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Aliases for SLC25A41 Gene

Aliases for SLC25A41 Gene

  • Solute Carrier Family 25 Member 41 2 3 5
  • Solute Carrier Family 25, Member 41 2
  • APC4 3

External Ids for SLC25A41 Gene

Previous GeneCards Identifiers for SLC25A41 Gene

  • GC19M006378
  • GC19M006186

Summaries for SLC25A41 Gene

Entrez Gene Summary for SLC25A41 Gene

  • SLC25A41 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC25A41 Gene

SLC25A41 (Solute Carrier Family 25 Member 41) is a Protein Coding gene. An important paralog of this gene is SLC25A23.

Additional gene information for SLC25A41 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A41 Gene

Genomics for SLC25A41 Gene

Regulatory Elements for SLC25A41 Gene

Enhancers for SLC25A41 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H006411 1 Ensembl ENCODE 36.3 +23.0 23034 2 CTCF ARID4B ZNF2 RAD21 HIC1 POLR2A PATZ1 SCRT2 SNRNP70 PAF1 SLC25A41 KHSRP ZNF557 SAFB DUS3L SAFB2 SNRPEP4 ENSG00000267571 GTF2F1 GC19P006415
GH19H006401 1.1 Ensembl ENCODE 22.7 +33.4 33357 2 ARID4B ZNF2 RARA HSF1 CREM THAP11 HMG20B SP5 KAT8 RFX3 SLC25A41 DUS3L PIR56098 GC19P006404 GTF2F1
GH19H006055 2 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +373.8 373787 13 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 YY1 ZNF766 ZNF548 FOS RFX2 ACSBG2 DUS3L PRR22 SAFB SNRPEP4 SLC25A41 KHSRP CATSPERD DENND1C
GH19H005956 1.9 FANTOM5 Ensembl ENCODE dbSUPER 8.5 +473.0 473015 13 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B FEZF1 DMAP1 YY1 SLC30A9 VMAC CAPS NDUFA11 FUT5 ACSBG2 ENSG00000267571 GPR108 DUS3L FUT3 FUT6
GH19H006457 1.1 ENCODE 6.6 -23.2 -23212 3 HDGF PKNOX1 FOXA2 MLX ARNT SIN3A ARID4B FEZF1 DMAP1 ZNF2 KHSRP SNRPEP4 RANBP3 SLC25A23 VMAC ENSG00000267571 ZNF557 LOC390877 FLJ25758 MBD3L3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A41 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A41 Gene

Chromosome:
19
Start:
6,426,037 bp from pter
End:
6,436,267 bp from pter
Size:
10,231 bases
Orientation:
Minus strand

Genomic View for SLC25A41 Gene

Genes around SLC25A41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A41 Gene

Proteins for SLC25A41 Gene

  • Protein details for SLC25A41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5S1-S2541_HUMAN
    Recommended name:
    Solute carrier family 25 member 41
    Protein Accession:
    Q8N5S1
    Secondary Accessions:
    • A8MQ40
    • D6W642
    • Q8N7R4

    Protein attributes for SLC25A41 Gene

    Size:
    370 amino acids
    Molecular mass:
    40795 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH31671.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC05163.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC25A41 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A41 Gene

Post-translational modifications for SLC25A41 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A41 Gene

No data available for DME Specific Peptides for SLC25A41 Gene

Domains & Families for SLC25A41 Gene

Gene Families for SLC25A41 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for SLC25A41 Gene

Suggested Antigen Peptide Sequences for SLC25A41 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5S1

UniProtKB/Swiss-Prot:

S2541_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A41: view

Function for SLC25A41 Gene

Gene Ontology (GO) - Molecular Function for SLC25A41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005347 ATP transmembrane transporter activity IBA --
GO:0015217 ADP transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC25A41: view

Phenotypes for SLC25A41 Gene

genes like me logo Genes that share phenotypes with SLC25A41: view

Animal Model Products

CRISPR Products

miRNA for SLC25A41 Gene

miRTarBase miRNAs that target SLC25A41

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC25A41
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A41 Gene

