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Aliases for SLC25A31 Gene

Aliases for SLC25A31 Gene

  • Solute Carrier Family 25 Member 31 2 3 4
  • Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 31 2 3
  • Sperm Flagellar Energy Carrier Protein 3 4
  • Adenine Nucleotide Translocator 4 3 4
  • ADP,ATP Carrier Protein 4 3 4
  • ANT 4 3 4
  • AAC4 3 4
  • ANT4 3 4
  • Solute Carrier Family 25 (Mitochondrial Carrier Adenine Nucleotide Translocator), Member 31 5
  • Adenine Nucleotide Translocase 4 3
  • SFEC35kDa 3
  • SFEC 4

External Ids for SLC25A31 Gene

Previous GeneCards Identifiers for SLC25A31 Gene

  • GC04P129010
  • GC04P128871
  • GC04P128651
  • GC04P124379

Summaries for SLC25A31 Gene

Entrez Gene Summary for SLC25A31 Gene

  • The protein encoded by this gene is a member of the ADP/ATP carrier family of proteins that exchange cytosolic ADP for matrix ATP in the mitochondria. Cells over-expressing this gene have been shown to display an anti-apoptotic phenotype. This protein is also thought to play a role in spermatogenesis, where it is believed to associate with a part of the flagellar cytoskeleton and with glycolytic enzymes. Male mice with mutations in the mouse ortholog of this gene are sterile and spermatocytes display an early meiotic arrest phenotype. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

GeneCards Summary for SLC25A31 Gene

SLC25A31 (Solute Carrier Family 25 Member 31) is a Protein Coding gene. Among its related pathways are cGMP-PKG signaling pathway and HTLV-I infection. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLC25A5.

UniProtKB/Swiss-Prot for SLC25A31 Gene

  • Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility.

Gene Wiki entry for SLC25A31 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A31 Gene

Genomics for SLC25A31 Gene

Regulatory Elements for SLC25A31 Gene

Genomic Location for SLC25A31 Gene

Chromosome:
4
Start:
127,730,375 bp from pter
End:
127,774,299 bp from pter
Size:
43,925 bases
Orientation:
Plus strand

Genomic View for SLC25A31 Gene

Genes around SLC25A31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A31 Gene

Proteins for SLC25A31 Gene

  • Protein details for SLC25A31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0C2-ADT4_HUMAN
    Recommended name:
    ADP/ATP translocase 4
    Protein Accession:
    Q9H0C2

    Protein attributes for SLC25A31 Gene

    Size:
    315 amino acids
    Molecular mass:
    35022 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC25A31 Gene

Proteomics data for SLC25A31 Gene at MOPED

Post-translational modifications for SLC25A31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A31 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC25A31 Gene

Domains & Families for SLC25A31 Gene

Gene Families for SLC25A31 Gene

Suggested Antigen Peptide Sequences for SLC25A31 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0C2

UniProtKB/Swiss-Prot:

ADT4_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A31: view

Function for SLC25A31 Gene

Molecular function for SLC25A31 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility.

Phenotypes for SLC25A31 Gene

genes like me logo Genes that share phenotypes with SLC25A31: view

Animal Models for SLC25A31 Gene

MGI Knock Outs for SLC25A31:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A31

CRISPR Products

miRNA for SLC25A31 Gene

miRTarBase miRNAs that target SLC25A31

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC25A31 Gene

Localization for SLC25A31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A31 Gene

Mitochondrion inner membrane; Multi-pass membrane protein. Cell projection, cilium, flagellum. Note=In sperm flagellum this protein is located in the fibrous sheath, a non-mitochondrial region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A31 Gene COMPARTMENTS Subcellular localization image for SLC25A31 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC25A31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
GO:0031514 motile cilium IEA --
genes like me logo Genes that share ontologies with SLC25A31: view

Pathways & Interactions for SLC25A31 Gene

genes like me logo Genes that share pathways with SLC25A31: view

Pathways by source for SLC25A31 Gene

Interacting Proteins for SLC25A31 Gene

Gene Ontology (GO) - Biological Process for SLC25A31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A31: view

No data available for SIGNOR curated interactions for SLC25A31 Gene

Drugs & Compounds for SLC25A31 Gene

(3) Drugs for SLC25A31 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atenolol Approved Pharma Antagonist 99
Hydrochlorothiazide Approved Pharma Inhibition, Inhibitor 387
Metoprolol Approved, Investigational Pharma Antagonist 193
genes like me logo Genes that share compounds with SLC25A31: view

Transcripts for SLC25A31 Gene

mRNA/cDNA for SLC25A31 Gene

Unigene Clusters for SLC25A31 Gene

Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A31 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2: - -

Relevant External Links for SLC25A31 Gene

GeneLoc Exon Structure for
SLC25A31
ECgene alternative splicing isoforms for
SLC25A31

Expression for SLC25A31 Gene

mRNA expression in normal human tissues for SLC25A31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A31 Gene

This gene is overexpressed in Testis (x49.9).

