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Aliases for SLC25A32 Gene

Aliases for SLC25A32 Gene

  • Solute Carrier Family 25 Member 32 2 3 4
  • Solute Carrier Family 25 (Mitochondrial Folate Carrier), Member 32 2 3 5
  • Solute Carrier Family 25, Member 32 2 3
  • MFTC 3 4
  • MFT 3 4
  • Solute Carrier Family 25 (Mitochondrial Folate Carrier) , Member 32 3
  • RREI 3

External Ids for SLC25A32 Gene

Previous GeneCards Identifiers for SLC25A32 Gene

  • GC08M104481
  • GC08M099611
  • GC08M104410

Summaries for SLC25A32 Gene

Entrez Gene Summary for SLC25A32 Gene

  • This gene encodes a member of the P(I/L)W subfamily of mitochondrial carrier family transport proteins. The encoded protein transports folate across the inner mitochondrial membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]

GeneCards Summary for SLC25A32 Gene

SLC25A32 (Solute Carrier Family 25 Member 32) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include folic acid transporter activity. An important paralog of this gene is SLC25A17.

UniProtKB/Swiss-Prot for SLC25A32 Gene

  • Transports folate across the inner membranes of mitochondria.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A32 Gene

Genomics for SLC25A32 Gene

Regulatory Elements for SLC25A32 Gene

Promoters for SLC25A32 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC25A32 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A32 Gene

Chromosome:
8
Start:
103,398,635 bp from pter
End:
103,415,335 bp from pter
Size:
16,701 bases
Orientation:
Minus strand

Genomic View for SLC25A32 Gene

Genes around SLC25A32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A32 Gene

Proteins for SLC25A32 Gene

  • Protein details for SLC25A32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2D1-MFTC_HUMAN
    Recommended name:
    Mitochondrial folate transporter/carrier
    Protein Accession:
    Q9H2D1
    Secondary Accessions:
    • Q96JZ6
    • Q96SU7

    Protein attributes for SLC25A32 Gene

    Size:
    315 amino acids
    Molecular mass:
    35407 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC25A32 Gene

Proteomics data for SLC25A32 Gene at MOPED

Post-translational modifications for SLC25A32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A32 Gene

Antibody Products

No data available for DME Specific Peptides for SLC25A32 Gene

Domains & Families for SLC25A32 Gene

Gene Families for SLC25A32 Gene

HGNC:
IUPHAR :

Protein Domains for SLC25A32 Gene

Suggested Antigen Peptide Sequences for SLC25A32 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H2D1

UniProtKB/Swiss-Prot:

MFTC_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A32: view

Function for SLC25A32 Gene

Molecular function for SLC25A32 Gene

UniProtKB/Swiss-Prot Function:
Transports folate across the inner membranes of mitochondria.
genes like me logo Genes that share phenotypes with SLC25A32: view

Animal Model Products

CRISPR Products

miRNA for SLC25A32 Gene

miRTarBase miRNAs that target SLC25A32

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A32 Gene

Localization for SLC25A32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A32 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A32 Gene COMPARTMENTS Subcellular localization image for SLC25A32 gene
Compartment Confidence
mitochondrion 5
cytosol 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SLC25A32 Gene

Pathways & Interactions for SLC25A32 Gene

genes like me logo Genes that share pathways with SLC25A32: view

Interacting Proteins for SLC25A32 Gene

Gene Ontology (GO) - Biological Process for SLC25A32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IBA --
GO:0006544 glycine metabolic process ISS --
GO:0006810 transport IEA --
GO:0006839 mitochondrial transport IEA --
GO:0046655 folic acid metabolic process TAS --
genes like me logo Genes that share ontologies with SLC25A32: view

No data available for SIGNOR curated interactions for SLC25A32 Gene

Drugs & Compounds for SLC25A32 Gene

(1) Drugs for SLC25A32 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Folic Acid Approved Nutra Transporter, substrate 2924
genes like me logo Genes that share compounds with SLC25A32: view

Transcripts for SLC25A32 Gene

Unigene Clusters for SLC25A32 Gene

Solute carrier family 25 (mitochondrial folate carrier), member 32:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A32 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1:
SP2: -
SP3:
SP4: -

Relevant External Links for SLC25A32 Gene

GeneLoc Exon Structure for
SLC25A32
ECgene alternative splicing isoforms for
SLC25A32

Expression for SLC25A32 Gene

mRNA expression in normal human tissues for SLC25A32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC25A32 Gene

