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SLC25A5 Gene

protein-coding   GIFtS: 63
GCID: GC0XP118602

Solute Carrier Family 25 (Mitochondrial Carrier; Adenine...


(Previous symbol: ANT2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide
Translocator), Member 51 2
     2F12
ANT21 2 3 5     AAC22
Solute Carrier Family 25 Member 52 3     T22
ADP,ATP Carrier Protein 22 3     Adenine Nucleotide Translocator 2 (Fibroblast)2
ADP,ATP Carrier Protein, Fibroblast Isoform2 3     ADP/ATP Carrier Protein2
ANT 22 3     ADP/ATP Translocase 22
T32 5     Adenine Nucleotide Translocator 23

External Ids:    HGNC: 109911   Entrez Gene: 2922   Ensembl: ENSG000000050227   OMIM: 3001505   UniProtKB: P051413   

Export aliases for SLC25A5 gene to outside databases

Previous GC identifers: GC0XP113420 GC0XP115588 GC0XP116577 GC0XP117356 GC0XP118384 GC0XP118486 GC0XP108095


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC25A5 Gene:
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this
gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP
from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner
mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor
growth. The human genome contains several non-transcribed pseudogenes of this gene.(provided by RefSeq, Jun 2013)

GeneCards Summary for SLC25A5 Gene:
SLC25A5 (solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5) is a protein-coding gene. Diseases associated with SLC25A5 include treacher collins syndrome, and dilated cardiomyopathy. GO annotations related to this gene include adenine transmembrane transporter activity. An important paralog of this gene is SLC25A31.

UniProtKB/Swiss-Prot: ADT2_HUMAN, P05141
Function: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner
membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011786.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC25A5 gene promoter:
         PPAR-alpha   AP-1   ATF-2   MyoD   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC25A5 promoter sequence
   Search Chromatin IP Primers for SLC25A5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC25A5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq24   Ensembl cytogenetic band:  Xq24   HGNC cytogenetic band: Xq24

SLC25A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A5 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP118602:  view genomic region     (about GC identifiers)

Start:
118,602,363 bp from pter      End:
118,605,359 bp from pter
Size:
2,997 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ADT2_HUMAN, P05141 (See protein sequence)
Recommended Name: ADP/ATP translocase 2  
Size: 298 amino acids; 32852 Da
Subunit: Homodimer. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5.
Interacts with HIV-1 Vpr
Miscellaneous: The transmembrane helices are not perpendicular to the plane of the membrane, but cross the
membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved
proline residue (By similarity)
Secondary accessions: O43350

Explore the universe of human proteins at neXtProt for SLC25A5: NX_P05141

Explore proteomics data for SLC25A5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys43, Lys63, Lys105, Lys147, Lys163, Lys166, Lys245, Lys268, Lys272
  • Modification sites at PhosphoSitePlus

  • See SLC25A5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001143.2  
    ENSEMBL proteins: 
     ENSP00000360671  
    Reactome Protein details: P05141

    SLC25A5 Human Recombinant Protein Products:

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    Novus Biologicals SLC25A5 Protein
    Novus Biologicals SLC25A5 Lysates
    Browse Sino Biological Recombinant Proteins
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    Browse Proteins at Cloud-Clone Corp.

    SLC25A5 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Mitochondrial adenine nucleotide translocator 2
    Mitochondrial adenine nucleotide translocator family

    4 InterPro protein domains:
     IPR002067 Mit_carrier
     IPR023395 Mt_carrier_dom
     IPR018108 Mitochondrial_sb/sol_carrier
     IPR002113 Aden_trnslctor

    Graphical View of Domain Structure for InterPro Entry P05141

    ProtoNet protein and cluster: P05141

    2 Blocks protein domains:
    IPB002067 Mitochondrial carrier protein signature
    IPB002113 Adenine nucleotide translocator 1 signature


    UniProtKB/Swiss-Prot: ADT2_HUMAN, P05141
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 3 Solcar repeats


    SLC25A5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADT2_HUMAN, P05141
    Function: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner
    membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17715127
    GO:0015207adenine transmembrane transporter activity TAS2168878
    GO:0044822poly(A) RNA binding IDA--
         
