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SLC25A37 Gene

protein-coding   GIFtS: 57
GCID: GC08P023386

Solute Carrier Family 25 (Mitochondrial Iron Transporter),...

(Previous names: solute carrier family 25, member 37)
  See SLC25A37-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 25 (Mitochondrial Iron Transporter), Member
371 2
     MSC2
MFRN2 3 5     PRO12782
Solute Carrier Family 25, Member 371 2     PRO15842
mitoferrin1 2     PRO22172
Mitochondrial Iron Transporter 12 3     mitoferrin-12
Mitochondrial Solute Carrier Protein2 3     Predicted Protein Of HQ22172
MSCP2 3     Solute Carrier Family 25 Member 373
MFRN12 5     

External Ids:    HGNC: 297861   Entrez Gene: 513122   Ensembl: ENSG000001474547   OMIM: 6103875   UniProtKB: Q9NYZ23   

Export aliases for SLC25A37 gene to outside databases

Previous GC identifers: GC08P023443 GC08P023444 GC08P021931


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC25A37 Gene:
SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron
importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009 (PubMed
19805291)).(supplied by OMIM, Jan 2011)

GeneCards Summary for SLC25A37 Gene:
SLC25A37 (solute carrier family 25 (mitochondrial iron transporter), member 37) is a protein-coding gene. Diseases associated with SLC25A37 include erythropoietic protoporphyria. GO annotations related to this gene include iron ion transmembrane transporter activity. An important paralog of this gene is SLC25A28.

UniProtKB/Swiss-Prot: MFRN1_HUMAN, Q9NYZ2
Function: Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells,
thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as
Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to
make heme (By similarity)

Gene Wiki entry for SLC25A37 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC25A37 gene promoter:
         Max1   AML1a   MyoD   Meis-1b   SEF-1 (1)   ARP-1   Meis-1a   Pax-4a   Meis-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC25A37 promoter sequence
   Search Chromatin IP Primers for SLC25A37

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC25A37


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.2   Ensembl cytogenetic band:  8p21.2   HGNC cytogenetic band: 8p21.2

SLC25A37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A37 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P023386:  view genomic region     (about GC identifiers)

Start:
23,386,318 bp from pter      End:
23,432,976 bp from pter
Size:
46,659 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MFRN1_HUMAN, Q9NYZ2 (See protein sequence)
Recommended Name: Mitoferrin-1  
Size: 338 amino acids; 37323 Da
Sequence caution: Sequence=AAF64141.1; Type=Frameshift; Positions=296; Sequence=CAH10415.1; Type=Erroneous
translation; Note=Wrong choice of CDS;
Secondary accessions: A2RU93 Q53FT7 Q69YJ8 Q969S1 Q9P0J2
Alternative splicing: 3 isoforms:  Q9NYZ2-1   Q9NYZ2-2   Q9NYZ2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC25A37: NX_Q9NYZ2

Explore proteomics data for SLC25A37 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC25A37 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057696.2  
    ENSEMBL proteins: 
     ENSP00000429200   ENSP00000402782   ENSP00000290075   ENSP00000428066  
    Reactome Protein details: Q9NYZ2

    SLC25A37 Human Recombinant Protein Products:

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    Novus Biologicals SLC25A37 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for SLC25A37 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Mitoferrin1
    Miscellaneous SLC25 mitochondrial transporters

    2 InterPro protein domains:
     IPR023395 Mt_carrier_dom
     IPR018108 Mitochondrial_sb/sol_carrier

    Graphical View of Domain Structure for InterPro Entry Q9NYZ2

    ProtoNet protein and cluster: Q9NYZ2

    UniProtKB/Swiss-Prot: MFRN1_HUMAN, Q9NYZ2
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 3 Solcar repeats


    Find genes that share domains with SLC25A37           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MFRN1_HUMAN, Q9NYZ2
    Function: Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells,
    thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as
    Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to
    make heme (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005381iron ion transmembrane transporter activity IEA--
         
    Find genes that share ontologies with SLC25A37           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC25A37:
     Synthetic lethal with c-Myc af 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc25a37):
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging 

    Find genes that share phenotypes with SLC25A37           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Slc25a37tm1.2Kapl for SLC25A37

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC25A37
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    miRNA
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    miRTarBase miRNAs that target SLC25A37:
    hsa-mir-7-5p (MIRT025959), hsa-mir-17-5p (MIRT050876)

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    Selected qRT-PCR Assays for microRNAs that regulate SLC25A37 (see all 12):
    hsa-miR-548am hsa-miR-181c hsa-miR-181a hsa-miR-138-2* hsa-miR-181d hsa-miR-1297 hsa-miR-548x hsa-miR-26a
    SwitchGear 3'UTR luciferase reporter plasmidSLC25A37 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A37


