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Aliases for SLC25A39 Gene

Aliases for SLC25A39 Gene

  • Solute Carrier Family 25, Member 39 2 3
  • CGI69 3 6
  • Solute Carrier Family 25 Member 39 3
  • CGI-69 3

External Ids for SLC25A39 Gene

Previous GeneCards Identifiers for SLC25A39 Gene

  • GC17M039753
  • GC17M042396
  • GC17M038161

Summaries for SLC25A39 Gene

Entrez Gene Summary for SLC25A39 Gene

  • SLC25A39 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC25A39 Gene

SLC25A39 (Solute Carrier Family 25, Member 39) is a Protein Coding gene. An important paralog of this gene is SLC25A40.

UniProtKB/Swiss-Prot for SLC25A39 Gene

  • Required for normal heme biosynthesis.

Gene Wiki entry for SLC25A39 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A39 Gene

Genomics for SLC25A39 Gene

Regulatory Elements for SLC25A39 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC25A39 Gene

Start:
44,319,625 bp from pter
End:
44,324,870 bp from pter
Size:
5,246 bases
Orientation:
Minus strand

Genomic View for SLC25A39 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC25A39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A39 Gene

Proteins for SLC25A39 Gene

  • Protein details for SLC25A39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZJ4-S2539_HUMAN
    Recommended name:
    Solute carrier family 25 member 39
    Protein Accession:
    Q9BZJ4
    Secondary Accessions:
    • A8JZZ2
    • D3DX51
    • D3DX54
    • Q4V9M1
    • Q9P182
    • Q9UF66
    • Q9Y379

    Protein attributes for SLC25A39 Gene

    Size:
    359 amino acids
    Molecular mass:
    39249 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF69618.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC25A39 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A39 Gene

Proteomics data for SLC25A39 Gene at MOPED

Post-translational modifications for SLC25A39 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for SLC25A39 Gene

Domains for SLC25A39 Gene

Gene Families for SLC25A39 Gene

Protein Domains for SLC25A39 Gene

Suggested Antigen Peptide Sequences for SLC25A39 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZJ4

UniProtKB/Swiss-Prot:

S2539_HUMAN :
  • Q9BZJ4
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A39: view

Function for SLC25A39 Gene

Molecular function for SLC25A39 Gene

UniProtKB/Swiss-Prot Function:
Required for normal heme biosynthesis.

Phenotypes for SLC25A39 Gene

GenomeRNAi human phenotypes for SLC25A39:
genes like me logo Genes that share phenotypes with SLC25A39: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC25A39

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC25A39 Gene

Localization for SLC25A39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A39 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A39 Gene COMPARTMENTS Subcellular localization image for SLC25A39 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for SLC25A39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC25A39: view

Pathways for SLC25A39 Gene

SuperPathways for SLC25A39 Gene

No Data Available

Interacting Proteins for SLC25A39 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366299%0d%0a9606.ENSP00000306330%0d%0a9606.ENSP00000340989%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000366299 Q9BZJ4-S2539_HUMAN for SLC25A39 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLC25A39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006783 heme biosynthetic process IEA --
GO:0006810 transport IEA --
GO:0055085 transmembrane transport --
genes like me logo Genes that share ontologies with SLC25A39: view

No data available for Pathways by source for SLC25A39 Gene

Transcripts for SLC25A39 Gene

Unigene Clusters for SLC25A39 Gene

Solute carrier family 25, member 39:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC25A39

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A39 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - -
SP11: - - - - -
SP12: - - - - - - - -
SP13: - - - - - - - - - - - - -
SP14: - - - - -
SP15: - -
SP16: - -
SP17: - - - - - - - - - -
SP18: - -
SP19:
SP20: - - - - - - - - - - - - - - - - - - - - - -
SP21:
SP22: - - - - -
SP23:
SP24: - - - - -

ExUns: 8f ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - -
SP2: - -
SP3: -
SP4: - -
SP5: -
SP6:
SP7:
SP8: -
SP9: -
SP10: -
SP11: - -
SP12:
SP13: -
SP14: -
SP15: -
SP16: - - - -
SP17:
SP18: - -
SP19:
SP20: - -
SP21: - - - - - -
SP22:
SP23:
SP24:

Relevant External Links for SLC25A39 Gene

GeneLoc Exon Structure for
SLC25A39
ECgene alternative splicing isoforms for
SLC25A39