    SLC25A5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC25A5:
     Increased S DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Slc25a5):
     cellular 

    SLC25A5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC25A5
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC25A5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC25A5

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLC25A5:
    hsa-mir-26a-5p (MIRT050085), hsa-mir-361-5p (MIRT044064), hsa-mir-10a-5p (MIRT047644), hsa-mir-106b-5p (MIRT044296), hsa-mir-27b-3p (MIRT046196), hsa-mir-3198 (MIRT052814), hsa-mir-877-5p (MIRT037259), hsa-mir-10b-5p (MIRT047467), hsa-mir-92b-3p (MIRT040669)

    Block miRNA regulation of human, mouse, rat SLC25A5 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate SLC25A5:
    hsa-miR-374c hsa-miR-3136-5p hsa-miR-137 hsa-miR-655 hsa-miR-3118 hsa-miR-134 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidSLC25A5 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat SLC25A5

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    GenScript: all cDNA clones in your preferred vector: SLC25A5 (NM_001152)
    Sino Biological Human cDNA Clone for SLC25A5
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A5

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADT2_HUMAN, P05141: Mitochondrion inner membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    mitochondrion5
    plasma membrane4
    cytosol2
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005887integral component of plasma membrane TAS2168878
    GO:0042645mitochondrial nucleoid IDA18063578
    GO:0071817MMXD complex IDA--

    SLC25A5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC25A5 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Electron Transport Chain0.75
    Huntington's disease0.45
    Parkinson's disease0.57
    2Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins
    Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins
    Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization0.00
    3Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Cellular Apoptosis Pathway0.85
    4Integration of energy metabolism
    Integration of energy metabolism0.75
    Regulation of Insulin Secretion0.75
    5HIV Life Cycle
    HIV Infection0.62
    Host Interactions of HIV factors0.60

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SLC25A5
        Mitochondrial Apoptosis
    Cellular Apoptosis Pathway

    1 Cell Signaling Technology (CST) Pathway for SLC25A5
        Glucose / Energy Metabolism

    1 GeneGo (Thomson Reuters) Pathway for SLC25A5
        Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

    1 BioSystems Pathway for SLC25A5
        Electron Transport Chain


    2 Reactome Pathways for SLC25A5
        Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
    Regulation of insulin secretion


    4 Kegg Pathways  (Kegg details for SLC25A5):
        Calcium signaling pathway
    Parkinson's disease
    Huntington's disease
    HTLV-I infection


    SLC25A5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC25A5: 
              Mitochondria in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLC25A5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SLC25A5 (P051411, 2, 3 ENSP000003606714) via UniProtKB, MINT, STRING, and/or I2D (see all 716)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CKMT1BP125322, 3, ENSP000003002834MINT-4054731 I2D: score=1 STRING: ENSP00000300283
    CKMT1AP125322, 3MINT-4054731 I2D: score=1 
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    NFKB1P198382, 3MINT-48534 MINT-48644 I2D: score=1 
    NOP56O005672, 3, ENSP000003705894MINT-6488791 I2D: score=1 STRING: ENSP00000370589
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006810transport TAS2168878
    GO:0007059chromosome segregation IEA--
    GO:0008284positive regulation of cell proliferation IMP19154410
    GO:0015853adenine transport TAS2168878

    SLC25A5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC25A5 (ADT2)

    1 DrugBank Compound for SLC25A5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Clodronate-- 10596-23-3targetinhibitor11961144

    5 Novoseek inferred chemical compound relationships for SLC25A5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adp 66.2 6 1885585 (1), 10393330 (1), 16107323 (1), 17715127 (1) (see all 5)
    atp 55.7 12 16982757 (1), 1885585 (1), 10393330 (1), 15691486 (1) (see all 10)
    chloramphenicol 22 2 1885585 (1)
    thymidine 7.8 3 9920880 (2), 15096217 (1)
    oxygen 0 2 16982757 (1), 15486956 (1)



    SLC25A5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC25A5 gene: 
    NM_001152.4  

    Unigene Cluster for SLC25A5:

    Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
    Hs.632282  [show with all ESTs]
    Unigene Representative Sequence: BF572346
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000317881(uc004erh.4) ENST00000475354 ENST00000460013 ENST00000463551

