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Aliases for SLC25A5 Gene

Aliases for SLC25A5 Gene

  • Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 5 2 3
  • ANT2 3 4 6
  • ADP,ATP Carrier Protein, Fibroblast Isoform 3 4
  • Solute Carrier Family 25 Member 5 3 4
  • ADP,ATP Carrier Protein 2 3 4
  • ANT 2 3 4
  • T3 3 6
  • Adenine Nucleotide Translocator 2 (Fibroblast) 3
  • Adenine Nucleotide Translocator 2 4
  • ADP/ATP Carrier Protein 3
  • ADP/ATP Translocase 2 3
  • AAC2 3
  • 2F1 3
  • T2 3

External Ids for SLC25A5 Gene

Previous Symbols for SLC25A5 Gene

  • ANT2

Summaries for SLC25A5 Gene

Entrez Gene Summary for SLC25A5 Gene

  • This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013]

GeneCards Summary for SLC25A5 Gene

SLC25A5 (Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 5) is a Protein Coding gene. Diseases associated with SLC25A5 include non-syndromic intellectual disability and syndromic intellectual disability. Among its related pathways are Disease and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include adenine transmembrane transporter activity. An important paralog of this gene is SLC25A4.

UniProtKB/Swiss-Prot for SLC25A5 Gene

  • Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A5 Gene

Genomics for SLC25A5 Gene

Genomic Location for SLC25A5 Gene

Start:
119,468,400 bp from pter
End:
119,471,396 bp from pter
Size:
2,997 bases
Orientation:
Plus strand

Genomic View for SLC25A5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC25A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A5 Gene

Regulatory Elements for SLC25A5 Gene

Proteins for SLC25A5 Gene

  • Protein details for SLC25A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05141-ADT2_HUMAN
    Recommended name:
    ADP/ATP translocase 2
    Protein Accession:
    P05141
    Secondary Accessions:
    • B2RCV1
    • O43350

    Protein attributes for SLC25A5 Gene

    Size:
    298 amino acids
    Molecular mass:
    32852 Da
    Quaternary structure:
    • Homodimer. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with HIV-1 Vpr.
    Miscellaneous:
    • The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).

neXtProt entry for SLC25A5 Gene

Proteomics data for SLC25A5 Gene at MOPED

Post-translational modifications for SLC25A5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys43, Lys63, Lys105, Lys147, Lys163, Lys166, Lys245, Lys268, and Lys272

Other Protein References for SLC25A5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A5 Gene

Domains for SLC25A5 Gene

Suggested Antigen Peptide Sequences for SLC25A5 Gene

Graphical View of Domain Structure for InterPro Entry

P05141

UniProtKB/Swiss-Prot:

ADT2_HUMAN
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.:
    • P05141
Similarity:
  • Contains 3 Solcar repeats.:
    • P05141
genes like me logo Genes that share domains with SLC25A5: view

Function for SLC25A5 Gene

Molecular function for SLC25A5 Gene

UniProtKB/Swiss-Prot Function: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

Gene Ontology (GO) - Molecular Function for SLC25A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17715127
GO:0015207 adenine transmembrane transporter activity TAS 2168878
GO:0031625 ubiquitin protein ligase binding IPI 19725078
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SLC25A5: view

Phenotypes for SLC25A5 Gene

MGI mutant phenotypes for SLC25A5:
inferred from 1 alleles
GenomeRNAi human phenotypes for SLC25A5:
genes like me logo Genes that share phenotypes with SLC25A5: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC25A5 Gene

Localization for SLC25A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A5 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A5 Gene COMPARTMENTS Subcellular localization image for SLC25A5 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 5
plasma membrane 4
cytosol 2
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC25A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA 20833797
GO:0005743 mitochondrial inner membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2168878
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with SLC25A5: view

Pathways for SLC25A5 Gene

genes like me logo Genes that share pathways with SLC25A5: view

Pathways by source for SLC25A5 Gene

1 GeneGo (Thomson Reuters) pathway for SLC25A5 Gene
2 Qiagen pathways for SLC25A5 Gene
1 Cell Signaling Technology pathway for SLC25A5 Gene

Gene Ontology (GO) - Biological Process for SLC25A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0006810 transport TAS 2168878
GO:0007059 chromosome segregation IEA --
GO:0008284 positive regulation of cell proliferation IMP 19154410
GO:0015853 adenine transport TAS 2168878
genes like me logo Genes that share ontologies with SLC25A5: view

Compounds for SLC25A5 Gene

(1) Drugbank Compounds for SLC25A5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Clodronate
10596-23-3 target inhibitor

(5) Novoseek inferred chemical compound relationships for SLC25A5 Gene

Compound -log(P) Hits PubMed IDs
adp 66.2 5
atp 55.7 10
chloramphenicol 22 1
thymidine 7.8 3
oxygen 0 2
genes like me logo Genes that share compounds with SLC25A5: view

