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Aliases for SLC25A47 Gene

Aliases for SLC25A47 Gene

  • Solute Carrier Family 25 Member 47 2 3 5
  • Hepatocellular Carcinoma Down-Regulated Mitochondrial Carrier Protein 3 4
  • C14orf68 3 4
  • HDMCP 3 4
  • Hepatocellular Carcinoma-Downregulated Mitochondrial Carrier Protein 3
  • HCC-Down-Regulated Mitochondrial Carrier Protein 3
  • Chromosome 14 Open Reading Frame 68 2
  • Solute Carrier Family 25, Member 47 2
  • HMFN1655 3

External Ids for SLC25A47 Gene

Previous HGNC Symbols for SLC25A47 Gene

  • C14orf68

Previous GeneCards Identifiers for SLC25A47 Gene

  • GC14P101010
  • GC14P080971
  • GC14P101022
  • GC14P101033
  • GC14P101047
  • GC14P101077
  • GC14P101114
  • GC14P101163
  • GC14P101225

Summaries for SLC25A47 Gene

GeneCards Summary for SLC25A47 Gene

SLC25A47 (Solute Carrier Family 25 Member 47) is a Protein Coding gene. An important paralog of this gene is SLC25A45.

UniProtKB/Swiss-Prot for SLC25A47 Gene

  • Uncoupling protein which may catalyze the physiological proton leak in liver. Overexpression induces the dissipation of mitochondrial membrane potential.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A47 Gene

Genomics for SLC25A47 Gene

Regulatory Elements for SLC25A47 Gene

Enhancers for SLC25A47 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F100294 0.2 ENCODE 11.6 -29.0 -29049 0.3 ZNF341 HMBOX1 EBF1 SLC25A47 WARS WDR25 ENSG00000259052 SLC25A29
GH14F100296 0.2 ENCODE 11.6 -28.0 -27953 0.2 NFRKB BHLHE40 GABPA POLR2H FOSL1 FOS SP7 NFE2L2 SLC25A29 SLC25A47 WARS WDR25 ENSG00000259052
GH14F100290 0.6 ENCODE 11.6 -32.4 -32361 1.3 ELF3 TBP MLX ARID4B DMAP1 RARA GLIS2 CREM MIXL1 THAP11 SLC25A47 WARS WDR25 ENSG00000258504 PIR46113
GH14F100284 1.1 FANTOM5 Ensembl ENCODE 11.2 -38.0 -38019 2.6 HDGF MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 WDR25 WARS SLC25A47 PIR46113 GC14P100279
GH14F100383 0.5 Ensembl ENCODE 10.7 +65.9 65859 11.2 PKNOX1 SIN3A ZNF2 ZNF48 YY1 SLC30A9 GLIS2 CBX5 ELK1 ZNF143 WARS WDR25 SLC25A47 BEGAIN MIR337 MIR493 MIR127 MIR431 MIR433 MIR136
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SLC25A47 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A47 Gene

Chromosome:
14
Start:
100,323,337 bp from pter
End:
100,330,378 bp from pter
Size:
7,042 bases
Orientation:
Plus strand

Genomic View for SLC25A47 Gene

Genes around SLC25A47 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A47 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A47 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A47 Gene

Proteins for SLC25A47 Gene

  • Protein details for SLC25A47 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6Q0C1-S2547_HUMAN
    Recommended name:
    Solute carrier family 25 member 47
    Protein Accession:
    Q6Q0C1
    Secondary Accessions:
    • B2RP39
    • Q68CL2
    • Q6PZD8
    • Q86U14

    Protein attributes for SLC25A47 Gene

    Size:
    308 amino acids
    Molecular mass:
    33435 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD38636.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=CAD62588.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC25A47 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A47 Gene

Post-translational modifications for SLC25A47 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A47 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A47 Gene

Domains & Families for SLC25A47 Gene

Gene Families for SLC25A47 Gene

Protein Domains for SLC25A47 Gene

Suggested Antigen Peptide Sequences for SLC25A47 Gene

Graphical View of Domain Structure for InterPro Entry

Q6Q0C1

UniProtKB/Swiss-Prot:

S2547_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A47: view

Function for SLC25A47 Gene

Molecular function for SLC25A47 Gene

UniProtKB/Swiss-Prot Function:
Uncoupling protein which may catalyze the physiological proton leak in liver. Overexpression induces the dissipation of mitochondrial membrane potential.
UniProtKB/Swiss-Prot Induction:
Down-regulated in hepatocarcinoma.
genes like me logo Genes that share phenotypes with SLC25A47: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A47

