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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC25A41 Gene

protein-coding GIFtS: 40
GCID: GC19M006426

solute carrier family 25, member 41

Explore 1 disease affiliated with
SLC25A41 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 25, Member 41¹ ²
APC4¹ ²
FLJ40442¹
MGC34725¹
Solute Carrier Family 25 Member 41²

External Ids:	HGNC: 28533¹	Entrez Gene: 284427²	Ensembl: ENSG00000181240⁷	OMIM: 610822⁵	UniProtKB: Q8N5S1³

Export aliases for SLC25A41 gene to outside databases

Previous GC identifers: GC19M006378 GC19M006186

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC25A41:

SLC25A41 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 (PubMed

16949250)).(supplied by OMIM, Mar 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011255.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC25A41 gene promoter:
RP58 Pax-5 HOXA3 NF-kappaB AREB6 CREB deltaCREB STAT3 c-Myb NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC25A41 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC25A41

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC25A41

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3

SLC25A41 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A41 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M006426: view genomic region (about GC identifiers)

Start:	6,426,048 bp from pter	End:	6,433,790 bp from pter
Size:	7,743 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S2541_HUMAN, Q8N5S1 (See protein sequence)

Recommended Name: Solute carrier family 25 member 41

Size: 370 amino acids; 40795 Da

Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)

Sequence caution: Sequence=AAH31671.1; Type=Erroneous initiation; Sequence=BAC05163.1; Type=Erroneous translation;

Note=Wrong choice of CDS;

Secondary accessions: A8MQ40 D6W642 Q8N7R4

Alternative splicing: 2 isoforms: Q8N5S1-1 Q8N5S1-2 (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for SLC25A41: NX_Q8N5S1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N5S1

SLC25A41 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_775908.2

ENSEMBL proteins:

ENSP00000322649 ENSP00000405411

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Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	--	--
GO:0005743	mitochondrial inner membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

SLC25A41 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC25A41 for domains About GeneDecksing

3 InterPro domains/families:

IPR002067 Mit_carrier

IPR023395 Mt_carrier_dom

IPR018108 Mitochondrial_sb/sol_carrier

Graphical View of Domain Structure for InterPro Entry Q8N5S1

ProtoNet protein and cluster: Q8N5S1

UniProtKB/Swiss-Prot: S2541_HUMAN, Q8N5S1

Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family

Similarity: Contains 3 Solcar repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLC25A41

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0055085	transmembrane transport	IEA	--

SLC25A41 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for SLC25A41 gene:

NM_173637.3

Unigene Cluster for SLC25A41:

Solute carrier family 25, member 41

Hs.375135 [show with all ESTs]

Unigene Representative Sequence: AK097761

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000321510(uc010dus.3) ENST00000458275(uc010dut.3)

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Additional cDNA sequence:

AK097761.1 BC031671.1

2 DOTS entries:

DT.40247402 DT.95148956

7 AceView cDNA sequences:

BC031671 BI825710 NM_173637 AK097761 AI678642 BI825442 AA909324

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC25A41 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCACACAACA

About this image
See SLC25A41 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC25A41

SOURCE GeneReport for Unigene cluster: Hs.375135

SABiosciences Custom PCR Arrays for SLC25A41

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A41 gene from 6/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- --	--	61(a) 24(a)	many ↔ many many ↔ many	2(76355536-76362271) 2(76324542-76352071)
zebrafish (Danio rerio)	Actinopterygii	si:dkey-204f11.59⁶ AL929150.1⁶ (see all 3)	--	39(a) 37(a) (see all 3)	many ↔ many many ↔ many (see all 3)	3(34304791-34315861) 1(55517970-55536713)
fruit fly (Drosophila melanogaster)	Insecta	CG32103⁶	--	28(a)	1 → many	3L(12395395-12407942)
worm (Caenorhabditis elegans)	Secernentea	F17E5.2⁶ F55A11.4⁶	Probable calcium-binding mitochondrial carrier F17... Putative calcium-binding mitochondrial carrier F55...	30(a) 29(a)	many ↔ many many ↔ many	X(12394197-12399422) V(11771228-11773477)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G07320⁶ AT5G61810⁶ (see all 3)	Mitochondrial substrate carrier family protein (see all 3)	27(a) 27(a) (see all 3)	many ↔ many many ↔ many (see all 3)	5(2309911-2312287) 5(24831619-24833902)
rice (Oryza sativa)	Liliopsida	-- --	calcium-binding mitochondrial carrier CBG00135, pu... calcium-binding mitochondrial carrier CBG00135, pu...	28(a) 26(a)	many ↔ many many ↔ many	6(23934978-23941396) 2(5663004-5668429)

