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Aliases for SLC25A44 Gene

Aliases for SLC25A44 Gene

  • Solute Carrier Family 25 Member 44 2 3 5
  • Solute Carrier Family 25, Member 44 2
  • KIAA0446 4

External Ids for SLC25A44 Gene

Previous GeneCards Identifiers for SLC25A44 Gene

  • GC01P154432
  • GC01P127525

Summaries for SLC25A44 Gene

Entrez Gene Summary for SLC25A44 Gene

  • SLC25A44 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC25A44 Gene

SLC25A44 (Solute Carrier Family 25 Member 44) is a Protein Coding gene. An important paralog of this gene is SLC25A13.

Additional gene information for SLC25A44 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A44 Gene

Genomics for SLC25A44 Gene

Regulatory Elements for SLC25A44 Gene

Enhancers for SLC25A44 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H156145 1.9 FANTOM5 Ensembl ENCODE dbSUPER 16.8 -44.6 -44579 7.7 HDGF PKNOX1 ARNT SIN3A ARID4B FEZF1 DMAP1 ZNF2 YY1 SLC30A9 SLC25A44 ENSG00000252236 LMNA MEX3A BGLAP PAQR6 TSACC CCT3 SMG5 ARHGEF2
GH01H156225 1.3 Ensembl ENCODE 21.6 +31.8 31828 0.7 HDGF FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ELK1 SLC25A44 SEMA4A ENSG00000252236 LMNA MEX3A GLMP UBQLN4 LAMTOR2 PMF1 BGLAP
GH01H156281 1.8 FANTOM5 ENCODE dbSUPER 12.5 +89.3 89326 4.4 MLX ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC PPARGC1A MEF2D SSRP1 GLMP SMG5 SLC25A44 PAQR6 BGLAP GON4L DAP3 ENSG00000252236 SEMA4A YY1AP1
GH01H156226 0.8 dbSUPER 21.2 +32.7 32677 1 PKNOX1 BACH1 BMI1 BATF RELA EED ATF7 ZSCAN29 ETV6 RUNX3 SLC25A44 SEMA4A ENSG00000252236 MEX3A LMNA GLMP LAMTOR2 UBQLN4 TSACC CCT3
GH01H156153 1.3 Ensembl ENCODE dbSUPER 12.2 -39.0 -38951 3.5 CTCF PKNOX1 TAL1 EBF1 ZBTB40 RELA GATA3 POLR2A EED RUNX3 SLC25A44 ENSG00000252236 MEX3A LMNA BGLAP PAQR6 TSACC CCT3 GC01P156160 GC01P156159
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A44 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A44 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014162 68 1201 HDGF PKNOX1 MLX ARNT ARID4B SIN3A ZNF2 YY1 ZNF143 DEK

Genomic Locations for SLC25A44 Gene

Genomic Locations for SLC25A44 Gene
chr1:156,193,932-156,212,796
(GRCh38/hg38)
Size:
18,865 bases
Orientation:
Plus strand
chr1:156,163,730-156,182,587
(GRCh37/hg19)

Genomic View for SLC25A44 Gene

Genes around SLC25A44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A44 Gene

Proteins for SLC25A44 Gene

  • Protein details for SLC25A44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96H78-S2544_HUMAN
    Recommended name:
    Solute carrier family 25 member 44
    Protein Accession:
    Q96H78
    Secondary Accessions:
    • O75034

    Protein attributes for SLC25A44 Gene

    Size:
    314 amino acids
    Molecular mass:
    35392 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA32291.3; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC25A44 Gene

Post-translational modifications for SLC25A44 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC25A44 Gene

Domains & Families for SLC25A44 Gene

Gene Families for SLC25A44 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC25A44 Gene

Graphical View of Domain Structure for InterPro Entry

Q96H78

UniProtKB/Swiss-Prot:

S2544_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A44: view

Function for SLC25A44 Gene

Phenotypes From GWAS Catalog for SLC25A44 Gene

Gene Ontology (GO) - Molecular Function for SLC25A44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC25A44: view
genes like me logo Genes that share phenotypes with SLC25A44: view

