SLC25A44 Gene
protein-coding GIFtS: 43
GCID: GC01P156163
|
|
solute carrier family 25, member 44
| |
Aliases for SLC25A44 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Solute Carrier Family 25, Member 441 2 | | KIAA04461 3 | | FLJ904311 | | RP11-54H19.32 | | Solute Carrier Family 25 Member 442 |
Export aliases for SLC25A44 gene to outside databasesPrevious GC identifers: GC01P154432 GC01P127525 |
Summaries for SLC25A44 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for SLC25A44: SLC25A44 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 (PubMed16949250)).(supplied by OMIM, Mar 2008)
|
Genomic Views for SLC25A44 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SLC25A44 gene promoter: GR TBP GR-beta NF-kappaB MZF-1 HOXA5 GR-alpha NF-kappaB1 Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC25A44
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC25A44 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q22 Ensembl cytogenetic band: 1q22 HGNC cytogenetic band: 1q22SLC25A44 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P156163: view genomic region
(about GC identifiers)
Start:
|
156,163,730 bp from pter |
End:
|
156,182,587 bp from pter |
Size:
|
18,858 bases |
Orientation:
|
plus strand |
|
Proteins for SLC25A44 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: S2544_HUMAN, Q96H78 (See
protein sequence)Recommended Name: Solute carrier family 25 member 44 Size: 314 amino acids; 35392 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
Sequence caution: Sequence=BAA32291.3; Type=Erroneous initiation;
Secondary accessions: O75034Explore the universe of human proteins at neXtProt for SLC25A44: NX_Q96H78
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96H78 SLC25A44 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055470.1 ENSEMBL proteins: ENSP00000352497 ENSP00000407560 Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SLC25A44 for ontologies About GeneDecksing
SLC25A44 Antibody Products: Assay Products for SLC25A44: |
Protein
Domains / Families for SLC25A44 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC25A44 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96H78ProtoNet protein and cluster: Q96H78 UniProtKB/Swiss-Prot: S2544_HUMAN, Q96H78Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) familySimilarity: Contains 3 Solcar repeats |
Function for SLC25A44 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A44 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A44 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SLC25A44 (NM_014655) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC25A44 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A44  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A44 |
|
Pathways & Interactions for SLC25A44 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC25A44
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
 1 Interacting protein for SLC25A44 (ENSP000003524974) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0055085 | transmembrane transport |
IEA | -- |
SLC25A44 for ontologies About GeneDecksing
|
Drugs & Compounds for SLC25A44 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for SLC25A44 Search CenterWatch for drugs/clinical trials and news about SLC25A44 / S2544 
|
Transcripts for SLC25A44 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for SLC25A44 gene (2 alternative transcripts): NM_001135672.1 NM_014655.2 Unigene Cluster for SLC25A44: Solute carrier family 25, member 44 Hs.532375 [show with all ESTs]Unigene Representative Sequence: NM_0146555 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000359511(uc001fnp.3 uc010phc.2 uc009wrr.3 uc010phd.2 uc010phe.2) ENST00000468973 ENST00000469537 ENST00000482737 ENST00000423538
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A44 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A44 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SLC25A44 (NM_014655) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC25A44 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A44  |
Additional cDNA sequence: AB007915.3 AK074912.1 AK075002.1 AK294524.1 AK299747.1 AK307968.1 AK309678.1 AK309690.1 BC008843.2 BC039854.1 12 DOTS entries: DT.454121 DT.97808672 DT.97791124 DT.95275481 DT.121447195 DT.121447165 DT.121447207 DT.95300465 DT.97816588 DT.121447185 DT.91859428 DT.99964751 24/177 AceView cDNA sequences (see all 177): Z40122 BM789708 CB132068 BQ061737 CA390338 AA829384 CA311183 BM758134 BM930292 BE350843 BM450095 AA907452 BM787428 BC008843 AA262172 BQ225679 BQ431708 AK075002 AI801142 CD369249 AL135509 BM828456 NM_014655 AA416723 GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A44 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e | |
| SP1: | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for SLC25A44
|
Expression for SLC25A44 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC25A44 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GCACAGTGGG
About this image See SLC25A44 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SLC25A44
SOURCE GeneReport for Unigene cluster: Hs.532375 SABiosciences Custom PCR Arrays for SLC25A44
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC25A44 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC25A44 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC25A44 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC25A44 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A44 |
Orthologs for SLC25A44 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC25A44 gene from 6/25 species (see all 25) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
African clawed frog (Xenopus laevis) |
Amphibia |
Xl.35952 |
Xenopus laevis transcribed sequence with weak similarity more |
78.47(n) |
  |
CA987354.1 |
zebrafish (Danio rerio) |
Actinopterygii |
Dr.268702 |
Transcribed sequence with weak similarity to protein more |
77.12(n) |
  |
57073724 |
fruit fly (Drosophila melanogaster) |
Insecta |
CG58051 |
CG5805 |
52.27(n) 39.94(a) |
  |
42950 NM_143027.3 NP_651284.1 |
worm (Caenorhabditis elegans) |
Secernentea |
F13G3.71 |
Protein F13G3.7 |
46.49(n) 34.87(a) |
  |
172478 NM_001025932.2 NP_001021103.1 |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
AT5G156401 |
Mitochondrial substrate carrier family protein |
46.52(n) 37.41(a) |
  |
831418 NM_121568.2 NP_568317.1 |
rice (Oryza sativa) |
Liliopsida |
Os03g07548001 |
hypothetical protein |
49.24(n) 40.35(a) |
  |
4334148 NM_001057843.1 NP_001051308.1 |
ENSEMBL Gene Tree for SLC25A44 (if available) TreeFam Gene Tree for SLC25A44 (if available)  |
Paralogs for SLC25A44 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for SLC25A44 gene
- SLC25A132 SLC25A122 SLC25A182 SLC25A222
SLC25A44 for paralogs About GeneDecksing
|
Genomic Variants for SLC25A44 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 1 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC25A44 (156163730 - 156182587 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for SLC25A44: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC25A44 |
|
Disorders
/ Diseases for SLC25A44 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC25A44 for disorders About MalaCards
SLC25A44 for disorders About GeneDecksing
OMIM gene information: 610824
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: SLC25A44 (1 document) Export disorders for SLC25A44 gene to outside databases
|
Publications for SLC25A44 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC25A44 gene integrated from 9 sources: (articles sorted by number of sources associating them with SLC25A44) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PubMed id 16949250)1, 2, 3 Haitina T.... Fredriksson R. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2 Seki N.... Ohara O. (1997)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SLC25A44 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SLC25A44 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC25A44 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing SLC25A44 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for SLC25A44 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC25A44 gene: Search GeneIP for patents involving SLC25A44
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for SLC25A44 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC25A44 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC25A44 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC25A44 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC25A44 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC25A44 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC25A44 |
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 | | SLC25A44 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A44 |
|  |  |  | | | Search ThermoFisher Antibodies for SLC25A44 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A44 |
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