Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC25A51 Gene

Aliases for SLC25A51 Gene

  • Solute Carrier Family 25 Member 51 2 3 5
  • Mitochondrial Carrier Triple Repeat Protein 1 3 4
  • Mitochondrial Carrier Triple Repeat 1 2 3
  • MCART1 3 4
  • Solute Carrier Family 25, Member 51 2
  • CG7943 3

External Ids for SLC25A51 Gene

Previous HGNC Symbols for SLC25A51 Gene

  • MCART1

Summaries for SLC25A51 Gene

GeneCards Summary for SLC25A51 Gene

SLC25A51 (Solute Carrier Family 25 Member 51) is a Protein Coding gene. An important paralog of this gene is SLC25A52.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A51 Gene

Genomics for SLC25A51 Gene

Regulatory Elements for SLC25A51 Gene

Enhancers for SLC25A51 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G038057 2 FANTOM5 Ensembl ENCODE dbSUPER 16.9 -159.6 -159638 13.7 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF263 SP3 NFYC TBX21 MEF2D SLC25A51 EXOSC3 ZBTB5 RNU7-124P SHB RPL21P83 TMX2P1 GC09P038069 GC09M038063
GH09G037936 1.8 FANTOM5 Ensembl ENCODE dbSUPER 15.8 -34.0 -33966 3.9 HDGF PKNOX1 ATF1 CREB3L1 ARNT SIN3A FEZF1 TCF12 GATA2 FOS TMX2P1 SHB SLC25A51 ENSG00000255872 RNU7-124P GC09M038063
GH09G038021 1.5 Ensembl ENCODE dbSUPER 16.7 -121.2 -121168 7.5 PKNOX1 MLX ARID4B SIN3A DMAP1 FEZF1 ZNF48 YY1 ZNF121 GLIS2 SHB TMX2P1 SLC25A51 ENSG00000255872 RNU7-124P GC09P038069 GC09M038063
GH09G038379 2 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -482.9 -482873 15.1 HDGF FOXA2 CREB3L1 MLX ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ALDH1B1 IGFBPL1 SLC25A51 LOC105376040
GH09G037949 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -48.2 -48186 6.3 HDGF FOXA2 PKNOX1 MLX ARID4B SIN3A FOS KLF13 ZNF263 NFYC SHB SLC25A51 ENSG00000255872 ALDH1B1 EXOSC3 RNU7-124P GC09M038063
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A51 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A51 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000234907 453 1801 CREB3L1 MLX AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for SLC25A51 Gene

Chromosome:
9
Start:
37,877,575 bp from pter
End:
37,904,353 bp from pter
Size:
26,779 bases
Orientation:
Minus strand

Genomic View for SLC25A51 Gene

Genes around SLC25A51 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A51 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A51 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A51 Gene

Proteins for SLC25A51 Gene

  • Protein details for SLC25A51 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1U9-S2551_HUMAN
    Recommended name:
    Solute carrier family 25 member 51
    Protein Accession:
    Q9H1U9

    Protein attributes for SLC25A51 Gene

    Size:
    297 amino acids
    Molecular mass:
    33672 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC25A51 Gene

Post-translational modifications for SLC25A51 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A51 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A51 Gene

Domains & Families for SLC25A51 Gene

Gene Families for SLC25A51 Gene

Protein Domains for SLC25A51 Gene

Suggested Antigen Peptide Sequences for SLC25A51 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H1U9

UniProtKB/Swiss-Prot:

S2551_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A51: view

Function for SLC25A51 Gene

Gene Ontology (GO) - Molecular Function for SLC25A51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC25A51: view
genes like me logo Genes that share phenotypes with SLC25A51: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A51

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A51 Gene

Localization for SLC25A51 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A51 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A51 gene
Compartment Confidence
mitochondrion 4
peroxisome 3
cytosol 2
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLC25A51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IBA,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IEA --
genes like me logo Genes that share ontologies with SLC25A51: view

