Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC25A34 Gene

Aliases for SLC25A34 Gene

  • Solute Carrier Family 25 Member 34 2 3 5
  • Solute Carrier Family 25, Member 34 2

External Ids for SLC25A34 Gene

Previous GeneCards Identifiers for SLC25A34 Gene

  • GC01P015809
  • GC01P015935
  • GC01P016062
  • GC01P014581

Summaries for SLC25A34 Gene

Entrez Gene Summary for SLC25A34 Gene

  • SLC25A34 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC25A34 Gene

SLC25A34 (Solute Carrier Family 25 Member 34) is a Protein Coding gene. An important paralog of this gene is SLC25A35.

Additional gene information for SLC25A34 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A34 Gene

Genomics for SLC25A34 Gene

Regulatory Elements for SLC25A34 Gene

Enhancers for SLC25A34 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H015734 1.3 Ensembl ENCODE dbSUPER 35.8 +1.1 1134 3 TFAP4 FOXA2 KLF1 SAP130 ARID4B MAX RAD21 BCL11B HIC1 ZNF121 SLC25A34 AGMAT ENSG00000237938
GH01H015740 1.2 Ensembl ENCODE 21.3 +7.1 7073 2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 KLF7 DEK SP3 SLC25A34 PLEKHM2 TMEM82 ENSG00000237938
GH01H015678 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.7 -52.7 -52731 7 PKNOX1 SIN3A YBX1 GLIS2 ZNF143 FOS ATF7 RUNX3 JUNB MEF2D PLEKHM2 SPEN CROCCP3 CASP9 SLC25A34 LINC01772 CROCCP2 ZBTB17 RPL22P3 AGMAT
GH01H015702 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.8 -31.2 -31201 2 CTCF FOXA2 RAD21 ZNF121 ZFHX2 ZNF316 ZNF366 EGR1 FOS PRDM10 SLC25A34 PLEKHM2 TMEM82 FAM131C PIR54516 PIR59281
GH01H015629 1 ENCODE dbSUPER 21.2 -104.8 -104772 1 NFIB ZNF571 ZNF195 ZNF662 SALL2 ZNF491 ZNF776 NFIC LCORL ZNF544 TMEM51-AS1 SLC25A34 NBPF1 SPEN CROCCP3 RSC1A1 PLEKHM2 RNU7-179P ENSG00000237938 SCARNA21B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A34 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A34 Gene

Chromosome:
1
Start:
15,735,088 bp from pter
End:
15,741,396 bp from pter
Size:
6,309 bases
Orientation:
Plus strand

Genomic View for SLC25A34 Gene

Genes around SLC25A34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A34 Gene

Proteins for SLC25A34 Gene

  • Protein details for SLC25A34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PIV7-S2534_HUMAN
    Recommended name:
    Solute carrier family 25 member 34
    Protein Accession:
    Q6PIV7
    Secondary Accessions:
    • Q68DV0

    Protein attributes for SLC25A34 Gene

    Size:
    304 amino acids
    Molecular mass:
    32224 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC25A34 Gene

Post-translational modifications for SLC25A34 Gene

No Post-translational modifications

Other Protein References for SLC25A34 Gene

No data available for DME Specific Peptides for SLC25A34 Gene

Domains & Families for SLC25A34 Gene

Gene Families for SLC25A34 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC25A34 Gene

Suggested Antigen Peptide Sequences for SLC25A34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PIV7

UniProtKB/Swiss-Prot:

S2534_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A34: view

Function for SLC25A34 Gene

Phenotypes From GWAS Catalog for SLC25A34 Gene

Gene Ontology (GO) - Molecular Function for SLC25A34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC25A34: view
genes like me logo Genes that share phenotypes with SLC25A34: view

Animal Model Products

CRISPR Products

miRNA for SLC25A34 Gene

miRTarBase miRNAs that target SLC25A34

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC25A34
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A34 Gene

Localization for SLC25A34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A34 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A34 gene
Compartment Confidence
mitochondrion 4
plasma membrane 3
extracellular 1
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC25A34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with SLC25A34: view

