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Aliases for SLC25A35 Gene

Aliases for SLC25A35 Gene

  • Solute Carrier Family 25 Member 35 2 3 5
  • Solute Carrier Family 25, Member 35 2

External Ids for SLC25A35 Gene

Previous GeneCards Identifiers for SLC25A35 Gene

  • GC17M008133
  • GC17M008086
  • GC17M008191

Summaries for SLC25A35 Gene

Entrez Gene Summary for SLC25A35 Gene

  • SLC25A35 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC25A35 Gene

SLC25A35 (Solute Carrier Family 25 Member 35) is a Protein Coding gene. An important paralog of this gene is SLC25A34.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A35 Gene

Genomics for SLC25A35 Gene

Regulatory Elements for SLC25A35 Gene

Enhancers for SLC25A35 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F008245 0.4 ENCODE 23.6 +47.5 47470 5.5 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 PFAS SENP3 CNTROB CTC1 NEURL4 SNORD10 CYB5D1 SLC25A35 SNORA48 NLGN2
GH17F007334 0.2 ENCODE 13.7 +958.9 958939 3.5 HDGF PKNOX1 CREB3L1 ARID4B SIN3A YY1 ZNF766 ZNF143 ZNF207 ZNF263 PFAS DVL2 CNTROB CTC1 SNORA48 ACAP1 SNORD10 SLC25A35 ENSG00000262089 ENSG00000226871
GH17F008326 0.7 Ensembl ENCODE 11.2 -31.5 -31502 1.8 RNF2 SAP130 L3MBTL2 UBTF ZNF48 ZBTB7A HBP1 GABPA POLR2A GABPB1 ODF4 KRBA2 SLC25A35 RANGRF PFAS CTC1 AURKB RNF222 SNORD118 TMEM107
GH17F008408 0.6 Ensembl ENCODE 11 -113.2 -113203 1.0 ZNF263 TFAP4 SAP130 NR2F2 TEAD3 GLIS2 ZFHX2 GLIS1 GABPB1 FOXP2 RPL26 KRBA2 SLC25A35 RANGRF PFAS RNU7-43P MYH10 NDEL1 RNF222
GH17F008412 1.4 FANTOM5 Ensembl ENCODE 10.6 -117.6 -117582 1.6 KLF1 ATF1 TBL1XR1 JUN CEBPG HIC1 ZNF664 GLIS2 SCRT2 PRDM10 RPL26 KRBA2 SLC25A35 RANGRF PFAS NDEL1 PIK3R6 CNTROB PER1 BORCS6
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SLC25A35 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001340448 -300 1401 HDGF ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 FOS KLF13

Genomic Location for SLC25A35 Gene

Chromosome:
17
Start:
8,287,763 bp from pter
End:
8,295,400 bp from pter
Size:
7,638 bases
Orientation:
Minus strand

Genomic View for SLC25A35 Gene

Genes around SLC25A35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A35 Gene

Proteins for SLC25A35 Gene

  • Protein details for SLC25A35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KQZ1-S2535_HUMAN
    Recommended name:
    Solute carrier family 25 member 35
    Protein Accession:
    Q3KQZ1
    Secondary Accessions:
    • Q494X5
    • Q6RGS3
    • Q8N7Y5

    Protein attributes for SLC25A35 Gene

    Size:
    300 amino acids
    Molecular mass:
    32438 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A35 Gene

Post-translational modifications for SLC25A35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC25A35 Gene

Domains & Families for SLC25A35 Gene

Gene Families for SLC25A35 Gene

Protein Domains for SLC25A35 Gene

Suggested Antigen Peptide Sequences for SLC25A35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3KQZ1

UniProtKB/Swiss-Prot:

S2535_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A35: view

Function for SLC25A35 Gene

Phenotypes for SLC25A35 Gene

genes like me logo Genes that share phenotypes with SLC25A35: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC25A35 Gene

