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Aliases for SLC25A43 Gene

Aliases for SLC25A43 Gene

  • Solute Carrier Family 25 Member 43 2 3 5
  • Solute Carrier Family 25, Member 43 2

External Ids for SLC25A43 Gene

Previous GeneCards Identifiers for SLC25A43 Gene

  • GC0XP118398
  • GC0XP118533
  • GC0XP108026

Summaries for SLC25A43 Gene

Entrez Gene Summary for SLC25A43 Gene

  • This gene encodes a member of the mitochondrial carrier family of proteins.[provided by RefSeq, Dec 2009]

GeneCards Summary for SLC25A43 Gene

SLC25A43 (Solute Carrier Family 25 Member 43) is a Protein Coding gene. An important paralog of this gene is SLC25A16.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A43 Gene

Genomics for SLC25A43 Gene

Regulatory Elements for SLC25A43 Gene

Enhancers for SLC25A43 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF119466 0.2 ENCODE 30.8 +70.1 70149 4.6 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3 NFYC REST SLC25A43 UPF3B CXorf56 ENSG00000237903 RNU1-67P RHOXF1 NKAPP1 NKRF LINC01402 ZCCHC12
GH0XF119493 0.9 Ensembl ENCODE 21.7 +96.4 96439 4.3 DMAP1 ZNF48 RAD21 RARA ZNF654 CEBPA HNF4A MYC CTCF SOX13 SLC25A43 CXorf56 SLC25A5 SLC25A5-AS1 ENSG00000226661 GC0XM119476 GC0XM119539
GH0XF119454 0.5 ENCODE 20.5 +56.7 56746 2.3 SOX13 PKNOX1 ZNF384 FEZF1 ZIC2 ZNF316 CTBP1 ZNF366 KLF7 SOX5 SLC25A43 ENSG00000226661 SLC25A5 GC0XP119457 RN7SL118P
GH0XF119512 0.8 Ensembl ENCODE 20.5 +113.4 113433 0.6 CTCF ZNF654 ARID4B ZNF384 REST RAD21 ZNF121 SMC3 BCL6 CXorf56 SLC25A43 SLC25A5 SLC25A5-AS1 RNU1-67P ENSG00000237903 ENSG00000226661 GC0XM119539 GC0XM119476
GH0XF119418 0.9 ENCODE 18.9 +20.0 19995 1.9 CTCF TFAP4 KLF1 INSM2 ZMYM3 SIN3A RAD21 HNF4G NR2F6 ZNF600 SLC25A43 ENSG00000237903
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SLC25A43 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A43 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000073056 640 2201 CREB3L1 SIN3A FEZF1 ZNF2 ZNF48 ZNF391 ZNF362 SP5 CEBPB OVOL3

Genomic Location for SLC25A43 Gene

Chromosome:
X
Start:
119,399,060 bp from pter
End:
119,454,478 bp from pter
Size:
55,419 bases
Orientation:
Plus strand

Genomic View for SLC25A43 Gene

Genes around SLC25A43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A43 Gene

Proteins for SLC25A43 Gene

  • Protein details for SLC25A43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUT9-S2543_HUMAN
    Recommended name:
    Solute carrier family 25 member 43
    Protein Accession:
    Q8WUT9
    Secondary Accessions:
    • O75854
    • Q8N9L5

    Protein attributes for SLC25A43 Gene

    Size:
    341 amino acids
    Molecular mass:
    37718 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC62432.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC25A43 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A43 Gene

Post-translational modifications for SLC25A43 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A43 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A43 Gene

Domains & Families for SLC25A43 Gene

Gene Families for SLC25A43 Gene

Suggested Antigen Peptide Sequences for SLC25A43 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WUT9

UniProtKB/Swiss-Prot:

S2543_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A43: view

Function for SLC25A43 Gene

Phenotypes for SLC25A43 Gene

GenomeRNAi human phenotypes for SLC25A43:
genes like me logo Genes that share phenotypes with SLC25A43: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A43

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A43 Gene

Localization for SLC25A43 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A43 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A43 Gene COMPARTMENTS Subcellular localization image for SLC25A43 gene
Compartment Confidence
mitochondrion 4
nucleus 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC25A43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC25A43: view

