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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC25A34 Gene

protein-coding   GIFtS: 45
GCID: GC01P016062

Solute Carrier Family 25, Member 34

  Search for SLC25A34
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 25, Member 341 2
RP11-169K16.22
Solute Carrier Family 25 Member 342

External Ids:    HGNC: 276531   Entrez Gene: 2847232   Ensembl: ENSG000001624617   OMIM: 6108175   UniProtKB: Q6PIV73   

Export aliases for SLC25A34 gene to outside databases

Previous GC identifers: GC01P015809 GC01P015935 GC01P014581


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC25A34 Gene:
SLC25A34 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 (PubMed
16949250)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SLC25A34 Gene: 
SLC25A34 (solute carrier family 25, member 34) is a protein-coding gene. An important paralog of this gene is SLC25A35.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004610.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC25A34 gene promoter:
         CP2   HOXA5   Nkx2-5   Tal-1beta   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC25A34 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC25A34

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC25A34


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.21   Ensembl cytogenetic band:  1p36.21   HGNC cytogenetic band: 1p36.13

SLC25A34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A34 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P016062:  view genomic region     (about GC identifiers)

Start:
16,062,809 bp from pter      End:
16,067,891 bp from pter
Size:
5,083 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S2534_HUMAN, Q6PIV7 (See protein sequence)
Recommended Name: Solute carrier family 25 member 34  
Size: 304 amino acids; 32224 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: Q68DV0

Explore the universe of human proteins at neXtProt for SLC25A34: NX_Q6PIV7

Explore proteomics data for SLC25A34 at MOPED 

SLC25A34 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

SLC25A34 Protein Expression

REFSEQ proteins: NP_997231.1  
ENSEMBL proteins: 
 ENSP00000294454  

Human Recombinant Protein Products for SLC25A34: 
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Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion ----
GO:0005743mitochondrial inner membrane IEA--
GO:0016021integral to membrane IEA--

SLC25A34 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
SLC: Solute carriers

IUPHAR Guide to PHARMACOLOGY protein family classification: SLC25A34 
Miscellaneous SLC25 mitochondrial transporters

2 InterPro protein domains:
 IPR023395 Mt_carrier_dom
 IPR018108 Mitochondrial_sb/sol_carrier

Graphical View of Domain Structure for InterPro Entry Q6PIV7

ProtoNet protein and cluster: Q6PIV7

UniProtKB/Swiss-Prot: S2534_HUMAN, Q6PIV7
Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
Similarity: Contains 3 Solcar repeats


SLC25A34 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC25A34 
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC25A34 
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miRNA
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SwitchGear 3'UTR luciferase reporter plasmidSLC25A34 3' UTR sequence
Inhib. RNA
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A34


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC25A34

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for SLC25A34 (Q6PIV73 ENSP000002944544) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ABCA1O954773, ENSP000003638684I2D: score=1 STRING: ENSP00000363868
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006810transport IEA--

SLC25A34 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC25A34 (S2534)

Search CenterWatch for drugs/clinical trials and news about SLC25A34 / S2534

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC25A34 gene: 
NM_207348.1  

Unigene Cluster for SLC25A34:

Solute carrier family 25, member 34
Hs.631867  [show with all ESTs]
Unigene Representative Sequence: BC027998
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000294454(uc001axb.1) ENST00000489568 ENST00000465495
miRNA
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hsa-miR-30c hsa-miR-644 hsa-miR-185* hsa-miR-330-5p hsa-miR-30d hsa-miR-4314 hsa-miR-30a hsa-miR-326
SwitchGear 3'UTR luciferase reporter plasmidSLC25A34 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for SLC25A34
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC25A34
Clone
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OriGene ORF clones in mouse, rat for SLC25A34
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC25A34
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A34
Sirion Biotech Customized lentivirus for stable overexpression of SLC25A34 
                     Customized lentivirus expression plasmids for stable overexpression of SLC25A34 
Primer
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC25A34
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC25A34

Additional mRNA sequence: 

AK024244.1 AL832282.1 BC027998.1 CR749264.1 

3 DOTS entries:

DT.99984953  DT.95140595  DT.95315602 

24/370 AceView cDNA sequences (see all 370):

AW104785 BM721984 AA336278 BI160509 CD674681 AI969245 BC042103 BQ013458 
BG766097 BU845079 BM792826 BQ005553 CD519212 AA676757 BU542284 BQ225218 
BC040441 BM460392 BI862216 BQ011689 BU730339 CF454577 CA406647 BM998777 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC25A34 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
SLC25A34 Expression
About this image


