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Aliases for SLC25A33 Gene

Aliases for SLC25A33 Gene

  • Solute Carrier Family 25 Member 33 2 3
  • Solute Carrier Family 25 (Pyrimidine Nucleotide Carrier), Member 33 2 3 5
  • Bone Marrow Stromal Cell Mitochondrial Carrier Protein 3 4
  • Solute Carrier Family 25, Member 33 2 3
  • HuBMSC-MCP 3 4
  • BMSC-MCP 3 4
  • Novel Mitochondrial Carrier Protein 3
  • Mitochondrial Carrier Protein 3
  • PNC1 Protein 3
  • Protein PNC1 4
  • PNC1 3

External Ids for SLC25A33 Gene

Previous GeneCards Identifiers for SLC25A33 Gene

  • GC01P008749

Summaries for SLC25A33 Gene

Entrez Gene Summary for SLC25A33 Gene

  • SLC25A33 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC25A33 Gene

SLC25A33 (Solute Carrier Family 25 Member 33) is a Protein Coding gene. Diseases associated with SLC25A33 include stromal dystrophy. GO annotations related to this gene include pyrimidine nucleotide transmembrane transporter activity. An important paralog of this gene is SLC25A36.

UniProtKB/Swiss-Prot for SLC25A33 Gene

  • Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria (PubMed:25320081). Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism (PubMed:25320081). Also transports guanine but not adenine (deoxy)nucleotides (PubMed:25320081). Is inhibited strongly by pyridoxal 5-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate) (PubMed:25320081). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (PubMed:20453889). Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production (PubMed:20453889, PubMed:17596519). Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation (PubMed:14715278).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A33 Gene

Genomics for SLC25A33 Gene

Regulatory Elements for SLC25A33 Gene

Promoters for SLC25A33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC25A33 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A33 Gene

Chromosome:
1
Start:
9,539,469 bp from pter
End:
9,585,179 bp from pter
Size:
45,711 bases
Orientation:
Plus strand

Genomic View for SLC25A33 Gene

Genes around SLC25A33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A33 Gene

Proteins for SLC25A33 Gene

  • Protein details for SLC25A33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSK2-S2533_HUMAN
    Recommended name:
    Solute carrier family 25 member 33
    Protein Accession:
    Q9BSK2

    Protein attributes for SLC25A33 Gene

    Size:
    321 amino acids
    Molecular mass:
    35375 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC25A33 Gene

Proteomics data for SLC25A33 Gene at MOPED

Post-translational modifications for SLC25A33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A33 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC25A33 Gene

Domains & Families for SLC25A33 Gene

Gene Families for SLC25A33 Gene

HGNC:
IUPHAR :

Protein Domains for SLC25A33 Gene

Suggested Antigen Peptide Sequences for SLC25A33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BSK2

UniProtKB/Swiss-Prot:

S2533_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A33: view

Function for SLC25A33 Gene

Molecular function for SLC25A33 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.16 mM for UTP (at 25 degrees Celsius) {ECO:0000269 PubMed:25320081}; KM=0.18 mM for CTP (at 25 degrees Celsius) {ECO:0000269 PubMed:25320081}; KM=0.08 mM for TTP (at 25 degrees Celsius) {ECO:0000269 PubMed:25320081}; KM=0.30 mM for GTP (at 25 degrees Celsius) {ECO:0000269 PubMed:25320081}; Vmax=98.5 umol/min/g enzyme toward UTP (at 25 degrees Celsius) {ECO:0000269 PubMed:25320081}; Vmax=22.5 umol/min/g enzyme toward CTP (at 25 degrees Celsius) {ECO:0000269 PubMed:25320081}; Vmax=50.8 umol/min/g enzyme toward TTP (at 25 degrees Celsius) {ECO:0000269 PubMed:25320081}; Vmax=15.7 umol/min/g enzyme toward GTP (at 25 degrees Celsius) {ECO:0000269 PubMed:25320081}; Note=The inhibitory constants (Ki) of these compounds are 174 um (UTP), 195 um (CTP), 318 um (GTP), and 333 um (ITP). UTP is the best substrate. {ECO:0000269 PubMed:25320081};
UniProtKB/Swiss-Prot Function:
Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria (PubMed:25320081). Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism (PubMed:25320081). Also transports guanine but not adenine (deoxy)nucleotides (PubMed:25320081). Is inhibited strongly by pyridoxal 5-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate) (PubMed:25320081). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (PubMed:20453889). Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production (PubMed:20453889, PubMed:17596519). Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation (PubMed:14715278).
UniProtKB/Swiss-Prot Induction:
By INS or IGF1 through the PI-3 kinase/mTOR pathway.
genes like me logo Genes that share phenotypes with SLC25A33: view

Animal Model Products

CRISPR Products

miRNA for SLC25A33 Gene

miRTarBase miRNAs that target SLC25A33

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A33 Gene

Localization for SLC25A33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A33 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A33 Gene COMPARTMENTS Subcellular localization image for SLC25A33 gene
Compartment Confidence
mitochondrion 5
peroxisome 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for SLC25A33 Gene