ENSEMBL Gene Tree for SLC25A41 (if available)
TreeFam Gene Tree for SLC25A41 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC25A41 gene

SLC25A24² SLC25A23² SLC25A42² SLC25A25² SLC25A16²

4 SIMAP similar genes for SLC25A41 using alignment to 1 protein entry: S2541_HUMAN:

SLC25A24 SLC25A25 SLC25A23 SLC25A42

SLC25A41 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186027551^1,2		--	6427015(+)	`AGACAC/TGGAGG`	1	--	int¹		0	--	--	--	--
rs62107579^1,2	C,	--	6427087(+)	`GCATGC/TGTGGT`	1	--	int¹		2		NA	122
rs189986398^1,2	C,	--	6427088(+)	`CATGCA/GTGGTG`	1	--	int¹		0	--	--	--	--
rs112166427^1,2	C,	--	6427097(+)	`TGGCCG/ACTGGG`	1	--	int¹		1		WA	2
rs201552211^1,2		--	6427124(+)	`GCCTGC/TATCCT`	2	I M	mis¹		0	--	--	--	--
rs142507496^1,2	C,	--	6427272(+)	`AGAGAA/TGGGGG`	1	--	int¹		0	--	--	--	--
rs200557483^1,2		--	6427279(+)	`GGGGCC/TAGGAG`	1	--	int¹		0	--	--	--	--
rs200181105^1,2	C,F,	--	6427302(+)	`GAGCCT/CGGGCT`	1	--	int¹		1		EU	533
rs11883242^1,2	C,F,H,	--	6427364(+)	`GGTCGG/CTGCAG`	2	/T /S	mis¹ ese³		11		NS EA NA WA	1068
rs3760750^1,2	C,F,H,	--	6427408(-)	`TACCGC/TGGCTA`	2	R	syn¹ ese³		22		NS EA NA EU	2691

HapMap Linkage Disequilibrium report for SLC25A41 (6426048 - 6433790 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC25A41: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC25A41 for disorders           About GeneDecksing

OMIM gene information: 610822    OMIM disorders: --

1 disease for SLC25A41:    About MalaCards

malaria

Export disorders for SLC25A41 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLC25A41 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC25A41)

Utopia: connect your pdf to the dynamic
world of online information

Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PubMed id 16949250)^{1, 2, 3} Haitina T.... Fredriksson R. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 284427	HGNC: 28533	AceView: MGC34725	Ensembl:ENSG00000181240	euGenes: HUgn284427
ECgene: SLC25A41	H-InvDB: SLC25A41

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLC25A41	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC25A41 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SLC25A41 gene:
Search GeneIP for patents involving SLC25A41

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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SLC25A41 Gene

solute carrier family 25, member 41

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for SLC25A41 gene

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SLC25A41 Gene

solute carrier family 25, member 41

Aliasesfor SLC25A41 gene

Summariesfor SLC25A41 gene

Genomic Viewsfor SLC25A41 gene

Proteinsfor SLC25A41 gene

Protein Domains /Familiesfor SLC25A41 gene

Functionfor SLC25A41 gene

Pathways & Interactionsfor SLC25A41 gene

Drugs & Compoundsfor SLC25A41 gene

Transcriptsfor SLC25A41 gene

Expression for SLC25A41 gene

Orthologsfor SLC25A41 gene

Paralogsfor SLC25A41 gene

Genomic Variantsfor SLC25A41 gene

Disorders / Diseasesfor SLC25A41 gene

Publicationsfor SLC25A41 gene

External Searches for SLC25A41 gene

Genome Databases showing SLC25A41 gene

Other Databases showing SLC25A41 gene

Specialized Databases showing SLC25A41 gene

Intellectual Propertyfor SLC25A41 gene

Productsfor SLC25A41 gene

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Aliases
for SLC25A41 gene

Summaries
for SLC25A41 gene

Genomic Views
for SLC25A41 gene

Proteins
for SLC25A41 gene

Protein Domains /
Families
for SLC25A41 gene

Function
for SLC25A41 gene

Pathways & Interactions
for SLC25A41 gene

Drugs & Compounds
for SLC25A41 gene

Transcripts
for SLC25A41 gene

Expression
for SLC25A41 gene

Orthologs
for SLC25A41 gene

Paralogs
for SLC25A41 gene

Genomic Variants
for SLC25A41 gene

Disorders / Diseases
for SLC25A41 gene

Publications
for SLC25A41 gene

Intellectual Property
for SLC25A41 gene

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for SLC25A41 gene