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate SLC25A5:
    hsa-miR-374c hsa-miR-3136-5p hsa-miR-137 hsa-miR-655 hsa-miR-3118 hsa-miR-134 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidSLC25A5 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC25A5
      QuantiFast Probe-based Assays in human, mouse, rat SLC25A5

    Additional mRNA sequence: 

    AK315292.1 BC056160.1 BC068199.1 J02683.1 J03591.1 L32786.1 

    Selected DOTS entries (see all 27):

    DT.455609  DT.100858440  DT.97868193  DT.91779764  DT.91965000  DT.100842536  DT.91779759  DT.100667146 
    DT.100712343  DT.95234692  DT.100667144  DT.100667148  DT.121310581  DT.91747330  DT.121043066  DT.95234715 
    DT.100653583  DT.100766676  DT.95234735  DT.121310645  DT.121310654  DT.40116823  DT.86858132  DT.91941964 

    Selected AceView cDNA sequences (see all 1324):

    BI260359 AU107032 AA167353 CR595951 CR597221 AI681835 BU950412 AA558346 
    BU952526 AA355731 BE618934 AW163616 AA581591 CR609949 AA307185 CR622988 
    AI310150 AI796701 BG576673 N71058 AA133592 CR616343 H97633 BQ924550 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC25A5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGGTGCTT
    SLC25A5 Expression
    About this image


    SLC25A5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Mature Choroid Plexus Cells Choroid Plexus
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Neurons
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
    SLC25A5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC25A5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632282
        Pathway & Disease-focused RT2 Profiler PCR Array including SLC25A5: 
              Mitochondria in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for SLC25A5
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    QuantiTect SYBR Green Assays in human, mouse, rat SLC25A5
    QuantiFast Probe-based Assays in human, mouse, rat SLC25A5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC25A5 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc25a51 , 5 solute carrier family 25 (mitochondrial carrier, adenine more1, 5 92.62(n)1
    98.32(a)1
      X (21.20 cM)5
    117401  NM_007451.31  NP_031477.11 
     367956515 
    chicken
    (Gallus gallus)
    Aves SLC25A51 solute carrier family 25 (mitochondrial carrier; adenine more 81.32(n)
    94.61(a)
      772225  XM_004940843.1  XP_004940900.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    91(a)
    91(a)
    1 ↔ many
    1 ↔ many
    3(109361766-109365599)
    3(113242633-113250605)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC043821.12   -- 80.88(n)    BC043821.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF506216.12   -- 81.94(n)   192321  AF506216.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sesB3 carrier 81(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea K01H12.23 ADP/ATP carrier protein 71(a)
    (best of 6)
      IV(9708187-9709272)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AAC36
    AAC16
    (see all 3)
    Mitochondrial inner membrane ADP/ATP translocator,...
    Mitochondrial inner membrane ADP/ATP translocator,...
    (see all 3)
    52(a)
    50(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    II(415983-416906) YBR085W
    XIII(387315-388244) YMR056C
    soybean
    (Glycine max)
    eudicotyledons 467911362   -- 72.93(n)  
    rice
    (Oryza sativa)
    Liliopsida Os.233862 Transcribed sequence with weak similarity to protein more 76.03(n)    CA759412.1 


    ENSEMBL Gene Tree for SLC25A5 (if available)
    TreeFam Gene Tree for SLC25A5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC25A5 gene
    SLC25A312  SLC25A62  SLC25A42  
    5 SIMAP similar genes for SLC25A5 using alignment to 2 protein entries:     ADT2_HUMAN (see all proteins):
    SLC25A6    SLC25A4    SLC25A31    SLC25A23    SLC25A24

    SLC25A5 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for SLC25A5 (see all 9)
    PGOHUM00000256731 PGOHUM00000246341 PGOHUM00000240010 PGOHUM00000245790 PGOHUM00000235278


