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Aliases for SLC25A5 Gene

Aliases for SLC25A5 Gene

  • Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 5 2 3
  • ADP,ATP Carrier Protein, Fibroblast Isoform 3 4
  • ANT2 3 4
  • Adenine Nucleotide Translocator 2 (Fibroblast) 3
  • Adenine Nucleotide Translocator 2 4
  • Solute Carrier Family 25 Member 5 4
  • ADP,ATP Carrier Protein 2 4
  • ANT 2 4
  • AAC2 3
  • 2F1 3
  • T2 3
  • T3 3

External Ids for SLC25A5 Gene

Previous HGNC Symbols for SLC25A5 Gene

  • ANT2

Previous GeneCards Identifiers for SLC25A5 Gene

  • GC0XP113420
  • GC0XP115588
  • GC0XP116577
  • GC0XP117356
  • GC0XP118384
  • GC0XP118486
  • GC0XP118602
  • GC0XP108095

Summaries for SLC25A5 Gene

Entrez Gene Summary for SLC25A5 Gene

  • This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013]

GeneCards Summary for SLC25A5 Gene

SLC25A5 (Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 5) is a Protein Coding gene. Diseases associated with SLC25A5 include non-syndromic intellectual disability and prostatic adenoma. Among its related pathways are Infectious disease and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include poly(A) RNA binding and adenine transmembrane transporter activity. An important paralog of this gene is SLC25A4.

UniProtKB/Swiss-Prot for SLC25A5 Gene

  • Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A5 Gene

Genomics for SLC25A5 Gene

Regulatory Elements for SLC25A5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC25A5 Gene

Chromosome:
X
Start:
119,468,400 bp from pter
End:
119,471,396 bp from pter
Size:
2,997 bases
Orientation:
Plus strand

Genomic View for SLC25A5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for SLC25A5 Gene

Proteins for SLC25A5 Gene

  • Protein details for SLC25A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05141-ADT2_HUMAN
    Recommended name:
    ADP/ATP translocase 2
    Protein Accession:
    P05141
    Secondary Accessions:
    • B2RCV1
    • O43350

    Protein attributes for SLC25A5 Gene

    Size:
    298 amino acids
    Molecular mass:
    32852 Da
    Quaternary structure:
    • Homodimer. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with HIV-1 Vpr.
    Miscellaneous:
    • The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).

neXtProt entry for SLC25A5 Gene

Proteomics data for SLC25A5 Gene at MOPED

Post-translational modifications for SLC25A5 Gene

  • Ubiquitination at Lys 43, Lys 105, Lys 166, and Lys 245
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC25A5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SLC25A5 (SLC25A5)

No data available for DME Specific Peptides for SLC25A5 Gene

Domains & Families for SLC25A5 Gene

Gene Families for SLC25A5 Gene

Suggested Antigen Peptide Sequences for SLC25A5 Gene

Graphical View of Domain Structure for InterPro Entry

P05141

UniProtKB/Swiss-Prot:

ADT2_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A5: view

Function for SLC25A5 Gene

Molecular function for SLC25A5 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

Gene Ontology (GO) - Molecular Function for SLC25A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17715127
GO:0015207 adenine transmembrane transporter activity TAS 2168878
GO:0031625 ubiquitin protein ligase binding IPI 19725078
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SLC25A5: view

Phenotypes for SLC25A5 Gene

genes like me logo Genes that share phenotypes with SLC25A5: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC25A5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A5 Gene

Localization for SLC25A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A5 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A5 Gene COMPARTMENTS Subcellular localization image for SLC25A5 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
mitochondrion 5
nucleus 5
plasma membrane 4
chloroplast 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC25A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA 20833797
GO:0005743 mitochondrial inner membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2168878
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with SLC25A5: view

Pathways & Interactions for SLC25A5 Gene

genes like me logo Genes that share pathways with SLC25A5: view

Pathways by source for SLC25A5 Gene

2 Qiagen pathways for SLC25A5 Gene
1 Cell Signaling Technology pathway for SLC25A5 Gene
1 BioSystems pathway for SLC25A5 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Mitochondria in human,mouse,rat

Gene Ontology (GO) - Biological Process for SLC25A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0006810 transport TAS 2168878
GO:0007059 chromosome segregation IEA --
GO:0008284 positive regulation of cell proliferation IMP 19154410
GO:0015853 adenine transport TAS 2168878
genes like me logo Genes that share ontologies with SLC25A5: view

No data available for SIGNOR curated interactions for SLC25A5 Gene

Drugs & Compounds for SLC25A5 Gene

(4) Drugs for SLC25A5 Gene - From: NovoSeek, DGIdb, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clodronate Approved, Investigational Pharma inhibitor, Target 0
Chloramphenicol Approved Pharma 6
thymidine Experimental Pharma 0
ATP Pharma Activator 0

(2) Additional Compounds for SLC25A5 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
genes like me logo Genes that share compounds with SLC25A5: view

Transcripts for SLC25A5 Gene

mRNA/cDNA for SLC25A5 Gene

Unigene Clusters for SLC25A5 Gene

Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC25A5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A5 Gene

