SLC25A31 Gene
protein-coding GIFtS: 52
GCID: GC04P128651
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solute carrier family 25 (mitochondrial carrier; adenine...
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Aliases for SLC25A31 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Solute Carrier Family 25 (Mitochondrial Carrier; Adenine NucleotideTranslocator), Member 311 2 | | ANT 42 3 | | ANT41 2 3 5 | | DKFZP434N12351 | | AAC42 3 5 | | SFEC35kDa2 | | Adenine Nucleotide Translocator 42 3 | | Adenine Nucleotide Translocase 42 | | Solute Carrier Family 25 Member 312 3 | | ADP/ATP Translocase 42 | | Sperm Flagellar Energy Carrier Protein2 3 | | SFEC3 | | ADP,ATP Carrier Protein 42 3 | | |
Export aliases for SLC25A31 gene to outside databasesPrevious GC identifers: GC04P129010 GC04P128871 GC04P124379 |
Summaries for SLC25A31 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for SLC25A31: Mitochondrial ADP/ATP carriers, such as SLC25A31, are nuclear-coded mitochondrial proteins that catalyze the exchangeof ATP generated in mitochondria by ATP synthase (see MIM 108729) against ADP produced in cytosol by mostenergy-consuming reactions (Dolce et al., 2005 (PubMed 15670820)).(supplied by OMIM, Mar 2008) UniProtKB/Swiss-Prot: ADT4_HUMAN, Q9H0C2Function: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. Mayserve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotideshuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility Gene Wiki entry for SLC25A31
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Genomic Views for SLC25A31 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SLC25A31 gene promoter: GR LHX3b/Lhx3b GR-beta CUTL1 E4BP4 AREB6 Nkx6-1 HFH-1 LHX3a/Lhx3a GR-alpha Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC25A31
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC25A31 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q28.1 Ensembl cytogenetic band: 4q28.1 HGNC cytogenetic band: 4q28SLC25A31 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P128651: view genomic region
(about GC identifiers)
Start:
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128,651,533 bp from pter |
End:
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128,695,448 bp from pter |
Size:
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43,916 bases |
Orientation:
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plus strand |
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Proteins for SLC25A31 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ADT4_HUMAN, Q9H0C2 (See
protein sequence)Recommended Name: ADP/ATP translocase 4 Size: 315 amino acids; 35022 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein. Cell projection, cilium, flagellum.Note=In sperm flagellum this protein is located in the fibrous sheath, a non-mitochondrial regionExplore the universe of human proteins at neXtProt for SLC25A31: NX_Q9H0C2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H0C2 SLC25A31 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_112581.1 ENSEMBL proteins: ENSP00000281154 Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
SLC25A31 for ontologies About GeneDecksing
SLC25A31 Antibody Products: Assay Products for SLC25A31: |
Protein
Domains / Families for SLC25A31 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC25A31 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H0C2ProtoNet protein and cluster: Q9H0C2 2 Blocks protein families: IPB002067 Mitochondrial carrier protein signature IPB002113 Adenine nucleotide translocator 1 signature
UniProtKB/Swiss-Prot: ADT4_HUMAN, Q9H0C2Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) familySimilarity: Contains 3 Solcar repeats |
Function for SLC25A31 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: ADT4_HUMAN, Q9H0C2Function: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. Mayserve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotideshuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A31 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A31 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SLC25A31 (NM_031291) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC25A31 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A31  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A31 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005215 | transporter activity |
IEA | -- |
SLC25A31 for ontologies About GeneDecksing
Animal Models: 3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Slc25a31):
SLC25A31 for phenotypes About GeneDecksing
|
Pathways & Interactions for SLC25A31 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 2 | Calcium signaling pathway | |
Pathway sources See GeneCards unified pathways Show all pathways
3
Kegg Pathways (Kegg details for SLC25A31):
SLC25A31 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC25A31
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
 5/12 Interacting proteins for SLC25A31 (Q9H0C23 ENSP000002811544) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0055085 | transmembrane transport |
IEA | -- |
SLC25A31 for ontologies About GeneDecksing
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Drugs & Compounds for SLC25A31 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for SLC25A31 Search CenterWatch for drugs/clinical trials and news about SLC25A31 / ADT4 
