Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC25A45 Gene

Aliases for SLC25A45 Gene

  • Solute Carrier Family 25 Member 45 2 3 5
  • Solute Carrier Family 25, Member 45 2

External Ids for SLC25A45 Gene

Previous GeneCards Identifiers for SLC25A45 Gene

  • GC11M064900
  • GC11M065142
  • GC11M061469

Summaries for SLC25A45 Gene

Entrez Gene Summary for SLC25A45 Gene

  • SLC25A45 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC25A45 Gene

SLC25A45 (Solute Carrier Family 25 Member 45) is a Protein Coding gene. An important paralog of this gene is SLC25A47.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A45 Gene

Genomics for SLC25A45 Gene

Regulatory Elements for SLC25A45 Gene

Enhancers for SLC25A45 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F065470 2.5 VISTA FANTOM5 Ensembl ENCODE 14 -106.4 -106383 40.0 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 LOC105369353 LOC105369352 KAT5 SSSCA1-AS1 NEAT1 ZFPL1 EIF1AD EHBP1L1 MRPL11 POLA2
GH11F065288 1.7 FANTOM5 Ensembl ENCODE 12.9 +87.9 87904 14.5 HDGF PKNOX1 ARID4B DMAP1 YY1 SLC30A9 FOS ZNF263 SP5 JUNB POLA2 EHD1 LOC728975 SLC25A45 DPF2 FRMD8 ENSG00000255478 SPDYC CAPN1 PGAM1P8
GH11F065452 1 ENCODE 12.6 -71.3 -71327 5.2 HDGF ATF1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A ZNF48 ZNF143 FOS NEAT1 FRMD8 EIF1AD KAT5 POLA2 ZFPL1 PCNX3 SLC25A45 MALAT1 ENSG00000255478
GH11F065438 1 ENCODE 12.6 -60.5 -60530 10.7 PKNOX1 SIN3A YY1 ZNF121 GLIS2 ZNF207 PAF1 ZNF263 TBX21 SSRP1 NEAT1 FRMD8 SLC25A45 MALAT1 ENSG00000255478 TIGD3 CDC42EP2 LOC101927789 LOC728975 BANF1
GH11F065650 1.9 FANTOM5 Ensembl ENCODE 6.1 -269.7 -269662 6.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 LOC105369352 RNASEH2C ZFPL1 KAT5 RBM14 MRPL11 LOC105369353 EIF1AD MUS81 MAP3K11
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A45 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A45 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000563801 1301 1201 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for SLC25A45 Gene

Chromosome:
11
Start:
65,373,053 bp from pter
End:
65,383,701 bp from pter
Size:
10,649 bases
Orientation:
Minus strand

Genomic View for SLC25A45 Gene

Genes around SLC25A45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A45 Gene

Proteins for SLC25A45 Gene

  • Protein details for SLC25A45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N413-S2545_HUMAN
    Recommended name:
    Solute carrier family 25 member 45
    Protein Accession:
    Q8N413
    Secondary Accessions:
    • Q6PL49
    • Q8IW29

    Protein attributes for SLC25A45 Gene

    Size:
    288 amino acids
    Molecular mass:
    31906 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A45 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A45 Gene

Post-translational modifications for SLC25A45 Gene

No Post-translational modifications

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SLC25A45

No data available for DME Specific Peptides for SLC25A45 Gene

Domains & Families for SLC25A45 Gene

Gene Families for SLC25A45 Gene

Protein Domains for SLC25A45 Gene

Suggested Antigen Peptide Sequences for SLC25A45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N413

UniProtKB/Swiss-Prot:

S2545_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A45: view

Function for SLC25A45 Gene

Phenotypes for SLC25A45 Gene

genes like me logo Genes that share phenotypes with SLC25A45: view

Animal Model Products

miRNA for SLC25A45 Gene

miRTarBase miRNAs that target SLC25A45

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A45 Gene

Localization for SLC25A45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A45 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A45 gene
Compartment Confidence
mitochondrion 4
extracellular 2
nucleus 2
cytosol 2
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SLC25A45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC25A45: view

Pathways & Interactions for SLC25A45 Gene

SuperPathways for SLC25A45 Gene

No Data Available

Interacting Proteins for SLC25A45 Gene

Gene Ontology (GO) - Biological Process for SLC25A45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A45: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A45 Gene

Transcripts for SLC25A45 Gene

Unigene Clusters for SLC25A45 Gene

Solute carrier family 25, member 45:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A45 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - - - - - -
SP9:
SP10: - - - - -

Relevant External Links for SLC25A45 Gene

GeneLoc Exon Structure for
SLC25A45
ECgene alternative splicing isoforms for
SLC25A45

Expression for SLC25A45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC25A45 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A45 Gene

This gene is overexpressed in Pancreas (x5.2).

Protein differential expression in normal tissues from HIPED for SLC25A45 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (66.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC25A45 Gene



Protein tissue co-expression partners for SLC25A45 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC25A45 Gene:

SLC25A45

SOURCE GeneReport for Unigene cluster for SLC25A45 Gene:

Hs.661604
genes like me logo Genes that share expression patterns with SLC25A45: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SLC25A45 Gene

Orthologs for SLC25A45 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A45 34 35
  • 99.42 (n)
cow
(Bos Taurus)
Mammalia SLC25A45 34 35
  • 88.54 (n)
dog
(Canis familiaris)
Mammalia SLC25A45 34 35
  • 87.85 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a45 34
  • 84.2 (n)
mouse
(Mus musculus)
Mammalia Slc25a45 34 16 35
  • 83.16 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC25A45 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A45 35
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC25A45 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a45 34
  • 58.39 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100329446 34
  • 56.55 (n)
si:dkey-150i13.2 35
  • 33 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5646 35
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R07B7.10 34 35
  • 44.73 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YMC1 35
  • 27 (a)
ManyToMany
YMC2 35
  • 25 (a)
ManyToMany
Species where no ortholog for SLC25A45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A45 Gene

ENSEMBL:
Gene Tree for SLC25A45 (if available)
TreeFam:
Gene Tree for SLC25A45 (if available)

Paralogs for SLC25A45 Gene

Paralogs for SLC25A45 Gene

genes like me logo Genes that share paralogs with SLC25A45: view

Variants for SLC25A45 Gene

Sequence variations from dbSNP and Humsavar for SLC25A45 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111381584 -- 65,381,351(+) GTCTC(A/G)AAATC intron-variant, utr-variant-5-prime
rs111556804 -- 65,374,984(+) AATAG(-/AGAAAAAGAAAA)AGAAA downstream-variant-500B
rs112246159 -- 65,382,062(+) CTGGC(A/G)GGAAG intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs112530419 -- 65,383,766(+) AAAAA(A/C)AAACA upstream-variant-2KB
rs113478243 -- 65,381,291(+) GCGCC(G/T)GGCTA intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC25A45 Gene

Variant ID Type Subtype PubMed ID
nsv951016 CNV deletion 24416366
nsv526181 CNV gain 19592680
esv2422285 CNV deletion 17116639

Variation tolerance for SLC25A45 Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A45 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A45 Gene

Disorders for SLC25A45 Gene

Relevant External Links for SLC25A45

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A45

No disorders were found for SLC25A45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A45 Gene

Publications for SLC25A45 Gene

  1. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T. … Fredriksson R. (Genomics 2006) 2 3 4 64
  2. Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality. (PMID: 24159190) SeppAolAo I. … LehtimAoki T. (Eur. Heart J. 2014) 3 64
  3. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F. (Mol. Aspects Med. 2013) 3 64
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for SLC25A45 Gene

Sources for SLC25A45 Gene

Content
Loading form....