Animal Model Products

miRNA for SLC25A44 Gene

miRTarBase miRNAs that target SLC25A44

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A44 Gene

Localization for SLC25A44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A44 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A44 gene
Compartment Confidence
cytoskeleton 3
mitochondrion 3
peroxisome 2
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC25A44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031307 integral component of mitochondrial outer membrane IBA --
genes like me logo Genes that share ontologies with SLC25A44: view

Pathways & Interactions for SLC25A44 Gene

SuperPathways for SLC25A44 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC25A44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006839 mitochondrial transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A44: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A44 Gene

Drugs & Compounds for SLC25A44 Gene

No Compound Related Data Available

Transcripts for SLC25A44 Gene

Unigene Clusters for SLC25A44 Gene

Solute carrier family 25, member 44:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A44 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - - - - - - - -
SP5:
SP6: -
SP7: - - - - - - - - - - -
SP8: - -
SP9:
SP10: - -

Relevant External Links for SLC25A44 Gene

GeneLoc Exon Structure for
SLC25A44
ECgene alternative splicing isoforms for
SLC25A44

Expression for SLC25A44 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A44 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A44 Gene

This gene is overexpressed in Whole Blood (x6.1).

Protein differential expression in normal tissues from HIPED for SLC25A44 Gene

This gene is overexpressed in Plasma (62.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC25A44 Gene



Protein tissue co-expression partners for SLC25A44 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC25A44 Gene:

SLC25A44

SOURCE GeneReport for Unigene cluster for SLC25A44 Gene:

Hs.532375

Evidence on tissue expression from TISSUES for SLC25A44 Gene

  • Nervous system(5)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with SLC25A44: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A44 Gene

Orthologs for SLC25A44 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A44 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A44 33 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia SLC25A44 33 34
  • 92.99 (n)
dog
(Canis familiaris)
Mammalia SLC25A44 33 34
  • 92.14 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a44 33
  • 90.13 (n)
mouse
(Mus musculus)
Mammalia Slc25a44 33 16 34
  • 90.02 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC25A44 34
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 23 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a44 33
  • 76.36 (n)
Str.7069 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3595 33
zebrafish
(Danio rerio)
Actinopterygii slc25a44a 34
  • 71 (a)
OneToMany
slc25a44b 33 34
  • 70.06 (n)
Dr.26870 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3005 33
fruit fly
(Drosophila melanogaster)
Insecta CG5805 33 34
  • 52.18 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003208 33
  • 51.69 (n)
worm
(Caenorhabditis elegans)
Secernentea F13G3.7 33 34
  • 46.62 (n)
Y43C5B.3 34
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AGC1 34
  • 8 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G15640 33
  • 46.34 (n)
rice
(Oryza sativa)
Liliopsida Os03g0754800 33
  • 49.2 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
OneToOne
Species where no ortholog for SLC25A44 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A44 Gene

ENSEMBL:
Gene Tree for SLC25A44 (if available)
TreeFam:
Gene Tree for SLC25A44 (if available)

Paralogs for SLC25A44 Gene

Paralogs for SLC25A44 Gene

genes like me logo Genes that share paralogs with SLC25A44: view

Variants for SLC25A44 Gene

Sequence variations from dbSNP and Humsavar for SLC25A44 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000044788 -- 156,192,016(+) GGTCT(A/G)TTCAA upstream-variant-2KB
rs1000077425 -- 156,192,254(+) GTTAT(A/C)CCAGA upstream-variant-2KB
rs1000184287 -- 156,212,364(+) CTTAG(G/T)GTTTC nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000191825 -- 156,207,373(+) ACGGG(A/G)TTTCA intron-variant
rs1000405143 -- 156,199,181(+) GGGTC(-/AG)GGGAG intron-variant, utr-variant-5-prime

Variation tolerance for SLC25A44 Gene

Residual Variation Intolerance Score: 37.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A44 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A44

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC25A44 Gene

Disorders for SLC25A44 Gene

Relevant External Links for SLC25A44

Genetic Association Database (GAD)
SLC25A44
Human Genome Epidemiology (HuGE) Navigator
SLC25A44
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A44

No disorders were found for SLC25A44 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A44 Gene

Publications for SLC25A44 Gene

  1. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T … Fredriksson R (Genomics 2006) 2 3 4 60
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  4. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for SLC25A44 Gene

Sources for SLC25A44 Gene

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