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC25A5 (see all 161)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1841425231,2
    C--118596748(+) GATGGC/TGAGGT 1 -- us2k10--------
    rs1880283321,2
    --118596931(+) GCGAGG/TATCAC 1 -- us2k10--------
    rs1930936751,2
    --118597021(+) CACCAC/TAGCCT 1 -- us2k10--------
    rs1998569281,2
    C--118597190(+) ATCCT-/GGGGGG 1 -- us2k10--------
    rs1857964901,2
    C--118597296(+) CAAAGC/GCCTGC 1 -- us2k10--------
    rs128493361,2
    C,F--118597304(+) TGCTGA/GCATTT 1 -- us2k11Minor allele frequency- G:0.00NA 2
    rs1888757361,2
    --118597428(+) GATTAC/TACTAT 1 -- us2k10--------
    rs1814109591,2
    --118597501(+) TGTGGC/TAAATG 1 -- us2k10--------
    rs1844071041,2
    --118597512(+) CTTACA/CCAGTG 1 -- us2k10--------
    rs3920201,2
    C,F,A,H--118597661(-) ACGTTG/AACATT 1 -- us2k121Minor allele frequency- A:0.20NA EA NS WA CSA 2123

    HapMap Linkage Disequilibrium report for SLC25A5 (118602363 - 118605359 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SLC25A5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740429CNV Deletion23290073
    esv2740427CNV Deletion23290073

    Human Gene Mutation Database (HGMD): SLC25A5
    Locus Specific Mutation Databases (LSDB): SLC25A5

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC25A5
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC25A5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300150    OMIM disorders: --

    15 diseases for SLC25A5:    
    About MalaCards
    treacher collins syndrome    dilated cardiomyopathy    huntington's disease    herpes simplex
    choroiditis    parkinson's disease    hiv-1    ovarian cancer
    thyroiditis    neuroblastoma    breast cancer    pancreatitis
    prostate cancer    prostatitis    neuronitis


    SLC25A5 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for SLC25A5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oncocytoma 51.6 1 8781539 (1)
    dilated cardiomyopathy 25.3 1 16107323 (1)
    cancer 14.5 13 16341775 (2), 18267033 (2), 16982757 (1), 15486956 (1) (see all 6)
    carcinoma renal cell 14.2 1 8781539 (1)
    herpes simplex 12.1 3 9920880 (2), 15096217 (1)


    Export disorders for SLC25A5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC25A5 gene, integrated from 10 sources (see all 117):
    (articles sorted by number of sources associating them with SLC25A5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human fibroblast adenine nucleotide translocator gene. Molecular cloning and sequence. (PubMed id 2168878)1, 2, 3 Ku D.-H.... Wurzel J. (J. Biol. Chem. 1990)
    2. Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver. (PubMed id 2829183)1, 2, 3 Houldsworth J. and Attardi G. (Proc. Natl. Acad. Sci. U.S.A. 1988)
    3. Ordered shotgun sequencing of a 135 kb Xq25 YAC containing ANT2 and four possible genes, including three confirmed by EST matches. (PubMed id 8918809)1, 2, 9 Chen C.N.... Chen E. (Nucleic Acids Res. 1996)
    4. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Mitochondrial membrane permeabilization by HIV-1 Vpr. (PubMed id 16120388)1, 2 Deniaud A.... Kroemer G. (Mitochondrion 2004)
    7. Molecular cloning of a cDNA for a human ADP/ATP carrier which is growth-regulated. (PubMed id 3031073)1, 2 Battini R....Baserga R. (J. Biol. Chem. 1987)
    8. Suppression of adenine nucleotide translocase-2 by vector-based siRNA in human breast cancer cells induces apoptosis and inhibits tumor growth in vitro and in vivo. (PubMed id 18267033)1, 9 Jang J.Y....Kim C.W. (Breast Cancer Res. 2008)
    9. Repression of the human adenine nucleotide translocase-2 gene in growth-arrested human diploid cells: the role of nuclear factor-1. (PubMed id 12777383)1, 9 Luciakova K....Nelson B.D. (J. Biol. Chem. 2003)
    10. Growth-dependent repression of human adenine nucleotide translocator-2 (ANT2) transcription: evidence for the participation of Smad and Sp family proteins in the NF1-dependent repressor complex. (PubMed id 18215124)1, 9 Luciakova K....Nelson B.D. (Biochem. J. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 292 HGNC: 10991 AceView: SLC25A5 Ensembl:ENSG00000005022 euGenes: HUgn292
    ECgene: SLC25A5 Kegg: 292 H-InvDB: SLC25A5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC25A5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC25A5 gene:
    Search GeneIP for patents involving SLC25A5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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