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Aliases for SLC25A3 Gene

Aliases for SLC25A3 Gene

  • Solute Carrier Family 25 Member 3 2 3 4 5
  • Solute Carrier Family 25 (Mitochondrial Carrier; Phosphate Carrier), Member 3 2 3
  • Phosphate Transport Protein 3 4
  • PTP 3 4
  • PHC 3 4
  • Phosphate Carrier Protein, Mitochondrial 3
  • OK/SW-Cl.48 3

External Ids for SLC25A3 Gene

Previous HGNC Symbols for SLC25A3 Gene

  • PHC

Previous GeneCards Identifiers for SLC25A3 Gene

  • GC12P098290
  • GC12P099491
  • GC12P098920
  • GC12P097489
  • GC12P096048
  • GC12P098997

Summaries for SLC25A3 Gene

Entrez Gene Summary for SLC25A3 Gene

  • The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol. Multiple alternatively spliced transcript variants have been isolated. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC25A3 Gene

SLC25A3 (Solute Carrier Family 25 Member 3) is a Protein Coding gene. Diseases associated with SLC25A3 include Mitochondrial Phosphate Carrier Deficiency. Among its related pathways are C-MYB transcription factor network. GO annotations related to this gene include protein complex binding and phosphate ion carrier activity.

UniProtKB/Swiss-Prot for SLC25A3 Gene

  • Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP).

Gene Wiki entry for SLC25A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A3 Gene

Genomics for SLC25A3 Gene

Regulatory Elements for SLC25A3 Gene

Enhancers for SLC25A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F098643 1.1 ENCODE 18.1 +51.6 51576 4.1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF416 ZNF143 IKBIP TMPO SLC25A3 PPIAP8 APAF1 GC12P098649
GH12F098592 1.1 ENCODE 11.4 +0.9 925 4.3 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TMPO SLC25A3 APAF1 IKBIP GC12M098595
GH12F098635 1 Ensembl ENCODE 11 +42.6 42594 0.9 PKNOX1 JUN INSM2 FEZF1 ZEB1 ZNF366 FOS ZNF600 KLF8 ZNF362 SLC25A3 PPIAP8 SNORA53 IKBIP GC12M098601
GH12F098618 0.5 Ensembl 18.3 +25.7 25710 1.4 ZNF121 CEBPB EP300 MYC SLC25A3 APAF1 IKBIP PPIAP8 GC12M098601
GH12F098605 0.9 Ensembl ENCODE 7.4 +13.6 13583 2.5 CTCF ZNF654 MAX CEBPB RAD21 IKZF1 CEBPA SMC3 BCL6 MAFK IKBIP APAF1 SLC25A3 GC12M098601 GC12M098602
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A3 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090372 909 3401 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for SLC25A3 Gene

Chromosome:
12
Start:
98,593,591 bp from pter
End:
98,606,379 bp from pter
Size:
12,789 bases
Orientation:
Plus strand

Genomic View for SLC25A3 Gene

Genes around SLC25A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A3 Gene

Proteins for SLC25A3 Gene

  • Protein details for SLC25A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00325-MPCP_HUMAN
    Recommended name:
    Phosphate carrier protein, mitochondrial
    Protein Accession:
    Q00325
    Secondary Accessions:
    • B3KS34
    • Q7Z7N7
    • Q96A03

    Protein attributes for SLC25A3 Gene

    Size:
    362 amino acids
    Molecular mass:
    40095 Da
    Quaternary structure:
    • Interacts with PPIF; the interaction is impaired by CsA.

    Alternative splice isoforms for SLC25A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A3 Gene

Post-translational modifications for SLC25A3 Gene

  • Ubiquitination at Lys 99, Lys 101, Lys 121, Lys 206, Lys 214, Lys 218, Lys 247, and Lys 252
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC25A3 Gene

Domains & Families for SLC25A3 Gene

Gene Families for SLC25A3 Gene

Protein Domains for SLC25A3 Gene

Suggested Antigen Peptide Sequences for SLC25A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q00325

UniProtKB/Swiss-Prot:

MPCP_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A3: view

Function for SLC25A3 Gene

Molecular function for SLC25A3 Gene

UniProtKB/Swiss-Prot Function:
Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP).

Gene Ontology (GO) - Molecular Function for SLC25A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015293 symporter activity IEA --
GO:0015320 phosphate ion carrier activity TAS 8144629
GO:0032403 protein complex binding IDA 23209302
genes like me logo Genes that share ontologies with SLC25A3: view
genes like me logo Genes that share phenotypes with SLC25A3: view

Human Phenotype Ontology for SLC25A3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SLC25A3 Gene

MGI Knock Outs for SLC25A3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SLC25A3 Gene

Localization for SLC25A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A3 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 5
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC25A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005739 mitochondrion IDA,TAS --
GO:0005743 mitochondrial inner membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS 8144629
genes like me logo Genes that share ontologies with SLC25A3: view

Pathways & Interactions for SLC25A3 Gene

genes like me logo Genes that share pathways with SLC25A3: view

Pathways by source for SLC25A3 Gene

1 BioSystems pathway for SLC25A3 Gene

Gene Ontology (GO) - Biological Process for SLC25A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS 8168843
GO:0006810 transport TAS 1777677
GO:0035435 phosphate ion transmembrane transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A3: view

No data available for SIGNOR curated interactions for SLC25A3 Gene

Drugs & Compounds for SLC25A3 Gene

(11) Drugs for SLC25A3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for SLC25A3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with SLC25A3: view

Transcripts for SLC25A3 Gene

Unigene Clusters for SLC25A3 Gene

Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - -
SP5: -
SP6: - - - -
SP7: - - - -
SP8: -
SP9:

Relevant External Links for SLC25A3 Gene

GeneLoc Exon Structure for
SLC25A3
ECgene alternative splicing isoforms for
SLC25A3

Expression for SLC25A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC25A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A3 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.6).