Expression for SLC25A39 Gene

mRNA expression in normal human tissues for SLC25A39 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A39 Gene

This gene is overexpressed in Whole Blood (19.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC25A39 Gene

SOURCE GeneReport for Unigene cluster for SLC25A39 Gene Hs.744880

mRNA Expression by UniProt/SwissProt for SLC25A39 Gene

Q9BZJ4-S2539_HUMAN
Tissue specificity: Expressed in many tissues. Abundant in testis and kidney.
genes like me logo Genes that share expressions with SLC25A39: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Expression partners for SLC25A39 Gene

Orthologs for SLC25A39 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A39 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC25A39 35
  • 88.92 (n)
  • 92.26 (a)
SLC25A39 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A39 35
  • 89.85 (n)
  • 94.13 (a)
-- 36
  • 94 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Slc25a39 35
  • 85.94 (n)
  • 88.55 (a)
Slc25a39 16
Slc25a39 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC25A39 35
  • 99.44 (n)
  • 98.89 (a)
SLC25A39 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a39 35
  • 85.66 (n)
  • 88.27 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC25A39 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC25A39 35
  • 69.71 (n)
  • 65.24 (a)
SLC25A39 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC25A39 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a39 35
  • 61.96 (n)
  • 60.23 (a)
Str.3014 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.2727 35
zebrafish
(Danio rerio)
Actinopterygii slc25a39 35
  • 63.14 (n)
  • 59.41 (a)
zgc63736 35
slc25a39 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2616 36
  • 33 (a)
ManyToMany
Shawn 36
  • 38 (a)
ManyToMany
Tyler 36
  • 29 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C16C10.1 36
  • 40 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTM1 36
  • 27 (a)
OneToMany
MTM1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons MTM1 35
  • 45.81 (n)
  • 37.11 (a)
rice
(Oryza sativa)
Liliopsida Os08g0386800 35
  • 48.22 (n)
  • 40.88 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for SLC25A39:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A39 Gene

ENSEMBL:
Gene Tree for SLC25A39 (if available)
TreeFam:
Gene Tree for SLC25A39 (if available)

Paralogs for SLC25A39 Gene

Paralogs for SLC25A39 Gene

Selected SIMAP similar genes for SLC25A39 Gene using alignment to 10 proteins:

Pseudogenes.org Pseudogenes for SLC25A39 Gene

genes like me logo Genes that share paralogs with SLC25A39: view

Variants for SLC25A39 Gene

Sequence variations from dbSNP and Humsavar for SLC25A39 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1059555 -- 44,324,751(-) GCCTG(A/G)CCCTG utr-variant-5-prime
rs1059658 -- 44,319,853(-) TCCCT(C/T)TGGGC utr-variant-3-prime
rs1059689 -- 44,319,759(-) CAAAT(C/T)TTCCA utr-variant-3-prime
rs1551361 -- 44,321,998(-) tgctg(A/G)ctggg intron-variant
rs2011895 -- 44,321,389(-) ACCTC(G/T)GCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A39 Gene

Variant ID Type Subtype PubMed ID
nsv908270 CNV Loss 21882294
nsv510713 CNV Loss 20534489
nsv908275 CNV Loss 21882294
dgv3175n71 CNV Loss 21882294
nsv908278 CNV Loss 21882294
nsv2061 CNV Insertion 18451855

Relevant External Links for SLC25A39 Gene

HapMap Linkage Disequilibrium report
SLC25A39
Human Gene Mutation Database (HGMD)
SLC25A39

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A39 Gene

Disorders for SLC25A39 Gene

Relevant External Links for SLC25A39

Genetic Association Database (GAD)
SLC25A39
Human Genome Epidemiology (HuGE) Navigator
SLC25A39

No disorders were found for SLC25A39 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SLC25A39 Gene

Publications for SLC25A39 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4
  2. Overexpression of the human 2-oxoglutarate carrier lowers mitochondrial membrane potential in HEK-293 cells: contrast with the unique cold-induced mitochondrial carrier CGI-69. (PMID: 11139402) Yu X.X. … Adams S.H. (Biochem. J. 2001) 3 4
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PMID: 11256614) Simpson J.C. … Wiemann S. (EMBO Rep. 2000) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for SLC25A39 Gene

Sources for SLC25A39 Gene

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