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Aliases for SLC25A5 Gene

Aliases for SLC25A5 Gene

  • Solute Carrier Family 25 Member 5 2 3 4 5
  • Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 5 2 3
  • ADP,ATP Carrier Protein, Fibroblast Isoform 3 4
  • ANT2 3 4
  • Adenine Nucleotide Translocator 2 (Fibroblast) 3
  • Adenine Nucleotide Translocator 2 4
  • ADP,ATP Carrier Protein 2 4
  • ADP/ATP Translocase 2 3
  • ANT 2 4
  • AAC2 3
  • 2F1 3
  • T2 3
  • T3 3

External Ids for SLC25A5 Gene

Previous HGNC Symbols for SLC25A5 Gene

  • ANT2

Previous GeneCards Identifiers for SLC25A5 Gene

  • GC0XP113420
  • GC0XP115588
  • GC0XP116577
  • GC0XP117356
  • GC0XP118384
  • GC0XP118486
  • GC0XP118602
  • GC0XP108095

Summaries for SLC25A5 Gene

Entrez Gene Summary for SLC25A5 Gene

  • This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013]

GeneCards Summary for SLC25A5 Gene

SLC25A5 (Solute Carrier Family 25 Member 5) is a Protein Coding gene. Diseases associated with SLC25A5 include Non-Syndromic Intellectual Disability and Male Reproductive Organ Benign Neoplasm. Among its related pathways are Calcium signaling pathway and Metabolism. GO annotations related to this gene include poly(A) RNA binding and adenine transmembrane transporter activity. An important paralog of this gene is SLC25A6.

UniProtKB/Swiss-Prot for SLC25A5 Gene

  • Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

Additional gene information for SLC25A5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A5 Gene

Genomics for SLC25A5 Gene

Regulatory Elements for SLC25A5 Gene

Enhancers for SLC25A5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH119493 1.3 Ensembl ENCODE dbSUPER 20.1 +27.1 27099 4.3 SOX13 TFAP4 FOXA2 SAP130 MAX DMAP1 ZNF384 ZNF644 RARA TEAD3 SLC25A43 CXorf56 SLC25A5 SLC25A5-AS1 ENSG00000226661 GC0XM119476 GC0XM119539
GH0XH119512 1.2 Ensembl ENCODE dbSUPER 12.7 +44.1 44093 0.6 CTCF ZNF654 RB1 ARID4B ZNF384 REST RAD21 ZNF121 BCL6B SMC3 CXorf56 SLC25A43 SLC25A5-AS1 SLC25A5 RNU1-67P ENSG00000237903 ENSG00000226661 GC0XM119539 GC0XM119476
GH0XH119466 1.3 ENCODE dbSUPER 7.9 +0.8 809 4.6 PKNOX1 ATF1 ZNF493 ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2 ELK1 SLC25A43 CXorf56 NKAPP1 UPF3B ENSG00000237903 RNU1-67P SLC25A5-AS1 SLC25A5 PIR58034
GH0XH119481 1.4 Ensembl ENCODE dbSUPER 7.2 +13.9 13929 2.2 PKNOX1 RB1 SIN3A KLF17 FEZF1 ZNF2 RAD21 YY1 ZNF143 ATF7 CXorf56 SLC25A5 GC0XM119476 GC0XM119539
GH0XH119500 1.4 Ensembl ENCODE dbSUPER 6.4 +35.2 35187 6.3 ELF3 PKNOX1 FOXA2 SIN3A DMAP1 RAD21 YY1 ZNF121 CREM MIXL1 CXorf56 SLC25A43 SLC25A5 GC0XM119476 GC0XM119539
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A5 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000248334 400 2001 PKNOX1 ATF1 ZNF493 ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2 ELK1

Genomic Locations for SLC25A5 Gene

Genomic Locations for SLC25A5 Gene
2,997 bases
Plus strand

Genomic View for SLC25A5 Gene

Genes around SLC25A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A5 Gene

Proteins for SLC25A5 Gene

  • Protein details for SLC25A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP/ATP translocase 2
    Protein Accession:
    Secondary Accessions:
    • B2RCV1
    • O43350

