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Aliases for SLC25A30 Gene

Aliases for SLC25A30 Gene

  • Solute Carrier Family 25 Member 30 2 3 4 5
  • KMCP1 3 4
  • Kidney Mitochondrial Carrier Protein 1 3
  • Solute Carrier Family 25, Member 30 2

External Ids for SLC25A30 Gene

Previous GeneCards Identifiers for SLC25A30 Gene

  • GC13M043766
  • GC13M044865
  • GC13M045967
  • GC13M026765

Summaries for SLC25A30 Gene

Entrez Gene Summary for SLC25A30 Gene

  • Although the outer mitochondrial membrane is permeable to many small metabolites, transport of solutes across the inner mitochondrial membrane is achieved by members of the mitochondrial carrier protein family, such as SLC25A30 (Haguenauer et al., 2005 [PubMed 15809292]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC25A30 Gene

SLC25A30 (Solute Carrier Family 25 Member 30) is a Protein Coding gene. An important paralog of this gene is SLC25A14.

UniProtKB/Swiss-Prot for SLC25A30 Gene

  • Probable transporter.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A30 Gene

Genomics for SLC25A30 Gene

Regulatory Elements for SLC25A30 Gene

Enhancers for SLC25A30 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F045444 0.8 ENCODE 22.6 -29.2 -29215 5.7 ATF1 MLX ZFP64 ARID4B ZNF48 YY1 SLC30A9 SP5 PPARG KAT8 SLC25A30 SLC25A30-AS1 TPT1-AS1 PPIAP25 COG3
GH13F045413 0.2 ENCODE 19.1 +3.6 3637 1.7 PKNOX1 ARNT GLI4 ZBTB40 ZNF2 RARA ZNF391 EGR2 SMARCA5 ZBTB2 SLC25A30 SLC25A30-AS1 RCN1P2
GH13F045398 0.4 ENCODE 17.8 +19.6 19601 1.6 ZNF121 OSR2 ZNF146 GLIS1 TPT1-AS1 SLC25A30 PPIAP25 COG3 RCN1P2 SLC25A30-AS1
GH13F045394 0.7 Ensembl ENCODE 17.7 +22.3 22336 2.7 ETV1 ZIC2 GATA2 MYNN ZNF512 GLIS1 SCRT2 ZNF600 SLC25A30-AS1 SLC25A30 PPIAP25 COG3 TPT1-AS1 RCN1P2
GH13F045372 1 Ensembl ENCODE 17.4 +45.4 45361 1.6 INSM2 FEZF1 ZNF2 ZNF391 ZNF202 ZNF362 ZNF280D OVOL3 ZEB2 TSHZ1 TPT1-AS1 SLC25A30 TPT1 SLC25A30-AS1 GC13P045378 GC13P045379 PIR60049 GC13P045380 ENSG00000228886
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SLC25A30 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A30 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000515582 555 2600 HDGF PKNOX1 ZFP64 ARID4B SIN3A ZNF48 YY1 SLC30A9 GLIS2 SP3

Genomic Location for SLC25A30 Gene

45,393,316 bp from pter
45,418,455 bp from pter
25,140 bases
Minus strand

Genomic View for SLC25A30 Gene

Genes around SLC25A30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A30 Gene

Proteins for SLC25A30 Gene

  • Protein details for SLC25A30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kidney mitochondrial carrier protein 1
    Protein Accession:
    Secondary Accessions:
    • B2RN96
    • B4DZK3
    • F5H8H8

    Protein attributes for SLC25A30 Gene

    291 amino acids
    Molecular mass:
    32475 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A30 Gene


neXtProt entry for SLC25A30 Gene

Post-translational modifications for SLC25A30 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC25A30 Gene

Domains & Families for SLC25A30 Gene

Gene Families for SLC25A30 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A30: view

Function for SLC25A30 Gene

Molecular function for SLC25A30 Gene

UniProtKB/Swiss-Prot Function:
Probable transporter.