Pathways & Interactions for SLC25A34 Gene

SuperPathways for SLC25A34 Gene

No Data Available

Interacting Proteins for SLC25A34 Gene

Gene Ontology (GO) - Biological Process for SLC25A34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006839 mitochondrial transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A34: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A34 Gene

Drugs & Compounds for SLC25A34 Gene

No Compound Related Data Available

Transcripts for SLC25A34 Gene

Unigene Clusters for SLC25A34 Gene

Solute carrier family 25, member 34:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC25A34
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A34 Gene

No ASD Table

Relevant External Links for SLC25A34 Gene

GeneLoc Exon Structure for
SLC25A34
ECgene alternative splicing isoforms for
SLC25A34

Expression for SLC25A34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A34 Gene

This gene is overexpressed in Muscle - Skeletal (x7.6).

NURSA nuclear receptor signaling pathways regulating expression of SLC25A34 Gene:

SLC25A34

SOURCE GeneReport for Unigene cluster for SLC25A34 Gene:

Hs.631867

Evidence on tissue expression from TISSUES for SLC25A34 Gene

  • Intestine(4.1)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with SLC25A34: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A34 Gene

Orthologs for SLC25A34 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A34 33 34
  • 99.23 (n)
cow
(Bos Taurus)
Mammalia SLC25A34 33 34
  • 88.71 (n)
dog
(Canis familiaris)
Mammalia SLC25A34 33 34
  • 88.23 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a34 33
  • 86.27 (n)
mouse
(Mus musculus)
Mammalia Slc25a34 33 16 34
  • 86.03 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC25A34 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A34 34
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC25A34 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a34 33
  • 70.12 (n)
zebrafish
(Danio rerio)
Actinopterygii slc25a34 33
  • 66.55 (n)
CABZ01052268.1 34
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8323 33 34
  • 54.77 (n)
CG18324 34
  • 42 (a)
ManyToMany
CG18327 34
  • 42 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12826g 33
  • 48.12 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OAC1 33 34 36
  • 42.96 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07884 33
  • 51.58 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes oac1 33
  • 44.64 (n)
Species where no ortholog for SLC25A34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC25A34 Gene

ENSEMBL:
Gene Tree for SLC25A34 (if available)
TreeFam:
Gene Tree for SLC25A34 (if available)

Paralogs for SLC25A34 Gene

Paralogs for SLC25A34 Gene

(8) SIMAP similar genes for SLC25A34 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC25A34: view

Variants for SLC25A34 Gene

Sequence variations from dbSNP and Humsavar for SLC25A34 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000642160 -- 15,737,768(+) CCAGA(C/G)CTGCA intron-variant
rs1000902757 -- 15,733,138(+) GGGGG(C/T)AGAGG intron-variant, upstream-variant-2KB
rs1000915865 -- 15,740,775(+) ACCTC(C/T)ACCTC upstream-variant-2KB, utr-variant-3-prime
rs1000988714 -- 15,735,957(+) GAGTT(A/G)GCCGT nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001202069 -- 15,735,106(+) CTCCA(C/T)AGCCC intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC25A34 Gene

Variant ID Type Subtype PubMed ID
dgv11n27 CNV gain 19166990
dgv151n54 CNV gain 21841781
esv3585317 CNV gain 21293372
esv3585319 CNV gain 21293372
nsv508925 CNV insertion 20534489
nsv524044 CNV loss 19592680
nsv545617 CNV loss 21841781
nsv954825 CNV deletion 24416366

Variation tolerance for SLC25A34 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A34 Gene

Disorders for SLC25A34 Gene

Relevant External Links for SLC25A34

Genetic Association Database (GAD)
SLC25A34
Human Genome Epidemiology (HuGE) Navigator
SLC25A34
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A34

No disorders were found for SLC25A34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A34 Gene

Publications for SLC25A34 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  2. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T … Fredriksson R (Genomics 2006) 3 4 60
  3. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F (Molecular aspects of medicine 2013) 3 60
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 60
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 60

Products for SLC25A34 Gene

Sources for SLC25A34 Gene

Content
Loading form....