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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC25A45 Gene

protein-coding GIFtS: 39
GCID: GC11M065142

solute carrier family 25, member 45

Search for SLC25A45
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 25, Member 45¹ ²
Solute Carrier Family 25 Member 45²

External Ids:	HGNC: 27442¹	Entrez Gene: 283130²	Ensembl: ENSG00000162241⁷	OMIM: 610825⁵	UniProtKB: Q8N413³

Export aliases for SLC25A45 gene to outside databases

Previous GC identifers: GC11M064900 GC11M061469

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC25A45:

SLC25A45 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 (PubMed

16949250)).(supplied by OMIM, Mar 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC25A45 gene promoter:
AREB6 RP58 Sp1 HSF2 Lmo2 CUTL1 HNF-4alpha2 Pax-4a HNF-4alpha1 ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC25A45 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC25A45

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC25A45

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1

SLC25A45 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A45 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M065142: view genomic region (about GC identifiers)

Start:	65,142,663 bp from pter	End:	65,151,172 bp from pter
Size:	8,510 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S2545_HUMAN, Q8N413 (See protein sequence)

Recommended Name: Solute carrier family 25 member 45

Size: 288 amino acids; 31906 Da

Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)

Secondary accessions: Q6PL49 Q8IW29

Alternative splicing: 4 isoforms: Q8N413-1 Q8N413-2 Q8N413-3 Q8N413-4 (No experimental confirmation available. Ref.3 (BC041100) sequence differs from that shown due to a frameshift in position 208)

Explore the universe of human proteins at neXtProt for SLC25A45: NX_Q8N413

SLC25A45 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001070709.1 NP_872362.2

ENSEMBL proteins:

ENSP00000435489 ENSP00000431769 ENSP00000294187 ENSP00000434582 ENSP00000435547

ENSP00000431891 ENSP00000433729 ENSP00000431642 ENSP00000435000 ENSP00000433693

ENSP00000381782 ENSP00000353879 ENSP00000366357 ENSP00000407530

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Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	--	--
GO:0005743	mitochondrial inner membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

SLC25A45 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC25A45 for domains About GeneDecksing

3 InterPro domains/families:

IPR002067 Mit_carrier

IPR023395 Mt_carrier_dom

IPR018108 Mitochondrial_sb/sol_carrier

Graphical View of Domain Structure for InterPro Entry Q8N413

ProtoNet protein and cluster: Q8N413

UniProtKB/Swiss-Prot: S2545_HUMAN, Q8N413

Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family

Similarity: Contains 3 Solcar repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLC25A45

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	--	--
GO:0055085	transmembrane transport	IEA	--

SLC25A45 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for SLC25A45
Search CenterWatch for drugs/clinical trials and news about SLC25A45 / S2545

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for SLC25A45 gene (2 alternative transcripts):

NM_001077241.1 NM_182556.2

Unigene Cluster for SLC25A45:

Solute carrier family 25, member 45

Hs.661604 [show with all ESTs]

Unigene Representative Sequence: BX648573

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000534338 ENST00000527174 ENST00000534028(uc001odq.1) ENST00000294187

ENST00000531791 ENST00000526898 ENST00000526432 ENST00000533629 ENST00000526259

ENST00000530936 ENST00000529962 ENST00000524438 ENST00000525944 ENST00000529431

ENST00000398802(uc001odr.1 uc001ods.1) ENST00000360662 ENST00000377152(uc009yqi.1)

ENST00000417511(uc001odt.1)

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Additional cDNA sequence:

AK090434.1 AK091190.1 AK124022.1 AY597807.1 BC036869.1 BC041100.1 BX648573.1

10 DOTS entries:

DT.40267668 DT.40128182 DT.102823385 DT.100776564 DT.95263042 DT.100000572 DT.120743483 DT.40200180

DT.75140357 DT.99979202

24/60 AceView cDNA sequences (see all 60):

BQ026733 BX356617 AA910933 CR591170 AI336233 AI791600 AL555073 AJ711187

AJ711379 AI733103 BX103628 BU074232 BQ549447 BM695511 BU073431 AK090434

AX746837 BM988060 AY597807 NM_182556 BG179588 AK124022 BI834531 BM919552

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A45 (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	·	2d	·	2e	·	2f	^	3a	·	3b	·	3c	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9a	·	9b
SP1:							-		-		-								-		-		-
SP2:							-		-		-								-
SP3:							-		-		-								-		-
SP4:							-		-		-		-		-		-		-		-		-										-
SP5:							-		-		-						-		-		-		-

ECgene alternative splicing isoforms for SLC25A45

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC25A45 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See SLC25A45 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC25A45