Pathways & Interactions for SLC25A43 Gene

SuperPathways for SLC25A43 Gene

No Data Available

Interacting Proteins for SLC25A43 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000217909%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000217909 Q8WUT9-S2543_HUMAN for SLC25A43 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLC25A43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A43: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A43 Gene

Transcripts for SLC25A43 Gene

Unigene Clusters for SLC25A43 Gene

Solute carrier family 25, member 43:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A43 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6
SP1: - - -
SP2: -
SP3:

Relevant External Links for SLC25A43 Gene

GeneLoc Exon Structure for
SLC25A43
ECgene alternative splicing isoforms for
SLC25A43

Expression for SLC25A43 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC25A43 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC25A43 Gene

This gene is overexpressed in Heart (64.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC25A43 Gene



Protein tissue co-expression partners for SLC25A43 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC25A43 Gene:

SLC25A43

SOURCE GeneReport for Unigene cluster for SLC25A43 Gene:

Hs.496658
genes like me logo Genes that share expression patterns with SLC25A43: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC25A43 Gene

Orthologs for SLC25A43 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A43 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A43 34 35
  • 99.7 (n)
cow
(Bos Taurus)
Mammalia SLC25A43 34 35
  • 90.91 (n)
dog
(Canis familiaris)
Mammalia SLC25A43 34 35
  • 88.86 (n)
mouse
(Mus musculus)
Mammalia Slc25a43 34 16 35
  • 85.84 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a43 34
  • 84.36 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC25A43 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A43 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC25A43 34 35
  • 72.88 (n)
lizard
(Anolis carolinensis)
Reptilia SLC25A43 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a43 34
  • 64.44 (n)
zebrafish
(Danio rerio)
Actinopterygii slc25a43 34 35
  • 61.83 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LEU5 35
  • 21 (a)
OneToMany
Species where no ortholog for SLC25A43 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC25A43 Gene

ENSEMBL:
Gene Tree for SLC25A43 (if available)
TreeFam:
Gene Tree for SLC25A43 (if available)

Paralogs for SLC25A43 Gene

Paralogs for SLC25A43 Gene

(3) SIMAP similar genes for SLC25A43 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SLC25A43 Gene

genes like me logo Genes that share paralogs with SLC25A43: view

Variants for SLC25A43 Gene

Sequence variations from dbSNP and Humsavar for SLC25A43 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs10521687 -- 119,430,207(+) CCAAT(C/T)TAGCG intron-variant
rs10713187 -- 119,451,165(+) GTCGC(-/A)AAAAA intron-variant
rs10907045 -- 119,454,408(+) ACACT(C/T)ATACA nc-transcript-variant, utr-variant-3-prime
rs111239126 -- 119,446,163(+) AAAAA(A/C)AAAAA intron-variant
rs111269098 -- 119,449,707(+) CCTGG(A/G)TAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A43 Gene

Variant ID Type Subtype PubMed ID
nsv476428 CNV novel sequence insertion 20440878
nsv518389 CNV loss 19592680

Variation tolerance for SLC25A43 Gene

Residual Variation Intolerance Score: 40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A43 Gene

Human Gene Mutation Database (HGMD)
SLC25A43
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A43

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A43 Gene

Disorders for SLC25A43 Gene

Relevant External Links for SLC25A43

Genetic Association Database (GAD)
SLC25A43
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A43

No disorders were found for SLC25A43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A43 Gene

Publications for SLC25A43 Gene

  1. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T. … Fredriksson R. (Genomics 2006) 2 3 4 64
  2. Genome-wide association identifies three new susceptibility loci for Paget's disease of bone. (PMID: 21623375) Albagha O.M. … Ralston S.H. (Nat. Genet. 2011) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Mitochondrial regulation of cell cycle progression through SLC25A43. (PMID: 26721434) Gabrielson M. … Tina E. (Biochem. Biophys. Res. Commun. 2016) 3 64
  5. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F. (Mol. Aspects Med. 2013) 3 64

Products for SLC25A43 Gene

Sources for SLC25A43 Gene

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