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Aliases for SLC25A51 Gene

Aliases for SLC25A51 Gene

  • Solute Carrier Family 25 Member 51 2 3 5
  • Mitochondrial Carrier Triple Repeat Protein 1 3 4
  • Mitochondrial Carrier Triple Repeat 1 2 3
  • MCART1 3 4
  • Solute Carrier Family 25, Member 51 2
  • CG7943 3

External Ids for SLC25A51 Gene

Previous HGNC Symbols for SLC25A51 Gene

  • MCART1

Summaries for SLC25A51 Gene

GeneCards Summary for SLC25A51 Gene

SLC25A51 (Solute Carrier Family 25 Member 51) is a Protein Coding gene. An important paralog of this gene is SLC25A52.

Additional gene information for SLC25A51 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A51 Gene

Genomics for SLC25A51 Gene

Regulatory Elements for SLC25A51 Gene

Enhancers for SLC25A51 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H038057 2 FANTOM5 Ensembl ENCODE dbSUPER 16.9 -159.6 -159638 13 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 SP3 SLC25A51 PAICSP1 RNU7-124P SHB TMX2P1 GC09P038069 GC09M038077
GH09H037936 1.8 FANTOM5 Ensembl ENCODE dbSUPER 15.8 -34.0 -33966 3 HDAC1 TBP HDGF PKNOX1 ATF1 TBL1XR1 ARNT FEZF1 TCF12 GATA2 TMX2P1 SHB SLC25A51 ENSG00000255872 RNU7-124P GC09M038077
GH09H038021 1.5 Ensembl ENCODE dbSUPER 16.7 -121.2 -121168 7 FOXA2 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF121 GLIS2 EXOSC3 SHB TMX2P1 DCAF10 SLC25A51 ZCCHC7 ZBTB5 ENSG00000255872 RNU7-124P GC09P038069
GH09H038379 2 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -482.9 -482873 15 HDGF FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ALDH1B1 IGFBPL1 SLC25A51 LOC105376040
GH09H037949 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -48.2 -48186 6 HDGF PKNOX1 ATF1 FOXA2 MLX ARID4B SIN3A FOS ATF7 RUNX3 SHB ENSG00000255872 SLC25A51 ALDH1B1 EXOSC3 RNU7-124P GC09M038077
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A51 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A51 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000234907 453 1801 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for SLC25A51 Gene

Chromosome:
9
Start:
37,877,575 bp from pter
End:
37,904,353 bp from pter
Size:
26,779 bases
Orientation:
Minus strand

Genomic View for SLC25A51 Gene

Genes around SLC25A51 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A51 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A51 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A51 Gene

Proteins for SLC25A51 Gene

  • Protein details for SLC25A51 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1U9-S2551_HUMAN
    Recommended name:
    Solute carrier family 25 member 51
    Protein Accession:
    Q9H1U9

    Protein attributes for SLC25A51 Gene

    Size:
    297 amino acids
    Molecular mass:
    33672 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC25A51 Gene

Post-translational modifications for SLC25A51 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A51 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A51 Gene

Domains & Families for SLC25A51 Gene

Gene Families for SLC25A51 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC25A51 Gene

Suggested Antigen Peptide Sequences for SLC25A51 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H1U9

UniProtKB/Swiss-Prot:

S2551_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A51: view

Function for SLC25A51 Gene

Phenotypes From GWAS Catalog for SLC25A51 Gene

Gene Ontology (GO) - Molecular Function for SLC25A51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC25A51: view
genes like me logo Genes that share phenotypes with SLC25A51: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A51

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC25A51
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A51 Gene

Localization for SLC25A51 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A51 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A51 gene
Compartment Confidence
mitochondrion 4
peroxisome 3
cytosol 2
nucleus 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC25A51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with SLC25A51: view

