SLC25A33 Gene
protein-coding GIFtS: 47
GCID: GC01P009523
|
|
solute carrier family 25 (pyrimidine nucleotide carrier),...(Previous names: solute carrier family 25, member 33 )
| |
Aliases
for SLC25A33 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 25 (Pyrimidine Nucleotide Carrier), Member 331 2 | | Mitochondrial Carrier Protein2 | | BMSC-MCP1 2 3 | | Novel Mitochondrial Carrier Protein2 | | PNC11 2 | | PNC1 Protein2 | | Solute Carrier Family 25, Member 331 2 | | Solute Carrier Family 25 Member 332 | | Bone Marrow Stromal Cell Mitochondrial Carrier Protein2 3 | | HuBMSC-MCP3 | | MGC43991 | | Protein PNC13 | | HuBMSC-MCP3 | | |
Export aliases for SLC25A33 gene to outside databasesPrevious GC identifer: GC01P008749 |
Summaries
for SLC25A33 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLC25A33:
SLC25A33 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 (PubMed16949250)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: S2533_HUMAN, Q9BSK2Function: Probable mitochondrial transporter which participates in dendritic cell endocytosis. May associate withmitochondrial oxidative phosphorylation
|
Genomic Views
for SLC25A33 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_021937.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC25A33 gene promoter:
HOXA9 HOXA9B RFX1 Bach2 XBP-1 Meis-1b HFH-1 FOXO4 Meis-1 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC25A33
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC25A33 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.22 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36.22SLC25A33 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P009523: view genomic region
(about GC identifiers)
Start:
|
9,599,528 bp from pter |
End:
|
9,642,831 bp from pter |
Size:
|
43,304 bases |
Orientation:
|
plus strand |
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Proteins
for SLC25A33 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S2533_HUMAN, Q9BSK2 (See
protein sequence)Recommended Name: Solute carrier family 25 member 33 Size: 321 amino acids; 35375 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane proteinExplore the universe of human proteins at neXtProt for SLC25A33: NX_Q9BSK2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BSK2
SLC25A33 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115691.1
ENSEMBL proteins: ENSP00000306328
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SLC25A33 for ontologies About GeneDecksing
SLC25A33 Antibody Products:
Assay Products for SLC25A33: |
Protein
Domains /
Families
for SLC25A33 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC25A33 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BSK2ProtoNet protein and cluster: Q9BSK2 UniProtKB/Swiss-Prot: S2533_HUMAN, Q9BSK2Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) familySimilarity: Contains 3 Solcar repeats |
Function
for SLC25A33 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: S2533_HUMAN, Q9BSK2Function: Probable mitochondrial transporter which participates in dendritic cell endocytosis. May associate withmitochondrial oxidative phosphorylation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A33 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A33
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A33 |
2 GenomeRNAi human phenotypes for SLC25A33:
|
Pathways & Interactions
for SLC25A33 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC25A33
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for SLC25A33 (Q9BSK22, 3 ENSP000003063284) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006810 | transport |
IEA | -- |
SLC25A33 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC25A33 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC25A33
Search CenterWatch for drugs/clinical trials and news about SLC25A33 / S2533
|
Transcripts
for SLC25A33 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC25A33 gene: NM_032315.2 Unigene Cluster for SLC25A33: Solute carrier family 25 (pyrimidine nucleotide carrier), member 33 Hs.568613 [show with all ESTs]Unigene Representative Sequence: BC0049911 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000302692(uc001apw.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A33 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A33
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLC25A33 (NM_032315) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC25A33 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A33 |
