Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC25A42 Gene

Aliases for SLC25A42 Gene

  • Solute Carrier Family 25, Member 42 2 3
  • Solute Carrier Family 25 Member 42 4

External Ids for SLC25A42 Gene

Summaries for SLC25A42 Gene

Entrez Gene Summary for SLC25A42 Gene

  • This gene encodes a solute carrier family 25 protein. Solute carrier family 25 proteins are localized to mitochondria and play critical roles in the transport of molecules across the inner mitochondrial membrane. The encoded protein is a mitochondrial transporter for coenzyme A (CoA) and adenosine 3',5'-diphosphate. [provided by RefSeq, Feb 2012]

GeneCards Summary for SLC25A42 Gene

SLC25A42 (Solute Carrier Family 25, Member 42) is a Protein Coding gene. GO annotations related to this gene include ATP transmembrane transporter activity and coenzyme A transmembrane transporter activity. An important paralog of this gene is SLC25A16.

UniProtKB/Swiss-Prot for SLC25A42 Gene

  • Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3,5-diphosphate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A42 Gene

Genomics for SLC25A42 Gene

Genomic Location for SLC25A42 Gene

Start:
19,063,994 bp from pter
End:
19,113,030 bp from pter
Size:
49,037 bases
Orientation:
Plus strand

Genomic View for SLC25A42 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC25A42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A42 Gene

Regulatory Elements for SLC25A42 Gene

Proteins for SLC25A42 Gene

  • Protein details for SLC25A42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VD7-S2542_HUMAN
    Recommended name:
    Mitochondrial coenzyme A transporter SLC25A42
    Protein Accession:
    Q86VD7
    Secondary Accessions:
    • D2T2J5
    • O14553
    • O43378

    Protein attributes for SLC25A42 Gene

    Size:
    318 amino acids
    Molecular mass:
    35409 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC02758.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SLC25A42 Gene

Proteomics data for SLC25A42 Gene at MOPED

Post-translational modifications for SLC25A42 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A42 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A42 Gene

Domains for SLC25A42 Gene

Gene Families for SLC25A42 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

UniProtKB/Swiss-Prot:

S2542_HUMAN
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.:
    • Q86VD7
Similarity:
  • Contains 3 Solcar repeats.:
    • Q86VD7
genes like me logo Genes that share domains with SLC25A42: view

Function for SLC25A42 Gene

Molecular function for SLC25A42 Gene

UniProtKB/Swiss-Prot Function: Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3,5-diphosphate.

Gene Ontology (GO) - Molecular Function for SLC25A42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005347 ATP transmembrane transporter activity IDA 19429682
GO:0015217 ADP transmembrane transporter activity IDA 19429682
GO:0015228 coenzyme A transmembrane transporter activity IDA 19429682
GO:0043262 adenosine-diphosphatase activity IDA 19429682
GO:0080122 AMP transmembrane transporter activity IDA 19429682
genes like me logo Genes that share ontologies with SLC25A42: view

Phenotypes for SLC25A42 Gene

GenomeRNAi human phenotypes for SLC25A42:
genes like me logo Genes that share phenotypes with SLC25A42: view

miRNA for SLC25A42 Gene

miRTarBase miRNAs that target SLC25A42

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC25A42 Gene

Localization for SLC25A42 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A42 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A42 Gene COMPARTMENTS Subcellular localization image for SLC25A42 gene
Compartment Confidence
mitochondrion 5
nucleus 3
cytosol 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for SLC25A42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC25A42: view

Pathways for SLC25A42 Gene

SuperPathways for SLC25A42 Gene

No Data Available

Interacting Proteins for SLC25A42 Gene

Gene Ontology (GO) - Biological Process for SLC25A42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IDA 19429682
GO:0015866 ADP transport IDA 19429682
GO:0015867 ATP transport IDA 19429682
GO:0035349 coenzyme A transmembrane transport IDA 19429682
GO:0080121 AMP transport IDA 19429682
genes like me logo Genes that share ontologies with SLC25A42: view

