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Aliases for SLC25A47 Gene

Aliases for SLC25A47 Gene

  • Solute Carrier Family 25, Member 47 2 3
  • C14orf68 3 4 6
  • HDMCP 3 4 6
  • Hepatocellular Carcinoma Down-Regulated Mitochondrial Carrier Protein 3 4
  • Hepatocellular Carcinoma-Downregulated Mitochondrial Carrier Protein 3
  • HCC-Down-Regulated Mitochondrial Carrier Protein 3
  • Chromosome 14 Open Reading Frame 68 2
  • Solute Carrier Family 25 Member 47 3
  • HMFN1655 3

External Ids for SLC25A47 Gene

Previous Symbols for SLC25A47 Gene

  • C14orf68

Summaries for SLC25A47 Gene

GeneCards Summary for SLC25A47 Gene

SLC25A47 (Solute Carrier Family 25, Member 47) is a Protein Coding gene. Diseases associated with SLC25A47 include hepatocellular carcinoma. An important paralog of this gene is SLC25A20.

UniProtKB/Swiss-Prot for SLC25A47 Gene

  • Uncoupling protein which may catalyze the physiological proton leak in liver. Overexpression induces the dissipation of mitochondrial membrane potential.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A47 Gene

Genomics for SLC25A47 Gene

Genomic Location for SLC25A47 Gene

Start:
100,323,337 bp from pter
End:
100,330,378 bp from pter
Size:
7,042 bases
Orientation:
Plus strand

Genomic View for SLC25A47 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC25A47 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A47 Gene

No data available for Regulatory Elements for SLC25A47 Gene

Proteins for SLC25A47 Gene

  • Protein details for SLC25A47 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6Q0C1-S2547_HUMAN
    Recommended name:
    Solute carrier family 25 member 47
    Protein Accession:
    Q6Q0C1
    Secondary Accessions:
    • B2RP39
    • Q68CL2
    • Q6PZD8
    • Q86U14

    Protein attributes for SLC25A47 Gene

    Size:
    308 amino acids
    Molecular mass:
    33435 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD38636.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=CAD62588.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC25A47 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A47 Gene

Proteomics data for SLC25A47 Gene at MOPED

Post-translational modifications for SLC25A47 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A47 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A47 Gene

Domains for SLC25A47 Gene

Gene Families for SLC25A47 Gene

HGNC:
  • SLC :Solute carriers

Protein Domains for SLC25A47 Gene

UniProtKB/Swiss-Prot:

S2547_HUMAN
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.:
    • Q6Q0C1
Similarity:
  • Contains 3 Solcar repeats.:
    • Q6Q0C1
genes like me logo Genes that share domains with SLC25A47: view

Function for SLC25A47 Gene

Molecular function for SLC25A47 Gene

UniProtKB/Swiss-Prot Function: Uncoupling protein which may catalyze the physiological proton leak in liver. Overexpression induces the dissipation of mitochondrial membrane potential.
UniProtKB/Swiss-Prot Induction: Down-regulated in hepatocarcinoma.

Phenotypes for SLC25A47 Gene

GenomeRNAi human phenotypes for SLC25A47:
genes like me logo Genes that share phenotypes with SLC25A47: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC25A47 Gene

Localization for SLC25A47 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A47 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A47 Gene COMPARTMENTS Subcellular localization image for SLC25A47 gene
Compartment Confidence
mitochondrion 5
extracellular 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC25A47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC25A47: view

Pathways for SLC25A47 Gene

SuperPathways for SLC25A47 Gene

No Data Available

Interacting Proteins for SLC25A47 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354886%0d%0a9606.ENSP00000398495%0d%0a9606.ENSP00000363773%0d%0a
Selected Interacting proteins: ENSP00000354886 for SLC25A47 Gene via STRING

Gene Ontology (GO) - Biological Process for SLC25A47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A47: view

No data available for Pathways by source for SLC25A47 Gene

Transcripts for SLC25A47 Gene

mRNA/cDNA for SLC25A47 Gene

Unigene Clusters for SLC25A47 Gene

Solute carrier family 25, member 47:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A47 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: -
SP2:

Relevant External Links for SLC25A47 Gene

GeneLoc Exon Structure for
SLC25A47
ECgene alternative splicing isoforms for
SLC25A47

Expression for SLC25A47 Gene

mRNA expression in normal human tissues for SLC25A47 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A47 Gene

This gene is overexpressed in Liver (52.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC25A47 Gene

SOURCE GeneReport for Unigene cluster for SLC25A47 Gene Hs.108268

mRNA Expression by UniProt/SwissProt for SLC25A47 Gene

Q6Q0C1-S2547_HUMAN
Tissue specificity: Specifically expressed in liver.
genes like me logo Genes that share expressions with SLC25A47: view

Orthologs for SLC25A47 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A47 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A47 36
  • 98.59 (n)
  • 97.73 (a)
SLC25A47 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC25A47 36
  • 86.1 (n)
  • 86.32 (a)
SLC25A47 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A47 36
  • 87.83 (n)
  • 87.83 (a)
SLC25A47 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a47 36
  • 83.33 (n)
  • 88.31 (a)
Slc25a47 16
Slc25a47 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC25A47 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A47 37
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a47 36
  • 83.23 (n)
  • 87.01 (a)
chicken
(Gallus gallus)
Aves SLC25A47 36
  • 64.58 (n)
  • 63.76 (a)
SLC25A47 37
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC25A47 37
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a47 36
  • 57.55 (n)
  • 61.25 (a)
zebrafish
(Danio rerio)
Actinopterygii slc25a47a 37
  • 54 (a)
OneToMany
slc25a47b 36
  • 58.45 (n)
  • 57.04 (a)
slc25a47b 37
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5646 37
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R07B7.10 37
  • 34 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YMC1 37
  • 28 (a)
ManyToMany
YMC2 37
  • 26 (a)
ManyToMany
Species with no ortholog for SLC25A47:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A47 Gene

ENSEMBL:
Gene Tree for SLC25A47 (if available)
TreeFam:
Gene Tree for SLC25A47 (if available)

Paralogs for SLC25A47 Gene

Paralogs for SLC25A47 Gene

Selected SIMAP similar genes for SLC25A47 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SLC25A47 Gene

genes like me logo Genes that share paralogs with SLC25A47: view

Variants for SLC25A47 Gene

Sequence variations from dbSNP and Humsavar for SLC25A47 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs14233 -- 100,330,153(+) GGGCT(C/T)CCGGC utr-variant-3-prime
rs732898 -- 100,327,789(-) GGCAC(C/T)GCAGG intron-variant
rs1535464 -- 100,327,094(-) gctgt(C/T)ggacc intron-variant
rs1815255 -- 100,326,749(-) tgatc(C/T)gcctg intron-variant
rs1951519 -- 100,326,145(-) GAGAA(G/T)TGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A47 Gene

Variant ID Type Subtype PubMed ID
nsv832875 CNV Loss 17160897

Relevant External Links for SLC25A47 Gene

HapMap Linkage Disequilibrium report
SLC25A47

Disorders for SLC25A47 Gene

(1) MalaCards Diseases for SLC25A47 Gene

Search for SLC25A47 Gene in MalaCards »

Relevant External Links for SLC25A47

Genetic Association Database (GAD)
SLC25A47
Human Genome Epidemiology (HuGE) Navigator
SLC25A47
genes like me logo Genes that share disorders with SLC25A47: view

No data available for UniProtKB/Swiss-Prot for SLC25A47 Gene

Publications for SLC25A47 Gene

  1. Cloning and identification of hepatocellular carcinoma down-regulated mitochondrial carrier protein, a novel liver-specific uncoupling protein. (PMID: 15322095) Tan M.G.K. … Hui K.M. (J. Biol. Chem. 2004) 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S. … Nakagawara A. (Oncogene 2004) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for SLC25A47 Gene

Sources for SLC25A47 Gene

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