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC25A47 Gene

Localization for SLC25A47 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A47 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A47 Gene COMPARTMENTS Subcellular localization image for SLC25A47 gene
Compartment Confidence
mitochondrion 4
extracellular 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC25A47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC25A47: view

Pathways & Interactions for SLC25A47 Gene

SuperPathways for SLC25A47 Gene

No Data Available

Interacting Proteins for SLC25A47 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354886%0d%0a9606.ENSP00000398495%0d%0a9606.ENSP00000363773%0d%0a
Selected Interacting proteins: ENSP00000354886 Q6Q0C1-S2547_HUMAN for SLC25A47 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLC25A47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A47: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A47 Gene

Transcripts for SLC25A47 Gene

mRNA/cDNA for SLC25A47 Gene

Unigene Clusters for SLC25A47 Gene

Solute carrier family 25, member 47:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A47 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: -
SP2:

Relevant External Links for SLC25A47 Gene

GeneLoc Exon Structure for
SLC25A47
ECgene alternative splicing isoforms for
SLC25A47

Expression for SLC25A47 Gene

mRNA expression in normal human tissues for SLC25A47 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A47 Gene

This gene is overexpressed in Liver (x52.1).

Protein differential expression in normal tissues from HIPED for SLC25A47 Gene

This gene is overexpressed in Spleen (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC25A47 Gene



Protein tissue co-expression partners for SLC25A47 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC25A47 Gene:

SLC25A47

SOURCE GeneReport for Unigene cluster for SLC25A47 Gene:

Hs.108268

mRNA Expression by UniProt/SwissProt for SLC25A47 Gene:

Q6Q0C1-S2547_HUMAN
Tissue specificity: Specifically expressed in liver.
genes like me logo Genes that share expression patterns with SLC25A47: view

Primer Products

Orthologs for SLC25A47 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A47 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A47 34 35
  • 98.59 (n)
dog
(Canis familiaris)
Mammalia SLC25A47 34 35
  • 87.83 (n)
cow
(Bos Taurus)
Mammalia SLC25A47 34 35
  • 86.1 (n)
mouse
(Mus musculus)
Mammalia Slc25a47 34 16 35
  • 83.33 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a47 34
  • 83.23 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC25A47 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A47 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC25A47 34 35
  • 64.58 (n)
lizard
(Anolis carolinensis)
Reptilia SLC25A47 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a47 34
  • 57.55 (n)
zebrafish
(Danio rerio)
Actinopterygii slc25a47b 34 35
  • 58.45 (n)
slc25a47a 35
  • 54 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5646 35
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R07B7.10 35
  • 34 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YMC1 35
  • 28 (a)
ManyToMany
YMC2 35
  • 26 (a)
ManyToMany
Species where no ortholog for SLC25A47 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A47 Gene

ENSEMBL:
Gene Tree for SLC25A47 (if available)
TreeFam:
Gene Tree for SLC25A47 (if available)

Paralogs for SLC25A47 Gene

Paralogs for SLC25A47 Gene

(10) SIMAP similar genes for SLC25A47 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SLC25A47 Gene

genes like me logo Genes that share paralogs with SLC25A47: view

Variants for SLC25A47 Gene

Sequence variations from dbSNP and Humsavar for SLC25A47 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs193920797 Uncertain significance 100,325,815(+) CTACC(C/T)CCTGG reference, missense
rs10140039 -- 100,330,159(+) CCGGC(C/T)CGGCT utr-variant-3-prime
rs10144242 -- 100,328,067(+) GAGTC(C/T)GACAT intron-variant
rs10147903 -- 100,329,326(+) GCCCC(A/G)ATCAG intron-variant
rs111484888 -- 100,321,894(+) TTGAG(A/G)GCCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC25A47 Gene

Variant ID Type Subtype PubMed ID
nsv832875 CNV loss 17160897

Variation tolerance for SLC25A47 Gene

Residual Variation Intolerance Score: 67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.59; 56.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A47 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A47

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A47 Gene

Disorders for SLC25A47 Gene

Relevant External Links for SLC25A47

Genetic Association Database (GAD)
SLC25A47
Human Genome Epidemiology (HuGE) Navigator
SLC25A47
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A47

No disorders were found for SLC25A47 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A47 Gene

Publications for SLC25A47 Gene

  1. Cloning and identification of hepatocellular carcinoma down-regulated mitochondrial carrier protein, a novel liver-specific uncoupling protein. (PMID: 15322095) Tan M.G.K. … Hui K.M. (J. Biol. Chem. 2004) 3 4 22 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S. … Nakagawara A. (Oncogene 2004) 3 4 64
  5. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F. (Mol. Aspects Med. 2013) 3 64

Products for SLC25A47 Gene

Sources for SLC25A47 Gene

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