Gene Ontology (GO) - Molecular Function for SLC25A30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SLC25A30: view
genes like me logo Genes that share phenotypes with SLC25A30: view

Animal Models for SLC25A30 Gene

MGI Knock Outs for SLC25A30:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A30

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC25A30 Gene

Localization for SLC25A30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A30 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC25A30 Gene COMPARTMENTS Subcellular localization image for SLC25A30 gene
Compartment Confidence
mitochondrion 4
cytosol 2
nucleus 2
peroxisome 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC25A30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS 15809292
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with SLC25A30: view

Pathways & Interactions for SLC25A30 Gene

SuperPathways for SLC25A30 Gene

No Data Available

Interacting Proteins for SLC25A30 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000429168 Q5SVS4-KMCP1_HUMAN for SLC25A30 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLC25A30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006839 mitochondrial transport IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SLC25A30: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A30 Gene

Transcripts for SLC25A30 Gene

Unigene Clusters for SLC25A30 Gene

Solute carrier family 25, member 30:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A30 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - -
SP2: - - -
SP4: - - -

Relevant External Links for SLC25A30 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC25A30 Gene

mRNA expression in normal human tissues for SLC25A30 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A30 Gene

This gene is overexpressed in Heart - Left Ventricle (x6.9).

Protein differential expression in normal tissues from HIPED for SLC25A30 Gene

This gene is overexpressed in Breast (27.5), Bone (26.6), and Neutrophil (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC25A30 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC25A30 Gene:


SOURCE GeneReport for Unigene cluster for SLC25A30 Gene:

genes like me logo Genes that share expression patterns with SLC25A30: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SLC25A30 Gene

Orthologs for SLC25A30 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC25A30 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC25A30 34 35
  • 98.85 (n)
(Monodelphis domestica)
Mammalia SLC25A30 35
  • 94 (a)
(Bos Taurus)
Mammalia SLC25A30 34 35
  • 90.15 (n)
(Canis familiaris)
Mammalia SLC25A30 34 35
  • 90.15 (n)
(Mus musculus)
Mammalia Slc25a30 34 16 35
  • 85.45 (n)
(Rattus norvegicus)
Mammalia Slc25a30 34
  • 85.45 (n)
(Ornithorhynchus anatinus)
Mammalia SLC25A30 35
  • 32 (a)
(Gallus gallus)
Aves SLC25A30 34 35
  • 77.09 (n)
(Anolis carolinensis)
Reptilia SLC25A30 35
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a30 34
  • 77.21 (n)
LOC394840 34
(Danio rerio)
Actinopterygii zgc55596 34
fruit fly
(Drosophila melanogaster)
Insecta Bmcp 34 35
  • 59.57 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011839 34
  • 58.66 (n)
Species where no ortholog for SLC25A30 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC25A30 Gene

Gene Tree for SLC25A30 (if available)
Gene Tree for SLC25A30 (if available)

Paralogs for SLC25A30 Gene

(11) SIMAP similar genes for SLC25A30 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC25A30: view

Variants for SLC25A30 Gene

Sequence variations from dbSNP and Humsavar for SLC25A30 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs10548487 -- 45,414,836(+) TCGTG(-/AA)ACACT intron-variant
rs10551855 -- 45,402,661(+) AGTCT(-/TTCT)AGGAT intron-variant
rs10654013 -- 45,395,613(+) CTGAT(-/GT)TCTCA downstream-variant-500B, utr-variant-3-prime
rs10661035 -- 45,418,578(+) TGAGG(-/AGG)GAGCT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs10687246 -- 45,418,577(+) TGCCT(-/GAG)GAGGG intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC25A30 Gene

Variant ID Type Subtype PubMed ID
dgv223e201 CNV deletion 23290073
esv3631956 CNV loss 21293372
esv3631957 CNV loss 21293372
nsv455875 CNV loss 19166990
nsv510579 CNV deletion 20534489
nsv561578 CNV loss 21841781

Variation tolerance for SLC25A30 Gene

Residual Variation Intolerance Score: 50.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A30 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A30 Gene

Disorders for SLC25A30 Gene

Relevant External Links for SLC25A30

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC25A30 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A30 Gene

Publications for SLC25A30 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. A new renal mitochondrial carrier, KMCP1, is up-regulated during tubular cell regeneration and induction of antioxidant enzymes. (PMID: 15809292) Haguenauer A. … Pecqueur C. (J. Biol. Chem. 2005) 3 22 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64

Products for SLC25A30 Gene

Sources for SLC25A30 Gene

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