No data available for Pathways by source for SLC25A42 Gene

Transcripts for SLC25A42 Gene

Unigene Clusters for SLC25A42 Gene

Solute carrier family 25, member 42:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A42 Gene

No ASD Table

Relevant External Links for SLC25A42 Gene

GeneLoc Exon Structure for
SLC25A42
ECgene alternative splicing isoforms for
SLC25A42

Expression for SLC25A42 Gene

mRNA expression in normal human tissues for SLC25A42 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A42 Gene

This gene is overexpressed in Liver (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A42 Gene

SOURCE GeneReport for Unigene cluster for SLC25A42 Gene Hs.303669

genes like me logo Genes that share expressions with SLC25A42: view

Orthologs for SLC25A42 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A42 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A42 36
  • 99.69 (n)
  • 100 (a)
SLC25A42 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC25A42 36
  • 91.3 (n)
  • 92.77 (a)
SLC25A42 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A42 36
  • 89.94 (n)
  • 92.77 (a)
SLC25A42 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a42 36
  • 85.85 (n)
  • 92.14 (a)
Slc25a42 16
Slc25a42 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC25A42 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A42 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a42 36
  • 85.12 (n)
  • 91.51 (a)
chicken
(Gallus gallus)
Aves SLC25A42 36
  • 72.87 (n)
  • 77.29 (a)
SLC25A42 37
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a42 36
  • 68.87 (n)
  • 77.6 (a)
zebrafish
(Danio rerio)
Actinopterygii slc25a42 36
  • 70.14 (n)
  • 74.13 (a)
slc25a42 37
  • 72 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000097 36
  • 60.37 (n)
  • 58.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta att-ORFA 36
  • 61.82 (n)
  • 59.57 (a)
att-ORFA 37
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F43G9.3 36
  • 52.16 (n)
  • 56.12 (a)
F43G9.3 37
  • 54 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LEU5 37
  • 28 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G26180 36
  • 49.39 (n)
  • 42.34 (a)
Species with no ortholog for SLC25A42:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A42 Gene

ENSEMBL:
Gene Tree for SLC25A42 (if available)
TreeFam:
Gene Tree for SLC25A42 (if available)

Paralogs for SLC25A42 Gene

Paralogs for SLC25A42 Gene

Selected SIMAP similar genes for SLC25A42 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC25A42: view

Variants for SLC25A42 Gene

Sequence variations from dbSNP and Humsavar for SLC25A42 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs757220 -- 19,092,900(+) TGTTG(C/T)GGGGG intron-variant
rs757221 -- 19,093,090(+) atcac(A/G)gctca intron-variant
rs757222 -- 19,093,114(+) ctctt(G/T)ggctc intron-variant
rs916898 -- 19,069,010(+) TGACA(A/G)TGAGG intron-variant
rs1007483 -- 19,098,636(+) AGCCT(C/T)ggctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A42 Gene

Variant ID Type Subtype PubMed ID
nsv833778 CNV Loss 17160897
nsv833779 CNV Loss 17160897
esv28513 CNV Loss 19812545

Relevant External Links for SLC25A42 Gene

HapMap Linkage Disequilibrium report
SLC25A42

Disorders for SLC25A42 Gene

Relevant External Links for SLC25A42

Genetic Association Database (GAD)
SLC25A42
Human Genome Epidemiology (HuGE) Navigator
SLC25A42
genes like me logo Genes that share disorders with SLC25A42: view

No data available for UniProtKB/Swiss-Prot for SLC25A42 Gene

Publications for SLC25A42 Gene

  1. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T. … Fredriksson R. (Genomics 2006) 2 3 4
  2. A novel member of solute carrier family 25 (SLC25A42) is a transporter of coenzyme A and adenosine 3',5'-diphosphate in human mitochondria. (PMID: 19429682) Fiermonte G. … Palmieri F. (J. Biol. Chem. 2009) 2 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  5. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3

Products for SLC25A42 Gene

Sources for SLC25A42 Gene

Back to Top

Content