Transcripts for SLC25A5 Gene

mRNA/cDNA for SLC25A5 Gene

Unigene Clusters for SLC25A5 Gene

Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A5 Gene

No ASD Table

Relevant External Links for SLC25A5 Gene

GeneLoc Exon Structure for
SLC25A5
ECgene alternative splicing isoforms for
SLC25A5

Expression for SLC25A5 Gene

mRNA expression in normal human tissues for SLC25A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A5 Gene

SOURCE GeneReport for Unigene cluster for SLC25A5 Gene Hs.632282

genes like me logo Genes that share expressions with SLC25A5: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC25A5 Gene

Orthologs for SLC25A5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC25A5 35
  • 93.18 (n)
  • 97.99 (a)
SLC25A5 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A5 35
  • 94.18 (n)
  • 97.32 (a)
SLC25A5 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a5 35
  • 92.62 (n)
  • 98.32 (a)
Slc25a5 16
Slc25a5 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slc25a5 35
  • 93.06 (n)
  • 98.66 (a)
chicken
(Gallus gallus)
Aves SLC25A5 35
  • 81.32 (n)
  • 94.61 (a)
SLC25A6 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 91 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75700 35
  • 80.81 (n)
  • 91.92 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
slc25a5 35
  • 81.98 (n)
  • 92.91 (a)
slc25a5 36
  • 92 (a)
OneToMany
SLC25A5 (1 of 2) 36
  • 84 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ant2 36
  • 71 (a)
ManyToMany
sesB 36
  • 77 (a)
ManyToMany
sesB 37
  • 81 (a)
Ant2 37
  • 74 (a)
worm
(Caenorhabditis elegans)
Secernentea ant-1.1 36
  • 68 (a)
ManyToMany
ant-1.3 36
  • 67 (a)
ManyToMany
C47E12.2 36
  • 49 (a)
ManyToMany
F25B4.7 36
  • 47 (a)
ManyToMany
W02D3.6 37
  • 67 (a)
F25B4.7 37
  • 47 (a)
T01B11.4 37
  • 71 (a)
R07E3.4 37
  • 44 (a)
C47E12.2 37
  • 51 (a)
K01H12.2 37
  • 71 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAC1 36
  • 50 (a)
ManyToMany
AAC3 36
  • 52 (a)
ManyToMany
PET9 36
  • 50 (a)
ManyToMany
rice
(Oryza sativa)
Liliopsida Os.23386 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2354 36
  • 53 (a)
ManyToMany
Species with no ortholog for SLC25A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A5 Gene

ENSEMBL:
Gene Tree for SLC25A5 (if available)
TreeFam:
Gene Tree for SLC25A5 (if available)

Paralogs for SLC25A5 Gene

Paralogs for SLC25A5 Gene

Selected SIMAP similar genes for SLC25A5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC25A5: view

Variants for SLC25A5 Gene

Sequence variations from dbSNP and Humsavar for SLC25A5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs14544 -- 119,471,180(+) GAAAA(A/T)GGGAA utr-variant-3-prime
rs372646 -- 119,471,614(+) ATACT(A/G)TGAAC downstream-variant-500B
rs5910593 -- 119,471,704(+) tgaat(A/G)tcacc downstream-variant-500B
rs35099031 -- 119,471,473(+) AGTCC(A/G)CTTAA downstream-variant-500B
rs71820531 -- 119,471,777(+) GCCAT(-/TTT)TTTTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SLC25A5 Gene

Variant ID Type Subtype PubMed ID
esv2740427 CNV Deletion 23290073
esv2740429 CNV Deletion 23290073

Relevant External Links for SLC25A5 Gene

HapMap Linkage Disequilibrium report
SLC25A5
Human Gene Mutation Database (HGMD)
SLC25A5
Locus Specific Mutation Databases (LSDB)
SLC25A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A5 Gene

Disorders for SLC25A5 Gene

(5) Novoseek inferred disease relationships for SLC25A5 Gene

Disease -log(P) Hits PubMed IDs
oncocytoma 51.6 1
dilated cardiomyopathy 25.3 1
cancer 14.5 8
carcinoma renal cell 14.2 1
herpes simplex 12.1 3
genes like me logo Genes that share disorders with SLC25A5: view

No data available for UniProtKB/Swiss-Prot for SLC25A5 Gene

Publications for SLC25A5 Gene

  1. Ordered shotgun sequencing of a 135 kb Xq25 YAC containing ANT2 and four possible genes, including three confirmed by EST matches. (PMID: 8918809) Chen C.N. … Chen E. (Nucleic Acids Res. 1996) 3 4 23
  2. The human fibroblast adenine nucleotide translocator gene. Molecular cloning and sequence. (PMID: 2168878) Ku D.-H. … Wurzel J. (J. Biol. Chem. 1990) 2 3 4
  3. Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver. (PMID: 2829183) Houldsworth J. … Attardi G. (Proc. Natl. Acad. Sci. U.S.A. 1988) 2 3 4
  4. Molecular cloning of a cDNA for a human ADP/ATP carrier which is growth-regulated. (PMID: 3031073) Battini R. … Baserga R. (J. Biol. Chem. 1987) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SLC25A5 Gene

Sources for SLC25A5 Gene

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