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Aliases for SLC25A36 Gene

Aliases for SLC25A36 Gene

  • Solute Carrier Family 25 Member 36 2 3 5
  • Solute Carrier Family 25 (Pyrimidine Nucleotide Carrier ), Member 36 3
  • Solute Carrier Family 25 (Pyrimidine Nucleotide Carrier), Member 36 2
  • Solute Carrier Family 25, Member 36 2
  • PNC2 3

External Ids for SLC25A36 Gene

Previous GeneCards Identifiers for SLC25A36 Gene

  • GC03P142144
  • GC03P140660
  • GC03P138035

Summaries for SLC25A36 Gene

GeneCards Summary for SLC25A36 Gene

SLC25A36 (Solute Carrier Family 25 Member 36) is a Protein Coding gene. GO annotations related to this gene include pyrimidine nucleotide transmembrane transporter activity. An important paralog of this gene is SLC25A33.

UniProtKB/Swiss-Prot for SLC25A36 Gene

  • Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, Mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A36 Gene

Genomics for SLC25A36 Gene

Regulatory Elements for SLC25A36 Gene

Enhancers for SLC25A36 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G141398 2 FANTOM5 Ensembl ENCODE dbSUPER 1.8 +466.3 466280 18.6 HDGF FOXA2 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 ZBTB38 YWHAQP6 RASA2 SLC25A36 ENSG00000249417 KRT18P35
GH03G140940 1.1 ENCODE 0.7 +1.2 1223 4.1 HDGF PKNOX1 FOXA2 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ENSG00000248773 SLC25A36
GH03G140951 1.2 Ensembl ENCODE 0.4 +11.3 11270 2.6 PKNOX1 ATF1 FEZF1 GATA2 FOS TSHZ1 ZNF488 SMARCB1 ZNF592 MEF2D SLC25A36 ENSG00000248773
GH03G140957 1 ENCODE 0.4 +15.5 15494 0.2 FOXA2 ATF1 MLX ARNT ARID4B FEZF1 DMAP1 YY1 SP5 YY2 ENSG00000248773 SLC25A36
GH03G140954 0.6 ENCODE 0.4 +12.8 12754 0.2 ZNF217 GATA3 PRDM6 GFI1B WT1 PRDM4 EZH2 FOXA1 SLC25A36 ENSG00000248773
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A36 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A36 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000159255 681 2600 HDGF PKNOX1 FOXA2 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1

Genomic Location for SLC25A36 Gene

Chromosome:
3
Start:
140,941,820 bp from pter
End:
140,979,943 bp from pter
Size:
38,124 bases
Orientation:
Plus strand

Genomic View for SLC25A36 Gene

Genes around SLC25A36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A36 Gene

Proteins for SLC25A36 Gene

  • Protein details for SLC25A36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CQ1-S2536_HUMAN
    Recommended name:
    Solute carrier family 25 member 36
    Protein Accession:
    Q96CQ1
    Secondary Accessions:
    • A8MYF7
    • Q05CY1
    • Q9H0G8
    • Q9NVN5

    Protein attributes for SLC25A36 Gene

    Size:
    311 amino acids
    Molecular mass:
    34283 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A36 Gene

Post-translational modifications for SLC25A36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC25A36 Gene

Domains & Families for SLC25A36 Gene

Gene Families for SLC25A36 Gene

Protein Domains for SLC25A36 Gene

Suggested Antigen Peptide Sequences for SLC25A36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96CQ1

UniProtKB/Swiss-Prot:

S2536_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A36: view

Function for SLC25A36 Gene

Molecular function for SLC25A36 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.19 mM for UTP (at 25 degrees Celsius) {ECO:0000269 PubMed:25320081}; KM=0.21 mM for CTP (at 25 degrees Celsius) {ECO:0000269 PubMed:25320081}; KM=2.5 mM for TTP (at 25 degrees Celsius) {ECO:0000269 PubMed:25320081}; KM=0.23 mM for GTP (at 25 degrees Celsius) {ECO:0000269 PubMed:25320081}; Vmax=30.7 umol/min/g enzyme toward UTP (at 25 degrees Celsius) {ECO:0000269 PubMed:25320081}; Vmax=51.2 umol/min/g enzyme toward CTP (at 25 degrees Celsius) {ECO:0000269 PubMed:25320081}; Vmax=8 umol/min/g enzyme toward TTP (at 25 degrees Celsius) {ECO:0000269 PubMed:25320081}; Vmax=23.6 umol/min/g enzyme toward GTP (at 25 degrees Celsius) {ECO:0000269 PubMed:25320081}; Note=The inhibitory constants (Ki) of these compounds are 1.3 um (UTP), 224 um (CTP), 276 um (GTP), and 181 um (ITP). CTP is the best substrate. {ECO:0000269 PubMed:25320081};
UniProtKB/Swiss-Prot Function:
Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, Mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration.