Pathways & Interactions for SLC25A33 Gene

SuperPathways for SLC25A33 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC25A33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000002 mitochondrial genome maintenance IDA 25320081
GO:0006264 mitochondrial DNA replication IMP 20453889
GO:0006390 transcription from mitochondrial promoter IMP 20453889
GO:0006864 pyrimidine nucleotide transport IDA 25320081
GO:0007005 mitochondrion organization IMP 20453889
genes like me logo Genes that share ontologies with SLC25A33: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A33 Gene

Drugs & Compounds for SLC25A33 Gene

No Compound Related Data Available

Transcripts for SLC25A33 Gene

mRNA/cDNA for SLC25A33 Gene

Unigene Clusters for SLC25A33 Gene

Solute carrier family 25 (pyrimidine nucleotide carrier), member 33:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A33 Gene

No ASD Table

Relevant External Links for SLC25A33 Gene

GeneLoc Exon Structure for
SLC25A33
ECgene alternative splicing isoforms for
SLC25A33

Expression for SLC25A33 Gene

mRNA expression in normal human tissues for SLC25A33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC25A33 Gene

This gene is overexpressed in Bone (45.5) and Cerebrospinal fluid (19.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A33 Gene



SOURCE GeneReport for Unigene cluster for SLC25A33 Gene Hs.568613

mRNA Expression by UniProt/SwissProt for SLC25A33 Gene

Q9BSK2-S2533_HUMAN
Tissue specificity: Expressed in the central nervous system. Also expressed in testis and skeletal muscle. Weakly expressed in heart, liver, kidney, prostate, colon and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with SLC25A33: view

Protein tissue co-expression partners for SLC25A33 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SLC25A33 Gene

Orthologs for SLC25A33 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A33 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC25A33 35
  • 90.55 (n)
  • 95.33 (a)
SLC25A33 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A33 35
  • 93.46 (n)
  • 97.2 (a)
SLC25A33 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a33 35
  • 86.52 (n)
  • 91.85 (a)
Slc25a33 16
Slc25a33 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC25A33 35
  • 99.79 (n)
  • 99.69 (a)
SLC25A33 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a33 35
  • 85.27 (n)
  • 91.54 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC25A33 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A33 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC25A33 35
  • 80.36 (n)
  • 90.6 (a)
SLC25A33 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC25A33 36
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc25a33 35
  • 69.12 (n)
  • 76.92 (a)
wufe01d11 35
slc25a33 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG18317 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T09F3.2 36
  • 37 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM2 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.998 36
  • 42 (a)
OneToMany
Species with no ortholog for SLC25A33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC25A33 Gene

ENSEMBL:
Gene Tree for SLC25A33 (if available)
TreeFam:
Gene Tree for SLC25A33 (if available)

Paralogs for SLC25A33 Gene

Paralogs for SLC25A33 Gene

(1) SIMAP similar genes for SLC25A33 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC25A33: view

Variants for SLC25A33 Gene

Sequence variations from dbSNP and Humsavar for SLC25A33 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs35819756 - 9,580,195(+) CTGCT(A/C)TTTCT reference, missense
rs15349 -- 9,582,642(-) CAAAA(A/G)GAAAT utr-variant-3-prime
rs1137869 -- 9,569,874(+) ATTCT(C/G)ATTTT intron-variant
rs1137870 -- 9,569,877(+) CTCAT(G/T)TTGGC intron-variant
rs1139307 -- 9,564,653(+) aggcc(A/G)aggtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A33 Gene

Variant ID Type Subtype PubMed ID
esv2476310 CNV Loss 19546169
nsv2076 CNV Insertion 18451855
esv2658500 CNV Deletion 23128226
esv2660900 CNV Deletion 23128226
nsv871521 CNV Loss 21882294

Variation tolerance for SLC25A33 Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.86; 48.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A33 Gene

HapMap Linkage Disequilibrium report
SLC25A33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A33 Gene

Disorders for SLC25A33 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC25A33 Gene - From: DISEASES

Disorder Aliases PubMed IDs
stromal dystrophy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC25A33

Genetic Association Database (GAD)
SLC25A33
Human Genome Epidemiology (HuGE) Navigator
SLC25A33
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A33
genes like me logo Genes that share disorders with SLC25A33: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC25A33 Gene

Publications for SLC25A33 Gene

  1. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T. … Fredriksson R. (Genomics 2006) 2 3 4 67
  2. HuBMSC-MCP, a novel member of mitochondrial carrier superfamily, enhances dendritic cell endocytosis. (PMID: 14715278) Wang B. … Cao X. (Biochem. Biophys. Res. Commun. 2004) 2 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. The human SLC25A33 and SLC25A36 genes of solute carrier family 25 encode two mitochondrial pyrimidine nucleotide transporters. (PMID: 25320081) Di Noia M.A. … Palmieri F. (J. Biol. Chem. 2014) 3
  5. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F. (Mol. Aspects Med. 2013) 3

Products for SLC25A33 Gene

Sources for SLC25A33 Gene

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