This gene is overexpressed in Breast (51.2) and Lung (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A32 Gene



SOURCE GeneReport for Unigene cluster for SLC25A32 Gene Hs.607819

mRNA Expression by UniProt/SwissProt for SLC25A32 Gene

Q9H2D1-MFTC_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with SLC25A32: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for SLC25A32 Gene

Orthologs for SLC25A32 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A32 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC25A32 35
  • 91.35 (n)
  • 93.91 (a)
SLC25A32 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A32 35
  • 92.64 (n)
  • 94.31 (a)
SLC25A32 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a32 35
  • 88.96 (n)
  • 90.76 (a)
Slc25a32 16
Slc25a32 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC25A32 35
  • 99.79 (n)
  • 100 (a)
SLC25A32 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a32 35
  • 88.22 (n)
  • 90.13 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A32 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC25A32 35
  • 74.92 (n)
  • 76.57 (a)
SLC25A32 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC25A32 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a32 35
  • 68.51 (n)
  • 75.57 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15550 35
zebrafish
(Danio rerio)
Actinopterygii slc25a32b 35
  • 66.01 (n)
  • 70.49 (a)
zgc55610 35
slc25a32a 36
  • 61 (a)
OneToMany
slc25a32b 36
  • 68 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007653 35
  • 55.09 (n)
  • 55.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8026 35
  • 57.4 (n)
  • 58.28 (a)
CG8026 36
  • 54 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea K01C8.7 35
  • 50.83 (n)
  • 43.26 (a)
K01C8.7 36
  • 41 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER366W 35
  • 47.52 (n)
  • 37.45 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F04697g 35
  • 49.45 (n)
  • 38.38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FLX1 35
  • 47.53 (n)
  • 35.38 (a)
YEA6 36
  • 30 (a)
ManyToMany
YIA6 36
  • 27 (a)
ManyToMany
YIA6 38
thale cress
(Arabidopsis thaliana)
eudicotyledons FOLT1 35
  • 51 (n)
  • 46.29 (a)
rice
(Oryza sativa)
Liliopsida Os03g0734700 35
  • 52.7 (n)
  • 45.21 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.124 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04180 35
  • 46.81 (n)
  • 39.35 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC27B12.09c 35
  • 48.74 (n)
  • 40.91 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for SLC25A32:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A32 Gene

ENSEMBL:
Gene Tree for SLC25A32 (if available)
TreeFam:
Gene Tree for SLC25A32 (if available)

Paralogs for SLC25A32 Gene

Paralogs for SLC25A32 Gene

(6) SIMAP similar genes for SLC25A32 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC25A32: view

Variants for SLC25A32 Gene

Sequence variations from dbSNP and Humsavar for SLC25A32 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs17803441 - 103,404,817(+) CTAAA(C/T)GTTCA intron-variant, nc-transcript-variant, reference, missense
rs1061195 -- 103,399,054(-) ATGCC(A/G)GAATA nc-transcript-variant, utr-variant-3-prime
rs1061196 -- 103,398,700(-) CCATT(A/G)TTTAA nc-transcript-variant, utr-variant-3-prime
rs1865853 -- 103,404,465(+) TGGCA(C/T)GTGTC intron-variant
rs1865854 -- 103,404,557(+) GCCAC(C/T)GCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A32 Gene

Variant ID Type Subtype PubMed ID
esv2672690 CNV Deletion 23128226
esv2663185 CNV Deletion 23128226

Variation tolerance for SLC25A32 Gene

Residual Variation Intolerance Score: 42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.00; 60.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A32 Gene

HapMap Linkage Disequilibrium report
SLC25A32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A32 Gene

Disorders for SLC25A32 Gene

Relevant External Links for SLC25A32

Genetic Association Database (GAD)
SLC25A32
Human Genome Epidemiology (HuGE) Navigator
SLC25A32
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A32

No disorders were found for SLC25A32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A32 Gene

Publications for SLC25A32 Gene

  1. Retrovirally mediated complementation of the glyB phenotype. Cloning of a human gene encoding the carrier for entry of folates into mitochondria. (PMID: 10978331) Titus S.A. … Moran R.G. (J. Biol. Chem. 2000) 2 3 4 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. A mutation inactivating the mitochondrial inner membrane folate transporter creates a glycine requirement for survival of chinese hamster cells. (PMID: 15140890) McCarthy E.A. … Moran R.G. (J. Biol. Chem. 2004) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for SLC25A32 Gene

Sources for SLC25A32 Gene

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