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Aliases for SLC25A42 Gene

Aliases for SLC25A42 Gene

  • Solute Carrier Family 25 Member 42 2 3 4 5
  • Solute Carrier Family 25, Member 42 2

External Ids for SLC25A42 Gene

Previous GeneCards Identifiers for SLC25A42 Gene

  • GC19P019036
  • GC19P019174
  • GC19P018738

Summaries for SLC25A42 Gene

Entrez Gene Summary for SLC25A42 Gene

  • This gene encodes a solute carrier family 25 protein. Solute carrier family 25 proteins are localized to mitochondria and play critical roles in the transport of molecules across the inner mitochondrial membrane. The encoded protein is a mitochondrial transporter for coenzyme A (CoA) and adenosine 3',5'-diphosphate. [provided by RefSeq, Feb 2012]

GeneCards Summary for SLC25A42 Gene

SLC25A42 (Solute Carrier Family 25 Member 42) is a Protein Coding gene. GO annotations related to this gene include ATP transmembrane transporter activity and coenzyme A transmembrane transporter activity. An important paralog of this gene is SLC25A16.

UniProtKB/Swiss-Prot for SLC25A42 Gene

  • Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3,5-diphosphate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A42 Gene

Genomics for SLC25A42 Gene

Regulatory Elements for SLC25A42 Gene

Enhancers for SLC25A42 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC25A42 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A42 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC25A42 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A42 Gene

Chromosome:
19
Start:
19,063,966 bp from pter
End:
19,113,030 bp from pter
Size:
49,065 bases
Orientation:
Plus strand

Genomic View for SLC25A42 Gene

Genes around SLC25A42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A42 Gene

Proteins for SLC25A42 Gene

  • Protein details for SLC25A42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VD7-S2542_HUMAN
    Recommended name:
    Mitochondrial coenzyme A transporter SLC25A42
    Protein Accession:
    Q86VD7
    Secondary Accessions:
    • D2T2J5
    • O14553
    • O43378

    Protein attributes for SLC25A42 Gene

    Size:
    318 amino acids
    Molecular mass:
    35409 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC02758.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SLC25A42 Gene

Proteomics data for SLC25A42 Gene at MOPED

Post-translational modifications for SLC25A42 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A42 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A42 Gene

Domains & Families for SLC25A42 Gene

Gene Families for SLC25A42 Gene

Suggested Antigen Peptide Sequences for SLC25A42 Gene

Graphical View of Domain Structure for InterPro Entry

Q86VD7

UniProtKB/Swiss-Prot:

S2542_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A42: view

Function for SLC25A42 Gene

Molecular function for SLC25A42 Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3,5-diphosphate.

Gene Ontology (GO) - Molecular Function for SLC25A42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015228 coenzyme A transmembrane transporter activity IDA 19429682
GO:0080122 AMP transmembrane transporter activity IDA 19429682
genes like me logo Genes that share ontologies with SLC25A42: view
genes like me logo Genes that share phenotypes with SLC25A42: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A42

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A42 Gene

Localization for SLC25A42 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A42 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A42 Gene COMPARTMENTS Subcellular localization image for SLC25A42 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2
peroxisome 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for SLC25A42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with SLC25A42: view

Pathways & Interactions for SLC25A42 Gene

SuperPathways for SLC25A42 Gene

No Data Available

Interacting Proteins for SLC25A42 Gene

Gene Ontology (GO) - Biological Process for SLC25A42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IBA --
GO:0080121 AMP transport IDA 19429682
genes like me logo Genes that share ontologies with SLC25A42: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A42 Gene

Drugs & Compounds for SLC25A42 Gene

No Compound Related Data Available

Transcripts for SLC25A42 Gene

Unigene Clusters for SLC25A42 Gene

Solute carrier family 25, member 42:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A42 Gene

No ASD Table

Relevant External Links for SLC25A42 Gene

GeneLoc Exon Structure for
SLC25A42
ECgene alternative splicing isoforms for
SLC25A42

Expression for SLC25A42 Gene

mRNA expression in normal human tissues for SLC25A42 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A42 Gene

This gene is overexpressed in Liver (x5.2).

