SLC25A40 Gene
protein-coding GIFtS: 46
GCID: GC07M087462
|
|
solute carrier family 25, member 40
| |
Aliases
for SLC25A40 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 25, Member 401 2 | | MCFP1 2 3 | | Mitochondrial Carrier Family Protein2 3 | | Solute Carrier Family 25 Member 402 |
Export aliases for SLC25A40 gene to outside databasesPrevious GC identifers: GC07M087304 GC07M082073 |
Summaries
for SLC25A40 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLC25A40:
SLC25A40 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 (PubMed16949250)).(supplied by OMIM, Mar 2008)
|
Genomic Views
for SLC25A40 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC25A40 gene promoter:
AP-1 POU3F1 Evi-1 YY1 GATA-1 CREB POU2F1a deltaCREB POU2F1b POU2F1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC25A40
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC25A40 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q21.12 Ensembl cytogenetic band: 7q21.12 HGNC cytogenetic band: 7q21.12SLC25A40 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M087462: view genomic region
(about GC identifiers)
Start:
|
87,462,883 bp from pter |
End:
|
87,505,692 bp from pter |
Size:
|
42,810 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 86,795,132-86,837,010 |
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Proteins
for SLC25A40 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S2540_HUMAN, Q8TBP6 (See
protein sequence)Recommended Name: Solute carrier family 25 member 40 Size: 338 amino acids; 38125 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: A8K483 D6W5P6 Q53GB1 Q9UHR1Explore the universe of human proteins at neXtProt for SLC25A40: NX_Q8TBP6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TBP6
SLC25A40 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061331.2
ENSEMBL proteins: ENSP00000344831 ENSP00000401473 ENSP00000405566 ENSP00000407780
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SLC25A40 for ontologies About GeneDecksing
SLC25A40 Antibody Products:
Assay Products for SLC25A40: |
Protein
Domains /
Families
for SLC25A40 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC25A40 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8TBP6ProtoNet protein and cluster: Q8TBP6 UniProtKB/Swiss-Prot: S2540_HUMAN, Q8TBP6Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) familySimilarity: Contains 3 Solcar repeats |
Function
for SLC25A40 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A40 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A40
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SLC25A40 (NM_018843) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC25A40 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A40 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A40 |
1 GenomeRNAi human phenotype for SLC25A40:
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Slc25a40):
SLC25A40 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SLC25A40 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC25A40
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0055085 | transmembrane transport |
IEA | -- |
SLC25A40 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC25A40 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC25A40
Search CenterWatch for drugs/clinical trials and news about SLC25A40 / S2540
|
Transcripts
for SLC25A40 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC25A40 gene: NM_018843.3 Unigene Cluster for SLC25A40: Solute carrier family 25, member 40 Hs.208414 [show with all ESTs]Unigene Representative Sequence: NM_0188438 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000341119(uc003uje.3) ENST00000446236 ENST00000496348 ENST00000429674
ENST00000470328 ENST00000483810 ENST00000444363 ENST00000491499
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A40 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A40
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLC25A40 (NM_018843) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC25A40 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A40 |
Additional cDNA sequence: AF125531.1 AK223020.1 AK290848.1 AL110179.1 BC027322.1 10 DOTS entries: DT.100778051 DT.100775582 DT.100817855 DT.455675 DT.121067462 DT.100778050 DT.121067472 DT.91869657 DT.102831892 DT.91665718 24/94 AceView cDNA sequences (see all 94): BM468921 BQ008206 BX393358 AW057637 AA721105 BM728631 AA912979 BX412894 BM795223 CD723698 AA465188 CR610506 AI037919 CR609204 AA411016 AA465546 CA309341 AI867011 AA401605 AA566144 BF109962 AL080033 AW440440 BX509288
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A40 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b |
|---|
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| SP1: | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SLC25A40
|
Expression
for SLC25A40 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC25A40 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACACAAAAGT
About this image
See SLC25A40 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC25A40
SOURCE GeneReport for Unigene cluster: Hs.208414
SABiosciences Custom PCR Arrays for SLC25A40
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC25A40
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC25A40 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC25A40 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC25A40 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A40 |
Orthologs
for SLC25A40 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC25A40 gene from 8/32 species (see all 32) About this table
ENSEMBL Gene Tree for SLC25A40 (if available)
TreeFam Gene Tree for SLC25A40 (if available) |
Paralogs
for SLC25A40 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC25A40 gene
- SLC25A392
1 SIMAP similar gene for SLC25A40 using alignment to 3 protein entries: S2540_HUMAN (see all proteins):SLC25A39
SLC25A40 for paralogs About GeneDecksing
|
Genomic Variants
for SLC25A40 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC25A40 (87462883 - 87505692 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC25A40: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC25A40 |
|
Disorders
/ Diseases
for SLC25A40 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC25A40 for disorders About GeneDecksing
OMIM gene information: 610821
OMIM disorders: --
5  diseases for SLC25A40: About MalaCardscerebrovascular accident sideroblastic anemia optic atrophy anemia
malaria
1 disease from the University of Copenhagen DISEASES database for SLC25A40:Sideroblastic anemia Human Genome Epidemiology (HuGE) Navigator: SLC25A40 (1 document)
Export disorders for SLC25A40 gene to outside databases
|
Publications
for SLC25A40 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC25A40 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC25A40) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PubMed id 16949250)1, 2, 3 Haitina T.... Fredriksson R. (2006)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
|
External Searches for SLC25A40 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC25A40 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC25A40 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC25A40 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC25A40 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC25A40 gene:
Search GeneIP for patents involving SLC25A40
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC25A40 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLC25A40 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC25A40 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC25A40 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLC25A40 | | OriGene 3'-UTR Clone for SLC25A40 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A40 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A40 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SLC25A40 | | OriGene Custom Protein Services for SLC25A40 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC25A40 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC25A40 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC25A40 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC25A40 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC25A40 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC25A40 |
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 | | | SLC25A40 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A40 |
|  |  |  | | | | Search ThermoFisher Antibodies for SLC25A40 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A40 |
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