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MFRN1_HUMAN, Q9NYZ2: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    nucleus2
    peroxisome2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005743mitochondrial inner membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLC25A37           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC25A37 About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    2Mitochondrial Iron-Sulfur Cluster Biogenesis
    Mitochondrial Iron-Sulfur Cluster Biogenesis


    Find genes that share SuperPaths with SLC25A37           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC25A37
        Mitochondrial iron-sulfur cluster biogenesis


        Pathway & Disease-focused RT2 Profiler PCR Array including SLC25A37: 
              Mitochondria in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SLC25A37

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for SLC25A37 (Q9NYZ23 ENSP000002900754) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABCB7O750273, ENSP000002535774I2D: score=1 STRING: ENSP00000253577
    ENSG00000258947Q135093I2D: score=1 
    SLC25A36Q96CQ13, ENSP000003915214I2D: score=1 STRING: ENSP00000391521
    TUBB3Q135093I2D: score=1 
    CSO753903, ENSP000003420564I2D: score=1 STRING: ENSP00000342056
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0034755iron ion transmembrane transport ----
    GO:0044281small molecule metabolic process TAS--
    GO:0048250mitochondrial iron ion transport IEA--
    GO:0055072iron ion homeostasis IEA--

    Find genes that share ontologies with SLC25A37           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC25A37 (MFRN1)

    2 HMDB Compounds for SLC25A37    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    IronArmco iron (see all 19)7439-89-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC25A37 gene: 
    NM_016612.2  

    Unigene Clusters for SLC25A37:

    Solute carrier family 25 (mitochondrial iron transporter), member 37
    Hs.596025  [show with all ESTs], Hs.658208  [show with all ESTs]
    Unigene Representative Sequences: AF495725, AF116640
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000519973(uc003xdo.3) ENST00000417331 ENST00000290075 ENST00000518881(uc003xdn.1 uc003xdp.3 uc003xdq.3)
    ENST00000519192 ENST00000520654 ENST00000523930 ENST00000523883 ENST00000517923
    ENST00000520949 ENST00000522164 ENST00000521637
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SLC25A37 (see all 12):
    hsa-miR-548am hsa-miR-181c hsa-miR-181a hsa-miR-138-2* hsa-miR-181d hsa-miR-1297 hsa-miR-548x hsa-miR-26a
    SwitchGear 3'UTR luciferase reporter plasmidSLC25A37 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat SLC25A37

    Additional mRNA sequence: 

    AF116640.1 BC033834.1 BC069168.1 

    3 DOTS entries:

    DT.452970  DT.100819463  DT.101961081 

    Selected AceView cDNA sequences (see all 568):

    AW614430 AI243810 AI765135 AI065060 AI261492 N39344 BE221818 BM792434 
    AI589902 CR592142 CB048958 AI307165 AI300376 CK824923 BU677007 BF732747 
    BM552610 AA832397 AA935615 AI766713 CA417633 AA827913 AI220833 CB108744 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A37 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e
    SP1:                                                                                      -     -     -     -     -                                       
    SP2:                          -     -     -     -     -     -     -     -                 -     -     -     -     -                                       
    SP3:                          -           -     -     -     -     -     -                 -     -     -     -     -                                       
    SP4:                          -     -     -     -     -     -                             -     -     -     -     -                                       
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for SLC25A37

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC25A37 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACATCCCCT
    SLC25A37 Expression
    About this image


    SLC25A37 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Erythroblasts Hematopoietic Bone Marrow
     
     Liver (Hepatobiliary System)
    SLC25A37 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC25A37 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.596025 Hs.658208
        Pathway & Disease-focused RT2 Profiler PCR Array including SLC25A37: 
              Mitochondria in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A37

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC25A37 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc25a371 , 5 solute carrier family 25, member 371, 5 88.36(n)1
    91.42(a)1
      14 (36.03 cM)5
    677121  NM_026331.31  NP_080607.21 
     692418485 
    chicken
    (Gallus gallus)
    Aves SLC25A371 solute carrier family 25, member 37 74.61(n)
    78.15(a)
      419530  XM_417682.3  XP_417682.2 
    lizard
    (Anolis carolinensis)
    Reptilia SLC25A376
    solute carrier family 25 (mitochondrial iron trans...
    72(a)
    1 ↔ 1
    GL343754.1(118798-138360)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc25a371 solute carrier family 25 (mitochondrial iron transporter), more 73.27(n)
    74.83(a)
      100379786  XM_002932551.2  XP_002932597.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc25a371 solute carrier family 25, member 37 71.68(n)
    74.58(a)
      387000  NM_001039971.1  NP_001035060.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mfrn1 mitoferrin 60.45(n)
    56.27(a)
      43353  NM_143343.3  NP_651600.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mfn-11 mfn-1 54.12(n)
    55.25(a)
      174752  NM_064046.4  NP_496447.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MRS41 MRS4 47.2(n)
    42.31(a)
      853926   NP_012978.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G301601 AT2G30160 45.95(n)
    42.14(a)
      817568  NM_128571.2  NP_180577.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g02968001 Os03g0296800 50.91(n)
    43.2(a)
      4332542  NM_001056368.1  NP_001049833.1 


