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Aliases for SLC25A41 Gene

Aliases for SLC25A41 Gene

  • Solute Carrier Family 25 Member 41 2 3 5
  • Solute Carrier Family 25, Member 41 2 3
  • APC4 3

External Ids for SLC25A41 Gene

Previous GeneCards Identifiers for SLC25A41 Gene

  • GC19M006378
  • GC19M006186

Summaries for SLC25A41 Gene

Entrez Gene Summary for SLC25A41 Gene

  • SLC25A41 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC25A41 Gene

SLC25A41 (Solute Carrier Family 25 Member 41) is a Protein Coding gene. An important paralog of this gene is SLC25A42.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A41 Gene

Genomics for SLC25A41 Gene

Regulatory Elements for SLC25A41 Gene

Enhancers for SLC25A41 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC25A41 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A41 Gene

6,426,037 bp from pter
6,436,267 bp from pter
10,231 bases
Minus strand

Genomic View for SLC25A41 Gene

Genes around SLC25A41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A41 Gene

Proteins for SLC25A41 Gene

  • Protein details for SLC25A41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 25 member 41
    Protein Accession:
    Secondary Accessions:
    • A8MQ40
    • D6W642
    • Q8N7R4

    Protein attributes for SLC25A41 Gene

    370 amino acids
    Molecular mass:
    40795 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH31671.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC05163.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC25A41 Gene


neXtProt entry for SLC25A41 Gene

Proteomics data for SLC25A41 Gene at MOPED

Post-translational modifications for SLC25A41 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A41 Gene

No data available for DME Specific Peptides for SLC25A41 Gene

Domains & Families for SLC25A41 Gene

Gene Families for SLC25A41 Gene

Protein Domains for SLC25A41 Gene

Suggested Antigen Peptide Sequences for SLC25A41 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



S2541_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A41: view

Function for SLC25A41 Gene

Phenotypes for SLC25A41 Gene

genes like me logo Genes that share phenotypes with SLC25A41: view

Animal Model Products

CRISPR Products

miRNA for SLC25A41 Gene

miRTarBase miRNAs that target SLC25A41

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A41 Gene

Localization for SLC25A41 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A41 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC25A41 Gene COMPARTMENTS Subcellular localization image for SLC25A41 gene
Compartment Confidence
mitochondrion 4
cytosol 1
extracellular 1
golgi apparatus 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SLC25A41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with SLC25A41: view

Pathways & Interactions for SLC25A41 Gene

SuperPathways for SLC25A41 Gene

No Data Available

Interacting Proteins for SLC25A41 Gene

Gene Ontology (GO) - Biological Process for SLC25A41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A41: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A41 Gene

Drugs & Compounds for SLC25A41 Gene

No Compound Related Data Available

Transcripts for SLC25A41 Gene

mRNA/cDNA for SLC25A41 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC25A41 Gene

Solute carrier family 25, member 41:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A41 Gene

No ASD Table

Relevant External Links for SLC25A41 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC25A41 Gene

mRNA expression in normal human tissues for SLC25A41 Gene

mRNA differential expression in normal tissues according to GTEx for SLC25A41 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.5), Brain - Cerebellum (x6.0), Testis (x5.2), and Brain - Nucleus accumbens (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for SLC25A41 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC25A41 Gene

SOURCE GeneReport for Unigene cluster for SLC25A41 Gene Hs.375135

genes like me logo Genes that share expression patterns with SLC25A41: view

Protein tissue co-expression partners for SLC25A41 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SLC25A41 Gene

Orthologs for SLC25A41 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC25A41 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC25A23 35
  • 84.14 (n)
  • 85.53 (a)
SLC25A41 36
  • 77 (a)
(Canis familiaris)
Mammalia SLC25A41 35
  • 88.22 (n)
  • 89.13 (a)
SLC25A41 36
  • 76 (a)
(Mus musculus)
Mammalia Slc25a41 35
  • 84.44 (n)
  • 86.75 (a)
Slc25a41 16
Slc25a41 36
  • 85 (a)
(Pan troglodytes)
Mammalia SLC25A41 35
  • 98.74 (n)
  • 98.11 (a)
SLC25A41 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Slc25a41 35
  • 83.22 (n)
  • 86.75 (a)
(Monodelphis domestica)
Mammalia SLC25A41 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
(Danio rerio)
Actinopterygii si:ch211-196h16.11 36
  • 38 (a)
si:dkey-204f11.59 36
  • 39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32103 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea F17E5.2 36
  • 30 (a)
F55A11.4 36
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5381 36
  • 26 (a)
Species with no ortholog for SLC25A41:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC25A41 Gene

Gene Tree for SLC25A41 (if available)
Gene Tree for SLC25A41 (if available)

Paralogs for SLC25A41 Gene

Paralogs for SLC25A41 Gene

(4) SIMAP similar genes for SLC25A41 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC25A41: view

Variants for SLC25A41 Gene

Sequence variations from dbSNP and Humsavar for SLC25A41 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs34488963 - 6,430,095(-) AGGGC(A/G)GCTTC nc-transcript-variant, reference, missense
rs11883242 - 6,427,353(+) GGTCG(C/G)TGCAG nc-transcript-variant, reference, missense
rs12979402 -- 6,429,022(+) gaaaa(A/T)ttata intron-variant
rs8102808 -- 6,428,721(+) tatat(A/T)ttttt intron-variant
rs8103638 -- 6,430,634(+) aggct(A/C)gtgtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A41 Gene

Variant ID Type Subtype PubMed ID
dgv3698n71 CNV Loss 21882294
nsv910916 CNV Loss 21882294
nsv833727 CNV Loss 17160897
nsv910922 CNV Loss 21882294
nsv910923 CNV Loss 21882294

Variation tolerance for SLC25A41 Gene

Residual Variation Intolerance Score: 94.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.80; 73.71% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC25A41 Gene

Disorders for SLC25A41 Gene

Relevant External Links for SLC25A41

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC25A41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A41 Gene

Publications for SLC25A41 Gene

  1. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T. … Fredriksson R. (Genomics 2006) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F. (Mol. Aspects Med. 2013) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SLC25A41 Gene

Sources for SLC25A41 Gene