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Aliases for SLC25A35 Gene

Aliases for SLC25A35 Gene

  • Solute Carrier Family 25 Member 35 2 3 5
  • Solute Carrier Family 25, Member 35 2

External Ids for SLC25A35 Gene

Previous GeneCards Identifiers for SLC25A35 Gene

  • GC17M008133
  • GC17M008086
  • GC17M008191

Summaries for SLC25A35 Gene

Entrez Gene Summary for SLC25A35 Gene

  • SLC25A35 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC25A35 Gene

SLC25A35 (Solute Carrier Family 25 Member 35) is a Protein Coding gene. An important paralog of this gene is SLC25A34.

Additional gene information for SLC25A35 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A35 Gene

Genomics for SLC25A35 Gene

GeneHancer (GH) Regulatory Elements for SLC25A35 Gene

Promoters and enhancers for SLC25A35 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I008294 Promoter/Enhancer 1.5 Ensembl ENCODE 556.3 0.0 -13 2.4 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B SLC25A35 ENSG00000271029 CTC1 PFAS
GH17I007833 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 27.3 +455.7 455671 12.5 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 KDM6B DVL2 PFAS CTC1 WRAP53 CNTROB POLR2A SNORD10 SNORA48 PER1
GH17I007716 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 18.7 +578.2 578195 2.1 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B ZNF213 ZNF302 ZNF143 KLF13 DNAH2 DVL2 SNORD10 CTC1 CNTROB SNORA48 WRAP53 PFAS POLR2A ENSG00000265749
GH17I008245 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.2 +47.5 47469 5.5 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 PFAS CTC1 NEURL4 SENP3 CYB5D1 RANGRF CNTROB WRAP53 ZBTB4 NLGN2
GH17I008149 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.5 +138.1 138081 16 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 PER1 VAMP2 ENSG00000265749 CYB5D1 CTC1 DVL2 PFAS CNTROB SENP3 POLR2A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC25A35 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC25A35 gene promoter:

Genomic Locations for SLC25A35 Gene

Genomic Locations for SLC25A35 Gene
chr17:8,287,763-8,295,400
(GRCh38/hg38)
Size:
7,638 bases
Orientation:
Minus strand
chr17:8,191,081-8,198,661
(GRCh37/hg19)

Genomic View for SLC25A35 Gene

Genes around SLC25A35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A35 Gene

Proteins for SLC25A35 Gene

  • Protein details for SLC25A35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KQZ1-S2535_HUMAN
    Recommended name:
    Solute carrier family 25 member 35
    Protein Accession:
    Q3KQZ1
    Secondary Accessions:
    • Q494X5
    • Q6RGS3
    • Q8N7Y5

    Protein attributes for SLC25A35 Gene

    Size:
    300 amino acids
    Molecular mass:
    32438 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A35 Gene

Post-translational modifications for SLC25A35 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SLC25A35 Gene

Domains & Families for SLC25A35 Gene

Gene Families for SLC25A35 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC25A35 Gene

Suggested Antigen Peptide Sequences for SLC25A35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3KQZ1

UniProtKB/Swiss-Prot:

S2535_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A35: view

Function for SLC25A35 Gene

Phenotypes From GWAS Catalog for SLC25A35 Gene

Gene Ontology (GO) - Molecular Function for SLC25A35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC25A35: view

Phenotypes for SLC25A35 Gene

genes like me logo Genes that share phenotypes with SLC25A35: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC25A35 Gene

Localization for SLC25A35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A35 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A35 gene
Compartment Confidence
mitochondrion 4
plasma membrane 1
extracellular 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC25A35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with SLC25A35: view

Pathways & Interactions for SLC25A35 Gene

SuperPathways for SLC25A35 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC25A35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006839 mitochondrial transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A35: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A35 Gene

Drugs & Compounds for SLC25A35 Gene

No Compound Related Data Available

Transcripts for SLC25A35 Gene

Unigene Clusters for SLC25A35 Gene

Solute carrier family 25, member 35:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A35 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
SP1: - -
SP2:
SP3:

Relevant External Links for SLC25A35 Gene

GeneLoc Exon Structure for
SLC25A35
ECgene alternative splicing isoforms for
SLC25A35

Expression for SLC25A35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A35 Gene

This gene is overexpressed in Testis (x4.1).

Protein differential expression in normal tissues from HIPED for SLC25A35 Gene

This gene is overexpressed in Placenta (11.5), Bone (11.0), Peripheral blood mononuclear cells (10.1), and Adipocyte (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC25A35 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC25A35 Gene:

SLC25A35

SOURCE GeneReport for Unigene cluster for SLC25A35 Gene:

Hs.118918

Evidence on tissue expression from TISSUES for SLC25A35 Gene

  • Skin(4)
genes like me logo Genes that share expression patterns with SLC25A35: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A35 Gene

Orthologs for SLC25A35 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A35 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A35 33 34
  • 91.5 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a35 33
  • 89.99 (n)
cow
(Bos Taurus)
Mammalia SLC25A35 33 34
  • 89.76 (n)
mouse
(Mus musculus)
Mammalia Slc25a35 33 16 34
  • 88.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A35 34
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC25A35 34
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC25A35 34
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc25a35 33 34
  • 63.09 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005239 33
  • 53.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG18324 34
  • 40 (a)
ManyToMany
CG18327 34
  • 38 (a)
ManyToMany
CG8323 34
  • 38 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL023W 33
  • 51.93 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OAC1 34
  • 29 (a)
OneToMany
Species where no ortholog for SLC25A35 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC25A35 Gene

ENSEMBL:
Gene Tree for SLC25A35 (if available)
TreeFam:
Gene Tree for SLC25A35 (if available)

Paralogs for SLC25A35 Gene

Paralogs for SLC25A35 Gene

(6) SIMAP similar genes for SLC25A35 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC25A35: view

Variants for SLC25A35 Gene

Sequence variations from dbSNP and Humsavar for SLC25A35 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs138959557 benign, not specified, Cardiac arrhythmia 8,289,331(-) T/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs140704891 likely-benign, benign, not specified, Cardiac arrhythmia 8,289,059(-) G/A/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs150856064 uncertain-significance, not specified, Cardiac arrhythmia 8,288,840(-) C/A/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs200305092 likely-benign, not specified, Cardiac arrhythmia 8,288,815(-) G/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs201882524 uncertain-significance, Cardiac arrhythmia 8,289,585(-) C/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A35 Gene

Variant ID Type Subtype PubMed ID
esv3554096 CNV deletion 23714750
nsv833353 CNV loss 17160897

Variation tolerance for SLC25A35 Gene

Residual Variation Intolerance Score: 48.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC25A35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A35 Gene

Disorders for SLC25A35 Gene

Additional Disease Information for SLC25A35

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC25A35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A35 Gene

Publications for SLC25A35 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  2. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T … Fredriksson R (Genomics 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for SLC25A35 Gene

Sources for SLC25A35 Gene

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