Localization for SLC25A35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A35 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A35 Gene COMPARTMENTS Subcellular localization image for SLC25A35 gene
Compartment Confidence
mitochondrion 4
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SLC25A35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC25A35: view

Pathways & Interactions for SLC25A35 Gene

SuperPathways for SLC25A35 Gene

No Data Available

Interacting Proteins for SLC25A35 Gene

Gene Ontology (GO) - Biological Process for SLC25A35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with SLC25A35: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A35 Gene

Transcripts for SLC25A35 Gene

Unigene Clusters for SLC25A35 Gene

Solute carrier family 25, member 35:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A35 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
SP1: - -
SP2:
SP3:

Relevant External Links for SLC25A35 Gene

GeneLoc Exon Structure for
SLC25A35
ECgene alternative splicing isoforms for
SLC25A35

Expression for SLC25A35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC25A35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A35 Gene

This gene is overexpressed in Testis (x4.1).

Protein differential expression in normal tissues from HIPED for SLC25A35 Gene

This gene is overexpressed in Placenta (11.5), Bone (11.0), Peripheral blood mononuclear cells (10.1), and Adipocyte (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC25A35 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC25A35 Gene:

SLC25A35

SOURCE GeneReport for Unigene cluster for SLC25A35 Gene:

Hs.118918
genes like me logo Genes that share expression patterns with SLC25A35: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SLC25A35 Gene

Orthologs for SLC25A35 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A35 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A35 34 35
  • 91.5 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a35 34
  • 89.99 (n)
cow
(Bos Taurus)
Mammalia SLC25A35 34 35
  • 89.76 (n)
mouse
(Mus musculus)
Mammalia Slc25a35 34 16 35
  • 88.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A35 35
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC25A35 35
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC25A35 35
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc25a35 34 35
  • 63.09 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005239 34
  • 53.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG18324 35
  • 40 (a)
ManyToMany
CG18327 35
  • 38 (a)
ManyToMany
CG8323 35
  • 38 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL023W 34
  • 51.93 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OAC1 35
  • 29 (a)
OneToMany
Species where no ortholog for SLC25A35 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC25A35 Gene

ENSEMBL:
Gene Tree for SLC25A35 (if available)
TreeFam:
Gene Tree for SLC25A35 (if available)

Paralogs for SLC25A35 Gene

Paralogs for SLC25A35 Gene

(6) SIMAP similar genes for SLC25A35 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC25A35: view

Variants for SLC25A35 Gene

Sequence variations from dbSNP and Humsavar for SLC25A35 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs140704891 Likely benign 8,289,059(+) GGGGC(G/T)AAGCG intron-variant, nc-transcript-variant, downstream-variant-500B, reference, utr-variant-3-prime, stop-gained
rs150856064 Likely benign 8,288,840(+) CCATC(A/C/T)TCCCC intron-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs151189313 Uncertain significance 8,289,515(+) AGGAC(A/G/T)TGACA intron-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs751751942 Uncertain significance 8,289,312(+) GTGGA(C/G)TCTGT intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs786205827 Uncertain significance 8,289,029(+) TGGAA(C/G)TTCTC intron-variant, nc-transcript-variant, reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC25A35 Gene

Variant ID Type Subtype PubMed ID
esv3554096 CNV deletion 23714750
nsv833353 CNV loss 17160897

Variation tolerance for SLC25A35 Gene

Residual Variation Intolerance Score: 48.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A35 Gene

Disorders for SLC25A35 Gene

Relevant External Links for SLC25A35

Genetic Association Database (GAD)
SLC25A35
Human Genome Epidemiology (HuGE) Navigator
SLC25A35
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A35

No disorders were found for SLC25A35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A35 Gene

Publications for SLC25A35 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T. … Fredriksson R. (Genomics 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F. (Mol. Aspects Med. 2013) 3 64

Products for SLC25A35 Gene

Sources for SLC25A35 Gene

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