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Aliases for SLC25A3 Gene

Aliases for SLC25A3 Gene

  • Solute Carrier Family 25 (Mitochondrial Carrier; Phosphate Carrier), Member 3 2 3
  • PHC 3 4 6
  • Phosphate Transport Protein 3 4
  • PTP 3 4
  • Phosphate Carrier Protein, Mitochondrial 3
  • Solute Carrier Family 25 Member 3 4
  • OK/SW-Cl.48 3

External Ids for SLC25A3 Gene

Previous HGNC Symbols for SLC25A3 Gene

  • PHC

Previous GeneCards Identifiers for SLC25A3 Gene

  • GC12P098290
  • GC12P099491
  • GC12P098920
  • GC12P097489
  • GC12P096048
  • GC12P098997

Summaries for SLC25A3 Gene

Entrez Gene Summary for SLC25A3 Gene

  • The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol. Multiple alternatively spliced transcript variants have been isolated. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC25A3 Gene

SLC25A3 (Solute Carrier Family 25 (Mitochondrial Carrier; Phosphate Carrier), Member 3) is a Protein Coding gene. Diseases associated with SLC25A3 include mitochondrial phosphate carrier deficiency and cardiomyopathy - hypotonia - lactic acidosis. Among its related pathways are C-MYB transcription factor network. GO annotations related to this gene include symporter activity and phosphate ion carrier activity.

UniProtKB/Swiss-Prot for SLC25A3 Gene

  • Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP)

Gene Wiki entry for SLC25A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A3 Gene

Genomics for SLC25A3 Gene

Regulatory Elements for SLC25A3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC25A3 Gene

98,593,591 bp from pter
98,606,379 bp from pter
12,789 bases
Plus strand

Genomic View for SLC25A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC25A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A3 Gene

Proteins for SLC25A3 Gene

  • Protein details for SLC25A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphate carrier protein, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B3KS34
    • Q7Z7N7
    • Q96A03

    Protein attributes for SLC25A3 Gene

    362 amino acids
    Molecular mass:
    40095 Da
    Quaternary structure:
    • Interacts with PPIF; the interaction is impaired by CsA.

    Alternative splice isoforms for SLC25A3 Gene


neXtProt entry for SLC25A3 Gene

Proteomics data for SLC25A3 Gene at MOPED

Post-translational modifications for SLC25A3 Gene

  • Ubiquitination at Lys99, Lys101, Lys112, Lys121, Lys206, Lys209, Lys214, Lys218, Lys247, and Lys252
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC25A3 Gene

Domains for SLC25A3 Gene

Gene Families for SLC25A3 Gene

Protein Domains for SLC25A3 Gene

Suggested Antigen Peptide Sequences for SLC25A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q00325
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A3: view

Function for SLC25A3 Gene

Molecular function for SLC25A3 Gene

UniProtKB/Swiss-Prot Function: Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP)

Gene Ontology (GO) - Molecular Function for SLC25A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015293 symporter activity IEA --
GO:0015320 phosphate ion carrier activity TAS 8144629
GO:0032403 protein complex binding IDA 23209302
genes like me logo Genes that share ontologies with SLC25A3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC25A3 Gene

Localization for SLC25A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A3 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC25A3 Gene COMPARTMENTS Subcellular localization image for SLC25A3 gene
Compartment Confidence
mitochondrion 5
plasma membrane 4
nucleus 3
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC25A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005887 integral component of plasma membrane TAS 8144629
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC25A3: view

Pathways for SLC25A3 Gene

genes like me logo Genes that share pathways with SLC25A3: view

Pathways by source for SLC25A3 Gene

1 BioSystems pathway for SLC25A3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SLC25A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS 8168843
GO:0006810 transport TAS 1777677
GO:0035435 phosphate ion transmembrane transport TAS 8144629
genes like me logo Genes that share ontologies with SLC25A3: view

Compounds for SLC25A3 Gene

(1) HMDB Compounds for SLC25A3 Gene

Compound Synonyms Cas Number PubMed IDs
  • NFB Orthophosphate

(16) Novoseek inferred chemical compound relationships for SLC25A3 Gene

Compound -log(P) Hits PubMed IDs
adp 71 12
atp 65 20
carnitine 46.5 3
alpha-ketoglutarate 34.8 2
citrate 32.1 2
genes like me logo Genes that share compounds with SLC25A3: view

Transcripts for SLC25A3 Gene

Unigene Clusters for SLC25A3 Gene

Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC25A3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - -
SP5: -
SP6: - - - -
SP7: - - - -
SP8: -

Relevant External Links for SLC25A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC25A3 Gene

mRNA expression in normal human tissues for SLC25A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A3 Gene

This gene is overexpressed in Heart - Left Ventricle (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A3 Gene

SOURCE GeneReport for Unigene cluster for SLC25A3 Gene Hs.290404

genes like me logo Genes that share expressions with SLC25A3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLC25A3 Gene

