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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC25A33 Gene

protein-coding   GIFtS: 51
GCID: GC01P009523

Solute Carrier Family 25 (Pyrimidine Nucleotide Carrier),...

(Previous names: solute carrier family 25, member 33)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 25 (Pyrimidine Nucleotide Carrier), Member 331 2     Mitochondrial Carrier Protein2
Solute Carrier Family 25, Member 331 2     Novel Mitochondrial Carrier Protein2
Bone Marrow Stromal Cell Mitochondrial Carrier Protein2 3     PNC1 Protein2
BMSC-MCP2 3     Solute Carrier Family 25 Member 332
PNC12     HuBMSC-MCP3
huBMSC-MCP2     Protein PNC13

External Ids:    HGNC: 296811   Entrez Gene: 842752   Ensembl: ENSG000001716127   OMIM: 6108165   UniProtKB: Q9BSK23   

Export aliases for SLC25A33 gene to outside databases

Previous GC identifer: GC01P008749


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC25A33 Gene:
SLC25A33 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 (PubMed
16949250)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SLC25A33 Gene: 
SLC25A33 (solute carrier family 25 (pyrimidine nucleotide carrier), member 33) is a protein-coding gene. Diseases associated with SLC25A33 include prostatitis. An important paralog of this gene is SLC25A36.

UniProtKB/Swiss-Prot: S2533_HUMAN, Q9BSK2
Function: Probable mitochondrial transporter which participates in dendritic cell endocytosis. May associate with
mitochondrial oxidative phosphorylation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_021937.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC25A33 gene promoter:
         HOXA9   HOXA9B   RFX1   Bach2   XBP-1   Meis-1b   HFH-1   FOXO4   Meis-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC25A33 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC25A33

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC25A33


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.22

SLC25A33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A33 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P009523:  view genomic region     (about GC identifiers)

Start:
9,599,528 bp from pter      End:
9,645,237 bp from pter
Size:
45,710 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S2533_HUMAN, Q9BSK2 (See protein sequence)
Recommended Name: Solute carrier family 25 member 33  
Size: 321 amino acids; 35375 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for SLC25A33: NX_Q9BSK2

Explore proteomics data for SLC25A33 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BSK2

  • SLC25A33 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC25A33 Protein Expression
    REFSEQ proteins: NP_115691.1  
    ENSEMBL proteins: 
     ENSP00000306328  

    Human Recombinant Protein Products for SLC25A33: 
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    Novus Biologicals SLC25A33 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLC25A33 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IEA--
    GO:0016021integral to membrane IEA--

    SLC25A33 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: PNC1 
    Miscellaneous SLC25 mitochondrial transporters

    2 InterPro protein domains:
     IPR023395 Mt_carrier_dom
     IPR018108 Mitochondrial_sb/sol_carrier

    Graphical View of Domain Structure for InterPro Entry Q9BSK2

    ProtoNet protein and cluster: Q9BSK2

    UniProtKB/Swiss-Prot: S2533_HUMAN, Q9BSK2
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 3 Solcar repeats


    SLC25A33 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S2533_HUMAN, Q9BSK2
    Function: Probable mitochondrial transporter which participates in dendritic cell endocytosis. May associate with
    mitochondrial oxidative phosphorylation

    Phenotypes:
         2 GenomeRNAi human phenotypes for SLC25A33:

     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC25A33 
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    miRNA
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC25A33

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SLC25A33 (Q9BSK22, 3 ENSP000003063284) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YAE1D1Q9NRH12, 3, ENSP000002232734MINT-8250253 I2D: score=2 STRING: ENSP00000223273
    GLULENSP000003079004STRING: ENSP00000307900
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--

    SLC25A33 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC25A33 (S2533)

    Search CenterWatch for drugs/clinical trials and news about SLC25A33 / S2533

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC25A33 gene: 
    NM_032315.2  

    Unigene Cluster for SLC25A33:

    Solute carrier family 25 (pyrimidine nucleotide carrier), member 33
    Hs.568613  [show with all ESTs]
    Unigene Representative Sequence: BC004991
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000302692(uc001apw.3)
    miRNA
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    Additional mRNA sequence: 

    AF495714.1 AJ880283.1 BC004991.1 BC073135.1 

    10 DOTS entries:

    DT.315462  DT.100814458  DT.92430838  DT.101954849  DT.121429023  DT.92430837  DT.92430842  DT.100814460 
    DT.121429015  DT.95374084 

    24/155 AceView cDNA sequences (see all 155):

    AA352224 BX096810 CA435209 AI671476 BM468629 AA044808 BE466884 BX095617 
    AI470557 CR620898 BC004991 CD368518 CA313909 BM693500 BQ933645 CR595626 
    CA443105 BM759682 NM_032315 AA491285 BM832756 AA968541 CD251663 AW339765 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC25A33 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTATTTAATT
    SLC25A33 Expression
    About this image


