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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC25A5 Gene

protein-coding GIFtS: 59
GCID: GC0XP118602

solute carrier family 25 (mitochondrial carrier; adenine...

(Previous symbol: ANT2)

Explore 11 diseases affiliated with
SLC25A5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 5¹ ²		ADP,ATP Carrier Protein, Fibroblast Isoform² ³
ANT2¹ ² ³ ⁵		ANT 2² ³
T3¹ ² ⁵		AAC2²
2F1¹ ²		Adenine Nucleotide Translocator 2 (Fibroblast)²
T2¹ ²		ADP/ATP Carrier Protein²
Solute Carrier Family 25 Member 5² ³		ADP/ATP Translocase 2²
ADP,ATP Carrier Protein 2² ³		Adenine Nucleotide Translocator 2³

External Ids:	HGNC: 10991¹	Entrez Gene: 292²	Ensembl: ENSG00000005022⁷	OMIM: 300150⁵	UniProtKB: P05141³

Export aliases for SLC25A5 gene to outside databases

Previous GC identifers: GC0XP113420 GC0XP115588 GC0XP116577 GC0XP117356 GC0XP118384 GC0XP118486 GC0XP108095

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC25A5:

This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene

functions as a gated pore that translocates ADP from the mitochondrial matrix into the cytoplasm. The protein forms a

homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce

apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this

gene.(provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: ADT2_HUMAN, P05141

Function: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As

part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_011786.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC25A5 gene promoter:
PPAR-alpha AP-1 ATF-2 MyoD STAT3 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC25A5 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC25A5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC25A5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq24 Ensembl cytogenetic band: Xq24 HGNC cytogenetic band: Xq24

SLC25A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A5 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP118602: view genomic region (about GC identifiers)

Start:	118,602,363 bp from pter	End:	118,605,359 bp from pter
Size:	2,997 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADT2_HUMAN, P05141 (See protein sequence)

Recommended Name: ADP/ATP translocase 2

Size: 298 amino acids; 32852 Da

Subunit: Homodimer. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts

with HIV-1 Vpr

Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein

Miscellaneous: The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at

an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue

(By similarity)

Secondary accessions: O43350

Explore the universe of human proteins at neXtProt for SLC25A5: NX_P05141

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P05141

SLC25A5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001143.2

ENSEMBL proteins:

ENSP00000360671

Reactome Protein details: P05141
Human Recombinant Protein Products for SLC25A5:

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	Novus Biologicals SLC25A5 Protein Novus Biologicals SLC25A5 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SLC25A5

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	--	--
GO:0005743	mitochondrial inner membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	2168878
GO:0042645	mitochondrial nucleoid	IDA	18063578
GO:0071817	MMXD complex	IDA	--

SLC25A5 for ontologies About GeneDecksing

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	Search ThermoFisher Antibodies for SLC25A5

Assay Products for SLC25A5:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for SLC25A5
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	Uscn ELISAs and CLIAs for SLC25A5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC25A5 for domains About GeneDecksing

4 InterPro domains/families:

IPR002067 Mit_carrier

IPR023395 Mt_carrier_dom

IPR018108 Mitochondrial_sb/sol_carrier

IPR002113 Aden_trnslctor

Graphical View of Domain Structure for InterPro Entry P05141

ProtoNet protein and cluster: P05141

2 Blocks protein families:

IPB002067 Mitochondrial carrier protein signature

IPB002113 Adenine nucleotide translocator 1 signature

UniProtKB/Swiss-Prot: ADT2_HUMAN, P05141

Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family

Similarity: Contains 3 Solcar repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ADT2_HUMAN, P05141

Function: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As

part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	17715127
GO:0015207	adenine transmembrane transporter activity	TAS	2168878

SLC25A5 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for SLC25A5:

Increased S DNA content

2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Slc25a5):

cellular

hearing/vestibular/ear

SLC25A5 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC25A5

miRNA Products:		OriGene 3'-UTR Clone: SLC25A5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC25A5
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC25A5:
		hsa-miR-374c hsa-miR-3136-5p hsa-miR-137 hsa-miR-655 hsa-miR-3118 hsa-miR-134 hsa-miR-1305
		SwitchGear 3'UTR luciferase reporter plasmid: SLC25A5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC25A5 (see all 7) OriGene shRNA RFP: SLC25A5 OriGene siRNA: SLC25A5
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SLC25A5
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SLC25A5

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

	Electron Transport Chain	0.76			Huntington's disease	0.40
	Parkinson's disease	0.61

HIV Infection

HIV Infection

1.00

Host Interactions of HIV factors

0.64

Regulation of Insulin Secretion

Regulation of Insulin Secretion

1.00

Integration of energy metabolism

0.74

Apoptotic Pathways in Synovial Fibroblasts

Mitochondrial Apoptosis

0.73

Cellular Apoptosis Pathway

0.65

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

0.24

Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins

0.24

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for SLC25A5

Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SLC25A5

	Mitochondrial Apoptosis
	Cellular Apoptosis Pathway

1 GeneGo (Thomson Reuters) Pathway for SLC25A5

Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

1 BioSystems Pathway for SLC25A5

Electron Transport Chain

5/8 Reactome Pathways for SLC25A5 (see all 8)

	HIV Infection
	Metabolism
	Interactions of Vpr with host cellular proteins
	Regulation of Insulin Secretion
	Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization

3 Kegg Pathways (Kegg details for SLC25A5):

	Calcium signaling pathway
	Parkinson's disease
	Huntington's disease

SLC25A5 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SLC25A5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/649 Interacting proteins for SLC25A5 (P05141^{1, 2, 3} ENSP00000360671⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 649)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CKMT1B	P12532²^,³, ENSP00000300283⁴	MINT-4054731 I2D: score=1 STRING: ENSP00000300283
CKMT1A	P12532²^,³	MINT-4054731 I2D: score=1
ICT1	Q14197²^,³, ENSP00000301585⁴	MINT-8079030 I2D: score=1 STRING: ENSP00000301585
NFKB1	P19838²^,³	MINT-48534 MINT-48644 I2D: score=1
NOP56	O00567²^,³, ENSP00000370589⁴	MINT-6488791 I2D: score=1 STRING: ENSP00000370589

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006112	energy reserve metabolic process	TAS	--
GO:0006810	transport	TAS	2168878
GO:0007059	chromosome segregation	IEA	--
GO:0008284	positive regulation of cell proliferation	IMP	19154410
GO:0015853	adenine transport	TAS	2168878

SLC25A5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SLC25A5 for compounds About GeneDecksing

EMD Millipore small molecules for SLC25A5:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC25A5

1 DrugBank Compound for SLC25A5 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Clodronate	--	10596-23-3	target	inhibitor	11961144

5 Novoseek chemical compound relationships for SLC25A5 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
adp	66.2	6	1885585 (1), 10393330 (1), 16107323 (1), 17715127 (1) (see all 5)
atp	55.7	12	16982757 (1), 1885585 (1), 10393330 (1), 15691486 (1) (see all 10)
chloramphenicol	22	2	1885585 (1)
thymidine	7.8	3	9920880 (2), 15096217 (1)
oxygen	0	2	16982757 (1), 15486956 (1)

Search CenterWatch for drugs/clinical trials and news about SLC25A5 / ADT2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC25A5 gene:

NM_001152.4

Unigene Cluster for SLC25A5:

Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5

Hs.632282 [show with all ESTs]

