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Aliases for SLC25A40 Gene

Aliases for SLC25A40 Gene

  • Solute Carrier Family 25, Member 40 2 3
  • Mitochondrial Carrier Family Protein 3 4
  • MCFP 3 4
  • Solute Carrier Family 25 Member 40 3

External Ids for SLC25A40 Gene

Summaries for SLC25A40 Gene

Entrez Gene Summary for SLC25A40 Gene

  • SLC25A40 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC25A40 Gene

SLC25A40 (Solute Carrier Family 25, Member 40) is a Protein Coding gene. An important paralog of this gene is SLC25A39.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A40 Gene

Genomics for SLC25A40 Gene

Genomic Location for SLC25A40 Gene

Start:
87,833,561 bp from pter
End:
87,876,377 bp from pter
Size:
42,817 bases
Orientation:
Minus strand

Genomic View for SLC25A40 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC25A40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A40 Gene

Regulatory Elements for SLC25A40 Gene

Proteins for SLC25A40 Gene

  • Protein details for SLC25A40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBP6-S2540_HUMAN
    Recommended name:
    Solute carrier family 25 member 40
    Protein Accession:
    Q8TBP6
    Secondary Accessions:
    • A8K483
    • D6W5P6
    • Q53GB1
    • Q9UHR1

    Protein attributes for SLC25A40 Gene

    Size:
    338 amino acids
    Molecular mass:
    38125 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC25A40 Gene

Proteomics data for SLC25A40 Gene at MOPED

Post-translational modifications for SLC25A40 Gene

No Post-translational modifications

Other Protein References for SLC25A40 Gene

No data available for DME Specific Peptides for SLC25A40 Gene

Domains for SLC25A40 Gene

Gene Families for SLC25A40 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC25A40 Gene

UniProtKB/Swiss-Prot:

S2540_HUMAN
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.:
    • Q8TBP6
Similarity:
  • Contains 3 Solcar repeats.:
    • Q8TBP6
genes like me logo Genes that share domains with SLC25A40: view

Function for SLC25A40 Gene

Phenotypes for SLC25A40 Gene

MGI mutant phenotypes for SLC25A40:
inferred from 1 alleles
GenomeRNAi human phenotypes for SLC25A40:
genes like me logo Genes that share phenotypes with SLC25A40: view

miRNA for SLC25A40 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC25A40 Gene

Localization for SLC25A40 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A40 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A40 Gene COMPARTMENTS Subcellular localization image for SLC25A40 gene
Compartment Confidence
mitochondrion 5
peroxisome 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC25A40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC25A40: view

Pathways for SLC25A40 Gene

SuperPathways for SLC25A40 Gene

No Data Available

Interacting Proteins for SLC25A40 Gene

Gene Ontology (GO) - Biological Process for SLC25A40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A40: view

No data available for Pathways by source for SLC25A40 Gene

Transcripts for SLC25A40 Gene

Unigene Clusters for SLC25A40 Gene

Solute carrier family 25, member 40:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A40 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - -
SP2: -
SP3: - -
SP4:

Relevant External Links for SLC25A40 Gene

GeneLoc Exon Structure for
SLC25A40
ECgene alternative splicing isoforms for
SLC25A40

Expression for SLC25A40 Gene

mRNA expression in normal human tissues for SLC25A40 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC25A40 Gene

SOURCE GeneReport for Unigene cluster for SLC25A40 Gene Hs.208414

genes like me logo Genes that share expressions with SLC25A40: view

Orthologs for SLC25A40 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A40 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A40 36
  • 99.7 (n)
  • 99.7 (a)
SLC25A40 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC25A40 36
  • 91.42 (n)
  • 89.64 (a)
SLC25A40 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A40 36
  • 91.81 (n)
  • 91.12 (a)
SLC25A40 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a40 36
  • 86.61 (n)
  • 83.33 (a)
Slc25a40 16
Slc25a40 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC25A40 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A40 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a40 36
  • 84.03 (n)
  • 80.91 (a)
chicken
(Gallus gallus)
Aves SLC25A40 36
  • 68.97 (n)
  • 61.26 (a)
SLC25A40 37
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC25A40 37
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76123 36
slc25a40 36
  • 64.24 (n)
  • 63.83 (a)
zebrafish
(Danio rerio)
Actinopterygii slc25a40 36
  • 63.58 (n)
  • 66.36 (a)
slc25a40 37
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001297 36
  • 51.24 (n)
  • 50.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2616 37
  • 33 (a)
ManyToMany
Shawn 36
  • 50.83 (n)
  • 48.14 (a)
Shawn 37
  • 40 (a)
ManyToMany
Tyler 37
  • 29 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C16C10.1 37
  • 45 (a)
OneToMany
CELE_C16C10.1 36
  • 54.47 (n)
  • 51.1 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR131C 36
  • 48.24 (n)
  • 40.26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTM1 36
  • 49.56 (n)
  • 39.87 (a)
MTM1 37
  • 28 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A09383g 36
  • 49.46 (n)
  • 41.56 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G46320 36
  • 44.69 (n)
  • 35.91 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07478 36
  • 47.33 (n)
  • 43.83 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBP23A10.06 36
  • 45.8 (n)
  • 39.86 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2166 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 47 (a)
OneToMany
Species with no ortholog for SLC25A40:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A40 Gene

ENSEMBL:
Gene Tree for SLC25A40 (if available)
TreeFam:
Gene Tree for SLC25A40 (if available)

Paralogs for SLC25A40 Gene

Paralogs for SLC25A40 Gene

Selected SIMAP similar genes for SLC25A40 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC25A40: view

Variants for SLC25A40 Gene

Sequence variations from dbSNP and Humsavar for SLC25A40 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs724664 -- 87,848,236(+) TACAA(C/T)AAATA intron-variant
rs724665 - 87,847,942(+) AGCAG(A/G)TAAAA reference, missense, nc-transcript-variant
rs1012577 -- 87,870,155(-) actca(A/G)taaga intron-variant
rs2040634 -- 87,859,359(-) gttca(C/T)gccat intron-variant
rs2097716 -- 87,855,494(-) TGGCA(A/C)CAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A40 Gene

Variant ID Type Subtype PubMed ID
nsv888677 CNV Gain 21882294
nsv464622 CNV Gain 19166990
esv2734777 CNV Deletion 23290073

Relevant External Links for SLC25A40 Gene

HapMap Linkage Disequilibrium report
SLC25A40
Human Gene Mutation Database (HGMD)
SLC25A40

Disorders for SLC25A40 Gene

Relevant External Links for SLC25A40

Genetic Association Database (GAD)
SLC25A40
Human Genome Epidemiology (HuGE) Navigator
SLC25A40
genes like me logo Genes that share disorders with SLC25A40: view

No data available for UniProtKB/Swiss-Prot for SLC25A40 Gene

Publications for SLC25A40 Gene

  1. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T. … Fredriksson R. (Genomics 2006) 2 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  4. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F. (Mol. Aspects Med. 2013) 3
  5. Joint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia. (PMID: 24268658) Rosenthal E.A. … Jarvik G.P. (Am. J. Hum. Genet. 2013) 3

Products for SLC25A40 Gene

Sources for SLC25A40 Gene

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