Gene Ontology (GO) - Molecular Function for SLC25A36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015218 pyrimidine nucleotide transmembrane transporter activity IDA 25320081
genes like me logo Genes that share ontologies with SLC25A36: view
genes like me logo Genes that share phenotypes with SLC25A36: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A36

CRISPR Products

miRNA for SLC25A36 Gene

miRTarBase miRNAs that target SLC25A36

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A36 Gene

Localization for SLC25A36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A36 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A36 gene
Compartment Confidence
mitochondrion 5
extracellular 2
peroxisome 2
nucleus 2
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC25A36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA,IEA 25320081
GO:0005743 mitochondrial inner membrane IBA,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with SLC25A36: view

Pathways & Interactions for SLC25A36 Gene

SuperPathways for SLC25A36 Gene

No Data Available

Interacting Proteins for SLC25A36 Gene

Gene Ontology (GO) - Biological Process for SLC25A36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000002 mitochondrial genome maintenance IDA 25320081
GO:0006810 transport IEA --
GO:0006864 pyrimidine nucleotide transport IDA 25320081
GO:0007005 mitochondrion organization IDA 25320081
GO:0051881 regulation of mitochondrial membrane potential IDA 25320081
genes like me logo Genes that share ontologies with SLC25A36: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A36 Gene

Transcripts for SLC25A36 Gene

Unigene Clusters for SLC25A36 Gene

Solute carrier family 25 (pyrimidine nucleotide carrier ), member 36:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A36 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - - - - - -
SP8: - -
SP9: - - -
SP10:
SP11: -

ExUns: 11c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SLC25A36 Gene

GeneLoc Exon Structure for
SLC25A36
ECgene alternative splicing isoforms for
SLC25A36

Expression for SLC25A36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC25A36 Gene

This gene is overexpressed in Frontal cortex (25.5), Retina (17.2), Testis (13.7), and Islet of Langerhans (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC25A36 Gene



Protein tissue co-expression partners for SLC25A36 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC25A36 Gene:

SLC25A36

SOURCE GeneReport for Unigene cluster for SLC25A36 Gene:

Hs.144130

mRNA Expression by UniProt/SwissProt for SLC25A36 Gene:

Q96CQ1-S2536_HUMAN
Tissue specificity: Expressed at moderate level.

Evidence on tissue expression from TISSUES for SLC25A36 Gene

  • Kidney(4.5)
  • Nervous system(4)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with SLC25A36: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A36 Gene

Orthologs for SLC25A36 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A36 34 35
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia SLC25A36 34 35
  • 95.15 (n)
cow
(Bos Taurus)
Mammalia SLC25A36 34 35
  • 93.78 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a36 34
  • 91.85 (n)
mouse
(Mus musculus)
Mammalia Slc25a36 34 16 35
  • 91.21 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC25A36 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A36 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC25A36 34 35
  • 82.64 (n)
lizard
(Anolis carolinensis)
Reptilia SLC25A36 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a36 34
  • 76.66 (n)
Str.11825 34
zebrafish
(Danio rerio)
Actinopterygii slc25a36b 35
  • 79 (a)
OneToMany
slc25a36a 34 35
  • 75.78 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG18317 34 35
  • 55.93 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009333 34
  • 54.66 (n)
worm
(Caenorhabditis elegans)
Secernentea T09F3.2 34 35
  • 55.6 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL253W 34
  • 51.88 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E23629g 34
  • 51.51 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM2 34 35 37
  • 51.11 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC688.09 34
  • 51.52 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01916 34
  • 47.27 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.998 35
  • 42 (a)
OneToMany
Species where no ortholog for SLC25A36 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A36 Gene

ENSEMBL:
Gene Tree for SLC25A36 (if available)
TreeFam:
Gene Tree for SLC25A36 (if available)

Paralogs for SLC25A36 Gene

Paralogs for SLC25A36 Gene

(5) SIMAP similar genes for SLC25A36 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for SLC25A36 Gene

genes like me logo Genes that share paralogs with SLC25A36: view

Variants for SLC25A36 Gene

Sequence variations from dbSNP and Humsavar for SLC25A36 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000019563 -- 140,949,917(+) GTCAT(C/G)CACAT intron-variant
rs1000065758 -- 140,949,647(+) GTGAC(A/G)TTTAA intron-variant
rs1000126689 -- 140,955,536(+) CTTAC(A/C)TACCT intron-variant
rs1000216906 -- 140,974,810(+) GCCAG(A/G)CCTAG intron-variant
rs1000232211 -- 140,955,247(+) TATAT(A/G)TATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A36 Gene

Variant ID Type Subtype PubMed ID
nsv521218 CNV loss 19592680
nsv591865 CNV loss 21841781

Variation tolerance for SLC25A36 Gene

Residual Variation Intolerance Score: 41.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A36 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A36 Gene

Disorders for SLC25A36 Gene

Relevant External Links for SLC25A36

Genetic Association Database (GAD)
SLC25A36
Human Genome Epidemiology (HuGE) Navigator
SLC25A36
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A36

No disorders were found for SLC25A36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A36 Gene

Publications for SLC25A36 Gene

  1. The human SLC25A33 and SLC25A36 genes of solute carrier family 25 encode two mitochondrial pyrimidine nucleotide transporters. (PMID: 25320081) Di Noia M.A. … Palmieri F. (J. Biol. Chem. 2014) 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PMID: 19010793) Baranzini S.E. … Oksenberg J.R. (Hum. Mol. Genet. 2009) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for SLC25A36 Gene

Sources for SLC25A36 Gene

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