Unigene Representative Sequence: BM913159

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000317881(uc004erh.4) ENST00000475354 ENST00000460013 ENST00000463551

miRNA Products:		OriGene 3'-UTR Clone: SLC25A5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC25A5
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC25A5:
		hsa-miR-374c hsa-miR-3136-5p hsa-miR-137 hsa-miR-655 hsa-miR-3118 hsa-miR-134 hsa-miR-1305
		SwitchGear 3'UTR luciferase reporter plasmid: SLC25A5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: SLC25A5 (NM_001152)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC25A5

Additional cDNA sequence:

AK315292.1 BC056160.1 BC068199.1 J02683.1 J03591.1 L32786.1

24/26 DOTS entries (see all 26):

DT.455609 DT.100858440 DT.97868193 DT.91779764 DT.91965000 DT.100842536 DT.91779759 DT.100667146

DT.100712343 DT.95234692 DT.100667148 DT.121310581 DT.100667144 DT.91747330 DT.95234715 DT.100653583

DT.100766676 DT.95234735 DT.121310645 DT.121310654 DT.40116823 DT.86858132 DT.91941964 DT.95234694

24/1324 AceView cDNA sequences (see all 1324):

AI929525 CR625934 CR622239 H20511 CR607905 BM907312 CA308130 BM686161

BE866596 BP871413 BF212868 AW731674 BM312180 BM701735 AA294933 CR609751

AW104656 BM473801 AA369821 AA581591 CA455387 AU120823 BU726139 AI493709

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC25A5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTGGTGCTT

About this image

SLC25A5 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Choroid Plexus

Mature Choroid Plexus Cells

Selective marker (cell-identifying gene)

Choroid Plexus

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLC25A5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC25A5

SOURCE GeneReport for Unigene cluster: Hs.632282

SABiosciences Expression via Pathway-Focused PCR Array including SLC25A5:

Mitochondria in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC25A5 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC25A5

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SLC25A5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A5 gene from 6/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
African clawed frog (Xenopus laevis)	Amphibia	BC043821.1²	--	80.88(n)		BC043821.1
zebrafish (Danio rerio)	Actinopterygii	AF506216.1²	--	81.94(n)		192321 AF506216.1
fruit fly (Drosophila melanogaster)	Insecta	sesB³	carrier	81(a) (best of 2)		--
worm (Caenorhabditis elegans)	Secernentea	K01H12.2³	ADP/ATP carrier protein	71(a) (best of 6)		IV(9708187-9709272) --
thale cress (Arabidopsis thaliana)	eudicotyledons	ER-ANT1⁶ AT5G56450⁶ (see all 5)	solute carrier family 25 protein (see all 5)	45(a) 43(a) (see all 5)	possible ortholog 1 ↔ many (see all 5)	5(5728789-5730376) 5(22858509-22860062)
rice (Oryza sativa)	Liliopsida	Os.23386²	Transcribed sequence with weak similarity to protein more	76.03(n)		CA759412.1

ENSEMBL Gene Tree for SLC25A5 (if available)
TreeFam Gene Tree for SLC25A5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC25A5 gene

SLC25A31² SLC25A6² SLC25A4²

5 SIMAP similar genes for SLC25A5 using alignment to 2 protein entries: ADT2_HUMAN (see all proteins):

SLC25A6 SLC25A4 SLC25A31 SLC25A23 SLC25A24

SLC25A5 for paralogs About GeneDecksing

5/9 Pseudogenes.org Pseudogenes for SLC25A5 (see all 9)
PGOHUM00000256731 PGOHUM00000246341 PGOHUM00000240010 PGOHUM00000245790 PGOHUM00000235278