Protein differential expression in normal tissues from HIPED for SLC25A42 Gene

This gene is overexpressed in Brain (19.5), Liver (12.4), and Gallbladder (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A42 Gene



SOURCE GeneReport for Unigene cluster for SLC25A42 Gene Hs.303669

genes like me logo Genes that share expression patterns with SLC25A42: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SLC25A42 Gene

Orthologs for SLC25A42 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A42 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC25A42 35
  • 91.3 (n)
  • 92.77 (a)
SLC25A42 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A42 35
  • 89.94 (n)
  • 92.77 (a)
SLC25A42 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a42 35
  • 85.85 (n)
  • 92.14 (a)
Slc25a42 16
Slc25a42 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC25A42 35
  • 99.69 (n)
  • 100 (a)
SLC25A42 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a42 35
  • 85.12 (n)
  • 91.51 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC25A42 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A42 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC25A42 35
  • 72.87 (n)
  • 77.29 (a)
SLC25A42 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a42 35
  • 68.87 (n)
  • 77.6 (a)
zebrafish
(Danio rerio)
Actinopterygii slc25a42 35
  • 70.14 (n)
  • 74.13 (a)
slc25a42 36
  • 72 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000097 35
  • 60.37 (n)
  • 58.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta att-ORFA 35
  • 61.82 (n)
  • 59.57 (a)
att-ORFA 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F43G9.3 35
  • 52.16 (n)
  • 56.12 (a)
F43G9.3 36
  • 54 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LEU5 36
  • 28 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G26180 35
  • 49.39 (n)
  • 42.34 (a)
Species with no ortholog for SLC25A42:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A42 Gene

ENSEMBL:
Gene Tree for SLC25A42 (if available)
TreeFam:
Gene Tree for SLC25A42 (if available)

Paralogs for SLC25A42 Gene

Paralogs for SLC25A42 Gene

(7) SIMAP similar genes for SLC25A42 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC25A42: view

Variants for SLC25A42 Gene

Sequence variations from dbSNP and Humsavar for SLC25A42 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs17854359 - 19,101,814(+) TGCTG(C/T)CTGGG reference, missense
rs17854358 - 19,110,853(+) AGATC(A/C)TGCTG reference, missense
rs7256152 -- 19,090,132(+) ATTTT(A/G)AGAAG intron-variant
rs7256648 -- 19,084,534(+) TGGGG(C/G)AGGAG intron-variant
rs7259609 -- 19,090,712(+) GGGGA(A/G)CTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A42 Gene

Variant ID Type Subtype PubMed ID
nsv833778 CNV Loss 17160897
nsv833779 CNV Loss 17160897
esv28513 CNV Loss 19812545

Variation tolerance for SLC25A42 Gene

Residual Variation Intolerance Score: 55.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.81% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC25A42 Gene

Disorders for SLC25A42 Gene

Relevant External Links for SLC25A42

Genetic Association Database (GAD)
SLC25A42
Human Genome Epidemiology (HuGE) Navigator
SLC25A42
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A42

No disorders were found for SLC25A42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A42 Gene

Publications for SLC25A42 Gene

  1. A novel member of solute carrier family 25 (SLC25A42) is a transporter of coenzyme A and adenosine 3',5'-diphosphate in human mitochondria. (PMID: 19429682) Fiermonte G. … Palmieri F. (J. Biol. Chem. 2009) 2 3 4 67
  2. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T. … Fredriksson R. (Genomics 2006) 2 3
  3. Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome. (PMID: 26465331) Grose J.H. … Benjamin I.J. (PLoS ONE 2015) 3
  4. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F. (Mol. Aspects Med. 2013) 3
  5. The functional interactome landscape of the human histone deacetylase family. (PMID: 23752268) Joshi P. … Cristea I.M. (Mol. Syst. Biol. 2013) 3

Products for SLC25A42 Gene

Sources for SLC25A42 Gene

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