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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC25A37 Gene

protein-coding   GIFtS: 56
GCID: GC08P023386

Solute Carrier Family 25 (Mitochondrial Iron Transporter),...

(Previous names: solute carrier family 25, member 37)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 25 (Mitochondrial Iron Transporter), Member
371 2
     MSC2
Solute Carrier Family 25, Member 371 2     PRO12782
mitoferrin1 2     PRO15842
Mitochondrial Iron Transporter 12 3     PRO22172
Mitochondrial Solute Carrier Protein2 3     mitoferrin-12
MFRN2 3     Predicted Protein Of HQ22172
MSCP2 3     Solute Carrier Family 25 Member 373
MFRN12     

External Ids:    HGNC: 297861   Entrez Gene: 513122   Ensembl: ENSG000001474547   OMIM: 6103875   UniProtKB: Q9NYZ23   

Export aliases for SLC25A37 gene to outside databases

Previous GC identifers: GC08P023443 GC08P023444 GC08P021931


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC25A37 Gene:
SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron
importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009 (PubMed
19805291)).(supplied by OMIM, Jan 2011)

GeneCards Summary for SLC25A37 Gene: 
SLC25A37 (solute carrier family 25 (mitochondrial iron transporter), member 37) is a protein-coding gene. Diseases associated with SLC25A37 include citrullinemia, and hypochromic anemia, and among its related super-pathways are Metabolic pathways and Electron Transport from NADPH to Ferredoxin. GO annotations related to this gene include iron ion transmembrane transporter activity. An important paralog of this gene is SLC25A28.

UniProtKB/Swiss-Prot: MFRN1_HUMAN, Q9NYZ2
Function: Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells,
thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as
Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to
make heme (By similarity)

Gene Wiki entry for SLC25A37 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_167187.1  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC25A37 gene promoter:
         Max1   AML1a   MyoD   Meis-1b   SEF-1 (1)   ARP-1   Meis-1a   Pax-4a   Meis-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC25A37 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC25A37

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC25A37


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.2   Ensembl cytogenetic band:  8p21.2   HGNC cytogenetic band: 8p21.2

SLC25A37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A37 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P023386:  view genomic region     (about GC identifiers)

Start:
23,386,318 bp from pter      End:
23,432,976 bp from pter
Size:
46,659 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MFRN1_HUMAN, Q9NYZ2 (See protein sequence)
Recommended Name: Mitoferrin-1  
Size: 338 amino acids; 37323 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
Sequence caution: Sequence=AAF64141.1; Type=Frameshift; Positions=296; Sequence=CAH10415.1; Type=Erroneous
translation; Note=Wrong choice of CDS;
Secondary accessions: A2RU93 Q53FT7 Q69YJ8 Q969S1 Q9P0J2
Alternative splicing: 3 isoforms:  Q9NYZ2-1   Q9NYZ2-2   Q9NYZ2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC25A37: NX_Q9NYZ2

Explore proteomics data for SLC25A37 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NYZ2

  • SLC25A37 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC25A37 Protein Expression
    REFSEQ proteins: NP_057696.2  
    ENSEMBL proteins: 
     ENSP00000429200   ENSP00000402782   ENSP00000290075   ENSP00000428066  
    Reactome Protein details: Q9NYZ2
    Human Recombinant Protein Products for SLC25A37: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005743mitochondrial inner membrane IEA--
    GO:0016021integral to membrane IEA--

    SLC25A37 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Mitoferrin1 
    Miscellaneous SLC25 mitochondrial transporters

    2 InterPro protein domains:
     IPR023395 Mt_carrier_dom
     IPR018108 Mitochondrial_sb/sol_carrier

    Graphical View of Domain Structure for InterPro Entry Q9NYZ2

    ProtoNet protein and cluster: Q9NYZ2

    UniProtKB/Swiss-Prot: MFRN1_HUMAN, Q9NYZ2
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 3 Solcar repeats


    SLC25A37 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MFRN1_HUMAN, Q9NYZ2
    Function: Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells,
    thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as
    Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to
    make heme (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005381iron ion transmembrane transporter activity IEA--
         
    SLC25A37 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC25A37:
     Synthetic lethal with c-Myc af 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc25a37):
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging 

    SLC25A37 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Slc25a37tm1.2Kapl for SLC25A37

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    SwitchGear 3'UTR luciferase reporter plasmidSLC25A37 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC25A37 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    2Mitochondrial Iron-Sulfur Cluster Biogenesis
    Mitochondrial Iron-Sulfur Cluster Biogenesis0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for SLC25A37
        Mitochondrial Iron-Sulfur Cluster Biogenesis
    Metabolism