    Protein attributes for SLC25A5 Gene

    298 amino acids
    Molecular mass:
    32852 Da
    Quaternary structure:
    • Homodimer. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with HIV-1 Vpr.
    • The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).

neXtProt entry for SLC25A5 Gene

Post-translational modifications for SLC25A5 Gene

  • Ubiquitination at Lys43, isoforms=105, Lys166, and Lys245
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC25A5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A5 Gene

Domains & Families for SLC25A5 Gene

Gene Families for SLC25A5 Gene

Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Plasma proteins
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for SLC25A5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A5: view

Function for SLC25A5 Gene

Molecular function for SLC25A5 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

Gene Ontology (GO) - Molecular Function for SLC25A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005215 transporter activity IEA --
GO:0005471 ATP:ADP antiporter activity IBA --
GO:0005515 protein binding IPI 17715127
GO:0015207 adenine transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLC25A5: view
genes like me logo Genes that share phenotypes with SLC25A5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A5 Gene

Localization for SLC25A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A5 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A5 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
mitochondrion 5
nucleus 5
plasma membrane 4
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC25A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA,IEA 20833797
GO:0005743 mitochondrial inner membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2168878
GO:0016020 membrane IDA,IEA 19946888
genes like me logo Genes that share ontologies with SLC25A5: view

Pathways & Interactions for SLC25A5 Gene

genes like me logo Genes that share pathways with SLC25A5: view

Pathways by source for SLC25A5 Gene

1 Cell Signaling Technology pathway for SLC25A5 Gene
1 BioSystems pathway for SLC25A5 Gene

Gene Ontology (GO) - Biological Process for SLC25A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 2168878
GO:0007059 chromosome segregation IEA --
GO:0008284 positive regulation of cell proliferation IMP 19154410
GO:0015853 adenine transport IEA --
GO:0015866 ADP transport IEA --
genes like me logo Genes that share ontologies with SLC25A5: view

No data available for SIGNOR curated interactions for SLC25A5 Gene

Drugs & Compounds for SLC25A5 Gene

(6) Drugs for SLC25A5 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clodronate Approved, Investigational, Vet_approved Pharma inhibitor, Target 10
Atractyloside Dipotassium Salt Pharma ANT inhibitor 0

(1) Additional Compounds for SLC25A5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for SLC25A5 Gene

Compound Action Cas Number
Atractyloside Dipotassium Salt ANT inhibitor 102130-43-8
genes like me logo Genes that share compounds with SLC25A5: view

Drug Products

Transcripts for SLC25A5 Gene

Unigene Clusters for SLC25A5 Gene

Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A5 Gene

No ASD Table

Relevant External Links for SLC25A5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC25A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC25A5 Gene

This gene is overexpressed in Nasal epithelium (23.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC25A5 Gene

Protein tissue co-expression partners for SLC25A5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC25A5 Gene:


SOURCE GeneReport for Unigene cluster for SLC25A5 Gene:


Evidence on tissue expression from TISSUES for SLC25A5 Gene

  • Nervous system(4.9)
  • Eye(4.6)
  • Liver(4.6)
  • Skin(4.3)
  • Blood(4.2)
  • Lung(4.1)
  • Pancreas(3.7)
  • Intestine(3.6)
  • Kidney(3.6)
  • Muscle(2.7)
  • Stomach(2.6)
  • Heart(2.5)
  • Thyroid gland(2.4)
  • Lymph node(2.2)
  • Bone marrow(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with SLC25A5: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A5 Gene

