SLC25A35 Gene
protein-coding GIFtS : 45
GCID: GC17 M008191
solute carrier family 25, member 35
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Aliasesfor SLC25A35 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Solute Carrier Family 25, Member 35 1 2 FLJ402171 Solute Carrier Family 25 Member 352
Export aliases for SLC25A35 gene to outside databases Previous GC identifers: GC17M008133 GC17M008086
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Summariesfor SLC25A35 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for SLC25A35 : SLC25A35 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 (PubMed 16949250)).(supplied by OMIM, Mar 2008)
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Genomic Viewsfor SLC25A35 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000017.10 NC_018928.1 NT_010718.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SLC25A35 gene promoter: C/EBPbeta RP58 SREBP-1c MyoD SREBP-1b SREBP-1a FOXO4 SEF-1 (1) Chx10 Pax-4a Other transcription factors Search SABiosciences Chromatin IP Primers for SLC25A35 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SLC25A35
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1 SLC25A35 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17M008191: view genomic region
(about GC identifiers )
Start:
8,191,081 bp from pter
End:
8,198,661 bp from pter
Size:
7,581 bases
Orientation:
minus strand
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Proteinsfor SLC25A35 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: S2535_HUMAN, Q3KQZ1 (See
protein sequence )Recommended Name: Solute carrier family 25 member 35 Size : 300 amino acids; 32438 Da
Subcellular location : Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
Secondary accessions : Q494X5 Q6RGS3 Q8N7Y5Alternative splicing : 4 isoforms : Q3KQZ1-1 Q3KQZ1-2 Q3KQZ1-3 Q3KQZ1-4 Explore the universe of human proteins at neXtProt for SLC25A35: NX_Q3KQZ1 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q3KQZ1 SLC25A35 Protein expression data from MOPED and PaxDb : --REFSEQ proteins: NP_958928.1 ENSEMBL proteins: ENSP00000462395 ENSP00000369407 ENSP00000464191 ENSP00000464071 ENSP00000464307 ENSP00000464231 ENSP00000379574 Human Recombinant Protein Products for SLC25A35: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
SLC25A35 for ontologies About GeneDecksing SLC25A35 Antibody Products: Assay Products for SLC25A35:
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Protein
Domains / Familiesfor SLC25A35 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SLC25A35 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q3KQZ1 ProtoNet protein and cluster: Q3KQZ1
UniProtKB/Swiss-Prot: S2535_HUMAN, Q3KQZ1 Similarity : Belongs to the mitochondrial carrier (TC 2.A.29) familySimilarity : Contains 3 Solcar repeats
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Functionfor SLC25A35 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Phenotypes: 2 GenomeRNAi human phenotypes for SLC25A35 :Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SLC25A35 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SLC25A35OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SLC25A35 (NM_201520 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC25A35 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SLC25A35
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A35
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Pathways & Interactionsfor SLC25A35 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC25A35 5/23 Interacting proteins for SLC25A35 (Q3KQZ1 3 ) via UniProtKB, MINT, STRING, and/or I2D (see all 23 )About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006810 transport
IEA --
SLC25A35 for ontologies About GeneDecksing
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Drugs & Compoundsfor SLC25A35 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SLC25A35 Search CenterWatch for drugs/clinical trials and news about SLC25A35 / S2535
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Transcriptsfor SLC25A35 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SLC25A35 gene: NM_201520.1 Unigene Cluster for SLC25A35:
Solute carrier family 25, member 35 Hs.118918 [show with all ESTs ] Unigene Representative Sequence: NM_201520 8 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000579192 (uc002gkt.3 ) ENST00000380067 (uc002gku.1 ) ENST00000581320 ENST00000585311 (uc002gkz.1 ) ENST00000580340 ENST00000579681 ENST00000577745 (uc002gla.4 )ENST00000396278 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SLC25A35 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SLC25A35OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SLC25A35 (NM_201520 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC25A35 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SLC25A35
Additional cDNA sequence: AK097536.1 AY498866.1 BC041597.1 BC052233.1 BC101329.2 BC101330.2 BC105995.1
9 DOTS entries : DT.75151041 DT.100798238
DT.95098113 DT.102826454 DT.120927307 DT.100706391 DT.40237620 DT.86852501 DT.86853480 24/87 AceView cDNA sequences (see all 87 ):