Orthologs for SLC25A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC25A3 35
  • 99.91 (n)
  • 100 (a)
SLC25A3 36
  • 100 (a)
(Bos Taurus)
Mammalia SLC25A3 35
  • 89.01 (n)
  • 91.14 (a)
SLC25A3 36
  • 94 (a)
(Canis familiaris)
Mammalia SLC25A3 35
  • 89.75 (n)
  • 91.97 (a)
SLC25A3 36
  • 93 (a)
(Mus musculus)
Mammalia Slc25a3 35
  • 88.52 (n)
  • 92.72 (a)
Slc25a3 16
Slc25a3 36
  • 89 (a)
(Monodelphis domestica)
Mammalia SLC25A3 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia SLC25A3 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Slc25a3 35
  • 89.14 (n)
  • 93.26 (a)
(Gallus gallus)
Aves SLC25A3 35
  • 80.74 (n)
  • 88.02 (a)
SLC25A3 36
  • 85 (a)
(Anolis carolinensis)
Reptilia SLC25A3 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a3 35
  • 76.75 (n)
  • 86.27 (a)
(Danio rerio)
Actinopterygii slc25a3a 36
  • 73 (a)
slc25a3b 35
  • 72.46 (n)
  • 83.48 (a)
slc25a3b 36
  • 79 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9090 35
  • 62.78 (n)
  • 68.61 (a)
CG9090 36
  • 66 (a)
Mpcp 36
  • 67 (a)
CG9090 37
  • 74 (a)
Mpcp 37
  • 69 (a)
(Caenorhabditis elegans)
Secernentea C14C10.1 36
  • 56 (a)
C33F10.12 36
  • 55 (a)
F01G4.6 35
  • 62.85 (n)
  • 72.29 (a)
F01G4.6 36
  • 60 (a)
T05F1.8 36
  • 55 (a)
C33F10.12 37
  • 66 (a)
C14C10.1 37
  • 60 (a)
T05F1.8 37
  • 63 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PIC2 36
  • 47 (a)
PIC2 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5537 35
(Glycine max)
eudicotyledons Gma.585 35
thale cress
(Arabidopsis thaliana)
eudicotyledons PHT3;2 35
  • 58.28 (n)
  • 56.9 (a)
(Hordeum vulgare)
Liliopsida Hv.9605 35
(Oryza sativa)
Liliopsida Os09g0454600 35
  • 54.1 (n)
  • 52.65 (a)
(Triticum aestivum)
Liliopsida Ta.1412 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 70 (a)
CSA.7863 36
  • 73 (a)
Species with no ortholog for SLC25A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SLC25A3 Gene

Gene Tree for SLC25A3 (if available)
Gene Tree for SLC25A3 (if available)

Paralogs for SLC25A3 Gene

Selected SIMAP similar genes for SLC25A3 Gene using alignment to 7 proteins: Pseudogenes for SLC25A3 Gene

genes like me logo Genes that share paralogs with SLC25A3: view

No data available for Paralogs for SLC25A3 Gene

Variants for SLC25A3 Gene

Sequence variations from dbSNP and Humsavar for SLC25A3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs875899 -- 98,595,029(-) CCCCA(C/G)TTAAG intron-variant
rs1063501 -- 98,595,785(+) GGGGT(A/C)TTAAG synonymous-codon, reference, intron-variant
rs1140504 -- 98,595,731(+) GAGTA(C/T)AGTTG reference, synonymous-codon, intron-variant
rs1140505 -- 98,595,734(+) TACAG(C/T)TGTGA synonymous-codon, reference, intron-variant
rs2012864 -- 98,600,395(+) atgcc(C/G)cgctG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A3 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855

Relevant External Links for SLC25A3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A3 Gene

Disorders for SLC25A3 Gene

(1) OMIM Diseases for SLC25A3 Gene (600370)


  • Mitochondrial phosphate carrier deficiency (MPCD) [MIM:610773]: Fatal disorder of oxidative phosphorylation. Patients have lactic acidosis, hypertrophic cardiomyopathy and muscular hypotonia and die within the first year of life. {ECO:0000269 PubMed:17273968}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for SLC25A3 Gene

(1) Novoseek inferred disease relationships for SLC25A3 Gene

Disease -log(P) Hits PubMed IDs
graves disease 11.1 1

Relevant External Links for SLC25A3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLC25A3: view

Publications for SLC25A3 Gene

  1. The sequences of human and bovine genes of the phosphate carrier from mitochondria contain evidence of alternatively spliced forms. (PMID: 8144629) Dolce V. … Walker J.E. (J. Biol. Chem. 1994) 3 4 23
  2. Chromosomal localization of genes required for the terminal steps of oxidative metabolism: alpha and gamma subunits of ATP synthase and the phosphate carrier. (PMID: 8168843) Jabs E.W. … Pedersen P.L. (Hum. Genet. 1994) 2 3 23
  3. Nucleotide sequence of a human heart cDNA encoding the mitochondrial phosphate carrier. (PMID: 1777677) Dolce V. … Palmieri F. (DNA Seq. 1991) 3 4 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SLC25A3 Gene

Sources for SLC25A3 Gene

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