Protein differential expression in normal tissues from HIPED for SLC25A31 Gene

This gene is overexpressed in Brain (38.7), Heart (11.3), and Testis (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A31 Gene



SOURCE GeneReport for Unigene cluster for SLC25A31 Gene Hs.149030

mRNA Expression by UniProt/SwissProt for SLC25A31 Gene

Q9H0C2-ADT4_HUMAN
Tissue specificity: Expressed in brain, liver, sperm and testis.
genes like me logo Genes that share expression patterns with SLC25A31: view

Protein tissue co-expression partners for SLC25A31 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SLC25A31 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A31 36
  • 100 (a)
OneToOne
SLC25A31 35
  • 99.58 (n)
  • 99.68 (a)
cow
(Bos Taurus)
Mammalia SLC25A31 35
  • 91.72 (n)
  • 92.04 (a)
SLC25A31 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A31 36
  • 91 (a)
OneToOne
SLC25A31 35
  • 91.72 (n)
  • 92.04 (a)
mouse
(Mus musculus)
Mammalia Slc25a31 36
  • 88 (a)
OneToOne
Slc25a31 16
Slc25a31 35
  • 85.46 (n)
  • 89.17 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC25A31 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a31 35
  • 83.97 (n)
  • 86.31 (a)
lizard
(Anolis carolinensis)
Reptilia SLC25A31 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ant2 36
  • 67 (a)
ManyToMany
sesB 36
  • 69 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea R07E3.4 36
  • 43 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAC1 36
  • 50 (a)
ManyToMany
AAC3 36
  • 50 (a)
ManyToMany
PET9 36
  • 50 (a)
ManyToMany
PET9 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1260 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G56450 35
  • 55.59 (n)
  • 50.17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
CSA.10315 36
  • 70 (a)
OneToMany
CSA.11146 36
  • 68 (a)
OneToMany
Species with no ortholog for SLC25A31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC25A31 Gene

ENSEMBL:
Gene Tree for SLC25A31 (if available)
TreeFam:
Gene Tree for SLC25A31 (if available)

Paralogs for SLC25A31 Gene

Paralogs for SLC25A31 Gene

(5) SIMAP similar genes for SLC25A31 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC25A31: view

Variants for SLC25A31 Gene

Sequence variations from dbSNP and Humsavar for SLC25A31 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_074177 -
rs769293 -- 127,744,826(-) GGAAG(A/G)AAAAA intron-variant
rs1903104 -- 127,742,708(-) ctaga(A/G)aaaga intron-variant
rs1903105 -- 127,754,321(+) gtgca(A/C/G/T)gcctt intron-variant
rs2279070 -- 127,730,191(-) GGGCC(C/G)AGGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC25A31 Gene

Variant ID Type Subtype PubMed ID
nsv879915 CNV Gain 21882294
nsv879916 CNV Loss 21882294
dgv5711n71 CNV Loss 21882294
nsv830056 CNV Loss 17160897
dgv5712n71 CNV Loss 21882294
nsv879921 CNV Loss 21882294
nsv879923 CNV Loss 21882294
nsv879925 CNV Loss 21882294
nsv830057 CNV Loss 17160897
dgv5713n71 CNV Loss 21882294
nsv290569 CNV Loss 16902084
nsv437935 CNV Loss 16468122

Variation tolerance for SLC25A31 Gene

Residual Variation Intolerance Score: 75.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A31 Gene

HapMap Linkage Disequilibrium report
SLC25A31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A31 Gene

Disorders for SLC25A31 Gene

Relevant External Links for SLC25A31

Genetic Association Database (GAD)
SLC25A31
Human Genome Epidemiology (HuGE) Navigator
SLC25A31
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A31

No disorders were found for SLC25A31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A31 Gene

Publications for SLC25A31 Gene

  1. A fourth ADP/ATP carrier isoform in man: identification, bacterial expression, functional characterization and tissue distribution. (PMID: 15670820) Dolce V. … Palmieri F. (FEBS Lett. 2005) 2 3 4 67
  2. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3
  3. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F. (Mol. Aspects Med. 2013) 3
  4. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  5. Computational analysis of the transcriptional regulation of the adenine nucleotide translocator isoform 4 gene and its role in spermatozoid glycolytic metabolism. (PMID: 21827840) Dupont P.Y. … Stepien G. (Gene 2011) 3

Products for SLC25A31 Gene

Sources for SLC25A31 Gene

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