AI348535 BQ937143 AW952599 BM698434 AI243970 NM_201520 CB140699 BI824224 AI635014 BG674342 AL697641 BC041597 CB145476 BM987725 BC052233 AK097536 AI862115 AI344200 BM043986 N63045 BU502168 AY498866 BX107248 BG774984 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A35 About this scheme ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 SP1 :         -   -       SP2 :                 SP3 :                
ECgene alternative splicing isoforms for SLC25A35
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Expression for SLC25A35 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SLC25A35 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CAGTGCTTCAAbout this image SLC25A35 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Ovary Primary Follicle Granulosa Cells Ovary Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
Genevestigator expression for SLC25A35 SOURCE GeneReport for Unigene cluster: Hs.118918 SABiosciences Custom PCR Arrays for SLC25A35 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SLC25A35Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SLC25A35 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SLC25A35 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SLC25A35 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A35
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Orthologsfor SLC25A35 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC25A35 gene from 6/25 species (see all 25 ) About this table
ENSEMBL Gene Tree for SLC25A35 (if available)TreeFam Gene Tree for SLC25A35 (if available)
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Paralogsfor SLC25A35 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SLC25A35 gene SLC25A34 2 6 SIMAP similar genes for SLC25A35 using alignment to 1 protein entry: S2535_HUMAN :SLC25A34 SLC25A11 SLC25A27 SLC25A14 SLC25A30 UCP1
SLC25A35 for paralogs About GeneDecksing
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Genomic Variantsfor SLC25A35 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 17 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SLC25A35 (8191081 - 8198661 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for SLC25A35: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SLC25A35
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Disorders
/ Diseasesfor SLC25A35 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
SLC25A35 for disorders About MalaCards
SLC25A35 for disorders About GeneDecksing
OMIM gene information: 610818
OMIM disorders : --Human Genome Epidemiology (HuGE) Navigator: SLC25A35 (1 document)Export disorders for SLC25A35 gene to outside databases
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Publicationsfor SLC25A35 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SLC25A35 gene integrated from 9 sources : (articles sorted by number of sources associating them with SLC25A35) Utopia : connect your pdf to the dynamic world of online information
Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PubMed id 16949250) 1 , 2 Haitina T.... Fredriksson R. (2006) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624) 1 Hendrickson S.L....O'Brien S.J. (2010) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000)
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External Searches for SLC25A35 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SLC25A35 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SLC25A35 gene
(According to HUGE )
About This Section --
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Specialized Databases showing SLC25A35 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for SLC25A35 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for SLC25A35 gene: Search GeneIP for patents involving SLC25A35 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SLC25A35 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies Browse OriGene shRNA RFPs OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SLC25A35 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SLC25A35 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits Browse OriGene siRNAs OriGene 3'-UTR Clone for SLC25A35 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SLC25A35 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SLC25A35 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SLC25A35 OriGene Custom Protein Services for SLC25A35 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC25A35 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SLC25A35 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SLC25A35 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SLC25A35 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SLC25A35 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SLC25A35
SLC25A35 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A35
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SLC25A35
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Aliases for SLC25A35
Databases for SLC25A35
Disorders / Diseases for SLC25A35
Domains / Families for SLC25A35
Drugs / Compounds for SLC25A35
Expression for SLC25A35
Function for SLC25A35
Genomic Views for SLC25A35
Intellectual Property for SLC25A35
Orthologs for SLC25A35
Paralogs for SLC25A35
Pathways / Interactions for SLC25A35
Products for SLC25A35
Proteins for SLC25A35
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Transcripts for SLC25A35
Variants for SLC25A35
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