Orthologs for SLC25A5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC25A5 34
  • 100 (a)
(Canis familiaris)
Mammalia SLC25A5 33 34
  • 94.18 (n)
(Bos Taurus)
Mammalia SLC25A5 33 34
  • 93.18 (n)
(Rattus norvegicus)
Mammalia Slc25a5 33
  • 93.06 (n)
(Mus musculus)
Mammalia Slc25a5 33 16 34
  • 92.62 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 91 (a)
-- 34
  • 91 (a)
-- 34
  • 91 (a)
-- 34
  • 91 (a)
-- 34
  • 78 (a)
-- 34
  • 70 (a)
(Gallus gallus)
Aves SLC25A6 34
  • 88 (a)
SLC25A5 33
  • 81.32 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 91 (a)
-- 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75700 33
  • 80.81 (n)
(Danio rerio)
Actinopterygii SLC25A5 (1 of 2) 34
  • 84 (a)
slc25a5 33 34
  • 81.98 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta sesB 35 34
  • 81 (a)
Ant2 35 34
  • 74 (a)
(Caenorhabditis elegans)
Secernentea K01H12.2 35
  • 71 (a)
T01B11.4 35
  • 71 (a)
ant-1.1 34
  • 68 (a)
W02D3.6 35
  • 67 (a)
ant-1.3 34
  • 67 (a)
C47E12.2 35 34
  • 51 (a)
F25B4.7 35 34
  • 47 (a)
R07E3.4 35
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAC3 34
  • 52 (a)
AAC1 34
  • 50 (a)
PET9 34
  • 50 (a)
(Oryza sativa)
Liliopsida Os.23386 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2354 34
  • 53 (a)
Species where no ortholog for SLC25A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A5 Gene

Gene Tree for SLC25A5 (if available)
Gene Tree for SLC25A5 (if available)

Paralogs for SLC25A5 Gene

Paralogs for SLC25A5 Gene

(5) SIMAP similar genes for SLC25A5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC25A5: view

Variants for SLC25A5 Gene

Sequence variations from dbSNP and Humsavar for SLC25A5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs115513989 Uncertain significance 119,470,436(+) TGTCA(C/G)TGCTG upstream-variant-2KB, reference, missense
rs73213195 Benign 119,471,038(+) ATGAT(G/T)AAATC upstream-variant-2KB, reference, stop-gained
rs77294853 Benign 119,471,054(+) GTACA(C/T)ATAAG upstream-variant-2KB, reference, missense
rs80323990 Benign 119,471,049(+) AAGAA(C/G)TACAC upstream-variant-2KB, reference, missense
rs1000213813 -- 119,466,475(+) GAGAG(-/A)AAAAA nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC25A5 Gene

Variant ID Type Subtype PubMed ID
esv2740427 CNV deletion 23290073
esv2740429 CNV deletion 23290073

Variation tolerance for SLC25A5 Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A5 Gene

Disorders for SLC25A5 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SLC25A5 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
non-syndromic intellectual disability
male reproductive organ benign neoplasm
oxyphilic adenoma
  • follicular adenoma, oxyphilic cell
prostatic adenoma
  • adenoma - prostate
dilated cardiomyopathy
  • congestive cardiomyopathy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC25A5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLC25A5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC25A5 Gene

Publications for SLC25A5 Gene

  1. Ordered shotgun sequencing of a 135 kb Xq25 YAC containing ANT2 and four possible genes, including three confirmed by EST matches. (PMID: 8918809) Chen CN … Chen E (Nucleic acids research 1996) 3 4 22 60
  2. The human fibroblast adenine nucleotide translocator gene. Molecular cloning and sequence. (PMID: 2168878) Ku DH … Wurzel J (The Journal of biological chemistry 1990) 2 3 4 60
  3. Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver. (PMID: 2829183) Houldsworth J … Attardi G (Proceedings of the National Academy of Sciences of the United States of America 1988) 2 3 4 60
  4. MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation. (PMID: 20797633) Ito S … Tanaka K (Molecular cell 2010) 3 4 60
  5. Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis. (PMID: 19154410) Kashiwaya K … Nakagawa H (Cancer science 2009) 3 22 60

Products for SLC25A5 Gene

Sources for SLC25A5 Gene

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