SLC25A42 Gene
protein-coding GIFtS: 45
GCID: GC19P019174
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|
solute carrier family 25, member 42
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Aliases
for SLC25A42 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 25, Member 421 2 | | MGC266941 | | Mitochondrial Coenzyme A Transporter SLC25A422 | | Solute Carrier Family 25 Member 423 |
Export aliases for SLC25A42 gene to outside databasesPrevious GC identifers: GC19P019036 GC19P018738 |
Summaries
for SLC25A42 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLC25A42:
This gene encodes a solute carrier family 25 protein. Solute carrier family 25 proteins are localized to mitochondriaand play critical roles in the transport of molecules across the inner mitochondrial membrane. The encoded protein isa mitochondrial transporter for coenzyme A (CoA) and adenosine 3',5'-diphosphate. (provided by RefSeq, Feb 2012)
UniProtKB/Swiss-Prot: S2542_HUMAN, Q86VD7Function: Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange forintramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate
|
Genomic Views
for SLC25A42 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC25A42 gene promoter:
STAT1 STAT1beta CUTL1 NF-E2 p45 STAT1alpha COMP1 IRF-7A Sox9 NF-E2 CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC25A42
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC25A42 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.11SLC25A42 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P019174: view genomic region
(about GC identifiers)
Start:
|
19,174,803 bp from pter |
End:
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19,223,704 bp from pter |
Size:
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48,902 bases |
Orientation:
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plus strand |
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Proteins
for SLC25A42 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S2542_HUMAN, Q86VD7 (See
protein sequence)Recommended Name: Mitochondrial coenzyme A transporter SLC25A42 Size: 318 amino acids; 35409 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAC02758.1; Type=Erroneous gene model prediction;
Secondary accessions: D2T2J5 O14553 O43378Explore the universe of human proteins at neXtProt for SLC25A42: NX_Q86VD7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86VD7
SLC25A42 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_848621.2
ENSEMBL proteins: ENSP00000326693
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SLC25A42 for ontologies About GeneDecksing
SLC25A42 Antibody Products:
Assay Products for SLC25A42: |
Protein
Domains /
Families
for SLC25A42 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC25A42 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86VD7ProtoNet protein and cluster: Q86VD7 2 Blocks protein families: IPB002067 Mitochondrial carrier protein signature IPB002167 Graves disease carrier protein signature
UniProtKB/Swiss-Prot: S2542_HUMAN, Q86VD7Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) familySimilarity: Contains 3 Solcar repeats |
Function
for SLC25A42 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: S2542_HUMAN, Q86VD7Function: Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange forintramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A42
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A42 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
SLC25A42 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SLC25A42:
|
Pathways & Interactions
for SLC25A42 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC25A42
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
SLC25A42 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC25A42 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC25A42
Search CenterWatch for drugs/clinical trials and news about SLC25A42 / S2542
|
Transcripts
for SLC25A42 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC25A42 gene: NM_178526.4 Unigene Cluster for SLC25A42: Solute carrier family 25, member 42 Hs.303669 [show with all ESTs]Unigene Representative Sequence: NM_1785261 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000318596(uc002nlf.2 uc010xqn.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A42 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A42
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLC25A42 (NM_178526) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC25A42 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A42 |
Additional cDNA sequence: AF521885.1 BC041973.1 BC045598.1 FN356975.1 10 DOTS entries: DT.216922 DT.211838 DT.100724254 DT.100779136 DT.95207368 DT.438761 DT.75101867 DT.95194918 DT.95207381 DT.95207389 24/169 AceView cDNA sequences (see all 169): AI004772 BF057438 Z39994 AW002167 AI885292 AI569586 BQ955212 AI244960 AI803483 BX363381 AI799292 BQ448132 BU608075 CB054708 AI365474 CD109207 AW206594 F36456 BQ445895 AI459101 AA912858 AA926712 AI057363 AI376807
GeneLoc Exon Structure
|
Expression
for SLC25A42 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC25A42 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGACACTGT
About this image
See SLC25A42 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC25A42
SOURCE GeneReport for Unigene cluster: Hs.303669
SABiosciences Custom PCR Arrays for SLC25A42
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC25A42
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC25A42 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC25A42 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC25A42 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A42 |
Orthologs
for SLC25A42 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC25A42 gene from 6/22 species (see all 22) About this table
ENSEMBL Gene Tree for SLC25A42 (if available)
TreeFam Gene Tree for SLC25A42 (if available) |
Paralogs
for SLC25A42 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC25A42 gene
- SLC25A242 SLC25A232 SLC25A252 SLC25A162 SLC25A412
6 SIMAP similar genes for SLC25A42 using alignment to 1 protein entry: S2542_HUMAN:SLC25A17 SLC25A16 SLC25A41 SLC25A43 SLC25A4 SLC25A6
SLC25A42 for paralogs About GeneDecksing
|
Genomic Variants
for SLC25A42 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC25A42 (19174803 - 19223704 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SLC25A42
1 CNV: 73326 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC25A42 |
|
Disorders
/ Diseases
for SLC25A42 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC25A42 for disorders About GeneDecksing
OMIM gene information: 610823
OMIM disorders: --
1  disease for SLC25A42: About MalaCardsgraves' disease
Human Genome Epidemiology (HuGE) Navigator: SLC25A42 (3 documents)
Export disorders for SLC25A42 gene to outside databases
|
Publications
for SLC25A42 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC25A42 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC25A42) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel member of solute carrier family 25 (SLC25A42) is a transporter of coenzyme A and adenosine 3',5'-diphosphate in human mitoch ondria. (PubMed id 19429682)1, 2, 3 Fiermonte G....Palmieri F. (2009)
- Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PubMed id 16949250)1, 2, 3 Haitina T.... Fredriksson R. (2006)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SLC25A42 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC25A42 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC25A42 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC25A42 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC25A42 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC25A42 gene:
Search GeneIP for patents involving SLC25A42
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC25A42 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | SLC25A42 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A42 |
|  |  |  | | | | Search ThermoFisher Antibodies for SLC25A42 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A42 |
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