See SLC25A34 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC25A34

SOURCE GeneReport for Unigene cluster: Hs.631867
    SABiosciences Custom PCR Arrays for SLC25A34
Primer
Products:
OriGene qPCR primer pairs and template standards for SLC25A34
OriGene qSTAR qPCR primer pairs in human, mouse for SLC25A34
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC25A34
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC25A34
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A34

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A34 gene from 6/13 species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Slc25a341 , 5 solute carrier family 25, member 341, 5 86.03(n)1
88.78(a)1
  4 (74.64 cM)5
3840711  NM_001013780.11  NP_001013802.11 
 1416188245 
chicken
(Gallus gallus)
Aves LOC1008581921 solute carrier family 25 member 34-like 74.16(n)
65.09(a)
  100858192  XM_003642527.1  XP_003642575.1 
lizard
(Anolis carolinensis)
Reptilia SLC25A346
Uncharacterized protein
71(a)
1 ↔ 1
GL343609.1(195190-202785)
zebrafish
(Danio rerio)
Actinopterygii zgc:658571 zgc:65857 66.55(n)
61.86(a)
  393552  NM_200580.1  NP_956874.1 
fruit fly
(Drosophila melanogaster)
Insecta CG83231 CG8323 55.48(n)
47(a)
  36566  NM_137089.3  NP_610933.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OAC1(YKL120W)4 Mitochondrial inner membrane transporter, transports more   --   11(217344-218318) 853739  NP_012802.1 


ENSEMBL Gene Tree for SLC25A34 (if available)
TreeFam Gene Tree for SLC25A34 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for SLC25A34 gene
SLC25A352  
8 SIMAP similar genes for SLC25A34 using alignment to 1 protein entry:     S2534_HUMAN:
SLC25A35    SLC25A11    UCP2    UCP1    SLC25A30    UCP3
SLC25A27    SLC25A10

SLC25A34 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/170 SNPs in SLC25A34 are shown (see all 170)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs354499271,2
C,F,H--16061804(+) CAACTT/CGGGTG 1 -- us2k124Minor allele frequency- C:0.40NS EA NA WA CSA 2353
rs1823959001,2
--16061895(+) GGTGGG/TCATGT 1 -- us2k10--------
rs609272551,2
C,F--16061942(+) GCTGGC/TCCAGG 1 -- us2k11Minor allele frequency- T:0.22EA 120
rs1421905821,2
--16061953(+) TGGCGC/TTCTCT 1 -- us2k10--------
rs1460818991,2
C--16061962(+) CTTCTC/TAGCGG 1 -- us2k10--------
rs353527841,2
C,F,H--16061966(+) TCAGCG/AGGCAC 1 -- us2k120Minor allele frequency- A:0.16NS EA NA WA 2332
rs1482746461,2
C--16062099(+) AGTGGA/GGGTGG 1 -- us2k10--------
rs802412461,2
C,F--16062134(+) TTTATC/TGGGTG 1 -- us2k11Minor allele frequency- T:0.03WA 118
rs1400418531,2
C--16062325(+) CCCTTC/TTCTAC 1 -- us2k10--------
rs1160414651,2
F--16062361(+) ATAGAC/TGGTGG 1 -- us2k11Minor allele frequency- T:0.03WA 118

HapMap Linkage Disequilibrium report for SLC25A34 (16062809 - 16067891 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for SLC25A34:    About this table     
Variant IDTypeSubtypePubMed ID
nsv508925CNV Insertion20534489
nsv524044CNV Loss19592680
nsv871550CNV Loss21882294
nsv870503CNV Loss21882294
dgv173n71CNV Loss21882294
dgv11n27CNV Gain19166990
dgv172n71CNV Gain21882294
dgv171n71CNV Gain21882294
nsv871462CNV Gain+Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC25A34 for disorders           About MalaCards
OMIM gene information: 610817    OMIM disorders: --


SLC25A34 for disorders           About GeneDecksing

Genetic Association Database (GAD): SLC25A34
Human Genome Epidemiology (HuGE) Navigator: SLC25A34 (1 document)

Export disorders for SLC25A34 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for SLC25A34 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC25A34)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
  2. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PubMed id 16949250)1, 2 Haitina T.... Fredriksson R. (2006)
  3. The mitochondrial transporter family SLC25: identifica tion, properties and physiopathology. (PubMed id 23266187)1 Palmieri F. (2013)
  4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
  5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 284723 HGNC: 27653 AceView: LOC284723 Ensembl:ENSG00000162461 euGenes: HUgn284723
ECgene: SLC25A34 H-InvDB: SLC25A34

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for SLC25A34 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for SLC25A34 gene:
Search GeneIP for patents involving SLC25A34

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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