Protein differential expression in normal tissues from HIPED for SLC25A3 Gene

This gene is overexpressed in Nasal epithelium (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC25A3 Gene



Protein tissue co-expression partners for SLC25A3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC25A3 Gene:

SLC25A3

SOURCE GeneReport for Unigene cluster for SLC25A3 Gene:

Hs.290404
genes like me logo Genes that share expression patterns with SLC25A3: view

No data available for mRNA Expression by UniProt/SwissProt for SLC25A3 Gene

Orthologs for SLC25A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A3 34 35
  • 99.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A3 35
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC25A3 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A3 34 35
  • 89.75 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a3 34
  • 89.14 (n)
cow
(Bos Taurus)
Mammalia SLC25A3 34 35
  • 89.01 (n)
mouse
(Mus musculus)
Mammalia Slc25a3 34 16 35
  • 88.52 (n)
chicken
(Gallus gallus)
Aves SLC25A3 34 35
  • 80.74 (n)
lizard
(Anolis carolinensis)
Reptilia SLC25A3 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a3 34
  • 76.75 (n)
zebrafish
(Danio rerio)
Actinopterygii slc25a3a 35
  • 73 (a)
OneToMany
slc25a3b 34 35
  • 72.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mpcp 36 35
  • 69 (a)
CG9090 36 34 35
  • 62.78 (n)
worm
(Caenorhabditis elegans)
Secernentea C33F10.12 36 35
  • 66 (a)
T05F1.8 36 35
  • 63 (a)
F01G4.6 34 35
  • 62.85 (n)
C14C10.1 36 35
  • 60 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PIC2 35 37
  • 47 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons PHT3;2 34
  • 58.28 (n)
soybean
(Glycine max)
eudicotyledons Gma.585 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5537 34
rice
(Oryza sativa)
Liliopsida Os09g0454600 34
  • 54.1 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.9605 34
wheat
(Triticum aestivum)
Liliopsida Ta.1412 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7863 35
  • 73 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
Species where no ortholog for SLC25A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SLC25A3 Gene

ENSEMBL:
Gene Tree for SLC25A3 (if available)
TreeFam:
Gene Tree for SLC25A3 (if available)

Paralogs for SLC25A3 Gene

(1) SIMAP similar genes for SLC25A3 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for SLC25A3 Gene

genes like me logo Genes that share paralogs with SLC25A3: view

No data available for Paralogs for SLC25A3 Gene

Variants for SLC25A3 Gene

Sequence variations from dbSNP and Humsavar for SLC25A3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs104894375 Mitochondrial phosphate carrier deficiency (MPCD) [MIM:610773], Pathogenic 98,595,490(+) TGGAG(A/G)AATTA intron-variant, reference, missense
rs745305932 Pathogenic 98,595,424(+) TTCCA(A/G)TCAAA intron-variant
rs202241756 Likely benign 98,599,972(+) GGTTG(C/T)TCCTC downstream-variant-500B, reference, missense
rs750003586 Likely benign 98,595,554(+) AGAAT(G/T)CAGGT intron-variant, reference, missense
rs863224206 Likely benign 98,594,047(+) GTGCA(A/C)GATGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SLC25A3 Gene

Variant ID Type Subtype PubMed ID
nsv559918 CNV loss 21841781
nsv7234 OTHER inversion 18451855

Variation tolerance for SLC25A3 Gene

Residual Variation Intolerance Score: 15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A3 Gene

Human Gene Mutation Database (HGMD)
SLC25A3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A3 Gene

Disorders for SLC25A3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC25A3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, and GeneCards

Disorder Aliases PubMed IDs
mitochondrial phosphate carrier deficiency
  • mpcd
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

MPCP_HUMAN
  • Mitochondrial phosphate carrier deficiency (MPCD) [MIM:610773]: Fatal disorder of oxidative phosphorylation. Patients have lactic acidosis, hypertrophic cardiomyopathy and muscular hypotonia and die within the first year of life. {ECO:0000269 PubMed:17273968}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SLC25A3

Genetic Association Database (GAD)
SLC25A3
Human Genome Epidemiology (HuGE) Navigator
SLC25A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A3
genes like me logo Genes that share disorders with SLC25A3: view

No data available for Genatlas for SLC25A3 Gene

Publications for SLC25A3 Gene

  1. Chromosomal localization of genes required for the terminal steps of oxidative metabolism: alpha and gamma subunits of ATP synthase and the phosphate carrier. (PMID: 8168843) Jabs E.W. … Pedersen P.L. (Hum. Genet. 1994) 2 3 22 64
  2. The sequences of human and bovine genes of the phosphate carrier from mitochondria contain evidence of alternatively spliced forms. (PMID: 8144629) Dolce V. … Walker J.E. (J. Biol. Chem. 1994) 3 4 22 64
  3. Nucleotide sequence of a human heart cDNA encoding the mitochondrial phosphate carrier. (PMID: 1777677) Dolce V. … Palmieri F. (DNA Seq. 1991) 3 4 22 64
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  5. Mitochondrial phosphate-carrier deficiency: a novel disorder of oxidative phosphorylation. (PMID: 17273968) Mayr J.A. … Sperl W. (Am. J. Hum. Genet. 2007) 3 4 64

Products for SLC25A3 Gene

Sources for SLC25A3 Gene

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