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Aliases for SLC25A40 Gene

Aliases for SLC25A40 Gene

  • Solute Carrier Family 25 Member 40 2 3 5
  • Mitochondrial Carrier Family Protein 3 4
  • Solute Carrier Family 25, Member 40 2 3
  • MCFP 3 4

External Ids for SLC25A40 Gene

Previous GeneCards Identifiers for SLC25A40 Gene

  • GC07M087304
  • GC07M087462
  • GC07M082073

Summaries for SLC25A40 Gene

Entrez Gene Summary for SLC25A40 Gene

  • SLC25A40 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC25A40 Gene

SLC25A40 (Solute Carrier Family 25 Member 40) is a Protein Coding gene. An important paralog of this gene is SLC25A39.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A40 Gene

Genomics for SLC25A40 Gene

Regulatory Elements for SLC25A40 Gene

Enhancers for SLC25A40 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC25A40 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A40 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC25A40 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A40 Gene

Chromosome:
7
Start:
87,833,568 bp from pter
End:
87,876,377 bp from pter
Size:
42,810 bases
Orientation:
Minus strand

Genomic View for SLC25A40 Gene

Genes around SLC25A40 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A40 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A40 Gene

Proteins for SLC25A40 Gene

  • Protein details for SLC25A40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBP6-S2540_HUMAN
    Recommended name:
    Solute carrier family 25 member 40
    Protein Accession:
    Q8TBP6
    Secondary Accessions:
    • A8K483
    • D6W5P6
    • Q53GB1
    • Q9UHR1

    Protein attributes for SLC25A40 Gene

    Size:
    338 amino acids
    Molecular mass:
    38125 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC25A40 Gene

Proteomics data for SLC25A40 Gene at MOPED

Post-translational modifications for SLC25A40 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A40 Gene

No data available for DME Specific Peptides for SLC25A40 Gene

Domains & Families for SLC25A40 Gene

Gene Families for SLC25A40 Gene

HGNC:
IUPHAR :

Protein Domains for SLC25A40 Gene

Suggested Antigen Peptide Sequences for SLC25A40 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TBP6

UniProtKB/Swiss-Prot:

S2540_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A40: view

Function for SLC25A40 Gene

genes like me logo Genes that share phenotypes with SLC25A40: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A40

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A40 Gene

Localization for SLC25A40 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A40 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A40 Gene COMPARTMENTS Subcellular localization image for SLC25A40 gene
Compartment Confidence
mitochondrion 4
peroxisome 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC25A40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with SLC25A40: view

Pathways & Interactions for SLC25A40 Gene

SuperPathways for SLC25A40 Gene

No Data Available

Interacting Proteins for SLC25A40 Gene

Gene Ontology (GO) - Biological Process for SLC25A40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A40: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A40 Gene

Drugs & Compounds for SLC25A40 Gene

No Compound Related Data Available

Transcripts for SLC25A40 Gene

Unigene Clusters for SLC25A40 Gene

Solute carrier family 25, member 40:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A40 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - -
SP2: -
SP3: - -
SP4:

Relevant External Links for SLC25A40 Gene

GeneLoc Exon Structure for
SLC25A40
ECgene alternative splicing isoforms for
SLC25A40

Expression for SLC25A40 Gene

mRNA expression in normal human tissues for SLC25A40 Gene

Protein differential expression in normal tissues from HIPED for SLC25A40 Gene

This gene is overexpressed in Breast (9.5), Bone (7.1), and Stomach (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SLC25A40 Gene



SOURCE GeneReport for Unigene cluster for SLC25A40 Gene Hs.208414

genes like me logo Genes that share expression patterns with SLC25A40: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SLC25A40 Gene

Orthologs for SLC25A40 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A40 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC25A40 35
  • 91.42 (n)
  • 89.64 (a)
SLC25A40 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A40 35
  • 91.81 (n)
  • 91.12 (a)
SLC25A40 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a40 35
  • 86.61 (n)
  • 83.33 (a)
Slc25a40 16
Slc25a40 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC25A40 35
  • 99.7 (n)
  • 99.7 (a)
SLC25A40 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a40 35
  • 84.03 (n)
  • 80.91 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC25A40 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A40 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC25A40 35
  • 68.97 (n)
  • 61.26 (a)
SLC25A40 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC25A40 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76123 35
slc25a40 35
  • 64.24 (n)
  • 63.83 (a)
zebrafish
(Danio rerio)
Actinopterygii slc25a40 35
  • 63.58 (n)
  • 66.36 (a)
slc25a40 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001297 35
  • 51.24 (n)
  • 50.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta Shawn 35
  • 50.83 (n)
  • 48.14 (a)
CG2616 36
  • 33 (a)
ManyToMany
Shawn 36
  • 40 (a)
ManyToMany
Tyler 36
  • 29 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_C16C10.1 35
  • 54.47 (n)
  • 51.1 (a)
C16C10.1 36
  • 45 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR131C 35
  • 48.24 (n)
  • 40.26 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A09383g 35
  • 49.46 (n)
  • 41.56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTM1 35
  • 49.56 (n)
  • 39.87 (a)
MTM1 36
  • 28 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G46320 35
  • 44.69 (n)
  • 35.91 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07478 35
  • 47.33 (n)
  • 43.83 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBP23A10.06 35
  • 45.8 (n)
  • 39.86 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2166 35
Species with no ortholog for SLC25A40:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A40 Gene

ENSEMBL:
Gene Tree for SLC25A40 (if available)
TreeFam:
Gene Tree for SLC25A40 (if available)

Paralogs for SLC25A40 Gene

Paralogs for SLC25A40 Gene

(1) SIMAP similar genes for SLC25A40 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC25A40: view

Variants for SLC25A40 Gene

Sequence variations from dbSNP and Humsavar for SLC25A40 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs724665 - 87,847,942(+) AGCAG(A/G)TAAAA nc-transcript-variant, reference, missense
rs3213633 - 87,847,024(-) GCAAG(A/C)AAGTA nc-transcript-variant, reference, missense
rs1012577 -- 87,870,155(-) actca(A/G)taaga intron-variant
rs6952738 -- 87,869,045(+) aatat(A/G)tattt intron-variant
rs12704373 -- 87,857,648(+) gtctt(A/T)cttta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A40 Gene

Variant ID Type Subtype PubMed ID
nsv888677 CNV Gain 21882294
nsv464622 CNV Gain 19166990
esv2734777 CNV Deletion 23290073

Variation tolerance for SLC25A40 Gene

Residual Variation Intolerance Score: 60% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.61; 45.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A40 Gene

HapMap Linkage Disequilibrium report
SLC25A40
Human Gene Mutation Database (HGMD)
SLC25A40

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A40 Gene

Disorders for SLC25A40 Gene

Relevant External Links for SLC25A40

Genetic Association Database (GAD)
SLC25A40
Human Genome Epidemiology (HuGE) Navigator
SLC25A40
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A40

No disorders were found for SLC25A40 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A40 Gene

Publications for SLC25A40 Gene

  1. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T. … Fredriksson R. (Genomics 2006) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F. (Mol. Aspects Med. 2013) 3
  4. Joint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia. (PMID: 24268658) Rosenthal E.A. … Jarvik G.P. (Am. J. Hum. Genet. 2013) 3
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3

Products for SLC25A40 Gene

Sources for SLC25A40 Gene

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