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Aliases for SLC25A34 Gene

Aliases for SLC25A34 Gene

  • Solute Carrier Family 25 Member 34 2 3 5
  • Solute Carrier Family 25, Member 34 2

External Ids for SLC25A34 Gene

Previous GeneCards Identifiers for SLC25A34 Gene

  • GC01P015809
  • GC01P015935
  • GC01P016062
  • GC01P014581

Summaries for SLC25A34 Gene

Entrez Gene Summary for SLC25A34 Gene

  • SLC25A34 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC25A34 Gene

SLC25A34 (Solute Carrier Family 25 Member 34) is a Protein Coding gene. An important paralog of this gene is SLC25A35.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A34 Gene

Genomics for SLC25A34 Gene

Regulatory Elements for SLC25A34 Gene

Enhancers for SLC25A34 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC25A34 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A34 Gene

15,735,088 bp from pter
15,741,396 bp from pter
6,309 bases
Plus strand

Genomic View for SLC25A34 Gene

Genes around SLC25A34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A34 Gene

Proteins for SLC25A34 Gene

  • Protein details for SLC25A34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 25 member 34
    Protein Accession:
    Secondary Accessions:
    • Q68DV0

    Protein attributes for SLC25A34 Gene

    304 amino acids
    Molecular mass:
    32224 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC25A34 Gene

Proteomics data for SLC25A34 Gene at MOPED

Post-translational modifications for SLC25A34 Gene

No Post-translational modifications

Other Protein References for SLC25A34 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A34 Gene

Domains & Families for SLC25A34 Gene

Gene Families for SLC25A34 Gene

Protein Domains for SLC25A34 Gene

Suggested Antigen Peptide Sequences for SLC25A34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



S2534_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A34: view

Function for SLC25A34 Gene

genes like me logo Genes that share phenotypes with SLC25A34: view

Animal Model Products

CRISPR Products

miRNA for SLC25A34 Gene

miRTarBase miRNAs that target SLC25A34

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A34 Gene

Localization for SLC25A34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A34 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC25A34 Gene COMPARTMENTS Subcellular localization image for SLC25A34 gene
Compartment Confidence
mitochondrion 4
plasma membrane 3
extracellular 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SLC25A34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with SLC25A34: view

Pathways & Interactions for SLC25A34 Gene

SuperPathways for SLC25A34 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC25A34 Gene


No data available for Pathways by source and SIGNOR curated interactions for SLC25A34 Gene

Drugs & Compounds for SLC25A34 Gene

No Compound Related Data Available

Transcripts for SLC25A34 Gene

Unigene Clusters for SLC25A34 Gene

Solute carrier family 25, member 34:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A34 Gene

No ASD Table

Relevant External Links for SLC25A34 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC25A34 Gene

mRNA expression in normal human tissues for SLC25A34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A34 Gene

This gene is overexpressed in Muscle - Skeletal (x7.6).

SOURCE GeneReport for Unigene cluster for SLC25A34 Gene Hs.631867

genes like me logo Genes that share expression patterns with SLC25A34: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SLC25A34 Gene

Orthologs for SLC25A34 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A34 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC25A34 35
  • 88.71 (n)
  • 91.12 (a)
SLC25A34 36
  • 91 (a)
(Canis familiaris)
Mammalia SLC25A34 35
  • 88.23 (n)
  • 91.09 (a)
SLC25A34 36
  • 87 (a)
(Mus musculus)
Mammalia Slc25a34 35
  • 86.03 (n)
  • 88.78 (a)
Slc25a34 16
Slc25a34 36
  • 85 (a)
(Pan troglodytes)
Mammalia SLC25A34 35
  • 99.23 (n)
  • 99.01 (a)
SLC25A34 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slc25a34 35
  • 86.27 (n)
  • 89.37 (a)
(Monodelphis domestica)
Mammalia SLC25A34 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia SLC25A34 36
  • 71 (a)
(Anolis carolinensis)
Reptilia SLC25A34 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a34 35
  • 70.12 (n)
  • 73.24 (a)
(Danio rerio)
Actinopterygii slc25a34 35
  • 66.55 (n)
  • 61.86 (a)
CABZ01052268.1 36
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8323 35
  • 54.77 (n)
  • 46.29 (a)
CG18324 36
  • 42 (a)
CG18327 36
  • 42 (a)
CG8323 36
  • 45 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12826g 35
  • 48.12 (n)
  • 42.55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OAC1 35
  • 42.96 (n)
  • 38.99 (a)
OAC1 36
  • 33 (a)
OAC1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU07884 35
  • 51.58 (n)
  • 40 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes oac1 35
  • 44.64 (n)
  • 35.34 (a)
Species with no ortholog for SLC25A34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC25A34 Gene

Gene Tree for SLC25A34 (if available)
Gene Tree for SLC25A34 (if available)

Paralogs for SLC25A34 Gene

Paralogs for SLC25A34 Gene

(8) SIMAP similar genes for SLC25A34 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC25A34: view

Variants for SLC25A34 Gene

Sequence variations from dbSNP and Humsavar for SLC25A34 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1108185 -- 15,737,649(-) AATGA(C/T)CCTCC intron-variant
rs937592 -- 15,737,916(-) AGCAG(A/G)GAGGA intron-variant
rs5772650 -- 15,737,570(+) GCCTC(-/A)AAAAA intron-variant
rs6701500 -- 15,737,203(+) CCTCC(G/T)CCTCG intron-variant
rs7556533 -- 15,737,648(+) TGGAG(A/G/T)ATCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A34 Gene

Variant ID Type Subtype PubMed ID
dgv171n71 CNV Gain 21882294
nsv524044 CNV Loss 19592680
dgv11n27 CNV Gain 19166990
dgv172n71 CNV Gain 21882294
nsv508925 CNV Insertion 20534489
dgv173n71 CNV Loss 21882294
nsv871462 CNV Gain+Loss 21882294
nsv871550 CNV Loss 21882294
nsv870503 CNV Loss 21882294

Variation tolerance for SLC25A34 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.88% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC25A34 Gene

Disorders for SLC25A34 Gene

Relevant External Links for SLC25A34

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC25A34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A34 Gene

Publications for SLC25A34 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F. (Mol. Aspects Med. 2013) 3
  3. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T. … Fredriksson R. (Genomics 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SLC25A34 Gene

Sources for SLC25A34 Gene