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SLC25A45 Gene

protein-coding   GIFtS: 43
GCID: GC11M065142

Solute Carrier Family 25, Member 45

  Search for SLC25A45
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 25, Member 451 2
Solute Carrier Family 25 Member 452

External Ids:    HGNC: 274421   Entrez Gene: 2831302   Ensembl: ENSG000001622417   OMIM: 6108255   UniProtKB: Q8N4133   

Export aliases for SLC25A45 gene to outside databases

Previous GC identifers: GC11M064900 GC11M061469


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC25A45 Gene:
SLC25A45 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 (PubMed
16949250)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SLC25A45 Gene:
SLC25A45 (solute carrier family 25, member 45) is a protein-coding gene. An important paralog of this gene is SLC25A20.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC25A45 gene promoter:
         AREB6   RP58   Sp1   HSF2   Lmo2   CUTL1   HNF-4alpha2   Pax-4a   HNF-4alpha1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC25A45 promoter sequence
   Search Chromatin IP Primers for SLC25A45

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC25A45


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

SLC25A45 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A45 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M065142:  view genomic region     (about GC identifiers)

Start:
65,142,663 bp from pter      End:
65,151,172 bp from pter
Size:
8,510 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S2545_HUMAN, Q8N413 (See protein sequence)
Recommended Name: Solute carrier family 25 member 45  
Size: 288 amino acids; 31906 Da
Secondary accessions: Q6PL49 Q8IW29
Alternative splicing: 4 isoforms:  Q8N413-1   Q8N413-2   Q8N413-3   Q8N413-4   (No experimental confirmation available. Ref.3 (BC041100) sequence differs from that shown due to a frameshift in position 208)

Explore the universe of human proteins at neXtProt for SLC25A45: NX_Q8N413

Explore proteomics data for SLC25A45 at MOPED


See SLC25A45 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (4 alternative transcripts): 
NP_001070709.1  NP_001265179.1  NP_001265180.1  NP_872362.2  

ENSEMBL proteins: 
 ENSP00000435489   ENSP00000431769   ENSP00000294187   ENSP00000434582   ENSP00000435547  
 ENSP00000431891   ENSP00000433729   ENSP00000431642   ENSP00000435000   ENSP00000433693  
 ENSP00000381782   ENSP00000353879   ENSP00000366357   ENSP00000407530  

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Cloud-Clone Corp. Proteins for SLC25A45

 
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LSBio Antibodies in human, mouse, rat for SLC25A45

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Search eBioscience for ELISAs for SLC25A45 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SLC: Solute carriers

IUPHAR Guide to PHARMACOLOGY protein family classification: SLC25A45
Miscellaneous SLC25 mitochondrial transporters

3 InterPro protein domains:
 IPR002067 Mit_carrier
 IPR023395 Mt_carrier_dom
 IPR018108 Mitochondrial_sb/sol_carrier

Graphical View of Domain Structure for InterPro Entry Q8N413

ProtoNet protein and cluster: Q8N413

UniProtKB/Swiss-Prot: S2545_HUMAN, Q8N413
Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
Similarity: Contains 3 Solcar repeats


Find genes that share domains with SLC25A45           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC25A45
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miRNA
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hsa-miR-1226
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Inhib. RNA
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GenScript: all cDNA clones in your preferred vector (see all 2): SLC25A45 (NM_182556)
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
S2545_HUMAN, Q8N413: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
extracellular2
cytosol1
endoplasmic reticulum1
lysosome1
nucleus1
peroxisome1
plasma membrane1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion ----
GO:0005743mitochondrial inner membrane IEA--
GO:0016021integral component of membrane IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC25A45
Interactions:

    Search GeneGlobe Interaction Network for SLC25A45

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for SLC25A45 (ENSP000003817824) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
RBM25ENSP000002619734STRING: ENSP00000261973
ARGLU1ENSP000003830594STRING: ENSP00000383059
PRPF40BENSP000003696344STRING: ENSP00000369634
--ENSP000004020944STRING: ENSP00000402094
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006810transport ----
GO:0055085transmembrane transport IEA--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SLC25A45 (S2545)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SLC25A45 gene (4 alternative transcripts): 
NM_001077241.1  NM_001278250.1  NM_001278251.1  NM_182556.2  

Unigene Cluster for SLC25A45:

Solute carrier family 25, member 45
Hs.661604  [show with all ESTs]
Unigene Representative Sequence: BX648573
18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000534338 ENST00000527174 ENST00000534028(uc001odq.1) ENST00000294187
ENST00000531791 ENST00000526898 ENST00000526432 ENST00000533629 ENST00000526259
ENST00000530936 ENST00000529962 ENST00000524438 ENST00000525944 ENST00000529431
ENST00000398802(uc001odr.1 uc001ods.1) ENST00000360662 ENST00000377152(uc009yqi.1)
ENST00000417511(uc001odt.1)
miRNA
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1 qRT-PCR Assays for microRNA that regulate SLC25A45:
hsa-miR-1226
SwitchGear 3'UTR luciferase reporter plasmidSLC25A45 3' UTR sequence
Inhib. RNA
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Primer
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  QuantiFast Probe-based Assays in human, mouse, rat SLC25A45

Additional mRNA sequence: 

AK090434.1 AK091190.1 AK124022.1 AY597807.1 BC036869.1 BC041100.1 BX648573.1 

10 DOTS entries:

DT.40267668  DT.40128182  DT.102823385  DT.100776564  DT.95263042  DT.100000572  DT.120743483  DT.40200180 
DT.75140357  DT.99979202 