    ENSEMBL Gene Tree for SLC25A37 (if available)
    TreeFam Gene Tree for SLC25A37 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC25A37 gene
    SLC25A282  
    2 SIMAP similar genes for SLC25A37 using alignment to 3 protein entries:     MFRN1_HUMAN (see all proteins):
    SLC25A28    SLC25A36

    Find genes that share paralogs with SLC25A37           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC25A37 (see all 1247)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1886975931,2
    --23384426(+) ATAAAA/CTGTAT 1 -- us2k10--------
    rs1932769161,2
    --23384484(+) AAAAAA/GTACAT 1 -- us2k10--------
    rs1998270141,2
    C--23384502(+) TACAC-/ATATATC 1 -- us2k10--------
    rs48721411,2
    C,F,A,H--23384559(+) tatgtG/Atatat 1 -- us2k15Minor allele frequency- A:0.36NA CSA WA 243
    rs48721421,2
    C,A,H--23384611(+) atattC/Gtatac 1 -- us2k13Minor allele frequency- G:0.11NA WA 240
    rs1134037871,2
    C,F--23384620(+) ACATAC/TATACT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs69821441,2
    C--23384791(+) CCATGC/TGATTC 1 -- us2k15Minor allele frequency- T:0.19CSA WA NA EA 360
    rs1436031351,2
    --23385047(+) TCCTGC/TGTATT 1 -- us2k10--------
    rs1850475521,2
    --23385049(+) CTGTGC/TATTTG 1 -- us2k10--------
    rs764184081,2
    C,F--23385167(+) AAAAAC/TGACCT 1 -- us2k11Minor allele frequency- T:0.07EA 120

    HapMap Linkage Disequilibrium report for SLC25A37 (23386318 - 23432976 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLC25A37 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736758CNV Deletion23290073
    esv1990641CNV Deletion18987734
    esv2421786CNV Deletion20811451
    esv4817CNV Deletion18987735
    esv2528186CNV Deletion19546169
    esv22651CNV Loss19812545
    nsv508499CNV Loss20534489
    esv9692CNV Loss19470904
    nsv396338CNV Loss16902084
    nsv471717CNV Loss16327809

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC25A37
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC25A37

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610387    OMIM disorders: --

    1 disease for SLC25A37:    
    About MalaCards
    erythropoietic protoporphyria

    1 disease from the University of Copenhagen DISEASES database for SLC25A37:
    Intrahepatic cholestasis

    Find genes that share disorders with SLC25A37           About GenesLikeMe

    Genetic Association Database (GAD): SLC25A37
    Human Genome Epidemiology (HuGE) Navigator: SLC25A37 (2 documents)

    Export disorders for SLC25A37 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC25A37 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with SLC25A37)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    2. Mitoferrin is essential for erythroid iron assimilation. (PubMed id 16511496)1, 3 Shaw G.C....Paw B.H. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Rapid decrease of RNA level of a novel mouse mitochondria solute carrier protein (Mscp) gene at 4-5 weeks of age. (PubMed id 11845285)1, 2 Li Q.-Z.... She J.-X. (Mamm. Genome 2001)
    5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    6. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PubMed id 23266187)1 Palmieri F. (Mol. Aspects Med. 2013)
    7. Abnormal mitoferrin-1 expression in patients with erythropoietic protoporphyria. (PubMed id 21627978)1 Wang Y....Bloomer J.R. (Exp. Hematol. 2011)
    8. Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. (PubMed id 20676098)4 Takata R....Nakagawa H. (Nat. Genet. 2010)
    9. Hypoxia induces erythroid-specific 5-aminolevulinate synthase expression in human erythroid cells through transforming growth factor-beta signaling. (PubMed id 19187226)1 Kaneko K....Shibahara S. (FEBS J. 2009)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51312 HGNC: 29786 AceView: MSCP Ensembl:ENSG00000147454 euGenes: HUgn51312
    ECgene: SLC25A37 H-InvDB: SLC25A37

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC25A37 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SLC25A37 gene:
    Search GeneIP for patents involving SLC25A37

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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