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Aliases for SLC25A44 Gene

Aliases for SLC25A44 Gene

  • Solute Carrier Family 25 Member 44 2 3 5
  • Solute Carrier Family 25, Member 44 2
  • KIAA0446 4

External Ids for SLC25A44 Gene

Previous GeneCards Identifiers for SLC25A44 Gene

  • GC01P154432
  • GC01P127525

Summaries for SLC25A44 Gene

Entrez Gene Summary for SLC25A44 Gene

  • SLC25A44 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC25A44 Gene

SLC25A44 (Solute Carrier Family 25 Member 44) is a Protein Coding gene. An important paralog of this gene is SLC25A13.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A44 Gene

Genomics for SLC25A44 Gene

Regulatory Elements for SLC25A44 Gene

Promoters for SLC25A44 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC25A44 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A44 Gene

Chromosome:
1
Start:
156,193,932 bp from pter
End:
156,212,796 bp from pter
Size:
18,865 bases
Orientation:
Plus strand

Genomic View for SLC25A44 Gene

Genes around SLC25A44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A44 Gene

Proteins for SLC25A44 Gene

  • Protein details for SLC25A44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96H78-S2544_HUMAN
    Recommended name:
    Solute carrier family 25 member 44
    Protein Accession:
    Q96H78
    Secondary Accessions:
    • O75034

    Protein attributes for SLC25A44 Gene

    Size:
    314 amino acids
    Molecular mass:
    35392 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA32291.3; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC25A44 Gene

Proteomics data for SLC25A44 Gene at MOPED

Post-translational modifications for SLC25A44 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A44 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC25A44 Gene

Domains & Families for SLC25A44 Gene

Gene Families for SLC25A44 Gene

Protein Domains for SLC25A44 Gene

Graphical View of Domain Structure for InterPro Entry

Q96H78

UniProtKB/Swiss-Prot:

S2544_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A44: view

Function for SLC25A44 Gene

genes like me logo Genes that share phenotypes with SLC25A44: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A44

CRISPR Products

miRNA for SLC25A44 Gene

miRTarBase miRNAs that target SLC25A44

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A44 Gene

Localization for SLC25A44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A44 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A44 Gene COMPARTMENTS Subcellular localization image for SLC25A44 gene
Compartment Confidence
cytoskeleton 3
mitochondrion 3
peroxisome 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC25A44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with SLC25A44: view

Pathways & Interactions for SLC25A44 Gene

SuperPathways for SLC25A44 Gene

No Data Available

Interacting Proteins for SLC25A44 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000352497%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000352497 for SLC25A44 Gene via STRING

Symbol External ID(s) Details
ELAVL1

Gene Ontology (GO) - Biological Process for SLC25A44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A44: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A44 Gene

Drugs & Compounds for SLC25A44 Gene

No Compound Related Data Available

Transcripts for SLC25A44 Gene

Unigene Clusters for SLC25A44 Gene

Solute carrier family 25, member 44:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A44 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - - - - - - - -
SP5:
SP6: -
SP7: - - - - - - - - - - -
SP8: - -
SP9:
SP10: - -

Relevant External Links for SLC25A44 Gene

GeneLoc Exon Structure for
SLC25A44
ECgene alternative splicing isoforms for
SLC25A44

Expression for SLC25A44 Gene

mRNA expression in normal human tissues for SLC25A44 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A44 Gene

This gene is overexpressed in Whole Blood (x6.1).

Protein differential expression in normal tissues from HIPED for SLC25A44 Gene

This gene is overexpressed in Plasma (62.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A44 Gene



SOURCE GeneReport for Unigene cluster for SLC25A44 Gene Hs.532375

genes like me logo Genes that share expression patterns with SLC25A44: view

Protein tissue co-expression partners for SLC25A44 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLC25A44 Gene

Orthologs for SLC25A44 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A44 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC25A44 35
  • 92.99 (n)
  • 98.73 (a)
SLC25A44 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A44 35
  • 92.14 (n)
  • 97.13 (a)
SLC25A44 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a44 35
  • 90.02 (n)
  • 96.18 (a)
Slc25a44 16
Slc25a44 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC25A44 35
  • 100 (n)
  • 100 (a)
SLC25A44 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a44 35
  • 90.13 (n)
  • 96.18 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC25A44 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a44 35
  • 76.36 (n)
  • 85.62 (a)
Str.7069 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3595 35
zebrafish
(Danio rerio)
Actinopterygii Dr.26870 35
slc25a44b 35
  • 70.06 (n)
  • 75.48 (a)
slc25a44a 36
  • 71 (a)
OneToMany
slc25a44b 36
  • 75 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3005 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003208 35
  • 51.69 (n)
  • 42.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5805 35
  • 52.18 (n)
  • 39.62 (a)
CG5805 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F13G3.7 35
  • 46.62 (n)
  • 35.37 (a)
F13G3.7 36
  • 27 (a)
OneToMany
Y43C5B.3 36
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AGC1 36
  • 8 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G15640 35
  • 46.34 (n)
  • 37.23 (a)
rice
(Oryza sativa)
Liliopsida Os03g0754800 35
  • 49.2 (n)
  • 40.34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToOne
Species with no ortholog for SLC25A44:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A44 Gene

ENSEMBL:
Gene Tree for SLC25A44 (if available)
TreeFam:
Gene Tree for SLC25A44 (if available)

Paralogs for SLC25A44 Gene

Paralogs for SLC25A44 Gene

genes like me logo Genes that share paralogs with SLC25A44: view

Variants for SLC25A44 Gene

Sequence variations from dbSNP and Humsavar for SLC25A44 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11576750 - 156,200,002(+) GAAGA(G/T)CCTCT intron-variant, reference, missense
rs2072499 -- 156,199,819(-) AGCAG(C/T)ATGGA intron-variant
rs2266514 -- 156,203,894(+) agaga(C/T)ggggt intron-variant
rs2253677 -- 156,201,505(-) GGCAT(C/G)AAAAT intron-variant
rs2253809 -- 156,202,334(-) AACGC(A/G)AGTTG intron-variant

Variation tolerance for SLC25A44 Gene

Residual Variation Intolerance Score: 37.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A44 Gene

HapMap Linkage Disequilibrium report
SLC25A44

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC25A44 Gene

Disorders for SLC25A44 Gene

Relevant External Links for SLC25A44

Genetic Association Database (GAD)
SLC25A44
Human Genome Epidemiology (HuGE) Navigator
SLC25A44
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A44

No disorders were found for SLC25A44 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A44 Gene

Publications for SLC25A44 Gene

  1. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T. … Fredriksson R. (Genomics 2006) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage. (PMID: 24656865) Woo D. … Rosand J. (Am. J. Hum. Genet. 2014) 3
  4. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F. (Mol. Aspects Med. 2013) 3
  5. Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14. (PMID: 23666240) Ruark E. … Turnbull C. (Nat. Genet. 2013) 3

Products for SLC25A44 Gene

Sources for SLC25A44 Gene

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