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Aliases for SLC25A43 Gene

Aliases for SLC25A43 Gene

  • Solute Carrier Family 25 Member 43 2 3 5
  • Solute Carrier Family 25, Member 43 2

External Ids for SLC25A43 Gene

Previous GeneCards Identifiers for SLC25A43 Gene

  • GC0XP118398
  • GC0XP118533
  • GC0XP108026

Summaries for SLC25A43 Gene

Entrez Gene Summary for SLC25A43 Gene

  • This gene encodes a member of the mitochondrial carrier family of proteins.[provided by RefSeq, Dec 2009]

GeneCards Summary for SLC25A43 Gene

SLC25A43 (Solute Carrier Family 25 Member 43) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A43 Gene

Genomics for SLC25A43 Gene

Regulatory Elements for SLC25A43 Gene

Enhancers for SLC25A43 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC25A43 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A43 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC25A43 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A43 Gene

119,399,060 bp from pter
119,454,478 bp from pter
55,419 bases
Plus strand

Genomic View for SLC25A43 Gene

Genes around SLC25A43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A43 Gene

Proteins for SLC25A43 Gene

  • Protein details for SLC25A43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 25 member 43
    Protein Accession:
    Secondary Accessions:
    • O75854
    • Q8N9L5

    Protein attributes for SLC25A43 Gene

    341 amino acids
    Molecular mass:
    37718 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC62432.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC25A43 Gene


neXtProt entry for SLC25A43 Gene

Proteomics data for SLC25A43 Gene at MOPED

Post-translational modifications for SLC25A43 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A43 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A43 Gene

Domains & Families for SLC25A43 Gene

Gene Families for SLC25A43 Gene

Protein Domains for SLC25A43 Gene

Suggested Antigen Peptide Sequences for SLC25A43 Gene

Graphical View of Domain Structure for InterPro Entry



S2543_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A43: view

Function for SLC25A43 Gene

Phenotypes for SLC25A43 Gene

GenomeRNAi human phenotypes for SLC25A43:
genes like me logo Genes that share phenotypes with SLC25A43: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A43

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A43 Gene

Localization for SLC25A43 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A43 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC25A43 Gene COMPARTMENTS Subcellular localization image for SLC25A43 gene
Compartment Confidence
mitochondrion 4
nucleus 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC25A43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with SLC25A43: view

Pathways & Interactions for SLC25A43 Gene

SuperPathways for SLC25A43 Gene

No Data Available

Interacting Proteins for SLC25A43 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000217909 Q8WUT9-S2543_HUMAN for SLC25A43 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLC25A43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A43: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A43 Gene

Drugs & Compounds for SLC25A43 Gene

No Compound Related Data Available

Transcripts for SLC25A43 Gene

Unigene Clusters for SLC25A43 Gene

Solute carrier family 25, member 43:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A43 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6
SP1: - - -
SP2: -

Relevant External Links for SLC25A43 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC25A43 Gene

mRNA expression in normal human tissues for SLC25A43 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC25A43 Gene

This gene is overexpressed in Heart (64.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC25A43 Gene

SOURCE GeneReport for Unigene cluster for SLC25A43 Gene Hs.496658

genes like me logo Genes that share expression patterns with SLC25A43: view

Protein tissue co-expression partners for SLC25A43 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC25A43 Gene

Orthologs for SLC25A43 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A43 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC25A43 35
  • 90.91 (n)
  • 92.38 (a)
SLC25A43 36
  • 90 (a)
(Canis familiaris)
Mammalia SLC25A43 35
  • 88.86 (n)
  • 89.74 (a)
SLC25A43 36
  • 89 (a)
(Mus musculus)
Mammalia Slc25a43 35
  • 85.84 (n)
  • 87.05 (a)
Slc25a43 16
Slc25a43 36
  • 86 (a)
(Pan troglodytes)
Mammalia SLC25A43 35
  • 99.7 (n)
  • 99.11 (a)
SLC25A43 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slc25a43 35
  • 84.36 (n)
  • 83.87 (a)
(Monodelphis domestica)
Mammalia SLC25A43 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia SLC25A43 36
  • 71 (a)
(Gallus gallus)
Aves SLC25A43 35
  • 72.88 (n)
  • 73.39 (a)
SLC25A43 36
  • 71 (a)
(Anolis carolinensis)
Reptilia SLC25A43 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a43 35
  • 64.44 (n)
  • 64.55 (a)
(Danio rerio)
Actinopterygii slc25a43 35
  • 61.83 (n)
  • 58.91 (a)
slc25a43 36
  • 57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LEU5 36
  • 21 (a)
Species with no ortholog for SLC25A43:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC25A43 Gene

Gene Tree for SLC25A43 (if available)
Gene Tree for SLC25A43 (if available)

Paralogs for SLC25A43 Gene

(3) SIMAP similar genes for SLC25A43 Gene using alignment to 2 proteins: Pseudogenes for SLC25A43 Gene

genes like me logo Genes that share paralogs with SLC25A43: view

No data available for Paralogs for SLC25A43 Gene

Variants for SLC25A43 Gene

Sequence variations from dbSNP and Humsavar for SLC25A43 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs3810755 - 119,453,040(-) GCTTC(A/G)GTTTT reference, missense
rs747687332 -- 119,414,508(+) AGGCA(C/G)CTGCC intron-variant
rs747689480 -- 119,404,407(+) AATAG(C/T)TAATG intron-variant
rs747695283 -- 119,442,154(+) AGATC(A/G)CTAAG intron-variant
rs747732044 -- 119,401,477(+) TGAGG(A/T)GGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A43 Gene

Variant ID Type Subtype PubMed ID
nsv518389 CNV Loss 19592680

Variation tolerance for SLC25A43 Gene

Residual Variation Intolerance Score: 40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A43 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A43 Gene

Disorders for SLC25A43 Gene

Relevant External Links for SLC25A43

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC25A43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A43 Gene

Publications for SLC25A43 Gene

  1. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T. … Fredriksson R. (Genomics 2006) 2 3 4 67
  2. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F. (Mol. Aspects Med. 2013) 3
  3. The mitochondrial transport protein SLC25A43 affects drug efficacy and drug-induced cell cycle arrest in breast cancer cell lines. (PMID: 23354756) Gabrielson M. … Tina E. (Oncol. Rep. 2013) 3
  4. DNA methylation pattern of the SLC25A43 gene in breast cancer. (PMID: 22430806) Lindqvist B.M. … Nilsson T.K. (Epigenetics 2012) 3
  5. The mitochondrial transporter SLC25A43 is frequently deleted and may influence cell proliferation in HER2-positive breast tumors. (PMID: 22883974) Tina E. … Wingren S. (BMC Cancer 2012) 3

Products for SLC25A43 Gene

Sources for SLC25A43 Gene