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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC25A35 Gene

protein-coding   GIFtS: 45
GCID: GC17M008191

solute carrier family 25, member 35

  Search for SLC25A35
in our new
 Human Malady Compendium 
Biological research products
for SLC25A35
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Solute Carrier Family 25, Member 351 2
FLJ402171
Solute Carrier Family 25 Member 352

External Ids:    HGNC: 319211   Entrez Gene: 3995122   Ensembl: ENSG000001254347   OMIM: 6108185   UniProtKB: Q3KQZ13   

Export aliases for SLC25A35 gene to outside databases

Previous GC identifers: GC17M008133 GC17M008086


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC25A35:
SLC25A35 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 (PubMed
16949250)).(supplied by OMIM, Mar 2008)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC25A35 gene promoter:
         C/EBPbeta   RP58   SREBP-1c   MyoD   SREBP-1b   SREBP-1a   FOXO4   SEF-1 (1)   Chx10   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC25A35 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC25A35

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC25A35


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

SLC25A35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A35 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M008191:  view genomic region     (about GC identifiers)

Start:
8,191,081 bp from pter      End:
8,198,661 bp from pter
Size:
7,581 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S2535_HUMAN, Q3KQZ1 (See protein sequence)
Recommended Name: Solute carrier family 25 member 35  
Size: 300 amino acids; 32438 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: Q494X5 Q6RGS3 Q8N7Y5
Alternative splicing: 4 isoforms:  Q3KQZ1-1   Q3KQZ1-2   Q3KQZ1-3   Q3KQZ1-4   

Explore the universe of human proteins at neXtProt for SLC25A35: NX_Q3KQZ1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q3KQZ1

  • SLC25A35 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins: NP_958928.1  
    ENSEMBL proteins: 
     ENSP00000462395   ENSP00000369407   ENSP00000464191   ENSP00000464071   ENSP00000464307  
     ENSP00000464231   ENSP00000379574  

    Human Recombinant Protein Products for SLC25A35: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC25A35

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IEA--
    GO:0016021integral to membrane IEA--

    SLC25A35 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLC25A35


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SLC25A35 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR023395 Mt_carrier_dom
     IPR018108 Mitochondrial_sb/sol_carrier

    Graphical View of Domain Structure for InterPro Entry Q3KQZ1

    ProtoNet protein and cluster: Q3KQZ1

    UniProtKB/Swiss-Prot: S2535_HUMAN, Q3KQZ1
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 3 Solcar repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         2 GenomeRNAi human phenotypes for SLC25A35:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC25A35 

    miRNA
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    hsa-miR-3934 hsa-miR-588 hsa-miR-663 hsa-miR-548s hsa-miR-1908 hsa-miR-744
    SwitchGear 3'UTR luciferase reporter plasmidSLC25A35 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A35


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC25A35

    5/23 Interacting proteins for SLC25A35 (Q3KQZ13) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TOMM70AO948263I2D: score=4 
    TNPO1Q929733I2D: score=3 
    RANP628263I2D: score=2 
    ATP6V1DQ9Y5K83I2D: score=1 
    BYSLQ138953I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--

    SLC25A35 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC25A35
    Search CenterWatch for drugs/clinical trials and news about SLC25A35 / S2535 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC25A35 gene: 
    NM_201520.1  

    Unigene Cluster for SLC25A35:

    Solute carrier family 25, member 35
    Hs.118918  [show with all ESTs]
    Unigene Representative Sequence: NM_201520
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000579192(uc002gkt.3) ENST00000380067(uc002gku.1) ENST00000581320
    ENST00000585311(uc002gkz.1) ENST00000580340 ENST00000579681 ENST00000577745(uc002gla.4)
    ENST00000396278

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC25A35:
    hsa-miR-3934 hsa-miR-588 hsa-miR-663 hsa-miR-548s hsa-miR-1908 hsa-miR-744
    SwitchGear 3'UTR luciferase reporter plasmidSLC25A35 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC25A35 (see all 7)
    Browse OriGene siRNA
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    Additional cDNA sequence: 

