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Aliases for SLC25A4 Gene

Aliases for SLC25A4 Gene

  • Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 4 2 3
  • ANT1 3 4 6
  • Solute Carrier Family 25 Member 4 3 4
  • ADP,ATP Carrier Protein 1 3 4
  • MTDPS12 3 6
  • ANT 1 3 4
  • PEO2 3 6
  • PEO3 3 6
  • T1 3 6
  • ADP,ATP Carrier Protein, Heart/Skeletal Muscle Isoform T1 4
  • Adenine Nucleotide Translocator 1 (Skeletal Muscle) 3
  • ADP,ATP Carrier Protein, Heart/Skeletal Muscle 3
  • Heart/Skeletal Muscle ATP/ADP Translocator 3
  • Adenine Nucleotide Translocator 1 4
  • ADP/ATP Translocase 1 3
  • AAC1 3
  • ANT 3
  • 1 3

External Ids for SLC25A4 Gene

Previous HGNC Symbols for SLC25A4 Gene

  • PEO3
  • PEO2
  • ANT1

Previous GeneCards Identifiers for SLC25A4 Gene

  • GC04P187100
  • GC04P186744
  • GC04P186648
  • GC04P186760
  • GC04P186439
  • GC04P186301
  • GC04P186064
  • GC04P181818

Summaries for SLC25A4 Gene

Entrez Gene Summary for SLC25A4 Gene

  • This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. [provided by RefSeq, Jun 2013]

GeneCards Summary for SLC25A4 Gene

SLC25A4 (Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 4) is a Protein Coding gene. Diseases associated with SLC25A4 include mitochondrial dna depletion syndrome 12 and progressive external ophthalmoplegia with mitochondrial dna deletions 3. Among its related pathways are Disease and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include adenine transmembrane transporter activity. An important paralog of this gene is SLC25A5.

UniProtKB/Swiss-Prot for SLC25A4 Gene

  • Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane

Gene Wiki entry for SLC25A4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A4 Gene

Genomics for SLC25A4 Gene

Regulatory Elements for SLC25A4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC25A4 Gene

185,143,241 bp from pter
185,150,384 bp from pter
7,144 bases
Plus strand

Genomic View for SLC25A4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC25A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A4 Gene

Proteins for SLC25A4 Gene

  • Protein details for SLC25A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP/ATP translocase 1
    Protein Accession:
    Secondary Accessions:
    • D3DP59

    Protein attributes for SLC25A4 Gene

    298 amino acids
    Molecular mass:
    33064 Da
    Quaternary structure:
    • Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with ARL2BP (By similarity). Homodimer. Interacts with HIV-1 Vpr.
    • The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).

neXtProt entry for SLC25A4 Gene

Proteomics data for SLC25A4 Gene at MOPED

Post-translational modifications for SLC25A4 Gene

  • Ubiquitination at Lys43, Lys63, Lys245, and Lys272
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC25A4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A4 Gene

Domains for SLC25A4 Gene

Suggested Antigen Peptide Sequences for SLC25A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P12235
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A4: view

Function for SLC25A4 Gene

Molecular function for SLC25A4 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane

Gene Ontology (GO) - Molecular Function for SLC25A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005515 protein binding IPI 16507998
GO:0015207 adenine transmembrane transporter activity TAS 2823266
genes like me logo Genes that share ontologies with SLC25A4: view
genes like me logo Genes that share phenotypes with SLC25A4: view

Animal Models for SLC25A4 Gene

MGI Knock Outs for SLC25A4:

Animal Model Products

CRISPR Products

miRNA for SLC25A4 Gene

miRTarBase miRNAs that target SLC25A4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC25A4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC25A4 Gene

Localization for SLC25A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A4 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC25A4 Gene COMPARTMENTS Subcellular localization image for SLC25A4 gene
Compartment Confidence
mitochondrion 5
plasma membrane 4
cytosol 2
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC25A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA 20833797
GO:0005743 mitochondrial inner membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2823266
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC25A4: view