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs28622444^1,2	C	--	108095219(+)	`ACTGAA/GGGGTT`	1	--	us2k¹		1		NA	2
rs405050^1,2	C	--	108095340(+)	`CTCAGA/GGTCCA`	1	--	us2k¹		1		WA	2
rs62599439^1,2	C	--	108095410(+)	`AGGGCC/GAGCAC`	1	--	us2k¹		1		NA	2
rs62599440^1,2		--	108095434(+)	`AGCAGC/TCCCGG`	1	--	us2k¹		0	--	--	--	--
rs113618375^1,2	C	--	108096856(+)	`TACAAG/AGGCAT`	2	/K	syn¹		1		CSA	2
rs11552290^1,2	C	--	108097031(+)	`TTTGGC/TGCTAC`	2	L F	mis¹		1		NA	2
rs11552291^1,2		--	108097196(+)	`TCTACA/GAATCT`	2	K E	mis¹ ese³		0	--	--	--	--
rs421313^1,2	C	--	108097377(-)	`TTAGCT/GCTTGG`	1	--	int¹		1		NA	2
rs2873091^1,2		--	108097451(+)	`ACGATG/TGTTAG`	1	--	int¹		0	--	--	--	--
rs2873092^1,2		--	108097453(+)	`CGATTG/TTTAGG`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SLC25A5 (118602363 - 118605359 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for SLC25A5
7 Indels: 83708 96923 83705 96925 83707 96924 83706
Locus Specific Mutation Databases (LSDB): SLC25A5

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC25A5 for disorders           About GeneDecksing

OMIM gene information: 300150    OMIM disorders: --

11 diseases for SLC25A5:    About MalaCards

treacher collins syndrome dilated cardiomyopathy x inactivation cardiomyopathy

huntington's disease parkinson's disease breast cancer thyroiditis

carcinoma pancreatitis malaria

5 Novoseek disease relationships for SLC25A5 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
oncocytoma	51.6	1	8781539 (1)
dilated cardiomyopathy	25.3	1	16107323 (1)
cancer	14.5	13	16341775 (2), 18267033 (2), 16982757 (1), 15486956 (1) (see all 6)
carcinoma renal cell	14.2	1	8781539 (1)
herpes simplex	12.1	3	9920880 (2), 15096217 (1)

Export disorders for SLC25A5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLC25A5 gene, integrated from 9 sources (see all 91):
(articles sorted by number of sources associating them with SLC25A5)

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world of online information

The human fibroblast adenine nucleotide translocator gene. Molecular cloning and sequence. (PubMed id 2168878)^{1, 2, 3} Ku D.-H.... Wurzel J. (1990)
Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver. (PubMed id 2829183)^{1, 2, 3} Houldsworth J. and Attardi G. (1988)
Ordered shotgun sequencing of a 135 kb Xq25 YAC containing ANT2 and four possible genes, including three confirmed by EST matches. (PubMed id 8918809)^{1, 2, 9} Chen C.N.... Chen E. (1996)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Mitochondrial membrane permeabilization by HIV-1 Vpr. (PubMed id 16120388)^{1, 2} Deniaud A.... Kroemer G. (2004)
Molecular cloning of a cDNA for a human ADP/ATP carrier which is growth-regulated. (PubMed id 3031073)^{1, 2} Battini R....Baserga R. (1987)
Suppression of adenine nucleotide translocase-2 by vector-based siRNA in human breast cancer cells induces apoptosis and inhibits tumor growth in vitro and in vivo. (PubMed id 18267033)^{1, 9} Jang J.Y....Kim C.W. (2008)
Repression of the human adenine nucleotide translocase-2 gene in growth-arrested human diploid cells: the role of nuclear factor-1. (PubMed id 12777383)^{1, 9} Luciakova K....Nelson B.D. (2003)
Growth-dependent repression of human adenine nucleotide translocator-2 (ANT2) transcription: evidence for the participation of Smad and Sp family proteins in the NF1-dependent repressor complex. (PubMed id 18215124)^{1, 9} Luciakova K....Nelson B.D. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 292	HGNC: 10991	AceView: SLC25A5	Ensembl:ENSG00000005022	euGenes: HUgn292
ECgene: SLC25A5	Kegg: 292	H-InvDB: SLC25A5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLC25A5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC25A5 gene
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Patent Information for SLC25A5 gene:
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GeneCards and IP:
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