Additional cDNA sequence: AF495714.1 AJ880283.1 BC004991.1 BC073135.1 10 DOTS entries: DT.315462 DT.100814458 DT.92430838 DT.101954849 DT.121429023 DT.92430837 DT.92430842 DT.100814460 DT.121429015 DT.95374084 24/155 AceView cDNA sequences (see all 155): AI129827 CR620898 AI688390 AI470557 BX095617 BC004991 AI678224 CA432133 BM468629 NM_032315 BM759682 CR593565 BF982500 BE466884 BE744082 BX096810 CA443105 CA313909 BC073135 CR594441 BE672341 CD368518 CA435209 BQ012625
GeneLoc Exon Structure
|
Expression
for SLC25A33 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC25A33 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTATTTAATT
About this image
See SLC25A33 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC25A33
SOURCE GeneReport for Unigene cluster: Hs.568613
UniProtKB/Swiss-Prot: S2533_HUMAN, Q9BSK2Tissue specificity: Expressed in the central nervous system. Also expressed in testis and skeletal muscle. Weaklyexpressed in heart, liver, kidney, prostate, colon and peripheral blood leukocytes
SABiosciences Custom PCR Arrays for SLC25A33
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC25A33
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC25A33 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC25A33 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC25A33 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A33 |
Orthologs
for SLC25A33 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC25A33 gene from 7/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SLC25A331 |
solute carrier family 25, member 33 |
80.34(n)
90.22(a) |
|
419442 XM_417600.3 XP_417600.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SLC25A336-- |
-- |
84(a)60(a) |
1 ↔ 1possible ortholog |
GL343701.1(242141-251340) GL343218.1(203278-209232) |
zebrafish
(Danio rerio) |
Actinopterygii |
wufe01d112 |
Danio rerio cDNA clone MGC65787 IMAGE6790740, complete more |
74.64(n) |
|
BC056716.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG183176 |
-- |
42(a) |
1 → many |
2L(1716244-1724388) |
worm
(Caenorhabditis elegans) |
Secernentea |
T09F3.26 |
Carrier protein (C2); Protein T09F3.2 |
35(a) |
1 → many |
II(10391094-10393560) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ATNDT16ATNDT26 |
NAD+ transporter 2 |
30(a)25(a) |
possible orthologpossible ortholog |
2(19487246-19489619) 1(8903470-8906002) |
rice
(Oryza sativa) |
Liliopsida |
---- |
mitochondrial carrier protein, putative, expressed...mitochondrial carrier protein, putative, expressed... |
29(a)29(a) |
possible orthologpossible ortholog |
1(18100505-18110302) 5(16867801-16871840) |
ENSEMBL Gene Tree for SLC25A33 (if available)
TreeFam Gene Tree for SLC25A33 (if available) |
Paralogs
for SLC25A33 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC25A33 gene
- SLC25A362
1 SIMAP similar gene for SLC25A33 using alignment to 1 protein entry: S2533_HUMAN:SLC25A36
SLC25A33 for paralogs About GeneDecksing
|
Genomic Variants
for SLC25A33 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC25A33 (9599528 - 9642831 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC25A33: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC25A33 |
|
Disorders
/ Diseases
for SLC25A33 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC25A33 for disorders About GeneDecksing
OMIM gene information: 610816
OMIM disorders: --
1  disease for SLC25A33: About MalaCardsprostatitis
Human Genome Epidemiology (HuGE) Navigator: SLC25A33 (1 document)
Export disorders for SLC25A33 gene to outside databases
|
Publications
for SLC25A33 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC25A33 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC25A33) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PubMed id 16949250)1, 2, 3 Haitina T.... Fredriksson R. (2006)
- HuBMSC-MCP, a novel member of mitochondrial carrier superfamily, enhances dendritic cell endocytosis. (PubMed id 14715278)1, 2, 3 Wang B....Cao X. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Mitochondrial pyrimidine nucleotide carrier (PNC1) re gulates mitochondrial biogenesis and the invasive phenotype of cancer cells. (PubMed id 20453889)1 Favre C....O'Connor R. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae. (PubMed id 12887330)1 Hildyard J.C. and Halestrap A.P. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SLC25A33 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC25A33 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC25A33 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC25A33 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC25A33 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC25A33 gene:
Search GeneIP for patents involving SLC25A33
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC25A33 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | SLC25A33 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A33 |
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