

Genomic View for SLC25A52 Gene

Genes around SLC25A52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A52 Gene

Proteins for SLC25A52 Gene

  • Protein details for SLC25A52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 25 member 52
    Protein Accession:

    Protein attributes for SLC25A52 Gene

    297 amino acids
    Molecular mass:
    33721 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC25A52 Gene

Post-translational modifications for SLC25A52 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A52 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A52 Gene

Domains & Families for SLC25A52 Gene

Gene Families for SLC25A52 Gene

Protein Domains for SLC25A52 Gene

Suggested Antigen Peptide Sequences for SLC25A52 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



S2552_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A52: view

Function for SLC25A52 Gene

genes like me logo Genes that share phenotypes with SLC25A52: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC25A52 Gene

Localization for SLC25A52 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A52 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC25A52 Gene COMPARTMENTS Subcellular localization image for SLC25A52 gene
Compartment Confidence
mitochondrion 4
peroxisome 3
cytosol 2
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC25A52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC25A52: view

Pathways & Interactions for SLC25A52 Gene

SuperPathways for SLC25A52 Gene

No Data Available

Interacting Proteins for SLC25A52 Gene

Selected Interacting proteins: Q3SY17-S2552_HUMAN for SLC25A52 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SLC25A52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with SLC25A52: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A52 Gene

Transcripts for SLC25A52 Gene

mRNA/cDNA for SLC25A52 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC25A52 Gene

Solute carrier family 25, member 52:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A52 Gene

No ASD Table

Relevant External Links for SLC25A52 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC25A52 Gene

mRNA expression in normal human tissues for SLC25A52 Gene

mRNA differential expression in normal tissues according to GTEx for SLC25A52 Gene

This gene is overexpressed in Testis (x34.4).

Protein differential expression in normal tissues from HIPED for SLC25A52 Gene

This gene is overexpressed in Fetal Brain (17.0), Heart (12.7), Frontal cortex (11.6), Placenta (10.2), CD4 Tcells (9.5), and CD8 Tcells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC25A52 Gene

Protein tissue co-expression partners for SLC25A52 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC25A52 Gene:


SOURCE GeneReport for Unigene cluster for SLC25A52 Gene:

genes like me logo Genes that share expression patterns with SLC25A52: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SLC25A52 Gene

Orthologs for SLC25A52 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC25A52 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC25A52 34 35
  • 98.7 (n)
(Canis familiaris)
Mammalia -- 35
  • 93 (a)
(Bos Taurus)
Mammalia MCART1 35
  • 91 (a)
(Mus musculus)
Mammalia Slc25a51 35
  • 85 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 76 (a)
(Gallus gallus)
Aves -- 35
  • 68 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 72 (a)
(Danio rerio)
Actinopterygii zgc:73228 34 35
  • 62.53 (n)
BX088718.1 35
  • 54 (a)
CU638740.1 35
  • 54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7943 35
  • 39 (a)
(Caenorhabditis elegans)
Secernentea T20D3.5 35
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
Species where no ortholog for SLC25A52 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC25A52 Gene

Gene Tree for SLC25A52 (if available)
Gene Tree for SLC25A52 (if available)

Paralogs for SLC25A52 Gene

Paralogs for SLC25A52 Gene

(2) SIMAP similar genes for SLC25A52 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC25A52: view

Variants for SLC25A52 Gene

Sequence variations from dbSNP and Humsavar for SLC25A52 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs10853414 -- 31,762,575(+) CTCCT(C/T)AGTCC upstream-variant-2KB
rs112501723 -- 31,760,700(+) TTAAC(C/T)TGTGA utr-variant-5-prime
rs112668410 -- 31,760,677(+) ATCTT(C/T)CTCAT reference, synonymous-codon
rs113055536 -- 31,761,725(+) AACAG(C/T)GGAAG upstream-variant-2KB
rs113697942 -- 31,759,542(+) AAAAA(A/G)AAAGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SLC25A52 Gene

Variant ID Type Subtype PubMed ID
esv3893086 CNV gain 25118596
nsv1057229 CNV gain 25217958
nsv960273 CNV duplication 23825009

Variation tolerance for SLC25A52 Gene

Residual Variation Intolerance Score: 94.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 52.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A52 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A52 Gene

Disorders for SLC25A52 Gene

Relevant External Links for SLC25A52

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC25A52 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A52 Gene

Publications for SLC25A52 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F. (Mol. Aspects Med. 2013) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C. … Lander E.S. (Nature 2005) 4 64

Products for SLC25A52 Gene

Sources for SLC25A52 Gene

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