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Aliases for SLC25A29 Gene

Aliases for SLC25A29 Gene

  • Solute Carrier Family 25 (Mitochondrial Carnitine/Acylcarnitine Carrier), Member 29 2 3
  • ORNT3 3 4 6
  • Mitochondrial Carnitine/Acylcarnitine Carrier Protein CACL 3 4
  • Carnitine/Acylcarnitine Translocase-Like 3 4
  • Mitochondrial Ornithine Transporter 3 3 4
  • Solute Carrier Family 25, Member 29 2 3
  • C14orf69 3 4
  • CACL 3 6
  • Mitochondrial Basic Amino Acids Transporter 3
  • Carnitine-Acylcarnitine Translocase Like 3
  • Chromosome 14 Open Reading Frame 69 2
  • Solute Carrier Family 25 Member 29 4
  • CACT-Like 4

External Ids for SLC25A29 Gene

Previous HGNC Symbols for SLC25A29 Gene

  • C14orf69

Previous GeneCards Identifiers for SLC25A29 Gene

  • GC14M098749
  • GC14M098750
  • GC14M099827
  • GC14M100759
  • GC14M080938

Summaries for SLC25A29 Gene

Entrez Gene Summary for SLC25A29 Gene

  • This gene encodes a nuclear-encoded mitochondrial protein that is a member of the large family of solute carrier family 25 (SLC25) mitochondrial transporters. The members of this superfamily are involved in numerous metabolic pathways and cell functions. This gene product was previously reported to be a mitochondrial carnitine-acylcarnitine-like (CACL) translocase (PMID:128829710) or an ornithine transporter (designated ORNT3, PMID:19287344), however, a recent study characterized the main role of this protein as a mitochondrial transporter of basic amino acids, with a preference for arginine and lysine (PMID:24652292). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]

GeneCards Summary for SLC25A29 Gene

SLC25A29 (Solute Carrier Family 25 (Mitochondrial Carnitine/Acylcarnitine Carrier), Member 29) is a Protein Coding gene. GO annotations related to this gene include acyl carnitine transmembrane transporter activity. An important paralog of this gene is SLC25A20.

UniProtKB/Swiss-Prot for SLC25A29 Gene

  • Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Does not transport carnitine nor acylcarnitines. Functions by both counter-exchange and uniport mechanisms.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A29 Gene

Genomics for SLC25A29 Gene

Regulatory Elements for SLC25A29 Gene

Genomic Location for SLC25A29 Gene

Start:
100,279,177 bp from pter
End:
100,306,547 bp from pter
Size:
27,371 bases
Orientation:
Minus strand

Genomic View for SLC25A29 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC25A29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A29 Gene

Proteins for SLC25A29 Gene

  • Protein details for SLC25A29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8R3-MCATL_HUMAN
    Recommended name:
    Mitochondrial basic amino acids transporter
    Protein Accession:
    Q8N8R3
    Secondary Accessions:
    • A3KMR5
    • Q541V0

    Protein attributes for SLC25A29 Gene

    Size:
    303 amino acids
    Molecular mass:
    32062 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD62317.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC25A29 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A29 Gene

Proteomics data for SLC25A29 Gene at MOPED

Post-translational modifications for SLC25A29 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SLC25A29 Gene

Domains for SLC25A29 Gene

Gene Families for SLC25A29 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC25A29 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N8R3

UniProtKB/Swiss-Prot:

MCATL_HUMAN :
  • Q8N8R3
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A29: view

Function for SLC25A29 Gene

Molecular function for SLC25A29 Gene

UniProtKB/Swiss-Prot Function: Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Does not transport carnitine nor acylcarnitines. Functions by both counter-exchange and uniport mechanisms.

Gene Ontology (GO) - Molecular Function for SLC25A29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015227 acyl carnitine transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC25A29: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC25A29 Gene

Localization for SLC25A29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A29 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A29 Gene COMPARTMENTS Subcellular localization image for SLC25A29 gene
Compartment Confidence
mitochondrion 5
extracellular 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC25A29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC25A29: view

Pathways for SLC25A29 Gene

SuperPathways for SLC25A29 Gene

No Data Available

Interacting Proteins for SLC25A29 Gene

Gene Ontology (GO) - Biological Process for SLC25A29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006844 acyl carnitine transport --
GO:1902616 acyl carnitine transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A29: view

No data available for Pathways by source for SLC25A29 Gene

Compounds for SLC25A29 Gene

(1) HMDB Compounds for SLC25A29 Gene

Compound Synonyms Cas Number PubMed IDs
L-Carnitine
  • (-)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate
541-15-1

(1) Drugbank Compounds for SLC25A29 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Carnitine
  • (-)-Carnitine
541-15-1 target
genes like me logo Genes that share compounds with SLC25A29: view

Transcripts for SLC25A29 Gene

Unigene Clusters for SLC25A29 Gene

Solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A29 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e · 11f
SP1: - - - - - - - - - -
SP2:
SP3: - - - - - - - - - - -
SP4: - -
SP5: -
SP6: - - - - -
SP7: - - - - - - - - - - - -
SP8: - - - - - -
SP9:
SP10: -
SP11:

Relevant External Links for SLC25A29 Gene

GeneLoc Exon Structure for
SLC25A29
ECgene alternative splicing isoforms for
SLC25A29

Expression for SLC25A29 Gene

mRNA expression in normal human tissues for SLC25A29 Gene

mRNA differential expression in normal tissues according to GTEx for SLC25A29 Gene

This gene is overexpressed in Thyroid (10.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A29 Gene

SOURCE GeneReport for Unigene cluster for SLC25A29 Gene Hs.578109

genes like me logo Genes that share expressions with SLC25A29: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SLC25A29 Gene

Orthologs for SLC25A29 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A29 35
  • 99.23 (n)
  • 99.34 (a)
SLC25A29 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC25A29 35
  • 90.38 (n)
  • 92.62 (a)
SLC25A29 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A29 35
  • 89.67 (n)
  • 89.3 (a)
SLC25A29 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a29 35
  • 83.8 (n)
  • 90.56 (a)
Slc25a29 16
Slc25a29 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC25A29 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A29 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a29 35
  • 84.27 (n)
  • 90.56 (a)
chicken
(Gallus gallus)
Aves SLC25A29 35
  • 70.12 (n)
  • 78.21 (a)
SLC25A29 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC25A29 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16277 35
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a29 35
  • 68.08 (n)
  • 78.45 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7448 35
zebrafish
(Danio rerio)
Actinopterygii slc25a29 35
  • 71.6 (n)
  • 75 (a)
slc25a29 36
  • 71 (a)
OneToMany
SLC25A29 (2 of 2) 36
  • 70 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009128 35
  • 59.7 (n)
  • 54.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4995 35
  • 54.84 (n)
  • 50.57 (a)
CG4995 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C54G10.4 35
  • 51.21 (n)
  • 50.19 (a)
C54G10.4 36
  • 36 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YMC1 36
  • 32 (a)
ManyToMany
YMC1 38
YMC2 36
  • 30 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17864g 35
  • 45.42 (n)
  • 38.17 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons BAC2 35
  • 47.51 (n)
  • 39.18 (a)
rice
(Oryza sativa)
Liliopsida Os01g0225000 35
  • 55.35 (n)
  • 43.66 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for SLC25A29:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A29 Gene

ENSEMBL:
Gene Tree for SLC25A29 (if available)
TreeFam:
Gene Tree for SLC25A29 (if available)

Paralogs for SLC25A29 Gene

Paralogs for SLC25A29 Gene

genes like me logo Genes that share paralogs with SLC25A29: view

Variants for SLC25A29 Gene

Sequence variations from dbSNP and Humsavar for SLC25A29 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs9201 -- 100,291,314(-) GCATT(C/T)TCAGT utr-variant-3-prime, intron-variant
rs9291 -- 100,282,507(-) AAACA(G/T)AATTT intron-variant
rs10830 -- 100,282,587(-) CACTT(A/C)AGAAA intron-variant
rs11427 -- 100,282,657(-) TACTA(A/C/T)ATTTC intron-variant
rs14260 -- 100,291,347(+) GAGCA(A/G)AGGGA utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A29 Gene

Variant ID Type Subtype PubMed ID
nsv902226 CNV Loss 21882294
nsv832875 CNV Loss 17160897
dgv1979n71 CNV Loss 21882294
nsv902229 CNV Loss 21882294
nsv902230 CNV Loss 21882294

Relevant External Links for SLC25A29 Gene

HapMap Linkage Disequilibrium report
SLC25A29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A29 Gene

Disorders for SLC25A29 Gene

(1) University of Copenhagen DISEASES for SLC25A29 Gene

Relevant External Links for SLC25A29

Genetic Association Database (GAD)
SLC25A29
Human Genome Epidemiology (HuGE) Navigator
SLC25A29
genes like me logo Genes that share disorders with SLC25A29: view

No data available for UniProtKB/Swiss-Prot for SLC25A29 Gene

Publications for SLC25A29 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The human and mouse SLC25A29 mitochondrial transporters rescue the deficient ornithine metabolism in fibroblasts of patients with the hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome. (PMID: 19287344) Camacho J.A. … Rioseco-Camacho N. (Pediatr. Res. 2009) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. The human gene SLC25A29, of solute carrier family 25, encodes a mitochondrial transporter of basic amino acids. (PMID: 24652292) Porcelli V. … Palmieri F. (J. Biol. Chem. 2014) 3 4
  5. A novel mitochondrial carnitine-acylcarnitine translocase induced by partial hepatectomy and fasting. (PMID: 12882971) Sekoguchi E. … Matsuura A. (J. Biol. Chem. 2003) 3 25

Products for SLC25A29 Gene

  • antibodies-online peptides for SLC25A29
  • antibodies-online antibodies for SLC25A29
  • antibodies-online kits for SLC25A29

Sources for SLC25A29 Gene

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