Pathways & Interactions for SLC25A51 Gene

SuperPathways for SLC25A51 Gene

No Data Available

Interacting Proteins for SLC25A51 Gene

Gene Ontology (GO) - Biological Process for SLC25A51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006839 mitochondrial transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A51: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A51 Gene

Drugs & Compounds for SLC25A51 Gene

No Compound Related Data Available

Transcripts for SLC25A51 Gene

mRNA/cDNA for SLC25A51 Gene

Unigene Clusters for SLC25A51 Gene

Solute carrier family 25, member 51:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC25A51
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A51 Gene

No ASD Table

Relevant External Links for SLC25A51 Gene

GeneLoc Exon Structure for
SLC25A51
ECgene alternative splicing isoforms for
SLC25A51

Expression for SLC25A51 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A51 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC25A51 Gene

This gene is overexpressed in Frontal cortex (21.8), Heart (21.6), Blymphocyte (14.0), and Retina (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC25A51 Gene



Protein tissue co-expression partners for SLC25A51 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC25A51 Gene:

SLC25A51

SOURCE GeneReport for Unigene cluster for SLC25A51 Gene:

Hs.634120

Evidence on tissue expression from TISSUES for SLC25A51 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SLC25A51: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A51 Gene

Orthologs for SLC25A51 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC25A51 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A51 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 94 (a)
OneToMany
SLC25A51 33
  • 91.02 (n)
cow
(Bos Taurus)
Mammalia MCART1 33 34
  • 92.03 (n)
rat
(Rattus norvegicus)
Mammalia LOC100909697 33
  • 81.82 (n)
mouse
(Mus musculus)
Mammalia Slc25a51 33 16 34
  • 80.7 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves SLC25A51 33
  • 76.16 (n)
-- 34
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 74 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a51 33
  • 70.59 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC556422 33
  • 62.14 (n)
zgc:73228 34
  • 57 (a)
ManyToMany
BX088718.1 34
  • 55 (a)
ManyToMany
CU638740.1 34
  • 55 (a)
ManyToMany
zgc73228 33
fruit fly
(Drosophila melanogaster)
Insecta CG7943 33 34
  • 49.88 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002280 33
  • 49.12 (n)
worm
(Caenorhabditis elegans)
Secernentea T20D3.5 33 34
  • 51.85 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 51 (a)
OneToMany
Species where no ortholog for SLC25A51 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A51 Gene

ENSEMBL:
Gene Tree for SLC25A51 (if available)
TreeFam:
Gene Tree for SLC25A51 (if available)

Paralogs for SLC25A51 Gene

Paralogs for SLC25A51 Gene

(2) SIMAP similar genes for SLC25A51 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SLC25A51 Gene

genes like me logo Genes that share paralogs with SLC25A51: view

Variants for SLC25A51 Gene

Sequence variations from dbSNP and Humsavar for SLC25A51 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs780199922 A breast cancer sample 37,887,937(+) GAGTC(A/G)TTGCG intron-variant, reference, missense
rs1000030454 -- 37,880,334(+) TGACA(A/G)TATGA nc-transcript-variant
rs1000057257 -- 37,906,122(+) TCTTG(G/T)TTCCC upstream-variant-2KB
rs1000092181 -- 37,880,568(+) CAACA(C/T)GGAGA nc-transcript-variant
rs1000397581 -- 37,899,131(+) AAAGT(A/G)CCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A51 Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259
nsv469814 CNV gain 16826518
nsv968615 CNV duplication 23825009
nsv968616 CNV duplication 23825009
nsv972315 CNV duplication 23825009

Variation tolerance for SLC25A51 Gene

Residual Variation Intolerance Score: 45.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A51 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A51

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A51 Gene

Disorders for SLC25A51 Gene

Relevant External Links for SLC25A51

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A51

No disorders were found for SLC25A51 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A51 Gene

Publications for SLC25A51 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 60

Products for SLC25A51 Gene

Sources for SLC25A51 Gene

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