SOURCE GeneReport for Unigene cluster: Hs.661604

SABiosciences Custom PCR Arrays for SLC25A45

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A45 gene from 6/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	SLC25A45⁶	--	61(a)	1 ↔ 1	GL343801.1(109121-111059)
zebrafish (Danio rerio)	Actinopterygii	LOC100329446¹	solute carrier family 25 member 45-like	56.55(n) 57.14(a)		100329446 XM_002662196.1 XP_002662242.1
fruit fly (Drosophila melanogaster)	Insecta	CG5646⁶	--	31(a)	1 → many	3R(23385101-23387041)
worm (Caenorhabditis elegans)	Secernentea	R07B7.10¹	Protein R07B7.10	43.92(n) 37.59(a)		187658 NM_073629.2 NP_506030.2
thale cress (Arabidopsis thaliana)	eudicotyledons	BAC2⁶	Mitochondrial substrate carrier family protein	33(a)	1 → many	1(30052297-30053936)
rice (Oryza sativa)	Liliopsida	--	mitochondrial carrier protein, putative, expressed...	33(a)	1 → many	1(6878905-6880968)

ENSEMBL Gene Tree for SLC25A45 (if available)
TreeFam Gene Tree for SLC25A45 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC25A45 gene

SLC25A2² SLC25A20² SLC25A15² SLC25A48² SLC25A47² SLC25A29²

12 SIMAP similar genes for SLC25A45 using alignment to 6 protein entries: S2545_HUMAN (see all proteins):

FLJ00351 LOC283130 SLC25A48 SLC25A47 SLC25A36 SLC25A15

SLC25A2 SLC25A1 SLC25A29 SLC25A12 SLC25A13 SLC25A20

SLC25A45 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs146814875^1,2		--	65142204(+)	`GAGGCC/GAAGGT`	2	--	ds500¹		0	--	--	--	--
rs35450364^1,2		--	65142360(+)	`TTGAGT/GCCAGG`	2	--	ds500¹		1		NA	2
rs61895442^1,2	C,	--	65142455(+)	`NNNNAG/AAGAAA`	2	--	ds500¹		1		NA	2
rs111556804^1,2	C,	--	65142455(+)	`AATAGAGAAAAA GAAAA/-AGAAA`	2	--	ds500¹		1		CSA	2
rs59129412^1,2	C	--	65142473(+)	`GAAAAAGAAAAA GAAAA/-CAAGC`	2	--	ds500¹		1		NA	2
rs116054942^1,2	F,	--	65142547(+)	`GACCTC/TGAGAA`	2	--	ds500¹		1		WA	118
rs181499379^1,2		--	65142559(+)	`GGTCAC/GAGCAG`	2	--	ds500¹		0	--	--	--	--
rs150129833^1,2		--	65142598(+)	`AAGCTA/GTGTGG`	2	--	ds500¹		0	--	--	--	--
rs185987889^1,2		--	65142804(+)	`AGAAGC/TGCAGG`	2	--	ut3¹		0	--	--	--	--
rs114876907^1,2	F,	--	65142924(+)	`GGTCTC/TGGAGG`	2	--	ut3¹		1		WA	118

HapMap Linkage Disequilibrium report for SLC25A45 (65142663 - 65151172 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SLC25A45
1 CNV: 5423

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC25A45 for disorders About MalaCards

SLC25A45 for disorders About GeneDecksing

OMIM gene information: 610825 OMIM disorders: --

Export disorders for SLC25A45 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLC25A45 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC25A45)

Utopia: connect your pdf to the dynamic
world of online information

Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PubMed id 16949250)^{1, 2, 3} Haitina T.... Fredriksson R. (2006)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)² Taylor T.D....Sakaki Y. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 283130	HGNC: 27442	AceView: LOC283130	Ensembl:ENSG00000162241	euGenes: HUgn283130
ECgene: SLC25A45	H-InvDB: SLC25A45

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLC25A45	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC25A45 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SLC25A45 gene:
Search GeneIP for patents involving SLC25A45

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
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About This Section


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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC25A45
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	GenScript Custom Purified and Recombinant Proteins Services for SLC25A45		GenScript cDNA clones with any tag delivered in your preferred vector for SLC25A45
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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SLC25A45 Gene

solute carrier family 25, member 45

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SLC25A45 Gene

solute carrier family 25, member 45

Aliasesfor SLC25A45 gene

Summariesfor SLC25A45 gene

Genomic Viewsfor SLC25A45 gene

Proteinsfor SLC25A45 gene

Protein Domains /Familiesfor SLC25A45 gene

Functionfor SLC25A45 gene

Pathways & Interactionsfor SLC25A45 gene

Drugs & Compoundsfor SLC25A45 gene

Transcriptsfor SLC25A45 gene

Expression for SLC25A45 gene

Orthologsfor SLC25A45 gene

Paralogsfor SLC25A45 gene

Genomic Variantsfor SLC25A45 gene

Disorders / Diseasesfor SLC25A45 gene

Publicationsfor SLC25A45 gene

External Searches for SLC25A45 gene

Genome Databases showing SLC25A45 gene

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Specialized Databases showing SLC25A45 gene

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Productsfor SLC25A45 gene

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Aliases
for SLC25A45 gene

Summaries
for SLC25A45 gene

Genomic Views
for SLC25A45 gene

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for SLC25A45 gene

Protein Domains /
Families
for SLC25A45 gene

Function
for SLC25A45 gene

Pathways & Interactions
for SLC25A45 gene

Drugs & Compounds
for SLC25A45 gene

Transcripts
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Expression
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Orthologs
for SLC25A45 gene

Paralogs
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for SLC25A45 gene

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for SLC25A45 gene

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for SLC25A45 gene