    See SLC25A33 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC25A33

    SOURCE GeneReport for Unigene cluster: Hs.568613

    UniProtKB/Swiss-Prot: S2533_HUMAN, Q9BSK2
    Tissue specificity: Expressed in the central nervous system. Also expressed in testis and skeletal muscle. Weakly
    expressed in heart, liver, kidney, prostate, colon and peripheral blood leukocytes

        SABiosciences Custom PCR Arrays for SLC25A33
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A33

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC25A33 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc25a331 , 5 solute carrier family 25, member 331, 5 86.52(n)1
    91.85(a)1
      4 (80.15 cM)5
    705561  NM_027460.21  NP_081736.21 
     1497440365 
    chicken
    (Gallus gallus)
    Aves SLC25A331 solute carrier family 25, member 33 80.34(n)
    90.22(a)
      419442  XM_417600.3  XP_417600.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC25A336
    --
    --
    84(a)
    61(a)
    1 ↔ 1
    possible ortholog
    GL343701.1(242141-251340)
    GL343218.1(203636-216900)
    zebrafish
    (Danio rerio)
    Actinopterygii wufe01d112 Danio rerio cDNA clone MGC65787 IMAGE6790740, complete more 74.64(n)    BC056716.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG183176
    --
    43(a)
    1 → many
    2L(1716244-1724388)
    worm
    (Caenorhabditis elegans)
    Secernentea T09F3.26
    Protein T09F3.2
    36(a)
    1 → many
    II(10391154-10393620)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RIM26
    Mitochondrial pyrimidine nucleotide transporter; i...
    29(a)
    1 → many
    II(607652-608785)


    ENSEMBL Gene Tree for SLC25A33 (if available)
    TreeFam Gene Tree for SLC25A33 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC25A33 gene
    SLC25A362  
    1 SIMAP similar gene for SLC25A33 using alignment to 1 protein entry:     S2533_HUMAN:
    SLC25A36

    SLC25A33 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/899 SNPs in SLC25A33 are shown (see all 899)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1464334771,2
    C--9597706(+) ACTCCA/CTCTCA 1 -- us2k10--------
    rs1411321981,2
    C--9597731(+) AAATT-/AAAAAA 1 -- us2k10--------
    rs1407905321,2
    --9597752(+) AAAAAC/TAAAAA 1 -- us2k10--------
    rs726467131,2
    C,F--9597847(+) AGTCAT/GCCACT 1 -- us2k17Minor allele frequency- G:0.25WA CSA NA EA 365
    rs773664601,2
    F--9597919(+) CTTCTT/GTTTCT 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs120228811,2
    C,F,A,H--9597923(+) TTTTTC/GTCAGA 1 -- us2k1 trp317Minor allele frequency- G:0.32NS EA NA WA CSA 1372
    rs575850811,2
    C,F--9598175(+) TCCGGA/TGCTCT 1 -- us2k12Minor allele frequency- T:0.12WA 120
    rs1894621201,2
    --9598399(+) TAGCTC/TCTTGG 1 -- us2k10--------
    rs764910911,2
    F--9598552(+) AGTCGT/CGTGAC 1 -- us2k11Minor allele frequency- C:0.06WA 118
    rs753033281,2
    C,F--9598564(+) GACTGC/TGCTGC 1 -- us2k11Minor allele frequency- T:0.09WA 118

    HapMap Linkage Disequilibrium report for SLC25A33 (9599528 - 9645237 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SLC25A33:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2658500CNV Deletion23128226
    esv2660900CNV Deletion23128226
    nsv2076CNV Insertion18451855
    nsv871521CNV Loss21882294
    esv2476310CNV Loss19546169

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610816    OMIM disorders: --

    2 diseases for SLC25A33:    About MalaCards
    prostatitis    


    SLC25A33 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC25A33
    Human Genome Epidemiology (HuGE) Navigator: SLC25A33 (1 document)

    Export disorders for SLC25A33 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC25A33 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with SLC25A33)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PubMed id 16949250)1, 2, 3 Haitina T.... Fredriksson R. (2006)
    2. HuBMSC-MCP, a novel member of mitochondrial carrier superfamily, enhances dendritic cell endocytosis. (PubMed id 14715278)1, 2, 3 Wang B....Cao X. (2004)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. The mitochondrial transporter family SLC25: identifica tion, properties and physiopathology. (PubMed id 23266187)1 Palmieri F. (2013)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    7. Mitochondrial pyrimidine nucleotide carrier (PNC1) re gulates mitochondrial biogenesis and the invasive phenotype of cancer cells. (PubMed id 20453889)1 Favre C....O'Connor R. (2010)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae. (PubMed id 12887330)1 Hildyard J.C. and Halestrap A.P. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84275 HGNC: 29681 AceView: MGC4399 Ensembl:ENSG00000171612 euGenes: HUgn84275
    ECgene: SLC25A33 H-InvDB: SLC25A33

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC25A33 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC25A33 gene:
    Search GeneIP for patents involving SLC25A33

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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