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Aliases for SLC25A45 Gene

Aliases for SLC25A45 Gene

  • Solute Carrier Family 25 Member 45 2 3 5
  • Solute Carrier Family 25, Member 45 2

External Ids for SLC25A45 Gene

Previous GeneCards Identifiers for SLC25A45 Gene

  • GC11M064900
  • GC11M065142
  • GC11M061469

Summaries for SLC25A45 Gene

Entrez Gene Summary for SLC25A45 Gene

  • SLC25A45 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC25A45 Gene

SLC25A45 (Solute Carrier Family 25 Member 45) is a Protein Coding gene. An important paralog of this gene is SLC25A47.

Additional gene information for SLC25A45 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A45 Gene

Genomics for SLC25A45 Gene

Regulatory Elements for SLC25A45 Gene

Enhancers for SLC25A45 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H065470 2.7 VISTA FANTOM5 Ensembl ENCODE dbSUPER 14 -106.4 -106383 40 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MCM3 SF1 ZFPL1 POLA2 LOC105369352 SART1 PCNX3 EIF1AD KAT5 SF3B2 MUS81
GH11H065288 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.9 +87.9 87904 14.5 PKNOX1 FOXA2 ATF1 ARID4B SIN3A DMAP1 BRCA1 ZNF766 FOS RUNX3 POLA2 EHD1 LOC728975 SLC25A45 DPF2 FRMD8 ENSG00000255478 SPDYC PGAM1P8 CAPN1
GH11H065438 1.5 Ensembl ENCODE dbSUPER 12.6 -60.5 -60530 10.7 PKNOX1 YY1 TCF12 ZNF121 GLIS2 ZNF143 ZNF207 ATF7 RUNX3 PAF1 NEAT1 SF1 RELA VPS51 EIF1AD FRMD8 SLC25A45 ENSG00000255320 MALAT1 PCNX3
GH11H065510 1.2 ENCODE dbSUPER 12 -127.3 -127285 1.1 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF143 ATF7 RUNX3 MXD4 REST ENSG00000255478 SLC25A45 FRMD8 MIR612 CDC42EP2 EHBP1L1 KCNK7 SNX32 ENSG00000274072 SNRPGP19
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A45 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A45 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for SLC25A45 Gene

Genomic Locations for SLC25A45 Gene
10,649 bases
Minus strand

Genomic View for SLC25A45 Gene

Genes around SLC25A45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A45 Gene

Proteins for SLC25A45 Gene

  • Protein details for SLC25A45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 25 member 45
    Protein Accession:
    Secondary Accessions:
    • Q6PL49
    • Q8IW29

    Protein attributes for SLC25A45 Gene

    288 amino acids
    Molecular mass:
    31906 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A45 Gene


neXtProt entry for SLC25A45 Gene

Post-translational modifications for SLC25A45 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SLC25A45 Gene

Domains & Families for SLC25A45 Gene

Gene Families for SLC25A45 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC25A45 Gene

Suggested Antigen Peptide Sequences for SLC25A45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



S2545_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A45: view

Function for SLC25A45 Gene

Phenotypes From GWAS Catalog for SLC25A45 Gene

Gene Ontology (GO) - Molecular Function for SLC25A45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000064 NOT L-ornithine transmembrane transporter activity IBA --
GO:0022857 transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC25A45: view

Phenotypes for SLC25A45 Gene

genes like me logo Genes that share phenotypes with SLC25A45: view

Animal Model Products

miRNA for SLC25A45 Gene

miRTarBase miRNAs that target SLC25A45

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A45 Gene

Localization for SLC25A45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A45 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A45 gene
Compartment Confidence
mitochondrion 4
extracellular 2
nucleus 2
cytosol 2
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC25A45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with SLC25A45: view

Pathways & Interactions for SLC25A45 Gene

SuperPathways for SLC25A45 Gene

No Data Available

Interacting Proteins for SLC25A45 Gene

Gene Ontology (GO) - Biological Process for SLC25A45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000066 NOT mitochondrial ornithine transport IBA --
GO:0006810 transport IEA --
GO:0006839 mitochondrial transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A45: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A45 Gene

Drugs & Compounds for SLC25A45 Gene

No Compound Related Data Available

Transcripts for SLC25A45 Gene

Unigene Clusters for SLC25A45 Gene

Solute carrier family 25, member 45:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A45 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - - - - - -
SP10: - - - - -

Relevant External Links for SLC25A45 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC25A45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A45 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A45 Gene

This gene is overexpressed in Pancreas (x5.2).

Protein differential expression in normal tissues from HIPED for SLC25A45 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (66.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC25A45 Gene

Protein tissue co-expression partners for SLC25A45 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC25A45 Gene:


SOURCE GeneReport for Unigene cluster for SLC25A45 Gene:


Evidence on tissue expression from TISSUES for SLC25A45 Gene

  • Pancreas(4.3)
genes like me logo Genes that share expression patterns with SLC25A45: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A45 Gene

Orthologs for SLC25A45 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A45 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC25A45 33 34
  • 99.42 (n)
(Bos Taurus)
Mammalia SLC25A45 33 34
  • 88.54 (n)
(Canis familiaris)
Mammalia SLC25A45 33 34
  • 87.85 (n)
(Rattus norvegicus)
Mammalia Slc25a45 33
  • 84.2 (n)
(Mus musculus)
Mammalia Slc25a45 33 16 34
  • 83.16 (n)
(Monodelphis domestica)
Mammalia SLC25A45 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia SLC25A45 34
  • 55 (a)
(Anolis carolinensis)
Reptilia SLC25A45 34
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a45 33
  • 58.39 (n)
(Danio rerio)
Actinopterygii LOC100329446 33
  • 56.55 (n)
si:dkey-150i13.2 34
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5646 34
  • 34 (a)
(Caenorhabditis elegans)
Secernentea R07B7.10 33 34
  • 44.73 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YMC1 34
  • 27 (a)
YMC2 34
  • 25 (a)
Species where no ortholog for SLC25A45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A45 Gene

Gene Tree for SLC25A45 (if available)
Gene Tree for SLC25A45 (if available)

Paralogs for SLC25A45 Gene

Paralogs for SLC25A45 Gene

genes like me logo Genes that share paralogs with SLC25A45: view

Variants for SLC25A45 Gene

Sequence variations from dbSNP and Humsavar for SLC25A45 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000078572 -- 65,378,634(+) ACTTT(G/T)TCCTT intron-variant
rs1000584157 -- 65,374,717(+) AACTC(C/T)AGCTC downstream-variant-500B
rs1000820805 -- 65,377,755(+) AGTGC(A/T)GGGGG intron-variant
rs1000869584 -- 65,383,411(+) GGCTT(A/G)GGCTG upstream-variant-2KB, utr-variant-5-prime
rs1000885325 -- 65,378,852(+) GATGA(C/T)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A45 Gene

Variant ID Type Subtype PubMed ID
nsv951016 CNV deletion 24416366
nsv526181 CNV gain 19592680
esv2422285 CNV deletion 17116639

Variation tolerance for SLC25A45 Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A45 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A45 Gene

Disorders for SLC25A45 Gene

Relevant External Links for SLC25A45

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC25A45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A45 Gene

Publications for SLC25A45 Gene

  1. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T … Fredriksson R (Genomics 2006) 2 3 4 60
  2. Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality. (PMID: 24159190) Seppälä I … AtheroRemo Consortium (European heart journal 2014) 3 60
  3. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F (Molecular aspects of medicine 2013) 3 60
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 60
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60

Products for SLC25A45 Gene

Sources for SLC25A45 Gene

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