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Transcripts for SLC25A31 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for SLC25A31 gene: NM_031291.2 Unigene Cluster for SLC25A31: Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 Hs.149030 [show with all ESTs]Unigene Representative Sequence: NM_0312911 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000281154(uc003ifl.3)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A31 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A31 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SLC25A31 (NM_031291) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC25A31 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A31  |
Additional cDNA sequence: AJ863129.1 AL136857.1 AY550240.1 BC022032.2 2 DOTS entries: DT.40208493 DT.121273768 24/31 AceView cDNA sequences (see all 31): BC022032 CD359733 CD244616 AW593852 AL136857 NM_031291 BX101152 BU853653 BI462035 BQ438347 BU567690 AI243338 BG773445 AI148032 BF980134 BU568181 BI520310 BG719446 BU171211 BM563946 BQ429010 AW072406 BI562659 BI562369 GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A31 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | - |   | |   | |   | |   |
ECgene alternative splicing isoforms for SLC25A31
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Expression for SLC25A31 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC25A31 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TCTGGAGTTA
About this image See SLC25A31 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SLC25A31
SOURCE GeneReport for Unigene cluster: Hs.149030 UniProtKB/Swiss-Prot: ADT4_HUMAN, Q9H0C2Tissue specificity: Expressed in brain, liver, sperm and testis SABiosciences Expression via Pathway-Focused PCR Array including SLC25A31:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC25A31 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC25A31 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC25A31 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC25A31 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A31 |
Orthologs for SLC25A31 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC25A31 gene from 4/20 species (see all 20) About this table
ENSEMBL Gene Tree for SLC25A31 (if available) TreeFam Gene Tree for SLC25A31 (if available)  |
Paralogs for SLC25A31 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for SLC25A31 gene
- SLC25A62 SLC25A42 SLC25A52
5 SIMAP similar genes for SLC25A31 using alignment to 1 protein entry: ADT4_HUMAN:SLC25A6 SLC25A4 SLC25A5 SLC25A24 SLC25A16
SLC25A31 for paralogs About GeneDecksing
|
Genomic Variants for SLC25A31 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for SLC25A31 2 CNVs: 1684 6317 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC25A31 |
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Disorders
/ Diseases for SLC25A31 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC25A31 for disorders About GeneDecksing
OMIM gene information: 610796
OMIM disorders: --
3 diseases for SLC25A31: About MalaCardshuntington's disease parkinson's disease malaria Human Genome Epidemiology (HuGE) Navigator: SLC25A31 (1 document) Export disorders for SLC25A31 gene to outside databases
|
Publications for SLC25A31 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC25A31 gene, integrated from 9 sources (see all 19): (articles sorted by number of sources associating them with SLC25A31) | |  | Utopia: connect your pdf to the dynamic world of online information |
- A fourth ADP/ATP carrier isoform in man: identification, bacterial expression, functional characterization and tissue distribution. (PubMed id 15670820)1, 2, 3 Dolce V.... Palmieri F. (2005)
- Compartmentalization of a unique ADP/ATP carrier protein SFEC (sperm flagellar energy carrier, AAC4) with glycolytic enzymes in the fibrous sheath of the human sperm flagellar principal piece. (PubMed id 17137571)1, 2 Kim Y.-H.... Herr J.C. (2007)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Computational analysis of the transcriptional regulat ion of the adenine nucleotide translocator isoform 4 gene and its role in sperm atozoid glycolytic metabolism. (PubMed id 21827840)1 Dupont P.Y. and Stepien G. (2011)
- Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Functional expression of human adenine nucleotide tra nslocase 4 in Saccharomyces cerevisiae. (PubMed id 21532989)1 Hamazaki T....Terada N. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- The fourth isoform of the adenine nucleotide transloc ator inhibits mitochondrial apoptosis in cancer cells. (PubMed id 20060930)1 Gallerne C....Brenner C. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
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External Searches for SLC25A31 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing SLC25A31 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC25A31 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC25A31 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for SLC25A31 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SLC25A31 gene: Search GeneIP for patents involving SLC25A31
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for SLC25A31 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC25A31 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC25A31 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC25A31 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC25A31 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC25A31 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC25A31 |
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 | | SLC25A31 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A31 |
|  |  |  | | | Search ThermoFisher Antibodies for SLC25A31 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A31 |
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