Pathways for SLC25A4 Gene

genes like me logo Genes that share pathways with SLC25A4: view

Pathways by source for SLC25A4 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for SLC25A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000002 mitochondrial genome maintenance TAS 10926541
GO:0006091 generation of precursor metabolites and energy TAS 2823266
GO:0006112 energy reserve metabolic process TAS --
GO:0006810 transport TAS 2823266
GO:0008637 apoptotic mitochondrial changes IEA --
genes like me logo Genes that share ontologies with SLC25A4: view

Compounds for SLC25A4 Gene

(6) Drugbank Compounds for SLC25A4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine triphosphate
  • 5'-ATP
56-65-5 target
33286-30-5 target
  • CDL
10596-23-3 target inhibitor

(2) IUPHAR Ligand for SLC25A4 Gene

Ligand Type Action Affinity Pubmed IDs
carboxyatractyloside Inhibitor Inhibition
bongkrek acid Inhibitor Inhibition

(16) Novoseek inferred chemical compound relationships for SLC25A4 Gene

Compound -log(P) Hits PubMed IDs
ptpc 80.8 4
adp 75.8 34
carboxyatractyloside 72.2 2
mptp 69.9 15
bongkrekic acid 66.8 1
genes like me logo Genes that share compounds with SLC25A4: view

Transcripts for SLC25A4 Gene

mRNA/cDNA for SLC25A4 Gene

(256) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC25A4 Gene

Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC25A4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A4 Gene

No ASD Table

Relevant External Links for SLC25A4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC25A4 Gene

mRNA expression in normal human tissues for SLC25A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A4 Gene

This gene is overexpressed in Heart - Left Ventricle (15.6), Muscle - Skeletal (8.6), and Heart - Atrial Appendage (8.5).

Protein differential expression in normal tissues for SLC25A4 Gene

This gene is overexpressed in Heart (32.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A4 Gene

SOURCE GeneReport for Unigene cluster for SLC25A4 Gene Hs.246506

genes like me logo Genes that share expressions with SLC25A4: view

Expression partners for SLC25A4 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLC25A4 Gene

Orthologs for SLC25A4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC25A4 35
  • 92.73 (n)
  • 95.97 (a)
SLC25A4 36
  • 96 (a)
(Canis familiaris)
Mammalia SLC25A4 35
  • 90.38 (n)
  • 94.3 (a)
SLC25A4 36
  • 94 (a)
(Mus musculus)
Mammalia Slc25a4 35
  • 91.28 (n)
  • 95.3 (a)
Slc25a4 16
Slc25a4 36
  • 95 (a)
(Pan troglodytes)
Mammalia SLC25A4 35
  • 97.43 (n)
  • 97.32 (a)
SLC25A4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slc25a4 35
  • 91.72 (n)
  • 95.64 (a)
(Monodelphis domestica)
Mammalia SLC25A4 36
  • 88 (a)
(Gallus gallus)
Aves SLC25A4 35
  • 83.45 (n)
  • 93.62 (a)
SLC25A4 36
  • 94 (a)
(Anolis carolinensis)
Reptilia SLC25A4 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75662 35
slc25a4 35
  • 79.64 (n)
  • 89.6 (a)
(Danio rerio)
Actinopterygii slc25a4 35
  • 77.52 (n)
  • 88.59 (a)
slc25a4 36
  • 89 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ant2 37
  • 73 (a)
sesB 37
  • 79 (a)
sesB 35
  • 74 (n)
  • 81.1 (a)
Ant2 36
  • 72 (a)
sesB 36
  • 76 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta ADT2_ANOGA 35
  • 72.76 (n)
  • 79.31 (a)
(Caenorhabditis elegans)
Secernentea C47E12.2 37
  • 50 (a)
F25B4.7 37
  • 47 (a)
K01H12.2 37
  • 69 (a)
R07E3.4 37
  • 44 (a)
T01B11.4 37
  • 69 (a)
W02D3.6 37
  • 65 (a)
ant-1.4 36
  • 65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAC1 36
  • 51 (a)
AAC3 36
  • 50 (a)
PET9 36
  • 49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2354 36
  • 52 (a)
Species with no ortholog for SLC25A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A4 Gene