Selected AceView cDNA sequences (see all 60):

CR591170 BX356617 AI733103 AI791600 BU073431 AJ711187 AI336233 AJ711379 
BQ026733 BU074232 AA910933 AL555073 BM695511 BQ549447 BX103628 AX746837 
BM919552 AW135342 BC036869 BX648573 BG392502 BM988060 BX471029 AI042326 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A45 (see all 10)    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1:                    -     -     -                       -     -     -                                                         
SP2:                    -     -     -                       -                                                                     
SP3:                    -     -     -                       -     -                                                               
SP4:                    -     -     -     -     -     -     -     -     -                             -                           
SP5:                    -     -     -                 -     -     -     -                                                         


ECgene alternative splicing isoforms for SLC25A45

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SLC25A45 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
SLC25A45 Expression
About this image


SLC25A45 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Thymus (Hematopoietic System)
         Thymus
SLC25A45 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SLC25A45 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.661604
    Custom PCR Arrays for SLC25A45
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A45

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A45 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Slc25a451 , 5 solute carrier family 25, member 451, 5 83.16(n)1
85.37(a)1
  19 (4.34 cM)5
1073751  NM_134154.31  NP_598915.11 
 58778085 
lizard
(Anolis carolinensis)
Reptilia SLC25A456
solute carrier family 25, member 45
62(a)
1 ↔ 1
GL343801.1(109121-111059)
tropical clawed frog
(Xenopus tropicalis)
Amphibia slc25a451 solute carrier family 25, member 45 58.39(n)
62.06(a)
  100127755  NM_001113089.2  NP_001106560.1 
zebrafish
(Danio rerio)
Actinopterygii LOC1003294461 solute carrier family 25 member 45-like 56.55(n)
57.14(a)
  100329446  XM_002662196.2  XP_002662242.1 
fruit fly
(Drosophila melanogaster)
Insecta CG56466
--
34(a)
1 → many
3R(23385101-23387041)
worm
(Caenorhabditis elegans)
Secernentea R07B7.101 R07B7.10 44.73(n)
38.97(a)
  187658  NM_073629.2  NP_506030.2 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YMC16
YMC26
Mitochondrial protein, putative inner membrane tra...
Mitochondrial protein, putative inner membrane tra...
27(a)
25(a)
many ↔ many
many ↔ many
XVI(673751-674674) YPR058W
II(449667-450656) YBR104W


ENSEMBL Gene Tree for SLC25A45 (if available)
TreeFam Gene Tree for SLC25A45 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SLC25A45 gene
SLC25A202  SLC25A482  SLC25A472  SLC25A292  
13 SIMAP similar genes for SLC25A45 using alignment to 6 protein entries:     S2545_HUMAN (see all proteins):
FLJ00351    LOC283130    SLC25A48    SLC25A47    SLC25A36    SLC25A23
SLC25A15    SLC25A2    SLC25A1    SLC25A29    SLC25A12    SLC25A13
SLC25A20

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SLC25A45 (see all 272)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1468148751,2
--65142204(+) GAGGCC/GAAGGT 2 -- ds50010--------
rs354503641,2
F--65142360(+) TTGAGG/TCCAGG 2 -- ds50012Minor allele frequency- T:0.50NA 4
rs618954421,2
C--65142455(+) AAATAG/AAGAAA 2 -- ds50011Minor allele frequency- A:0.50NA 2
rs671761831,2
C--65142456(+) ATAGA-/AGAAA 
 AAGAAAA
GAAAA
2 -- cds10--------
rs591294121,2
C--65142461(+) GAAAAAGAAAAA 
 GAAAA
/-
CAAGC
2 -- cds11Minor allele frequency- -:0.00NA 2
rs1160549421,2
F--65142547(+) GACCTC/TGAGAA 2 -- ds50011Minor allele frequency- T:0.06WA 118
rs1814993791,2
--65142559(+) GGTCAC/GAGCAG 2 -- ds50010--------
rs1501298331,2
C--65142598(+) AAGCTA/GTGTGG 2 -- ds50010--------
rs1859878891,2
--65142804(+) AGAAGC/TGCAGG 2 -- ut310--------
rs1148769071,2
C,F--65142924(+) GGTCTC/TGGAGG 2 -- ut311Minor allele frequency- T:0.09WA 118

HapMap Linkage Disequilibrium report for SLC25A45 (65142663 - 65151172 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for SLC25A45:    About this table    
Variant IDTypeSubtypePubMed ID
esv2422285CNV Deletion17116639
nsv897717CNV Loss21882294
dgv1175n71CNV Loss21882294
nsv897718CNV Loss21882294
nsv526181CNV Gain19592680

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SLC25A45
DNA2.0 Custom Variant and Variant Library Synthesis for SLC25A45

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 610825    OMIM disorders: --


Find genes that share disorders with SLC25A45           About GenesLikeMe


Export disorders for SLC25A45 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SLC25A45 gene integrated from 10 sources:
(articles sorted by number of sources associating them with SLC25A45)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PubMed id 16949250)1, 2, 3 Haitina T.... Fredriksson R. (Genomics 2006)
  2. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PubMed id 23266187)1 Palmieri F. (Mol. Aspects Med. 2013)
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
  10. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 283130 HGNC: 27442 AceView: LOC283130 Ensembl:ENSG00000162241 euGenes: HUgn283130
ECgene: SLC25A45 H-InvDB: SLC25A45

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SLC25A45 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SLC25A45 gene:
Search GeneIP for patents involving SLC25A45

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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