    SLC25A37 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC25A37

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/38 Interacting proteins for SLC25A37 (Q9NYZ23 ENSP000002900754) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABCB7O750273, ENSP000002535774I2D: score=1 STRING: ENSP00000253577
    ENSG00000258947Q135093I2D: score=1 
    TUBB3Q135093I2D: score=1 
    CDK1P064933I2D: score=5 
    EEF1B2P245343I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0034755iron ion transmembrane transport ----
    GO:0044281small molecule metabolic process TAS--
    GO:0048250mitochondrial iron ion transport IEA--
    GO:0055072iron ion homeostasis IEA--

    SLC25A37 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC25A37 (MFRN1)

    2 HMDB Compounds for SLC25A37    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    IronArmco iron (see all 19)7439-89-6--

    Search CenterWatch for drugs/clinical trials and news about SLC25A37 / MFRN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC25A37 gene: 
    NM_016612.2  

    Unigene Clusters for SLC25A37:

    Solute carrier family 25 (mitochondrial iron transporter), member 37
    Hs.596025  [show with all ESTs], Hs.658208  [show with all ESTs], Hs.726050  [show with all ESTs]
    Unigene Representative Sequences: AF495725, AF116640, AK127666
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000519973(uc003xdo.3) ENST00000417331 ENST00000290075 ENST00000518881(uc003xdn.1 uc003xdp.3 uc003xdq.3)
    ENST00000519192 ENST00000520654 ENST00000523930 ENST00000523883 ENST00000517923
    ENST00000520949 ENST00000522164 ENST00000521637
    miRNA
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    hsa-miR-548am hsa-miR-181c hsa-miR-181a hsa-miR-138-2* hsa-miR-181d hsa-miR-1297 hsa-miR-548x hsa-miR-26a
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    Additional mRNA sequence: 

    AF113696.1 AF116630.1 AF155660.1 AF223466.1 AK074708.1 AK075313.1 AK093931.1 AK127666.1 
    AK223194.1 AK314731.1 AL833186.1 AY032628.1 BC015013.2 BC132799.1 BC132801.1 

    23 DOTS entries:

    DT.452970  DT.449372  DT.100766128  DT.121644617  DT.95306265  DT.121473136  DT.95306262  DT.95306263 
    DT.99995790  DT.100819463  DT.101961081  DT.100037610  DT.100037612  DT.121473137  DT.121473189  DT.95306250 
    DT.100765545  DT.100819460  DT.121615475  DT.212879  DT.87017086  DT.91678690  DT.99963359 

    24/568 AceView cDNA sequences (see all 568):

    AI215180 BM792434 BX503388 AI765135 AI167780 CR592142 AF074701 AI307165 
    AI273440 N39344 BQ948619 AF155660 AI133696 BF718357 CB048958 CB053842 
    AI766713 CB163524 CB161066 AI925217 BM968576 AI830053 AA939056 AI203832 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A37 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e
    SP1:                                                                                      -     -     -     -     -                                       
    SP2:                          -     -     -     -     -     -     -     -                 -     -     -     -     -                                       
    SP3:                          -           -     -     -     -     -     -                 -     -     -     -     -                                       
    SP4:                          -     -     -     -     -     -                             -     -     -     -     -                                       
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for SLC25A37

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC25A37 expression in normal human tissues (normalized intensities)      SLC25A37 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACATCCCCT
    SLC25A37 Expression
    About this image


    SLC25A37 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Neural Crest (Gastrulation Derivatives)
             mesenchyme   
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Mesoderm (Gastrulation Derivatives)
             mesenchyme   
     
     Blood (Hematopoietic System)
             Bone Marrow CD105+ Cells   
     
     Liver (Hepatobiliary System)

    See SLC25A37 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC25A37

    SOURCE GeneReport for Unigene clusters: Hs.596025 Hs.658208 Hs.726050
        SABiosciences Expression via Pathway-Focused PCR Array including SLC25A37: 
              Mitochondria in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A37

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC25A37 gene from 9/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc25a371 , 5 solute carrier family 25, member 371, 5 88.36(n)1
    91.42(a)1
      14 (36.03 cM)5
    677121  NM_026331.31  NP_080607.21 
     692418515 
    chicken
    (Gallus gallus)
    Aves SLC25A371 solute carrier family 25, member 37 74.61(n)
    78.15(a)
      419530  XM_417682.2  XP_417682.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC25A376
    Uncharacterized protein
    71(a)
    1 ↔ 1
    GL343754.1(118798-138360)
    zebrafish
    (Danio rerio)
    Actinopterygii slc25a371 solute carrier family 25, member 37 71.92(n)
    74.83(a)
      387000  NM_001039971.1  NP_001035060.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mfrn1 mitoferrin 60.1(n)
    55.91(a)
      43353  NM_143343.2  NP_651600.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mfn-11 Protein MFN-1 54.59(n)
    56.04(a)
      174752  NM_064046.3  NP_496447.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MRS41 Mrs4p 47.2(n)
    41.96(a)
      853926   NP_012978.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G301601 Mitochondrial substrate carrier family protein 46.42(n)
    41.85(a)
      817568  NM_128571.2  NP_180577.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g02968001 hypothetical protein 50.6(n)
    43.48(a)
      4332542  NM_001056368.1  NP_001049833.1 


