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Aliases for SLC25A34 Gene

Aliases for SLC25A34 Gene

  • Solute Carrier Family 25 Member 34 2 3 5
  • Solute Carrier Family 25, Member 34 2

External Ids for SLC25A34 Gene

Previous GeneCards Identifiers for SLC25A34 Gene

  • GC01P015809
  • GC01P015935
  • GC01P016062
  • GC01P014581

Summaries for SLC25A34 Gene

Entrez Gene Summary for SLC25A34 Gene

  • SLC25A34 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC25A34 Gene

SLC25A34 (Solute Carrier Family 25 Member 34) is a Protein Coding gene. An important paralog of this gene is SLC25A35.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A34 Gene

Genomics for SLC25A34 Gene

Regulatory Elements for SLC25A34 Gene

Enhancers for SLC25A34 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F015734 1.1 Ensembl ENCODE 35.9 +1.1 1134 3.0 CTCF KLF1 TFAP4 SAP130 ARID4B BCL11B RAD21 HIC1 ZNF121 ZFHX2 SLC25A34 AGMAT ENSG00000237938
GH01F015740 1.2 Ensembl ENCODE 21.3 +7.1 7091 2.6 HDGF ATF1 PKNOX1 MLX ARID4B DMAP1 ZNF48 ZNF2 YY1 ZNF143 SLC25A34 PLEKHM2 TMEM82 ENSG00000237938
GH01F015629 0.2 ENCODE 21.1 -104.8 -104772 1.1 JUND KLF17 PRDM10 ZNF623 SLC25A34 RSC1A1 PLEKHM2 RNU7-179P ENSG00000237938 ENSG00000251866 FBLIM1 AGMAT DDI2 GC01P015660
GH01F015786 1.1 Ensembl ENCODE 17.2 +53.0 53028 2.7 PKNOX1 MLX ARID4B ZNF48 GTF3C2 GLIS2 FOS SP5 NFYC MIER2 ENSG00000237938 FBLIM1 SLC25A34 C1orf64 SPEN ARHGEF19 RPS16P1 ENSG00000224621 DDI2 RPL12P14
GH01F015747 0.5 Ensembl 16.4 +12.6 12555 0.7 ELF3 INSM2 ZNF2 RARA ZNF335 GLIS2 SCRT2 ZNF391 EGR2 SMAD5 SLC25A34 ENSG00000224459 TMEM82
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SLC25A34 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A34 Gene

Chromosome:
1
Start:
15,735,088 bp from pter
End:
15,741,396 bp from pter
Size:
6,309 bases
Orientation:
Plus strand

Genomic View for SLC25A34 Gene

Genes around SLC25A34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A34 Gene

Proteins for SLC25A34 Gene

  • Protein details for SLC25A34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PIV7-S2534_HUMAN
    Recommended name:
    Solute carrier family 25 member 34
    Protein Accession:
    Q6PIV7
    Secondary Accessions:
    • Q68DV0

    Protein attributes for SLC25A34 Gene

    Size:
    304 amino acids
    Molecular mass:
    32224 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC25A34 Gene

Post-translational modifications for SLC25A34 Gene

No Post-translational modifications

Other Protein References for SLC25A34 Gene

No data available for DME Specific Peptides for SLC25A34 Gene

Domains & Families for SLC25A34 Gene

Gene Families for SLC25A34 Gene

Protein Domains for SLC25A34 Gene

Suggested Antigen Peptide Sequences for SLC25A34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PIV7

UniProtKB/Swiss-Prot:

S2534_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A34: view

Function for SLC25A34 Gene

genes like me logo Genes that share phenotypes with SLC25A34: view

Animal Model Products

miRNA for SLC25A34 Gene

miRTarBase miRNAs that target SLC25A34

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A34 Gene

Localization for SLC25A34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A34 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A34 Gene COMPARTMENTS Subcellular localization image for SLC25A34 gene
Compartment Confidence
mitochondrion 4
plasma membrane 3
extracellular 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SLC25A34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC25A34: view