No ASD Table

Relevant External Links for SLC25A5 Gene

GeneLoc Exon Structure for
SLC25A5
ECgene alternative splicing isoforms for
SLC25A5

Expression for SLC25A5 Gene

mRNA expression in normal human tissues for SLC25A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC25A5 Gene

This gene is overexpressed in Nasal epithelium (23.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A5 Gene



SOURCE GeneReport for Unigene cluster for SLC25A5 Gene Hs.632282

genes like me logo Genes that share expression patterns with SLC25A5: view

Protein tissue co-expression partners for SLC25A5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC25A5 Gene

Orthologs for SLC25A5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC25A5 35
  • 93.18 (n)
  • 97.99 (a)
SLC25A5 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A5 35
  • 94.18 (n)
  • 97.32 (a)
SLC25A5 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a5 35
  • 92.62 (n)
  • 98.32 (a)
Slc25a5 16
Slc25a5 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a5 35
  • 93.06 (n)
  • 98.66 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia SLC25A5 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC25A5 35
  • 81.32 (n)
  • 94.61 (a)
SLC25A6 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 91 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75700 35
  • 80.81 (n)
  • 91.92 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
slc25a5 35
  • 81.98 (n)
  • 92.91 (a)
slc25a5 36
  • 92 (a)
OneToMany
SLC25A5 (1 of 2) 36
  • 84 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ant2 37
  • 74 (a)
sesB 37
  • 81 (a)
Ant2 36
  • 71 (a)
ManyToMany
sesB 36
  • 77 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C47E12.2 37
  • 51 (a)
F25B4.7 37
  • 47 (a)
K01H12.2 37
  • 71 (a)
R07E3.4 37
  • 44 (a)
T01B11.4 37
  • 71 (a)
W02D3.6 37
  • 67 (a)
ant-1.1 36
  • 68 (a)
ManyToMany
ant-1.3 36
  • 67 (a)
ManyToMany
C47E12.2 36
  • 49 (a)
ManyToMany
F25B4.7 36
  • 47 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAC1 36
  • 50 (a)
ManyToMany
AAC3 36
  • 52 (a)
ManyToMany
PET9 36
  • 50 (a)
ManyToMany
rice
(Oryza sativa)
Liliopsida Os.23386 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2354 36
  • 53 (a)
ManyToMany
Species with no ortholog for SLC25A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A5 Gene

ENSEMBL:
Gene Tree for SLC25A5 (if available)
TreeFam:
Gene Tree for SLC25A5 (if available)

Paralogs for SLC25A5 Gene

Paralogs for SLC25A5 Gene

(5) SIMAP similar genes for SLC25A5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC25A5: view

Variants for SLC25A5 Gene

Sequence variations from dbSNP and Humsavar for SLC25A5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs14544 -- 119,471,180(+) GAAAA(A/T)GGGAA utr-variant-3-prime
rs372646 -- 119,471,614(+) ATACT(A/G)TGAAC downstream-variant-500B
rs5910593 -- 119,471,704(+) tgaat(A/G)tcacc downstream-variant-500B
rs35099031 -- 119,471,473(+) AGTCC(A/G)CTTAA downstream-variant-500B
rs71820531 -- 119,471,777(+) GCCAT(-/TTT)TTTTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SLC25A5 Gene

Variant ID Type Subtype PubMed ID
esv2740427 CNV Deletion 23290073
esv2740429 CNV Deletion 23290073

Variation tolerance for SLC25A5 Gene

Residual Variation Intolerance Score: 62.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A5 Gene

HapMap Linkage Disequilibrium report
SLC25A5
Human Gene Mutation Database (HGMD)
SLC25A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A5 Gene

Disorders for SLC25A5 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SLC25A5 Gene - From: DISEASES, NovoSeek, and GeneCards

- elite association

Relevant External Links for SLC25A5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A5
genes like me logo Genes that share disorders with SLC25A5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC25A5 Gene

Publications for SLC25A5 Gene

  1. Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis. (PMID: 19154410) Kashiwaya K. … Nakagawa H. (Cancer Sci. 2009) 23 67
  2. Over-expression of adenine nucleotide translocase 1 (ANT1) induces apoptosis and tumor regression in vivo. (PMID: 18522758) Jang J.Y. … Kim C.W. (BMC Cancer 2008) 23 67
  3. Growth-dependent repression of human adenine nucleotide translocator-2 (ANT2) transcription: evidence for the participation of Smad and Sp family proteins in the NF1-dependent repressor complex. (PMID: 18215124) Luciakova K. … Nelson B.D. (Biochem. J. 2008) 23 67
  4. Suppression of adenine nucleotide translocase-2 by vector-based siRNA in human breast cancer cells induces apoptosis and inhibits tumor growth in vitro and in vivo. (PMID: 18267033) Jang J.Y. … Kim C.W. (Breast Cancer Res. 2008) 23 67
  5. Regulation of insulin secretion by SIRT4, a mitochondrial ADP- ribosyltransferase. (PMID: 17715127) Ahuja N. … Verdin E. (J. Biol. Chem. 2007) 23 67

Products for SLC25A5 Gene

Sources for SLC25A5 Gene

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