    ENSEMBL Gene Tree for SLC25A37 (if available)
    TreeFam Gene Tree for SLC25A37 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC25A37 gene
    SLC25A282  
    2 SIMAP similar genes for SLC25A37 using alignment to 3 protein entries:     MFRN1_HUMAN (see all proteins):
    SLC25A28    SLC25A36

    SLC25A37 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1247 SNPs in SLC25A37 are shown (see all 1247)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1886975931,2
    --23384426(+) ATAAAA/CTGTAT 1 -- us2k10--------
    rs1932769161,2
    --23384484(+) AAAAAA/GTACAT 1 -- us2k10--------
    rs1998270141,2
    C--23384502(+) TACAC-/ATATATC 1 -- us2k10--------
    rs48721411,2
    C,F,A,H--23384559(+) tatgtG/Atatat 1 -- us2k15Minor allele frequency- A:0.36NA CSA WA 243
    rs48721421,2
    C,A,H--23384611(+) atattC/Gtatac 1 -- us2k13Minor allele frequency- G:0.11NA WA 240
    rs1134037871,2
    C,F--23384620(+) ACATAC/TATACT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs69821441,2
    C--23384791(+) CCATGC/TGATTC 1 -- us2k15Minor allele frequency- T:0.19CSA WA NA EA 360
    rs1436031351,2
    --23385047(+) TCCTGC/TGTATT 1 -- us2k10--------
    rs1850475521,2
    --23385049(+) CTGTGC/TATTTG 1 -- us2k10--------
    rs764184081,2
    C,F--23385167(+) AAAAAC/TGACCT 1 -- us2k11Minor allele frequency- T:0.07EA 120

    HapMap Linkage Disequilibrium report for SLC25A37 (23386318 - 23432976 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for SLC25A37 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2736758CNV Deletion23290073
    esv1990641CNV Deletion18987734
    esv2421786CNV Deletion20811451
    esv4817CNV Deletion18987735
    esv2528186CNV Deletion19546169
    esv22651CNV Loss19812545
    nsv508499CNV Loss20534489
    esv9692CNV Loss19470904
    nsv396338CNV Loss16902084
    nsv471717CNV Loss16327809

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC25A37
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC25A37

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610387    OMIM disorders: --

    6 diseases for SLC25A37:    About MalaCards
    citrullinemia    hypochromic anemia    intrahepatic cholestasis    cholestasis
    anemia    hypoxia

    1 disease from the University of Copenhagen DISEASES database for SLC25A37:
    Intrahepatic cholestasis

    SLC25A37 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC25A37
    Human Genome Epidemiology (HuGE) Navigator: SLC25A37 (2 documents)

    Export disorders for SLC25A37 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC25A37 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with SLC25A37)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    2. Mitoferrin is essential for erythroid iron assimilation. (PubMed id 16511496)1, 3 Shaw G.C....Paw B.H. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Rapid decrease of RNA level of a novel mouse mitochondria solute carrier protein (Mscp) gene at 4-5 weeks of age. (PubMed id 11845285)1, 2 Li Q.-Z.... She J.-X. (2001)
    5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    6. The mitochondrial transporter family SLC25: identifica tion, properties and physiopathology. (PubMed id 23266187)1 Palmieri F. (2013)
    7. Abnormal mitoferrin-1 expression in patients with ery thropoietic protoporphyria. (PubMed id 21627978)1 Wang Y....Bloomer J.R. (2011)
    8. Genome-wide association study identifies five new sus ceptibility loci for prostate cancer in the Japanese population. (PubMed id 20676098)4 Takata R....Nakagawa H. (2010)
    9. Hypoxia induces erythroid-specific 5-aminolevulinate synthase expression in human erythroid cells through transforming growth factor-beta signaling. (PubMed id 19187226)1 Kaneko K....Shibahara S. (2009)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51312 HGNC: 29786 AceView: MSCP Ensembl:ENSG00000147454 euGenes: HUgn51312
    ECgene: SLC25A37 H-InvDB: SLC25A37

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC25A37 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC25A37 gene:
    Search GeneIP for patents involving SLC25A37

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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