Pathways & Interactions for SLC25A51 Gene

SuperPathways for SLC25A51 Gene

No Data Available

Interacting Proteins for SLC25A51 Gene

Gene Ontology (GO) - Biological Process for SLC25A51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006839 mitochondrial transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A51: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A51 Gene

Drugs & Compounds for SLC25A51 Gene

No Compound Related Data Available

Transcripts for SLC25A51 Gene

mRNA/cDNA for SLC25A51 Gene

Unigene Clusters for SLC25A51 Gene

Solute carrier family 25, member 51:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A51 Gene

No ASD Table

Relevant External Links for SLC25A51 Gene

GeneLoc Exon Structure for
SLC25A51
ECgene alternative splicing isoforms for
SLC25A51

Expression for SLC25A51 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A51 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC25A51 Gene

This gene is overexpressed in Frontal cortex (21.8), Heart (21.6), Blymphocyte (14.0), and Retina (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC25A51 Gene



Protein tissue co-expression partners for SLC25A51 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC25A51 Gene:

SLC25A51

SOURCE GeneReport for Unigene cluster for SLC25A51 Gene:

Hs.634120

Evidence on tissue expression from TISSUES for SLC25A51 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SLC25A51: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A51 Gene

Orthologs for SLC25A51 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC25A51 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A51 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 94 (a)
OneToMany
SLC25A51 34
  • 91.02 (n)
cow
(Bos Taurus)
Mammalia MCART1 35 34
  • 92.03 (n)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mcart1 34
  • 81.82 (n)
mouse
(Mus musculus)
Mammalia Slc25a51 34 16 35
  • 80.7 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves SLC25A51 34
  • 76.16 (n)
-- 35
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 74 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a51 34
  • 70.59 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC556422 34
  • 62.14 (n)
zgc:73228 35
  • 57 (a)
ManyToMany
BX088718.1 35
  • 55 (a)
ManyToMany
CU638740.1 35
  • 55 (a)
ManyToMany
zgc73228 34
fruit fly
(Drosophila melanogaster)
Insecta CG7943 34 35
  • 49.88 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002280 34
  • 49.12 (n)
worm
(Caenorhabditis elegans)
Secernentea T20D3.5 34 35
  • 51.85 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 51 (a)
OneToMany
Species where no ortholog for SLC25A51 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A51 Gene

ENSEMBL:
Gene Tree for SLC25A51 (if available)
TreeFam:
Gene Tree for SLC25A51 (if available)

Paralogs for SLC25A51 Gene

Paralogs for SLC25A51 Gene

(2) SIMAP similar genes for SLC25A51 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SLC25A51 Gene

genes like me logo Genes that share paralogs with SLC25A51: view

Variants for SLC25A51 Gene

Sequence variations from dbSNP and Humsavar for SLC25A51 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs780199922 A breast cancer sample 37,887,937(+) GAGTC(A/G)TTGCG intron-variant, reference, missense
rs1000030454 -- 37,880,334(+) TGACA(A/G)TATGA nc-transcript-variant
rs1000057257 -- 37,906,122(+) TCTTG(G/T)TTCCC upstream-variant-2KB
rs1000092181 -- 37,880,568(+) CAACA(C/T)GGAGA nc-transcript-variant
rs1000397581 -- 37,899,131(+) AAAGT(A/G)CCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A51 Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259
nsv469814 CNV gain 16826518
nsv968615 CNV duplication 23825009
nsv968616 CNV duplication 23825009
nsv972315 CNV duplication 23825009

Variation tolerance for SLC25A51 Gene

Residual Variation Intolerance Score: 45.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A51 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A51

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A51 Gene

Disorders for SLC25A51 Gene

Relevant External Links for SLC25A51

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A51

No disorders were found for SLC25A51 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A51 Gene

Publications for SLC25A51 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for SLC25A51 Gene

Sources for SLC25A51 Gene

Content
Loading form....