    AK097536.1 AY498866.1 BC041597.1 BC052233.1 BC101329.2 BC101330.2 BC105995.1 

    9 DOTS entries:

    DT.75151041  DT.100798238  DT.95098113  DT.102826454  DT.120927307  DT.100706391  DT.40237620  DT.86852501 
    DT.86853480 

    24/87 AceView cDNA sequences (see all 87):

    AI348535 BQ937143 AW952599 BM698434 AI243970 NM_201520 CB140699 BI824224 
    AI635014 BG674342 AL697641 BC041597 CB145476 BM987725 BC052233 AK097536 
    AI862115 AI344200 BM043986 N63045 BU502168 AY498866 BX107248 BG774984 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A35    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
    SP1:                          -     -               
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for SLC25A35

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC25A35 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGTGCTTCA
    SLC25A35 Expression
    About this image

    SLC25A35 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryPrimary FollicleGranulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    Genevestigator expression for SLC25A35

    SOURCE GeneReport for Unigene cluster: Hs.118918
        SABiosciences Custom PCR Arrays for SLC25A35
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A35

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC25A35 gene from 6/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia SLC25A356
    --
    56(a)
    1 ↔ 1
    GL343466.1(159822-166064)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-268m12.51 si:ch211-268m12.5 63.09(n)
    64.05(a)
      557185  NM_001099447.1  NP_001092917.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG183246
    CG183276
    (see all 3)
    --
    40(a)
    39(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2R(10056361-10057738)
    2R(10054487-10055738)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes OAC11 Oac1p 44.92(n)
    38.2(a)
      853739   NP_012802.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G031156
    Mitochondrial substrate carrier family protein
    21(a)
    possible ortholog
    4(1382438-1385485)
    rice
    (Oryza sativa)
    Liliopsida --
    mitochondrial carrier protein, putative, expressed...
    24(a)
    possible ortholog
    12(21192352-21195968)


    ENSEMBL Gene Tree for SLC25A35 (if available)
    TreeFam Gene Tree for SLC25A35 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC25A35 gene
    SLC25A342  
    6 SIMAP similar genes for SLC25A35 using alignment to 1 protein entry:     S2535_HUMAN:
    SLC25A34    SLC25A11    SLC25A27    SLC25A14    SLC25A30    UCP1

    SLC25A35 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/105 NCBI SNPs in SLC25A35 are shown (see all 105    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1884623141,2
    --8193950(+) CGGTCC/TGAGCT 1 -- int10--------
    rs1389764711,2
    --8193982(+) ATCCCC/TCGGTA 1 -- int10--------
    rs1930410811,2
    --8193983(+) TCCCCC/TGGTAC 1 -- int10--------
    rs1428817431,2
    C--8194133(+) CTTCCC/TGCCTG 1 -- int10--------
    rs1996670581,2
    --8194160(+) CTTACC/TTTGCC 2 K syn10--------
    rs1448017041,2
    F--8194206(+) AGGCCA/GCATCA 2 A V mis11Minor allele frequency- G:0.00NA 4548
    rs1439350611,2
    F--8194249(+) ACTCAT/CCATGG 2 /M /V mis11Minor allele frequency- C:0.00NA 4548
    rs728352721,2
    C,F--8194318(+) AGAGCG/ATTGTC 1 -- int15Minor allele frequency- A:0.43NA WA EA EU 1673
    rs65030981,2
    C,F,A--8194319(+) GAGCGC/TTGTCA 1 -- int19Minor allele frequency- T:0.29NA CSA WA EA EU 1689
    rs80766711,2
    C--8194320(+) AGCGTG/TGTCAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for SLC25A35 (8191081 - 8198661 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLC25A35: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC25A35
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SLC25A35 for disorders           About MalaCards

    SLC25A35 for disorders           About GeneDecksing

    OMIM gene information: 610818    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: SLC25A35 (1 document)

    Export disorders for SLC25A35 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC25A35 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SLC25A35)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PubMed id 16949250)1, 2 Haitina T.... Fredriksson R. (2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 399512 HGNC: 31921 AceView: FLJ40217 Ensembl:ENSG00000125434 euGenes: HUgn399512
    ECgene: SLC25A35 H-InvDB: SLC25A35

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC25A35 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC25A35 gene:
    Search GeneIP for patents involving SLC25A35

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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