Localization for SLC25A41 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A41 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A41 gene
Compartment Confidence
mitochondrion 4
plasma membrane 1
extracellular 1
nucleus 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLC25A41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with SLC25A41: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC25A41 Gene

Pathways & Interactions for SLC25A41 Gene

SuperPathways for SLC25A41 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC25A41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006839 mitochondrial transport IBA --
GO:0015866 ADP transport IEA --
GO:0015867 ATP transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A41: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A41 Gene

Drugs & Compounds for SLC25A41 Gene

No Compound Related Data Available

Transcripts for SLC25A41 Gene

mRNA/cDNA for SLC25A41 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC25A41 Gene

Solute carrier family 25, member 41:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC25A41
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A41 Gene

No ASD Table

Relevant External Links for SLC25A41 Gene

GeneLoc Exon Structure for
SLC25A41
ECgene alternative splicing isoforms for
SLC25A41

Expression for SLC25A41 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A41 Gene

mRNA differential expression in normal tissues according to GTEx for SLC25A41 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.5), Brain - Cerebellum (x6.0), Testis (x5.2), and Brain - Nucleus accumbens (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for SLC25A41 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC25A41 Gene



Protein tissue co-expression partners for SLC25A41 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC25A41 Gene:

SLC25A41

SOURCE GeneReport for Unigene cluster for SLC25A41 Gene:

Hs.375135
genes like me logo Genes that share expression patterns with SLC25A41: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A41 Gene

Orthologs for SLC25A41 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC25A41 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A41 33 34
  • 98.74 (n)
dog
(Canis familiaris)
Mammalia SLC25A41 33 34
  • 88.22 (n)
mouse
(Mus musculus)
Mammalia Slc25a41 33 16 34
  • 84.44 (n)
cow
(Bos Taurus)
Mammalia SLC25A23 33
  • 84.14 (n)
SLC25A41 34
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a41 33
  • 83.22 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC25A41 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 52 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 51 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-204f11.59 34
  • 39 (a)
ManyToMany
si:ch211-196h16.11 34
  • 38 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG32103 34
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F17E5.2 34
  • 30 (a)
ManyToMany
F55A11.4 34
  • 29 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5381 34
  • 26 (a)
OneToMany
Species where no ortholog for SLC25A41 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC25A41 Gene

ENSEMBL:
Gene Tree for SLC25A41 (if available)
TreeFam:
Gene Tree for SLC25A41 (if available)

Paralogs for SLC25A41 Gene

Paralogs for SLC25A41 Gene

(4) SIMAP similar genes for SLC25A41 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC25A41: view

Variants for SLC25A41 Gene

Sequence variations from dbSNP and Humsavar for SLC25A41 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000362447 -- 6,425,573(+) CTGCC(C/G)GAACT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1000422722 -- 6,432,000(+) TTCTC(C/T)CCAGT intron-variant
rs1000444622 -- 6,436,756(+) TTGGC(C/T)AGGCT intron-variant, upstream-variant-2KB
rs1000699920 -- 6,436,442(+) ATAAG(G/T)CTGCT upstream-variant-2KB, reference, missense, utr-variant-3-prime
rs1000758584 -- 6,431,398(+) TGTGA(A/G)ATATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A41 Gene

Variant ID Type Subtype PubMed ID
nsv1129197 CNV insertion 24896259
nsv1129617 CNV tandem duplication 24896259
nsv833727 CNV loss 17160897

Variation tolerance for SLC25A41 Gene

Residual Variation Intolerance Score: 94.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.80; 73.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A41 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A41

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A41 Gene

Disorders for SLC25A41 Gene

Relevant External Links for SLC25A41

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A41

No disorders were found for SLC25A41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A41 Gene

Publications for SLC25A41 Gene

  1. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T … Fredriksson R (Genomics 2006) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F (Molecular aspects of medicine 2013) 3 60

Products for SLC25A41 Gene

Sources for SLC25A41 Gene

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