Gene Tree for SLC25A4 (if available)
Gene Tree for SLC25A4 (if available)

Paralogs for SLC25A4 Gene

Paralogs for SLC25A4 Gene

Selected SIMAP similar genes for SLC25A4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC25A4: view

Variants for SLC25A4 Gene

Sequence variations from dbSNP and Humsavar for SLC25A4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1042560 -- 185,144,824(+) ATTGT(G/T)TGGTG reference, missense
rs1800396 -- 185,146,356(+) CCATA(C/T)GAAAT intron-variant
rs1804551 -- 185,147,104(+) AATAC(C/T)TCAGA utr-variant-3-prime
rs2046535 -- 185,149,278(+) CCTGA(C/T)ACAAT utr-variant-3-prime
rs3733651 -- 185,143,265(+) GGCGG(C/T)GGCCC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC25A4 Gene

Variant ID Type Subtype PubMed ID
nsv461859 CNV Loss 19166990

Relevant External Links for SLC25A4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A4 Gene

Disorders for SLC25A4 Gene

(2) OMIM Diseases for SLC25A4 Gene (103220)


  • Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 2 (PEOA2) [MIM:609283]: A disorder characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism. {ECO:0000269 PubMed:10926541, ECO:0000269 PubMed:11756613, ECO:0000269 PubMed:12112115, ECO:0000269 PubMed:15792871, ECO:0000269 PubMed:18575922}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Mitochondrial DNA depletion syndrome 12, cardiomyopathic type (MTDPS12) [MIM:615418]: An autosomal recessive mitochondrial disorder characterized by childhood onset of slowly progressive hypertrophic cardiomyopathy and generalized skeletal myopathy resulting in exercise intolerance and, in some patients, muscle weakness and atrophy. Skeletal muscle biopsy shows ragged red fibers, mtDNA depletion, and accumulation of abnormal mitochondria. {ECO:0000269 PubMed:22187496}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for SLC25A4 Gene

(11) Novoseek inferred disease relationships for SLC25A4 Gene

Disease -log(P) Hits PubMed IDs
progressive external ophthalmoplegia 91.8 7
sengers syndrome 88.2 1
muscular dystrophy facioscapulohumeral 80.7 1
mitochondrial diseases 76.2 2
mitochondrial myopathies 70.1 1

Relevant External Links for SLC25A4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLC25A4: view

No data available for Genatlas for SLC25A4 Gene

Publications for SLC25A4 Gene

  1. Novel Twinkle (PEO1) gene mutations in Mendelian progressive external ophthalmoplegia. (PMID: 18575922) Virgilio R. … Comi G.P. (J. Neurol. 2008) 3 4 23 48
  2. Assignment of the human muscle adenine nucleotide translocator gene (ANT1) to 4q35 by fluorescence in situ hybridization. (PMID: 1582253) Fan Y.S. … Lin C.C. (Cytogenet. Cell Genet. 1992) 2 3 23
  3. A novel missense adenine nucleotide translocator-1 gene mutation in a Greek adPEO family. (PMID: 11756613) Napoli L. … Comi G.P. (Neurology 2001) 3 4 23
  4. A novel ANT1 gene mutation with probable germline mosaicism in autosomal dominant progressive external ophthalmoplegia. (PMID: 15792871) Deschauer M. … Zierz S. (Neuromuscul. Disord. 2005) 3 4 23
  5. Recruitment of NF-kappaB into mitochondria is involved in adenine nucleotide translocase 1 (ANT1)-induced apoptosis. (PMID: 15231833) Zamora M. … Mampel T. (J. Biol. Chem. 2004) 3 23

Products for SLC25A4 Gene

Sources for SLC25A4 Gene

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