Pathways & Interactions for SLC25A34 Gene

SuperPathways for SLC25A34 Gene

No Data Available

Interacting Proteins for SLC25A34 Gene

Gene Ontology (GO) - Biological Process for SLC25A34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with SLC25A34: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A34 Gene

Transcripts for SLC25A34 Gene

Unigene Clusters for SLC25A34 Gene

Solute carrier family 25, member 34:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A34 Gene

No ASD Table

Relevant External Links for SLC25A34 Gene

GeneLoc Exon Structure for
SLC25A34
ECgene alternative splicing isoforms for
SLC25A34

Expression for SLC25A34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC25A34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A34 Gene

This gene is overexpressed in Muscle - Skeletal (x7.6).

NURSA nuclear receptor signaling pathways regulating expression of SLC25A34 Gene:

SLC25A34

SOURCE GeneReport for Unigene cluster for SLC25A34 Gene:

Hs.631867
genes like me logo Genes that share expression patterns with SLC25A34: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SLC25A34 Gene

Orthologs for SLC25A34 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A34 34 35
  • 99.23 (n)
cow
(Bos Taurus)
Mammalia SLC25A34 34 35
  • 88.71 (n)
dog
(Canis familiaris)
Mammalia SLC25A34 34 35
  • 88.23 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a34 34
  • 86.27 (n)
mouse
(Mus musculus)
Mammalia Slc25a34 34 16 35
  • 86.03 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC25A34 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A34 35
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC25A34 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a34 34
  • 70.12 (n)
zebrafish
(Danio rerio)
Actinopterygii slc25a34 34
  • 66.55 (n)
CABZ01052268.1 35
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8323 34 35
  • 54.77 (n)
CG18324 35
  • 42 (a)
ManyToMany
CG18327 35
  • 42 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12826g 34
  • 48.12 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OAC1 34 35 37
  • 42.96 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07884 34
  • 51.58 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes oac1 34
  • 44.64 (n)
Species where no ortholog for SLC25A34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC25A34 Gene

ENSEMBL:
Gene Tree for SLC25A34 (if available)
TreeFam:
Gene Tree for SLC25A34 (if available)

Paralogs for SLC25A34 Gene

Paralogs for SLC25A34 Gene

(8) SIMAP similar genes for SLC25A34 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC25A34: view

Variants for SLC25A34 Gene

Sequence variations from dbSNP and Humsavar for SLC25A34 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10927843 -- 15,734,397(+) GGAAG(C/T)GGGAA upstream-variant-2KB, utr-variant-3-prime
rs1108185 -- 15,737,649(-) AATGA(C/T)CCTCC intron-variant
rs111308421 -- 15,739,393(+) CCAGC(A/C)CAAGG downstream-variant-500B, reference, missense, utr-variant-3-prime
rs111349031 -- 15,741,706(+) GCTGT(-/G)GGGGG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs111842948 -- 15,739,361(+) TGGGA(A/C/G/T)GAGCT downstream-variant-500B, reference, synonymous-codon, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC25A34 Gene

Variant ID Type Subtype PubMed ID
dgv11n27 CNV gain 19166990
dgv151n54 CNV gain 21841781
esv3585317 CNV gain 21293372
esv3585319 CNV gain 21293372
nsv508925 CNV insertion 20534489
nsv524044 CNV loss 19592680
nsv545617 CNV loss 21841781
nsv954825 CNV deletion 24416366

Variation tolerance for SLC25A34 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A34 Gene

Disorders for SLC25A34 Gene

Relevant External Links for SLC25A34

Genetic Association Database (GAD)
SLC25A34
Human Genome Epidemiology (HuGE) Navigator
SLC25A34
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A34

No disorders were found for SLC25A34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A34 Gene

Publications for SLC25A34 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T. … Fredriksson R. (Genomics 2006) 3 4 64
  3. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F. (Mol. Aspects Med. 2013) 3 64
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64

Products for SLC25A34 Gene

Sources for SLC25A34 Gene

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